miRTarBase - #MIRT046565


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pre-miRNA Information
pre-miRNA hsa-let-7g   
Genomic Coordinates chr3: 52268278 - 52268361
Synonyms LET7G, MIRNLET7G, hsa-let-7g, MIRLET7G
Description Homo sapiens let-7g stem-loop
Comment let-7g-3p cloned in has a 1 nt 3' extension (U), which is incompatible with the genome sequence.
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-let-7g-5p
Sequence 5| UGAGGUAGUAGUUUGUACAGUU |26
Evidence Experimental
Experiments Cloned
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 7 3 - 52268351 18684997 MiREDiBase
A-to-I 10 3 - 52268348 18684997, 29950133, 29233923 MiREDiBase
A-to-I 17 3 - 52268341 29233923 MiREDiBase
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSN1278471 5 COSMIC
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol RRM2   
Synonyms R2, RR2, RR2M
Description ribonucleotide reductase regulatory subunit M2
Transcript NM_001034   
Other Transcripts NM_001165931   
Expression
Putative miRNA Targets on RRM2
3'UTR of RRM2
(miRNA target sites are highlighted)		 
>RRM2|NM_001034|3'UTR
   1 ATGAACTGAAGATGTGCCCTTACTTGGCTGATTTTTTTTTTCCATCTCATAAGAAAAATCAGCTGAAGTGTTACCAACTA
  81 GCCACACCATGAATTGTCCGTAATGTTCATTAACAGCATCTTTAAAACTGTGTAGCTACCTCACAACCAGTCCTGTCTGT
 161 TTATAGTGCTGGTAGTATCACCTTTTGCCAGAAGGCCTGGCTGGCTGTGACTTACCATAGCAGTGACAATGGCAGTCTTG
 241 GCTTTAAAGTGAGGGGTGACCCTTTAGTGAGCTTAGCACAGCGGGATTAAACAGTCCTTTAACCAGCACAGCCAGTTAAA
 321 AGATGCAGCCTCACTGCTTCAACGCAGATTTTAATGTTTACTTAAATATAAACCTGGCACTTTACAAACAAATAAACATT
 401 GTTTGTACTCACAAGGCGATAATAGCTTGATTTATTTGGTTTCTACACCAAATACATTCTCCTGACCACTAATGGGAGCC
 481 AATTCACAATTCACTAAGTGACTAAAGTAAGTTAAACTTGTGTAGACTAAGCATGTAATTTTTAAGTTTTATTTTAATGA
 561 ATTAAAATATTTGTTAACCAACTTTAAAGTCAGTCCTGTGTATACCTAGATATTAGTCAGTTGGTGCCAGATAGAAGACA
 641 GGTTGTGTTTTTATCCTGTGGCTTGTGTAGTGTCCTGGGATTCTCTGCCCCCTCTGAGTAGAGTGTTGTGGGATAAAGGA
 721 ATCTCTCAGGGCAAGGAGCTTCTTAAGTTAAATCACTAGAAATTTAGGGGTGATCTGGGCCTTCATATGTGTGAGAAGCC
 801 GTTTCATTTTATTTCTCACTGTATTTTCCTCAACGTCTGGTTGATGAGAAAAAATTCTTGAAGAGTTTTCATATGTGGGA
 881 GCTAAGGTAGTATTGTAAAATTTCAAGTCATCCTTAAACAAAATGATCCACCTAAGATCTTGCCCCTGTTAAGTGGTGAA
 961 ATCAACTAGAGGTGGTTCCTACAAGTTGTTCATTCTAGTTTTGTTTGGTGTAAGTAGGTTGTGTGAGTTAATTCATTTAT
1041 ATTTACTATGTCTGTTAAATCAGAAATTTTTTATTATCTATGTTCTTCTAGATTTTACCTGTAGTTCATACTTCAGTCAC
1121 CCAGTGTCTTATTCTGGCATTGTCTAAATCTGAGCATTGTCTAGGGGGATCTTAAACTTTAGTAGGAAACCATGAGCTGT
1201 TAATACAGTTTCCATTCAAATATTAATTTCAGAATGAAACATAATTTTTTTTTTTTTTTTTGAGATGGAGTCTCGCTCTG
1281 TTGCCCAGGCTGGAGTGCAGTGGCGCGATTTTGGCTCACTGTAACCTCCATCTCCTGGGTTCAAGCAATTCTCCTGTCTC
1361 AGCCTCCCTAGTAGCTGGGACTGCAGGTATGTGCTACCACACCTGGCTAATTTTTGTATTTTTAGTAGAGATGGAGTTTC
1441 ACCATATTGGTCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCCACCCACCTCGGCCTCCCAAAGTGCTGGGATTGCA
1521 GGCGTGATAAACAAATATTCTTAATAGGGCTACTTTGAATTAATCTGCCTTTATGTTTGGGAGAAGAAAGCTGAGACATT
1601 GCATGAAAGATGATGAGAGATAAATGTTGATCTTTTGGCCCCATTTGTTAATTGTATTCAGTATTTGAACGTCGTCCTGT
1681 TTATTGTTAGTTTTCTTCATCATTTATTGTATAGACAATTTTTAAATCTCTGTAATATGATACATTTTCCTATCTTTTAA
1761 GTTATTGTTACCTAAAGTTAATCCAGATTATATGGTCCTTATATGTGTACAACATTAAAATGAAAGGCTTTGTCTTGCAT
1841 TGTGAGGTACAGGCGGAAGTTGGAATCAGGTTTTAGGATTCTGTCTCTCATTAGCTGAATAATGTGAGGATTAACTTCTG
1921 CCAGCTCAGACCATTTCCTAATCAGTTGAAAGGGAAACAAGTATTTCAGTCTCAAAATTGAATAATGCACAAGTCTTAAG
2001 TGATTAAAATAAAACTGTTCTTATGTCAGTTTCAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' uuGACAUGUUUGA-----UGAUGGAGu 5'
            || || |||||     :||||||| 
Target 5' atCTTTA-AAACTGTGTAGCTACCTCa 3'
 118 - 143 159.00 -20.10
2 
miRNA  3' uuGACAUG--UUUGAUGA-UGGAGu 5'
            |||  |  :|||| || ||||| 
Target 5' ggCTGGTCTTGAACTCCTGACCTCa 3'
 1454 - 1478 130.00 -15.10
3 
miRNA  3' uugacAUGUUUGA-UGAUGGAGu 5'
               |:||: || |||:|:|| 
Target 5' aaagaTGCAGCCTCACTGCTTCa 3'
 319 - 341 129.00 -14.60
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN31485740 28 COSMIC
COSN1220591 42 COSMIC
COSN31613776 42 COSMIC
COSN30153780 49 COSMIC
COSN30518760 49 COSMIC
COSN31576965 51 COSMIC
COSN19312988 83 COSMIC
COSN31543880 101 COSMIC
COSN31583080 117 COSMIC
COSN28750194 135 COSMIC
COSN26677306 160 COSMIC
COSN19660334 181 COSMIC
COSN30120258 197 COSMIC
COSN31523393 299 COSMIC
COSN29192619 322 COSMIC
COSN6149472 348 COSMIC
COSN31488910 444 COSMIC
COSN29549608 451 COSMIC
COSN24013993 695 COSMIC
COSN30031157 786 COSMIC
COSN20096319 1262 COSMIC
COSN21407161 1359 COSMIC
COSN4909415 1519 COSMIC
COSN17376957 1675 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs756637379 2 dbSNP
rs778037879 11 dbSNP
rs749647333 16 dbSNP
rs771373014 17 dbSNP
rs376458388 22 dbSNP
rs371603045 32 dbSNP
rs764059345 32 dbSNP
rs78311808 32 dbSNP
