miRTarBase - #MIRT041084


—
pre-miRNA Information
pre-miRNA hsa-mir-504   
Genomic Coordinates chrX: 138667711 - 138667793
Synonyms MIRN504, hsa-mir-504, MIR504
Description Homo sapiens miR-504 stem-loop
Comment The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies .
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-504-5p
Sequence 13| AGACCCUGGUCUGCACUCUAUC |34
Evidence Experimental
Experiments Array-cloned
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1297440872 6 dbSNP
rs1429220261 12 dbSNP
rs745623382 14 dbSNP
rs770027520 14 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol TMEM8A   
Synonyms M83, PGAP6, TMEM6, TMEM8
Description transmembrane protein 8A
Transcript NM_021259   
Expression
Putative miRNA Targets on TMEM8A
3'UTR of TMEM8A
(miRNA target sites are highlighted)		 
>TMEM8A|NM_021259|3'UTR
   1 CACTGGCCTGGGGACAGCTGCTGCTCTGATGACCTCTTCAGCCAGGAGCTGTATCGAGGGGGAGGCGCCTGGTCCAGCCC
  81 TGGACAGATTGATTTCCAGCTGAATAAATTGGCCTAGATACCCTCTTACTTCCTCCTACTGAGGAGAGGGCCACCCCTCC
 161 CTCACACGCACCTCTCCTCGCCAGCTGCCTGCTCGCTGCTGAGATCCCTCTGCAGATCCCAGCTGCTGTCTGCAGTGGCC
 241 CCTGGGGCCTGGGCTTGGTTACTTGGAGACCACAGGTGCCTGTGCGAGGGTGGGGCTGTGTGCTCTGCTGGCCTGTGGGT
 321 GGCTAGAGATGGGGAGAAGGACTCCCTATGGTCCTGTTCCCTGGCGAGGCTGTGGTGAGACCCATGGCGCCCAGGAGCCC
 401 TGAGCCCACCACTGGGGCCGGGAGCTGTGGACTCCGAGACCCCTGCTCCTGGCCCCTGTGTGGCCCTGATGCCAGCCTGC
 481 CTGGGGCATGGAGGATCCCCCTCTGCTGCTGTGGTCACCATAGGGACGGGAGACGGAGGTTTCCCCCAGAGCTGATGGGC
 561 ACTGGGGATGCAGGCTCCCGCCCCGCCCCTCCCTTTTTCCTGGCTCTGGAGCCTTGGGTCCCTGAGAAGAGCTTCCTTGG
 641 ACTGGGGTGCTCTGCTGCTCTGGGGGTTTGGCCCAGAAGGAACCCCTACCCAGCCCTGTCCACCCACCCCAGCGTTCCTG
 721 GGCCCCCCTCTGGGAGCTTCCTCTTGGTCCCAGGAGCTGCGGTGGTGTCTGCCCCCTGCACTGGGCTCTGTGCCCTGTGG
 801 GTGTTCAGGAGACTGGACTGTCTCTGCTCCTCATGCAAACCTTGTGGGGGAAGCAATGACCAGGAGCAGCACCTGGCCCC
 881 TCCCTGAGGCCTGTGAGTGTCTCGGATCCGCCCTGGAGAAGTGAGTGGCTGAGACCCGGGTGGGGCCCTCCTACCCTTGG
 961 CTCTGGGGGCTTCCCTTCTGGGTCTTGTCCGGGATATGGCCTTCCTGAAGGTCTTACCTCCCCCAGCCGCCCTGCACTTG
1041 ACCACCAAAGCAATCTCTAAGCTTATAAAGGAGAAACATATATATATGGGGTTTTTTGGAGTAAAGGAAAATTCTAAGAT
1121 ATTAAGACATATTTTTATGTAGATCTGATCTATCTGTGTTTGGTGAATTTAATATTCTACATTGATTTTTCAAACTAAAC
1201 GAGTTTTTACA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' cuAUC--UCACGUCUG-GUCCCAGa 5'
            |:|  | || :||: |||| || 
Target 5' gaTGGGCACTGGGGATGCAGGCTCc 3'
 554 - 578 122.00 -14.40
2 
miRNA  3' cuauCUCA-CG--UCUGGUCCCAga 5'
