miRTarBase - #MIRT052869


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miRNA Infomation
miRNA namehsa-miR-3676-3p

Gene Information
Gene Symbol PIAS4   
Synonyms PIAS-gamma, PIASY, Piasg, ZMIZ6
Description protein inhibitor of activated STAT 4
Transcript NM_015897   
Expression
Putative miRNA Targets on PIAS4
3'UTR of PIAS4
(miRNA target sites are highlighted)		 
>PIAS4|NM_015897|3'UTR
   1 CCCCGGCCGCACACTCGACTTTCCTGGTGCTCACCACGCAGAGGGGCACGGGCCAGCCTCGGGCGCAGAGGGAGGAGTGA
  81 CCTTTCTTTTTCTTTTTATTGTCGTTCGTTTTGTTTTTCCACCCTTTTGCCTGGCTCCTGGCACCTGTACCTCTGGACTC
 161 TCCTATCGGGGGATTAAAAAAAAAAGTAAAATGACAAAAAAAGATACAAAAAAGAAAAATGAAACAAAAAAGTCAAACTC
 241 TTAAAAACAAGGCCGGCCACCCACACAGCCGCCTCCCCGGCTGGAGTCCGAGCCGGGAAGGGGTAGTGGGCGGGAGGGAC
 321 CAGGACGCCGCCCCGCGCCCTCCCCTCCGGATGCCCCGCCGCCCGCCGCCCTCTGCCCACGACCATTCCAGCCAGTGCGC
 401 GGGGACCCGGGCGGCGGGCGGTGGGGCGCAGCCCCTCTCTGGCGACCACTTTGACGTTTGTCTCTTCCTTTGCTTTTTCT
 481 CTGCAAATGCATCCTCGCCCAGAGACCCTCACGCGCCGAGCAGCGAGCGTTTTAGCCGAGAAGCCATGGAGTGGGTTGGG
 561 GCGGGGAGGGGCAGTAGGGTGGGGGGATGGGTGGGCAGGATGGGGGTACAGTGGGCGGCTGGGGAGGGTTTAGCCACAGA
 641 TGTGTTGTATTTTTTGAAAGTGCAATAATTTGGTATTTTGAAGACCCGGCGTGTGGTCAGGAACCCCCGGGGAAGGCGGG
 721 GGCCCAGGGTGCGGCACCGTGTGGCGTGGGGGGGTCTCAGTTTTCTAGCCAGCTACCTCGGTAATTCCAATTCAGGTTAA
 801 CTTCCCTACGGAACAGCACAGATGTCCACAGATGTCCACAGCTGCCGCCGCCGCCGCCGCCACCATACCCCGGTCCTTGG
 881 GGCATGGGTTGCGGTCGCTTCCCAAGGGGCAGCAGGGACCCCGGCCACCCCGGCTCTCGGTTTGGGTTGATTCCTCTCCT
 961 TTTTGCTCTTGGTTTTCCGACGGGTACGAGGCTGGCCCGGCACCCTGTCCCCCGGGAGCCTCACTCTTCCAGCAGGACCA
1041 GACCAGGGGCCTCCTTCCTGTCCCCAGGCGTTCCCGGCCCCTCGCAGGCCCCACCCATGCCCTTGGCCTCAGGGTCCAAC
1121 AACTGGGGGAGCTACCAGGGCTCTGCCTTCAGGAGCCCACAGCTGGGCACCCCCCTTGCCCCCCAGGAGACCGGGGCGCA
1201 GGCGGGGCACCGGCCTCACCTGGTTCTCCAACACCGCTGCCTGCGGTCTGTTTTGCTTTTGTCCTCCCCAGCCCAGAATT
1281 TTCCTTTGTATAAACAGAACTCCTAGTCAGGAAGCAATATCATTTCAGGTCTAAAGAAAGGGACGTGCATCTGGCCGAGG
1361 GCAGTTCAGTCTCACTGCAGAGCCCGCAGCCCGCTGCGCAGCTCGGCCCCTCCCGCCCGCACGGGCAGCTGAAGGCCGCT
1441 GTTTTCTAATATTTGTATTCTAATTTAATTGTTTTTAAAAAATGCAAATAAAAAAGGTCGAGGTGAAGCCAAAAAAAAAA
1521 AAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN26988964 17 COSMIC
COSN26988965 38 COSMIC
COSN30710744 66 COSMIC
COSN26717988 125 COSMIC
COSN20052060 135 COSMIC
COSN20093487 168 COSMIC
COSN28901344 186 COSMIC
COSN25586075 558 COSMIC
COSN25812637 581 COSMIC
COSN25134463 721 COSMIC
COSN4778207 856 COSMIC
COSN21329756 1154 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1173471757 3 dbSNP
rs574957494 5 dbSNP
rs781196248 6 dbSNP
rs369903714 9 dbSNP
rs777201304 10 dbSNP
