miRTarBase - #MIRT049998


—
pre-miRNA Information
pre-miRNA hsa-mir-28   
Genomic Coordinates chr3: 188688781 - 188688866
Synonyms MIRN28, hsa-mir-28, miR-28, MIR28
Description Homo sapiens miR-28 stem-loop
Comment None
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-28-5p
Sequence 14| AAGGAGCUCACAGUCUAUUGAG |35
Evidence Experimental
Experiments Cloned
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 2 3 + 188688795 29233923 MiREDiBase
A-to-I 5 3 + 188688798 29233923 MiREDiBase
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSN18185224 6 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1466099417 7 dbSNP
rs1333243027 9 dbSNP
rs1211406812 12 dbSNP
rs1380324091 13 dbSNP
rs1350747725 14 dbSNP
rs564264103 17 dbSNP
rs1315387654 18 dbSNP
rs1380847802 20 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol ZBTB47   
Synonyms ZNF651
Description zinc finger and BTB domain containing 47
Transcript NM_145166   
Expression
Putative miRNA Targets on ZBTB47
3'UTR of ZBTB47
(miRNA target sites are highlighted)		 
>ZBTB47|NM_145166|3'UTR
   1 CTGCCGAGCTGCACCCGTGCACCCGCTGGGGCCTGGAGTCAGGGCCCACTCCAGGAGGGACCCACTGCCTTCCCGGGGAG
  81 CACAGTAGTGCGGGCCTGGGCCCTGCTCCACCTCCAGAAGTGGCTGGATGTACCCTGCCTGAGGCCCCGACGAGGAGGGG
 161 TATGCAGGCTGGCAGGCCCCAGAGCTGGTGGAGGGCATCTCACTCCCAAGTGCCCCCCCTTTCTGTGACTCCTTGAAGCC
 241 TTTACTTTTTTTTTTTTTTGGAAGTGAAGGAAAAAGAAACTATTTACAGCACTCCCCTCCAGGTGAGGGGGGTGCTGGGG
 321 GTCTGCAGCAGAAAGAAAGGGGCCTGGGCAGCAGGTGTGGCCAGTCCCTCTGCCAAGGCCTGTGCCAGAGGGGTTGGCCA
 401 GTTGGAGCCTGGGTCAGCCTCAGCAGCCTATCCCCATGTCCTCTATGCCCCTAATTTGCTTCCTCATCTTGGAGGGTTTG
 481 GGGAGAAGTTGGCGTGCCACCCCCACAACCCCTGAGGAGGTGTAGACCCAGTCTGAGAGCCGCAAGCACTGAGGCAGGGC
 561 CTGAGACTGGACCTGGGTGAGCGTGGGGGGTGGAGGGTGGCGAGGTGCGGAGACTGCAGACCAGTGCTTCACTGTGTGGA
 641 GTGGGGCAGGCAGGGGCTGGACCCCAGGGACTTGCCTTCCCCACCCACTCTGCTGCCAGCAGGCCCAGGGATCCCTGACC
 721 TGCACCAGGTGGCACCAAGGGTCCTGAGTCCTGGAGATGTCCCCAGAAGCTGCTGTGCCTCACAGCGCTGTGAGCCAGAC
 801 CCTCCTTGGGCAGACAGGCTGACTGGCAGCACCAGCTTTGGGGGCAGAGTCCTAGGATGAGGCTTGGGCAGTGCTGGTAG
 881 GGTTTCAAGGTGCTATTAGTGGGGCAGGGGCAGGGCGGCTGCTCACAGAGCACCCCAGTTCCTCACCAGCTACTCTGGCC
 961 ATATATCCCACACCAGAAGGAACAAGTGTGGCTGTGTCCATCTCTGCTCCCCCAAAGGCCCGCTCTAGGCCTTATCCTCC
1041 CTCTAGGTCCTGCCACAACCTGTCCCTGGCTGGCTCCAGCGTCCTCGTCCCTCCTGGGCCTGTGCACCGGTGGGTGGGGC
1121 GCCCATAGCACTGCCGGTAAAGGAGCCTGCATGTTCAGGCCCCTCGGGGGATTGGGGGGACTGGGGAGGCGCAGCCTAGA
1201 CCCAATTGCTTGCCCCCATGAGGCTAGCACTAATAGGAAACCCTTTTTTGTTGTCATTTAATGTCTTTATTCCTGCCTTT
1281 AATATGGGGAGGAAGGTTCCATAAGCTACATGTTTCCTAGTTAAGCTCTTTCCTATTGTGTTTATACAGTTTTGTTTGTT
1361 ATACTCTTTGCACCTTAAACCCCCACCACTCCCCGACACTATTGCCTTCCCAGCATGGCTGGAGTGGGAAGAGGCTTGGG
1441 CCCCGGGGGAATGGTTAGGGGGACTGAACCCCTCTGACCTTATGAGGCCCATGGCACTGGGGCAGGGAGCTGGGGACATT
1521 TTAATCATCAATAAACGAAGCACTTTATTCTGTACAGATTTGGGCAGGCCCAAGGTGCCCGAGTGATCTGAGGATTTATA
1601 ATCCAAGCCACACCACCCTGGTTGTTCTCTGGGCTTGGAGGGTACAGTGCCAGCAGCTTCCTTGCCCAATTGATGTTGGA
1681 GCTGTAGACGTACGCTCAGGCGCTCCTGCTGTCCTGGGGGAGAGAAGGTTCGCCCCTCCCCGAGGAAGAAGGCTTCTGGT
1761 CAGGACCCCCACCCCAAGGCTGGGGACTCCAGGCTCCTGCTTTACTGTAGCTCTTTTTCTTCCTTGCACTCCTTGATCTT
1841 TGGGCTTCCGTGATGTCCTCAGGGTCCCCCCCTCCCTGTTGCTATTTTTAATCTCTAGTCCCAGTGCCTGGCAGCTCTTT
1921 GGAGCTGGCTCACATTTTCCCAAAAAAAGTTGATCTCTCCCAGTGGGCTGTAGGCAGGGTCCTCCATGGGTTTCCAACCC
2001 CCATCACTGGCACCAGGATCTCCCACAGGCACTGGTGGTGTCATCACCTGCTGGCCCCACTACAGCCTGAGTAGGCCTGA
2081 GTGGCCGTGGCCAGGCTGAGACCTGTCAGGCCATACTGACAAGCAGAGGTCAGAGACACTGGTGGGGAGCTGGCAATGAA
2161 ACCCTGTCCTGGGACATGGGTTTCATGTTCTTGTACACTTCCCCTCTGGGATCAGGTGAGGGGTCCAGACAGCTGACCAG
2241 ACAGCTTGACAGCTGGTCAAGACGGTCACGGGAGCTCTAGGTGGGCACAACCAACCCCTCTCCTGGGAGGCCCCTGCCCC
2321 ACTGGGGATAGGAGCCTGTGTCCCTGGTGCTAAGCACTCTCTTCACTTGGGCCATTGTTGGTGGGGGCTCCTTTCCGGCC
2401 AGACCACAAGGCCAGAAGCAATAATGGCACCTCAGCAGTTCCAGTATGGATAGGGGTTCCTGTTTTACTAGCTTTTACAT
2481 CTTTTTATTTAAAACAAAACAACACAAAAAAACAATGTGCCCCCAGATGTCAGAATGAGGCGACTAGGGCACCATACTCA
2561 CTTTCCAGGGCTGGGGGAAGGGGGACGCAGGATCATCCCCTCCCAAGGAGATCTGTGGGGGTCCCACCGTCCATCTGGAC
2641 TTCTCAGCCTGTTTGGCTAGAACTCAGGCCTGGAGTCTGGGTCTGCCCCCTCCCCGGCTCCTTGGGGCTCTCTGGTCTCA
2721 GGCCAGCTGGCGATGGGTGGCTAGAGTGATGAACTCAAGCCCTGTGGCCACAGTTCTGGGAGCCTTCAACCCTGGCTCAT
2801 GCTGCCATAGTCTCCACGGTGCCCTTCACAGAGGGCTTGGTAGTGGCAGAATGGCCATGCCCAGGTGTGTGTTGAGACCA
2881 TTGACAACTGCTCGTGTACAGGCACCCCACAGCCCCAGAGCATGGGGCACAGCAGGCATGCGAGTGAGAGGATGAAGGGG
2961 AATAAAGTCAGTACAACTCGTGAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' gaGUUAUCUGACACUCGAGGAa 5'
            ||:| | |||  |||||:| 
Target 5' ccCAGT-GCCTGGCAGCTCTTt 3'
