miRTarBase - #MIRT041089


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pre-miRNA Information
pre-miRNA hsa-mir-504   
Genomic Coordinates chrX: 138667711 - 138667793
Synonyms MIRN504, hsa-mir-504, MIR504
Description Homo sapiens miR-504 stem-loop
Comment The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies .
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-504-5p
Sequence 13| AGACCCUGGUCUGCACUCUAUC |34
Evidence Experimental
Experiments Array-cloned
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1297440872 6 dbSNP
rs1429220261 12 dbSNP
rs745623382 14 dbSNP
rs770027520 14 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol RPL10   
Synonyms AUTSX5, DXS648, DXS648E, L10, MRXS35, NOV, QM
Description ribosomal protein L10
Transcript NM_006013   
Expression
Putative miRNA Targets on RPL10
3'UTR of RPL10
(miRNA target sites are highlighted)		 
>RPL10|NM_006013|3'UTR
   1 GGGCTTCCAATGTGCTGCCCCCCTCTTAATACTCACCAATAAATTCTACTTCCTGTCCACCTATGTCTTTGTATCTACAT
  81 TCTTGACGGGGAAGGAACTTCCTCTGGGAACCTTTGGGTCATTGCCCTTTCACTTCAGAAACAGGTTGACAACTCAGCCC
 161 TGCTCATGAGGCAGCAAACCCTGCAAAGGGCTGGGACTGGTGGCCTTATGTCAGTTGTCTACTCTGGAGCTTGACTTGGA
 241 CCTCCCCAGGTCCTAGGCAGTAGGTTGAAAAACACTGAAGTGCTTTTCATGAAGCACAGCTGCAGCAAAGCCTTGCAATC
 321 CCAGGCTGGGGTCAGCCTACAGTTGTGTTGCTTATTACAACACATGCGGACCAAGAGGGGCTTGTGGGCTAGAGGCTGAC
 401 CAGCAGCGTTTATTTAGCAAGGGTAGGTGTGCATCACATTGGGCTTGTTCTCACCCATCTGGTTTGGCCATTCCTCCTTG
 481 GTGGGAATCATCCAGGTACTGCTGAGGTCACCTGCGATTTGCCCCATTTCCTATCTCTAGCAACCTCCTGGGCCCCATGC
 561 CCCCACCCCTTCTAGAACCTGCATTCCCAGGGCCTTCACCACCTGACCAAAGGTCTAGGCTAACCTTTGGTCATTTGTAA
 641 CAAGACCTCGGAACAGACACGTGTGTGGCATGGTTTGGCCTGGGGATCTTAGATGTCTGACCTGAACTATTGTAGAACAG
 721 CGCTGGCTTTTGGGGGAGCAGCAAAAATGAGAGGAGTGCTAGGTGGGTGGCCTGAGCATCTGTATCCAGGGACAGGACTC
 801 CAAAGGCTTTTGGTCCCAGAGCTGGGGTATGTTGGCCCCAGCCCCCAGCCTGTGGCTCCCAAAAGGCCTCTGGTTTTTTG
 881 TAATCTCAGTTTACAGCCATTTCTTAGGTTTTTAATTACCTTTATTTTATTTTGCCAAACATACCTGGGAATACCTTTTA
 961 TTTTTTTTTTACCTTGGGGTGATGGTTCCAAACCATAAATGTGATTATAGTTAACACATGACCCTTCTAGCGTCCCAGCC
1041 AGTGTTTTTCCTGACCTCTCTTCTTTGGAGAGGAGGATGGAAGGGAGGGGTCCGGCATGCTGCTGGCATTTTGCTGTGTC
1121 CTGCAGCCCCTTTCCGGGACACCTGGGTTCACACAGCTTTTTAGCTTACATAACTGGTGCAGATTTTCTGTGTGGAGATG
1201 TTGCCTTGACCAGCCTTGGCTGGACTTTACCAGGCATGCAGAAGCCTGTACCAACACAGACTACAGCACCCAGGAGGTGC
1281 GAGTGTGGCTGCTCAGCGGTTATAACAGGCCTGACTGCATTGTTCACCGGATTATAATGAGCCAAAATGTTTCCCGGTGT
1361 TTGCTGGTTTCAGGGAAGGAGTTTGATATAGCAGATTAACCACCCTCCTTGTAGCTATTGGGGCTTAATGGTTTCCTGGT
