miRTarBase - #MIRT052825


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pre-miRNA Information
pre-miRNA hsa-mir-3200   
Genomic Coordinates chr22: 30731557 - 30731641
Description Homo sapiens miR-3200 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-3200-3p
Sequence 54| CACCUUGCGCUACUCAGGUCUG |75
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1354947096 9 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol PPIA   
Synonyms CYPA, CYPH, HEL-S-69p
Description peptidylprolyl isomerase A
Transcript NM_021130   
Expression
Putative miRNA Targets on PPIA
3'UTR of PPIA
(miRNA target sites are highlighted)		 
>PPIA|NM_021130|3'UTR
   1 GTTTGACTTGTGTTTTATCTTAACCACCAGATCATTCCTTCTGTAGCTCAGGAGAGCACCCCTCCACCCCATTTGCTCGC
  81 AGTATCCTAGAATCTTTGTGCTCTCGCTGCAGTTCCCTTTGGGTTCCATGTTTTCCTTGTTCCCTCCCATGCCTAGCTGG
 161 ATTGCAGAGTTAAGTTTATGATTATGAAATAAAAACTAAATAACAATTGTCCTCGTTTGAGTTAAGAGTGTTGATGTAGG
 241 CTTTATTTTAAGCAGTAATGGGTTACTTCTGAAACATCACTTGTTTGCTTAATTCTACACAGTACTTAGATTTTTTTTAC
 321 TTTCCAGTCCCAGGAAGTGTCAATGTTTGTTGAGTGGAATATTGAAAATGTAGGCAGCAACTGGGCATGGTGGCTCACTG
 401 TCTGTAATGTATTACCTGAGGCAGAAGACCACCTGAGGGTAGGAGTCAAGATCAGCCTGGGCAACATAGTGAGACGCTGT
 481 CTCTACAAAAAATAATTAGCCTGGCCTGGTGGTGCATGCCTAGTCCTAGCTGATCTGGAGGCTGACGTGGGAGGATTGCT
 561 TGAGCCTAGAGTGAGCTATTATCATGCCACTGTACAGCCTGGGTGTTCACAGATCTTGTGTCTCAAAGGTAGGCAGAGGC
 641 AGGAAAAGCAAGGAGCCAGAATTAAGAGGTTGGGTCAGTCTGCAGTGAGTTCATGCATTTAGAGGTGTTCTTCAAGATGA
 721 CTAATGTCAAAAATTGAGACATCTGTTGCGGTTTTTTTTTTTTTTTTTTCCCCTGGAATGCAGTGGCGTGATCTCAGCTC
 801 ACTGCAGCCTCCGCCTCCTGGGTTCAAGTGATTCTAGTGCCTCAGCCTCCTGAGTAGCTGGGATAATGGGCGTGTGCCAC
 881 CATGCCCAGCTAATTTTTGTATTTTTAGTATAGATGGGGTTTCATCATTTTGACCAGGCTGGTCTCAAACTCTTGACCTC
 961 AGCTGATGCGCCTGCCTTGGCCTCCCAAACTGCTGAGATTACAGATGTGAGCCACCGCACCCTACCTCATTTTCTGTAAC
1041 AAAGCTAAGCTTGAACACTGTTGATGTTCTTGAGGGAAGCATATTGGGCTTTAGGCTGTAGGTCAAGTTTATACATCTTA
1121 ATTATGGTGGAATTCCTATGTAGAGTCTAAAAAGCCAGGTACTTGGTGCTACAGTCAGTCTCCCTGCAGAGGGTTAAGGC
1201 GCAGACTACCTGCAGTGAGGAGGTACTGCTTGTAGCATATAGAGCCTCTCCCTAGCTTTGGTTATGGAGGCTTTGAGGTT
1281 TTGCAAACCTGACCAATTTAAGCCATAAGATCTGGTCAAAGGGATACCCTTCCCACTAAGGACTTGGTTTCTCAGGAAAT
1361 TATATGTACAGTGCTTGCTGGCAGTTAGATGTCAGGACAATCTAAGCTGAGAAAACCCCTTCTCTGCCCACCTTAACAGA
1441 CCTCTAGGGTTCTTAACCCAGCAATCAAGTTTGCCTATCCTAGAGGTGGCGGATTTGATCATTTGGTGTGTTGGGCAATT
1521 TTTGTTTTACTGTCTGGTTCCTTCTGCGTGAATTACCACCACCACCACTTGTGCATCTCAGTCTTGTGTGTTGTCTGGTT
1601 ACGTATTCCCTGGGTGATACCATTCAATGTCTTAATGTACTTGTGGCTCAGACCTGAGTGCAAGGTGGAAATAAACATCA