 1900 - 1920 143.00 -14.10
2 
miRNA  3' gaguuaucUGACACUCGAGGAa 5'
                  ||||| |||||:| 
Target 5' cctgctttACTGT-AGCTCTTt 3'
 1796 - 1816 141.00 -13.60
3 
miRNA  3' gaGUUAUC--UGACACUCGAGGAa 5'
            | || |  : || |:|||||| 
Target 5' ggCCATTGTTGGTGGGGGCTCCTt 3'
 2370 - 2393 138.00 -15.80
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN2477051 44 COSMIC
COSN31959864 55 COSMIC
COSN20098341 260 COSMIC
COSN29189099 520 COSMIC
COSN18891174 530 COSMIC
COSN1277129 669 COSMIC
COSN30172441 711 COSMIC
COSN30541639 773 COSMIC
COSN20090805 855 COSMIC
COSN24494449 901 COSMIC
COSN28321346 1001 COSMIC
COSN1950030 1035 COSMIC
COSN28651748 1192 COSMIC
COSN15866042 1241 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1324911804 10 dbSNP
rs1232535206 12 dbSNP
rs891407035 14 dbSNP
rs1254346196 17 dbSNP
rs769603715 18 dbSNP
rs1205934219 19 dbSNP
rs1378349806 19 dbSNP
rs1262790320 21 dbSNP
rs1405459655 24 dbSNP
rs964397476 29 dbSNP
rs976429197 32 dbSNP
rs923188749 33 dbSNP
rs1007058066 34 dbSNP
rs1191264158 36 dbSNP
rs1040300915 37 dbSNP
rs955907213 40 dbSNP
rs1240008337 43 dbSNP
rs988571999 46 dbSNP
rs996009464 55 dbSNP
rs1025626754 58 dbSNP
rs1348157444 62 dbSNP
rs1293219535 63 dbSNP
rs951362988 73 dbSNP
rs1355040420 74 dbSNP
rs914664287 75 dbSNP
rs1382078272 76 dbSNP
rs1334956531 79 dbSNP
rs1397974034 92 dbSNP
rs1383158565 93 dbSNP
rs947437354 95 dbSNP
rs1024888813 96 dbSNP
rs1044417795 113 dbSNP
rs927308124 117 dbSNP
rs1161550304 125 dbSNP
rs1443954689 134 dbSNP
rs1385286833 135 dbSNP
rs1189068976 137 dbSNP
rs1444922428 142 dbSNP
rs1228839741 146 dbSNP
rs1260682071 149 dbSNP
rs938692013 152 dbSNP
rs1244358676 153 dbSNP
rs1359421012 162 dbSNP
rs1284847972 164 dbSNP
rs1057414571 169 dbSNP
rs1324775862 176 dbSNP
rs1356819547 177 dbSNP
rs1317816552 178 dbSNP
rs1400872140 188 dbSNP
rs541667335 194 dbSNP
rs994340097 195 dbSNP
rs1423888984 196 dbSNP
rs1048568572 198 dbSNP
rs925135386 200 dbSNP
rs368555727 206 dbSNP
rs1372005640 213 dbSNP
rs1474110158 213 dbSNP
rs561855202 213 dbSNP
rs887546541 215 dbSNP
rs1478612378 216 dbSNP
rs1265768897 217 dbSNP
rs1006411806 218 dbSNP
rs1017337215 219 dbSNP
rs964771512 220 dbSNP
rs1337481197 221 dbSNP
rs1269691435 233 dbSNP
rs1193466294 240 dbSNP
rs1219452862 242 dbSNP
rs1342651736 245 dbSNP
rs905090362 245 dbSNP
rs11458566 246 dbSNP
rs1408073575 246 dbSNP
rs1428476967 246 dbSNP
rs1428348186 248 dbSNP
rs397816305 260 dbSNP
rs1189604760 261 dbSNP
rs1392257411 262 dbSNP
rs1422916530 263 dbSNP
rs1163035434 265 dbSNP
rs1350505302 266 dbSNP
rs1003225878 277 dbSNP
rs1198254108 291 dbSNP
rs1459484332 294 dbSNP
rs1247687650 297 dbSNP
rs1201579314 302 dbSNP
rs1436624524 307 dbSNP
rs1272333645 308 dbSNP
rs1287095730 309 dbSNP
rs997131671 310 dbSNP
rs1320258114 311 dbSNP
rs1261435205 312 dbSNP
rs533122524 313 dbSNP
rs932982102 314 dbSNP
rs1335141996 318 dbSNP
rs1051417928 321 dbSNP
rs912796471 330 dbSNP
rs1435633101 340 dbSNP
rs547093278 341 dbSNP
rs1299466744 344 dbSNP
rs1175213557 346 dbSNP
rs1414702059 348 dbSNP
rs1380150994 356 dbSNP
rs868184984 359 dbSNP
rs1426279344 367 dbSNP
rs79618755 371 dbSNP
rs748977373 374 dbSNP
rs1290108529 385 dbSNP
rs914380024 387 dbSNP
rs1238166051 390 dbSNP
rs1179831189 392 dbSNP
rs968560831 393 dbSNP
rs1213015474 399 dbSNP
rs768138492 403 dbSNP
rs927390448 407 dbSNP
rs1209622716 412 dbSNP
rs566903943 429 dbSNP
rs1057115728 431 dbSNP
rs1221930113 433 dbSNP
rs1349703993 437 dbSNP
rs918860397 438 dbSNP
rs1013588425 444 dbSNP
rs1443046125 449 dbSNP
rs1335552829 452 dbSNP
rs1183268122 466 dbSNP
rs1414776895 468 dbSNP
rs1425695639 476 dbSNP
rs1360603857 477 dbSNP
rs1336540367 489 dbSNP
rs1399264286 493 dbSNP
rs867102460 494 dbSNP
rs532564254 495 dbSNP
rs905094382 501 dbSNP
rs1002541411 506 dbSNP
rs1181398893 508 dbSNP
rs1483700039 514 dbSNP
rs1239370580 523 dbSNP
rs1032139977 524 dbSNP
rs1457651011 528 dbSNP
rs1322333784 529 dbSNP
rs1403682767 534 dbSNP
rs1487816199 535 dbSNP
rs1048663685 536 dbSNP
rs987970652 542 dbSNP
rs888636479 543 dbSNP
rs942881890 544 dbSNP
rs1228450612 545 dbSNP
rs1380730828 551 dbSNP
rs373596339 557 dbSNP
rs1221577181 558 dbSNP
rs900216692 564 dbSNP
rs1360238059 568 dbSNP
rs1299245937 571 dbSNP
rs1422027897 574 dbSNP
rs1305596956 578 dbSNP
rs569450337 583 dbSNP
rs1229511510 584 dbSNP
rs1270546749 585 dbSNP
rs1424400930 585 dbSNP
rs1416089254 586 dbSNP
rs1184951802 587 dbSNP
rs910224156 588 dbSNP
rs1263586053 589 dbSNP
rs1029931207 591 dbSNP
rs866487176 592 dbSNP
rs538523636 594 dbSNP