              |||| ||  ||||| ||||  
Target 5' aagtGAGTGGCTGAGACCCGGGTgg 3'
 919 - 943 120.00 -17.30
3 
miRNA  3' cuAUCUC--ACGUCUGGUCCCAGa 5'
            |:|:|  | |   :| ||||| 
Target 5' tcTGGGGGCTTCCCTTCTGGGTCt 3'
 962 - 985 114.00 -15.80
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN24305393 7 COSMIC
COSN31606236 11 COSMIC
COSN31508000 17 COSMIC
COSN13671955 36 COSMIC
COSN30163610 39 COSMIC
COSN30664071 51 COSMIC
COSN13671954 55 COSMIC
COSN30182327 60 COSMIC
COSN30189840 61 COSMIC
COSN30452265 61 COSMIC
COSN30161371 72 COSMIC
COSN26999150 85 COSMIC
COSN31586517 157 COSMIC
COSN17990824 542 COSMIC
COSN17599967 1017 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1474045761 3 dbSNP
rs1256364450 5 dbSNP
rs367970385 7 dbSNP
rs1205680102 8 dbSNP
rs772828593 10 dbSNP
rs939247480 12 dbSNP
rs771779402 15 dbSNP
rs560141603 23 dbSNP
rs1359919160 28 dbSNP
rs761333258 33 dbSNP
rs201563770 36 dbSNP
rs1294031504 42 dbSNP
rs980427699 46 dbSNP
rs1353870507 49 dbSNP
rs1039318228 55 dbSNP
rs1427872568 56 dbSNP
rs1190707992 58 dbSNP
rs548574173 61 dbSNP
rs920304894 62 dbSNP
rs1449636185 63 dbSNP
rs910758213 66 dbSNP
rs372169854 67 dbSNP
rs1467167501 72 dbSNP
rs17136392 75 dbSNP
rs924761377 80 dbSNP
rs1381032126 97 dbSNP
rs1015492618 100 dbSNP
rs374992245 119 dbSNP
rs1233842216 121 dbSNP
rs968767237 122 dbSNP
rs1350118166 123 dbSNP
rs766860310 128 dbSNP
rs1260250263 133 dbSNP
rs954955611 135 dbSNP
rs1203328177 137 dbSNP
rs189245166 138 dbSNP
rs1367946233 140 dbSNP
rs1028984143 146 dbSNP
rs756205733 150 dbSNP
rs1192580104 154 dbSNP
rs1392929439 155 dbSNP
rs184459981 157 dbSNP
rs1176076804 164 dbSNP
rs991864372 167 dbSNP
rs958651650 168 dbSNP
rs1036055758 169 dbSNP
rs1440694981 174 dbSNP
rs1324326387 177 dbSNP
rs1295689360 179 dbSNP
rs904618448 180 dbSNP
rs141601991 194 dbSNP
rs565150847 195 dbSNP
rs1226491152 196 dbSNP
rs1269979824 197 dbSNP
rs886968588 206 dbSNP
rs1025412088 210 dbSNP
rs1250938628 213 dbSNP
rs1010723827 215 dbSNP
rs892324263 223 dbSNP
rs1429411750 227 dbSNP
rs1416833816 230 dbSNP
rs1161976826 239 dbSNP
rs1052696866 241 dbSNP
rs995233940 249 dbSNP
rs1163143255 251 dbSNP
rs1003497797 256 dbSNP
rs1192596316 262 dbSNP
rs413390 264 dbSNP
rs1371231797 265 dbSNP
rs1293815058 268 dbSNP
rs1039349397 276 dbSNP
rs1289086612 279 dbSNP
rs1329727532 282 dbSNP
rs1044757709 283 dbSNP
rs575300594 285 dbSNP
rs181421378 286 dbSNP
rs1287457554 292 dbSNP