1681 AACATCTTTTCATTATCCCTA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' guCUGGACUCAUCGCGUUCCAc 5'
            |||||||||   ||||||| 
Target 5' caGACCTGAGT---GCAAGGTg 3'
 1649 - 1667 173.00 -31.20
2 
miRNA  3' guCUGGACUCAUCGCGUUCCac 5'
            |:|  ||  |  ||||||  
Target 5' gaGGCAGGA--AAAGCAAGGag 3'
 636 - 655 124.00 -14.70
3 
miRNA  3' gucUGGACUCAUCG------CGUUCCAc 5'
             |: | :| |||      ||| ||| 
Target 5' aaaATGTAGGCAGCAACTGGGCATGGTg 3'
 365 - 392 113.00 -14.94
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30522825 6 COSMIC
COSN30535771 41 COSMIC
COSN30159843 50 COSMIC
COSN19632944 64 COSMIC
COSN28509905 102 COSMIC
COSN20104206 228 COSMIC
COSN27786474 555 COSMIC
COSN20303380 582 COSMIC
COSN23248090 584 COSMIC
COSN20104212 754 COSMIC
COSN27291439 754 COSMIC
COSN27366407 754 COSMIC
COSN15350273 755 COSMIC
COSN8023415 756 COSMIC
COSN22499583 757 COSMIC
COSN20104213 770 COSMIC
COSN20562830 771 COSMIC
COSN27518377 774 COSMIC
COSN9990068 933 COSMIC
COSN8023416 1222 COSMIC
COSN24626913 1285 COSMIC
COSN27937483 1339 COSMIC
COSN20104214 1415 COSMIC
COSN25819019 1510 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1215991146 3 dbSNP
rs756729147 8 dbSNP
rs778610995 13 dbSNP
rs745573436 14 dbSNP
rs1255345032 15 dbSNP
rs771867229 18 dbSNP
rs913839962 20 dbSNP
rs1189315135 21 dbSNP
rs1368696162 22 dbSNP
rs1438632084 23 dbSNP
rs1156444464 28 dbSNP
rs561066382 31 dbSNP
rs1419742374 32 dbSNP
rs746822337 33 dbSNP
rs768649599 34 dbSNP
rs1161325011 36 dbSNP
rs761973517 37 dbSNP
rs886320707 39 dbSNP
rs1394685151 41 dbSNP
rs765301920 44 dbSNP
rs773456224 47 dbSNP
rs1043373937 48 dbSNP
rs1239764860 51 dbSNP
rs1004815182 52 dbSNP
rs763136493 53 dbSNP
rs903493344 55 dbSNP
rs996567587 60 dbSNP
rs1049447386 61 dbSNP
rs17860084 62 dbSNP
rs11547711 63 dbSNP
rs1213851100 64 dbSNP
rs11266776 66 dbSNP
rs1266550888 67 dbSNP
rs1211135693 77 dbSNP
rs1008843048 79 dbSNP
rs549994697 80 dbSNP
rs961971571 83 dbSNP
rs9961 86 dbSNP
rs1200608074 87 dbSNP
rs1029114773 89 dbSNP
rs995720018 91 dbSNP
rs1302275401 95 dbSNP
rs1381825535 98 dbSNP
rs1026996085 101 dbSNP
rs987840716 102 dbSNP
rs1381488144 105 dbSNP
rs571726170 106 dbSNP
rs1031011654 107 dbSNP
rs1377654230 111 dbSNP
rs1192026542 112 dbSNP
rs1447221260 118 dbSNP
rs980079962 119 dbSNP
rs1249494534 121 dbSNP
rs17860085 122 dbSNP
rs1384411428 126 dbSNP
rs879489327 129 dbSNP
rs1278601948 133 dbSNP
