miRTarBase - #MIRT050003


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pre-miRNA Information
pre-miRNA hsa-mir-28   
Genomic Coordinates chr3: 188688781 - 188688866
Synonyms MIRN28, hsa-mir-28, miR-28, MIR28
Description Homo sapiens miR-28 stem-loop
Comment None
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-28-5p
Sequence 14| AAGGAGCUCACAGUCUAUUGAG |35
Evidence Experimental
Experiments Cloned
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 2 3 + 188688795 29233923 MiREDiBase
A-to-I 5 3 + 188688798 29233923 MiREDiBase
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSN18185224 6 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1466099417 7 dbSNP
rs1333243027 9 dbSNP
rs1211406812 12 dbSNP
rs1380324091 13 dbSNP
rs1350747725 14 dbSNP
rs564264103 17 dbSNP
rs1315387654 18 dbSNP
rs1380847802 20 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol SREBF2   
Synonyms SREBP-2, SREBP2, bHLHd2
Description sterol regulatory element binding transcription factor 2
Transcript NM_004599   
Expression
Putative miRNA Targets on SREBF2
3'UTR of SREBF2
(miRNA target sites are highlighted)		 
>SREBF2|NM_004599|3'UTR
   1 CCACCAGGCTCAGCCCACCCCTCCACCTCTCTCTCGATTTCTCTCTCTCCCCCTCAGCATCTTCCCGCTGAGAGTGGTGG
  81 GGAAGAGCCTTGTCTTCTTAGCTGTCACCTGCCGAGGCTTCTGGGCCACTCAGGCCAGTGCACCCCTGGGCAGAGCCCCT
 161 TAAAGCTGCTGTCACTAGATGCCCATGGTCCAGGGCCTGGTGGGCGTGAGAGGATAGGTGGCAGGGCAGAAACTGGGCAG
 241 CCCTGACTTGATAGCAGCAGGGGGAGCTCCCAAGCTGCCAAGCCCCTGCCTCCAGCCTTCCTGAGTTTCTCTCTCCTGAA
 321 CCCTACTCTCTCCTTTTTGCTTCCTCAGTTTTTATCAGGCTTTCTCTGGGGGACAGCAGTCTCTGAGCACCAGGGAGCAG
 401 TTGCCCTCAGGCCTGTGCCCAGCATGCCCTCCCCTTTTTATACGAATGTTTTCTACCAGTGTGCTTGGGTTTGCCATGAT
 481 GCGAGGCTGAGTTGCTGTAGCGTCTTGATTCTCTCCCTGGGTCTGCGTTCCCTCCCCTGGGCCTGACTGAGCCTGCTCAT
 561 TGTTTTTCCCTTTATTACACAGGACAGCCAGGGGAGGAGGGGGGCCCAGCCCTGGGAGGCTGGTGGGAGGCAGGGGGCAG
 641 GCCTGCGGATGCATGAAATAATGTTGGCATTATTTTTTAATTTTTTAAAAAATAAATGGTATCTTATTTAATTGTCCTGT
 721 TCCTTCCCACTCCCCGCCTCCTAGGATGTTAGCCCAAGCTCAGGGTAGGCCCAGGGGGCTGGGAGAAATGAAGCCACCCA
 801 TGGGGACTGGGGACCAGGGGCCTTCAGCATGGCTTCTAGGTTCCCTCCTCCCCCTACCCCATCTCCTACCTCCACAGTAC
 881 AGACTGTCCCCAACTTAACAGTGGTTCAACTTAAACCATGTTTCAACTTTACAATTGGTCTGTTGGGGTATTAAATGAAT
 961 TTGTGACTTAGGATATTTTCATTTATGATGGGTTTATCAGGAAGTAACCCCATGGTAAGTTGAGGCATATCTGTATATAT
1041 TTAAACCTAATTAATTCTTGAGCTGAAAATAAATAAACCAGGATGGCAGGGACCAACCCCTAATCCCTCCCCAGCGGCAA
1121 GCCCCTCTTTTCAGAGTGGGCAGAGGGTTGCCTATGGTGGGCACTAGGAATGAGGTCCCCTGCCTCGATGCGGGTCCTAG
1201 GAGAAAAAGTCCTACTTTTCTGGGTCCCCAGGTGCAGCACCTCCCGGAGACTGTTTCTCCCATGGCCTCCTGAGTGATGG
1281 GCCCTGCCTCCCTGTGCCTCATCCTCAGGCTGGTTGGAGCAGAGGGTGGGCAGGAGCCCCAGCACAGACTGGGGGGTGCT
1361 CACAGCAGGGCCACCTTGATGCAGGCTGGAATGTTATCCCTGGGGTGTGCTTGGACCCCACCTGCTTTCTTTCTCTCCTG
1441 CCCCTCCCCTACTCTCACTGTAATTTATGGACCCTGCCCGCCTGCGTGTTGTGTGTATGTCCTGTGCCTTTTCTCACTAT
1521 TGTTTGGGTGTGGGAGGGGGTGGTTTTTCACTGAAAAGGGGGGTACACCTATAGCTTTCTTGATGTTCAATCAATCAGTC
1601 ACTGTGTCCCAGACATATTCAATAAACACAGATTGGTACCACCCAGCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' gaGUUAUCUGACACUCGAGGaa 5'
            ||: ||:  | |||||||  