rs1263237343 301 dbSNP
rs1323357388 302 dbSNP
rs1221811067 311 dbSNP
rs1232003839 321 dbSNP
rs920350484 324 dbSNP
rs1228975100 329 dbSNP
rs1183663246 332 dbSNP
rs1307655538 344 dbSNP
rs1475133318 345 dbSNP
rs541796621 353 dbSNP
rs942401604 354 dbSNP
rs1416405398 355 dbSNP
rs1406357177 356 dbSNP
rs1169977698 358 dbSNP
rs1352925423 362 dbSNP
rs762153431 365 dbSNP
rs940414723 366 dbSNP
rs908074392 375 dbSNP
rs890790735 383 dbSNP
rs988036805 384 dbSNP
rs1398494725 388 dbSNP
rs1347829154 389 dbSNP
rs1381047278 390 dbSNP
rs1052476769 392 dbSNP
rs954966666 407 dbSNP
rs1404944635 412 dbSNP
rs1206866950 415 dbSNP
rs1274711887 415 dbSNP
rs922147594 419 dbSNP
rs933571076 420 dbSNP
rs974729470 420 dbSNP
rs1473422618 423 dbSNP
rs968719410 435 dbSNP
rs574530092 436 dbSNP
rs1022027337 440 dbSNP
rs1462576056 445 dbSNP
rs1372670682 449 dbSNP
rs1417816196 452 dbSNP
rs1451548927 455 dbSNP
rs1168840746 458 dbSNP
rs538753489 459 dbSNP
rs956313228 462 dbSNP
rs116311065 463 dbSNP
rs1003341911 497 dbSNP
rs762144988 498 dbSNP
rs1336271903 499 dbSNP
rs1360786042 500 dbSNP
rs1265196071 521 dbSNP
rs906469285 525 dbSNP
rs1044971813 527 dbSNP
rs867891052 528 dbSNP
rs866127767 530 dbSNP
rs1297932019 532 dbSNP
rs534934117 534 dbSNP
rs1198176584 539 dbSNP
rs1037769900 541 dbSNP
rs1443427360 543 dbSNP
rs1216470028 545 dbSNP
rs1215717322 546 dbSNP
rs570635602 553 dbSNP
rs1466563922 554 dbSNP
rs951274472 560 dbSNP
rs1394656700 566 dbSNP
rs558722741 571 dbSNP
rs1025443247 572 dbSNP
rs774760131 573 dbSNP
rs1223290874 574 dbSNP
rs995263521 575 dbSNP
rs1329797590 577 dbSNP
rs1414956578 579 dbSNP
rs962518789 580 dbSNP
rs1437069746 582 dbSNP
rs1018476358 584 dbSNP
rs907582079 585 dbSNP
rs1215816728 587 dbSNP
rs537109655 589 dbSNP
rs1364625581 590 dbSNP
rs1345198646 594 dbSNP
rs1223688885 595 dbSNP
rs1051882870 599 dbSNP
rs116122370 600 dbSNP
rs1329544608 603 dbSNP
rs188630065 606 dbSNP
rs1209708364 611 dbSNP
rs530016242 613 dbSNP
rs1201358282 631 dbSNP
rs1430249622 642 dbSNP
rs367857324 645 dbSNP
rs1409600289 646 dbSNP
rs998190203 652 dbSNP
rs1159536172 663 dbSNP
rs968940370 664 dbSNP
rs749759683 671 dbSNP
rs903402436 673 dbSNP
rs1477585304 680 dbSNP
rs1440776746 682 dbSNP
rs144618420 686 dbSNP
rs989186857 688 dbSNP
rs947575225 690 dbSNP
rs532687878 694 dbSNP
rs1419133996 703 dbSNP
rs914734473 711 dbSNP
rs1196366960 713 dbSNP
rs1056311497 714 dbSNP
rs1180049891 719 dbSNP