rs960142898 135 dbSNP
rs1347260948 136 dbSNP
rs1256595531 137 dbSNP
rs1227962560 145 dbSNP
rs547761897 149 dbSNP
rs913694610 150 dbSNP
rs1439915144 151 dbSNP
rs1339598188 152 dbSNP
rs1332148321 166 dbSNP
rs1416032911 168 dbSNP
rs8177829 172 dbSNP
rs1402306752 178 dbSNP
rs1166866454 197 dbSNP
rs945300886 199 dbSNP
rs1427259052 202 dbSNP
rs948252420 204 dbSNP
rs1043597514 207 dbSNP
rs924969682 210 dbSNP
rs1450505782 213 dbSNP
rs1237224764 215 dbSNP
rs566320533 216 dbSNP
rs1444578162 219 dbSNP
rs1257465790 224 dbSNP
rs17860086 225 dbSNP
rs386544857 225 dbSNP
rs8177830 225 dbSNP
rs1340112415 227 dbSNP
rs927084957 234 dbSNP
rs1049373004 243 dbSNP
rs1379060542 253 dbSNP
rs1229360866 256 dbSNP
rs938452146 263 dbSNP
rs1237916930 275 dbSNP
rs1278419093 279 dbSNP
rs1449934246 281 dbSNP
rs1356506938 287 dbSNP
rs1307308697 290 dbSNP
rs1057172010 293 dbSNP
rs1371819244 298 dbSNP
rs907551542 301 dbSNP
rs940583222 302 dbSNP
rs1287306236 309 dbSNP
rs1413542989 310 dbSNP
rs17860087 311 dbSNP
rs397704534 311 dbSNP
rs397816218 311 dbSNP
rs1369598395 312 dbSNP
rs1182025289 313 dbSNP
rs1482131744 315 dbSNP
rs1253979981 320 dbSNP
rs1206152160 326 dbSNP
rs1467373338 330 dbSNP
rs1213494971 332 dbSNP
rs890905522 333 dbSNP
rs191837591 337 dbSNP
rs1037648992 344 dbSNP
rs1356765539 344 dbSNP
rs1287676181 350 dbSNP
rs898988309 352 dbSNP
rs111735829 363 dbSNP
rs1050256694 366 dbSNP
rs776433516 371 dbSNP
rs1037609335 381 dbSNP
rs1363300481 382 dbSNP
rs374908469 385 dbSNP
rs1473172177 388 dbSNP
rs897287659 392 dbSNP
rs890504644 394 dbSNP
rs139105425 395 dbSNP
rs1414815085 398 dbSNP
rs144790995 401 dbSNP
rs1477723953 405 dbSNP
rs1245254518 409 dbSNP
rs1223992689 411 dbSNP
rs1452000934 416 dbSNP
rs1027263268 423 dbSNP
rs1031398871 430 dbSNP
rs1331215047 441 dbSNP
rs906100303 442 dbSNP
rs1218181648 450 dbSNP
rs1460689190 452 dbSNP
rs1276281024 454 dbSNP
rs1001568402 458 dbSNP
rs1331749511 459 dbSNP
rs1402250932 462 dbSNP
rs1320368078 464 dbSNP
rs11547708 469 dbSNP
rs1035691758 476 dbSNP
rs960400112 477 dbSNP
rs988875659 479 dbSNP
rs1340477771 480 dbSNP
rs1011101257 482 dbSNP
rs1246365464 484 dbSNP
rs143350466 487 dbSNP
rs1193147082 488 dbSNP
rs1454830980 496 dbSNP
rs969525332 499 dbSNP
rs980871301 500 dbSNP
rs1466064998 502 dbSNP
rs533067408 506 dbSNP
rs928149740 528 dbSNP
rs1309938173 533 dbSNP
rs1218919862 535 dbSNP
rs1021218140 536 dbSNP
rs1219286974 545 dbSNP
rs960033981 546 dbSNP
rs1294904057 547 dbSNP