rs756710024 33 dbSNP
rs79162203 33 dbSNP
rs1258460287 35 dbSNP
rs5030757 36 dbSNP
rs1247301601 38 dbSNP
rs1186886752 42 dbSNP
rs772288724 45 dbSNP
rs567302711 50 dbSNP
rs975301006 74 dbSNP
rs535862183 79 dbSNP
rs923485611 83 dbSNP
rs1469556842 86 dbSNP
rs1407301205 89 dbSNP
rs1179201192 94 dbSNP
rs186654277 100 dbSNP
rs151112936 101 dbSNP
rs1191897819 119 dbSNP
rs776799796 129 dbSNP
rs1263346898 131 dbSNP
rs1181385288 139 dbSNP
rs1460656066 140 dbSNP
rs538123832 147 dbSNP
rs978160437 156 dbSNP
rs1337429404 166 dbSNP
rs557947933 173 dbSNP
rs1250803716 178 dbSNP
rs577803252 191 dbSNP
rs1337026883 196 dbSNP
rs1358250641 198 dbSNP
rs1313101479 200 dbSNP
rs1445289424 202 dbSNP
rs1452269056 210 dbSNP
rs534347219 216 dbSNP
rs1383971126 226 dbSNP
rs1339160724 234 dbSNP
rs774957221 239 dbSNP
rs1390135279 244 dbSNP
rs1396354023 251 dbSNP
rs1291010685 256 dbSNP
rs1462000907 267 dbSNP
rs1363006245 270 dbSNP
rs5030759 273 dbSNP
rs1276845424 278 dbSNP
rs1325818883 279 dbSNP
rs1224170599 281 dbSNP
rs1277958451 283 dbSNP
rs1189412402 284 dbSNP
rs1310689264 286 dbSNP
rs936676506 288 dbSNP
rs191054082 306 dbSNP
rs914462632 307 dbSNP
rs1243639203 310 dbSNP
rs574906421 315 dbSNP
rs1341551311 324 dbSNP
rs139954791 344 dbSNP
rs79765591 354 dbSNP
rs1260893939 357 dbSNP
rs948688925 359 dbSNP
rs1317465871 367 dbSNP
rs1044599335 369 dbSNP
rs1335560801 384 dbSNP
rs1330065900 386 dbSNP
rs1393716129 388 dbSNP
rs1293078218 390 dbSNP
rs1423781056 394 dbSNP
rs534766369 398 dbSNP
rs1412401959 399 dbSNP
rs1047516544 409 dbSNP
rs545306582 410 dbSNP
rs1164662966 411 dbSNP
rs1468346086 417 dbSNP
rs1160832307 418 dbSNP
rs886230373 425 dbSNP
rs1005880515 429 dbSNP
rs144948625 434 dbSNP
rs1266824581 438 dbSNP
rs185874295 440 dbSNP
rs1490540373 442 dbSNP
rs996458906 444 dbSNP
rs1296935277 454 dbSNP
rs1347974724 456 dbSNP
rs1203621237 459 dbSNP
rs1406036418 460 dbSNP
rs1350404867 463 dbSNP
rs1280566860 467 dbSNP
rs1274351714 470 dbSNP
rs1241783878 480 dbSNP
rs1344219650 485 dbSNP
rs1342880009 490 dbSNP
rs1403746254 495 dbSNP
rs1030887637 502 dbSNP
rs547511857 503 dbSNP
rs1398648410 506 dbSNP
rs1383937331 512 dbSNP
rs1225756566 518 dbSNP
rs1473468129 519 dbSNP
rs1427053162 521 dbSNP
rs1198617243 529 dbSNP
rs867120429 532 dbSNP
rs1248599398 536 dbSNP
rs764106357 539 dbSNP
rs1285189270 544 dbSNP
rs1446688886 567 dbSNP
rs769909116 570 dbSNP
rs62129883 582 dbSNP
rs1321884767 594 dbSNP
rs1215667504 597 dbSNP
rs1224730997 606 dbSNP
rs1283557335 615 dbSNP
rs1345578234 617 dbSNP
rs1490823017 624 dbSNP
rs1031041610 632 dbSNP
rs10178011 646 dbSNP
rs201630221 666 dbSNP
rs1318588616 668 dbSNP
rs1458564138 677 dbSNP
rs549536921 678 dbSNP
rs1403643218 679 dbSNP
rs943264042 681 dbSNP
rs989423360 688 dbSNP
rs916604481 692 dbSNP
rs569278922 698 dbSNP
rs1475146749 699 dbSNP
rs1178627643 700 dbSNP
rs948615515 710 dbSNP
rs753857774 722 dbSNP
rs538183732 724 dbSNP
rs1367784495 725 dbSNP
rs868538774 726 dbSNP
rs928421140 733 dbSNP
rs938494630 739 dbSNP
rs551639029 756 dbSNP
rs886174658 766 dbSNP
rs1338195360 769 dbSNP
rs1270345626 773 dbSNP
rs941782920 776 dbSNP
rs114571498 779 dbSNP
rs1335896650 784 dbSNP
rs1444426961 801 dbSNP
rs900179009 802 dbSNP
rs1168269247 816 dbSNP
rs1409395441 818 dbSNP
rs534137052 830 dbSNP
rs1030584011 835 dbSNP
rs554292811 836 dbSNP
rs1384965126 840 dbSNP
rs192510398 847 dbSNP
rs1184546204 849 dbSNP
rs1484455676 849 dbSNP
rs536716140 855 dbSNP
rs556628299 860 dbSNP
rs1306809175 862 dbSNP
rs183195414 869 dbSNP
rs1281803697 874 dbSNP
rs34279704 877 dbSNP
rs999636218 890 dbSNP
rs5030760 894 dbSNP
rs766063643 916 dbSNP
rs958091335 920 dbSNP
rs545368074 927 dbSNP
rs1356877981 932 dbSNP
rs558883655 953 dbSNP
rs1289036676 954 dbSNP
rs1449420205 957 dbSNP
rs989538564 966 dbSNP
rs1206052309 970 dbSNP
rs1024025574 976 dbSNP
rs969421525 980 dbSNP
rs1438710470 992 dbSNP
rs1309978425 996 dbSNP
rs186091130 1002 dbSNP
rs1176327484 1004 dbSNP
rs1345067162 1011 dbSNP
rs1387548261 1020 dbSNP
rs1384789112 1022 dbSNP
rs1473323766 1024 dbSNP
rs1163227912 1025 dbSNP
rs1425857127 1050 dbSNP
rs1389243321 1053 dbSNP
rs190501818 1054 dbSNP
rs1470827314 1059 dbSNP
rs115318989 1074 dbSNP
rs928564013 1077 dbSNP
rs182776618 1081 dbSNP
rs578112183 1083 dbSNP
rs983263669 1085 dbSNP
rs1384781580 1089 dbSNP
rs907724615 1091 dbSNP
rs1350986799 1094 dbSNP
rs941729931 1098 dbSNP
rs1403118820 1099 dbSNP
rs1294335161 1104 dbSNP
rs775895379 1108 dbSNP
rs763139689 1115 dbSNP
rs1459694456 1117 dbSNP
rs749562845 1118 dbSNP
rs1283344483 1119 dbSNP
rs557816054 1121 dbSNP
rs1158890795 1126 dbSNP
rs537779131 1127 dbSNP
rs1401684000 1149 dbSNP
rs1414774756 1151 dbSNP
rs1354195765 1155 dbSNP
rs921556741 1169 dbSNP