rs1252741623 11 dbSNP
rs1267122521 16 dbSNP
rs1488738929 17 dbSNP
rs1191878518 18 dbSNP
rs1268187087 20 dbSNP
rs931370437 21 dbSNP
rs1199709038 22 dbSNP
rs1479586260 23 dbSNP
rs748921773 25 dbSNP
rs770776191 33 dbSNP
rs1257718462 37 dbSNP
rs774845443 39 dbSNP
rs772483629 40 dbSNP
rs1169012131 41 dbSNP
rs1352139932 42 dbSNP
rs1458809606 45 dbSNP
rs113197231 50 dbSNP
rs1363158371 51 dbSNP
rs1275186885 61 dbSNP
rs542710674 62 dbSNP
rs975981155 65 dbSNP
rs921063549 66 dbSNP
rs1389964859 69 dbSNP
rs955282315 74 dbSNP
rs1411267345 75 dbSNP
rs1353236418 82 dbSNP
rs1437751883 82 dbSNP
rs1318882851 83 dbSNP
rs940181220 84 dbSNP
rs553089341 87 dbSNP
rs1453062951 93 dbSNP
rs72976977 94 dbSNP
rs73918127 99 dbSNP
rs1315000275 101 dbSNP
rs1474336198 101 dbSNP
rs1186527715 102 dbSNP
rs1319972431 103 dbSNP
rs986494585 104 dbSNP
rs1280572106 105 dbSNP
rs112184024 108 dbSNP
rs904286573 109 dbSNP
rs14786 114 dbSNP
rs1268187771 117 dbSNP
rs1268720251 119 dbSNP
rs564770470 123 dbSNP
rs1283262658 124 dbSNP
rs913583860 125 dbSNP
rs1342643474 131 dbSNP
rs1031817713 135 dbSNP
rs945000688 139 dbSNP
rs1382142923 140 dbSNP
rs1390083160 141 dbSNP
rs1043671894 142 dbSNP
rs1459969315 144 dbSNP
rs530785241 146 dbSNP
rs1164061004 150 dbSNP
rs937897270 152 dbSNP
rs544198299 153 dbSNP
rs1183212155 161 dbSNP
rs1190825950 168 dbSNP
rs561101233 168 dbSNP
rs1009137448 169 dbSNP
rs1248603652 170 dbSNP
rs529820649 173 dbSNP
rs77769422 175 dbSNP
rs1018869742 176 dbSNP
rs1466761338 176 dbSNP
rs77774566 177 dbSNP
rs1251715005 184 dbSNP
rs1358101411 192 dbSNP
rs546416994 197 dbSNP
rs150006636 201 dbSNP
rs1422757147 202 dbSNP
rs1366504737 205 dbSNP
rs945868993 206 dbSNP
rs921296161 207 dbSNP
rs1324355748 208 dbSNP
rs952697049 208 dbSNP
rs1407279234 212 dbSNP
rs1159132164 213 dbSNP
rs1165903431 217 dbSNP
rs1448669389 218 dbSNP
rs377174475 225 dbSNP
rs1413359257 226 dbSNP
rs1459223024 231 dbSNP
rs894587247 237 dbSNP
rs781549379 238 dbSNP
rs1014303725 241 dbSNP
rs1245612892 243 dbSNP
rs746220346 243 dbSNP
rs1452943678 244 dbSNP
rs1304842858 251 dbSNP
rs1204822313 252 dbSNP
rs1343332878 253 dbSNP
rs563388633 255 dbSNP
rs887110347 259 dbSNP
rs1288998652 261 dbSNP
rs1367584082 264 dbSNP
rs993365036 268 dbSNP
rs1004138341 271 dbSNP
rs1017222732 272 dbSNP
rs1267324497 276 dbSNP
rs963288403 277 dbSNP
rs997050643 279 dbSNP
rs1044656297 280 dbSNP
rs1211928288 283 dbSNP
rs1389098427 284 dbSNP
rs1452476494 285 dbSNP
rs1235407931 287 dbSNP
rs1424422934 288 dbSNP
rs935648504 290 dbSNP
rs1478736526 291 dbSNP
rs1482692565 295 dbSNP
rs147112970 296 dbSNP