rs1264728953 595 dbSNP
rs1222226612 596 dbSNP
rs1322961401 598 dbSNP
rs976072740 600 dbSNP
rs376668432 602 dbSNP
rs1010139349 603 dbSNP
rs68190114 606 dbSNP
rs1293414552 609 dbSNP
rs968988132 610 dbSNP
rs887171177 632 dbSNP
rs1484322088 636 dbSNP
rs1168471585 640 dbSNP
rs979924338 642 dbSNP
rs1046361451 644 dbSNP
rs1196129172 647 dbSNP
rs1472940294 653 dbSNP
rs1479297047 654 dbSNP
rs1266449717 655 dbSNP
rs570099501 657 dbSNP
rs905196830 658 dbSNP
rs1034848562 660 dbSNP
rs960086983 661 dbSNP
rs1032667754 663 dbSNP
rs1259527418 663 dbSNP
rs893764960 666 dbSNP
rs1310758808 668 dbSNP
rs533676266 670 dbSNP
rs1469158064 682 dbSNP
rs1334484023 685 dbSNP
rs1387826118 687 dbSNP
rs1370440615 694 dbSNP
rs1296505749 695 dbSNP
rs1360550008 697 dbSNP
rs918619646 705 dbSNP
rs929944049 706 dbSNP
rs1439504055 707 dbSNP
rs1173047567 724 dbSNP
rs1297137988 728 dbSNP
rs1376836859 741 dbSNP
rs1176581086 742 dbSNP
rs767110507 744 dbSNP
rs954433456 745 dbSNP
rs1457788068 751 dbSNP
rs777296069 771 dbSNP
rs1201359661 776 dbSNP
rs1017231031 780 dbSNP
rs910129639 787 dbSNP
rs537180758 788 dbSNP
rs576503809 801 dbSNP
rs900269534 821 dbSNP
rs555708472 822 dbSNP
rs1279714691 837 dbSNP
rs536102737 840 dbSNP
rs1051450205 845 dbSNP
rs1202742535 852 dbSNP
rs1303199068 857 dbSNP
rs1251329948 861 dbSNP
rs891499505 871 dbSNP
rs1009847586 874 dbSNP
rs1021967294 875 dbSNP
rs904399493 878 dbSNP
rs556085270 885 dbSNP
rs1422861755 892 dbSNP
rs1001792023 895 dbSNP
rs1256350640 900 dbSNP
rs1353841132 901 dbSNP
rs576297814 908 dbSNP
rs567366002 911 dbSNP
rs992935523 916 dbSNP
rs1216495172 917 dbSNP
rs1025731649 918 dbSNP
rs951393954 919 dbSNP
rs1053816715 935 dbSNP
rs1339962574 938 dbSNP
rs561891829 945 dbSNP
rs984106272 957 dbSNP
rs1398041023 958 dbSNP
rs1358364022 962 dbSNP
rs1297396425 969 dbSNP
rs527464906 978 dbSNP
rs910129055 981 dbSNP
rs942944265 985 dbSNP
rs142140191 987 dbSNP
rs976000857 995 dbSNP
rs890290762 1002 dbSNP
rs758776074 1008 dbSNP
rs1169374036 1012 dbSNP
rs922804686 1013 dbSNP
rs934144623 1014 dbSNP
rs1051492057 1020 dbSNP
rs1261444495 1022 dbSNP
rs181142432 1023 dbSNP
rs945716572 1025 dbSNP
rs1344190049 1026 dbSNP
rs1288713649 1031 dbSNP
rs1208587483 1040 dbSNP
rs994891336 1041 dbSNP
rs1436328287 1042 dbSNP
rs1027351510 1048 dbSNP
rs751774958 1056 dbSNP
rs1338799974 1065 dbSNP
rs1277313875 1068 dbSNP
rs952908877 1071 dbSNP
rs983047688 1077 dbSNP
rs1042703802 1081 dbSNP
rs532588385 1082 dbSNP
rs866290884 1086 dbSNP
rs1274273429 1087 dbSNP
rs1001488410 1088 dbSNP
rs1207396489 1090 dbSNP
rs970880200 1091 dbSNP
rs1056098323 1100 dbSNP
rs757377262 1109 dbSNP
rs552332620 1110 dbSNP
rs1170969367 1113 dbSNP
rs1478317094 1114 dbSNP
rs373501292 1116 dbSNP
rs1025743018 1117 dbSNP
rs951404860 1119 dbSNP
rs1451574982 1121 dbSNP
rs1248365342 1122 dbSNP
rs938139614 1126 dbSNP
rs1474339237 1129 dbSNP
rs1054168520 1130 dbSNP
rs1219512258 1136 dbSNP
rs1005986348 1137 dbSNP
rs1016908593 1142 dbSNP
rs964380430 1143 dbSNP
rs189869973 1150 dbSNP
rs945256654 1151 dbSNP
rs1389339900 1153 dbSNP
rs975716839 1159 dbSNP
rs922847201 1166 dbSNP
rs955543606 1167 dbSNP
rs1170902448 1170 dbSNP
rs878897099 1171 dbSNP
rs781203106 1173 dbSNP
rs1324846199 1174 dbSNP
rs988227589 1176 dbSNP
rs890405813 1180 dbSNP
rs912999784 1184 dbSNP
rs1009142657 1188 dbSNP
rs1038889939 1191 dbSNP
rs11129967 1192 dbSNP
rs1237668224 1206 dbSNP
rs1043183698 1207 dbSNP
rs1276240760 1209 dbSNP
rs994608671 1211 dbSNP
rs925665507 1214 dbSNP
rs1355796080 1218 dbSNP
rs1210499406 1219 dbSNP
rs1027297670 1224 dbSNP
rs369125479 1225 dbSNP
rs1055749481 1230 dbSNP
rs950364160 1242 dbSNP
rs534147134 1243 dbSNP
rs1292028520 1248 dbSNP
rs1004587121 1249 dbSNP
rs547539322 1253 dbSNP
rs895701971 1254 dbSNP
rs570222726 1266 dbSNP
rs771189236 1266 dbSNP
rs577918662 1273 dbSNP
rs1438869206 1274 dbSNP
rs1046908245 1291 dbSNP
rs1248360476 1295 dbSNP
rs1379737276 1296 dbSNP
rs1187323559 1317 dbSNP
rs887205745 1318 dbSNP
rs1005665372 1328 dbSNP
rs1471273393 1329 dbSNP
rs865913866 1333 dbSNP
rs1450980799 1337 dbSNP
rs545168783 1341 dbSNP
rs964118907 1342 dbSNP
rs539510083 1362 dbSNP
rs146404908 1363 dbSNP
rs1472878669 1366 dbSNP
rs1352980694 1367 dbSNP
rs1164419641 1378 dbSNP
rs1022496116 1380 dbSNP
rs1309333049 1380 dbSNP
rs955596697 1388 dbSNP
rs1376345004 1389 dbSNP
rs181088723 1390 dbSNP
rs914099601 1391 dbSNP
rs749101794 1395 dbSNP
rs868036935 1396 dbSNP
rs1437700360 1397 dbSNP
rs1335041877 1400 dbSNP
rs1418405191 1434 dbSNP
rs1360513356 1436 dbSNP
