miRTarBase - #MIRT041091


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pre-miRNA Information
pre-miRNA hsa-mir-504   
Genomic Coordinates chrX: 138667711 - 138667793
Synonyms MIRN504, hsa-mir-504, MIR504
Description Homo sapiens miR-504 stem-loop
Comment The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies .
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-504-5p
Sequence 13| AGACCCUGGUCUGCACUCUAUC |34
Evidence Experimental
Experiments Array-cloned
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1297440872 6 dbSNP
rs1429220261 12 dbSNP
rs745623382 14 dbSNP
rs770027520 14 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol CENPBD1   
Synonyms -
Description CENPB DNA-binding domain containing 1
Transcript NM_145039   
Expression
Putative miRNA Targets on CENPBD1
3'UTR of CENPBD1
(miRNA target sites are highlighted)		 
>CENPBD1|NM_145039|3'UTR
   1 ATGAGACGAGACTTGATTGGAAGAGAATGCCCAAAGGAACGTTTATTTCCGAGGAAGAGAATGCTGAGCCAGGGTTTAAG
  81 TCATCCAAAGATCGCTTGATGCTGCTGCTTGGTGGCAGTGCAGCTGGGGACTTTAAGTTGAAGCCCTTACTGGTGTACCG
 161 CTCAGAAACCCGCAAGGCTCTGAAGGGTTCTTGAAGCCCAGTTTGCCCGTGATTTGGCGCTCCAACAGAAAGGCTTGGGT
 241 GACCAGGAGCATCTTTCATGAATGGTTCACTTACTTTTTTTGCCGTTGAAAAATACAGTGCCCAAAATAATCTCACCAAC
 321 AAAGCACTGCTCATACTAGACAGTGCGTCATGCCACTCTGTAAATTTGAGCGACCTTTCTGATAACTAAGAGTAGAATAC
 401 CTTCAGGCCAGGCGCGGTGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGACGGGCGGATCACCTGAGGTCAGG
 481 AGTTCGAGACCAGCCTCAACATGGAGAAACCCCGTCTCTATTAAAAATACAAATTTAGCCGGGCGTGGTGGTGCAGGCCT
 561 GTAATCCCAGCTACTCGGGAGGCTAAAGCAGGAGAATTGCTTGAACCTGGGAGGCGGAGGTTGTGGTGAGCCGAGATCGC
 641 GCCATTGCACTCCATCCTGGACAACAGGAGTGAAACTCCGTCTCAAAAAAAAAAAAGAAAAAAAAGAAGTACAAGAGTAT
 721 AATACCTTCATGACAGTACAGCTGACTCAATCCGGACCACGTGTCAAGGTGTAATCTCGACCTTGAAAGCTCATTATCTG
 801 AGAAGGACTTTTCAGCACATCCTAGAAGCAGCGGATGGTGAGGACACAGCTATGATCAGGGAATTTTGGAGAAACTACAG
 881 CATCATGGATGCTGTGGACATGGCCATCGCATGGGAGGAGCTCAAACCAGCACTAATGAACAGCATGTGGAAGAAGATTT
 961 GGCCTGAGTGTGTTCAGGCCCAGCGTTTTTCCCAGGCAGATAACATTGCACAGCTTCAAAAAAACATTGTGACCCTTGCC
1041 AGAAATGTGGCCTTTGAAGAGGTTGCTGAGGCTGCTGTGGACCAGTTGCTGCAGTCCCATGAAGAAGATCTCTCAAATGA
1121 GGAACTGATGCGGCTGGAACAGGAGCTGGCAGTGGGGGAGGAGGAGAGGGAAGATGGTCCCTGGGCACTGTGGCAGCTAA
1201 CCACAGGAAGACTGTCGGCAGCCCTCTCACATTTTGAGGCTGGCTTGTAGGTCCTTGCTAGTAACAGCCCTAATGATGAC
1281 TGGAAACTGAGAGGTTCCAGAGAAATCAGTGTTGCAGTAAACTGCTAGCAGGAGCTGTACAATGAGAAAAAGCGCCACTC
1361 AAAACAACTCTCTTAGGTCATTTTTCAATGTGTGTAACCAAAAGTTAATCAGAATAAAGCGGAAGCACCATGATGACCTC
1441 AACAGTGGAGGCCCAGCCAGGCCTCCCTGCTCTGTGGTGTTGGACATCCCTGGAAACCTTGCTGTTGGTATTTCCATTTT
