miRTarBase - #MIRT053516


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pre-miRNA Information
pre-miRNA hsa-mir-539   
Genomic Coordinates chr14: 101047321 - 101047398
Synonyms MIRN539, hsa-mir-539, MIR539
Description Homo sapiens miR-539 stem-loop
Comment None
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-539-5p
Sequence 9| GGAGAAAUUAUCCUUGGUGUGU |30
Evidence Experimental
Experiments Cloned
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 10 14 + 101047338 22499667, 26449202, 27229138, 28550310, 29165639, 29233923 MiREDiBase
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs920592001 1 dbSNP
rs949143380 2 dbSNP
rs1037241141 4 dbSNP
rs1261686093 10 dbSNP
rs747290147 19 dbSNP
rs1397145918 22 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol ZEB1   
Synonyms AREB6, BZP, DELTAEF1, FECD6, NIL2A, PPCD3, TCF8, ZFHEP, ZFHX1A
Description zinc finger E-box binding homeobox 1
Transcript NM_001128128   
Other Transcripts NM_001174093 , NM_001174094 , NM_001174095 , NM_001174096 , NM_030751   
Expression
Putative miRNA Targets on ZEB1
3'UTR of ZEB1
(miRNA target sites are highlighted)		 
>ZEB1|NM_001128128|3'UTR
   1 TCGTTTTTCTAGAAGGAAAATAAATTCTAATTGATAATGAATTTCGTTCAATATTATCCTTGCTTTTCATGGAAACACAG
  81 TAACCTGTATGCTGTGATTCCTGTTCACTACTGTGTAAAGTAAAAACTAAAAAAATACAAAATACAAAACACACACACAC
 161 ACACACACACACACACACACACACACACAAAATAAATCCGGGTGTGCCTGAACCTCAGACCTAGTAATTTTTCATGCAGT
 241 TTTCAAAGTTAGGAACAAGTTTGTAACATGCAGCAGATTAGAAAACCTTAATGACTCAGAGAGCAACAATACAAGAGGTT
 321 AAAGGAAGCTGATTAATTAGATATGCATCTGGCATTGTTTTATCTTATCAGTATTATCACTCTTATGTTGGTTTATTCTT
 401 AAGCTGTACAATTGGGAGAAATTTTATAATTTTTTATTGGTAAACATATGCTAAATCCGCTTCAGTATTTTATTATGTTT
 481 TTTAAAATGTGAGAACTTCTGCACTACAAAATTCCCTTCACAGAGAAGTATAATGTAGTTCCAACCCGTGCTAACTACCT
 561 TTTATAAATTCAGTCTAGAAGGTAGTAATTTCTAATATTTAGATGTCTTAGTAGAGCGTATTATCATTTAAAGTGTATTG
 641 TTAGCCTTAAGAAAGCAGCTGATAGAAGAACTGAAGTTTCTTACTCACGTGGTTTAAAATGGAGTTCAAAAGATTGCCAT
 721 TGAGTTCTGATTGCAGGGACTAACAATGTTAATCTGATAAGGACAGCAAAATCATCAGAATCAGTGTTTGTGATTGTGTT
 801 TGAATATGTGGTAACATATGAAGGATATGACATGAAGCTTTGTATCTCCTTTGGCCTTAAGCAAGACCTGTGTGCTGTAA
 881 GTGCCATTTCTCAGTATTTTCAAGGCTCTAACCCGCCTTCATCCAATGTGTGGCCTACAATAACTAGCATTTGTTGATTT
 961 GTCTCTTGTATCAAAATTCCCAAATAAAACTTAAAACCACTGACTCTGTCAGAGAAACTGAAACACTGGGACATTTCATC
1041 CTTCAATTCCTCGGTATTGATTTTATGTTGATTGATTTTCAGAATTTCTCTACAGAAACGAAAGGGAAATTTTCTAATCT
1121 GCTTTATCCATGTACTTGCATTTCAGACATGGACATGCTATTGTTATTTGGCTCATAACTGTTTCCAAATGTTAGTTATT
1201 ATGGACCCAATTTATTAACAACATTAGCTGATTTTTACCTATCAGTATTATTTTATTTCTTTTAGTTTATAGATCTGTGC
1281 AACATTTTTGTACTGTATGTCTTCAAACCTGGCAGTATTAATACCCTTCTTACTGACATATGTACTTTTAGTTTTAGAAA
1361 ACTTTTATATTTATGTGTCTTATTTTTATATTTCTTTATTTATTACACAGTGTAGTGTATAATACTGTAGTTTGTATTAA
1441 TACAATAATATATTTTAGTATGAAAATTTGGAAAGTTGATAAGATTTAAAGTAGAGATGCAATTGGTTCTCCTGCATTGA
1521 GATTTGATTTAACAGTGTTATGTTAACATTTATACTTGCCTTGGACTGTAGAACAGAACTTAAATGGGAATGTATTAGTT