rs1028898709 302 dbSNP
rs1277193522 305 dbSNP
rs1209236502 306 dbSNP
rs1460141183 307 dbSNP
rs1279982328 308 dbSNP
rs1312086471 308 dbSNP
rs955540414 312 dbSNP
rs552501955 313 dbSNP
rs913614826 317 dbSNP
rs370104068 327 dbSNP
rs1309588991 328 dbSNP
rs966399699 328 dbSNP
rs1008750873 329 dbSNP
rs1473886217 330 dbSNP
rs1019166052 331 dbSNP
rs1411821561 333 dbSNP
rs569162878 335 dbSNP
rs925246161 336 dbSNP
rs1253568481 337 dbSNP
rs1357646900 339 dbSNP
rs1483138504 340 dbSNP
rs1465724529 341 dbSNP
rs1212856159 343 dbSNP
rs996075752 345 dbSNP
rs1229133697 346 dbSNP
rs2890214 348 dbSNP
rs1331434835 349 dbSNP
rs937912119 350 dbSNP
rs1378176190 355 dbSNP
rs1394010061 355 dbSNP
rs1450106472 355 dbSNP
rs952749535 355 dbSNP
rs1386419053 356 dbSNP
rs984494999 357 dbSNP
rs1015682169 358 dbSNP
rs1055020852 359 dbSNP
rs917758960 361 dbSNP
rs1035197653 362 dbSNP
rs1414961109 364 dbSNP
rs1045798460 365 dbSNP
rs887187371 366 dbSNP
rs538504321 368 dbSNP
rs948847058 369 dbSNP
rs1004210514 372 dbSNP
rs1271430749 373 dbSNP
rs1276161878 373 dbSNP
rs1311318298 375 dbSNP
rs1244322788 376 dbSNP
rs926182371 378 dbSNP
rs1205412269 381 dbSNP
rs1276206147 382 dbSNP
rs960518015 388 dbSNP
rs1038760947 390 dbSNP
rs1319827591 394 dbSNP
rs1481804478 398 dbSNP
rs867529782 399 dbSNP
rs898778440 400 dbSNP
rs138503894 401 dbSNP
rs891558514 402 dbSNP
rs1167300073 407 dbSNP
rs1390034809 408 dbSNP
rs944485205 408 dbSNP
rs1189779817 409 dbSNP
rs371986296 410 dbSNP
rs1451952143 411 dbSNP
rs1265338356 412 dbSNP
rs568805207 413 dbSNP
rs1028551331 416 dbSNP
rs1267486334 416 dbSNP
rs900383939 417 dbSNP
rs1423483225 420 dbSNP
rs955528291 421 dbSNP
rs534373385 422 dbSNP
rs1229040779 428 dbSNP
rs1020754960 429 dbSNP
rs1298520793 432 dbSNP
rs966430721 433 dbSNP
rs887657632 438 dbSNP
rs979120245 439 dbSNP
rs1390945540 443 dbSNP
rs1032435388 444 dbSNP
rs959044506 445 dbSNP
rs1370332964 455 dbSNP
rs554455115 456 dbSNP
rs917805493 457 dbSNP
rs1307437547 462 dbSNP
rs1350406052 464 dbSNP
rs949257853 464 dbSNP
rs1433860143 465 dbSNP
rs983248192 468 dbSNP
rs1180288825 474 dbSNP
rs908657936 474 dbSNP
rs770071219 482 dbSNP
rs940096809 491 dbSNP
rs926193724 492 dbSNP
rs957829608 497 dbSNP
rs1272917022 498 dbSNP
rs111560835 499 dbSNP
rs1228815781 506 dbSNP
rs912915733 509 dbSNP
rs1308981020 510 dbSNP
rs898509905 511 dbSNP
rs545136675 513 dbSNP
rs558497259 514 dbSNP
rs181802690 516 dbSNP
rs1472369281 517 dbSNP
rs1048857834 518 dbSNP
rs1008423152 519 dbSNP
rs1224394142 525 dbSNP
rs1021119833 526 dbSNP
rs1245388194 527 dbSNP