rs17860088 548 dbSNP
rs1367735677 550 dbSNP
rs17860089 552 dbSNP
rs1447862087 565 dbSNP
rs541358110 570 dbSNP
rs1443028026 575 dbSNP
rs1178399101 576 dbSNP
rs1037618214 579 dbSNP
rs920469185 580 dbSNP
rs17860090 581 dbSNP
rs759041932 582 dbSNP
rs985569558 583 dbSNP
rs890315706 584 dbSNP
rs912191920 593 dbSNP
rs943793404 596 dbSNP
rs1210253920 598 dbSNP
rs753476943 599 dbSNP
rs754803033 602 dbSNP
rs1402847119 603 dbSNP
rs931498228 604 dbSNP
rs1397757417 606 dbSNP
rs764864527 610 dbSNP
rs765003104 616 dbSNP
rs1354336083 618 dbSNP
rs1010901698 623 dbSNP
rs11984372 626 dbSNP
rs574645132 635 dbSNP
rs1279708604 637 dbSNP
rs141838679 640 dbSNP
rs758334118 650 dbSNP
rs895785244 653 dbSNP
rs781206974 666 dbSNP
rs1225728868 670 dbSNP
rs1020393981 671 dbSNP
rs570848571 673 dbSNP
rs1415934042 685 dbSNP
rs181557589 688 dbSNP
rs767884699 695 dbSNP
rs979270449 718 dbSNP
rs1482462539 724 dbSNP
rs560929101 726 dbSNP
rs1346285458 736 dbSNP
rs953968318 738 dbSNP
rs1480788565 745 dbSNP
rs531716578 750 dbSNP
rs1320269261 751 dbSNP
rs10627827 752 dbSNP
rs1183800492 752 dbSNP
rs1390104503 752 dbSNP
rs1491447187 752 dbSNP
rs35100141 753 dbSNP
rs60471039 754 dbSNP
rs28403980 755 dbSNP
rs989631533 756 dbSNP
rs1426465599 757 dbSNP
rs1214693062 758 dbSNP
rs1329148092 760 dbSNP
rs1266743610 764 dbSNP
rs1230357944 765 dbSNP
rs1336371549 767 dbSNP
rs1300882737 768 dbSNP
rs567298870 768 dbSNP
rs992978462 769 dbSNP
rs117681717 770 dbSNP
rs751464359 770 dbSNP
rs57534886 771 dbSNP
rs1261466756 772 dbSNP
rs1490947685 773 dbSNP
rs1467513174 774 dbSNP
rs1170817458 776 dbSNP
rs985361164 779 dbSNP
rs565514926 780 dbSNP
rs1196320802 783 dbSNP
rs1419796428 787 dbSNP
rs1253234576 788 dbSNP
rs532605623 789 dbSNP
rs547925179 792 dbSNP
rs943741067 795 dbSNP
rs972797081 796 dbSNP
rs918372446 797 dbSNP
rs1464708924 799 dbSNP
rs1266803179 801 dbSNP
rs961791636 802 dbSNP
rs534741910 805 dbSNP
rs1231149911 806 dbSNP
rs920273857 810 dbSNP
rs1381345561 811 dbSNP
rs931864716 812 dbSNP
rs1362709223 813 dbSNP
rs190544520 813 dbSNP
rs879288197 814 dbSNP
rs548241826 818 dbSNP
rs1048595500 821 dbSNP
rs112278761 828 dbSNP
rs905995511 834 dbSNP
rs568616291 836 dbSNP
rs1395352234 843 dbSNP
rs569649936 854 dbSNP
rs1217463937 855 dbSNP
rs944591276 859 dbSNP
rs7784201 868 dbSNP
rs1186207073 869 dbSNP
rs558361547 872 dbSNP
rs1042104903 873 dbSNP
rs1486682608 878 dbSNP
rs1281336689 879 dbSNP
rs1434692731 881 dbSNP
rs1227897366 885 dbSNP