1521 GATACTTGAGAGCATCAAATTTTGTCATTAAAATGTTATTTAAATATATGCTTTTAAAAGCTCAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' cuaUCUCACGUCU-GGUCCCAGa 5'
             ||| ||| || |||||||: 
Target 5' aagAGAATGCTGAGCCAGGGTTt 3'
 55 - 77 155.00 -22.70
2 
miRNA  3' cuaUCUCAC--GUCU-GGUCCCAGa 5'
             || |||  |||: |||| ||: 
Target 5' ctgAGTGTGTTCAGGCCCAGCGTTt 3'
 964 - 988 117.00 -15.90
3 
miRNA  3' cuaucucacguCUGGUCCCaga 5'
                     ||:|||||   
Target 5' gacacagctatGATCAGGGaat 3'
 843 - 864 111.00 -13.82
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30137357 2 COSMIC
COSN31540790 29 COSMIC
COSN30134021 32 COSMIC
COSN31538590 73 COSMIC
COSN31581373 93 COSMIC
COSN23386515 847 COSMIC
COSM7714703 1017 COSMIC
COSM3957941 1104 COSMIC
COSM6304924 1114 COSMIC
COSM7242279 1161 COSMIC
COSM7242447 1173 COSMIC
COSN6098140 1421 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1275015000 1 dbSNP
rs1394294235 3 dbSNP
rs754347164 5 dbSNP
rs1338149414 7 dbSNP
rs1256032890 8 dbSNP
rs150454958 15 dbSNP
rs1402726004 20 dbSNP
rs1021489044 21 dbSNP
rs1320903206 23 dbSNP
rs1281774886 25 dbSNP
rs1279655541 27 dbSNP
rs1404714664 29 dbSNP
rs760931059 30 dbSNP
rs1331434024 39 dbSNP
rs1389782281 40 dbSNP
rs1011403616 41 dbSNP
rs1395896989 42 dbSNP
rs1022122888 47 dbSNP
rs1471084822 49 dbSNP
rs1427459763 50 dbSNP
rs540807844 54 dbSNP
rs1489949960 56 dbSNP
rs1196139755 65 dbSNP
rs556483248 73 dbSNP
rs1440300454 74 dbSNP
rs764946649 75 dbSNP
rs114766989 77 dbSNP
rs998484878 80 dbSNP
rs1462673413 85 dbSNP
rs1256846816 86 dbSNP
rs752939725 93 dbSNP
rs1422464757 95 dbSNP
rs1039117163 99 dbSNP
rs1037069790 102 dbSNP
rs1360814655 105 dbSNP
rs1381289794 107 dbSNP
rs1292840560 121 dbSNP
rs1004005236 129 dbSNP
rs1314898812 131 dbSNP
rs888190731 144 dbSNP
rs1219294344 152 dbSNP
rs943040732 154 dbSNP
rs1488121945 159 dbSNP
rs888066281 160 dbSNP
rs1241322435 161 dbSNP
rs13336336 171 dbSNP
rs1307677487 173 dbSNP
rs1443037743 178 dbSNP
rs140564976 179 dbSNP
rs1442666667 182 dbSNP
rs372029700 185 dbSNP
rs1286478634 187 dbSNP
rs919441178 191 dbSNP
rs114824640 192 dbSNP
rs1286714680 200 dbSNP
rs1242159706 204 dbSNP
rs1396152123 205 dbSNP
rs184091793 213 dbSNP
rs939565831 220 dbSNP
rs939436895 225 dbSNP
rs1310470537 232 dbSNP
rs927990507 237 dbSNP
rs978060359 243 dbSNP
rs1257933464 244 dbSNP
rs1483689381 245 dbSNP
rs1203159293 247 dbSNP
rs1241353313 251 dbSNP
rs1459935246 254 dbSNP
rs1160303609 258 dbSNP
rs370867077 262 dbSNP
rs1238592205 264 dbSNP
rs1379641701 270 dbSNP
rs915313689 271 dbSNP
rs926694036 274 dbSNP
rs1379045603 276 dbSNP
rs368104135 283 dbSNP
rs576262626 284 dbSNP
rs1021521581 285 dbSNP
rs1332587719 286 dbSNP