1441 GATTCTTACCAATCCACAATAAACATGGCCCATTGGCATATCTGCAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' cuaucucacGUCUGGUCCCAGa 5'
                   |||:|::||||| 
Target 5' ttgcaatccCAGGCTGGGGTCa 3'
 313 - 334 129.00 -18.80
2 
miRNA  3' cuAUCU--CACGU-CUGGUCCCAGa 5'
            ||||   ||||   |||||| | 
Target 5' tcTAGAACCTGCATTCCCAGGGCCt 3'
 571 - 595 126.00 -15.90
3 
miRNA  3' cuAUCUCACGUCUG---GUCCCAGa 5'
            ||||| || |||   ||| ||: 
Target 5' gcTAGAG-GCTGACCAGCAGCGTTt 3'
 388 - 411 119.00 -17.50
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
95326 3 ClinVar
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1281335081 2 dbSNP
rs369963498 3 dbSNP
rs937785442 11 dbSNP
rs1338060602 18 dbSNP
rs782601404 18 dbSNP
rs199538431 20 dbSNP
rs782330029 21 dbSNP
rs1415793083 23 dbSNP
rs782020205 23 dbSNP
rs55917222 24 dbSNP
rs782377085 29 dbSNP
rs1470357632 31 dbSNP
rs781882279 33 dbSNP
rs949049596 35 dbSNP
rs782085973 40 dbSNP
rs11547157 43 dbSNP
rs782750343 47 dbSNP
rs782154673 49 dbSNP
rs782769153 50 dbSNP
rs782787387 53 dbSNP
rs199985882 54 dbSNP
rs1353234109 58 dbSNP
rs782511430 62 dbSNP
rs1287022235 65 dbSNP
rs782639920 66 dbSNP
rs1409731458 68 dbSNP
rs781818881 74 dbSNP
rs1349384423 78 dbSNP
rs1312956120 79 dbSNP
rs782483082 80 dbSNP
rs782282641 88 dbSNP
rs782287421 88 dbSNP
rs374945049 89 dbSNP
rs782101776 89 dbSNP
rs782340670 91 dbSNP
rs1401106720 92 dbSNP
rs782643847 93 dbSNP
rs189433610 100 dbSNP
rs369038921 102 dbSNP
rs781973218 103 dbSNP
rs889620018 112 dbSNP
rs1156905558 116 dbSNP
rs782181769 121 dbSNP
rs782325175 122 dbSNP
rs782015571 131 dbSNP
rs1183683050 132 dbSNP
rs782160948 134 dbSNP
rs782754427 137 dbSNP
rs1216703284 143 dbSNP
rs782001431 144 dbSNP
rs782078103 153 dbSNP
rs782758857 164 dbSNP
rs192756674 166 dbSNP
rs1266595678 168 dbSNP
rs1228395050 179 dbSNP
rs782540746 182 dbSNP
rs782813115 184 dbSNP
rs1019671693 190 dbSNP
rs965327167 206 dbSNP
rs1336093971 213 dbSNP
rs1315374621 217 dbSNP
rs1229543530 218 dbSNP
rs1376295449 219 dbSNP
rs1301919065 221 dbSNP
rs1390644146 222 dbSNP
rs1430969870 222 dbSNP
rs1318279813 223 dbSNP
rs1456453095 225 dbSNP
rs989244209 230 dbSNP
rs1020523352 240 dbSNP
rs969413715 243 dbSNP
rs1422154655 244 dbSNP
rs1413132291 254 dbSNP
rs1187373954 260 dbSNP
rs1451558823 262 dbSNP
rs978952543 269 dbSNP
rs1208513834 270 dbSNP
rs1469134168 271 dbSNP
rs1267789095 274 dbSNP
rs1219945270 276 dbSNP
rs1319445248 277 dbSNP