rs892512591 886 dbSNP
rs904657544 893 dbSNP
rs17860093 900 dbSNP
rs570990249 902 dbSNP
rs17860094 904 dbSNP
rs1416109911 922 dbSNP
rs953851611 924 dbSNP
rs1419736572 925 dbSNP
rs905224399 926 dbSNP
rs1007238452 935 dbSNP
rs1002396865 943 dbSNP
rs780290604 945 dbSNP
rs553096208 947 dbSNP
rs1452584224 953 dbSNP
rs965665942 958 dbSNP
rs896643259 963 dbSNP
rs1368446427 965 dbSNP
rs1004342499 967 dbSNP
rs1016183688 969 dbSNP
rs180875884 970 dbSNP
rs749539510 971 dbSNP
rs1388899244 978 dbSNP
rs973170802 984 dbSNP
rs1301813291 996 dbSNP
rs769049572 999 dbSNP
rs983841480 1003 dbSNP
rs149127139 1010 dbSNP
rs539726282 1017 dbSNP
rs1057480991 1018 dbSNP
rs17860095 1019 dbSNP
rs554578118 1034 dbSNP
rs1407453314 1041 dbSNP
rs773905068 1050 dbSNP
rs1041703910 1051 dbSNP
rs1329098217 1051 dbSNP
rs1410902333 1058 dbSNP
rs1390417472 1059 dbSNP
rs913755794 1061 dbSNP
rs904500541 1062 dbSNP
rs1419203883 1065 dbSNP
rs946784589 1067 dbSNP
rs186066318 1070 dbSNP
rs1450823365 1072 dbSNP
rs760202453 1073 dbSNP
rs1489313736 1081 dbSNP
rs1000249398 1083 dbSNP
rs754063499 1086 dbSNP
rs565236966 1089 dbSNP
rs889186398 1093 dbSNP
rs896699724 1098 dbSNP
rs1374816157 1099 dbSNP
rs1004887516 1105 dbSNP
rs190180753 1108 dbSNP
rs1418002212 1111 dbSNP
rs1330900718 1113 dbSNP
rs898690749 1114 dbSNP
rs1019863030 1117 dbSNP
rs1027440800 1120 dbSNP
rs1369857637 1124 dbSNP
rs1463306674 1134 dbSNP
rs1159013447 1139 dbSNP
rs1399055687 1140 dbSNP
rs1410164110 1144 dbSNP
rs1178007686 1149 dbSNP
rs1477854907 1149 dbSNP
rs1324264536 1158 dbSNP
rs1195310653 1160 dbSNP
rs541282758 1163 dbSNP
rs965326147 1171 dbSNP
rs994455541 1173 dbSNP
rs559881826 1177 dbSNP
rs1448162886 1185 dbSNP
rs953023262 1190 dbSNP
rs1318206154 1193 dbSNP
rs1284282396 1196 dbSNP
rs952331234 1201 dbSNP
rs1300424414 1202 dbSNP
rs10256842 1205 dbSNP
rs985775233 1216 dbSNP
rs557595348 1226 dbSNP
rs1320480821 1233 dbSNP
rs1429163958 1238 dbSNP
rs759127720 1240 dbSNP
rs1347447696 1250 dbSNP
rs1223317610 1254 dbSNP
rs958695092 1257 dbSNP
rs1313661382 1266 dbSNP
rs993051427 1279 dbSNP
rs965965519 1281 dbSNP
rs764942391 1284 dbSNP
rs988487824 1285 dbSNP
rs111718472 1287 dbSNP
rs1389251572 1294 dbSNP
rs530445666 1296 dbSNP
rs1041924292 1301 dbSNP
rs1486842236 1303 dbSNP
rs752517191 1305 dbSNP
rs533724784 1306 dbSNP
rs1242597032 1312 dbSNP
rs1208873345 1313 dbSNP
rs1282055329 1316 dbSNP
rs1200384396 1319 dbSNP
rs548898832 1320 dbSNP
rs936027333 1327 dbSNP