rs990038756 288 dbSNP
rs547266498 292 dbSNP
rs1390078637 296 dbSNP
rs771478580 300 dbSNP
rs529150474 302 dbSNP
rs1244032043 320 dbSNP
rs1223122475 324 dbSNP
rs1217867064 330 dbSNP
rs766995411 332 dbSNP
rs1320043967 334 dbSNP
rs1031924645 337 dbSNP
rs1200476149 346 dbSNP
rs1251866649 348 dbSNP
rs191805159 350 dbSNP
rs1015295757 353 dbSNP
rs1269181543 359 dbSNP
rs1480565403 368 dbSNP
rs1248718458 371 dbSNP
rs550111677 375 dbSNP
rs888223366 384 dbSNP
rs1170752801 386 dbSNP
rs1354512022 387 dbSNP
rs1312881434 388 dbSNP
rs1394940909 393 dbSNP
rs1017348809 395 dbSNP
rs1048191199 396 dbSNP
rs1281557956 397 dbSNP
rs1012642762 400 dbSNP
rs531299941 401 dbSNP
rs1400420211 405 dbSNP
rs1272365455 409 dbSNP
rs1306903621 414 dbSNP
rs895325207 415 dbSNP
rs563950360 416 dbSNP
rs1267001195 418 dbSNP
rs1055663810 419 dbSNP
rs1490441727 420 dbSNP
rs939656888 426 dbSNP
rs928196585 440 dbSNP
rs1042396437 445 dbSNP
rs546639303 449 dbSNP
rs1156796259 453 dbSNP
rs1459436815 454 dbSNP
rs887427231 458 dbSNP
rs1427274467 459 dbSNP
rs1167477428 461 dbSNP
rs1350854775 463 dbSNP
rs1368985310 465 dbSNP
rs1164223942 470 dbSNP
rs1048731380 472 dbSNP
rs1400818652 476 dbSNP
rs993769147 476 dbSNP
rs146873515 477 dbSNP
rs898043283 482 dbSNP
rs915218589 483 dbSNP
rs1057043316 485 dbSNP
rs939527537 488 dbSNP
rs560230843 494 dbSNP
rs763483803 496 dbSNP
rs926741490 500 dbSNP
rs1360046183 504 dbSNP
rs1245029824 505 dbSNP
rs954235803 510 dbSNP
rs1045137441 513 dbSNP
rs1194604113 514 dbSNP
rs1215994128 517 dbSNP
rs4303488 521 dbSNP
rs574694922 529 dbSNP
rs1484578537 533 dbSNP
rs1183073597 539 dbSNP
rs566924098 540 dbSNP
rs544518730 541 dbSNP
rs551977502 544 dbSNP
rs952373589 545 dbSNP
rs1026619764 546 dbSNP
rs576797824 547 dbSNP
rs1450361572 548 dbSNP
rs1303473118 556 dbSNP
rs1012675891 561 dbSNP
rs894214798 567 dbSNP
rs1033884945 573 dbSNP
rs1355505620 575 dbSNP
rs924541467 576 dbSNP
rs1314732294 577 dbSNP
rs1211701528 588 dbSNP
rs1004104612 593 dbSNP
rs906806178 595 dbSNP
rs1461271592 597 dbSNP
rs1042634446 602 dbSNP
rs976358552 603 dbSNP
rs538703240 606 dbSNP
rs372465933 607 dbSNP
rs1470690887 613 dbSNP
rs747854261 616 dbSNP
rs558664616 619 dbSNP
rs1416381368 624 dbSNP
rs1007330703 632 dbSNP
rs951754326 633 dbSNP
rs111460702 638 dbSNP
rs993131763 640 dbSNP
rs1296191041 641 dbSNP
rs1370797952 643 dbSNP
rs898105995 647 dbSNP
rs1263221128 650 dbSNP
rs1143465 655 dbSNP
rs1056715005 656 dbSNP
rs1260603429 670 dbSNP
rs1292819320 679 dbSNP
rs187056414 680 dbSNP
rs1425778378 684 dbSNP
rs79620950 685 dbSNP
rs1171663152 688 dbSNP
rs757449758 690 dbSNP
rs112214019 697 dbSNP
rs1172866115 697 dbSNP