rs945371153 1437 dbSNP
rs535418000 1445 dbSNP
rs759840992 1445 dbSNP
rs1411764700 1446 dbSNP
rs768464738 1450 dbSNP
rs1259319198 1453 dbSNP
rs937030538 1466 dbSNP
rs747783292 1467 dbSNP
rs1286561034 1470 dbSNP
rs1217902750 1471 dbSNP
rs796558626 1476 dbSNP
rs1285970816 1482 dbSNP
rs1348484088 1483 dbSNP
rs1227670270 1493 dbSNP
rs1268657652 1495 dbSNP
rs1295488531 1499 dbSNP
rs1398478913 1503 dbSNP
rs1466132394 1505 dbSNP
rs900349404 1510 dbSNP
rs1299305928 1512 dbSNP
rs917190270 1513 dbSNP
rs1348183314 1515 dbSNP
rs1201530249 1521 dbSNP
rs1255053569 1528 dbSNP
rs1442580126 1537 dbSNP
rs139736873 1538 dbSNP
rs1047002103 1546 dbSNP
rs753643072 1552 dbSNP
rs1473900524 1559 dbSNP
rs1361514149 1561 dbSNP
rs1471958762 1575 dbSNP
rs886972892 1581 dbSNP
rs572340514 1582 dbSNP
rs541227276 1590 dbSNP
rs1413331953 1593 dbSNP
rs1038459385 1600 dbSNP
rs1221738606 1601 dbSNP
rs771738688 1610 dbSNP
rs1255690624 1615 dbSNP
rs1217672061 1620 dbSNP
rs560547364 1636 dbSNP
rs1317630362 1640 dbSNP
rs1296809515 1641 dbSNP
rs899873245 1644 dbSNP
rs1171121759 1645 dbSNP
rs1366200549 1646 dbSNP
rs772781689 1649 dbSNP
rs1396775520 1654 dbSNP
rs996874594 1655 dbSNP
rs1029587318 1665 dbSNP
rs1396817186 1667 dbSNP
rs1329497418 1671 dbSNP
rs1348753109 1674 dbSNP
rs1465346745 1688 dbSNP
rs186177120 1690 dbSNP
rs1009797207 1691 dbSNP
rs576072471 1694 dbSNP
rs968278824 1695 dbSNP
rs200439629 1699 dbSNP
rs562779850 1702 dbSNP
rs1469387744 1703 dbSNP
rs11706280 1704 dbSNP
rs1345313062 1716 dbSNP
rs989641668 1716 dbSNP
rs1252252187 1717 dbSNP
rs1032764875 1718 dbSNP
rs548152471 1732 dbSNP
rs3821837 1733 dbSNP
rs1373258705 1734 dbSNP
rs916950084 1739 dbSNP
rs1446317302 1740 dbSNP
rs527938659 1742 dbSNP
rs374848455 1743 dbSNP
rs1482477369 1746 dbSNP
rs949684038 1758 dbSNP
rs1464299597 1765 dbSNP
rs911908582 1772 dbSNP
rs1455573623 1773 dbSNP
rs1377918334 1774 dbSNP
rs763269071 1778 dbSNP
rs547626766 1781 dbSNP
rs369291583 1782 dbSNP
rs908449249 1784 dbSNP
rs1253175856 1790 dbSNP
rs1473827448 1794 dbSNP
rs1255819102 1797 dbSNP
rs1174428697 1798 dbSNP
rs1350766185 1799 dbSNP
rs941204228 1824 dbSNP
rs921725552 1826 dbSNP
rs1038585171 1829 dbSNP
rs930493399 1836 dbSNP
rs1309373241 1848 dbSNP
rs1048950822 1850 dbSNP
rs571021869 1851 dbSNP
rs932765186 1854 dbSNP
rs1051109106 1855 dbSNP
rs1045402417 1866 dbSNP
rs1436503442 1866 dbSNP
rs369632721 1866 dbSNP
rs553964552 1866 dbSNP
rs764497869 1867 dbSNP
rs373020228 1868 dbSNP
rs539187111 1869 dbSNP
rs1300462583 1870 dbSNP
rs1021215277 1871 dbSNP
rs549830497 1872 dbSNP
rs895426491 1873 dbSNP
rs1011011290 1877 dbSNP
rs1022447924 1885 dbSNP
rs569613719 1886 dbSNP
rs978163825 1887 dbSNP
rs1019321424 1891 dbSNP
rs1321422531 1893 dbSNP
rs1034235617 1894 dbSNP
rs535453254 1898 dbSNP
rs959556055 1900 dbSNP
rs761986480 1901 dbSNP
rs1293669471 1907 dbSNP
rs1416336873 1909 dbSNP
rs1024060433 1911 dbSNP
rs190499211 1913 dbSNP
rs966077632 1915 dbSNP
rs1190023030 1926 dbSNP
rs971087687 1930 dbSNP
rs1297447661 1939 dbSNP
rs975190162 1942 dbSNP
rs982403230 1943 dbSNP
rs1161017204 1953 dbSNP
rs1457082595 1956 dbSNP
rs1434182952 1960 dbSNP
rs1166654286 1962 dbSNP
rs1201374430 1963 dbSNP
rs908472446 1964 dbSNP
rs1261512746 1966 dbSNP
rs1193549190 1972 dbSNP
rs1448124359 1983 dbSNP
rs921855773 1984 dbSNP
rs572377285 1986 dbSNP
rs1488207688 1988 dbSNP
rs951972823 1992 dbSNP
rs962916763 1998 dbSNP
rs1169340581 2014 dbSNP
rs1372530778 2023 dbSNP
rs3733059 2024 dbSNP
rs67813463 2025 dbSNP
rs3733060 2026 dbSNP
rs932483001 2027 dbSNP
rs1051156651 2031 dbSNP
rs928408983 2032 dbSNP
rs1295057373 2035 dbSNP
rs1327443637 2040 dbSNP
rs577753630 2041 dbSNP
rs868800730 2048 dbSNP
rs1421898536 2049 dbSNP
rs756176426 2056 dbSNP
rs1319455321 2064 dbSNP
rs945382534 2067 dbSNP
rs541039180 2070 dbSNP
rs1375232186 2073 dbSNP
rs3733061 2078 dbSNP
rs563021383 2080 dbSNP
rs6785543 2087 dbSNP
rs748847280 2088 dbSNP
rs1001554598 2091 dbSNP
rs1043849065 2095 dbSNP
rs1212024999 2096 dbSNP
rs1246528274 2106 dbSNP
rs1257175130 2108 dbSNP
rs1196098723 2115 dbSNP
rs1341215967 2122 dbSNP
rs528342139 2138 dbSNP
rs754749105 2143 dbSNP
rs182975464 2163 dbSNP
rs1305045532 2164 dbSNP
rs1444122531 2168 dbSNP
rs778692610 2174 dbSNP
rs1399169856 2188 dbSNP
rs1329149212 2195 dbSNP
rs1013755646 2197 dbSNP
rs1422203115 2198 dbSNP
rs1024071656 2205 dbSNP
rs999529689 2217 dbSNP
rs1369001199 2226 dbSNP
rs1454251766 2228 dbSNP
rs1019018723 2231 dbSNP
rs971109781 2237 dbSNP
rs1003892269 2247 dbSNP