Target 5' agCAGCAGG--GGGAGCTCCca 3'
 253 - 272 136.00 -16.40
2 
miRNA  3' gaguuaUCUGA--CACUCGAGGAa 5'
                || ||   ||||:|:|| 
Target 5' gcctccAGCCTTCCTGAGTTTCTc 3'
 288 - 311 122.00 -10.80
3 
miRNA  3' gaGUUAUCUGACACUCGAGGaa 5'
            ||: || || ||||| ||  
Target 5' gaCAGCAGTCTCTGAGCACCag 3'
 372 - 393 120.00 -13.60
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30100130 16 COSMIC
COSN30143276 34 COSMIC
COSN16313843 35 COSMIC
COSN30134778 36 COSMIC
COSN31532500 37 COSMIC
COSN28719057 49 COSMIC
COSN30718271 49 COSMIC
COSN26485583 295 COSMIC
COSN19728191 483 COSMIC
COSN8019297 503 COSMIC
COSN8010882 1351 COSMIC
COSN1262379 1395 COSMIC
COSN6423246 1545 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1398477143 2 dbSNP
rs780145640 6 dbSNP
rs1015769878 9 dbSNP
rs1436578331 10 dbSNP
rs1449240309 13 dbSNP
rs1235914671 14 dbSNP
rs1310980884 17 dbSNP
rs1367736106 18 dbSNP
rs1339698569 19 dbSNP
rs1442612709 21 dbSNP
rs1280382254 22 dbSNP
rs773795908 25 dbSNP
rs1238059623 26 dbSNP
rs763613865 27 dbSNP
rs764693514 27 dbSNP
rs774840666 27 dbSNP
rs751748331 28 dbSNP
rs755071057 29 dbSNP
rs1348663670 30 dbSNP
rs1213697233 32 dbSNP
rs1277088866 33 dbSNP
rs368111329 36 dbSNP
rs775329815 37 dbSNP
rs751975688 40 dbSNP
rs1437365178 42 dbSNP
rs530488446 44 dbSNP
rs1395223161 46 dbSNP
rs757637763 47 dbSNP
rs549107299 48 dbSNP
rs767655243 48 dbSNP
rs2157590 49 dbSNP
rs750615465 49 dbSNP
rs762059283 52 dbSNP
rs765568769 53 dbSNP
rs1363712331 54 dbSNP
rs536100755 56 dbSNP
rs1399211482 57 dbSNP
rs1334231600 66 dbSNP
rs1384768074 67 dbSNP
rs1453017764 68 dbSNP
rs1466499892 70 dbSNP
rs554493901 74 dbSNP
rs1175529470 79 dbSNP
rs2229442 85 dbSNP
rs1042348018 89 dbSNP
rs944357784 96 dbSNP
rs1374655370 107 dbSNP
rs768600501 109 dbSNP
rs1261499642 113 dbSNP
rs938691390 114 dbSNP
rs1255910500 115 dbSNP
rs1057123575 117 dbSNP
rs1207473039 121 dbSNP
rs1319346365 122 dbSNP
rs1258096687 127 dbSNP
rs1261433444 131 dbSNP
rs1344332981 135 dbSNP
rs894589210 139 dbSNP
rs1314615521 143 dbSNP
rs1013004182 144 dbSNP
rs1300983400 151 dbSNP
rs190471548 152 dbSNP
rs888627518 157 dbSNP
rs1004313794 161 dbSNP
rs557842072 172 dbSNP
rs1465306052 203 dbSNP
rs1462054196 205 dbSNP
rs576372173 206 dbSNP
rs183045818 207 dbSNP
rs998299982 213 dbSNP
rs1027991671 223 dbSNP
rs953809325 228 dbSNP
rs1410335988 238 dbSNP
rs989259900 243 dbSNP
rs555445974 249 dbSNP
rs914972725 250 dbSNP
rs1266827503 253 dbSNP
rs966560123 256 dbSNP
rs1320854913 258 dbSNP
rs147855211 260 dbSNP
rs1448925291 270 dbSNP
rs1377465874 271 dbSNP
rs1371872884 272 dbSNP
rs766874234 275 dbSNP
rs2269664 280 dbSNP
rs1344856169 282 dbSNP
rs1196752647 283 dbSNP
rs1275633754 284 dbSNP
rs1456708120 285 dbSNP
rs1197677755 290 dbSNP
rs1253196413 291 dbSNP
rs373831358 295 dbSNP
rs1349999429 298 dbSNP
rs1196058095 302 dbSNP
rs1377001080 306 dbSNP
rs1409083140 307 dbSNP
rs973938218 308 dbSNP
rs1475737338 309 dbSNP
rs1169564631 310 dbSNP
rs1239313986 312 dbSNP
rs1177525498 313 dbSNP
rs1456049612 314 dbSNP
rs1027483597 316 dbSNP
rs1464877101 317 dbSNP
rs1224120340 321 dbSNP