rs532219334 697 dbSNP
rs908348727 697 dbSNP
rs1327948974 699 dbSNP
rs1421748948 706 dbSNP
rs905348090 706 dbSNP
rs1283468252 707 dbSNP
rs780870864 719 dbSNP
rs1221199396 721 dbSNP
rs533650184 722 dbSNP
rs555050061 725 dbSNP
rs535606626 726 dbSNP
rs1271330818 728 dbSNP
rs1453646957 735 dbSNP
rs1052419117 736 dbSNP
rs571747274 738 dbSNP
rs866095384 741 dbSNP
rs952570696 742 dbSNP
rs1267308868 744 dbSNP
rs1479575542 750 dbSNP
rs1026691955 754 dbSNP
rs77395247 758 dbSNP
rs550075370 760 dbSNP
rs1394093266 761 dbSNP
rs958508807 763 dbSNP
rs1303504913 766 dbSNP
rs1364651729 767 dbSNP
rs976011063 770 dbSNP
rs1402709339 771 dbSNP
rs146547231 779 dbSNP
rs1326435616 782 dbSNP
rs1002600875 789 dbSNP
rs906723303 791 dbSNP
rs1362178944 793 dbSNP
rs1247254062 796 dbSNP
rs779373392 800 dbSNP
rs115535007 805 dbSNP
rs764435981 806 dbSNP
rs866675549 812 dbSNP
rs866293105 814 dbSNP
rs758338454 821 dbSNP
rs1053745059 828 dbSNP
rs750357957 830 dbSNP
rs932626617 832 dbSNP
rs961718308 833 dbSNP
rs1384320929 847 dbSNP
rs1422366290 851 dbSNP
rs899808586 854 dbSNP
rs1385082268 860 dbSNP
rs142848786 861 dbSNP
rs944104612 866 dbSNP
rs1398433516 867 dbSNP
rs1453935007 868 dbSNP
rs757013709 880 dbSNP
rs905402924 885 dbSNP
rs1357685779 900 dbSNP
rs1023766599 906 dbSNP
rs753536113 908 dbSNP
rs1466880707 909 dbSNP
rs1258338532 911 dbSNP
rs767802124 914 dbSNP
rs1377368299 917 dbSNP
rs1197183747 922 dbSNP
rs1242334945 923 dbSNP
rs527327176 925 dbSNP
rs1442163229 928 dbSNP
rs1239293409 932 dbSNP
rs1452588637 933 dbSNP
rs1156318851 935 dbSNP
rs1178770952 937 dbSNP
rs919826804 943 dbSNP
rs1336589186 946 dbSNP
rs755095313 953 dbSNP
rs1456896003 958 dbSNP
rs1270482247 962 dbSNP
rs1201749805 964 dbSNP
rs183307190 965 dbSNP
rs190389814 969 dbSNP
rs1265088969 974 dbSNP
rs1230787799 975 dbSNP
rs958631161 978 dbSNP
rs1204249401 980 dbSNP
rs1035331989 981 dbSNP
rs1309859689 983 dbSNP
rs981606548 984 dbSNP
rs867291007 998 dbSNP
rs1041421733 1003 dbSNP
rs1021117681 1006 dbSNP
rs1179176135 1011 dbSNP
rs1374675592 1012 dbSNP
rs61742599 1019 dbSNP
rs1480504623 1023 dbSNP
rs1175044085 1025 dbSNP
rs562764341 1026 dbSNP
rs1415317075 1033 dbSNP
rs958306699 1034 dbSNP
rs1299116844 1036 dbSNP
rs910429405 1044 dbSNP
rs1033027247 1047 dbSNP
rs544430682 1048 dbSNP
rs1389921073 1057 dbSNP
rs1285377144 1061 dbSNP
rs866856165 1065 dbSNP
rs930461032 1070 dbSNP
rs1381502169 1080 dbSNP
rs200949981 1084 dbSNP
rs1041013365 1092 dbSNP
rs971795470 1093 dbSNP
rs962072030 1094 dbSNP
rs1438542345 1096 dbSNP
rs1008769538 1097 dbSNP
rs1480157145 1101 dbSNP
rs1202728752 1102 dbSNP
rs1034693933 1107 dbSNP