rs926669927 1329 dbSNP
rs1364750033 1330 dbSNP
rs1050377534 1336 dbSNP
rs1231116343 1337 dbSNP
rs1289944822 1338 dbSNP
rs889246170 1346 dbSNP
rs938100359 1355 dbSNP
rs563316951 1366 dbSNP
rs143238351 1368 dbSNP
rs1435511008 1368 dbSNP
rs1040891194 1369 dbSNP
rs900971124 1371 dbSNP
rs181164108 1385 dbSNP
rs1474008306 1392 dbSNP
rs1163847287 1393 dbSNP
rs1420164315 1395 dbSNP
rs1181166932 1400 dbSNP
rs6904 1401 dbSNP
rs1466484813 1402 dbSNP
rs1258933337 1403 dbSNP
rs1210961832 1406 dbSNP
rs4205 1412 dbSNP
rs888349701 1412 dbSNP
rs200684634 1415 dbSNP
rs995715092 1418 dbSNP
rs1296960158 1420 dbSNP
rs1460969732 1429 dbSNP
rs1005258001 1430 dbSNP
rs867905174 1439 dbSNP
rs1353662526 1442 dbSNP
rs1295265193 1458 dbSNP
rs1034016060 1460 dbSNP
rs958485989 1467 dbSNP
rs868381565 1476 dbSNP
rs572784239 1485 dbSNP
rs888834647 1486 dbSNP
rs1354828953 1489 dbSNP
rs1018594337 1490 dbSNP
rs966129731 1491 dbSNP
rs1353304769 1492 dbSNP
rs1188093033 1495 dbSNP
rs1471966872 1497 dbSNP
rs1024491128 1506 dbSNP
rs1248008524 1513 dbSNP
rs1178537473 1514 dbSNP
rs756214143 1517 dbSNP
rs1009477937 1519 dbSNP
rs1020865653 1522 dbSNP
rs1213449795 1523 dbSNP
rs14869 1525 dbSNP
rs534697821 1527 dbSNP
rs967927391 1528 dbSNP
rs1275571308 1530 dbSNP
rs1233999730 1533 dbSNP
rs1349901419 1535 dbSNP
rs1305133124 1540 dbSNP
rs1393302103 1541 dbSNP
rs1357518026 1542 dbSNP
rs546503585 1545 dbSNP
rs780053005 1546 dbSNP
rs1413157149 1547 dbSNP
rs1438398232 1548 dbSNP
rs926241723 1549 dbSNP
rs1165502859 1553 dbSNP
rs1361488463 1555 dbSNP
rs760284653 1555 dbSNP
rs1160862254 1559 dbSNP
rs1419367791 1560 dbSNP
rs1318257823 1562 dbSNP
rs1220260995 1566 dbSNP
rs936254271 1573 dbSNP
rs1193448830 1574 dbSNP
rs967940107 1585 dbSNP
rs148317436 1588 dbSNP
rs910508214 1593 dbSNP
rs535399349 1603 dbSNP
rs185715395 1604 dbSNP
rs746881865 1610 dbSNP
rs1438470209 1621 dbSNP
rs992677592 1628 dbSNP
rs1326504154 1634 dbSNP
rs1434206096 1637 dbSNP
rs1382682122 1649 dbSNP
rs1238698461 1651 dbSNP
rs897888855 1655 dbSNP
rs1376767572 1658 dbSNP
rs917913475 1659 dbSNP
rs556846068 1666 dbSNP
rs1452964053 1674 dbSNP
rs1397206476 1675 dbSNP
rs929821514 1680 dbSNP
rs1447000678 1685 dbSNP
rs140505462 1691 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions Flp-In T-REx 293-hAGO1 cells
Location of target site 3'UTR
Original Description (Extracted from the article) ... Validation of interactions identified by CLASH suppports their reliability. ...