1601 TTACAACTACAATCAAGTCATTTTACCTTTACCCAGTTTTTAATATAAAACTTAAATTTTGAAATTCACTGTGTGACTAA
1681 TAGCATGATGCTCTGCAGTTTTATTAAGAAATCAGCCTAACCATACAACTCTCATTTCCTTAGTAAGCCAAATTAGGATT
1761 AACTTCTATAAACAGTGTTGGGAACAATGTTTAACATTTTGTGCCAATTTGTTCCTGTATTCATGTATGTAAGTTACAGA
1841 TCTGACTCTTCATTTTTAAGTTCCTTGTTACATCATGGTCATTTTCTAGTTTTTTACCAGACTCCCATCTCACAATAAAA
1921 TGCATCAACAAGCCTGAACTGCTGTCATTCTTTTCATCATTATCAGTATTTTCTTTGGAAAACTGTGAAATGGGGTACAT
2001 TGTCATCCTGCATTTGATTCATCTTGAGCTGAATTTGGGTAACACTAAATGTTTTAGACATTCTCCACTAAATTATGGAT
2081 TTTCTTGTGGCTAAATGTTTCTGGAGAGGTCAGAGTTGACAAAACCTCTTCACAGGTTGCTCCTTCTTCCTGAAATCCTT
2161 AATCCTCCGCATTTCATGCTTCAGGTCATTTCAGGGAAGCCTGGGTTTAGATGCCTTTCTGACTCTCAGCTCCTGCACTT
2241 CTGTCATCATACCTCTGATACTATTATTTATATTCCTTCCCCACTAGGAACAGGAACCACATTTGTCATAGTCACTCTCA
2321 CATTCCTCACTGCCTAACAGGGTGCCTGGCATAAGTTGGGACAACAGATATTTGTTGAATAAAAATATAATTTGCATGTT
2401 TATGGAGCTCAGCTATGTTCTCACTTTTTTTGCTTCTAATTCCAGAATATATGTTAAATGATCTAATAATTTGATTATTT
2481 TCTTATAAGTCTTATTAAACACTAGTCATAATAGACACAATAAATTATGCCTTCTTTTTCTATTGCCTTAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' ugUGUGGUUCCUAUUAAAGAGg 5'
            | ||| ||  ||||||:|| 
Target 5' tcAGACCTAG--TAATTTTTCa 3'
 215 - 234 148.00 -12.40
2 
miRNA  3' ugugugGUUCCUAUUAAAGAGg 5'
                :||| :  ||||||| 
Target 5' gtgctgTAAGTGCCATTTCTCa 3'
 872 - 893 148.00 -8.00
3 
miRNA  3' ugugugguuccUAUUAAAGAGg 5'
                     | |||||||| 
Target 5' gattgattttcAGAATTTCTCt 3'
 1070 - 1091 147.00 -7.30
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN21232253 13 COSMIC
COSN30534384 13 COSMIC
COSN18734779 28 COSMIC
COSN30535279 35 COSMIC
COSN30112435 46 COSMIC
COSN18734780 50 COSMIC
COSN28202021 155 COSMIC
COSN19324701 185 COSMIC
COSN20107022 187 COSMIC
COSN20107020 189 COSMIC
COSN30174989 189 COSMIC
COSN18758086 190 COSMIC
COSN27320736 190 COSMIC
COSN31519026 346 COSMIC
COSN31516310 366 COSMIC
COSN30174387 404 COSMIC
COSN31536783 412 COSMIC
COSN31575816 426 COSMIC
COSN6068733 449 COSMIC
COSN31565538 474 COSMIC
COSN8639620 548 COSMIC
COSN19468893 624 COSMIC
COSN31529324 685 COSMIC
COSN16403418 1050 COSMIC
COSN1485932 1062 COSMIC
COSN9204732 1073 COSMIC
COSN6966859 1203 COSMIC
COSN23779222 1469 COSMIC
COSN9028413 1616 COSMIC
COSN9204733 2098 COSMIC
COSN1118048 2271 COSMIC
COSN28201578 2318 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1293102186 3 dbSNP
rs757921093 4 dbSNP
rs1220717682 11 dbSNP
rs1426280170 13 dbSNP
rs188563673 14 dbSNP
rs1182125530 15 dbSNP
rs1460687884 28 dbSNP
rs1241061378 29 dbSNP
rs1306999336 30 dbSNP
rs746675048 32 dbSNP
rs1249531117 45 dbSNP
rs1484225271 46 dbSNP
rs113977142 47 dbSNP
rs374867798 51 dbSNP
rs747907284 52 dbSNP
rs551915194 56 dbSNP
rs78595841 70 dbSNP
rs549821982 71 dbSNP
rs971951064 75 dbSNP
rs928540374 78 dbSNP
rs868248754 86 dbSNP
rs938497223 98 dbSNP
rs994075732 102 dbSNP
rs991727140 104 dbSNP
rs915787084 106 dbSNP
rs947442366 113 dbSNP
rs535379956 128 dbSNP
rs1232335287 129 dbSNP
