miRTarBase - #MIRT041085


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pre-miRNA Information
pre-miRNA hsa-mir-504   
Genomic Coordinates chrX: 138667711 - 138667793
Synonyms MIRN504, hsa-mir-504, MIR504
Description Homo sapiens miR-504 stem-loop
Comment The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies .
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-504-5p
Sequence 13| AGACCCUGGUCUGCACUCUAUC |34
Evidence Experimental
Experiments Array-cloned
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1297440872 6 dbSNP
rs1429220261 12 dbSNP
rs745623382 14 dbSNP
rs770027520 14 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol RABGAP1   
Synonyms GAPCENA, TBC1D11
Description RAB GTPase activating protein 1
Transcript NM_012197   
Expression
Putative miRNA Targets on RABGAP1
3'UTR of RABGAP1
(miRNA target sites are highlighted)		 
>RABGAP1|NM_012197|3'UTR
   1 GAGCAGCTGCCGCCTCCCGACACCTTCAGAAAACACGACACCTTTTGTTGCCTTCTTTGGCCAGATGTGTGATTCTGTGA
  81 CTTGTCCCAGGACCAGAATGTACCTAAGTCAGATCCATAGACGCATGTTGGTAGGTCACTGGACCAGAGCTTGTGAAGCA
 161 GGCAACCTCTGGGGTAAGACTACTGATACTAACAGGCCTGCTAGCTCAGCCGACGCTCTGGACACTCTAGAAATCACTCC
 241 TCAGTGTGACCTCCCAGGCCTCTTCCCCGTGTACGTCAACACCTCACCCAGCCTAAAGGCTGAGTTTACATGATCAGAGT
 321 TAGGGGATCCTTCAGTCTGTTGATTTTTTTTCTAAACCTTTTTTTTTTAATATACATATATATATATATATATATATATA
 401 TATATATATATATATATATATATAGTGGGGGTGGGGCAAGGGATCAGAAATTCAAATAATTCTTTTCTGCTTCAATGCCA
 481 GCAGAAGGTCCCCCAGGTAGACATGGAGAAGCACTTTGTTTTAAATAGGAGGGTTTCATAGTTGCATCTGAAGCCACCTG
 561 GTTCTGTTAAACTGTATGGTGCAGGTTTTGGGTTTGGCATTATTCATGTTTCTGATCAATTCTATGCAACTCTCATAGTT
 641 CCTGTTACTTTTTAGCATTAGCTGCCAAATGACTTCAAAAGGCTGGGGTGGGTGACTTGACTGTGAGACTGGATTATAAC
 721 ATGGACAAATCTTATTTTGCTTAATGTGTTTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTATGTATATATATATATA
 801 AATATCTTTCCCAATATGCCCCGTTGACAGTGTTTAAATTCCAGACTAGGACTGCTGATCTGCACAATTTAATTATGTGG
 881 TTATTCGAGCACTTAATTTCACTCAAGGTTCATTGGGCTCTGCTCTCCTCCCTGCCATTACGGGAGCTGTGGACAGAGCT
 961 CCCTCACTTCAAGATTCCTAGTGTTTTTGCACAACAGGTTGTCCAAGTGAGAAAGACTGAGTTGCGTGTCTGTAAATGTC
1041 TGCGCAGGGTGCACATGCTGCGAGGTCTCCATCCTCCGGGCCTGTCCCTCCCAGATGGGCTGGGCCTTTGGGCCCTCCTC
1121 AGAGTATGCCTGGGTACAAACCTCACTGTTCAGATGGGCTGTAAGTTCTCACTTCAAAGCTATGGAATGGATTTTAGCAC
1201 CTTTAAAAAAAAAAAAAACTTTGACTTTTAATTTATATAGTGATATGCTGACAGGCTGACACGCAGATGGTTTTGTCCTC
1281 TTTTCTGCGTTCAGTGTTGAGGCGGCTGCTTACAAGAGGCACTGGTTTTGTATATAAAGACACTCGGGTTGTTTTGTAGC
1361 TCTTTTTCTTATTGGCTGTACTAACGCTTGCTGAGGTTATCTGTAATAAGGGAGGTAACAAGTGGCAACCCCCTCCCCAC
1441 CAACCATCCCCTTTGCTGCTTTCTGTGTCTTTCTTGTTCAGTTACCAAAATAGCTGTAAGCCTATCTAATGCTAGGTGTG
1521 TGGACATTGTGCTAAGGTAGTTTCAGTGTGTCAACTTTATGAATTGAAATATAAACCAGTAAAATTGTATTACTGTTTCT
1601 TTTGTTGGTTTTATTTTAACAGCATATTGATTAAATATTTTGGTACAAACAAACA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' cuAUCUCAC-GUCUGGUCCCAga 5'
            || | || | |  ||||||  
Target 5' tgTA-AATGTCTGCGCAGGGTgc 3'
 1031 - 1052 127.00 -11.81
2 
miRNA  3' cuAUCUC----ACGUCUGGUCC--CAGa 5'
            ||| |    |||| | ||||  ||| 
Target 5' ccTAGTGTTTTTGCACAACAGGTTGTCc 3'
 977 - 1004 122.00 -9.50
3 
miRNA  3' cuauCUCACGU---CUGGUCCCAGa 5'