rs1442710922 1109 dbSNP
rs577459145 1110 dbSNP
rs1198139319 1112 dbSNP
rs1208522215 1124 dbSNP
rs969700762 1125 dbSNP
rs1023838804 1131 dbSNP
rs1046958402 1132 dbSNP
rs565618718 1133 dbSNP
rs540217420 1137 dbSNP
rs893961141 1146 dbSNP
rs760957469 1160 dbSNP
rs573201225 1161 dbSNP
rs1366505578 1164 dbSNP
rs1056127739 1166 dbSNP
rs1301374035 1173 dbSNP
rs937239601 1175 dbSNP
rs1216274859 1184 dbSNP
rs901216331 1187 dbSNP
rs1306815566 1195 dbSNP
rs1448815245 1198 dbSNP
rs1041061274 1216 dbSNP
rs145777229 1217 dbSNP
rs61741215 1224 dbSNP
rs1402279482 1228 dbSNP
rs765739738 1230 dbSNP
rs1298133770 1233 dbSNP
rs1244508272 1234 dbSNP
rs1486535746 1238 dbSNP
rs575840053 1247 dbSNP
rs1261695150 1250 dbSNP
rs1418466035 1254 dbSNP
rs762304624 1259 dbSNP
rs368555620 1261 dbSNP
rs535135625 1267 dbSNP
rs556381225 1268 dbSNP
rs1424294750 1275 dbSNP
rs538075969 1278 dbSNP
rs1347161129 1285 dbSNP
rs920439609 1294 dbSNP
rs989836039 1305 dbSNP
rs958213745 1308 dbSNP
rs1164534647 1311 dbSNP
rs776812560 1315 dbSNP
rs745847360 1322 dbSNP
rs971851102 1323 dbSNP
rs1432740600 1324 dbSNP
rs1316900093 1331 dbSNP
rs1472827916 1332 dbSNP
rs1359840066 1335 dbSNP
rs1367552127 1337 dbSNP
rs940458088 1342 dbSNP
rs927695463 1346 dbSNP
rs1287364829 1351 dbSNP
rs981839610 1353 dbSNP
rs768368694 1354 dbSNP
rs1263708950 1358 dbSNP
rs1463935817 1359 dbSNP
rs1215622645 1361 dbSNP
rs1180448013 1365 dbSNP
rs1445252119 1384 dbSNP
rs1410521834 1387 dbSNP
rs181075880 1399 dbSNP
rs773335569 1401 dbSNP
rs1455604904 1402 dbSNP
rs1020068910 1412 dbSNP
rs1282212108 1414 dbSNP
rs1451705186 1414 dbSNP
rs1291670890 1417 dbSNP
rs149927444 1420 dbSNP
rs1223927012 1421 dbSNP
rs887212393 1426 dbSNP
rs1047196125 1431 dbSNP
rs1204988642 1435 dbSNP
rs1341341860 1446 dbSNP
rs1298040511 1452 dbSNP
rs1429022348 1474 dbSNP
rs533511269 1483 dbSNP
rs567829254 1485 dbSNP
rs1000069914 1493 dbSNP
rs1324726859 1497 dbSNP
rs1405474985 1498 dbSNP
rs1055593023 1499 dbSNP
rs1389318381 1504 dbSNP
rs937294076 1520 dbSNP
rs928560983 1522 dbSNP
rs566477138 1523 dbSNP
rs965527515 1531 dbSNP
rs547852782 1543 dbSNP
rs1406828384 1547 dbSNP
rs1413829998 1559 dbSNP
rs1331969189 1560 dbSNP
rs1356018362 1561 dbSNP
rs1442510501 1565 dbSNP
rs1248418469 1567 dbSNP
rs1222133289 1568 dbSNP
rs1348202148 1574 dbSNP
rs1224889214 1576 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions Flp-In T-REx 293-hAGO1 cells
Location of target site 3'UTR
Original Description (Extracted from the article) ... Validation of interactions identified by CLASH suppports their reliability. ...

- Helwak A; Kudla G; Dudnakova T; Tollervey D, 2013, Cell.