rs1216202657 1170 dbSNP
rs1191388237 1183 dbSNP
rs1489278811 1190 dbSNP
rs931662559 1195 dbSNP
rs1051900862 1196 dbSNP
rs529769226 1198 dbSNP
rs200259620 1200 dbSNP
rs1269866533 1205 dbSNP
rs1196438457 1224 dbSNP
rs188323526 1229 dbSNP
rs1221682177 1230 dbSNP
rs562974254 1237 dbSNP
rs1302129685 1239 dbSNP
rs1388711150 1242 dbSNP
rs999752248 1243 dbSNP
rs1174906670 1245 dbSNP
rs1469794405 1245 dbSNP
rs34217469 1245 dbSNP
rs397732775 1245 dbSNP
rs1052524331 1246 dbSNP
rs1176102799 1250 dbSNP
rs1367025328 1258 dbSNP
rs76515542 1262 dbSNP
rs1368812454 1263 dbSNP
rs1458661866 1264 dbSNP
rs531969479 1271 dbSNP
rs1010908271 1273 dbSNP
rs1322786699 1275 dbSNP
rs1256549645 1276 dbSNP
rs571350098 1279 dbSNP
rs537185523 1284 dbSNP
rs557670968 1286 dbSNP
rs192657663 1289 dbSNP
rs1403223403 1291 dbSNP
rs182957125 1305 dbSNP
rs547688813 1306 dbSNP
rs187569312 1307 dbSNP
rs1335186484 1308 dbSNP
rs1003534411 1320 dbSNP
rs1403469692 1337 dbSNP
rs1486764240 1337 dbSNP
rs1338415452 1340 dbSNP
rs1305122528 1346 dbSNP
rs1467069531 1349 dbSNP
rs1370907241 1351 dbSNP
rs1167556947 1358 dbSNP
rs191269083 1364 dbSNP
rs557271849 1370 dbSNP
rs1035453135 1371 dbSNP
rs1316814582 1382 dbSNP
rs1460724229 1384 dbSNP
rs959919500 1389 dbSNP
rs1202115023 1390 dbSNP
rs1479697743 1391 dbSNP
rs983377685 1399 dbSNP
rs907675195 1407 dbSNP
rs963209913 1408 dbSNP
rs1313212042 1410 dbSNP
rs1345294125 1412 dbSNP
rs1138727 1417 dbSNP
rs1138728 1419 dbSNP
rs1341447993 1424 dbSNP
rs1390224534 1443 dbSNP
rs556689737 1445 dbSNP
rs1254596658 1447 dbSNP
rs570106471 1455 dbSNP
rs1449083925 1457 dbSNP
rs1429865865 1459 dbSNP
rs1195093344 1464 dbSNP
rs868811318 1468 dbSNP
rs1472306690 1478 dbSNP
rs539045567 1481 dbSNP
rs768854661 1490 dbSNP
rs1378217749 1491 dbSNP
rs1205895334 1494 dbSNP
rs1465735805 1496 dbSNP
rs1171036798 1499 dbSNP
rs1222111205 1519 dbSNP
rs1051414332 1520 dbSNP
rs774481698 1524 dbSNP
rs1237478567 1525 dbSNP
rs1293717473 1529 dbSNP
rs1401596289 1529 dbSNP
rs558946103 1542 dbSNP
rs1298778537 1545 dbSNP
rs879227886 1553 dbSNP
rs11545188 1557 dbSNP
rs935551266 1565 dbSNP
rs761886364 1600 dbSNP
rs184927325 1602 dbSNP
rs1339783024 1604 dbSNP
rs1398004225 1606 dbSNP
rs1451380670 1610 dbSNP
rs1411061886 1615 dbSNP
rs1182814201 1618 dbSNP
rs1284645672 1622 dbSNP
rs1184549612 1640 dbSNP
rs572272890 1641 dbSNP
rs772140952 1655 dbSNP
rs1331170638 1661 dbSNP
rs1232150210 1664 dbSNP
rs541289255 1671 dbSNP
rs1350428304 1672 dbSNP
rs1045671115 1674 dbSNP
rs1261362418 1675 dbSNP
rs905256462 1677 dbSNP
rs1217845952 1681 dbSNP
rs1138729 1684 dbSNP
rs1331272143 1684 dbSNP
rs1325126799 1697 dbSNP
rs1034987931 1710 dbSNP
rs374044024 1716 dbSNP
rs766135373 1717 dbSNP
rs951366002 1718 dbSNP
rs1004763662 1723 dbSNP
rs1487602398 1724 dbSNP
rs1014846857 1727 dbSNP
rs963323051 1728 dbSNP
rs1268231251 1729 dbSNP
rs1464727146 1737 dbSNP
rs761753577 1739 dbSNP
rs1211106202 1746 dbSNP
rs1322089756 1750 dbSNP
rs1432660907 1752 dbSNP
rs1278582773 1753 dbSNP
rs1197090565 1755 dbSNP
rs1218065965 1762 dbSNP
rs1345112949 1772 dbSNP
rs574555188 1779 dbSNP
rs973247082 1784 dbSNP
rs1365727737 1785 dbSNP
rs543162257 1786 dbSNP
rs145863886 1794 dbSNP
rs1321022057 1795 dbSNP
rs987635024 1799 dbSNP
rs1403754242 1804 dbSNP
rs767414325 1809 dbSNP
rs1415046382 1812 dbSNP
rs1417853770 1819 dbSNP
rs1427440420 1829 dbSNP
rs1166359293 1833 dbSNP
rs960282805 1843 dbSNP
rs1449148410 1849 dbSNP
rs934997491 1850 dbSNP
rs1295204849 1855 dbSNP
rs542863601 1856 dbSNP
rs1237340246 1863 dbSNP
rs530846614 1878 dbSNP
rs1280186489 1884 dbSNP
rs1385701584 1884 dbSNP
rs915482402 1886 dbSNP
rs1340971504 1889 dbSNP
rs1020623988 1891 dbSNP
rs1230269719 1896 dbSNP
rs946985020 1904 dbSNP
rs1448743452 1910 dbSNP
rs1298505362 1916 dbSNP
rs966394469 1930 dbSNP
rs532030581 1932 dbSNP
rs1371350459 1933 dbSNP
rs905370078 1934 dbSNP
rs1443154108 1935 dbSNP
rs13389058 1952 dbSNP
rs758777026 1958 dbSNP
rs979573058 1964 dbSNP
rs1182924764 1974 dbSNP
rs939416165 1980 dbSNP
rs1231704031 1984 dbSNP
rs1202345480 1991 dbSNP
rs1482450347 2005 dbSNP
rs1274841412 2012 dbSNP
rs925074527 2021 dbSNP
rs1351957475 2023 dbSNP
rs145536953 2024 dbSNP
rs1225446784 2025 dbSNP
rs1288926804 2028 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Disease 6241.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM714645. RNA binding protein: AGO2. Condition:completeT1 ...

- Kishore S; Jaskiewicz L; Burger L; Hausser et al., 2011, Nature methods.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' uugACAUGUUUGA-----UGAUGGAGu 5'
             | || |||||     :||||||| 
Target 5' ---UUUA-AAACUGUGUAGCUACCUCa 3'
 		1 - 23
Article - Kishore S; Jaskiewicz L; Burger L; Hausser et al.
