miRTarBase - #MIRT052873


—
miRNA Infomation
miRNA namehsa-miR-3676-3p

Gene Information
Gene Symbol PGD   
Synonyms 6PGD
Description phosphogluconate dehydrogenase
Transcript NM_002631   
Expression
Putative miRNA Targets on PGD
3'UTR of PGD
(miRNA target sites are highlighted)		 
>PGD|NM_002631|3'UTR
   1 TCATGCTGCTCCTGTCACCCTCCACGATTCCACAGACCAGGACATTCCATGTGCCTCATGGCACTGCCACCTGGCCCTTT
  81 GCCCTATTTTCTGTTCAGTTTTTTAAAAGTGTTGTAAGAGACTCCTGAGGAAGACACACAGTTTATTTGTAAAGTAGCTC
 161 TGTGAGAGCCACCATGCCCTCTGCCCTTGCCTCTTGGGACTGACCAGGAGCTGCTCATGTGCGTGAGAGTGGGAACCATC
 241 TCCTTGCGGCAGTGGCTTCCGCGTGCCCCGTGTGCTGGTGCGGTTCCCATCACGCAGACAGGAAGGGTGTTTGCGCACTC
 321 TGATCAACTGGAACCTCTGTATCATGCGGCTGAATTCCCTTTTTCCTTTACTCAATAAAAGCTACATCAGACTGATGCTC
 401 TTTCTCCAGATTCTTAGTCTCACCTCGGCCACATGGAGCCATTATCCCCATTGGCAGAAAGATTTTTCTTTAAAAAAAAA
 481 GACTAGAATAACACAAGAAACCACATTTAGGATTATGCTTCACTCAGAGGAGGCAGGCAGGGAGGACACACCAGGGGCTT
 561 TAATACACTGGGCATGTTTTCTTTCTCCAATTGGGCAATGGGTACATGGACGTTCACTGTAACGTGCTTTTTCTTTCGTC
 641 TTTTTTTTTTTTTTTTTTTTTTTTGCTCCTGGCAAGCTGTGCGTGACATTCTTTATGGCTTTTTGTATGTCAAATACTTC
 721 ATACTAAACTTTCTAGAGAATTAAACTTTAATGATGGGCTCAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN23013821 18 COSMIC
COSN26988735 26 COSMIC
COSN30176391 26 COSMIC
COSN30504413 35 COSMIC
COSN31599859 36 COSMIC
COSN30464323 48 COSMIC
COSN8883878 58 COSMIC
COSN31580839 92 COSMIC
COSN28882318 105 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1200326275 1 dbSNP
rs764613197 6 dbSNP
rs1224874105 9 dbSNP
rs752016513 10 dbSNP
rs199902976 15 dbSNP
rs1206428866 17 dbSNP
rs1187035766 20 dbSNP
rs1050573223 26 dbSNP
rs1486076317 27 dbSNP
rs1208980110 32 dbSNP
rs1265206301 37 dbSNP
rs910621087 38 dbSNP
rs750145525 39 dbSNP
rs779516753 40 dbSNP
rs753393623 42 dbSNP
rs201142821 44 dbSNP
rs1292668274 50 dbSNP
rs1332560052 52 dbSNP
rs916634601 55 dbSNP
rs751184533 56 dbSNP
rs1040357618 64 dbSNP
rs1241123090 65 dbSNP
rs574321235 70 dbSNP
rs1193728304 83 dbSNP
rs897809267 90 dbSNP
rs948137446 99 dbSNP
rs1046542514 105 dbSNP
rs906519946 107 dbSNP
rs1156766696 108 dbSNP
rs1474527063 113 dbSNP
rs1387585526 115 dbSNP
rs1457577486 117 dbSNP
rs1321399380 125 dbSNP
rs999560603 130 dbSNP
rs1052702513 134 dbSNP
rs1415220555 134 dbSNP
rs894054365 134 dbSNP
rs1011042736 136 dbSNP
rs1029590130 155 dbSNP
rs1220396485 161 dbSNP
rs953107217 161 dbSNP
rs1306470935 167 dbSNP
rs1224602841 169 dbSNP
rs929587787 173 dbSNP
rs544588397 175 dbSNP
rs1247560352 190 dbSNP
rs1278323623 197 dbSNP
rs887988577 202 dbSNP
rs556782913 214 dbSNP
rs1018677132 217 dbSNP
rs1209651749 218 dbSNP
rs780906979 219 dbSNP
rs1484859013 220 dbSNP
rs111816414 223 dbSNP
rs747951320 224 dbSNP
rs1168381339 225 dbSNP
rs1379393754 228 dbSNP
rs1276106279 229 dbSNP
rs920484340 239 dbSNP
rs904943583 243 dbSNP
rs1289439321 246 dbSNP
rs578230577 248 dbSNP