Article - Helwak A; Kudla G; Dudnakova T; Tollervey D
- Cell, 2013
MicroRNAs (miRNAs) play key roles in gene regulation, but reliable bioinformatic or experimental identification of their targets remains difficult. To provide an unbiased view of human miRNA targets, we developed a technique for ligation and sequencing of miRNA-target RNA duplexes associated with human AGO1. Here, we report data sets of more than 18,000 high-confidence miRNA-mRNA interactions. The binding of most miRNAs includes the 5' seed region, but around 60% of seed interactions are noncanonical, containing bulged or mismatched nucleotides. Moreover, seed interactions are generally accompanied by specific, nonseed base pairing. 18% of miRNA-mRNA interactions involve the miRNA 3' end, with little evidence for 5' contacts, and some of these were functionally validated. Analyses of miRNA:mRNA base pairing showed that miRNA species systematically differ in their target RNA interactions, and strongly overrepresented motifs were found in the interaction sites of several miRNAs. We speculate that these affect the response of RISC to miRNA-target binding.
LinkOut: [PMID: 23622248]
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
HNSC -0.415 0.01 -0.337 0.04 28 Click to see details
STAD 0.389 0.03 0.425 0.02 24 Click to see details
BRCA 0.216 0.04 0.125 0.16 65 Click to see details
BLCA 0.39 0.08 0.240 0.2 14 Click to see details
COAD 0.719 0.09 0.700 0.09 5 Click to see details
UCEC -0.37 0.09 -0.286 0.15 15 Click to see details
LIHC -0.181 0.12 -0.210 0.09 43 Click to see details
KIRC -0.13 0.18 -0.161 0.13 51 Click to see details
KIRP -0.175 0.19 -0.141 0.24 28 Click to see details
PAAD -0.582 0.21 -1.000 0.5 4 Click to see details
CHOL 0.303 0.25 0.321 0.24 7 Click to see details
LUSC -0.119 0.27 -0.183 0.17 29 Click to see details
PRAD 0.058 0.34 -0.035 0.4 50 Click to see details
ESCA 0.236 0.35 0.600 0.14 5 Click to see details
LUAD 0.127 0.35 0.109 0.37 11 Click to see details
KICH 0.068 0.37 0.058 0.39 25 Click to see details
THCA 0.011 0.47 0.059 0.34 49 Click to see details
THCA 0.011 0.47 0.059 0.34 49 Click to see details
THCA 0.011 0.47 0.059 0.34 49 Click to see details
THCA 0.011 0.47 0.059 0.34 49 Click to see details
THCA 0.011 0.47 0.059 0.34 49 Click to see details
101 hsa-miR-504-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT000044 DRD1 dopamine receptor D1 2 1
MIRT004457 VEGFA vascular endothelial growth factor A 2 1
MIRT016249 BAX BCL2 associated X, apoptosis regulator 1 1
MIRT016251 GADD45A growth arrest and DNA damage inducible alpha 1 1
MIRT016252 FAS Fas cell surface death receptor 1 1
MIRT016253 BBC3 BCL2 binding component 3 1 1
MIRT016254 TP53I3 tumor protein p53 inducible protein 3 1 1
MIRT016255 TCEAL1 transcription elongation factor A like 1 2 1
MIRT016256 MDM2 MDM2 proto-oncogene 2 1
MIRT016257 TP53 tumor protein p53 3 1
MIRT041072 P2RY13 purinergic receptor P2Y13 1 1
MIRT041073 PPIL1 peptidylprolyl isomerase like 1 1 1
MIRT041074 ZNF814 zinc finger protein 814 1 1
MIRT041075 HIST1H2AC histone cluster 1 H2A family member c 1 1
MIRT041076 FEM1A fem-1 homolog A 1 1
MIRT041077 TXNRD1 thioredoxin reductase 1 1 1
MIRT041078 RAI1 retinoic acid induced 1 1 1
MIRT041079 SRRM2 serine/arginine repetitive matrix 2 1 1
MIRT041080 HNRNPAB heterogeneous nuclear ribonucleoprotein A/B 1 1
MIRT041081 PDLIM1 PDZ and LIM domain 1 1 1
MIRT041082 FAM208B family with sequence similarity 208 member B 1 1