rs1491407503 129 dbSNP
rs1458089056 132 dbSNP
rs1440423772 136 dbSNP
rs1194042353 141 dbSNP
rs1181030271 142 dbSNP
rs571272065 143 dbSNP
rs1033631285 144 dbSNP
rs1267337741 144 dbSNP
rs1214903068 146 dbSNP
rs1246906484 147 dbSNP
rs1160153117 149 dbSNP
rs1179526370 149 dbSNP
rs1219135544 149 dbSNP
rs1223305416 149 dbSNP
rs1237432196 149 dbSNP
rs1260534963 149 dbSNP
rs1289825801 149 dbSNP
rs1351785467 149 dbSNP
rs1414359479 149 dbSNP
rs1414862834 149 dbSNP
rs1434846843 149 dbSNP
rs143911186 149 dbSNP
rs1470370512 149 dbSNP
rs1490226326 149 dbSNP
rs3086583 149 dbSNP
rs60354357 149 dbSNP
rs71027030 149 dbSNP
rs760917085 149 dbSNP
rs878998474 149 dbSNP
rs879005341 149 dbSNP
rs879078834 149 dbSNP
rs879201763 149 dbSNP
rs72221464 150 dbSNP
rs903166593 151 dbSNP
rs766569704 153 dbSNP
rs934662396 155 dbSNP
rs1343138236 157 dbSNP
rs1299624509 158 dbSNP
rs1444398754 164 dbSNP
rs1400967981 165 dbSNP
rs537121968 170 dbSNP
rs1164260485 171 dbSNP
rs1376030939 172 dbSNP
rs1041244916 177 dbSNP
rs1467448206 183 dbSNP
rs1406678405 184 dbSNP
rs1489457971 185 dbSNP
rs901414208 186 dbSNP
rs1198656625 187 dbSNP
rs1480138884 187 dbSNP
rs1326476840 188 dbSNP
rs1195541838 189 dbSNP
rs955401645 189 dbSNP
rs1283929963 190 dbSNP
rs547057591 191 dbSNP
rs1162918876 194 dbSNP
rs1347657494 199 dbSNP
rs1018448557 200 dbSNP
rs752269452 201 dbSNP
rs1279549834 205 dbSNP
rs1325478508 209 dbSNP
rs1315868214 211 dbSNP
rs1005946360 213 dbSNP
rs1311325236 220 dbSNP
rs879409189 221 dbSNP
rs1175560609 222 dbSNP
rs1016041067 223 dbSNP
rs1427207269 223 dbSNP
rs1243778787 227 dbSNP
rs1475816038 228 dbSNP
rs747547655 235 dbSNP
rs565384481 239 dbSNP
rs914273274 257 dbSNP
rs372557668 267 dbSNP
rs1244152480 269 dbSNP
rs1358243278 273 dbSNP
rs967021187 277 dbSNP
rs536132061 279 dbSNP
rs1203518639 289 dbSNP
rs1460384559 296 dbSNP
rs977688961 297 dbSNP
rs1035398553 298 dbSNP
rs1338227950 299 dbSNP
rs769740487 308 dbSNP
rs1246565454 312 dbSNP
rs1383202023 315 dbSNP
rs1335844511 318 dbSNP
rs1458246214 319 dbSNP
rs1402351472 320 dbSNP
rs938858776 326 dbSNP
rs1410569592 328 dbSNP
rs1418953151 330 dbSNP
rs1166317628 333 dbSNP
rs1241823426 334 dbSNP
rs1386193614 335 dbSNP
rs1183358330 336 dbSNP
rs1055931535 339 dbSNP
rs148015830 344 dbSNP
rs916062253 345 dbSNP
rs372771766 355 dbSNP
rs757803803 360 dbSNP
rs1270315105 362 dbSNP
rs557506004 369 dbSNP
rs1224167721 374 dbSNP
rs1370519631 376 dbSNP
rs1313998477 377 dbSNP
rs1243492427 379 dbSNP
rs1375303777 385 dbSNP
rs1474641685 386 dbSNP
rs141676377 387 dbSNP
rs1441415925 388 dbSNP
rs1326952351 396 dbSNP
rs576263920 396 dbSNP
rs978775046 399 dbSNP
rs10490929 405 dbSNP
rs934778210 408 dbSNP
rs770682532 413 dbSNP
rs751438818 416 dbSNP
rs545226559 421 dbSNP
rs558749472 427 dbSNP
rs1230616251 439 dbSNP
rs1200941978 441 dbSNP
rs1403282869 446 dbSNP
rs1290538629 447 dbSNP
rs1395317276 450 dbSNP
rs1334774289 459 dbSNP
rs751287339 460 dbSNP
rs1223089115 464 dbSNP
rs1371080671 466 dbSNP