- Nature methods, 2011
Cross-linking and immunoprecipitation (CLIP) is increasingly used to map transcriptome-wide binding sites of RNA-binding proteins. We developed a method for CLIP data analysis, and applied it to compare CLIP with photoactivatable ribonucleoside-enhanced CLIP (PAR-CLIP) and to uncover how differences in cross-linking and ribonuclease digestion affect the identified sites. We found only small differences in accuracies of these methods in identifying binding sites of HuR, which binds low-complexity sequences, and Argonaute 2, which has a complex binding specificity. We found that cross-link-induced mutations led to single-nucleotide resolution for both PAR-CLIP and CLIP. Our results confirm the expectation from original CLIP publications that RNA-binding proteins do not protect their binding sites sufficiently under the denaturing conditions used during the CLIP procedure, and we show that extensive digestion with sequence-specific RNases strongly biases the recovered binding sites. This bias can be substantially reduced by milder nuclease digestion conditions.
LinkOut: [PMID: 21572407]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions Flp-In T-REx 293-hAGO1 cells
Location of target site 3'UTR
Original Description (Extracted from the article) ... Validation of interactions identified by CLASH suppports their reliability. ...

- Helwak A; Kudla G; Dudnakova T; Tollervey D, 2013, Cell.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' uuGACAUGUUUGA-----UGAUGGAGu 5'
            || || |||||     :||||||| 
Target 5' -tCTTTA-AAACTGTGTAGCTACCTCa 3'
 		1 - 25
Article - Helwak A; Kudla G; Dudnakova T; Tollervey D
- Cell, 2013
MicroRNAs (miRNAs) play key roles in gene regulation, but reliable bioinformatic or experimental identification of their targets remains difficult. To provide an unbiased view of human miRNA targets, we developed a technique for ligation and sequencing of miRNA-target RNA duplexes associated with human AGO1. Here, we report data sets of more than 18,000 high-confidence miRNA-mRNA interactions. The binding of most miRNAs includes the 5' seed region, but around 60% of seed interactions are noncanonical, containing bulged or mismatched nucleotides. Moreover, seed interactions are generally accompanied by specific, nonseed base pairing. 18% of miRNA-mRNA interactions involve the miRNA 3' end, with little evidence for 5' contacts, and some of these were functionally validated. Analyses of miRNA:mRNA base pairing showed that miRNA species systematically differ in their target RNA interactions, and strongly overrepresented motifs were found in the interaction sites of several miRNAs. We speculate that these affect the response of RISC to miRNA-target binding.
LinkOut: [PMID: 23622248]
CLIP-seq Support 1 for dataset GSM714645
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / completeT1, repB
Location of target site ENST00000360566.2 | 3UTR | UUUAAAACUGUGUAGCUACCUCACAACCAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 21572407 / GSE28865
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
STAD 0.683 0 0.672 0 32 Click to see details
KIRC 0.277 0.01 0.313 0 68 Click to see details
CHOL -0.69 0.02 -0.617 0.04 9 Click to see details
KIRP -0.348 0.03 -0.162 0.19 32 Click to see details
LIHC -0.212 0.07 -0.215 0.07 49 Click to see details
PAAD 0.727 0.14 0.200 0.4 4 Click to see details
LUSC -0.148 0.19 -0.180 0.14 38 Click to see details
PCPG 0.818 0.2 0.500 0.33 3 Click to see details
UCEC -0.183 0.23 -0.218 0.18 19 Click to see details
BLCA 0.166 0.26 0.139 0.29 18 Click to see details
COAD -0.266 0.26 -0.333 0.21 8 Click to see details
THCA 0.082 0.27 0.034 0.4 59 Click to see details
PRAD 0.086 0.28 0.142 0.16 50 Click to see details
BRCA 0.064 0.28 0.071 0.26 84 Click to see details
CESC 0.622 0.29 0.500 0.33 3 Click to see details
KICH 0.095 0.33 0.153 0.23 25 Click to see details
HNSC -0.058 0.36 -0.061 0.35 42 Click to see details
ESCA 0.053 0.44 0.009 0.49 11 Click to see details
LUAD -0.026 0.47 -0.049 0.44 12 Click to see details
LUAD -0.026 0.47 -0.049 0.44 12 Click to see details
LUAD -0.026 0.47 -0.049 0.44 12 Click to see details
310 hsa-let-7g-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT000396 CDK6 cyclin dependent kinase 6 1 1
MIRT000397 CDC25A cell division cycle 25A 1 1
MIRT000399 KRAS KRAS proto-oncogene, GTPase 2 2
MIRT000472 COL1A2 collagen type I alpha 2 chain 4 1
MIRT000475 MYC MYC proto-oncogene, bHLH transcription factor 4 3
MIRT002097 HMGA2 high mobility group AT-hook 2 6 8
MIRT003831 IGF2BP1 insulin like growth factor 2 mRNA binding protein 1 6 4
MIRT004489 CDKN2A cyclin dependent kinase inhibitor 2A 4 1
MIRT004490 BCL2L1 BCL2 like 1 4 1
MIRT006161 GAB2 GRB2 associated binding protein 2 3 1
MIRT006162 FN1 fibronectin 1 3 1
MIRT006399 IL13 interleukin 13 2 1
MIRT024117 DAD1 defender against cell death 1 1 1
MIRT024118 EIF4G2 eukaryotic translation initiation factor 4 gamma 2 3 5
MIRT024119 TBC1D9 TBC1 domain family member 9 2 1
MIRT024120 BMI1 BMI1 proto-oncogene, polycomb ring finger 2 1
MIRT046555 DCAF8 DDB1 and CUL4 associated factor 8 1 1
MIRT046556 EEF1A1 eukaryotic translation elongation factor 1 alpha 1 1 1
MIRT046557 UBE3C ubiquitin protein ligase E3C 1 1
MIRT046558 RPL12 ribosomal protein L12 1 1
MIRT046559 SFT2D1 SFT2 domain containing 1 1 1
MIRT046560 MAP3K1 mitogen-activated protein kinase kinase kinase 1 1 1
MIRT046561 BRD1 bromodomain containing 1 1 1
MIRT046562 AGO1 argonaute 1, RISC catalytic component 4 2
MIRT046563 RAB21 RAB21, member RAS oncogene family 1 1
MIRT046564 HMGB1 high mobility group box 1 1 1
MIRT046565 RRM2 ribonucleotide reductase regulatory subunit M2 2 3
MIRT046566 AKAP11 A-kinase anchoring protein 11 1 1
MIRT046567 RANBP2 RAN binding protein 2 1 1