rs937422533 722 dbSNP
rs1473497193 723 dbSNP
rs928643897 725 dbSNP
rs956154374 726 dbSNP
rs1164808894 727 dbSNP
rs1390959674 729 dbSNP
rs534907266 730 dbSNP
rs1480287632 732 dbSNP
rs1003388015 734 dbSNP
rs1410970317 741 dbSNP
rs1293254401 746 dbSNP
rs970575751 747 dbSNP
rs1200189494 753 dbSNP
rs770496007 754 dbSNP
rs1285188894 759 dbSNP
rs1343353756 761 dbSNP
rs973955129 767 dbSNP
rs556462496 769 dbSNP
rs962548782 772 dbSNP
rs1018089961 776 dbSNP
rs565288276 780 dbSNP
rs1281750558 784 dbSNP
rs1255328142 786 dbSNP
rs1422021996 788 dbSNP
rs1023453829 795 dbSNP
rs550355862 806 dbSNP
rs1335239361 807 dbSNP
rs531847475 810 dbSNP
rs1429889147 816 dbSNP
rs955123150 822 dbSNP
rs1400640175 824 dbSNP
rs1307091835 827 dbSNP
rs745327130 828 dbSNP
rs563392157 829 dbSNP
rs1326267959 830 dbSNP
rs1029750500 840 dbSNP
rs999153359 846 dbSNP
rs1012209010 848 dbSNP
rs1336352803 850 dbSNP
rs746511566 867 dbSNP
rs1254344878 872 dbSNP
rs1413666901 874 dbSNP
rs541585579 875 dbSNP
rs1015937789 877 dbSNP
rs1464307542 880 dbSNP
rs574453079 882 dbSNP
rs1422961391 886 dbSNP
rs1391578736 887 dbSNP
rs1449731372 898 dbSNP
rs893317078 899 dbSNP
rs1176175523 900 dbSNP
rs1445949625 903 dbSNP
rs1055942984 904 dbSNP
rs937433056 909 dbSNP
rs1340003383 935 dbSNP
rs7199715 937 dbSNP
rs886208385 938 dbSNP
rs1256570380 939 dbSNP
rs1328418074 940 dbSNP
rs1206543884 952 dbSNP
rs114939241 954 dbSNP
rs577221971 955 dbSNP
rs933052701 963 dbSNP
rs900719847 967 dbSNP
rs973986180 969 dbSNP
rs941258819 971 dbSNP
rs1411826419 974 dbSNP
rs1456120310 981 dbSNP
rs1248208158 987 dbSNP
rs567587066 989 dbSNP
rs776010121 990 dbSNP
rs955303702 991 dbSNP
rs1387374056 1000 dbSNP
rs1287842031 1002 dbSNP
rs1349723603 1004 dbSNP
rs1226510888 1016 dbSNP
rs184694899 1017 dbSNP
rs576187595 1023 dbSNP
rs1319969066 1024 dbSNP
rs966394462 1026 dbSNP
rs555033153 1029 dbSNP
rs1011851464 1031 dbSNP
rs1250447019 1032 dbSNP
rs536361082 1036 dbSNP
rs893358543 1043 dbSNP
rs928605333 1056 dbSNP
rs192354739 1061 dbSNP
rs777441492 1062 dbSNP
rs1351792311 1069 dbSNP
rs114270655 1073 dbSNP
rs1307434635 1075 dbSNP
rs1023506067 1078 dbSNP
rs540 1080 dbSNP
rs1471566586 1086 dbSNP
rs1290178504 1087 dbSNP
rs1373757697 1088 dbSNP
rs568009670 1088 dbSNP
rs1323092022 1091 dbSNP
rs569969615 1093 dbSNP
rs1481812138 1098 dbSNP
rs145132969 1101 dbSNP
rs1472774699 1105 dbSNP
rs551424172 1107 dbSNP
rs1416423829 1112 dbSNP