rs1311382852 302 dbSNP
rs782542788 304 dbSNP
rs1228757918 317 dbSNP
rs868947782 318 dbSNP
rs782687399 319 dbSNP
rs1294859491 321 dbSNP
rs1434128212 322 dbSNP
rs937504003 323 dbSNP
rs990544329 328 dbSNP
rs917694665 349 dbSNP
rs1371394807 350 dbSNP
rs949019121 354 dbSNP
rs1295266239 358 dbSNP
rs782799479 359 dbSNP
rs60307723 368 dbSNP
rs184818061 369 dbSNP
rs1431645400 371 dbSNP
rs1388558163 375 dbSNP
rs1188124319 381 dbSNP
rs1454999000 382 dbSNP
rs190083836 392 dbSNP
rs73569595 408 dbSNP
rs889587500 409 dbSNP
rs1006697974 419 dbSNP
rs1252343653 421 dbSNP
rs1205256223 424 dbSNP
rs1343626144 428 dbSNP
rs1272067148 431 dbSNP
rs1227178717 432 dbSNP
rs1331507274 438 dbSNP
rs1303135050 441 dbSNP
rs181381143 443 dbSNP
rs901296786 455 dbSNP
rs41311384 457 dbSNP
rs782147064 463 dbSNP
rs1368732328 467 dbSNP
rs17423 469 dbSNP
rs1435566128 477 dbSNP
rs1379789701 479 dbSNP
rs1432898877 480 dbSNP
rs968753257 480 dbSNP
rs1251905421 487 dbSNP
rs1184903108 489 dbSNP
rs1483776318 492 dbSNP
rs782181852 492 dbSNP
rs1248941961 493 dbSNP
rs1000824671 495 dbSNP
rs1345272705 496 dbSNP
rs1034617343 511 dbSNP
rs1230803544 514 dbSNP
rs1311353886 516 dbSNP
rs782200890 517 dbSNP
rs993023693 518 dbSNP
rs1288935363 523 dbSNP
rs782418090 524 dbSNP
rs373460085 525 dbSNP
rs782491616 536 dbSNP
rs1348751957 539 dbSNP
rs1307483471 546 dbSNP
rs1396620237 548 dbSNP
rs1404623276 553 dbSNP
rs1301275148 555 dbSNP
rs1465872329 560 dbSNP
rs1413129820 566 dbSNP
rs1162045696 567 dbSNP
rs1471891868 568 dbSNP
rs782620172 569 dbSNP
rs1180849398 576 dbSNP
rs1442427273 579 dbSNP
rs782254751 580 dbSNP
rs1198325174 587 dbSNP
rs1482833340 589 dbSNP
rs1268494253 590 dbSNP
rs1230213805 597 dbSNP
rs782398895 600 dbSNP
rs782033311 609 dbSNP
rs781981678 614 dbSNP
rs1342290041 615 dbSNP
rs911162086 616 dbSNP
rs942525162 628 dbSNP
rs1310905682 646 dbSNP
rs1040891986 647 dbSNP
rs1395632776 650 dbSNP
rs782123213 657 dbSNP
rs1322960079 659 dbSNP
rs1455927168 661 dbSNP
rs782181908 662 dbSNP
rs1472854748 671 dbSNP
rs1369672245 674 dbSNP
rs1185013931 681 dbSNP
rs1422875368 685 dbSNP
rs901265826 687 dbSNP
rs1210360980 702 dbSNP
rs1010700600 703 dbSNP
rs1267451140 708 dbSNP
rs1210333985 712 dbSNP
rs1041816635 713 dbSNP
rs60050218 722 dbSNP
rs73638276 723 dbSNP
rs1366222188 724 dbSNP
rs1300018095 726 dbSNP
rs1034585454 735 dbSNP
rs1433392457 741 dbSNP
rs1324839769 749 dbSNP
rs782316114 749 dbSNP
rs1407546028 750 dbSNP
rs1392342038 757 dbSNP
rs1160961965 759 dbSNP