              |||| :|   ||:||| ||: 
Target 5' ggctGAGTTTACATGATCAGAGTTa 3'
 298 - 322 114.00 -10.60
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN31481676 28 COSMIC
COSN14370296 37 COSMIC
COSN30487828 53 COSMIC
COSN26991367 56 COSMIC
COSN26991364 74 COSMIC
COSN28750520 101 COSMIC
COSN8519937 101 COSMIC
COSN31487686 113 COSMIC
COSN30500436 133 COSMIC
COSN28824319 145 COSMIC
COSN30149045 150 COSMIC
COSN30531268 151 COSMIC
COSN30521546 167 COSMIC
COSN31557230 269 COSMIC
COSN30538246 411 COSMIC
COSN26563285 506 COSMIC
COSN28682796 613 COSMIC
COSN26640868 706 COSMIC
COSN31480489 732 COSMIC
COSN26547826 751 COSMIC
COSN19037701 757 COSMIC
COSN31521453 777 COSMIC
COSN7556030 779 COSMIC
COSN20557820 785 COSMIC
COSN28820851 789 COSMIC
COSN15002396 802 COSMIC
COSN31547899 807 COSMIC
COSN21834780 825 COSMIC
COSN19118544 930 COSMIC
COSN31538444 977 COSMIC
COSN31523554 981 COSMIC
COSN26641452 1121 COSMIC
COSN19664470 1205 COSMIC
COSN20106546 1219 COSMIC
COSN21184527 1251 COSMIC
COSN22048991 1480 COSMIC
rs700082 579 GWAS
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs774267585 2 dbSNP
rs745665070 12 dbSNP
rs749766384 13 dbSNP
rs775226641 15 dbSNP
rs1332116219 16 dbSNP
rs1226103345 17 dbSNP
rs993095223 19 dbSNP
rs915901878 20 dbSNP
rs1306880840 31 dbSNP
rs1218832352 35 dbSNP
rs1001872185 37 dbSNP
rs760201475 38 dbSNP
rs538715294 40 dbSNP
rs1267975389 41 dbSNP
rs1446314491 45 dbSNP
rs776067325 47 dbSNP
rs763417062 52 dbSNP
rs1478947509 53 dbSNP
rs948716240 55 dbSNP
rs1386446312 66 dbSNP
rs1160807600 70 dbSNP
rs1454712409 82 dbSNP
rs1380216941 84 dbSNP
rs1287449136 85 dbSNP
rs553873988 94 dbSNP
rs1395942302 99 dbSNP
rs1043547721 101 dbSNP
rs1356455265 102 dbSNP
rs1263873075 106 dbSNP
rs1205776519 111 dbSNP
rs1485541391 114 dbSNP
rs1283760807 115 dbSNP
rs771325222 116 dbSNP
rs571902598 117 dbSNP
rs1214930314 121 dbSNP
rs895474492 123 dbSNP
rs1348269012 124 dbSNP
rs542461458 131 dbSNP
rs993873333 135 dbSNP
rs1327700008 140 dbSNP
rs1238824451 142 dbSNP
rs12376606 145 dbSNP
rs1360515093 150 dbSNP
rs190973363 151 dbSNP
rs952468666 160 dbSNP
rs1436978659 163 dbSNP
rs1052249151 164 dbSNP
rs1376406211 166 dbSNP
rs892291362 166 dbSNP
rs983852835 167 dbSNP
rs1182438196 168 dbSNP
rs1018875855 169 dbSNP
rs1374972816 192 dbSNP
rs1380902625 193 dbSNP
rs1421374725 194 dbSNP
rs943992397 198 dbSNP
rs1260951976 202 dbSNP
rs1212850020 212 dbSNP
rs1040927092 213 dbSNP
rs112913331 214 dbSNP
rs1198487818 215 dbSNP
rs1341124648 227 dbSNP
rs1270401419 229 dbSNP
rs1156595443 230 dbSNP
rs964214522 231 dbSNP
rs899503939 232 dbSNP
rs977415089 232 dbSNP
rs935580518 237 dbSNP
rs1376572208 243 dbSNP
rs1333970133 251 dbSNP
rs1413118514 256 dbSNP
rs1398981052 258 dbSNP
rs1168649763 259 dbSNP
rs1465170398 266 dbSNP
rs1421519176 267 dbSNP
rs988132758 269 dbSNP
rs576220218 270 dbSNP
rs1336448289 275 dbSNP
rs1185222327 299 dbSNP
rs915225259 303 dbSNP
rs1273280524 305 dbSNP
rs996495076 307 dbSNP
rs1380852355 311 dbSNP
rs1452088896 315 dbSNP
rs1310005099 319 dbSNP
rs2416897 325 dbSNP
rs528175497 336 dbSNP
rs1238560381 338 dbSNP
rs1279363478 339 dbSNP
rs1274558550 341 dbSNP