MIRT041083 PSAT1 phosphoserine aminotransferase 1 1 1
MIRT041084 TMEM8A transmembrane protein 8A 1 1
MIRT041085 RABGAP1 RAB GTPase activating protein 1 1 1
MIRT041086 BRD2 bromodomain containing 2 1 1
MIRT041087 C11orf58 chromosome 11 open reading frame 58 1 1
MIRT041088 CNOT8 CCR4-NOT transcription complex subunit 8 1 1
MIRT041089 RPL10 ribosomal protein L10 1 1
MIRT041090 SMCR7L mitochondrial elongation factor 1 1 1
MIRT041091 CENPBD1 CENPB DNA-binding domain containing 1 1 1
MIRT041092 SF3B1 splicing factor 3b subunit 1 1 1
MIRT041093 MTFP1 mitochondrial fission process 1 1 1
MIRT438313 CDK6 cyclin dependent kinase 6 1 1
MIRT438352 TFF1 trefoil factor 1 3 1
MIRT443009 KBTBD12 kelch repeat and BTB domain containing 12 2 2
MIRT448052 SFRP1 secreted frizzled related protein 1 2 2
MIRT457649 ZNF69 zinc finger protein 69 2 2
MIRT458626 TRIM72 tripartite motif containing 72 2 2
MIRT466176 TMED5 transmembrane p24 trafficking protein 5 2 2
MIRT472583 NACC1 nucleus accumbens associated 1 2 2
MIRT473576 MAT2A methionine adenosyltransferase 2A 2 6
MIRT485155 RASL10B RAS like family 10 member B 2 2
MIRT490063 PRRT2 proline rich transmembrane protein 2 2 2
MIRT493015 NANOS1 nanos C2HC-type zinc finger 1 2 2
MIRT499425 PLCG2 phospholipase C gamma 2 2 11
MIRT506956 HOXB3 homeobox B3 2 4
MIRT507100 GPCPD1 glycerophosphocholine phosphodiesterase 1 2 2
MIRT508101 ANKRD33B ankyrin repeat domain 33B 2 4
MIRT522215 NR2C2 nuclear receptor subfamily 2 group C member 2 2 6
MIRT530327 TNFRSF10D TNF receptor superfamily member 10d 2 2
MIRT531042 ZNF502 zinc finger protein 502 2 2
MIRT532580 GSS glutathione synthetase 2 2
MIRT534841 RAB15 RAB15, member RAS oncogene family 2 2
MIRT536820 HMGN2 high mobility group nucleosomal binding domain 2 2 2
MIRT538303 CSNK2A1 casein kinase 2 alpha 1 2 2
MIRT546344 TFAP2C transcription factor AP-2 gamma 2 2
MIRT546704 RORA RAR related orphan receptor A 2 4
MIRT549222 BCL2L11 BCL2 like 11 2 4
MIRT549623 TMEM101 transmembrane protein 101 2 2
MIRT549931 NDUFB5 NADH:ubiquinone oxidoreductase subunit B5 2 2
MIRT550163 ZNF223 zinc finger protein 223 2 4
MIRT550555 ARSK arylsulfatase family member K 2 2
MIRT553402 TRIM2 tripartite motif containing 2 2 4
MIRT554084 SNX4 sorting nexin 4 2 4
MIRT556962 IER3IP1 immediate early response 3 interacting protein 1 2 2
MIRT558525 CSRNP3 cysteine and serine rich nuclear protein 3 2 2
MIRT558565 CRLF3 cytokine receptor like factor 3 2 4
MIRT560946 TPM4 tropomyosin 4 2 4
MIRT561628 SERBP1 SERPINE1 mRNA binding protein 1 2 2
MIRT562174 HOXA13 homeobox A13 2 2
MIRT568635 ACVR2A activin A receptor type 2A 2 2
MIRT574908 Plcg2 phospholipase C, gamma 2 2 7
MIRT575177 Atg9a autophagy related 9A 2 2
MIRT611972 PKD1 polycystin 1, transient receptor potential channel interacting 2 2
MIRT613623 CLASP1 cytoplasmic linker associated protein 1 2 4
MIRT635830 OPA3 OPA3, outer mitochondrial membrane lipid metabolism regulator 2 4
MIRT637344 DARS2 aspartyl-tRNA synthetase 2, mitochondrial 2 4
MIRT643205 JAK3 Janus kinase 3 2 2
MIRT650232 SIGLEC9 sialic acid binding Ig like lectin 9 2 2
MIRT655940 NDUFA4P1 NDUFA4, mitochondrial complex associated pseudogene 1 2 2
MIRT662021 ZNF445 zinc finger protein 445 2 2
MIRT662037 FUT2 fucosyltransferase 2 2 2
MIRT666873 POU2F2 POU class 2 homeobox 2 2 2
MIRT684310 TRUB2 TruB pseudouridine synthase family member 2 2 2
MIRT687333 OSMR oncostatin M receptor 2 2
MIRT689008 ATP6AP1 ATPase H+ transporting accessory protein 1 2 2
MIRT695137 PRY2 PTPN13-like, Y-linked 2 2 2