rs1423381526 771 dbSNP
rs1390436970 773 dbSNP
rs1190050062 775 dbSNP
rs1447481760 781 dbSNP
rs60187105 794 dbSNP
rs1453236874 795 dbSNP
rs782802366 798 dbSNP
rs1014427612 802 dbSNP
rs189484012 807 dbSNP
rs1277067729 808 dbSNP
rs34702445 808 dbSNP
rs1226432988 809 dbSNP
rs782508009 823 dbSNP
rs962243423 825 dbSNP
rs1439293339 827 dbSNP
rs972866984 828 dbSNP
rs1403820922 829 dbSNP
rs1370610981 838 dbSNP
rs782780102 848 dbSNP
rs952465998 853 dbSNP
rs983781225 857 dbSNP
rs868920804 868 dbSNP
rs1244947500 872 dbSNP
rs942661205 883 dbSNP
rs1483453291 884 dbSNP
rs781822230 888 dbSNP
rs1203363044 897 dbSNP
rs1482844478 899 dbSNP
rs782113490 900 dbSNP
rs1221323418 903 dbSNP
rs138357345 904 dbSNP
rs782795666 908 dbSNP
rs1343254177 920 dbSNP
rs1229514420 921 dbSNP
rs945917951 921 dbSNP
rs1350642898 931 dbSNP
rs782018519 936 dbSNP
rs1407386714 937 dbSNP
rs782165177 938 dbSNP
rs370521179 939 dbSNP
rs1334360234 940 dbSNP
rs111304980 941 dbSNP
rs369000820 941 dbSNP
rs782019336 941 dbSNP
rs1422778553 944 dbSNP
rs868930453 948 dbSNP
rs868987897 949 dbSNP
rs1175668115 955 dbSNP
rs1472875553 961 dbSNP
rs34768106 961 dbSNP
rs782190291 961 dbSNP
rs782705148 971 dbSNP
rs1469655119 973 dbSNP
rs1212484244 986 dbSNP
rs1441086581 995 dbSNP
rs894481836 1006 dbSNP
rs868907608 1019 dbSNP
rs1209961393 1023 dbSNP
rs1331853590 1028 dbSNP
rs1286926412 1030 dbSNP
rs1226077844 1031 dbSNP
rs181865290 1032 dbSNP
rs149274235 1033 dbSNP
rs1024575677 1041 dbSNP
rs1449732332 1042 dbSNP
rs782368366 1042 dbSNP
rs1357283456 1054 dbSNP
rs1335825705 1056 dbSNP
rs782243944 1056 dbSNP
rs1457523342 1059 dbSNP
rs12877 1061 dbSNP
rs1418628485 1070 dbSNP
rs1414587257 1076 dbSNP
rs1183883010 1078 dbSNP
rs1471923221 1084 dbSNP
rs1189613338 1090 dbSNP
rs1242697210 1090 dbSNP
rs782480096 1091 dbSNP
rs1215683074 1094 dbSNP
rs186070063 1095 dbSNP
rs1229733979 1098 dbSNP
rs12559 1099 dbSNP
rs1313839451 1100 dbSNP
rs1435571042 1101 dbSNP
rs1367065415 1108 dbSNP
rs1318505391 1114 dbSNP
rs1452960462 1116 dbSNP
rs1350595046 1122 dbSNP
rs983750224 1136 dbSNP
rs781848424 1137 dbSNP
rs1017859375 1139 dbSNP
rs963691123 1143 dbSNP
rs976613073 1147 dbSNP
rs77896655 1158 dbSNP
rs782507422 1166 dbSNP
rs143602122 1170 dbSNP
rs782280308 1171 dbSNP
rs782333009 1175 dbSNP
rs1246545515 1187 dbSNP
rs782020456 1193 dbSNP
rs1186519349 1201 dbSNP
rs190972847 1204 dbSNP
rs1223136104 1212 dbSNP
rs11322907 1225 dbSNP
rs926027140 1230 dbSNP
rs1290640374 1240 dbSNP