rs1330973611 321 dbSNP
rs559207582 322 dbSNP
rs527948964 323 dbSNP
rs1055410953 326 dbSNP
rs1354400589 328 dbSNP
rs1239568393 330 dbSNP
rs986007181 330 dbSNP
rs915919605 333 dbSNP
rs73431000 334 dbSNP
rs1228867358 335 dbSNP
rs1048491361 336 dbSNP
rs1316488138 344 dbSNP
rs1218352386 346 dbSNP
rs888511992 349 dbSNP
rs1273439157 355 dbSNP
rs944326516 361 dbSNP
rs1387578510 368 dbSNP
rs1390202565 376 dbSNP
rs1301754935 380 dbSNP
rs1198212799 382 dbSNP
rs987793823 385 dbSNP
rs1158535489 393 dbSNP
rs1438338339 398 dbSNP
rs913608418 402 dbSNP
rs1004366146 403 dbSNP
rs946478860 404 dbSNP
rs1432307751 406 dbSNP
rs1043873481 408 dbSNP
rs545303559 410 dbSNP
rs761955863 412 dbSNP
rs1037159200 414 dbSNP
rs563096286 416 dbSNP
rs749698407 417 dbSNP
rs1256613253 420 dbSNP
rs1481795264 421 dbSNP
rs901311669 422 dbSNP
rs1196917907 425 dbSNP
rs1267197124 426 dbSNP
rs904649881 433 dbSNP
rs1196730978 435 dbSNP
rs937522840 444 dbSNP
rs1055942571 445 dbSNP
rs187060938 446 dbSNP
rs1281584753 453 dbSNP
rs776360158 457 dbSNP
rs1402283234 458 dbSNP
rs896056392 459 dbSNP
rs1169451190 462 dbSNP
rs1014480484 468 dbSNP
rs538976123 483 dbSNP
rs879069027 484 dbSNP
rs897857388 492 dbSNP
rs549094855 503 dbSNP
rs1028158828 507 dbSNP
rs1477916769 508 dbSNP
rs953215635 510 dbSNP
rs1191154416 511 dbSNP
rs201578340 512 dbSNP
rs1010972511 516 dbSNP
rs1022084812 517 dbSNP
rs1344355979 523 dbSNP
rs1389995295 523 dbSNP
rs966440468 524 dbSNP
rs1403021752 525 dbSNP
rs1305075816 527 dbSNP
rs1018819294 528 dbSNP
rs1218276938 538 dbSNP
rs1429049244 538 dbSNP
rs1335417806 539 dbSNP
rs1293651374 542 dbSNP
rs1309639764 543 dbSNP
rs965933871 543 dbSNP
rs1172123683 548 dbSNP
rs977956858 550 dbSNP
rs1034850773 557 dbSNP
rs988091097 560 dbSNP
rs771257752 564 dbSNP
rs1166000260 573 dbSNP
rs191835473 580 dbSNP
rs1225332965 581 dbSNP
rs1186784375 586 dbSNP
rs1270477123 589 dbSNP
rs35684615 591 dbSNP
rs1440576199 592 dbSNP
rs1241370402 597 dbSNP
rs1490357791 599 dbSNP
rs529491681 601 dbSNP
rs990764890 603 dbSNP
rs916460165 604 dbSNP
rs948771613 616 dbSNP
rs984072449 617 dbSNP
rs1192483350 619 dbSNP
rs1358946233 622 dbSNP
rs568275502 622 dbSNP
rs8142691 636 dbSNP
rs773884942 637 dbSNP
rs926376982 640 dbSNP
rs940113350 646 dbSNP
rs377592698 647 dbSNP
rs4822067 648 dbSNP
rs752554908 649 dbSNP
rs917456661 650 dbSNP
rs1406696383 653 dbSNP
rs1414282470 654 dbSNP
rs17848343 663 dbSNP
rs1050036645 664 dbSNP
rs1180646536 666 dbSNP
rs374265319 669 dbSNP
rs556610610 669 dbSNP
rs182758758 670 dbSNP
rs1453486149 679 dbSNP
rs1291045154 681 dbSNP
rs537096033 687 dbSNP
rs1357997001 688 dbSNP
rs1312068122 700 dbSNP
rs1240291890 706 dbSNP
rs770295343 708 dbSNP
rs1399409943 717 dbSNP
rs760653568 727 dbSNP
rs1350038680 730 dbSNP
rs187681619 733 dbSNP
rs573830551 736 dbSNP
rs1018781676 737 dbSNP
rs1364426186 739 dbSNP
rs1159216684 743 dbSNP
rs1438954494 745 dbSNP
rs1034736893 755 dbSNP
rs534488155 760 dbSNP
rs1489952709 779 dbSNP
rs552857851 779 dbSNP
rs1357718823 783 dbSNP
rs6002530 801 dbSNP
rs34177566 802 dbSNP
rs868040927 805 dbSNP
rs544925994 810 dbSNP
rs1353540240 811 dbSNP