rs545595112 249 dbSNP
rs746504867 257 dbSNP
rs1347923305 261 dbSNP
rs1277679615 262 dbSNP
rs1346240893 262 dbSNP
rs1034696169 263 dbSNP
rs956349015 264 dbSNP
rs1179488121 266 dbSNP
rs988080032 267 dbSNP
rs1022631755 270 dbSNP
rs560336478 271 dbSNP
rs1454720165 279 dbSNP
rs935309504 282 dbSNP
rs1393492834 283 dbSNP
rs1403682706 289 dbSNP
rs1159530103 294 dbSNP
rs7551837 295 dbSNP
rs910348812 298 dbSNP
rs1295151382 299 dbSNP
rs777717292 300 dbSNP
rs749171188 302 dbSNP
rs1371114534 306 dbSNP
rs1439506742 309 dbSNP
rs1300892186 313 dbSNP
rs946975410 315 dbSNP
rs533844450 316 dbSNP
rs1285428985 319 dbSNP
rs1316631133 328 dbSNP
rs1214291161 335 dbSNP
rs1275582783 336 dbSNP
rs919281991 342 dbSNP
rs1050721955 344 dbSNP
rs929303346 348 dbSNP
rs1471295202 349 dbSNP
rs1177961634 352 dbSNP
rs1406987908 358 dbSNP
rs1402949195 360 dbSNP
rs1397859871 372 dbSNP
rs775477791 376 dbSNP
rs1306652374 377 dbSNP
rs1460503026 379 dbSNP
rs11547608 391 dbSNP
rs1229595045 397 dbSNP
rs1401790644 399 dbSNP
rs948959679 405 dbSNP
rs1442487245 407 dbSNP
rs897582033 414 dbSNP
rs993143045 418 dbSNP
rs763291605 427 dbSNP
rs1027746224 428 dbSNP
rs951769767 434 dbSNP
rs1213558819 447 dbSNP
rs1271385592 449 dbSNP
rs144487431 450 dbSNP
rs190249258 452 dbSNP
rs1003324095 453 dbSNP
rs1193557055 455 dbSNP
rs1189761860 461 dbSNP
rs1134021 462 dbSNP
rs1474853369 465 dbSNP
rs991803670 469 dbSNP
rs1022922594 472 dbSNP
rs528257541 472 dbSNP
rs59990300 472 dbSNP
rs1034750158 473 dbSNP
rs148014763 474 dbSNP
rs1315208555 481 dbSNP
rs1356462519 481 dbSNP
rs1233217566 485 dbSNP
rs1291919564 486 dbSNP
rs981277751 495 dbSNP
rs928002402 498 dbSNP
rs1140438 504 dbSNP
rs549825611 505 dbSNP
rs577059758 506 dbSNP
rs1213230002 508 dbSNP
rs1140439 523 dbSNP
rs935428216 524 dbSNP
rs1175539468 526 dbSNP
rs988137787 531 dbSNP
rs968374932 532 dbSNP
rs1185789866 542 dbSNP
rs1374720162 543 dbSNP
rs1140440 549 dbSNP
rs1166780498 554 dbSNP
rs1475477015 554 dbSNP
rs915206790 557 dbSNP
rs577988570 564 dbSNP
rs773880241 567 dbSNP
rs1140441 568 dbSNP
rs1173804983 569 dbSNP
rs986042787 571 dbSNP
rs532205321 572 dbSNP
rs1311668923 579 dbSNP
rs1017870173 586 dbSNP
rs1328676649 586 dbSNP
rs142347855 591 dbSNP
rs1269697697 602 dbSNP
rs1140442 604 dbSNP
rs976174839 607 dbSNP
rs919331903 608 dbSNP
rs929357145 612 dbSNP
rs1208423047 616 dbSNP
rs1263823578 618 dbSNP
rs557068864 619 dbSNP
rs1386577931 624 dbSNP
rs909192118 625 dbSNP
rs566665396 627 dbSNP
rs1302483116 630 dbSNP
rs926074767 634 dbSNP
rs1193941895 636 dbSNP
rs148468089 637 dbSNP
rs948999382 638 dbSNP
rs1171163987 639 dbSNP
rs1387536993 640 dbSNP
rs1183487352 641 dbSNP
rs1204496461 641 dbSNP
rs1213742579 641 dbSNP
rs1252044987 641 dbSNP
rs1282052513 641 dbSNP
rs1351039561 641 dbSNP
rs1364956619 641 dbSNP
rs1365920638 641 dbSNP
rs1370493283 641 dbSNP