rs1233330957 342 dbSNP
rs1045128029 344 dbSNP
rs1356731471 344 dbSNP
rs1346212931 356 dbSNP
rs1329826991 359 dbSNP
rs548218409 359 dbSNP
rs1202512102 364 dbSNP
rs1398346711 367 dbSNP
rs183162833 369 dbSNP
rs1161328357 370 dbSNP
rs1233197007 370 dbSNP
rs1254487984 370 dbSNP
rs1364599949 370 dbSNP
rs1413001274 370 dbSNP
rs1456200821 370 dbSNP
rs1462020630 370 dbSNP
rs1471058845 370 dbSNP
rs1213833884 374 dbSNP
rs1013681243 376 dbSNP
rs1193803025 376 dbSNP
rs1239898993 376 dbSNP
rs1280553703 376 dbSNP
rs1284835664 376 dbSNP
rs1287360718 376 dbSNP
rs1321533807 376 dbSNP
rs1349335241 376 dbSNP
rs1351881647 376 dbSNP
rs1375037747 376 dbSNP
rs1396522081 376 dbSNP
rs1402428293 376 dbSNP
rs1408587597 376 dbSNP
rs1437576489 376 dbSNP
rs1441745874 376 dbSNP
rs1442372437 376 dbSNP
rs1446463027 376 dbSNP
rs1449268989 376 dbSNP
rs1487890804 376 dbSNP
rs201605470 376 dbSNP
rs60381353 376 dbSNP
rs71508193 376 dbSNP
rs757803364 376 dbSNP
rs1305939922 377 dbSNP
rs1459689593 377 dbSNP
rs1202497131 378 dbSNP
rs1238178711 379 dbSNP
rs1432973369 380 dbSNP
rs4838030 380 dbSNP
rs1441495914 382 dbSNP
rs1179507201 384 dbSNP
rs1363133460 386 dbSNP
rs1377006246 386 dbSNP
rs1478273976 388 dbSNP
rs1174098804 389 dbSNP
rs1404207011 390 dbSNP
rs1432283300 390 dbSNP
rs1469427026 392 dbSNP
rs868311163 394 dbSNP
rs1402489805 396 dbSNP
rs1475446661 396 dbSNP
rs977553894 398 dbSNP
rs1216478973 400 dbSNP
rs1280867118 402 dbSNP
rs1282978748 402 dbSNP
rs1487526888 402 dbSNP
rs1311901202 404 dbSNP
rs1398957128 404 dbSNP
rs1276752762 406 dbSNP
rs1389722744 407 dbSNP
rs12002466 408 dbSNP
rs1328826425 408 dbSNP
rs1033174814 410 dbSNP
rs1156535520 411 dbSNP
rs1465353430 411 dbSNP
rs1357122137 412 dbSNP
rs1172007282 414 dbSNP
rs1410078156 416 dbSNP
rs1422226761 418 dbSNP
rs1190854875 420 dbSNP
rs1477152173 421 dbSNP
rs1182865411 422 dbSNP
rs1483096567 423 dbSNP
rs1332172222 424 dbSNP
rs1254488673 425 dbSNP
rs71388352 425 dbSNP
rs4271040 427 dbSNP
rs1206842338 429 dbSNP
rs1318720854 432 dbSNP
rs957842835 433 dbSNP
rs1257558017 435 dbSNP
rs1320974054 460 dbSNP
rs1336938493 472 dbSNP
rs888218514 476 dbSNP
rs1395250016 480 dbSNP
rs1003949511 486 dbSNP
rs1015812028 489 dbSNP
rs564698017 492 dbSNP
rs1193569605 500 dbSNP
rs1420669347 503 dbSNP
rs937151632 505 dbSNP
rs1423627418 509 dbSNP
rs1452056933 511 dbSNP
rs1254449852 518 dbSNP
rs993496934 521 dbSNP
rs1057363965 522 dbSNP
rs1023190004 530 dbSNP
rs970482891 542 dbSNP
rs1200745672 544 dbSNP
rs978757018 556 dbSNP
rs1469831925 560 dbSNP
rs1265962519 562 dbSNP
rs895769493 573 dbSNP
rs700082 579 dbSNP
rs547500292 580 dbSNP
rs934781294 591 dbSNP
rs1375768761 592 dbSNP
rs1328796969 598 dbSNP
rs988853206 606 dbSNP
rs1426016285 609 dbSNP
rs79929554 613 dbSNP
rs943851038 615 dbSNP
rs1457884546 617 dbSNP
rs1041372115 623 dbSNP
rs1367202275 624 dbSNP
rs1297666740 625 dbSNP
rs899723878 630 dbSNP
rs1379926746 635 dbSNP
rs139466608 636 dbSNP
rs549551846 649 dbSNP
rs1301708832 652 dbSNP
rs771753415 656 dbSNP
rs888112127 669 dbSNP
rs1400966318 672 dbSNP
rs964560353 688 dbSNP
rs1262410055 692 dbSNP
rs998401998 700 dbSNP
rs1352628154 701 dbSNP