rs55938006 1114 dbSNP
rs1424596248 1118 dbSNP
rs1360237660 1125 dbSNP
rs1289333592 1127 dbSNP
rs1308735452 1128 dbSNP
rs756580431 1129 dbSNP
rs886129088 1131 dbSNP
rs1341671887 1132 dbSNP
rs1029950957 1133 dbSNP
rs1271017827 1133 dbSNP
rs1246224358 1137 dbSNP
rs550251392 1139 dbSNP
rs997256415 1143 dbSNP
rs941291427 1149 dbSNP
rs900227615 1150 dbSNP
rs1339639858 1152 dbSNP
rs1039182230 1156 dbSNP
rs1229924271 1156 dbSNP
rs143931556 1157 dbSNP
rs1208708125 1162 dbSNP
rs1366118403 1163 dbSNP
rs947521160 1167 dbSNP
rs933873360 1169 dbSNP
rs1462074427 1176 dbSNP
rs1163391552 1182 dbSNP
rs1188141828 1185 dbSNP
rs1388497759 1196 dbSNP
rs1490506104 1200 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions Flp-In T-REx 293-hAGO1 cells
Location of target site 3'UTR
Original Description (Extracted from the article) ... Validation of interactions identified by CLASH suppports their reliability. ...

- Helwak A; Kudla G; Dudnakova T; Tollervey D, 2013, Cell.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' cuaucucacGUCUGGUCCCAga 5'
                   ::|||::||||  
Target 5' -----tcctTGGACTGGGGTgc 3'
 		1 - 17
2 
miRNA  3' cuaUCUCACGUCUGGUCccaga 5'
             :|:|| ::| ||||     
Target 5' ctgGGGGTTTGGCCCAG----- 3'
 		27 - 43
Article - Helwak A; Kudla G; Dudnakova T; Tollervey D
- Cell, 2013
MicroRNAs (miRNAs) play key roles in gene regulation, but reliable bioinformatic or experimental identification of their targets remains difficult. To provide an unbiased view of human miRNA targets, we developed a technique for ligation and sequencing of miRNA-target RNA duplexes associated with human AGO1. Here, we report data sets of more than 18,000 high-confidence miRNA-mRNA interactions. The binding of most miRNAs includes the 5' seed region, but around 60% of seed interactions are noncanonical, containing bulged or mismatched nucleotides. Moreover, seed interactions are generally accompanied by specific, nonseed base pairing. 18% of miRNA-mRNA interactions involve the miRNA 3' end, with little evidence for 5' contacts, and some of these were functionally validated. Analyses of miRNA:mRNA base pairing showed that miRNA species systematically differ in their target RNA interactions, and strongly overrepresented motifs were found in the interaction sites of several miRNAs. We speculate that these affect the response of RISC to miRNA-target binding.