rs959111046 815 dbSNP
rs1214524424 819 dbSNP
rs984633637 820 dbSNP
rs1486664918 821 dbSNP
rs909894156 826 dbSNP
rs1255243038 827 dbSNP
rs1402679705 830 dbSNP
rs939997264 838 dbSNP
rs1442504512 847 dbSNP
rs563645462 849 dbSNP
rs922661648 850 dbSNP
rs761527639 852 dbSNP
rs1050343312 870 dbSNP
rs1416219701 877 dbSNP
rs1426187805 878 dbSNP
rs1199007831 884 dbSNP
rs575299845 886 dbSNP
rs1170412422 890 dbSNP
rs1347011764 891 dbSNP
rs1265807048 892 dbSNP
rs890082020 894 dbSNP
rs1259467737 896 dbSNP
rs946959047 899 dbSNP
rs1211672253 904 dbSNP
rs142525699 907 dbSNP
rs1381039865 911 dbSNP
rs902192344 916 dbSNP
rs1454859306 931 dbSNP
rs765069002 935 dbSNP
rs930939795 937 dbSNP
rs1359838870 938 dbSNP
rs1304481799 941 dbSNP
rs1448616432 949 dbSNP
rs1222532583 966 dbSNP
rs1468432284 967 dbSNP
rs1281583185 968 dbSNP
rs1426040828 968 dbSNP
rs1171900454 976 dbSNP
rs193248272 995 dbSNP
rs1132781 1001 dbSNP
rs896211524 1002 dbSNP
rs1012115528 1005 dbSNP
rs1483834194 1010 dbSNP
rs370768985 1013 dbSNP
rs1201227524 1015 dbSNP
rs1319631986 1018 dbSNP
rs1258275898 1019 dbSNP
rs1226473156 1021 dbSNP
rs1023893042 1025 dbSNP
rs1228826981 1028 dbSNP
rs1314548859 1028 dbSNP
rs1185257681 1034 dbSNP
rs879394551 1036 dbSNP
rs1006109223 1041 dbSNP
rs1450522237 1047 dbSNP
rs1175394205 1048 dbSNP
rs1402783689 1056 dbSNP
rs1014771928 1058 dbSNP
rs961384154 1063 dbSNP
rs558614662 1067 dbSNP
rs150953689 1075 dbSNP
rs901652467 1092 dbSNP
rs1175638784 1101 dbSNP
rs922747718 1114 dbSNP
rs185707836 1115 dbSNP
rs1009414570 1116 dbSNP
rs543861702 1117 dbSNP
rs1399995028 1127 dbSNP
rs9623473 1135 dbSNP
rs911384706 1142 dbSNP
rs1440676455 1143 dbSNP
rs1266996487 1154 dbSNP
rs781474748 1155 dbSNP
rs1358712522 1164 dbSNP
rs1044018595 1173 dbSNP
rs924170027 1180 dbSNP
rs533578298 1182 dbSNP
rs935011718 1183 dbSNP
rs1391044060 1187 dbSNP
rs1056525658 1188 dbSNP
rs369659648 1192 dbSNP
rs991833450 1193 dbSNP
rs1205168202 1203 dbSNP
rs1012417506 1213 dbSNP
rs971509750 1215 dbSNP
rs1044791460 1216 dbSNP
rs1380386410 1225 dbSNP
rs1436951417 1226 dbSNP
rs1202356151 1236 dbSNP
rs887627183 1241 dbSNP
rs34322574 1243 dbSNP
rs1005991782 1246 dbSNP
rs8988 1247 dbSNP
rs919458523 1249 dbSNP
rs1218723835 1252 dbSNP
rs574419142 1252 dbSNP
rs751123408 1252 dbSNP
rs994170680 1253 dbSNP
rs1261460983 1254 dbSNP
rs985066521 1254 dbSNP
rs910515091 1256 dbSNP
rs548995136 1257 dbSNP
rs1030081249 1265 dbSNP
rs1303643113 1271 dbSNP
rs1405732596 1271 dbSNP
rs955365553 1275 dbSNP
rs1481576318 1289 dbSNP
rs1386308203 1292 dbSNP
rs59344209 1295 dbSNP
rs1379045718 1303 dbSNP
rs1423362225 1304 dbSNP
rs1479873492 1308 dbSNP
rs1266515708 1312 dbSNP
rs1195569658 1315 dbSNP
rs1040453049 1325 dbSNP
rs1331486666 1341 dbSNP
rs1204674259 1343 dbSNP
rs901912688 1349 dbSNP
rs1224365749 1351 dbSNP
rs1355677029 1351 dbSNP
rs534753498 1351 dbSNP
rs911285448 1352 dbSNP
rs1402226857 1354 dbSNP
rs150114731 1357 dbSNP
rs1318210546 1360 dbSNP
rs756914675 1362 dbSNP
rs979581787 1369 dbSNP
rs1380977852 1375 dbSNP
rs1403738239 1379 dbSNP
rs924223824 1380 dbSNP
rs1224977102 1385 dbSNP