rs1050023742 473 dbSNP
rs764154897 475 dbSNP
rs891010652 476 dbSNP
rs888590828 478 dbSNP
rs1318944106 490 dbSNP
rs1220714578 507 dbSNP
rs1005726818 509 dbSNP
rs1008478309 512 dbSNP
rs1037421914 514 dbSNP
rs1261268077 521 dbSNP
rs897572656 523 dbSNP
rs1344443718 531 dbSNP
rs1406418586 535 dbSNP
rs1179258408 546 dbSNP
rs1480463368 547 dbSNP
rs1018143873 548 dbSNP
rs578016060 549 dbSNP
rs1258932230 556 dbSNP
rs1011358204 560 dbSNP
rs1445604833 560 dbSNP
rs1214803202 578 dbSNP
rs1314955854 581 dbSNP
rs959764334 583 dbSNP
rs1224072312 595 dbSNP
rs1013224072 597 dbSNP
rs1282732899 607 dbSNP
rs1021362306 614 dbSNP
rs1385245337 617 dbSNP
rs545530040 618 dbSNP
rs554197098 619 dbSNP
rs968486053 621 dbSNP
rs1386964660 664 dbSNP
rs1477910188 664 dbSNP
rs572478347 666 dbSNP
rs779902468 683 dbSNP
rs924486432 685 dbSNP
rs1465152585 689 dbSNP
rs543300078 690 dbSNP
rs977052872 693 dbSNP
rs1460827867 699 dbSNP
rs1261240722 709 dbSNP
rs1035948752 710 dbSNP
rs960358923 721 dbSNP
rs1404353651 733 dbSNP
rs992144165 738 dbSNP
rs922565075 744 dbSNP
rs1380301534 745 dbSNP
rs932688490 745 dbSNP
rs1050394155 746 dbSNP
rs761785169 758 dbSNP
rs757171412 763 dbSNP
rs942176103 768 dbSNP
rs1354639105 772 dbSNP
rs1169262155 784 dbSNP
rs1426375949 792 dbSNP
rs1386800930 795 dbSNP
rs781030918 808 dbSNP
rs1037202411 816 dbSNP
rs1311653716 819 dbSNP
rs561593395 826 dbSNP
rs1197533249 827 dbSNP
rs1481627838 833 dbSNP
rs1234102574 834 dbSNP
rs919313183 838 dbSNP
rs150246922 843 dbSNP
rs1216536451 848 dbSNP
rs1287104188 857 dbSNP
rs1051676478 878 dbSNP
rs765910902 880 dbSNP
rs368007808 894 dbSNP
rs1393677544 906 dbSNP
rs1056898093 913 dbSNP
rs890447385 915 dbSNP
rs1195368752 916 dbSNP
rs944001396 918 dbSNP
rs1366517013 920 dbSNP
rs895429753 927 dbSNP
rs543641138 930 dbSNP
rs565504535 948 dbSNP
rs532107211 949 dbSNP
rs1419604300 954 dbSNP
rs193087933 957 dbSNP
rs1176674156 963 dbSNP
rs1023085106 966 dbSNP
rs1432088426 966 dbSNP
rs899686437 970 dbSNP
rs139194135 982 dbSNP
rs1359120307 999 dbSNP
rs1264058737 1004 dbSNP
rs1000091758 1006 dbSNP
rs1451458535 1008 dbSNP
rs1021394780 1015 dbSNP
rs1407417430 1044 dbSNP
rs867590934 1047 dbSNP
rs750924978 1053 dbSNP
rs1346896261 1054 dbSNP
rs1360881935 1062 dbSNP
rs558887645 1066 dbSNP
rs1403985388 1068 dbSNP
rs998602305 1069 dbSNP
rs1388226466 1070 dbSNP
rs756408290 1073 dbSNP
rs1035398561 1076 dbSNP
rs529662984 1087 dbSNP
rs959963490 1088 dbSNP
rs955885085 1089 dbSNP
rs977217364 1091 dbSNP
rs1029749915 1093 dbSNP
rs548046079 1094 dbSNP
rs1303426402 1100 dbSNP
rs1334060914 1101 dbSNP
rs1023613488 1106 dbSNP
rs543079565 1122 dbSNP
rs560108230 1122 dbSNP
rs1260624122 1123 dbSNP
rs963525401 1136 dbSNP
rs1325014578 1145 dbSNP
rs1283370619 1148 dbSNP
rs1356260880 1149 dbSNP
rs973506699 1150 dbSNP
rs919343124 1152 dbSNP
rs569833931 1156 dbSNP
rs1319951695 1159 dbSNP
rs1382552596 1160 dbSNP
rs1384004181 1161 dbSNP
rs1318415103 1162 dbSNP