MIRT046568 SART3 squamous cell carcinoma antigen recognized by T-cells 3 1 1
MIRT054642 CASP3 caspase 3 2 1
MIRT054662 THBS1 thrombospondin 1 5 4
MIRT054663 TGFBR1 transforming growth factor beta receptor 1 3 1
MIRT054664 SMAD2 SMAD family member 2 3 1
MIRT063199 ADIPOR2 adiponectin receptor 2 2 2
MIRT065691 ESPL1 extra spindle pole bodies like 1, separase 2 4
MIRT067403 TMTC3 transmembrane and tetratricopeptide repeat containing 3 2 2
MIRT068157 TXLNA taxilin alpha 2 2
MIRT068532 NHLRC3 NHL repeat containing 3 2 6
MIRT068792 FNDC3A fibronectin type III domain containing 3A 2 2
MIRT073008 ARID3B AT-rich interaction domain 3B 2 6
MIRT073672 IGF1R insulin like growth factor 1 receptor 2 8
MIRT076227 SMCR8 Smith-Magenis syndrome chromosome region, candidate 8 2 6
MIRT080402 ONECUT2 one cut homeobox 2 2 2
MIRT083304 ZCCHC3 zinc finger CCHC-type containing 3 2 2
MIRT084979 BACH1 BTB domain and CNC homolog 1 2 2
MIRT094164 PCGF3 polycomb group ring finger 3 2 6
MIRT094464 SMARCAD1 SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1 2 4
MIRT095770 GRPEL2 GrpE like 2, mitochondrial 2 10
MIRT100096 ABT1 activator of basal transcription 1 2 8
MIRT112245 MDM4 MDM4, p53 regulator 2 4
MIRT118589 STK4 serine/threonine kinase 4 2 2
MIRT120924 PDE12 phosphodiesterase 12 2 8
MIRT123321 CALU calumenin 2 2
MIRT123980 POLR3D RNA polymerase III subunit D 2 2
MIRT152281 TNFSF9 TNF superfamily member 9 2 2
MIRT153856 NCOA3 nuclear receptor coactivator 3 2 2
MIRT168587 HMGA1 high mobility group AT-hook 1 2 4
MIRT180606 CRY2 cryptochrome circadian clock 2 2 2
MIRT187721 SUOX sulfite oxidase 2 2
MIRT191407 NAA30 N(alpha)-acetyltransferase 30, NatC catalytic subunit 2 2
MIRT193104 MAPK6 mitogen-activated protein kinase 6 2 2
MIRT215724 C5ORF51 chromosome 5 open reading frame 51 2 10
MIRT218816 CDKN1A cyclin dependent kinase inhibitor 1A 2 2
MIRT240333 UBXN2B UBX domain protein 2B 2 2
MIRT243476 TRIM71 tripartite motif containing 71 2 2
MIRT244074 EDN1 endothelin 1 2 2
MIRT252334 SALL3 spalt like transcription factor 3 2 2
MIRT255318 CDV3 CDV3 homolog 2 2
MIRT259280 PGRMC1 progesterone receptor membrane component 1 2 2
MIRT259483 TXLNG taxilin gamma 2 2
MIRT260711 CLDN12 claudin 12 2 6
MIRT264695 C11ORF57 chromosome 11 open reading frame 57 2 4
MIRT266216 PEX11B peroxisomal biogenesis factor 11 beta 2 2
MIRT266629 CHTOP chromatin target of PRMT1 2 2
MIRT268842 C1ORF21 chromosome 1 open reading frame 21 2 2
MIRT284531 PDP2 pyruvate dehyrogenase phosphatase catalytic subunit 2 2 2
MIRT294449 ZNF264 zinc finger protein 264 2 2
MIRT297445 SLC20A1 solute carrier family 20 member 1 2 4
MIRT300041 BZW1 basic leucine zipper and W2 domains 1 2 4
MIRT300896 KREMEN1 kringle containing transmembrane protein 1 2 2
MIRT303323 MXD1 MAX dimerization protein 1 2 2
MIRT309849 NAT8L N-acetyltransferase 8 like 2 2
MIRT322431 PPP2R2A protein phosphatase 2 regulatory subunit Balpha 2 2
MIRT324735 ACER2 alkaline ceramidase 2 2 2
MIRT402061 ATP6V1F ATPase H+ transporting V1 subunit F 2 4
MIRT437976 AKT2 AKT serine/threonine kinase 2 3 1
MIRT438631 TNFRSF10B TNF receptor superfamily member 10b 2 1
MIRT442018 NDUFA4P1 NDUFA4, mitochondrial complex associated pseudogene 1 2 2
MIRT445656 ATP6V1G1 ATPase H+ transporting V1 subunit G1 2 6
MIRT447134 KIF27 kinesin family member 27 2 2
MIRT448256 ZNF774 zinc finger protein 774 2 2
MIRT449009 ANKRD46 ankyrin repeat domain 46 2 2
MIRT449951 FMNL3 formin like 3 2 2
MIRT451153 C19orf53 chromosome 19 open reading frame 53 2 2
MIRT451622 MEIS3P1 Meis homeobox 3 pseudogene 1 2 2
MIRT451691 C1RL complement C1r subcomponent like 2 2
MIRT452090 NUCB2 nucleobindin 2 2 2
MIRT452429 QDPR quinoid dihydropteridine reductase 2 2
MIRT452941 DISC1 disrupted in schizophrenia 1 2 2
MIRT453399 RHD Rh blood group D antigen 2 6
MIRT454162 HIST1H2BK histone cluster 1 H2B family member k 2 2
MIRT454278 FXN frataxin 2 2
MIRT454537 RABL2A RAB, member of RAS oncogene family like 2A 2 2
MIRT454852 ACOT9 acyl-CoA thioesterase 9 2 4
MIRT455674 GLO1 glyoxalase I 2 2
MIRT457246 RABL2B RAB, member of RAS oncogene family like 2B 2 2
MIRT457675 ZNF587 zinc finger protein 587 2 2
MIRT457885 THEM6 thioesterase superfamily member 6 2 4
MIRT458014 MRPL12 mitochondrial ribosomal protein L12 2 2
MIRT458277 FUT10 fucosyltransferase 10 2 2
MIRT459734 RRM1 ribonucleotide reductase catalytic subunit M1 2 2
MIRT460451 NOM1 nucleolar protein with MIF4G domain 1 2 4
MIRT460498 FAM105A family with sequence similarity 105 member A 2 6
MIRT460936 NOA1 nitric oxide associated 1 2 4
MIRT461090 OPA3 OPA3, outer mitochondrial membrane lipid metabolism regulator 2 2
MIRT461167 SLC11A2 solute carrier family 11 member 2 2 4
MIRT461362 COL8A1 collagen type VIII alpha 1 chain 2 2
MIRT462380 YAE1D1 Yae1 domain containing 1 2 2
MIRT462778 ZNF8 zinc finger protein 8 2 2
MIRT463416 ZC3HAV1L zinc finger CCCH-type containing, antiviral 1 like 2 2
MIRT463660 YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta 2 2
MIRT464263 VCL vinculin 2 2
MIRT465128 TSC22D2 TSC22 domain family member 2 2 4
MIRT466187 TMED5 transmembrane p24 trafficking protein 5 2 4
MIRT466723 SYNJ2BP synaptojanin 2 binding protein 2 2
MIRT469100 RNF144B ring finger protein 144B 2 2
MIRT469716 RAB40C RAB40C, member RAS oncogene family 2 2
MIRT470420 PPP1R15B protein phosphatase 1 regulatory subunit 15B 2 2
MIRT470681 POLR2D RNA polymerase II subunit D 2 4
MIRT470863 PLXND1 plexin D1 2 2
MIRT471273 PGM2L1 phosphoglucomutase 2 like 1 2 2
MIRT471964 NR6A1 nuclear receptor subfamily 6 group A member 1 2 2
MIRT472674 NAA20 N(alpha)-acetyltransferase 20, NatB catalytic subunit 2 2
MIRT472734 MTUS1 microtubule associated scaffold protein 1 2 6
MIRT473130 MLLT10 MLLT10, histone lysine methyltransferase DOT1L cofactor 2 2
MIRT473238 SMCR7L mitochondrial elongation factor 1 1 4