rs1228642624 1242 dbSNP
rs1344130269 1248 dbSNP
rs1293157256 1250 dbSNP
rs1381381406 1254 dbSNP
rs1368218849 1271 dbSNP
rs1295173665 1275 dbSNP
rs782767489 1281 dbSNP
rs1365016792 1283 dbSNP
rs1169513228 1295 dbSNP
rs1431860911 1298 dbSNP
rs1388770342 1299 dbSNP
rs1170206283 1303 dbSNP
rs1434059969 1306 dbSNP
rs936031114 1307 dbSNP
rs1427906940 1309 dbSNP
rs1189960244 1320 dbSNP
rs1055896175 1329 dbSNP
rs1267552040 1330 dbSNP
rs1205501514 1332 dbSNP
rs183061117 1336 dbSNP
rs1249186995 1337 dbSNP
rs41311694 1343 dbSNP
rs374225000 1345 dbSNP
rs138408303 1346 dbSNP
rs1303387175 1350 dbSNP
rs1221583724 1356 dbSNP
rs142707391 1364 dbSNP
rs1804566 1373 dbSNP
rs1308705395 1385 dbSNP
rs374265212 1388 dbSNP
rs994065652 1389 dbSNP
rs1394613790 1398 dbSNP
rs1297784493 1404 dbSNP
rs1466897028 1407 dbSNP
rs1361228629 1418 dbSNP
rs1174655439 1427 dbSNP
rs782446517 1438 dbSNP
rs782805035 1451 dbSNP
rs111424017 1452 dbSNP
rs1413263607 1454 dbSNP
rs1182269781 1458 dbSNP
rs190646141 1477 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions Flp-In T-REx 293-hAGO1 cells
Location of target site CDS
Original Description (Extracted from the article) ... Validation of interactions identified by CLASH suppports their reliability. ...

- Helwak A; Kudla G; Dudnakova T; Tollervey D, 2013, Cell.

Article - Helwak A; Kudla G; Dudnakova T; Tollervey D
- Cell, 2013
MicroRNAs (miRNAs) play key roles in gene regulation, but reliable bioinformatic or experimental identification of their targets remains difficult. To provide an unbiased view of human miRNA targets, we developed a technique for ligation and sequencing of miRNA-target RNA duplexes associated with human AGO1. Here, we report data sets of more than 18,000 high-confidence miRNA-mRNA interactions. The binding of most miRNAs includes the 5' seed region, but around 60% of seed interactions are noncanonical, containing bulged or mismatched nucleotides. Moreover, seed interactions are generally accompanied by specific, nonseed base pairing. 18% of miRNA-mRNA interactions involve the miRNA 3' end, with little evidence for 5' contacts, and some of these were functionally validated. Analyses of miRNA:mRNA base pairing showed that miRNA species systematically differ in their target RNA interactions, and strongly overrepresented motifs were found in the interaction sites of several miRNAs. We speculate that these affect the response of RISC to miRNA-target binding.