rs1426758538 1387 dbSNP
rs935566599 1388 dbSNP
rs868390297 1398 dbSNP
rs894793069 1411 dbSNP
rs1056684736 1418 dbSNP
rs1013220264 1420 dbSNP
rs917587052 1429 dbSNP
rs756219848 1432 dbSNP
rs554966485 1434 dbSNP
rs1045241264 1436 dbSNP
rs961094243 1445 dbSNP
rs1461083902 1448 dbSNP
rs972549647 1450 dbSNP
rs1026891213 1452 dbSNP
rs1220889284 1453 dbSNP
rs887516657 1456 dbSNP
rs952247900 1457 dbSNP
rs941903463 1467 dbSNP
rs1225886820 1472 dbSNP
rs113192727 1477 dbSNP
rs1036153968 1479 dbSNP
rs778425404 1480 dbSNP
rs539239553 1481 dbSNP
rs976060855 1482 dbSNP
rs562507436 1485 dbSNP
rs781017106 1486 dbSNP
rs189366177 1487 dbSNP
rs1165867378 1490 dbSNP
rs751756966 1490 dbSNP
rs575634891 1492 dbSNP
rs1042486964 1494 dbSNP
rs1162157543 1496 dbSNP
rs557901460 1498 dbSNP
rs1006871883 1502 dbSNP
rs745571929 1509 dbSNP
rs1406199278 1518 dbSNP
rs1194424630 1529 dbSNP
rs1359139889 1533 dbSNP
rs146594578 1537 dbSNP
rs1245835248 1539 dbSNP
rs895054658 1542 dbSNP
rs1325533995 1544 dbSNP
rs1013479751 1554 dbSNP
rs1428213965 1560 dbSNP
rs191901012 1562 dbSNP
rs1353552575 1567 dbSNP
rs1326669166 1570 dbSNP
rs1406854743 1571 dbSNP
rs1046045230 1572 dbSNP
rs1271776314 1582 dbSNP
rs572889068 1583 dbSNP
rs1366156901 1587 dbSNP
rs1442647211 1587 dbSNP
rs16443 1587 dbSNP
rs71864705 1587 dbSNP
rs200920748 1589 dbSNP
rs1383468050 1591 dbSNP
rs1245158046 1595 dbSNP
rs1470668699 1601 dbSNP
rs1289456432 1603 dbSNP
rs994282761 1610 dbSNP
rs539903164 1616 dbSNP
rs1361709769 1619 dbSNP
rs771253569 1623 dbSNP
rs1292902754 1628 dbSNP
rs1222422023 1631 dbSNP
rs1031177429 1637 dbSNP
rs1261089715 1640 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions Flp-In T-REx 293-hAGO1 cells
Location of target site CDS
Original Description (Extracted from the article) ... Validation of interactions identified by CLASH suppports their reliability. ...

- Helwak A; Kudla G; Dudnakova T; Tollervey D, 2013, Cell.

Article - Helwak A; Kudla G; Dudnakova T; Tollervey D
- Cell, 2013
MicroRNAs (miRNAs) play key roles in gene regulation, but reliable bioinformatic or experimental identification of their targets remains difficult. To provide an unbiased view of human miRNA targets, we developed a technique for ligation and sequencing of miRNA-target RNA duplexes associated with human AGO1. Here, we report data sets of more than 18,000 high-confidence miRNA-mRNA interactions. The binding of most miRNAs includes the 5' seed region, but around 60% of seed interactions are noncanonical, containing bulged or mismatched nucleotides. Moreover, seed interactions are generally accompanied by specific, nonseed base pairing. 18% of miRNA-mRNA interactions involve the miRNA 3' end, with little evidence for 5' contacts, and some of these were functionally validated. Analyses of miRNA:mRNA base pairing showed that miRNA species systematically differ in their target RNA interactions, and strongly overrepresented motifs were found in the interaction sites of several miRNAs. We speculate that these affect the response of RISC to miRNA-target binding.