LinkOut: [PMID: 23622248]
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
STAD 0.516 0 0.406 0.02 24 Click to see details
HNSC -0.271 0.08 -0.263 0.09 28 Click to see details
COAD -0.706 0.09 -0.500 0.2 5 Click to see details
KICH 0.268 0.1 0.403 0.02 25 Click to see details
PRAD 0.144 0.16 0.104 0.24 50 Click to see details
THCA -0.143 0.16 -0.089 0.27 49 Click to see details
BRCA 0.123 0.16 0.170 0.09 65 Click to see details
BLCA -0.28 0.17 -0.174 0.28 14 Click to see details
CHOL 0.387 0.2 0.393 0.19 7 Click to see details
ESCA 0.434 0.23 0.600 0.14 5 Click to see details
KIRP 0.125 0.26 0.145 0.23 28 Click to see details
LUSC -0.107 0.29 0.012 0.48 29 Click to see details
KIRC -0.078 0.29 -0.086 0.27 51 Click to see details
LIHC -0.082 0.3 -0.081 0.3 43 Click to see details
LUAD 0.128 0.35 -0.036 0.46 11 Click to see details
UCEC -0.069 0.4 -0.082 0.39 15 Click to see details
UCEC -0.069 0.4 -0.082 0.39 15 Click to see details
PAAD -1 0.5 -1.000 0.5 4 Click to see details
PAAD -1 0.5 -1.000 0.5 4 Click to see details
PAAD -1 0.5 -1.000 0.5 4 Click to see details
PAAD -1 0.5 -1.000 0.5 4 Click to see details
101 hsa-miR-504-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT000044 DRD1 dopamine receptor D1 2 1
MIRT004457 VEGFA vascular endothelial growth factor A 2 1
MIRT016249 BAX BCL2 associated X, apoptosis regulator 1 1
MIRT016251 GADD45A growth arrest and DNA damage inducible alpha 1 1
MIRT016252 FAS Fas cell surface death receptor 1 1
MIRT016253 BBC3 BCL2 binding component 3 1 1
MIRT016254 TP53I3 tumor protein p53 inducible protein 3 1 1
MIRT016255 TCEAL1 transcription elongation factor A like 1 2 1
MIRT016256 MDM2 MDM2 proto-oncogene 2 1
MIRT016257 TP53 tumor protein p53 3 1
MIRT041072 P2RY13 purinergic receptor P2Y13 1 1
MIRT041073 PPIL1 peptidylprolyl isomerase like 1 1 1
MIRT041074 ZNF814 zinc finger protein 814 1 1
MIRT041075 HIST1H2AC histone cluster 1 H2A family member c 1 1
MIRT041076 FEM1A fem-1 homolog A 1 1
MIRT041077 TXNRD1 thioredoxin reductase 1 1 1
MIRT041078 RAI1 retinoic acid induced 1 1 1
MIRT041079 SRRM2 serine/arginine repetitive matrix 2 1 1
MIRT041080 HNRNPAB heterogeneous nuclear ribonucleoprotein A/B 1 1
MIRT041081 PDLIM1 PDZ and LIM domain 1 1 1
MIRT041082 FAM208B family with sequence similarity 208 member B 1 1
MIRT041083 PSAT1 phosphoserine aminotransferase 1 1 1
MIRT041084 TMEM8A transmembrane protein 8A 1 1
MIRT041085 RABGAP1 RAB GTPase activating protein 1 1 1
MIRT041086 BRD2 bromodomain containing 2 1 1
MIRT041087 C11orf58 chromosome 11 open reading frame 58 1 1
MIRT041088 CNOT8 CCR4-NOT transcription complex subunit 8 1 1
MIRT041089 RPL10 ribosomal protein L10 1 1
MIRT041090 SMCR7L mitochondrial elongation factor 1 1 1
MIRT041091 CENPBD1 CENPB DNA-binding domain containing 1 1 1
MIRT041092 SF3B1 splicing factor 3b subunit 1 1 1
MIRT041093 MTFP1 mitochondrial fission process 1 1 1
MIRT438313 CDK6 cyclin dependent kinase 6 1 1
MIRT438352 TFF1 trefoil factor 1 3 1
MIRT443009 KBTBD12 kelch repeat and BTB domain containing 12 2 2
MIRT448052 SFRP1 secreted frizzled related protein 1 2 2