rs1470918916 1164 dbSNP
rs909925586 1169 dbSNP
rs1177232734 1174 dbSNP
rs1477780518 1175 dbSNP
rs537379641 1177 dbSNP
rs1195662201 1178 dbSNP
rs1447889558 1180 dbSNP
rs1247827748 1186 dbSNP
rs1207311094 1189 dbSNP
rs987508154 1209 dbSNP
rs1264368155 1217 dbSNP
rs1222369415 1222 dbSNP
rs1220806577 1242 dbSNP
rs1263302987 1248 dbSNP
rs1487922779 1252 dbSNP
rs1227749871 1256 dbSNP
rs911925035 1266 dbSNP
rs758879793 1277 dbSNP
rs943345484 1286 dbSNP
rs558467348 1295 dbSNP
rs557024351 1298 dbSNP
rs941576318 1305 dbSNP
rs973011522 1307 dbSNP
rs185686910 1310 dbSNP
rs1413953422 1315 dbSNP
rs1177904104 1325 dbSNP
rs780090755 1326 dbSNP
rs563136140 1338 dbSNP
rs899714797 1339 dbSNP
rs780585772 1341 dbSNP
rs749418349 1342 dbSNP
rs768553410 1351 dbSNP
rs1389876753 1352 dbSNP
rs1187051990 1368 dbSNP
rs149726475 1374 dbSNP
rs775014778 1381 dbSNP
rs903013536 1389 dbSNP
rs1349102002 1391 dbSNP
rs895557193 1392 dbSNP
rs1440158869 1395 dbSNP
rs998636511 1413 dbSNP
rs1195961672 1427 dbSNP
rs1295535366 1433 dbSNP
rs1295037203 1439 dbSNP
rs1247864188 1460 dbSNP
rs1057267484 1469 dbSNP
rs895503049 1473 dbSNP
rs1012965608 1480 dbSNP
rs1446185723 1481 dbSNP
rs1023222803 1489 dbSNP
rs904225357 1497 dbSNP
rs1330991511 1503 dbSNP
rs1445771236 1503 dbSNP
rs1410661948 1527 dbSNP
rs1370177894 1532 dbSNP
rs963556446 1532 dbSNP
rs1166989866 1536 dbSNP
rs995045758 1538 dbSNP
rs1000039961 1539 dbSNP
rs1181720651 1539 dbSNP
rs570665201 1542 dbSNP
rs950871634 1557 dbSNP
rs118189529 1558 dbSNP
rs1482466976 1567 dbSNP
rs1322734733 1592 dbSNP
rs911939246 1598 dbSNP
rs1224275379 1600 dbSNP
rs1359835928 1607 dbSNP
rs954153660 1619 dbSNP
rs2839667 1632 dbSNP
rs191505587 1638 dbSNP
rs962720410 1648 dbSNP
rs1456042518 1655 dbSNP
rs972958923 1656 dbSNP
rs915243405 1657 dbSNP
rs1197529099 1665 dbSNP
rs918848700 1666 dbSNP
rs1366521512 1668 dbSNP
rs777727823 1672 dbSNP
rs992334445 1673 dbSNP
rs543062274 1682 dbSNP
rs1159704709 1700 dbSNP
rs916756091 1709 dbSNP
rs7349 1714 dbSNP
rs924465489 1719 dbSNP
rs1201050377 1726 dbSNP
rs1044136892 1731 dbSNP
rs1245824764 1732 dbSNP
rs934459286 1733 dbSNP
rs1056896722 1734 dbSNP
rs895520254 1738 dbSNP
rs1012584032 1739 dbSNP
rs576641326 1748 dbSNP
rs1167140905 1749 dbSNP
rs1421844013 1755 dbSNP
rs770807325 1758 dbSNP
rs1225493295 1763 dbSNP
rs1044492240 1769 dbSNP
rs1293205192 1773 dbSNP
rs898827705 1774 dbSNP
rs1052933897 1776 dbSNP
rs183651581 1782 dbSNP
rs1319509564 1783 dbSNP
rs1249755259 1785 dbSNP
rs188702835 1786 dbSNP
rs1409050603 1803 dbSNP
rs1177946501 1806 dbSNP
rs1302803028 1808 dbSNP
rs1480516080 1810 dbSNP
rs995078637 1820 dbSNP
rs1380327206 1824 dbSNP
rs1486695128 1828 dbSNP
rs565329122 1844 dbSNP
rs1242492753 1846 dbSNP
rs1026505037 1849 dbSNP
rs1463478750 1861 dbSNP
rs950902247 1864 dbSNP
rs1205612555 1868 dbSNP
rs889647586 1890 dbSNP
rs1009447866 1904 dbSNP
rs1006950142 1921 dbSNP
rs1364440875 1924 dbSNP
rs1315736701 1932 dbSNP
rs1298813603 1933 dbSNP