MIRT695154 PRY PTPN13-like, Y-linked 2 2
MIRT700695 POLR3D RNA polymerase III subunit D 2 2
MIRT703269 GNL3L G protein nucleolar 3 like 2 2
MIRT708941 CRY2 cryptochrome circadian clock 2 2 2
MIRT709200 SAPCD2 suppressor APC domain containing 2 2 2
MIRT709572 PDE4A phosphodiesterase 4A 2 2
MIRT711295 PSME3 proteasome activator subunit 3 2 2
MIRT712425 MACROD2 MACRO domain containing 2 2 2
MIRT713941 PIGR polymeric immunoglobulin receptor 2 2
MIRT714124 TMED9 transmembrane p24 trafficking protein 9 2 2
MIRT714630 KIAA1143 KIAA1143 2 2
MIRT724046 SMIM14 small integral membrane protein 14 2 2
MIRT724649 PKDREJ polycystin family receptor for egg jelly 2 2
MIRT725476 GRAP2 GRB2-related adaptor protein 2 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-504 Emodin NULL 3220 Microarray K562 cells 23744534 2013 down-regualted
miR-504 Mistletoe lectin-I NULL NULL Microarray colorectal cancer cells CLY cells 20955366 2011 down-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-504 Ceritinib 57379345 NSC776422 approved sensitive High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-mir-504 Androstenedione+Anastrozole resistant cell line (MCF-7)
hsa-mir-504 Ceritinib 57379345 NSC776422 approved sensitive cell line (H3122)
hsa-miR-504-5p Oxaliplatin 6857599 NSC266046 approved resistant High Colorectal Cancer cell line (HT-29)
hsa-miR-504-5p Oxaliplatin 6857599 NSC266046 approved sensitive High Colorectal Cancer cell line (RKO)
hsa-miR-504-5p Plx-4720 24180719 NSC757438 sensitive High Thyroid Cancer cell line (8505c, BCPAP)
hsa-miR-504-5p Vemurafenib 42611257 NSC761431 approved sensitive High Melanoma cell line (A375, IGR37, 501Mel)
hsa-miR-504-5p Dabrafenib 44462760 NSC764134 approved sensitive High Melanoma cell line (A375, IGR37, 501Mel)
hsa-miR-504-5p Dabrafenib 44462760 NSC764134 approved resistant High Melanoma cell line (A375, IGR37, 501Mel)
hsa-miR-504-5p Vemurafenib 42611257 NSC761431 approved resistant High Melanoma cell line (A375, IGR37, 501Mel)
hsa-miR-504-5p Ceritinib 57379345 NSC776422 approved sensitive High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-miR-504-5p Fulvestrant 17756771 NSC719276 approved sensitive High Breast Cancer cell line (MCF-7, MCF-7-TT)
hsa-miR-504-5p Gefitinib 123631 NSC715055 approved resistant cell line (PC9)
hsa-miR-504-5p Osimertinib 71496458 NSC779217 approved resistant cell line (PC9)
hsa-miR-504-5p Vemurafenib 42611257 NSC761431 approved resistant cell line (A375)
hsa-miR-504-5p Vemurafenib 42611257 NSC761431 approved sensitive cell line (451Lu)
hsa-miR-504-5p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-504-5p Vemurafenib 42611257 NSC761431 approved resistant cell line (LM47)
hsa-miR-504-5p Vemurafenib 42611257 NSC761431 approved sensitive cell line (LM16)
hsa-miR-504-5p Vemurafenib 42611257 NSC761431 approved resistant cell line (LM17)
hsa-miR-504-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (CIS)
hsa-miR-504-5p Cisplatin 5460033 NSC119875 approved resistant cell line (MGC-803)
hsa-miR-504-5p Ethanol+Tamoxifen sensitive cell line (LY2)
hsa-miR-504-5p Sunitinib 5329102 NSC750690 approved resistant tissue (CardA)
hsa-miR-504-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-504-5p Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (1500 ng/ml)
hsa-miR-504-5p Ceritinib 57379345 NSC776422 approved sensitive cell line (H3122)
hsa-miR-504-5p Cisplatin 5460033 NSC119875 approved resistant cell line (H460)

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