rs1318335290 2259 dbSNP
rs996181423 2260 dbSNP
rs528024013 2264 dbSNP
rs547663042 2265 dbSNP
rs1348588328 2268 dbSNP
rs551536072 2270 dbSNP
rs974435183 2286 dbSNP
rs1227253867 2288 dbSNP
rs1312746121 2289 dbSNP
rs1322881261 2292 dbSNP
rs61347556 2300 dbSNP
rs953887547 2301 dbSNP
rs1443983057 2303 dbSNP
rs1337867904 2317 dbSNP
rs1332680346 2322 dbSNP
rs1434626196 2333 dbSNP
rs1376532447 2336 dbSNP
rs986557514 2337 dbSNP
rs907676910 2339 dbSNP
rs1464774085 2341 dbSNP
rs1209743978 2344 dbSNP
rs961865455 2345 dbSNP
rs1482367380 2348 dbSNP
rs1159344982 2358 dbSNP
rs1471304258 2362 dbSNP
rs981722209 2365 dbSNP
rs1235519382 2370 dbSNP
rs1181377084 2377 dbSNP
rs928385342 2380 dbSNP
rs569777173 2382 dbSNP
rs1259449998 2391 dbSNP
rs945435117 2397 dbSNP
rs1042463591 2398 dbSNP
rs1352299225 2402 dbSNP
rs925301833 2405 dbSNP
rs1055435361 2412 dbSNP
rs1353889216 2422 dbSNP
rs569732751 2427 dbSNP
rs1356537786 2428 dbSNP
rs1043962056 2429 dbSNP
rs528953656 2431 dbSNP
rs1161032106 2444 dbSNP
rs895368239 2456 dbSNP
rs1344654945 2457 dbSNP
rs1013777048 2462 dbSNP
rs1357090791 2473 dbSNP
rs2290977 2477 dbSNP
rs1411828848 2479 dbSNP
rs1303030700 2482 dbSNP
rs747759440 2482 dbSNP
rs886591854 2485 dbSNP
rs901901362 2506 dbSNP
rs565659277 2509 dbSNP
rs1454376383 2512 dbSNP
rs1015340015 2514 dbSNP
rs1191372705 2516 dbSNP
rs1485539004 2517 dbSNP
rs1217233836 2520 dbSNP
rs1242175829 2520 dbSNP
rs1449379066 2524 dbSNP
rs1272100485 2525 dbSNP
rs1233547570 2531 dbSNP
rs1328998077 2532 dbSNP
rs148641473 2542 dbSNP
rs2290976 2543 dbSNP
rs1289984951 2546 dbSNP
rs9816776 2550 dbSNP
rs1325421162 2557 dbSNP
rs1462197250 2563 dbSNP
rs953940991 2567 dbSNP
rs1168342951 2570 dbSNP
rs986609961 2571 dbSNP
rs1420057316 2575 dbSNP
rs1019436457 2581 dbSNP
rs1476727359 2582 dbSNP
rs771790031 2583 dbSNP
rs1213897062 2585 dbSNP
rs978623184 2587 dbSNP
rs958458012 2588 dbSNP
rs1202798233 2590 dbSNP
rs991648579 2592 dbSNP
rs1296874757 2595 dbSNP
rs1216854697 2599 dbSNP
rs1251000997 2607 dbSNP
rs66933062 2629 dbSNP
rs947044845 2640 dbSNP
rs936677600 2645 dbSNP
rs1441895715 2651 dbSNP
rs990799394 2659 dbSNP
rs1178757440 2661 dbSNP
rs71323165 2668 dbSNP
rs1396885930 2674 dbSNP
rs1329564284 2678 dbSNP
rs1461258889 2679 dbSNP
rs977094161 2681 dbSNP
rs1422842207 2682 dbSNP
rs916845430 2682 dbSNP
rs1393952129 2687 dbSNP
rs1193783495 2689 dbSNP
rs1455204586 2690 dbSNP
rs527522425 2695 dbSNP
rs1040525869 2696 dbSNP
rs113773465 2696 dbSNP
rs1480485110 2698 dbSNP
rs1252311224 2711 dbSNP
rs548442775 2718 dbSNP
rs1176409291 2730 dbSNP
rs886645608 2732 dbSNP
rs932051659 2733 dbSNP
rs940860363 2741 dbSNP
rs1305072773 2745 dbSNP
rs1050492507 2747 dbSNP
rs1373750107 2754 dbSNP
rs541918442 2757 dbSNP
rs57179407 2777 dbSNP
rs1014961387 2780 dbSNP
rs763469866 2784 dbSNP
rs1377975481 2795 dbSNP
rs572090238 2796 dbSNP
rs889437642 2799 dbSNP
rs540991813 2800 dbSNP
rs1019488969 2808 dbSNP
rs564822648 2815 dbSNP
rs1179258060 2818 dbSNP
rs1350244788 2819 dbSNP
rs1257380715 2820 dbSNP
rs533410398 2822 dbSNP
rs966981254 2823 dbSNP
rs1259080946 2830 dbSNP
rs1238596686 2834 dbSNP
rs1317808964 2836 dbSNP
rs1273956731 2845 dbSNP
rs1309441916 2846 dbSNP
rs977919547 2850 dbSNP
rs1412629300 2859 dbSNP
rs534653014 2862 dbSNP
rs1354617715 2868 dbSNP
rs774713370 2871 dbSNP
rs958116869 2873 dbSNP
rs762041319 2874 dbSNP
rs760644710 2880 dbSNP
rs1382107356 2888 dbSNP
rs991370309 2894 dbSNP
rs916606611 2895 dbSNP
rs1453864446 2896 dbSNP
rs1365126123 2899 dbSNP
rs2290975 2904 dbSNP
rs1191485827 2909 dbSNP
rs1474409161 2910 dbSNP
rs865843349 2911 dbSNP
rs982393585 2916 dbSNP
rs1396519953 2918 dbSNP
rs563718976 2919 dbSNP
rs1259737946 2921 dbSNP
rs1204563629 2922 dbSNP
rs1252515706 2924 dbSNP
rs1262660242 2924 dbSNP
rs1231717158 2928 dbSNP
rs1447236090 2931 dbSNP
rs1167452051 2933 dbSNP
rs908090061 2941 dbSNP
rs546610806 2942 dbSNP
rs529029027 2943 dbSNP
rs549086583 2953 dbSNP
rs977028804 2964 dbSNP
rs1348644151 2972 dbSNP
rs760788743 2980 dbSNP
rs898257928 2981 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions Flp-In T-REx 293-hAGO1 cells
Location of target site 3'UTR
Original Description (Extracted from the article) ... Validation of interactions identified by CLASH suppports their reliability. ...

- Helwak A; Kudla G; Dudnakova T; Tollervey D, 2013, Cell.

Article - Helwak A; Kudla G; Dudnakova T; Tollervey D
- Cell, 2013