rs1306672563 713 dbSNP
rs1235977458 716 dbSNP
rs1224632504 717 dbSNP
rs78270292 721 dbSNP
rs1015319639 723 dbSNP
rs895988391 727 dbSNP
rs1357009053 736 dbSNP
rs531873493 741 dbSNP
rs1360239203 743 dbSNP
rs956977180 744 dbSNP
rs1479154549 745 dbSNP
rs1266659306 747 dbSNP
rs1491128843 749 dbSNP
rs1491537104 750 dbSNP
rs10675843 751 dbSNP
rs1172145471 751 dbSNP
rs1288504786 751 dbSNP
rs1401200779 751 dbSNP
rs1403198061 751 dbSNP
rs1416509220 751 dbSNP
rs1425808256 751 dbSNP
rs1464637782 751 dbSNP
rs199564105 751 dbSNP
rs534514261 751 dbSNP
rs751557550 751 dbSNP
rs752423867 751 dbSNP
rs1194449115 755 dbSNP
rs986808125 757 dbSNP
rs915257652 763 dbSNP
rs1189429129 765 dbSNP
rs1442725183 765 dbSNP
rs1255047660 766 dbSNP
rs1340885420 767 dbSNP
rs967988982 767 dbSNP
rs1217480539 769 dbSNP
rs1258191939 769 dbSNP
rs1317900373 769 dbSNP
rs1276795037 771 dbSNP
rs1450641377 771 dbSNP
rs1333783428 773 dbSNP
rs1341407103 773 dbSNP
rs1394557053 775 dbSNP
rs1402686283 775 dbSNP
rs1320718509 777 dbSNP
rs1421401975 777 dbSNP
rs1465157031 777 dbSNP
rs879269609 778 dbSNP
rs1473020766 779 dbSNP
rs45448502 779 dbSNP
rs1185106572 781 dbSNP
rs567921044 781 dbSNP
rs803718 781 dbSNP
rs1243061402 783 dbSNP
rs45610639 783 dbSNP
rs200635574 785 dbSNP
rs746184562 785 dbSNP
rs1265686106 786 dbSNP
rs112214533 787 dbSNP
rs1321436868 787 dbSNP
rs5024052 787 dbSNP
rs1426900406 789 dbSNP
rs199627095 789 dbSNP
rs763105019 791 dbSNP
rs1369090525 794 dbSNP
rs71886032 797 dbSNP
rs1417527146 798 dbSNP
rs1459915669 798 dbSNP
rs867609871 800 dbSNP
rs397765359 801 dbSNP
rs57427538 801 dbSNP
rs1285877781 802 dbSNP
rs981267507 806 dbSNP
rs1365470177 807 dbSNP
rs1023536514 810 dbSNP
rs1489486059 811 dbSNP
rs1420756772 815 dbSNP
rs1300378052 818 dbSNP
rs1315418124 821 dbSNP
rs970366062 823 dbSNP
rs978975992 824 dbSNP
rs1366953799 825 dbSNP
rs1294260240 829 dbSNP
rs1056993480 833 dbSNP
rs1341021521 852 dbSNP
rs1033011896 855 dbSNP
rs192275604 858 dbSNP
rs1247497298 862 dbSNP
rs755317345 866 dbSNP
rs144202232 869 dbSNP
rs911951220 877 dbSNP
rs1413438698 884 dbSNP
rs1278109383 887 dbSNP
rs1046984983 891 dbSNP
rs888120087 893 dbSNP
rs1264517679 907 dbSNP
rs1479110349 907 dbSNP
rs1193415103 911 dbSNP
rs1005177238 914 dbSNP
rs144308284 920 dbSNP
rs1485033599 931 dbSNP
rs976634706 938 dbSNP
rs921082756 942 dbSNP
rs1029851485 943 dbSNP
rs760120121 951 dbSNP
rs932618032 964 dbSNP
rs1380316342 975 dbSNP
rs553847451 989 dbSNP
rs1048304022 995 dbSNP
rs768054560 1002 dbSNP
rs1446893143 1012 dbSNP
rs776624917 1015 dbSNP
rs1403399599 1019 dbSNP
rs1022464558 1023 dbSNP
rs909557949 1026 dbSNP
rs980829598 1027 dbSNP
rs565792806 1038 dbSNP
rs1427136152 1039 dbSNP
rs1160859296 1040 dbSNP
rs761711602 1042 dbSNP
rs536358886 1044 dbSNP
rs765056773 1045 dbSNP
rs1036803182 1047 dbSNP
rs992628177 1048 dbSNP
rs1257381044 1057 dbSNP
rs895591258 1062 dbSNP
rs1402466944 1063 dbSNP
rs1323405894 1066 dbSNP
rs1014408682 1075 dbSNP
rs146073595 1076 dbSNP
rs1312206121 1078 dbSNP
rs570901059 1079 dbSNP
rs183456315 1082 dbSNP
rs779191085 1083 dbSNP
rs1446930936 1084 dbSNP
rs748654611 1089 dbSNP
rs35562091 1094 dbSNP