LinkOut: [PMID: 23622248]
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
LIHC 0.353 0.01 0.370 0.01 43 Click to see details
KIRC 0.234 0.05 0.247 0.04 51 Click to see details
KIRP 0.3 0.06 0.238 0.11 28 Click to see details
KICH 0.316 0.06 0.362 0.04 25 Click to see details
COAD -0.687 0.1 -0.600 0.14 5 Click to see details
PAAD 0.746 0.13 0.400 0.3 4 Click to see details
STAD -0.164 0.22 -0.264 0.11 24 Click to see details
HNSC -0.123 0.27 -0.138 0.24 28 Click to see details
UCEC 0.163 0.28 0.196 0.24 15 Click to see details
BRCA -0.064 0.31 -0.079 0.27 65 Click to see details
ESCA -0.294 0.32 -0.300 0.31 5 Click to see details
LUSC 0.072 0.36 0.088 0.32 29 Click to see details
CHOL 0.163 0.36 0.357 0.22 7 Click to see details
PRAD 0.05 0.37 0.033 0.41 50 Click to see details
LUAD 0.072 0.42 0.245 0.23 11 Click to see details
BLCA 0.059 0.42 0.165 0.29 14 Click to see details
THCA -0.014 0.46 -0.050 0.37 49 Click to see details
THCA -0.014 0.46 -0.050 0.37 49 Click to see details
THCA -0.014 0.46 -0.050 0.37 49 Click to see details
THCA -0.014 0.46 -0.050 0.37 49 Click to see details
THCA -0.014 0.46 -0.050 0.37 49 Click to see details
101 hsa-miR-504-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT000044 DRD1 dopamine receptor D1 2 1
MIRT004457 VEGFA vascular endothelial growth factor A 2 1
MIRT016249 BAX BCL2 associated X, apoptosis regulator 1 1
MIRT016251 GADD45A growth arrest and DNA damage inducible alpha 1 1
MIRT016252 FAS Fas cell surface death receptor 1 1
MIRT016253 BBC3 BCL2 binding component 3 1 1
MIRT016254 TP53I3 tumor protein p53 inducible protein 3 1 1
MIRT016255 TCEAL1 transcription elongation factor A like 1 2 1
MIRT016256 MDM2 MDM2 proto-oncogene 2 1
MIRT016257 TP53 tumor protein p53 3 1
MIRT041072 P2RY13 purinergic receptor P2Y13 1 1
MIRT041073 PPIL1 peptidylprolyl isomerase like 1 1 1
MIRT041074 ZNF814 zinc finger protein 814 1 1
MIRT041075 HIST1H2AC histone cluster 1 H2A family member c 1 1
MIRT041076 FEM1A fem-1 homolog A 1 1
MIRT041077 TXNRD1 thioredoxin reductase 1 1 1
MIRT041078 RAI1 retinoic acid induced 1 1 1
MIRT041079 SRRM2 serine/arginine repetitive matrix 2 1 1
MIRT041080 HNRNPAB heterogeneous nuclear ribonucleoprotein A/B 1 1
MIRT041081 PDLIM1 PDZ and LIM domain 1 1 1
MIRT041082 FAM208B family with sequence similarity 208 member B 1 1
MIRT041083 PSAT1 phosphoserine aminotransferase 1 1 1
MIRT041084 TMEM8A transmembrane protein 8A 1 1
MIRT041085 RABGAP1 RAB GTPase activating protein 1 1 1
MIRT041086 BRD2 bromodomain containing 2 1 1
MIRT041087 C11orf58 chromosome 11 open reading frame 58 1 1
MIRT041088 CNOT8 CCR4-NOT transcription complex subunit 8 1 1
MIRT041089 RPL10 ribosomal protein L10 1 1
MIRT041090 SMCR7L mitochondrial elongation factor 1 1 1
MIRT041091 CENPBD1 CENPB DNA-binding domain containing 1 1 1
MIRT041092 SF3B1 splicing factor 3b subunit 1 1 1
MIRT041093 MTFP1 mitochondrial fission process 1 1 1
MIRT438313 CDK6 cyclin dependent kinase 6 1 1
MIRT438352 TFF1 trefoil factor 1 3 1
MIRT443009 KBTBD12 kelch repeat and BTB domain containing 12 2 2
MIRT448052 SFRP1 secreted frizzled related protein 1 2 2