rs1005236819 529 dbSNP
rs1036263028 530 dbSNP
rs1226079794 533 dbSNP
rs1189562378 538 dbSNP
rs897186641 539 dbSNP
rs1014245397 541 dbSNP
rs1024402194 550 dbSNP
rs902653979 552 dbSNP
rs1447818424 558 dbSNP
rs1405033279 559 dbSNP
rs544226354 562 dbSNP
rs1032050497 563 dbSNP
rs1033209547 564 dbSNP
rs1414609981 565 dbSNP
rs1471970581 567 dbSNP
rs972207482 568 dbSNP
rs957544392 569 dbSNP
rs989509235 571 dbSNP
rs1407062499 573 dbSNP
rs1464058076 575 dbSNP
rs1268288861 580 dbSNP
rs918798287 581 dbSNP
rs1353885113 586 dbSNP
rs930122369 589 dbSNP
rs1349179368 593 dbSNP
rs984381093 593 dbSNP
rs1385553701 595 dbSNP
rs1435559478 596 dbSNP
rs1434383545 599 dbSNP
rs1338952186 602 dbSNP
rs1389461111 604 dbSNP
rs1322221073 607 dbSNP
rs1403791383 613 dbSNP
rs1390338689 617 dbSNP
rs959304437 618 dbSNP
rs913476963 620 dbSNP
rs1227191618 627 dbSNP
rs1473015061 629 dbSNP
rs966109066 636 dbSNP
rs1186593162 640 dbSNP
rs1448853487 641 dbSNP
rs975682134 650 dbSNP
rs990489833 657 dbSNP
rs1449476281 665 dbSNP
rs931702548 676 dbSNP
rs1357808044 681 dbSNP
rs1362047519 685 dbSNP
rs1295947390 687 dbSNP
rs1048783405 688 dbSNP
rs1024890863 689 dbSNP
rs1226083266 691 dbSNP
rs1330689219 692 dbSNP
rs780218089 695 dbSNP
rs940530017 699 dbSNP
rs1166539113 700 dbSNP
rs970602833 705 dbSNP
rs1209758002 706 dbSNP
rs983278914 707 dbSNP
rs896369566 708 dbSNP
rs1014673279 709 dbSNP
rs561000670 710 dbSNP
rs907728215 713 dbSNP
rs765470691 715 dbSNP
rs1204943400 717 dbSNP
rs974567317 718 dbSNP
rs919988837 719 dbSNP
rs1033093374 722 dbSNP
rs932678948 725 dbSNP
rs879151901 730 dbSNP
rs1417082315 733 dbSNP
rs1049731758 734 dbSNP
rs750669323 739 dbSNP
rs891412153 740 dbSNP
rs1354980641 743 dbSNP
rs1020959936 744 dbSNP
rs749377885 746 dbSNP
rs1042637339 747 dbSNP
rs1481195229 748 dbSNP
rs966297896 748 dbSNP
rs1249201052 750 dbSNP
rs975734702 755 dbSNP
rs529983536 769 dbSNP
rs953028706 781 dbSNP
rs1001005671 791 dbSNP
rs1442401082 794 dbSNP
rs1283024171 803 dbSNP
rs1279387346 807 dbSNP
rs1334840938 808 dbSNP
rs984542179 810 dbSNP
rs1287982313 814 dbSNP
rs1041945973 817 dbSNP
rs940527326 817 dbSNP
rs1299730932 830 dbSNP
rs1270473268 832 dbSNP
rs1336766462 836 dbSNP
rs971883005 836 dbSNP
rs1157965911 841 dbSNP
rs917844057 841 dbSNP
rs187597826 842 dbSNP
rs1044986296 844 dbSNP
rs1267664793 844 dbSNP
rs1410594080 844 dbSNP
rs905902514 844 dbSNP
rs937317599 844 dbSNP
rs1209585314 846 dbSNP
rs1444273168 847 dbSNP
rs559924971 848 dbSNP
rs1226426668 851 dbSNP
rs1378283514 851 dbSNP
rs1185593682 852 dbSNP
rs768806416 853 dbSNP
rs1319368621 854 dbSNP