LinkOut: [PMID: 23622248]
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE19536 Breast cancer 0.24 8.1e-3 0.273 3.0e-3 100 Click to see details
GSE19783 ER- ER- breast cancer 0.252 1.3e-2 0.295 4.2e-3 79 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis -0.363 5.8e-2 -0.725 1.5e-4 20 Click to see details
GSE27834 Pluripotent stem cells 0.387 6.9e-2 0.356 8.8e-2 16 Click to see details
GSE42095 Differentiated embryonic stem cells -0.243 1.3e-1 -0.233 1.4e-1 23 Click to see details
GSE35602 Colorectal cancer stromal tissue 0.223 1.4e-1 0.183 1.9e-1 25 Click to see details
GSE17498 Multiple myeloma 0.153 1.7e-1 0.188 1.2e-1 40 Click to see details
GSE19783 ER+ ER+ breast cancer 0.21 1.9e-1 0.185 2.2e-1 20 Click to see details
GSE19350 CNS germ cell tumors 0.27 2.0e-1 0.266 2.0e-1 12 Click to see details
GSE26953 Aortic valvular endothelial cells -0.178 2.0e-1 -0.205 1.7e-1 24 Click to see details
GSE28544 Breast cancer 0.176 2.1e-1 0.250 1.2e-1 24 Click to see details
GSE15076 Monocyte-derived dendritic cells 0.271 2.4e-1 -0.117 3.8e-1 9 Click to see details
GSE38974 Chronic obstructive pulmonary disease -0.143 2.5e-1 -0.150 2.4e-1 25 Click to see details
GSE28260 Renal cortex and medulla -0.192 2.6e-1 -0.137 3.3e-1 13 Click to see details
GSE21032 Prostate cancer -0.063 2.9e-1 0.049 3.3e-1 83 Click to see details
GSE21687 Ependynoma primary tumors -0.067 3.0e-1 -0.083 2.6e-1 64 Click to see details
GSE17306 Multiple myeloma -0.057 3.5e-1 -0.066 3.3e-1 49 Click to see details
GSE14794 Lymphoblastoid cells -0.025 4.1e-1 -0.157 7.0e-2 90 Click to see details
GSE21849 B cell lymphoma 0.035 4.3e-1 0.065 3.7e-1 29 Click to see details
GSE38226 Liver fibrosis -0.037 4.4e-1 0.291 1.0e-1 21 Click to see details
GSE32688 Pancreatic cancer 0.013 4.7e-1 -0.009 4.8e-1 32 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
KIRC -0.37 0 -0.344 0 68 Click to see details
LUSC 0.434 0 0.520 0 38 Click to see details
BLCA -0.517 0.01 -0.391 0.05 18 Click to see details
PCPG 0.999 0.01 1.000 0.5 3 Click to see details
KIRP -0.319 0.04 -0.274 0.06 32 Click to see details
CHOL -0.614 0.04 -0.133 0.37 9 Click to see details
PRAD 0.209 0.07 0.187 0.1 50 Click to see details
LIHC 0.206 0.08 0.272 0.03 49 Click to see details
THCA 0.163 0.11 0.180 0.09 59 Click to see details
BRCA 0.129 0.12 0.083 0.23 84 Click to see details
HNSC 0.179 0.13 0.269 0.04 42 Click to see details
CESC -0.852 0.18 -0.500 0.33 3 Click to see details
STAD 0.138 0.23 0.212 0.12 32 Click to see details
UCEC -0.153 0.27 -0.242 0.16 19 Click to see details
ESCA 0.211 0.27 -0.055 0.44 11 Click to see details
PAAD 0.395 0.3 -0.200 0.4 4 Click to see details
KICH 0.09 0.33 0.065 0.38 25 Click to see details
COAD 0.094 0.41 0.119 0.39 8 Click to see details
LUAD -0.044 0.45 -0.035 0.46 12 Click to see details
LUAD -0.044 0.45 -0.035 0.46 12 Click to see details
LUAD -0.044 0.45 -0.035 0.46 12 Click to see details
82 hsa-miR-28-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT000595 CDKN1A cyclin dependent kinase inhibitor 1A 4 1
MIRT006402 MPL MPL proto-oncogene, thrombopoietin receptor 3 1
MIRT006411 N4BP1 NEDD4 binding protein 1 1 1
MIRT006414 OTUB1 OTU deubiquitinase, ubiquitin aldehyde binding 1 1 1
MIRT006416 TEX261 testis expressed 261 1 1
MIRT006418 MAPK1 mitogen-activated protein kinase 1 1 1
MIRT006419 E2F6 E2F transcription factor 6 1 1
MIRT049989 ZCCHC3 zinc finger CCHC-type containing 3 1 1
MIRT049990 TPM4 tropomyosin 4 1 1
MIRT049991 TULP4 tubby like protein 4 1 1
MIRT049992 SNX1 sorting nexin 1 1 1
MIRT049993 IMPDH1 inosine monophosphate dehydrogenase 1 1 1
MIRT049994 AAAS aladin WD repeat nucleoporin 1 1
MIRT049995 CENPV centromere protein V 1 1
MIRT049996 NRN1 neuritin 1 1 1
MIRT049997 GEMIN4 gem nuclear organelle associated protein 4 1 1
MIRT049998 ZBTB47 zinc finger and BTB domain containing 47 1 1
MIRT049999 UNG uracil DNA glycosylase 1 1
MIRT050000 CNN3 calponin 3 1 1
MIRT050001 KLHL12 kelch like family member 12 1 1
MIRT050002 TLK1 tousled like kinase 1 1 1
MIRT050003 SREBF2 sterol regulatory element binding transcription factor 2 4 1
MIRT050004 RAB36 RAB36, member RAS oncogene family 1 1