rs543331542 1095 dbSNP
rs370018694 1101 dbSNP
rs909837808 1103 dbSNP
rs879111245 1114 dbSNP
rs1352119644 1120 dbSNP
rs1000405960 1121 dbSNP
rs1214765169 1123 dbSNP
rs941264600 1142 dbSNP
rs1256876286 1144 dbSNP
rs1033189491 1149 dbSNP
rs1462780011 1152 dbSNP
rs956053764 1158 dbSNP
rs1201860513 1161 dbSNP
rs1440423677 1162 dbSNP
rs899474672 1175 dbSNP
rs1194116238 1182 dbSNP
rs1489460309 1184 dbSNP
rs1242571242 1186 dbSNP
rs1265943867 1189 dbSNP
rs1440875859 1190 dbSNP
rs997960519 1195 dbSNP
rs1181109942 1197 dbSNP
rs1356960403 1197 dbSNP
rs1311032858 1202 dbSNP
rs1370377283 1205 dbSNP
rs200007649 1205 dbSNP
rs398087561 1205 dbSNP
rs57696888 1205 dbSNP
rs1294562061 1217 dbSNP
rs397687417 1219 dbSNP
rs777436715 1219 dbSNP
rs1050769677 1220 dbSNP
rs1364052259 1220 dbSNP
rs780327185 1220 dbSNP
rs1010168720 1224 dbSNP
rs537251247 1235 dbSNP
rs966179670 1238 dbSNP
rs975223025 1244 dbSNP
rs1022412493 1249 dbSNP
rs1352150290 1250 dbSNP
rs1470712692 1254 dbSNP
rs114550389 1263 dbSNP
rs541073736 1269 dbSNP
rs1489834295 1271 dbSNP
rs1287947378 1275 dbSNP
rs984053657 1276 dbSNP
rs1033703450 1278 dbSNP
rs960961796 1280 dbSNP
rs9032 1281 dbSNP
rs1312218998 1282 dbSNP
rs1302612786 1283 dbSNP
rs1371084736 1289 dbSNP
rs756155020 1290 dbSNP
rs1301639656 1294 dbSNP
rs1325967156 1295 dbSNP
rs529774405 1302 dbSNP
rs541922890 1304 dbSNP
rs561294094 1305 dbSNP
rs1400975461 1309 dbSNP
rs949871668 1314 dbSNP
rs1467671035 1336 dbSNP
rs1044499219 1343 dbSNP
rs982643846 1343 dbSNP
rs1458304318 1346 dbSNP
rs906039138 1347 dbSNP
rs1194136086 1352 dbSNP
rs1487802390 1360 dbSNP
rs531959926 1373 dbSNP
rs941307596 1378 dbSNP
rs1201764958 1379 dbSNP
rs1345252276 1382 dbSNP
rs1254945470 1383 dbSNP
rs1221150194 1386 dbSNP
rs550189994 1387 dbSNP
rs1280582529 1388 dbSNP
rs1054653107 1392 dbSNP
rs1480560792 1394 dbSNP
rs975709676 1399 dbSNP
rs1326167048 1415 dbSNP
rs1316653707 1417 dbSNP
rs892068974 1428 dbSNP
rs1431849383 1431 dbSNP
rs1481224020 1432 dbSNP
rs539920204 1434 dbSNP
rs754358202 1436 dbSNP
rs1465749073 1444 dbSNP
rs1425698238 1446 dbSNP
rs1171248946 1452 dbSNP
rs933613980 1457 dbSNP
rs1371172474 1459 dbSNP
rs1189318158 1464 dbSNP
rs571468298 1464 dbSNP
rs966436145 1465 dbSNP
rs996285474 1471 dbSNP
rs1029464201 1474 dbSNP
rs945116009 1482 dbSNP
rs532671855 1489 dbSNP
rs1171886413 1502 dbSNP
rs567609974 1504 dbSNP
rs757754801 1505 dbSNP
rs187997993 1528 dbSNP
rs1247431042 1529 dbSNP
rs1293919670 1541 dbSNP
rs191643272 1555 dbSNP
rs961318684 1559 dbSNP
rs1034312493 1568 dbSNP
rs1450584657 1573 dbSNP
rs745317023 1581 dbSNP
rs769432564 1586 dbSNP
rs1409340032 1592 dbSNP
rs377170528 1593 dbSNP
rs1394243176 1594 dbSNP
rs1013629400 1597 dbSNP
rs1164840226 1602 dbSNP
rs1318859257 1608 dbSNP
rs565753793 1609 dbSNP
rs950804154 1609 dbSNP
rs1181321222 1624 dbSNP
rs1441135493 1645 dbSNP
rs984852688 1645 dbSNP
rs1216419264 1648 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions Flp-In T-REx 293-hAGO1 cells
Location of target site 3'UTR
Original Description (Extracted from the article) ... Validation of interactions identified by CLASH suppports their reliability. ...