rs140049314 641 dbSNP
rs1401828725 641 dbSNP
rs1431046952 641 dbSNP
rs1452210691 641 dbSNP
rs1469475526 641 dbSNP
rs1491518813 641 dbSNP
rs397979181 641 dbSNP
rs70997229 641 dbSNP
rs756832598 641 dbSNP
rs774620494 641 dbSNP
rs778264823 641 dbSNP
rs1491158223 642 dbSNP
rs1273251516 643 dbSNP
rs1342282556 644 dbSNP
rs1207160975 645 dbSNP
rs993670206 646 dbSNP
rs1487999904 663 dbSNP
rs1191539478 664 dbSNP
rs1044638685 665 dbSNP
rs1385311468 665 dbSNP
rs1393774744 665 dbSNP
rs1309352516 666 dbSNP
rs12061972 671 dbSNP
rs1134026 677 dbSNP
rs1027436070 679 dbSNP
rs1277747161 683 dbSNP
rs534025238 684 dbSNP
rs1214195218 686 dbSNP
rs887433293 687 dbSNP
rs1012623677 689 dbSNP
rs1197242520 691 dbSNP
rs1250788654 696 dbSNP
rs1022852002 699 dbSNP
rs928811780 706 dbSNP
rs1410150390 710 dbSNP
rs555784165 714 dbSNP
rs1389592250 715 dbSNP
rs1140445 716 dbSNP
rs567566355 721 dbSNP
rs1166195298 722 dbSNP
rs971314412 730 dbSNP
rs538210538 734 dbSNP
rs981244789 734 dbSNP
rs1140446 737 dbSNP
rs955921229 741 dbSNP
rs938828969 744 dbSNP
rs1056261178 748 dbSNP
rs1390657581 750 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions Flp-In T-REx 293-hAGO1 cells
Location of target site CDS
Original Description (Extracted from the article) ... Validation of interactions identified by CLASH suppports their reliability. ...

- Helwak A; Kudla G; Dudnakova T; Tollervey D, 2013, Cell.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' ttTCG-CACC---CC--CTTTGTGCc 5'
            ||: ||||   ||  |:::| || 
Target 5' tcAGTGGTGGAGAGGAAGGGGCCCGg 3'
 		22 - 47
2 
miRNA  3' tttcgcACCCCCTTTGTgcc 5'
                || |||:|:|:   
Target 5' tttattTGTGGGGAGCGgag 3'
 		2 - 21
Article - Helwak A; Kudla G; Dudnakova T; Tollervey D
- Cell, 2013
MicroRNAs (miRNAs) play key roles in gene regulation, but reliable bioinformatic or experimental identification of their targets remains difficult. To provide an unbiased view of human miRNA targets, we developed a technique for ligation and sequencing of miRNA-target RNA duplexes associated with human AGO1. Here, we report data sets of more than 18,000 high-confidence miRNA-mRNA interactions. The binding of most miRNAs includes the 5' seed region, but around 60% of seed interactions are noncanonical, containing bulged or mismatched nucleotides. Moreover, seed interactions are generally accompanied by specific, nonseed base pairing. 18% of miRNA-mRNA interactions involve the miRNA 3' end, with little evidence for 5' contacts, and some of these were functionally validated. Analyses of miRNA:mRNA base pairing showed that miRNA species systematically differ in their target RNA interactions, and strongly overrepresented motifs were found in the interaction sites of several miRNAs. We speculate that these affect the response of RISC to miRNA-target binding.