rs1385799777 854 dbSNP
rs1453970870 856 dbSNP
rs894894880 857 dbSNP
rs532422874 859 dbSNP
rs745755121 860 dbSNP
rs763124170 860 dbSNP
rs901993623 866 dbSNP
rs997745010 868 dbSNP
rs1247470347 869 dbSNP
rs1189339111 871 dbSNP
rs1024585174 872 dbSNP
rs970340905 873 dbSNP
rs552414320 876 dbSNP
rs1320894015 877 dbSNP
rs1292311761 879 dbSNP
rs1403914132 882 dbSNP
rs1016430355 883 dbSNP
rs1412399278 885 dbSNP
rs961796450 893 dbSNP
rs1350546183 894 dbSNP
rs1014757062 897 dbSNP
rs148317529 898 dbSNP
rs1291438948 912 dbSNP
rs1457156661 917 dbSNP
rs1366571458 922 dbSNP
rs973253654 923 dbSNP
rs1390132048 928 dbSNP
rs920028196 928 dbSNP
rs917782685 932 dbSNP
rs1430391643 933 dbSNP
rs370976817 934 dbSNP
rs954142113 937 dbSNP
rs1490591052 939 dbSNP
rs985512844 940 dbSNP
rs1339919074 941 dbSNP
rs1198920594 947 dbSNP
rs1227439395 953 dbSNP
rs1308749921 954 dbSNP
rs1298637079 955 dbSNP
rs1385857690 957 dbSNP
rs937329271 961 dbSNP
rs1305295235 966 dbSNP
rs1408407703 968 dbSNP
rs1054440153 971 dbSNP
rs912584619 979 dbSNP
rs1249551737 980 dbSNP
rs1464039961 982 dbSNP
rs1375985396 983 dbSNP
rs189946702 988 dbSNP
rs766175265 989 dbSNP
rs548592564 999 dbSNP
rs1201243109 1000 dbSNP
rs116076186 1003 dbSNP
rs774259208 1006 dbSNP
rs1481606042 1007 dbSNP
rs1172595891 1009 dbSNP
rs902057677 1010 dbSNP
rs1323735086 1012 dbSNP
rs1370748080 1014 dbSNP
rs534541653 1021 dbSNP
rs1284816477 1024 dbSNP
rs997630292 1029 dbSNP
rs936872287 1034 dbSNP
rs1350248816 1037 dbSNP
rs1431117909 1037 dbSNP
rs1029205387 1045 dbSNP
rs1053942347 1046 dbSNP
rs1305570681 1048 dbSNP
rs1395046682 1055 dbSNP
rs751266019 1059 dbSNP
rs894920095 1064 dbSNP
rs539572746 1070 dbSNP
rs1431636634 1071 dbSNP
rs1157212811 1073 dbSNP
rs1333155903 1073 dbSNP
rs1046109302 1074 dbSNP
rs867744902 1076 dbSNP
rs1004472457 1077 dbSNP
rs1343071520 1079 dbSNP
rs1014829075 1081 dbSNP
rs369250823 1084 dbSNP
rs1272569511 1085 dbSNP
rs1349567238 1086 dbSNP
rs1280469896 1096 dbSNP
rs1241663568 1098 dbSNP
rs1339167977 1102 dbSNP
rs995107208 1103 dbSNP
rs1408375147 1107 dbSNP
rs1318682240 1115 dbSNP
rs1456886590 1118 dbSNP
rs1210338524 1124 dbSNP
rs1025137737 1136 dbSNP
rs1158877994 1142 dbSNP
rs1455162354 1151 dbSNP
rs1269251734 1162 dbSNP
rs1366573357 1168 dbSNP
rs970557703 1171 dbSNP
rs752647989 1175 dbSNP
rs953310206 1176 dbSNP
rs926546800 1179 dbSNP
rs10405522 1184 dbSNP
rs10405525 1187 dbSNP
rs117110626 1193 dbSNP
rs1247325262 1194 dbSNP
rs1385679431 1198 dbSNP
rs1295448520 1201 dbSNP
rs1430137049 1201 dbSNP
rs1327184094 1204 dbSNP
rs965401763 1205 dbSNP