MIRT050005 ZNF106 zinc finger protein 106 1 1
MIRT050006 SETD7 SET domain containing lysine methyltransferase 7 1 1
MIRT050007 DENND4B DENN domain containing 4B 1 1
MIRT050008 CS citrate synthase 1 1
MIRT050009 CD276 CD276 molecule 1 1
MIRT050010 TUFM Tu translation elongation factor, mitochondrial 1 1
MIRT050011 SMYD1 SET and MYND domain containing 1 2 5
MIRT050012 SIK1 salt inducible kinase 1 1 1
MIRT054748 MAD2L1 mitotic arrest deficient 2 like 1 3 1
MIRT054749 BAG1 BCL2 associated athanogene 1 3 1
MIRT054750 RAP1B RAP1B, member of RAS oncogene family 3 1
MIRT317835 CCND3 cyclin D3 2 2
MIRT367642 ARHGAP42 Rho GTPase activating protein 42 2 4
MIRT443876 DDTL D-dopachrome tautomerase like 2 2
MIRT447544 RNF165 ring finger protein 165 2 2
MIRT447611 PCYOX1 prenylcysteine oxidase 1 2 2
MIRT447838 CTIF cap binding complex dependent translation initiation factor 2 2
MIRT448193 FAM168A family with sequence similarity 168 member A 2 2
MIRT448713 KLHL11 kelch like family member 11 2 2
MIRT450179 KLF7 Kruppel like factor 7 2 2
MIRT450312 DRAXIN dorsal inhibitory axon guidance protein 2 2
MIRT460792 VPS37B VPS37B, ESCRT-I subunit 2 2
MIRT466332 THRA thyroid hormone receptor, alpha 2 2
MIRT467610 SLC7A5 solute carrier family 7 member 5 2 2
MIRT471609 PAQR5 progestin and adipoQ receptor family member 5 2 2
MIRT472144 NKIRAS2 NFKB inhibitor interacting Ras like 2 2 4
MIRT476588 G3BP1 G3BP stress granule assembly factor 1 2 4
MIRT486265 LINC00346 long intergenic non-protein coding RNA 346 2 4
MIRT486480 TSC22D1 TSC22 domain family member 1 2 2
MIRT487978 IQSEC2 IQ motif and Sec7 domain 2 2 2
MIRT489428 TUBB2A tubulin beta 2A class IIa 2 2
MIRT500781 TMED4 transmembrane p24 trafficking protein 4 2 6
MIRT501235 SEMA4C semaphorin 4C 2 6
MIRT511045 NRF1 nuclear respiratory factor 1 2 2
MIRT512837 IER3 immediate early response 3 2 2
MIRT513091 USP9X ubiquitin specific peptidase 9, X-linked 2 2
MIRT513543 PRDM2 PR/SET domain 2 2 4
MIRT532391 UMPS uridine monophosphate synthetase 2 2
MIRT535846 MSI2 musashi RNA binding protein 2 2 2
MIRT537892 EDA2R ectodysplasin A2 receptor 2 2
MIRT552769 YIPF6 Yip1 domain family member 6 2 2
MIRT553549 TMEM167A transmembrane protein 167A 2 4
MIRT557228 HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 2 2
MIRT566756 MORF4L1 mortality factor 4 like 1 2 2
MIRT567505 FOXJ3 forkhead box J3 2 2
MIRT568165 CCDC6 coiled-coil domain containing 6 2 2
MIRT570263 PRSS16 protease, serine 16 2 2
MIRT614727 TEAD3 TEA domain transcription factor 3 2 2
MIRT668894 CRISPLD2 cysteine rich secretory protein LCCL domain containing 2 2 2
MIRT691021 CRTC3 CREB regulated transcription coactivator 3 2 2
MIRT697421 ZFP91 ZFP91 zinc finger protein 2 2
MIRT711474 SRD5A1 steroid 5 alpha-reductase 1 2 2
MIRT720189 CMC4 C-X9-C motif containing 4 2 2
MIRT720622 PIANP PILR alpha associated neural protein 2 2
MIRT731420 IGF1 insulin like growth factor 1 3 1
MIRT732850 LINC00265 long intergenic non-protein coding RNA 265 3 0
MIRT732851 PCNA proliferating cell nuclear antigen 3 0
MIRT736342 FOXO1 forkhead box O1 3 0
MIRT755341 YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta 3 1
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-28 Formaldehyde NULL 712 Microarray Human lung epithelial cells (A549) 21147603 2011 down-regulated
miR-28 5-aza-2'-deoxycytidine (5-Aza-CdR) approved 451668 Microarray breast cancer HB2 22076154 2011 down-regulated
miR-28 5-aza-2'-deoxycytidine (5-Aza-CdR) approved 451668 Microarray breast cancer MDA-MB231 22076154 2011 down-regulated
miR-28 5-aza-2'-deoxycytidine (5-Aza-CdR) approved 451668 Microarray breast cancer SKBR3 22076154 2011 down-regulated
miR-28 Tamoxifen approved 2733526 Microarray rat liver 17343880 2007 down-regulated
miR-28 Tamoxifen approved 2733526 Quantitative real-time PCR rat liver 17343880 2007 down-regulated
miR-28 Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) NULL 8490 Microarray mouse brain 19270793 2009 up-regulated
miR-28 Dexamethasone approved 5743 Microarray primary rat thymocytes 20847043 2010 down-regulated
miR-28 Morphine approved 5288826 Quantitative real-time PCR HIV 21224041 2011 down-regulated