- Helwak A; Kudla G; Dudnakova T; Tollervey D, 2013, Cell.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' cuaUCUCACGUCU-GGUCCCAGa 5'
             | :||||||: :: ||||: 
Target 5' ---ATGGTGCAGGTTTTGGGTTt 3'
 		1 - 20
Article - Helwak A; Kudla G; Dudnakova T; Tollervey D
- Cell, 2013
MicroRNAs (miRNAs) play key roles in gene regulation, but reliable bioinformatic or experimental identification of their targets remains difficult. To provide an unbiased view of human miRNA targets, we developed a technique for ligation and sequencing of miRNA-target RNA duplexes associated with human AGO1. Here, we report data sets of more than 18,000 high-confidence miRNA-mRNA interactions. The binding of most miRNAs includes the 5' seed region, but around 60% of seed interactions are noncanonical, containing bulged or mismatched nucleotides. Moreover, seed interactions are generally accompanied by specific, nonseed base pairing. 18% of miRNA-mRNA interactions involve the miRNA 3' end, with little evidence for 5' contacts, and some of these were functionally validated. Analyses of miRNA:mRNA base pairing showed that miRNA species systematically differ in their target RNA interactions, and strongly overrepresented motifs were found in the interaction sites of several miRNAs. We speculate that these affect the response of RISC to miRNA-target binding.
LinkOut: [PMID: 23622248]
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
KIRC 0.38 0 0.324 0.01 51 Click to see details
BRCA -0.251 0.02 -0.269 0.02 65 Click to see details
COAD 0.877 0.03 1.000 0.5 5 Click to see details
STAD -0.38 0.03 -0.384 0.03 24 Click to see details
HNSC 0.333 0.04 0.246 0.1 28 Click to see details
THCA 0.195 0.09 0.228 0.06 49 Click to see details
KICH -0.274 0.09 -0.282 0.09 25 Click to see details
UCEC 0.329 0.12 0.239 0.2 15 Click to see details
ESCA -0.582 0.15 -0.600 0.14 5 Click to see details
PAAD 0.581 0.21 0.600 0.2 4 Click to see details
KIRP -0.155 0.22 -0.184 0.17 28 Click to see details
LIHC 0.119 0.22 0.043 0.39 43 Click to see details
CHOL 0.344 0.22 0.357 0.22 7 Click to see details
LUSC 0.139 0.24 0.119 0.27 29 Click to see details
LUAD -0.189 0.29 -0.182 0.3 11 Click to see details
BLCA 0.057 0.42 -0.226 0.22 14 Click to see details
PRAD 0.019 0.45 0.114 0.22 50 Click to see details
PRAD 0.019 0.45 0.114 0.22 50 Click to see details
PRAD 0.019 0.45 0.114 0.22 50 Click to see details
PRAD 0.019 0.45 0.114 0.22 50 Click to see details
PRAD 0.019 0.45 0.114 0.22 50 Click to see details
101 hsa-miR-504-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT000044 DRD1 dopamine receptor D1 2 1
MIRT004457 VEGFA vascular endothelial growth factor A 2 1
MIRT016249 BAX BCL2 associated X, apoptosis regulator 1 1
MIRT016251 GADD45A growth arrest and DNA damage inducible alpha 1 1
MIRT016252 FAS Fas cell surface death receptor 1 1
MIRT016253 BBC3 BCL2 binding component 3 1 1
MIRT016254 TP53I3 tumor protein p53 inducible protein 3 1 1
MIRT016255 TCEAL1 transcription elongation factor A like 1 2 1
MIRT016256 MDM2 MDM2 proto-oncogene 2 1
MIRT016257 TP53 tumor protein p53 3 1
MIRT041072 P2RY13 purinergic receptor P2Y13 1 1
MIRT041073 PPIL1 peptidylprolyl isomerase like 1 1 1
MIRT041074 ZNF814 zinc finger protein 814 1 1
MIRT041075 HIST1H2AC histone cluster 1 H2A family member c 1 1
MIRT041076 FEM1A fem-1 homolog A 1 1
MIRT041077 TXNRD1 thioredoxin reductase 1 1 1
MIRT041078 RAI1 retinoic acid induced 1 1 1
MIRT041079 SRRM2 serine/arginine repetitive matrix 2 1 1
MIRT041080 HNRNPAB heterogeneous nuclear ribonucleoprotein A/B 1 1