MicroRNAs (miRNAs) play key roles in gene regulation, but reliable bioinformatic or experimental identification of their targets remains difficult. To provide an unbiased view of human miRNA targets, we developed a technique for ligation and sequencing of miRNA-target RNA duplexes associated with human AGO1. Here, we report data sets of more than 18,000 high-confidence miRNA-mRNA interactions. The binding of most miRNAs includes the 5' seed region, but around 60% of seed interactions are noncanonical, containing bulged or mismatched nucleotides. Moreover, seed interactions are generally accompanied by specific, nonseed base pairing. 18% of miRNA-mRNA interactions involve the miRNA 3' end, with little evidence for 5' contacts, and some of these were functionally validated. Analyses of miRNA:mRNA base pairing showed that miRNA species systematically differ in their target RNA interactions, and strongly overrepresented motifs were found in the interaction sites of several miRNAs. We speculate that these affect the response of RISC to miRNA-target binding.
LinkOut: [PMID: 23622248]
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE32688 Pancreatic cancer -0.506 1.6e-3 -0.225 1.1e-1 32 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis -0.466 1.9e-2 -0.689 3.9e-4 20 Click to see details
GSE19536 Breast cancer -0.179 3.7e-2 -0.116 1.3e-1 100 Click to see details
GSE14794 Lymphoblastoid cells 0.18 4.5e-2 0.213 2.2e-2 90 Click to see details
GSE19350 CNS germ cell tumors 0.501 4.9e-2 0.441 7.6e-2 12 Click to see details
GSE35602 Colorectal cancer stromal tissue 0.338 4.9e-2 0.288 8.1e-2 25 Click to see details
GSE17306 Multiple myeloma -0.188 9.8e-2 -0.187 9.9e-2 49 Click to see details
GSE26953 Aortic valvular endothelial cells -0.261 1.1e-1 -0.218 1.5e-1 24 Click to see details
GSE42095 Differentiated embryonic stem cells -0.262 1.1e-1 -0.292 8.8e-2 23 Click to see details
GSE21849 B cell lymphoma -0.225 1.2e-1 0.023 4.5e-1 29 Click to see details
GSE38226 Liver fibrosis -0.262 1.3e-1 -0.307 8.8e-2 21 Click to see details
GSE19783 ER+ ER+ breast cancer -0.264 1.3e-1 -0.274 1.2e-1 20 Click to see details
GSE21687 Ependynoma primary tumors 0.115 1.8e-1 0.068 3.0e-1 64 Click to see details
GSE19783 ER- ER- breast cancer -0.103 1.8e-1 -0.089 2.2e-1 79 Click to see details
GSE28260 Renal cortex and medulla 0.236 2.2e-1 0.209 2.5e-1 13 Click to see details
GSE21032 Prostate cancer -0.075 2.5e-1 -0.065 2.8e-1 83 Click to see details
GSE28544 Breast cancer -0.141 2.6e-1 -0.086 3.4e-1 24 Click to see details
GSE27834 Pluripotent stem cells 0.126 3.2e-1 0.135 3.1e-1 16 Click to see details
GSE38974 Chronic obstructive pulmonary disease 0.067 3.8e-1 0.009 4.8e-1 25 Click to see details
GSE15076 Monocyte-derived dendritic cells -0.022 4.8e-1 0.150 3.5e-1 9 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
PCPG 0.999 0.01 1.000 0.5 3 Click to see details
ESCA 0.61 0.02 0.691 0.01 11 Click to see details
PAAD -0.887 0.06 -0.200 0.4 4 Click to see details
STAD 0.282 0.06 0.309 0.04 32 Click to see details
COAD 0.589 0.06 0.524 0.09 8 Click to see details
BRCA -0.167 0.06 -0.138 0.11 84 Click to see details
KIRP -0.236 0.1 -0.182 0.16 32 Click to see details
HNSC 0.178 0.13 0.150 0.17 42 Click to see details
LIHC -0.162 0.13 -0.162 0.13 49 Click to see details
LUAD 0.337 0.14 0.448 0.07 12 Click to see details
KICH 0.197 0.17 0.171 0.21 25 Click to see details
LUSC -0.151 0.18 -0.164 0.16 38 Click to see details
CHOL -0.281 0.23 -0.383 0.15 9 Click to see details
THCA -0.057 0.33 -0.091 0.25 59 Click to see details
BLCA -0.084 0.37 -0.036 0.44 18 Click to see details
CESC 0.378 0.38 0.500 0.33 3 Click to see details
UCEC 0.072 0.38 0.096 0.35 19 Click to see details
KIRC -0.026 0.42 0.023 0.43 68 Click to see details
PRAD -0.007 0.48 0.036 0.4 50 Click to see details
PRAD -0.007 0.48 0.036 0.4 50 Click to see details
PRAD -0.007 0.48 0.036 0.4 50 Click to see details
82 hsa-miR-28-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT000595 CDKN1A cyclin dependent kinase inhibitor 1A 4 1
MIRT006402 MPL MPL proto-oncogene, thrombopoietin receptor 3 1
MIRT006411 N4BP1 NEDD4 binding protein 1 1 1
MIRT006414 OTUB1 OTU deubiquitinase, ubiquitin aldehyde binding 1 1 1
MIRT006416 TEX261 testis expressed 261 1 1
MIRT006418 MAPK1 mitogen-activated protein kinase 1 1 1
MIRT006419 E2F6 E2F transcription factor 6 1 1
MIRT049989 ZCCHC3 zinc finger CCHC-type containing 3 1 1
MIRT049990 TPM4 tropomyosin 4 1 1
MIRT049991 TULP4 tubby like protein 4 1 1
MIRT049992 SNX1 sorting nexin 1 1 1