miR-28-5p Methamphetamine approved 10836 Quantitative real-time PCR CD4+ T cells 24434277 2014 up-regulated
miR-28-5p Trastuzumab approved NULL Microarray SKBR3 cells. 22384020 2012 up-regulated
miR-28-5p Vitamin D3 approved 5280795 Quantitative real-time PCR Plasma 22594500 2012 up-regulated
miR-28-5p Ginsenoside Rh2 NULL 119307 Microarray NSCLC cell line A549 23152132 2013 down-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-28 Cisplatin 5460033 NSC119875 approved resistant High Gastric Cancer cell line (BGC823)
hsa-mir-28 Paclitaxel 36314 NSC125973 approved resistant cell line (A2780)
hsa-mir-28 Cisplatin 5460033 NSC119875 approved resistant cell line (A2780)
hsa-mir-28 Cisplatin 5460033 NSC119875 approved sensitive cell line (BxPC3)
hsa-mir-28 Cisplatin 5460033 NSC119875 approved resistant cell line (BGC-823)
hsa-miR-28-5p 2-[[6-[[bis(carboxymethyl)amino]methyl]-4-[2-[4-(2-phenylethynyl)phenyl]ethynyl]pyridin-2-yl]methyl-(carboxymethyl)amino]acetic acid 369524 NSC641379 resistant
hsa-miR-28-5p 2-[3-hydroxy-4-(acetylamino)phenyl]benzothiazole 395431 NSC699969 resistant
hsa-miR-28-5p Kinetin riboside 3832 NSC120958 resistant
hsa-miR-28-5p Michicarcin NSC191959 resistant
hsa-miR-28-5p Doxorubicin 31703 NSC123127 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-28-5p Verapamil 2520 NSC272366 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-28-5p Doxorubicin 31703 NSC123127 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-28-5p Paclitaxel 36314 NSC125973 approved sensitive High Laryngeal Cancer cell line (Hep2)
hsa-miR-28-5p Gemcitabine 60750 NSC613327 approved resistant High Bladder Cancer cell line (RT4, J82,TCCSUP, UM-UC-3,RT112,CUBIII)
hsa-miR-28-5p Paclitaxel 36314 NSC125973 approved resistant High Breast Cancer tissue
hsa-miR-28-5p Epirubicin 41867 NSC256942 approved resistant High Breast Cancer tissue
hsa-miR-28-5p Doxorubicin 31703 NSC123127 approved sensitive High Hepatocellular Carcinoma tissue and cell line (HepG2)
hsa-miR-28-5p Taxane 9548828 sensitive High Prostate Cancer cell line (PC-3, PR200)
hsa-miR-28-5p Cisplatin 5460033 NSC119875 approved resistant High Non-Small Cell Lung Cancer cell line (A549)
hsa-miR-28-5p Platinum 23939 resistant High Ovarian Cancer tissue
hsa-miR-28-5p Cisplatin 5460033 NSC119875 approved sensitive Low Cervical Cancer tissue
hsa-miR-28-5p Paclitaxel 36314 NSC125973 approved sensitive High Non-Small Cell Lung Cancer cell line (A549)
hsa-miR-28-5p Temozolomide 5394 NSC362856 approved resistant cell line (U251)
hsa-miR-28-5p Vemurafenib 42611257 NSC761431 approved sensitive cell line (451Lu)
hsa-miR-28-5p Cisplatin 5460033 NSC119875 approved sensitive cell line
hsa-miR-28-5p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-28-5p Vemurafenib 42611257 NSC761431 approved sensitive cell line (LM17)
hsa-miR-28-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-28-5p Tamoxifen 2733525 NSC180973 approved resistant cell line (LCC2)
hsa-miR-28-5p Tamoxifen+Fulvestrant resistant cell line (LCC9)
hsa-miR-28-5p Cisplatin 5460033 NSC119875 approved resistant cell line (CP20)
hsa-miR-28-5p Cisplatin 5460033 NSC119875 approved resistant cell line (CIS)
hsa-miR-28-5p Testosterone+Exemestane resistant cell line (MCF-7)
hsa-miR-28-5p Testosterone+Letrozole resistant cell line (MCF-7)
hsa-miR-28-5p Osimertinib 71496458 NSC779217 approved sensitive cell line (H1975)
hsa-miR-28-5p Methotrexate 126941 NSC740 approved resistant cell line (HT29)
hsa-miR-28-5p Sunitinib 5329102 NSC750690 approved resistant tissue (CardA)
hsa-miR-28-5p Pegylated interferon alpha+Ribavirin sensitive tissue (chronic hepatitis C)
hsa-miR-28-5p Platinum 23939 resistant tissue (non-small cell lung cancer)
hsa-miR-28-5p Paclitaxel 36314 NSC125973 approved sensitive cell line (PC3PR70)
hsa-miR-28-5p Paclitaxel 36314 NSC125973 approved sensitive cell line (PC3PR200)
hsa-miR-28-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-28-5p Vemurafenib 42611257 NSC761431 approved sensitive cell line (LM16)
hsa-miR-28-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (H460)

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