MIRT457649 ZNF69 zinc finger protein 69 2 2
MIRT458626 TRIM72 tripartite motif containing 72 2 2
MIRT466176 TMED5 transmembrane p24 trafficking protein 5 2 2
MIRT472583 NACC1 nucleus accumbens associated 1 2 2
MIRT473576 MAT2A methionine adenosyltransferase 2A 2 6
MIRT485155 RASL10B RAS like family 10 member B 2 2
MIRT490063 PRRT2 proline rich transmembrane protein 2 2 2
MIRT493015 NANOS1 nanos C2HC-type zinc finger 1 2 2
MIRT499425 PLCG2 phospholipase C gamma 2 2 11
MIRT506956 HOXB3 homeobox B3 2 4
MIRT507100 GPCPD1 glycerophosphocholine phosphodiesterase 1 2 2
MIRT508101 ANKRD33B ankyrin repeat domain 33B 2 4
MIRT522215 NR2C2 nuclear receptor subfamily 2 group C member 2 2 6
MIRT530327 TNFRSF10D TNF receptor superfamily member 10d 2 2
MIRT531042 ZNF502 zinc finger protein 502 2 2
MIRT532580 GSS glutathione synthetase 2 2
MIRT534841 RAB15 RAB15, member RAS oncogene family 2 2
MIRT536820 HMGN2 high mobility group nucleosomal binding domain 2 2 2
MIRT538303 CSNK2A1 casein kinase 2 alpha 1 2 2
MIRT546344 TFAP2C transcription factor AP-2 gamma 2 2
MIRT546704 RORA RAR related orphan receptor A 2 4
MIRT549222 BCL2L11 BCL2 like 11 2 4
MIRT549623 TMEM101 transmembrane protein 101 2 2
MIRT549931 NDUFB5 NADH:ubiquinone oxidoreductase subunit B5 2 2
MIRT550163 ZNF223 zinc finger protein 223 2 4
MIRT550555 ARSK arylsulfatase family member K 2 2
MIRT553402 TRIM2 tripartite motif containing 2 2 4
MIRT554084 SNX4 sorting nexin 4 2 4
MIRT556962 IER3IP1 immediate early response 3 interacting protein 1 2 2
MIRT558525 CSRNP3 cysteine and serine rich nuclear protein 3 2 2
MIRT558565 CRLF3 cytokine receptor like factor 3 2 4
MIRT560946 TPM4 tropomyosin 4 2 4
MIRT561628 SERBP1 SERPINE1 mRNA binding protein 1 2 2
MIRT562174 HOXA13 homeobox A13 2 2
MIRT568635 ACVR2A activin A receptor type 2A 2 2
MIRT574908 Plcg2 phospholipase C, gamma 2 2 7
MIRT575177 Atg9a autophagy related 9A 2 2
MIRT611972 PKD1 polycystin 1, transient receptor potential channel interacting 2 2
MIRT613623 CLASP1 cytoplasmic linker associated protein 1 2 4
MIRT635830 OPA3 OPA3, outer mitochondrial membrane lipid metabolism regulator 2 4
MIRT637344 DARS2 aspartyl-tRNA synthetase 2, mitochondrial 2 4
MIRT643205 JAK3 Janus kinase 3 2 2
MIRT650232 SIGLEC9 sialic acid binding Ig like lectin 9 2 2
MIRT655940 NDUFA4P1 NDUFA4, mitochondrial complex associated pseudogene 1 2 2
MIRT662021 ZNF445 zinc finger protein 445 2 2
MIRT662037 FUT2 fucosyltransferase 2 2 2
MIRT666873 POU2F2 POU class 2 homeobox 2 2 2
MIRT684310 TRUB2 TruB pseudouridine synthase family member 2 2 2
MIRT687333 OSMR oncostatin M receptor 2 2
MIRT689008 ATP6AP1 ATPase H+ transporting accessory protein 1 2 2
MIRT695137 PRY2 PTPN13-like, Y-linked 2 2 2
MIRT695154 PRY PTPN13-like, Y-linked 2 2
MIRT700695 POLR3D RNA polymerase III subunit D 2 2
MIRT703269 GNL3L G protein nucleolar 3 like 2 2
MIRT708941 CRY2 cryptochrome circadian clock 2 2 2
MIRT709200 SAPCD2 suppressor APC domain containing 2 2 2
MIRT709572 PDE4A phosphodiesterase 4A 2 2
MIRT711295 PSME3 proteasome activator subunit 3 2 2
MIRT712425 MACROD2 MACRO domain containing 2 2 2