MIRT473826 MAP2K7 mitogen-activated protein kinase kinase 7 2 2
MIRT473938 LYN LYN proto-oncogene, Src family tyrosine kinase 2 2
MIRT474026 LRRC20 leucine rich repeat containing 20 2 2
MIRT474503 KLHDC8B kelch domain containing 8B 2 2
MIRT474764 KIAA0930 KIAA0930 2 2
MIRT474909 KCTD21 potassium channel tetramerization domain containing 21 2 2
MIRT475329 IFNLR1 interferon lambda receptor 1 2 2
MIRT475377 ICOSLG inducible T-cell costimulator ligand 2 2
MIRT475731 HERPUD1 homocysteine inducible ER protein with ubiquitin like domain 1 2 4
MIRT476546 GABPB1 GA binding protein transcription factor beta subunit 1 2 4
MIRT476979 FAM83G family with sequence similarity 83 member G 2 4
MIRT477680 EFHD2 EF-hand domain family member D2 2 2
MIRT479748 CCND1 cyclin D1 2 2
MIRT481191 ATXN7L3B ataxin 7 like 3B 2 4
MIRT481234 ATXN7L3 ataxin 7 like 3 2 2
MIRT481361 ATG9A autophagy related 9A 2 2
MIRT481386 ATG12 autophagy related 12 2 2
MIRT481650 AREL1 apoptosis resistant E3 ubiquitin protein ligase 1 2 2
MIRT481850 AP1S1 adaptor related protein complex 1 sigma 1 subunit 2 2
MIRT482182 AHR aryl hydrocarbon receptor 2 2
MIRT482218 AHCYL2 adenosylhomocysteinase like 2 2 2
MIRT485294 PLAGL2 PLAG1 like zinc finger 2 2 2
MIRT486657 ZNF28 zinc finger protein 28 2 2
MIRT489411 TUBB2A tubulin beta 2A class IIa 2 2
MIRT491858 ZBTB5 zinc finger and BTB domain containing 5 2 8
MIRT492212 SOCS1 suppressor of cytokine signaling 1 2 2
MIRT492627 PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 2 2
MIRT493327 LIMD2 LIM domain containing 2 2 2
MIRT493899 FAM43A family with sequence similarity 43 member A 2 4
MIRT494261 CEP120 centrosomal protein 120 2 2
MIRT494683 ARID3A AT-rich interaction domain 3A 2 2
MIRT495966 TBC1D19 TBC1 domain family member 19 2 2
MIRT496109 SNX17 sorting nexin 17 2 2
MIRT497873 SLC12A7 solute carrier family 12 member 7 2 2
MIRT498120 PLEKHO1 pleckstrin homology domain containing O1 2 4
MIRT499403 PLCG2 phospholipase C gamma 2 2 4
MIRT499491 GGA3 golgi associated, gamma adaptin ear containing, ARF binding protein 3 2 2
MIRT499651 SDR42E1 short chain dehydrogenase/reductase family 42E, member 1 2 2
MIRT499940 MFSD8 major facilitator superfamily domain containing 8 2 2
MIRT499995 HIST1H2BD histone cluster 1 H2B family member d 2 4
MIRT500905 STRN striatin 2 4
MIRT501114 SLC5A6 solute carrier family 5 member 6 2 4
MIRT501177 SLC10A7 solute carrier family 10 member 7 2 6
MIRT501208 SUMO1 small ubiquitin-like modifier 1 2 2
MIRT501244 SEMA4C semaphorin 4C 2 6
MIRT501330 RNFT1 ring finger protein, transmembrane 1 2 2
MIRT501353 RNF44 ring finger protein 44 2 4
MIRT501391 RBFOX2 RNA binding protein, fox-1 homolog 2 2 10
MIRT501436 RAB11FIP4 RAB11 family interacting protein 4 2 2
MIRT501756 NSD1 nuclear receptor binding SET domain protein 1 2 2
MIRT501947 MBD2 methyl-CpG binding domain protein 2 2 8
MIRT502105 KPNA5 karyopherin subunit alpha 5 2 8
MIRT502131 KMT2D lysine methyltransferase 2D 2 4
MIRT502786 CEP135 centrosomal protein 135 2 2
MIRT502844 CELF1 CUGBP Elav-like family member 1 2 2
MIRT504787 C12orf4 chromosome 12 open reading frame 4 2 2
MIRT505021 ZNF644 zinc finger protein 644 2 2
MIRT505578 SMC1A structural maintenance of chromosomes 1A 2 6
MIRT506363 NUP155 nucleoporin 155 2 6
MIRT506934 IGDCC4 immunoglobulin superfamily DCC subclass member 4 2 6
MIRT507249 FIGN fidgetin, microtubule severing factor 2 8
MIRT507695 COIL coilin 2 6
MIRT508399 C1orf210 chromosome 1 open reading frame 210 2 6
MIRT508663 DIABLO diablo IAP-binding mitochondrial protein 2 4
MIRT508930 AK4 adenylate kinase 4 2 4
MIRT510398 ZNF566 zinc finger protein 566 2 6
MIRT510517 YOD1 YOD1 deubiquitinase 2 6
MIRT511384 IKZF3 IKAROS family zinc finger 3 2 4
MIRT512743 CD59 CD59 molecule (CD59 blood group) 2 4
MIRT515952 C9orf156 tRNA methyltransferase O 2 2
MIRT516081 ZBTB8OS zinc finger and BTB domain containing 8 opposite strand 2 4
MIRT521388 RDX radixin 2 4
MIRT522347 NCKIPSD NCK interacting protein with SH3 domain 2 4
MIRT523624 FZD9 frizzled class receptor 9 2 4
MIRT523731 FBXW2 F-box and WD repeat domain containing 2 2 4
MIRT523988 DVL3 dishevelled segment polarity protein 3 2 2
MIRT524114 DNA2 DNA replication helicase/nuclease 2 2 2
MIRT525725 SOD2 superoxide dismutase 2 2 2
MIRT527761 RRAD RRAD, Ras related glycolysis inhibitor and calcium channel regulator 2 2
MIRT529725 OPRL1 opioid related nociceptin receptor 1 2 2
MIRT533186 WASL Wiskott-Aldrich syndrome like 2 6
MIRT536376 LEFTY1 left-right determination factor 1 2 2
MIRT543783 RBM12B RNA binding motif protein 12B 2 4
MIRT543866 SLC16A9 solute carrier family 16 member 9 2 2
MIRT545385 PM20D2 peptidase M20 domain containing 2 2 2
MIRT545889 ZNF200 zinc finger protein 200 2 4
MIRT546331 TGFBR3 transforming growth factor beta receptor 3 2 2
MIRT547376 MSI2 musashi RNA binding protein 2 2 2
MIRT547574 LRIG3 leucine rich repeats and immunoglobulin like domains 3 2 4
MIRT547835 IGF2BP3 insulin like growth factor 2 mRNA binding protein 3 2 4
MIRT548263 FBXL20 F-box and leucine rich repeat protein 20 2 2
MIRT548349 EPHA4 EPH receptor A4 2 2
MIRT548530 DUSP1 dual specificity phosphatase 1 2 2
MIRT548558 DNAL1 dynein axonemal light chain 1 2 2
MIRT548778 COLEC12 collectin subfamily member 12 2 2
MIRT548973 CCNT2 cyclin T2 2 2
MIRT549023 CBX5 chromobox 5 2 2
MIRT549210 BEND4 BEN domain containing 4 2 4
MIRT549761 ZNF611 zinc finger protein 611 2 6
MIRT549797 KIAA0391 KIAA0391 2 2
MIRT549845 ECHDC1 ethylmalonyl-CoA decarboxylase 1 2 2
MIRT550725 PMPCA peptidase, mitochondrial processing alpha subunit 2 4
MIRT550896 ACTA1 actin, alpha 1, skeletal muscle 2 2
MIRT551281 MCF2L2 MCF.2 cell line derived transforming sequence-like 2 2 6
MIRT551316 GSG2 histone H3 associated protein kinase 2 6
MIRT551930 AKAP8 A-kinase anchoring protein 8 2 4