MIRT049993 IMPDH1 inosine monophosphate dehydrogenase 1 1 1
MIRT049994 AAAS aladin WD repeat nucleoporin 1 1
MIRT049995 CENPV centromere protein V 1 1
MIRT049996 NRN1 neuritin 1 1 1
MIRT049997 GEMIN4 gem nuclear organelle associated protein 4 1 1
MIRT049998 ZBTB47 zinc finger and BTB domain containing 47 1 1
MIRT049999 UNG uracil DNA glycosylase 1 1
MIRT050000 CNN3 calponin 3 1 1
MIRT050001 KLHL12 kelch like family member 12 1 1
MIRT050002 TLK1 tousled like kinase 1 1 1
MIRT050003 SREBF2 sterol regulatory element binding transcription factor 2 4 1
MIRT050004 RAB36 RAB36, member RAS oncogene family 1 1
MIRT050005 ZNF106 zinc finger protein 106 1 1
MIRT050006 SETD7 SET domain containing lysine methyltransferase 7 1 1
MIRT050007 DENND4B DENN domain containing 4B 1 1
MIRT050008 CS citrate synthase 1 1
MIRT050009 CD276 CD276 molecule 1 1
MIRT050010 TUFM Tu translation elongation factor, mitochondrial 1 1
MIRT050011 SMYD1 SET and MYND domain containing 1 2 5
MIRT050012 SIK1 salt inducible kinase 1 1 1
MIRT054748 MAD2L1 mitotic arrest deficient 2 like 1 3 1
MIRT054749 BAG1 BCL2 associated athanogene 1 3 1
MIRT054750 RAP1B RAP1B, member of RAS oncogene family 3 1
MIRT317835 CCND3 cyclin D3 2 2
MIRT367642 ARHGAP42 Rho GTPase activating protein 42 2 4
MIRT443876 DDTL D-dopachrome tautomerase like 2 2
MIRT447544 RNF165 ring finger protein 165 2 2
MIRT447611 PCYOX1 prenylcysteine oxidase 1 2 2
MIRT447838 CTIF cap binding complex dependent translation initiation factor 2 2
MIRT448193 FAM168A family with sequence similarity 168 member A 2 2
MIRT448713 KLHL11 kelch like family member 11 2 2
MIRT450179 KLF7 Kruppel like factor 7 2 2
MIRT450312 DRAXIN dorsal inhibitory axon guidance protein 2 2
MIRT460792 VPS37B VPS37B, ESCRT-I subunit 2 2
MIRT466332 THRA thyroid hormone receptor, alpha 2 2
MIRT467610 SLC7A5 solute carrier family 7 member 5 2 2
MIRT471609 PAQR5 progestin and adipoQ receptor family member 5 2 2
MIRT472144 NKIRAS2 NFKB inhibitor interacting Ras like 2 2 4
MIRT476588 G3BP1 G3BP stress granule assembly factor 1 2 4
MIRT486265 LINC00346 long intergenic non-protein coding RNA 346 2 4
MIRT486480 TSC22D1 TSC22 domain family member 1 2 2
MIRT487978 IQSEC2 IQ motif and Sec7 domain 2 2 2
MIRT489428 TUBB2A tubulin beta 2A class IIa 2 2
MIRT500781 TMED4 transmembrane p24 trafficking protein 4 2 6
MIRT501235 SEMA4C semaphorin 4C 2 6
MIRT511045 NRF1 nuclear respiratory factor 1 2 2
MIRT512837 IER3 immediate early response 3 2 2
MIRT513091 USP9X ubiquitin specific peptidase 9, X-linked 2 2
MIRT513543 PRDM2 PR/SET domain 2 2 4
MIRT532391 UMPS uridine monophosphate synthetase 2 2
MIRT535846 MSI2 musashi RNA binding protein 2 2 2
MIRT537892 EDA2R ectodysplasin A2 receptor 2 2
MIRT552769 YIPF6 Yip1 domain family member 6 2 2
MIRT553549 TMEM167A transmembrane protein 167A 2 4
MIRT557228 HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 2 2
MIRT566756 MORF4L1 mortality factor 4 like 1 2 2
MIRT567505 FOXJ3 forkhead box J3 2 2
MIRT568165 CCDC6 coiled-coil domain containing 6 2 2
MIRT570263 PRSS16 protease, serine 16 2 2
MIRT614727 TEAD3 TEA domain transcription factor 3 2 2
MIRT668894 CRISPLD2 cysteine rich secretory protein LCCL domain containing 2 2 2
MIRT691021 CRTC3 CREB regulated transcription coactivator 3 2 2
MIRT697421 ZFP91 ZFP91 zinc finger protein 2 2
MIRT711474 SRD5A1 steroid 5 alpha-reductase 1 2 2
MIRT720189 CMC4 C-X9-C motif containing 4 2 2
MIRT720622 PIANP PILR alpha associated neural protein 2 2
MIRT731420 IGF1 insulin like growth factor 1 3 1
MIRT732850 LINC00265 long intergenic non-protein coding RNA 265 3 0
MIRT732851 PCNA proliferating cell nuclear antigen 3 0
MIRT736342 FOXO1 forkhead box O1 3 0
MIRT755341 YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta 3 1
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-28 Formaldehyde NULL 712 Microarray Human lung epithelial cells (A549) 21147603 2011 down-regulated
miR-28 5-aza-2'-deoxycytidine (5-Aza-CdR) approved 451668 Microarray breast cancer HB2 22076154 2011 down-regulated
miR-28 5-aza-2'-deoxycytidine (5-Aza-CdR) approved 451668 Microarray breast cancer MDA-MB231 22076154 2011 down-regulated
miR-28 5-aza-2'-deoxycytidine (5-Aza-CdR) approved 451668 Microarray breast cancer SKBR3 22076154 2011 down-regulated
miR-28 Tamoxifen approved 2733526 Microarray rat liver 17343880 2007 down-regulated
miR-28 Tamoxifen approved 2733526 Quantitative real-time PCR rat liver 17343880 2007 down-regulated