rs1434897567 1935 dbSNP
rs1019033217 1937 dbSNP
rs965197786 1951 dbSNP
rs1017051180 1959 dbSNP
rs1258063430 1959 dbSNP
rs962666740 1966 dbSNP
rs77992406 1967 dbSNP
rs1025688835 1974 dbSNP
rs764970560 1990 dbSNP
rs1236883966 1992 dbSNP
rs1429946071 1996 dbSNP
rs1419862026 1997 dbSNP
rs1187693393 1999 dbSNP
rs780220921 2000 dbSNP
rs915276261 2004 dbSNP
rs968024834 2006 dbSNP
rs1244874100 2013 dbSNP
rs1184159979 2018 dbSNP
rs75678706 2019 dbSNP
rs759192803 2040 dbSNP
rs559036177 2041 dbSNP
rs1208209250 2044 dbSNP
rs573764915 2046 dbSNP
rs924495136 2060 dbSNP
rs201215623 2061 dbSNP
rs1228084926 2069 dbSNP
rs1477579171 2077 dbSNP
rs1317715449 2079 dbSNP
rs934518039 2086 dbSNP
rs563050681 2088 dbSNP
rs1300555401 2092 dbSNP
rs529773529 2095 dbSNP
rs1370756344 2102 dbSNP
rs948507428 2123 dbSNP
rs1167632785 2128 dbSNP
rs1427532208 2135 dbSNP
rs143336093 2140 dbSNP
rs898858947 2144 dbSNP
rs1175932450 2147 dbSNP
rs1184058714 2150 dbSNP
rs930288062 2158 dbSNP
rs1254066078 2160 dbSNP
rs1360319968 2168 dbSNP
rs563340936 2169 dbSNP
rs75717753 2170 dbSNP
rs1052719221 2171 dbSNP
rs1204732357 2177 dbSNP
rs1340428784 2179 dbSNP
rs1294420711 2188 dbSNP
rs1246064025 2196 dbSNP
rs552452896 2206 dbSNP
rs755032569 2206 dbSNP
rs147527127 2214 dbSNP
rs1392607729 2215 dbSNP
rs200534090 2216 dbSNP
rs1009150280 2238 dbSNP
rs1407621430 2246 dbSNP
rs1051468539 2247 dbSNP
rs1341813524 2253 dbSNP
rs1163605753 2265 dbSNP
rs1457275712 2299 dbSNP
rs774936502 2308 dbSNP
rs1161262915 2318 dbSNP
rs181434712 2334 dbSNP
rs1412834367 2339 dbSNP
rs1038242717 2345 dbSNP
rs996690651 2352 dbSNP
rs898576787 2366 dbSNP
rs994275735 2368 dbSNP
rs220071 2372 dbSNP
rs1264155565 2375 dbSNP
rs968056010 2385 dbSNP
rs978054726 2388 dbSNP
rs1287178801 2395 dbSNP
rs1226098303 2405 dbSNP
rs1283566222 2413 dbSNP
rs184147533 2416 dbSNP
rs1323849921 2417 dbSNP
rs190131604 2421 dbSNP
rs1388334477 2424 dbSNP
rs1290515105 2425 dbSNP
rs1457707308 2425 dbSNP
rs1194625134 2433 dbSNP
rs1265661124 2434 dbSNP
rs1477081581 2437 dbSNP
rs992748918 2439 dbSNP
rs1425979741 2440 dbSNP
rs1411228615 2447 dbSNP
rs552396645 2459 dbSNP
rs1416593338 2461 dbSNP
rs536775108 2468 dbSNP
rs757226187 2471 dbSNP
rs917098446 2472 dbSNP
rs979562821 2473 dbSNP
rs765198767 2474 dbSNP
rs1379568341 2477 dbSNP
rs1157418859 2478 dbSNP
rs1432929160 2486 dbSNP
rs1265718201 2487 dbSNP
rs1360235703 2493 dbSNP
rs1211066984 2499 dbSNP
rs1465731023 2502 dbSNP
rs1420747146 2512 dbSNP
rs1268119740 2514 dbSNP
rs1491155217 2515 dbSNP
rs1491358153 2516 dbSNP
rs925494532 2518 dbSNP
rs1275024632 2524 dbSNP
rs1232114838 2531 dbSNP
rs1329071177 2541 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions MCF-10A
Disease 0.0
Location of target site 3'UTR
Tools used in this research miRanda , PicTar , TargetScan
Original Description (Extracted from the article) ... "Mimics of miR-300 ...

- Haga CL; Phinney DG, 2012, The Journal of biological chemistry.