MIRT552001 RAD18 RAD18, E3 ubiquitin protein ligase 2 2
MIRT552408 ZNF460 zinc finger protein 460 2 4
MIRT553015 USP38 ubiquitin specific peptidase 38 2 2
MIRT555548 PLEKHA3 pleckstrin homology domain containing A3 2 2
MIRT555713 PDZD8 PDZ domain containing 8 2 2
MIRT557379 HAND1 heart and neural crest derivatives expressed 1 2 2
MIRT557963 FAM222B family with sequence similarity 222 member B 2 2
MIRT559083 C19orf47 chromosome 19 open reading frame 47 2 4
MIRT559495 ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 2 2
MIRT561780 PEG10 paternally expressed 10 2 2
MIRT564400 EMILIN2 elastin microfibril interfacer 2 2 4
MIRT565447 SURF4 surfeit 4 2 2
MIRT566516 PARP16 poly(ADP-ribose) polymerase family member 16 2 2
MIRT567433 GNG5 G protein subunit gamma 5 2 2
MIRT567713 E2F6 E2F transcription factor 6 2 2
MIRT568659 ABHD17C abhydrolase domain containing 17C 2 2
MIRT569496 THYN1 thymocyte nuclear protein 1 2 2
MIRT573818 TGOLN2 trans-golgi network protein 2 2 2
MIRT574361 ZBTB37 zinc finger and BTB domain containing 37 2 2
MIRT574745 GOLGA4 golgin A4 2 2
MIRT574784 FAM104A family with sequence similarity 104 member A 2 2
MIRT576084 Poteg POTE ankyrin domain family, member G 2 2
MIRT576809 Thbs1 thrombospondin 1 2 3
MIRT616368 RWDD1 RWD domain containing 1 2 2
MIRT617849 FMO4 flavin containing monooxygenase 4 2 2
MIRT642392 ZNF556 zinc finger protein 556 2 2
MIRT680517 PRIM2 DNA primase subunit 2 2 2
MIRT680545 ZNF584 zinc finger protein 584 2 2
MIRT680798 ZNF578 zinc finger protein 578 2 2
MIRT680836 ARL8B ADP ribosylation factor like GTPase 8B 2 2
MIRT681139 INTS7 integrator complex subunit 7 2 2
MIRT681269 RFC2 replication factor C subunit 2 2 2
MIRT681321 ZFAND4 zinc finger AN1-type containing 4 2 4
MIRT681357 BRI3BP BRI3 binding protein 2 2
MIRT681504 STAT2 signal transducer and activator of transcription 2 2 2
MIRT681534 ZNF738 zinc finger protein 738 2 2
MIRT681656 DTX3L deltex E3 ubiquitin ligase 3L 2 2
MIRT681736 RAB19 RAB19, member RAS oncogene family 2 4
MIRT681759 CDKAL1 CDK5 regulatory subunit associated protein 1 like 1 2 2
MIRT681795 EIF4A3 eukaryotic translation initiation factor 4A3 2 2
MIRT681867 DNAH9 dynein axonemal heavy chain 9 2 2
MIRT681939 SLC19A3 solute carrier family 19 member 3 2 2
MIRT682100 ITGA3 integrin subunit alpha 3 2 4
MIRT682179 SLC38A7 solute carrier family 38 member 7 2 2
MIRT682236 SAR1A secretion associated Ras related GTPase 1A 2 2
MIRT682382 PHACTR4 phosphatase and actin regulator 4 2 2
MIRT682442 MTX3 metaxin 3 2 2
MIRT682602 CPA4 carboxypeptidase A4 2 2
MIRT682638 COX6B1 cytochrome c oxidase subunit 6B1 2 2
MIRT689325 FPR1 formyl peptide receptor 1 2 2
MIRT689728 ATXN2 ataxin 2 2 2
MIRT691034 ZNF799 zinc finger protein 799 2 2
MIRT691933 DNAJC28 DnaJ heat shock protein family (Hsp40) member C28 2 2
MIRT694882 ZNF417 zinc finger protein 417 2 2
MIRT695253 ZNF443 zinc finger protein 443 2 2
MIRT695411 ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide 2 2
MIRT700591 PRSS22 protease, serine 22 2 2
MIRT701432 NHLRC2 NHL repeat containing 2 2 2
MIRT702482 KIAA1328 KIAA1328 2 2
MIRT702708 IPO9 importin 9 2 2
MIRT704033 EDEM3 ER degradation enhancing alpha-mannosidase like protein 3 2 2
MIRT704421 CTPS1 CTP synthase 1 2 2
MIRT705748 AMD1 adenosylmethionine decarboxylase 1 2 2
MIRT712368 NAP1L1 nucleosome assembly protein 1 like 1 2 2
MIRT713518 PAFAH2 platelet activating factor acetylhydrolase 2 2 2
MIRT732950 HOXB1 homeobox B1 3 0
MIRT735294 MMP16 matrix metallopeptidase 16 3 0
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
let-7g Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) NULL 8490 Microarray mouse brain 19270793 2009 up-regulated
let-7g Leptin NULL NULL Quantitative real-time PCR muscles 20800581 2010 down-regulated
let-7g 17beta-estradiol (E2) approved 5757 Microarray MCF-7 breast cancer cells 19528081 2009 up-regulated
let-7g Etoposide approved 36462 Microarray Normal human fibroblasts (AG01522) 19633716 2009 up-regulated
let-7g Bisphenol A NULL 6623 Microarray immortalized cytotrophoblast cell lines 3A 20417706 2010 up-regulated
let-7g Bisphenol A NULL 6623 Microarray immortalized cytotrophoblast cell lines HTR-8 20417706 2010 up-regulated
let-7g Formaldehyde NULL 712 Microarray Human lung epithelial cells (A549) 21147603 2011 down-regulated
let-7g 5-Fluorouracil approved 3385 Microarray MCF-7 breast cancer cells 21506117 2011 down-regulated
let-7g 5-Fluorouracil approved 3385 Quantitative real-time PCR MCF-7 breast cancer cells 21506117 2011 down-regulated
let-7g Arsenic trioxide approved 14888 Quantitative real-time PCR acute promyelocytic leukemia 22072212 2012 up-regulated
let-7g 5-aza-2'-deoxycytidine (5-Aza-CdR) approved 451668 Microarray breast cancer MDA-MB231 22076154 2011 down-regulated
let-7g 5-aza-2'-deoxycytidine (5-Aza-CdR) approved 451668 Microarray breast cancer SKBR3 22076154 2011 down-regulated
let-7g Marine fungal metabolite 1386A NULL NULL Microarray MCF-7 breast cancer cells. 22159329 2012 up-regulated
let-7g 17beta-estradiol (E2) approved 5757 Microarray MCF-7 breast cancer cell line 22403704 2012 down-regulated
let-7g Bisphenol A NULL 6623 Microarray MCF-7 breast cancer cell line 22403704 2012 down-regulated
let-7g Doxorubicin approved 31703 Quantitative real-time PCR myocardial injury 22301161 2012 down-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-let-7g Doxorubicin 31703 NSC123127 approved resistant High Breast Cancer cell line (MCF-7)
hsa-let-7g Doxorubicin 31703 NSC123127 approved sensitive High Breast Cancer cell line (MCF-7)
hsa-let-7g Verapamil 2520 NSC272366 approved sensitive High Breast Cancer cell line (MCF-7)
hsa-let-7g Cisplatin 5460033 NSC119875 approved resistant High Tongue Squamous Cell Carcinoma cell line (Tca8113)