MIRT457649 ZNF69 zinc finger protein 69 2 2
MIRT458626 TRIM72 tripartite motif containing 72 2 2
MIRT466176 TMED5 transmembrane p24 trafficking protein 5 2 2
MIRT472583 NACC1 nucleus accumbens associated 1 2 2
MIRT473576 MAT2A methionine adenosyltransferase 2A 2 6
MIRT485155 RASL10B RAS like family 10 member B 2 2
MIRT490063 PRRT2 proline rich transmembrane protein 2 2 2
MIRT493015 NANOS1 nanos C2HC-type zinc finger 1 2 2
MIRT499425 PLCG2 phospholipase C gamma 2 2 11
MIRT506956 HOXB3 homeobox B3 2 4
MIRT507100 GPCPD1 glycerophosphocholine phosphodiesterase 1 2 2
MIRT508101 ANKRD33B ankyrin repeat domain 33B 2 4
MIRT522215 NR2C2 nuclear receptor subfamily 2 group C member 2 2 6
MIRT530327 TNFRSF10D TNF receptor superfamily member 10d 2 2
MIRT531042 ZNF502 zinc finger protein 502 2 2
MIRT532580 GSS glutathione synthetase 2 2
MIRT534841 RAB15 RAB15, member RAS oncogene family 2 2
MIRT536820 HMGN2 high mobility group nucleosomal binding domain 2 2 2
MIRT538303 CSNK2A1 casein kinase 2 alpha 1 2 2
MIRT546344 TFAP2C transcription factor AP-2 gamma 2 2
MIRT546704 RORA RAR related orphan receptor A 2 4
MIRT549222 BCL2L11 BCL2 like 11 2 4
MIRT549623 TMEM101 transmembrane protein 101 2 2
MIRT549931 NDUFB5 NADH:ubiquinone oxidoreductase subunit B5 2 2
MIRT550163 ZNF223 zinc finger protein 223 2 4
MIRT550555 ARSK arylsulfatase family member K 2 2
MIRT553402 TRIM2 tripartite motif containing 2 2 4
MIRT554084 SNX4 sorting nexin 4 2 4
MIRT556962 IER3IP1 immediate early response 3 interacting protein 1 2 2
MIRT558525 CSRNP3 cysteine and serine rich nuclear protein 3 2 2
MIRT558565 CRLF3 cytokine receptor like factor 3 2 4
MIRT560946 TPM4 tropomyosin 4 2 4
MIRT561628 SERBP1 SERPINE1 mRNA binding protein 1 2 2
MIRT562174 HOXA13 homeobox A13 2 2
MIRT568635 ACVR2A activin A receptor type 2A 2 2
MIRT574908 Plcg2 phospholipase C, gamma 2 2 7
MIRT575177 Atg9a autophagy related 9A 2 2
MIRT611972 PKD1 polycystin 1, transient receptor potential channel interacting 2 2
MIRT613623 CLASP1 cytoplasmic linker associated protein 1 2 4
MIRT635830 OPA3 OPA3, outer mitochondrial membrane lipid metabolism regulator 2 4
MIRT637344 DARS2 aspartyl-tRNA synthetase 2, mitochondrial 2 4
MIRT643205 JAK3 Janus kinase 3 2 2
MIRT650232 SIGLEC9 sialic acid binding Ig like lectin 9 2 2
MIRT655940 NDUFA4P1 NDUFA4, mitochondrial complex associated pseudogene 1 2 2
MIRT662021 ZNF445 zinc finger protein 445 2 2
MIRT662037 FUT2 fucosyltransferase 2 2 2
MIRT666873 POU2F2 POU class 2 homeobox 2 2 2
MIRT684310 TRUB2 TruB pseudouridine synthase family member 2 2 2
MIRT687333 OSMR oncostatin M receptor 2 2
MIRT689008 ATP6AP1 ATPase H+ transporting accessory protein 1 2 2
MIRT695137 PRY2 PTPN13-like, Y-linked 2 2 2
MIRT695154 PRY PTPN13-like, Y-linked 2 2
MIRT700695 POLR3D RNA polymerase III subunit D 2 2
MIRT703269 GNL3L G protein nucleolar 3 like 2 2
MIRT708941 CRY2 cryptochrome circadian clock 2 2 2
MIRT709200 SAPCD2 suppressor APC domain containing 2 2 2
MIRT709572 PDE4A phosphodiesterase 4A 2 2
MIRT711295 PSME3 proteasome activator subunit 3 2 2
MIRT712425 MACROD2 MACRO domain containing 2 2 2