- Helwak A; Kudla G; Dudnakova T; Tollervey D, 2013, Cell.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' gucuggacucaUCGCGUUCCAc 5'
                     ||:||||||| 
Target 5' ----------gAGTGCAAGGTg 3'
 		1 - 12
Article - Helwak A; Kudla G; Dudnakova T; Tollervey D
- Cell, 2013
MicroRNAs (miRNAs) play key roles in gene regulation, but reliable bioinformatic or experimental identification of their targets remains difficult. To provide an unbiased view of human miRNA targets, we developed a technique for ligation and sequencing of miRNA-target RNA duplexes associated with human AGO1. Here, we report data sets of more than 18,000 high-confidence miRNA-mRNA interactions. The binding of most miRNAs includes the 5' seed region, but around 60% of seed interactions are noncanonical, containing bulged or mismatched nucleotides. Moreover, seed interactions are generally accompanied by specific, nonseed base pairing. 18% of miRNA-mRNA interactions involve the miRNA 3' end, with little evidence for 5' contacts, and some of these were functionally validated. Analyses of miRNA:mRNA base pairing showed that miRNA species systematically differ in their target RNA interactions, and strongly overrepresented motifs were found in the interaction sites of several miRNAs. We speculate that these affect the response of RISC to miRNA-target binding.
LinkOut: [PMID: 23622248]
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
KIRC 0.271 0.01 0.289 0.01 65 Click to see details
LUAD -0.475 0.1 -0.567 0.06 9 Click to see details
LUSC -0.196 0.12 -0.128 0.22 38 Click to see details
BRCA 0.106 0.19 0.179 0.06 73 Click to see details
CESC 0.734 0.24 1.000 0.5 3 Click to see details
KICH 0.143 0.25 0.140 0.25 25 Click to see details
HNSC -0.104 0.27 -0.164 0.16 38 Click to see details
UCEC -0.152 0.27 0.011 0.48 19 Click to see details
BLCA 0.16 0.28 -0.085 0.38 16 Click to see details
PRAD -0.085 0.29 -0.078 0.31 44 Click to see details
CHOL 0.226 0.3 0.190 0.33 8 Click to see details
LIHC 0.08 0.3 0.101 0.25 45 Click to see details
ESCA 0.196 0.34 -0.179 0.35 7 Click to see details
PAAD -0.248 0.38 -0.400 0.3 4 Click to see details
THCA -0.041 0.38 -0.060 0.33 59 Click to see details
PCPG 0.218 0.43 0.500 0.33 3 Click to see details
KIRP -0.021 0.45 -0.040 0.41 32 Click to see details
STAD -0.01 0.48 0.174 0.17 31 Click to see details
STAD -0.01 0.48 0.174 0.17 31 Click to see details
35 hsa-miR-3200-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT052815 CDC37 cell division cycle 37 1 1
MIRT052816 ATP6V1E2 ATPase H+ transporting V1 subunit E2 1 1
MIRT052817 MCM3AP minichromosome maintenance complex component 3 associated protein 1 1
MIRT052818 NSUN4 NOP2/Sun RNA methyltransferase family member 4 1 1
MIRT052819 EXOC4 exocyst complex component 4 1 1
MIRT052820 DDB1 damage specific DNA binding protein 1 1 1
MIRT052821 CAD carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase 1 1
MIRT052822 RPL23 ribosomal protein L23 1 1
MIRT052823 TPT1 tumor protein, translationally-controlled 1 1 1
MIRT052824 RPSA ribosomal protein SA 1 1
MIRT052825 PPIA peptidylprolyl isomerase A 1 1
MIRT052826 SSRP1 structure specific recognition protein 1 1 1