hsa-let-7g Doxorubicin 31703 NSC123127 approved sensitive High Leukemia cell line (K562)
hsa-let-7g 10-Hydroxycamptothecin 97226 NSC107124 resistant High Gastric Cancer cell line (BGC823, SGC-7901, MGC-803, HGC-27, NCI-N87, AGS)
hsa-let-7g Modified Allic Bfm 2002 Protocol sensitive High Childhood Acute Lymphoblastic Leukemia tissue
hsa-let-7g Fluorouracil 3385 NSC19893 approved resistant High Colon Cancer cell line (DLD-1)
hsa-let-7g Cisplatin 5460033 NSC119875 approved resistant High Ovarian Cancer cell line (SKOV3)
hsa-let-7g Fluorouracil + Oxaliplatin resistant High Colorectal Cancer tissue
hsa-let-7g Cisplatin 5460033 NSC119875 approved resistant High Ovarian Cancer cell line (C13*, A2780, OV2008)
hsa-let-7g Fluorouracil 3385 NSC19893 approved sensitive Low Hepatoma cell line (BEL-7402)
hsa-let-7g Cisplatin 5460033 NSC119875 approved sensitive High Ovarian Cancer cell line (COC1)
hsa-let-7g Paclitaxel 36314 NSC125973 approved sensitive High Lung Adenocarcinoma cell line (A549)
hsa-let-7g Cisplatin 5460033 NSC119875 approved sensitive Low Esophageal Cancer cell line (EC109, TE10)
hsa-let-7g Cisplatin 5460033 NSC119875 approved sensitive Low Esophageal Cancer cell line (EC109, TE10)
hsa-let-7g Cisplatin 5460033 NSC119875 approved sensitive Low Cervical Cancer tissue
hsa-let-7g Cisplatin 5460033 NSC119875 approved sensitive Low Epithelial Ovarian Cancer cell line (OVCAR3, HEY-A8)
hsa-let-7g Oxaliplatin 6857599 NSC266046 approved sensitive Low Colorectal Cancer cell line (HCT-116)
hsa-let-7g Gefitinib 123631 NSC715055 approved sensitive Low Non-Small Cell Lung Cancer cell line (PC-9)
hsa-let-7g Dabrafenib 44462760 NSC764134 approved sensitive cell line (A375)
hsa-let-7g Cisplatin 5460033 NSC119875 approved sensitive cell line (CIS)
hsa-let-7g Testosterone+Letrozole resistant cell line (MCF-7)
hsa-let-7g Testosterone+Tamoxifen resistant cell line (MCF-7)
hsa-let-7g Cisplatin 5460033 NSC119875 approved resistant cell line (RPMI2650)
hsa-let-7g Sunitinib 5329102 NSC750690 approved resistant tissue (CardA)
hsa-let-7g Paclitaxel 36314 NSC125973 approved resistant cell line (SKOV3)
hsa-let-7g Pegylated interferon alpha+Ribavirin resistant tissue (chronic hepatitis C)
hsa-let-7g Cisplatin 5460033 NSC119875 approved resistant cell line (KYSE)
hsa-let-7g Paclitaxel 36314 NSC125973 approved resistant cell line (PC3PR70)
hsa-let-7g Bortezomib 387447 NSC681239 approved sensitive cell line (CCRF-CEM) (100 nM)
hsa-let-7g Bortezomib 387447 NSC681239 approved resistant cell line (CCRF-CEM) (200 nM)
hsa-let-7g Cisplatin 5460033 NSC119875 approved resistant cell line (A2780)
hsa-let-7g Paclitaxel/Docetaxel/Vinorelbine/Doxorubicin/Etoposide/Methotrexate/Gemcitabine resistant cell line (Bats-72)
hsa-let-7g-5p 1h-indole-3-methanol, 1-[(4-chlorophenyl)methyl]- 11821732 NSC741909 resistant
hsa-let-7g-5p N'-(cyano(3-hydroxyphenyl)methyl)-2-hydroxybenzohydrazide 375018 NSC653844 resistant
hsa-let-7g-5p N-(5-aminopentyl)-n-(3-aminopropoxy)-2,2,5,7,8-pentamethyl-3,4-dihydrochromene-6-sulfonamide;hydrochloride 396614 NSC703117 sensitive
hsa-let-7g-5p Vfbduqdkojtrni-pknbqfbnsa-n 5468519 NSC671184 sensitive
hsa-let-7g-5p Tamoxifen 2733525 NSC180973 approved sensitive High Breast Cancer cell line (MCF-7)
hsa-let-7g-5p Paclitaxel 36314 NSC125973 approved sensitive High Lung Adenocarcinoma cell line (A549)
hsa-let-7g-5p Platinum 23939 resistant Low Ovarian Cancer tissue
hsa-let-7g-5p Cisplatin 5460033 NSC119875 approved sensitive High Gastric Cancer cell line (SGC7901)
hsa-let-7g-5p Trametinib 11707110 NSC758246 approved resistant High Melanoma cell line (WM266) (1uM)
hsa-let-7g-5p Trametinib 11707110 NSC758246 approved resistant High Melanoma cell line (WM266) (2uM)
hsa-let-7g-5p Vemurafenib 42611257 NSC761431 approved resistant High Melanoma cell line (WM266) (1uM)
hsa-let-7g-5p Vemurafenib 42611257 NSC761431 approved resistant High Melanoma cell line (WM266) (2uM)
hsa-let-7g-5p Radioactivity Iodine sensitive High Papillary Thyroid Cancer tissue
hsa-let-7g-5p Cisplatin 5460033 NSC119875 approved resistant High Ovarian Cancer cell line (A2780)
hsa-let-7g-5p Paclitaxel 36314 NSC125973 approved sensitive High Endometrial Serous Carcinoma cell line (USPC1)
hsa-let-7g-5p Temozolomide 5394 NSC362856 approved sensitive Low Glioblastoma cell line (U87, U251, HEK)
hsa-let-7g-5p Oxaliplatin 6857599 NSC266046 approved sensitive High Colorectal Cancer tissue
hsa-let-7g-5p Cisplatin 5460033 NSC119875 approved resistant High Ovarian Cancer cell line (A2780CIS)
hsa-let-7g-5p Docetaxel 148124 NSC628503 approved sensitive High Breast Cancer cell line (MDA-MB-231, MCF-7)
hsa-let-7g-5p Temozolomide 5394 NSC362856 approved resistant cell line (U251)
hsa-let-7g-5p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-let-7g-5p Vemurafenib 42611257 NSC761431 approved sensitive cell line (451Lu)
hsa-let-7g-5p Palbociclib 5330286 NSC758247 approved sensitive tissue (breast cancer)
hsa-let-7g-5p Prednisone/Azathioprine/Methotrexate/Cyclophosphamide/Mycophenolate mofetil sensitive tissue (myasthenia gravis)
hsa-let-7g-5p Vemurafenib 42611257 NSC761431 approved resistant cell line (LM11)
hsa-let-7g-5p Paclitaxel 36314 NSC125973 approved sensitive cell line (BAS)
hsa-let-7g-5p Doxorubicin 31703 NSC123127 approved sensitive cell line (BAS)
hsa-let-7g-5p Cisplatin 5460033 NSC119875 approved resistant cell line (CIS)
hsa-let-7g-5p Osimertinib 71496458 NSC779217 approved sensitive cell line (H1975)
hsa-let-7g-5p Fluorouracil 3385 NSC19893 approved sensitive cell line (HCT15)
hsa-let-7g-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (MGC-803)
hsa-let-7g-5p Vemurafenib 42611257 NSC761431 approved resistant cell line (LM16)
hsa-let-7g-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)

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