MIRT713941 PIGR polymeric immunoglobulin receptor 2 2
MIRT714124 TMED9 transmembrane p24 trafficking protein 9 2 2
MIRT714630 KIAA1143 KIAA1143 2 2
MIRT724046 SMIM14 small integral membrane protein 14 2 2
MIRT724649 PKDREJ polycystin family receptor for egg jelly 2 2
MIRT725476 GRAP2 GRB2-related adaptor protein 2 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-504 Emodin NULL 3220 Microarray K562 cells 23744534 2013 down-regualted
miR-504 Mistletoe lectin-I NULL NULL Microarray colorectal cancer cells CLY cells 20955366 2011 down-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-504 Ceritinib 57379345 NSC776422 approved sensitive High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-mir-504 Androstenedione+Anastrozole resistant cell line (MCF-7)
hsa-mir-504 Ceritinib 57379345 NSC776422 approved sensitive cell line (H3122)
hsa-miR-504-5p Oxaliplatin 6857599 NSC266046 approved resistant High Colorectal Cancer cell line (HT-29)
hsa-miR-504-5p Oxaliplatin 6857599 NSC266046 approved sensitive High Colorectal Cancer cell line (RKO)
hsa-miR-504-5p Plx-4720 24180719 NSC757438 sensitive High Thyroid Cancer cell line (8505c, BCPAP)
hsa-miR-504-5p Vemurafenib 42611257 NSC761431 approved sensitive High Melanoma cell line (A375, IGR37, 501Mel)
hsa-miR-504-5p Dabrafenib 44462760 NSC764134 approved sensitive High Melanoma cell line (A375, IGR37, 501Mel)
hsa-miR-504-5p Dabrafenib 44462760 NSC764134 approved resistant High Melanoma cell line (A375, IGR37, 501Mel)
hsa-miR-504-5p Vemurafenib 42611257 NSC761431 approved resistant High Melanoma cell line (A375, IGR37, 501Mel)
hsa-miR-504-5p Ceritinib 57379345 NSC776422 approved sensitive High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-miR-504-5p Fulvestrant 17756771 NSC719276 approved sensitive High Breast Cancer cell line (MCF-7, MCF-7-TT)
hsa-miR-504-5p Gefitinib 123631 NSC715055 approved resistant cell line (PC9)
hsa-miR-504-5p Osimertinib 71496458 NSC779217 approved resistant cell line (PC9)
hsa-miR-504-5p Vemurafenib 42611257 NSC761431 approved resistant cell line (A375)
hsa-miR-504-5p Vemurafenib 42611257 NSC761431 approved sensitive cell line (451Lu)
hsa-miR-504-5p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-504-5p Vemurafenib 42611257 NSC761431 approved resistant cell line (LM47)
hsa-miR-504-5p Vemurafenib 42611257 NSC761431 approved sensitive cell line (LM16)
hsa-miR-504-5p Vemurafenib 42611257 NSC761431 approved resistant cell line (LM17)
hsa-miR-504-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (CIS)
hsa-miR-504-5p Cisplatin 5460033 NSC119875 approved resistant cell line (MGC-803)
hsa-miR-504-5p Ethanol+Tamoxifen sensitive cell line (LY2)
hsa-miR-504-5p Sunitinib 5329102 NSC750690 approved resistant tissue (CardA)
hsa-miR-504-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-504-5p Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (1500 ng/ml)
hsa-miR-504-5p Ceritinib 57379345 NSC776422 approved sensitive cell line (H3122)
hsa-miR-504-5p Cisplatin 5460033 NSC119875 approved resistant cell line (H460)

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