LinkOut: [PMID: 23622248]
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
6 hsa-miR-3676-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT052869 PIAS4 protein inhibitor of activated STAT 4 1 1
MIRT052870 DAG1 dystroglycan 1 1 1
MIRT052871 DYNC1LI2 dynein cytoplasmic 1 light intermediate chain 2 1 1
MIRT052872 USP7 ubiquitin specific peptidase 7 1 1
MIRT052873 PGD phosphogluconate dehydrogenase 1 1
MIRT052874 CTC1 CST telomere replication complex component 1 1 1
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-3676 Fluorouracil 3385 NSC19893 approved resistant High Pancreatic Cancer cell line (PANC-1)
hsa-miR-3676 Gemcitabine 60750 NSC613327 approved resistant High Pancreatic Cancer cell line (PANC-1)
hsa-miR-3676 Gemcitabine 60750 NSC613327 approved resistant Low Pancreatic Cancer cell line (SW1990)
hsa-miR-3676 Gemcitabine 60750 NSC613327 approved sensitive High Pancreatic Cancer cell line (SW1990)
hsa-miR-3676 Capecitabine 60953 approved sensitive High Colorectal Cancer tissue
hsa-miR-3676 Oxaliplatin 6857599 NSC266046 approved sensitive High Colorectal Cancer tissue
hsa-miR-3676 Cisplatin 5460033 NSC119875 approved resistant Low Cervical Cancer tissue
hsa-mir-3676 Dabrafenib 44462760 NSC764134 approved sensitive cell line (A375)
hsa-miR-3676 Gemcitabine 60750 NSC613327 approved resistant cell line (Panc1-GR3)
hsa-miR-3676 Gemcitabine 60750 NSC613327 approved resistant cell line (Panc1-GR4)
hsa-miR-3676-3p Gemcitabine 60750 NSC613327 approved resistant High Pancreatic Cancer cell line (SW1990)
hsa-miR-3676-3p Platinum 23939 sensitive High Ovarian Cancer tissue
hsa-miR-3676-3p Trametinib 11707110 NSC758246 approved sensitive High Melanoma cell line (M14) (1uM)
hsa-miR-3676-3p Trametinib 11707110 NSC758246 approved sensitive High Melanoma cell line (WM266) (1uM)
hsa-miR-3676-3p Vemurafenib 42611257 NSC761431 approved sensitive High Melanoma cell line (M14) (1uM)
hsa-miR-3676-3p Vemurafenib 42611257 NSC761431 approved sensitive High Melanoma cell line (WM266) (1uM)
hsa-miR-3676-3p Vemurafenib 42611257 NSC761431 approved sensitive cell line (LM17)
hsa-miR-3676-3p Vemurafenib 42611257 NSC761431 approved resistant cell line (LM43)
hsa-miR-3676-3p Vemurafenib 42611257 NSC761431 approved resistant cell line (LM36)
hsa-miR-3676-3p Vemurafenib 42611257 NSC761431 approved sensitive cell line (LM11)
hsa-miR-3676-3p Vemurafenib 42611257 NSC761431 approved sensitive cell line (LM16)
hsa-miR-3676-3p Vemurafenib 42611257 NSC761431 approved sensitive cell line (LM47)
hsa-miR-3676-3p Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (1500 ng/ml)
hsa-miR-3676-3p Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (100 ng/ml)

Error report submission