Article - Haga CL; Phinney DG
- The Journal of biological chemistry, 2012
Development of metastatic disease accounts for the vast majority of cancer-related deaths. Nevertheless, few treatments exist that are designed to specifically inhibit processes that drive tumor metastasis. The imprinted DLK1-DIO3 region contains tumor-suppressing miRNAs, but their identity and function remain indeterminate. In this study we identify seven miRNAs in the imprinted DLK1-DIO3 region that function cooperatively to repress the epithelial-to-mesenchymal transition, a critical step that drives tumor metastasis, as well as proliferation of carcinoma cells. These seven miRNAs (miRs 300, 382, 494, 495, 539, 543, and 544) repress a signaling network comprising TWIST1, BMI1, ZEB1/2, and miR-200 family miRNAs and silencing of the cluster, which occurs via hypermethylation of upstream CpG islands in human ductal carcinomas, confers morphological, molecular, and function changes consistent with an epithelial-to-mesenchymal transition. Moreover, ectopic expression of miR-544 independently inhibited proliferation of numerous tumor cell lines by inducing the ATM cell cycle checkpoint pathway. These results establish the DLKI-DIO3 miRNA cluster as a critical checkpoint regulating tumor growth and metastasis and implicate epigenetic modification of the cluster in driving tumor progression. These results also suggest that promoter methylation status and miRNA expression levels represent new diagnostic tools and therapeutic targets to predict and inhibit, respectively, tumor metastasis in carcinoma patients.
LinkOut: [PMID: 23105110]
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE42095 Differentiated embryonic stem cells 0.71 7.4e-5 0.580 1.9e-3 23 Click to see details
GSE19783 ER- ER- breast cancer 0.365 4.7e-4 0.345 9.2e-4 79 Click to see details
GSE28260 Renal cortex and medulla 0.791 6.4e-4 0.681 5.2e-3 13 Click to see details
GSE19536 Breast cancer 0.268 3.5e-3 0.321 5.6e-4 100 Click to see details
GSE15076 Monocyte-derived dendritic cells 0.898 7.5e-3 0.771 3.6e-2 6 Click to see details
GSE35602 Colorectal cancer stromal tissue 0.382 3.0e-2 0.439 1.4e-2 25 Click to see details
GSE17306 Multiple myeloma 0.205 7.9e-2 0.283 2.4e-2 49 Click to see details
GSE21849 B cell lymphoma -0.265 8.2e-2 -0.197 1.5e-1 29 Click to see details
GSE27834 Pluripotent stem cells 0.338 1.0e-1 0.453 3.9e-2 16 Click to see details
GSE14794 Lymphoblastoid cells -0.075 2.4e-1 -0.051 3.2e-1 90 Click to see details
GSE21687 Ependynoma primary tumors -0.085 2.5e-1 -0.073 2.8e-1 64 Click to see details
GSE38974 Chronic obstructive pulmonary disease -0.126 2.7e-1 -0.127 2.7e-1 25 Click to see details
GSE19350 CNS germ cell tumors 0.174 2.9e-1 0.175 2.9e-1 12 Click to see details
GSE21032 Prostate cancer -0.059 3.0e-1 -0.124 1.3e-1 83 Click to see details
GSE17498 Multiple myeloma 0.086 3.0e-1 0.123 2.2e-1 40 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis -0.102 3.3e-1 -0.012 4.8e-1 20 Click to see details
GSE38226 Liver fibrosis -0.087 3.5e-1 0.047 4.2e-1 21 Click to see details
GSE19783 ER+ ER+ breast cancer 0.076 3.8e-1 0.211 1.9e-1 20 Click to see details
GSE28544 Breast cancer -0.059 3.9e-1 0.068 3.8e-1 24 Click to see details
GSE26953 Aortic valvular endothelial cells -0.05 4.1e-1 0.042 4.2e-1 24 Click to see details
GSE32688 Pancreatic cancer 0.021 4.5e-1 0.055 3.8e-1 32 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
KIRC 0.303 0.01 0.295 0.01 66 Click to see details
BLCA -0.516 0.01 -0.507 0.02 18 Click to see details
STAD -0.373 0.02 -0.467 0 31 Click to see details
KICH 0.385 0.03 0.148 0.25 23 Click to see details
HNSC 0.27 0.04 0.267 0.04 42 Click to see details
COAD -0.582 0.07 -0.571 0.07 8 Click to see details
LIHC 0.19 0.1 0.151 0.15 48 Click to see details