MIRT041081 PDLIM1 PDZ and LIM domain 1 1 1
MIRT041082 FAM208B family with sequence similarity 208 member B 1 1
MIRT041083 PSAT1 phosphoserine aminotransferase 1 1 1
MIRT041084 TMEM8A transmembrane protein 8A 1 1
MIRT041085 RABGAP1 RAB GTPase activating protein 1 1 1
MIRT041086 BRD2 bromodomain containing 2 1 1
MIRT041087 C11orf58 chromosome 11 open reading frame 58 1 1
MIRT041088 CNOT8 CCR4-NOT transcription complex subunit 8 1 1
MIRT041089 RPL10 ribosomal protein L10 1 1
MIRT041090 SMCR7L mitochondrial elongation factor 1 1 1
MIRT041091 CENPBD1 CENPB DNA-binding domain containing 1 1 1
MIRT041092 SF3B1 splicing factor 3b subunit 1 1 1
MIRT041093 MTFP1 mitochondrial fission process 1 1 1
MIRT438313 CDK6 cyclin dependent kinase 6 1 1
MIRT438352 TFF1 trefoil factor 1 3 1
MIRT443009 KBTBD12 kelch repeat and BTB domain containing 12 2 2
MIRT448052 SFRP1 secreted frizzled related protein 1 2 2
MIRT457649 ZNF69 zinc finger protein 69 2 2
MIRT458626 TRIM72 tripartite motif containing 72 2 2
MIRT466176 TMED5 transmembrane p24 trafficking protein 5 2 2
MIRT472583 NACC1 nucleus accumbens associated 1 2 2
MIRT473576 MAT2A methionine adenosyltransferase 2A 2 6
MIRT485155 RASL10B RAS like family 10 member B 2 2
MIRT490063 PRRT2 proline rich transmembrane protein 2 2 2
MIRT493015 NANOS1 nanos C2HC-type zinc finger 1 2 2
MIRT499425 PLCG2 phospholipase C gamma 2 2 11
MIRT506956 HOXB3 homeobox B3 2 4
MIRT507100 GPCPD1 glycerophosphocholine phosphodiesterase 1 2 2
MIRT508101 ANKRD33B ankyrin repeat domain 33B 2 4
MIRT522215 NR2C2 nuclear receptor subfamily 2 group C member 2 2 6
MIRT530327 TNFRSF10D TNF receptor superfamily member 10d 2 2
MIRT531042 ZNF502 zinc finger protein 502 2 2
MIRT532580 GSS glutathione synthetase 2 2
MIRT534841 RAB15 RAB15, member RAS oncogene family 2 2
MIRT536820 HMGN2 high mobility group nucleosomal binding domain 2 2 2
MIRT538303 CSNK2A1 casein kinase 2 alpha 1 2 2
MIRT546344 TFAP2C transcription factor AP-2 gamma 2 2
MIRT546704 RORA RAR related orphan receptor A 2 4
MIRT549222 BCL2L11 BCL2 like 11 2 4
MIRT549623 TMEM101 transmembrane protein 101 2 2
MIRT549931 NDUFB5 NADH:ubiquinone oxidoreductase subunit B5 2 2
MIRT550163 ZNF223 zinc finger protein 223 2 4
MIRT550555 ARSK arylsulfatase family member K 2 2
MIRT553402 TRIM2 tripartite motif containing 2 2 4
MIRT554084 SNX4 sorting nexin 4 2 4
MIRT556962 IER3IP1 immediate early response 3 interacting protein 1 2 2
MIRT558525 CSRNP3 cysteine and serine rich nuclear protein 3 2 2
MIRT558565 CRLF3 cytokine receptor like factor 3 2 4
MIRT560946 TPM4 tropomyosin 4 2 4
MIRT561628 SERBP1 SERPINE1 mRNA binding protein 1 2 2
MIRT562174 HOXA13 homeobox A13 2 2
MIRT568635 ACVR2A activin A receptor type 2A 2 2
MIRT574908 Plcg2 phospholipase C, gamma 2 2 7
MIRT575177 Atg9a autophagy related 9A 2 2
MIRT611972 PKD1 polycystin 1, transient receptor potential channel interacting 2 2
MIRT613623 CLASP1 cytoplasmic linker associated protein 1 2 4
MIRT635830 OPA3 OPA3, outer mitochondrial membrane lipid metabolism regulator 2 4
MIRT637344 DARS2 aspartyl-tRNA synthetase 2, mitochondrial 2 4
MIRT643205 JAK3 Janus kinase 3 2 2
MIRT650232 SIGLEC9 sialic acid binding Ig like lectin 9 2 2
MIRT655940 NDUFA4P1 NDUFA4, mitochondrial complex associated pseudogene 1 2 2
MIRT662021 ZNF445 zinc finger protein 445 2 2
MIRT662037 FUT2 fucosyltransferase 2 2 2
MIRT666873 POU2F2 POU class 2 homeobox 2 2 2
MIRT684310 TRUB2 TruB pseudouridine synthase family member 2 2 2
MIRT687333 OSMR oncostatin M receptor 2 2
MIRT689008 ATP6AP1 ATPase H+ transporting accessory protein 1 2 2