rs914600898 1210 dbSNP
rs777333817 1213 dbSNP
rs978082610 1216 dbSNP
rs924213428 1217 dbSNP
rs1425187684 1219 dbSNP
rs558351304 1230 dbSNP
rs1166117957 1232 dbSNP
rs1054419877 1234 dbSNP
rs1242264678 1236 dbSNP
rs916774846 1237 dbSNP
rs948181172 1245 dbSNP
rs1050529985 1246 dbSNP
rs889378526 1249 dbSNP
rs1340144888 1255 dbSNP
rs1293587380 1256 dbSNP
rs1046140317 1262 dbSNP
rs1434552258 1265 dbSNP
rs906284429 1267 dbSNP
rs1004544950 1271 dbSNP
rs1035972978 1274 dbSNP
rs1302257647 1276 dbSNP
rs1006500855 1285 dbSNP
rs1306963912 1289 dbSNP
rs545212450 1291 dbSNP
rs1267172103 1292 dbSNP
rs1409363625 1296 dbSNP
rs1419585631 1304 dbSNP
rs1169188645 1307 dbSNP
rs748942641 1309 dbSNP
rs1332505052 1312 dbSNP
rs1212908822 1318 dbSNP
rs897525401 1319 dbSNP
rs770438040 1324 dbSNP
rs1186242358 1332 dbSNP
rs1204421416 1336 dbSNP
rs1029286000 1345 dbSNP
rs1275167524 1346 dbSNP
rs1217575494 1349 dbSNP
rs970444857 1352 dbSNP
rs537438838 1357 dbSNP
rs888961416 1358 dbSNP
rs1347149251 1362 dbSNP
rs1166211520 1364 dbSNP
rs554184014 1365 dbSNP
rs1330258146 1371 dbSNP
rs1460338288 1371 dbSNP
rs1450430302 1372 dbSNP
rs148023396 1373 dbSNP
rs376395571 1373 dbSNP
rs768659614 1373 dbSNP
rs371238760 1375 dbSNP
rs989450158 1377 dbSNP
rs913798864 1384 dbSNP
rs1481245788 1385 dbSNP
rs574350502 1386 dbSNP
rs540137834 1387 dbSNP
rs1361472148 1390 dbSNP
rs1208039051 1391 dbSNP
rs559888459 1391 dbSNP
rs778655934 1393 dbSNP
rs1031016735 1394 dbSNP
rs747267294 1398 dbSNP
rs1050456419 1399 dbSNP
rs989752400 1405 dbSNP
rs1373901088 1406 dbSNP
rs1281220679 1408 dbSNP
rs1268567827 1410 dbSNP
rs769152673 1411 dbSNP
rs376036814 1413 dbSNP
rs1330985236 1415 dbSNP
rs948258725 1419 dbSNP
rs546014064 1420 dbSNP
rs1483336475 1423 dbSNP
rs927742406 1423 dbSNP
rs940457379 1424 dbSNP
rs1410711353 1432 dbSNP
rs1183167790 1434 dbSNP
rs1444614198 1435 dbSNP
rs1036498123 1436 dbSNP
rs540264409 1438 dbSNP
rs762476574 1439 dbSNP
rs1214731906 1446 dbSNP
rs993196527 1452 dbSNP
rs562820433 1456 dbSNP
rs1413292490 1472 dbSNP
rs1050397769 1482 dbSNP
rs889025851 1486 dbSNP
rs199659719 1493 dbSNP
rs1008756995 1495 dbSNP
rs1454137169 1495 dbSNP
rs1001978975 1496 dbSNP
rs769961613 1497 dbSNP
rs1431086499 1498 dbSNP
rs893672589 1500 dbSNP
rs902992372 1501 dbSNP
rs531883485 1504 dbSNP
rs1165489046 1510 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions Flp-In T-REx 293-hAGO1 cells
Location of target site CDS
Original Description (Extracted from the article) ... Validation of interactions identified by CLASH suppports their reliability. ...