MIRT713941 PIGR polymeric immunoglobulin receptor 2 2
MIRT714124 TMED9 transmembrane p24 trafficking protein 9 2 2
MIRT714630 KIAA1143 KIAA1143 2 2
MIRT724046 SMIM14 small integral membrane protein 14 2 2
MIRT724649 PKDREJ polycystin family receptor for egg jelly 2 2
MIRT725476 GRAP2 GRB2-related adaptor protein 2 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-504 Emodin NULL 3220 Microarray K562 cells 23744534 2013 down-regualted
miR-504 Mistletoe lectin-I NULL NULL Microarray colorectal cancer cells CLY cells 20955366 2011 down-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-504 Ceritinib 57379345 NSC776422 approved sensitive High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-mir-504 Androstenedione+Anastrozole resistant cell line (MCF-7)
hsa-mir-504 Ceritinib 57379345 NSC776422 approved sensitive cell line (H3122)
hsa-miR-504-5p Oxaliplatin 6857599 NSC266046 approved resistant High Colorectal Cancer cell line (HT-29)
hsa-miR-504-5p Oxaliplatin 6857599 NSC266046 approved sensitive High Colorectal Cancer cell line (RKO)
hsa-miR-504-5p Plx-4720 24180719 NSC757438 sensitive High Thyroid Cancer cell line (8505c, BCPAP)
hsa-miR-504-5p Vemurafenib 42611257 NSC761431 approved sensitive High Melanoma cell line (A375, IGR37, 501Mel)
hsa-miR-504-5p Dabrafenib 44462760 NSC764134 approved sensitive High Melanoma cell line (A375, IGR37, 501Mel)
hsa-miR-504-5p Dabrafenib 44462760 NSC764134 approved resistant High Melanoma cell line (A375, IGR37, 501Mel)
hsa-miR-504-5p Vemurafenib 42611257 NSC761431 approved resistant High Melanoma cell line (A375, IGR37, 501Mel)
hsa-miR-504-5p Ceritinib 57379345 NSC776422 approved sensitive High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-miR-504-5p Fulvestrant 17756771 NSC719276 approved sensitive High Breast Cancer cell line (MCF-7, MCF-7-TT)
hsa-miR-504-5p Gefitinib 123631 NSC715055 approved resistant cell line (PC9)
hsa-miR-504-5p Osimertinib 71496458 NSC779217 approved resistant cell line (PC9)
hsa-miR-504-5p Vemurafenib 42611257 NSC761431 approved resistant cell line (A375)
hsa-miR-504-5p Vemurafenib 42611257 NSC761431 approved sensitive cell line (451Lu)
hsa-miR-504-5p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-504-5p Vemurafenib 42611257 NSC761431 approved resistant cell line (LM47)
hsa-miR-504-5p Vemurafenib 42611257 NSC761431 approved sensitive cell line (LM16)
hsa-miR-504-5p Vemurafenib 42611257 NSC761431 approved resistant cell line (LM17)
hsa-miR-504-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (CIS)
hsa-miR-504-5p Cisplatin 5460033 NSC119875 approved resistant cell line (MGC-803)
hsa-miR-504-5p Ethanol+Tamoxifen sensitive cell line (LY2)
hsa-miR-504-5p Sunitinib 5329102 NSC750690 approved resistant tissue (CardA)
hsa-miR-504-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-504-5p Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (1500 ng/ml)
hsa-miR-504-5p Ceritinib 57379345 NSC776422 approved sensitive cell line (H3122)
hsa-miR-504-5p Cisplatin 5460033 NSC119875 approved resistant cell line (H460)

Error report submission