miR-28 Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) NULL 8490 Microarray mouse brain 19270793 2009 up-regulated
miR-28 Dexamethasone approved 5743 Microarray primary rat thymocytes 20847043 2010 down-regulated
miR-28 Morphine approved 5288826 Quantitative real-time PCR HIV 21224041 2011 down-regulated
miR-28-5p Methamphetamine approved 10836 Quantitative real-time PCR CD4+ T cells 24434277 2014 up-regulated
miR-28-5p Trastuzumab approved NULL Microarray SKBR3 cells. 22384020 2012 up-regulated
miR-28-5p Vitamin D3 approved 5280795 Quantitative real-time PCR Plasma 22594500 2012 up-regulated
miR-28-5p Ginsenoside Rh2 NULL 119307 Microarray NSCLC cell line A549 23152132 2013 down-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-28 Cisplatin 5460033 NSC119875 approved resistant High Gastric Cancer cell line (BGC823)
hsa-mir-28 Paclitaxel 36314 NSC125973 approved resistant cell line (A2780)
hsa-mir-28 Cisplatin 5460033 NSC119875 approved resistant cell line (A2780)
hsa-mir-28 Cisplatin 5460033 NSC119875 approved sensitive cell line (BxPC3)
hsa-mir-28 Cisplatin 5460033 NSC119875 approved resistant cell line (BGC-823)
hsa-miR-28-5p 2-[[6-[[bis(carboxymethyl)amino]methyl]-4-[2-[4-(2-phenylethynyl)phenyl]ethynyl]pyridin-2-yl]methyl-(carboxymethyl)amino]acetic acid 369524 NSC641379 resistant
hsa-miR-28-5p 2-[3-hydroxy-4-(acetylamino)phenyl]benzothiazole 395431 NSC699969 resistant
hsa-miR-28-5p Kinetin riboside 3832 NSC120958 resistant
hsa-miR-28-5p Michicarcin NSC191959 resistant
hsa-miR-28-5p Doxorubicin 31703 NSC123127 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-28-5p Verapamil 2520 NSC272366 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-28-5p Doxorubicin 31703 NSC123127 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-28-5p Paclitaxel 36314 NSC125973 approved sensitive High Laryngeal Cancer cell line (Hep2)
hsa-miR-28-5p Gemcitabine 60750 NSC613327 approved resistant High Bladder Cancer cell line (RT4, J82,TCCSUP, UM-UC-3,RT112,CUBIII)
hsa-miR-28-5p Paclitaxel 36314 NSC125973 approved resistant High Breast Cancer tissue
hsa-miR-28-5p Epirubicin 41867 NSC256942 approved resistant High Breast Cancer tissue
hsa-miR-28-5p Doxorubicin 31703 NSC123127 approved sensitive High Hepatocellular Carcinoma tissue and cell line (HepG2)
hsa-miR-28-5p Taxane 9548828 sensitive High Prostate Cancer cell line (PC-3, PR200)
hsa-miR-28-5p Cisplatin 5460033 NSC119875 approved resistant High Non-Small Cell Lung Cancer cell line (A549)
hsa-miR-28-5p Platinum 23939 resistant High Ovarian Cancer tissue
hsa-miR-28-5p Cisplatin 5460033 NSC119875 approved sensitive Low Cervical Cancer tissue
hsa-miR-28-5p Paclitaxel 36314 NSC125973 approved sensitive High Non-Small Cell Lung Cancer cell line (A549)
hsa-miR-28-5p Temozolomide 5394 NSC362856 approved resistant cell line (U251)
hsa-miR-28-5p Vemurafenib 42611257 NSC761431 approved sensitive cell line (451Lu)
hsa-miR-28-5p Cisplatin 5460033 NSC119875 approved sensitive cell line
hsa-miR-28-5p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-28-5p Vemurafenib 42611257 NSC761431 approved sensitive cell line (LM17)
hsa-miR-28-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-28-5p Tamoxifen 2733525 NSC180973 approved resistant cell line (LCC2)
hsa-miR-28-5p Tamoxifen+Fulvestrant resistant cell line (LCC9)
hsa-miR-28-5p Cisplatin 5460033 NSC119875 approved resistant cell line (CP20)
hsa-miR-28-5p Cisplatin 5460033 NSC119875 approved resistant cell line (CIS)
hsa-miR-28-5p Testosterone+Exemestane resistant cell line (MCF-7)
hsa-miR-28-5p Testosterone+Letrozole resistant cell line (MCF-7)
hsa-miR-28-5p Osimertinib 71496458 NSC779217 approved sensitive cell line (H1975)
hsa-miR-28-5p Methotrexate 126941 NSC740 approved resistant cell line (HT29)
hsa-miR-28-5p Sunitinib 5329102 NSC750690 approved resistant tissue (CardA)
hsa-miR-28-5p Pegylated interferon alpha+Ribavirin sensitive tissue (chronic hepatitis C)
hsa-miR-28-5p Platinum 23939 resistant tissue (non-small cell lung cancer)
hsa-miR-28-5p Paclitaxel 36314 NSC125973 approved sensitive cell line (PC3PR70)
hsa-miR-28-5p Paclitaxel 36314 NSC125973 approved sensitive cell line (PC3PR200)
hsa-miR-28-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-28-5p Vemurafenib 42611257 NSC761431 approved sensitive cell line (LM16)
hsa-miR-28-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (H460)

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