- Helwak A; Kudla G; Dudnakova T; Tollervey D, 2013, Cell.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' tttcGCACCCCCTTTGTGCc 5'
              | |||||||| :||| 
Target 5' gtcaCCTGGGGGAACTACGg 3'
 		3 - 22
Article - Helwak A; Kudla G; Dudnakova T; Tollervey D
- Cell, 2013
MicroRNAs (miRNAs) play key roles in gene regulation, but reliable bioinformatic or experimental identification of their targets remains difficult. To provide an unbiased view of human miRNA targets, we developed a technique for ligation and sequencing of miRNA-target RNA duplexes associated with human AGO1. Here, we report data sets of more than 18,000 high-confidence miRNA-mRNA interactions. The binding of most miRNAs includes the 5' seed region, but around 60% of seed interactions are noncanonical, containing bulged or mismatched nucleotides. Moreover, seed interactions are generally accompanied by specific, nonseed base pairing. 18% of miRNA-mRNA interactions involve the miRNA 3' end, with little evidence for 5' contacts, and some of these were functionally validated. Analyses of miRNA:mRNA base pairing showed that miRNA species systematically differ in their target RNA interactions, and strongly overrepresented motifs were found in the interaction sites of several miRNAs. We speculate that these affect the response of RISC to miRNA-target binding.
LinkOut: [PMID: 23622248]
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
6 hsa-miR-3676-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT052869 PIAS4 protein inhibitor of activated STAT 4 1 1
MIRT052870 DAG1 dystroglycan 1 1 1
MIRT052871 DYNC1LI2 dynein cytoplasmic 1 light intermediate chain 2 1 1
MIRT052872 USP7 ubiquitin specific peptidase 7 1 1
MIRT052873 PGD phosphogluconate dehydrogenase 1 1
MIRT052874 CTC1 CST telomere replication complex component 1 1 1
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-3676 Fluorouracil 3385 NSC19893 approved resistant High Pancreatic Cancer cell line (PANC-1)
hsa-miR-3676 Gemcitabine 60750 NSC613327 approved resistant High Pancreatic Cancer cell line (PANC-1)
hsa-miR-3676 Gemcitabine 60750 NSC613327 approved resistant Low Pancreatic Cancer cell line (SW1990)
hsa-miR-3676 Gemcitabine 60750 NSC613327 approved sensitive High Pancreatic Cancer cell line (SW1990)
hsa-miR-3676 Capecitabine 60953 approved sensitive High Colorectal Cancer tissue
hsa-miR-3676 Oxaliplatin 6857599 NSC266046 approved sensitive High Colorectal Cancer tissue
hsa-miR-3676 Cisplatin 5460033 NSC119875 approved resistant Low Cervical Cancer tissue
hsa-mir-3676 Dabrafenib 44462760 NSC764134 approved sensitive cell line (A375)
hsa-miR-3676 Gemcitabine 60750 NSC613327 approved resistant cell line (Panc1-GR3)
hsa-miR-3676 Gemcitabine 60750 NSC613327 approved resistant cell line (Panc1-GR4)
hsa-miR-3676-3p Gemcitabine 60750 NSC613327 approved resistant High Pancreatic Cancer cell line (SW1990)
hsa-miR-3676-3p Platinum 23939 sensitive High Ovarian Cancer tissue
hsa-miR-3676-3p Trametinib 11707110 NSC758246 approved sensitive High Melanoma cell line (M14) (1uM)
hsa-miR-3676-3p Trametinib 11707110 NSC758246 approved sensitive High Melanoma cell line (WM266) (1uM)
hsa-miR-3676-3p Vemurafenib 42611257 NSC761431 approved sensitive High Melanoma cell line (M14) (1uM)
hsa-miR-3676-3p Vemurafenib 42611257 NSC761431 approved sensitive High Melanoma cell line (WM266) (1uM)
hsa-miR-3676-3p Vemurafenib 42611257 NSC761431 approved sensitive cell line (LM17)
hsa-miR-3676-3p Vemurafenib 42611257 NSC761431 approved resistant cell line (LM43)
hsa-miR-3676-3p Vemurafenib 42611257 NSC761431 approved resistant cell line (LM36)
hsa-miR-3676-3p Vemurafenib 42611257 NSC761431 approved sensitive cell line (LM11)
hsa-miR-3676-3p Vemurafenib 42611257 NSC761431 approved sensitive cell line (LM16)
hsa-miR-3676-3p Vemurafenib 42611257 NSC761431 approved sensitive cell line (LM47)
hsa-miR-3676-3p Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (1500 ng/ml)
hsa-miR-3676-3p Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (100 ng/ml)

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