MIRT052827 STX2 syntaxin 2 1 1
MIRT095464 PURA purine rich element binding protein A 2 4
MIRT325192 PSAT1 phosphoserine aminotransferase 1 2 2
MIRT447293 ZNF562 zinc finger protein 562 2 2
MIRT450360 GRAMD3 GRAM domain containing 2B 2 2
MIRT482917 ZNF845 zinc finger protein 845 2 2
MIRT498302 DCAF8 DDB1 and CUL4 associated factor 8 2 2
MIRT500041 PABPC3 poly(A) binding protein cytoplasmic 3 2 8
MIRT541475 ARHGAP12 Rho GTPase activating protein 12 2 12
MIRT556269 MAPK6 mitogen-activated protein kinase 6 2 2
MIRT565440 SURF4 surfeit 4 2 2
MIRT573386 GPR20 G protein-coupled receptor 20 2 2
MIRT627911 OCIAD2 OCIA domain containing 2 2 2
MIRT633645 SKAP2 src kinase associated phosphoprotein 2 2 2
MIRT643472 PDK3 pyruvate dehydrogenase kinase 3 2 2
MIRT646284 GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 2 2
MIRT647889 CD55 CD55 molecule (Cromer blood group) 2 2
MIRT664712 EIF4G3 eukaryotic translation initiation factor 4 gamma 3 2 2
MIRT668135 GINS2 GINS complex subunit 2 2 2
MIRT686490 TRIOBP TRIO and F-actin binding protein 2 2
MIRT709525 IGF2 insulin like growth factor 2 2 2
MIRT722252 NTMT1 N-terminal Xaa-Pro-Lys N-methyltransferase 1 2 2
MIRT755478 CAMK2A calcium/calmodulin dependent protein kinase II alpha 4 1
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-3200 Tamoxifen 2733525 NSC180973 approved resistant High Breast Cancer cell line (MCF-7, T47D)
hsa-mir-3200 Cisplatin 5460033 NSC119875 approved resistant High Gastric Cancer cell line (BGC823)
hsa-mir-3200 Ceritinib 57379345 NSC776422 approved sensitive High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-mir-3200 Tamoxifen 2733525 NSC180973 approved resistant cell line (MCF7)
hsa-mir-3200 Ceritinib 57379345 NSC776422 approved sensitive cell line (H3122)
hsa-mir-3200 Cisplatin 5460033 NSC119875 approved resistant cell line (BGC-823)
hsa-miR-3200-3p Fluorouracil 3385 NSC19893 approved resistant High Pancreatic Cancer cell line (PANC-1)
hsa-miR-3200-3p Gemcitabine 60750 NSC613327 approved resistant High Pancreatic Cancer cell line (PANC-1)
hsa-miR-3200-3p Plx-4720 24180719 NSC757438 sensitive High Thyroid Cancer cell line (8505c, BCPAP)
hsa-miR-3200-3p Ceritinib 57379345 NSC776422 approved sensitive High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-miR-3200-3p Vemurafenib 42611257 NSC761431 approved resistant cell line (451Lu)
hsa-miR-3200-3p Cisplatin 5460033 NSC119875 approved sensitive cell line
hsa-miR-3200-3p Gefitinib 123631 NSC715055 approved sensitive cell line (HCC827)
hsa-miR-3200-3p Paclitaxel 36314 NSC125973 approved sensitive cell line (HS578T)
hsa-miR-3200-3p Doxorubicin 31703 NSC123127 approved sensitive cell line (HS578T)
hsa-miR-3200-3p Fluorouracil 3385 NSC19893 approved sensitive cell line (HCT15)
hsa-miR-3200-3p Platinum 23939 resistant tissue (non-small cell lung cancer)
hsa-miR-3200-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-3200-3p Ceritinib 57379345 NSC776422 approved sensitive cell line (H3122)
hsa-miR-3200-3p Paclitaxel/Docetaxel/Vinorelbine/Doxorubicin/Etoposide sensitive cell line (Bads-200)

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