MIRT695137 PRY2 PTPN13-like, Y-linked 2 2 2
MIRT695154 PRY PTPN13-like, Y-linked 2 2
MIRT700695 POLR3D RNA polymerase III subunit D 2 2
MIRT703269 GNL3L G protein nucleolar 3 like 2 2
MIRT708941 CRY2 cryptochrome circadian clock 2 2 2
MIRT709200 SAPCD2 suppressor APC domain containing 2 2 2
MIRT709572 PDE4A phosphodiesterase 4A 2 2
MIRT711295 PSME3 proteasome activator subunit 3 2 2
MIRT712425 MACROD2 MACRO domain containing 2 2 2
MIRT713941 PIGR polymeric immunoglobulin receptor 2 2
MIRT714124 TMED9 transmembrane p24 trafficking protein 9 2 2
MIRT714630 KIAA1143 KIAA1143 2 2
MIRT724046 SMIM14 small integral membrane protein 14 2 2
MIRT724649 PKDREJ polycystin family receptor for egg jelly 2 2
MIRT725476 GRAP2 GRB2-related adaptor protein 2 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-504 Emodin NULL 3220 Microarray K562 cells 23744534 2013 down-regualted
miR-504 Mistletoe lectin-I NULL NULL Microarray colorectal cancer cells CLY cells 20955366 2011 down-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-504 Ceritinib 57379345 NSC776422 approved sensitive High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-mir-504 Androstenedione+Anastrozole resistant cell line (MCF-7)
hsa-mir-504 Ceritinib 57379345 NSC776422 approved sensitive cell line (H3122)
hsa-miR-504-5p Oxaliplatin 6857599 NSC266046 approved resistant High Colorectal Cancer cell line (HT-29)
hsa-miR-504-5p Oxaliplatin 6857599 NSC266046 approved sensitive High Colorectal Cancer cell line (RKO)
hsa-miR-504-5p Plx-4720 24180719 NSC757438 sensitive High Thyroid Cancer cell line (8505c, BCPAP)
hsa-miR-504-5p Vemurafenib 42611257 NSC761431 approved sensitive High Melanoma cell line (A375, IGR37, 501Mel)
hsa-miR-504-5p Dabrafenib 44462760 NSC764134 approved sensitive High Melanoma cell line (A375, IGR37, 501Mel)
hsa-miR-504-5p Dabrafenib 44462760 NSC764134 approved resistant High Melanoma cell line (A375, IGR37, 501Mel)
hsa-miR-504-5p Vemurafenib 42611257 NSC761431 approved resistant High Melanoma cell line (A375, IGR37, 501Mel)
hsa-miR-504-5p Ceritinib 57379345 NSC776422 approved sensitive High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-miR-504-5p Fulvestrant 17756771 NSC719276 approved sensitive High Breast Cancer cell line (MCF-7, MCF-7-TT)
hsa-miR-504-5p Gefitinib 123631 NSC715055 approved resistant cell line (PC9)
hsa-miR-504-5p Osimertinib 71496458 NSC779217 approved resistant cell line (PC9)
hsa-miR-504-5p Vemurafenib 42611257 NSC761431 approved resistant cell line (A375)
hsa-miR-504-5p Vemurafenib 42611257 NSC761431 approved sensitive cell line (451Lu)
hsa-miR-504-5p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-504-5p Vemurafenib 42611257 NSC761431 approved resistant cell line (LM47)
hsa-miR-504-5p Vemurafenib 42611257 NSC761431 approved sensitive cell line (LM16)
hsa-miR-504-5p Vemurafenib 42611257 NSC761431 approved resistant cell line (LM17)
hsa-miR-504-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (CIS)
hsa-miR-504-5p Cisplatin 5460033 NSC119875 approved resistant cell line (MGC-803)
hsa-miR-504-5p Ethanol+Tamoxifen sensitive cell line (LY2)
hsa-miR-504-5p Sunitinib 5329102 NSC750690 approved resistant tissue (CardA)
hsa-miR-504-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-504-5p Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (1500 ng/ml)
hsa-miR-504-5p Ceritinib 57379345 NSC776422 approved sensitive cell line (H3122)
hsa-miR-504-5p Cisplatin 5460033 NSC119875 approved resistant cell line (H460)

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