PAAD 0.769 0.12 0.800 0.1 4 Click to see details
LUAD 0.44 0.16 0.286 0.27 7 Click to see details
CHOL 0.348 0.18 0.150 0.35 9 Click to see details
THCA -0.105 0.23 -0.094 0.26 50 Click to see details
KIRP 0.108 0.28 0.158 0.2 30 Click to see details
UCEC -0.138 0.29 -0.053 0.41 19 Click to see details
BRCA 0.043 0.35 0.052 0.32 84 Click to see details
CESC -0.447 0.35 -0.500 0.33 3 Click to see details
PRAD 0.028 0.43 0.042 0.39 47 Click to see details
LUSC -0.027 0.44 -0.016 0.46 37 Click to see details
ESCA -0.014 0.48 -0.091 0.4 11 Click to see details
PCPG -0.03 0.49 -0.500 0.33 3 Click to see details
PCPG -0.03 0.49 -0.500 0.33 3 Click to see details
PCPG -0.03 0.49 -0.500 0.33 3 Click to see details
193 hsa-miR-539-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT053510 TWIST1 twist family bHLH transcription factor 1 4 1
MIRT053516 ZEB1 zinc finger E-box binding homeobox 1 4 1
MIRT057687 LCOR ligand dependent nuclear receptor corepressor 2 8
MIRT066722 CCT2 chaperonin containing TCP1 subunit 2 2 6
MIRT071515 CALM1 calmodulin 1 1 1
MIRT084964 BACH1 BTB domain and CNC homolog 1 2 2
MIRT096759 GPBP1 GC-rich promoter binding protein 1 2 2
MIRT099799 SOX4 SRY-box 4 2 2
MIRT126502 OTUD1 OTU deubiquitinase 1 2 2
MIRT163869 WDR1 WD repeat domain 1 2 2
MIRT176316 DDX3Y DEAD-box helicase 3, Y-linked 2 2
MIRT182188 POU2F1 POU class 2 homeobox 1 2 4
MIRT234348 MSL1 male specific lethal 1 homolog 2 8
MIRT244630 YTHDF3 YTH N6-methyladenosine RNA binding protein 3 2 4
MIRT262597 ZNF37A zinc finger protein 37A 2 2
MIRT282630 IGF1R insulin like growth factor 1 receptor 2 2
MIRT287286 PSME3 proteasome activator subunit 3 2 2
MIRT310569 DCK deoxycytidine kinase 2 4
MIRT335358 PEBP1 phosphatidylethanolamine binding protein 1 1 1
MIRT367797 PRRG4 proline rich and Gla domain 4 2 2
MIRT439294 WASF3 WAS protein family member 3 2 3
MIRT439373 TULP3 tubby like protein 3 1 1
MIRT439515 STT3A STT3A, catalytic subunit of the oligosaccharyltransferase complex 1 1
MIRT439603 SLC39A6 solute carrier family 39 member 6 1 1
MIRT439659 SFMBT2 Scm like with four mbt domains 2 1 1
MIRT439661 SF3B1 splicing factor 3b subunit 1 1 1
MIRT439664 SETX senataxin 1 1
MIRT439728 RPS4X ribosomal protein S4, X-linked 1 1
MIRT440082 NUCB2 nucleobindin 2 1 1
MIRT440321 LOC728392 uncharacterized LOC728392 1 1
MIRT440354 KLHL2 kelch like family member 2 1 1
MIRT440371 KIF21A kinesin family member 21A 1 1
MIRT440412 KAT2B lysine acetyltransferase 2B 1 1
MIRT440606 FXR2 FMR1 autosomal homolog 2 1 1
MIRT440789 DNMT3A DNA methyltransferase 3 alpha 1 1
MIRT440803 DNAJB9 DnaJ heat shock protein family (Hsp40) member B9 1 1
MIRT440919 CNOT4 CCR4-NOT transcription complex subunit 4 1 1
MIRT440975 CDC27 cell division cycle 27 1 1
MIRT441206 ARFGEF2 ADP ribosylation factor guanine nucleotide exchange factor 2 1 1
MIRT441291 ACPP acid phosphatase, prostate 1 1
MIRT441634 KDM5A lysine demethylase 5A 2 2
MIRT442560 CAB39 calcium binding protein 39 2 2
MIRT443087 PTPRN2 protein tyrosine phosphatase, receptor type N2 2 2
MIRT443454 CLIC5 chloride intracellular channel 5 2 2
MIRT443721 TAF1B TATA-box binding protein associated factor, RNA polymerase I subunit B 2 2
MIRT443772 STS steroid sulfatase 2 2
MIRT444081 C12orf73 chromosome 12 open reading frame 73 2 2
MIRT444548 UBE2D3 ubiquitin conjugating enzyme E2 D3 2 2
MIRT444564 TRA2B transformer 2 beta homolog 2 2
MIRT444723 LAMA2 laminin subunit alpha 2 2 2
MIRT444958 ADAM22 ADAM metallopeptidase domain 22 2 2
MIRT445051 SLC16A9 solute carrier family 16 member 9 2 2
MIRT445143 IKBIP IKBKB interacting protein 2 2
MIRT445415 ACSL6 acyl-CoA synthetase long chain family member 6 2 2
MIRT445620 CLIC4 chloride intracellular channel 4 2 2
MIRT445967 IKZF5 IKAROS family zinc finger 5 2 2
MIRT446159 RPL12 ribosomal protein L12 2 2
MIRT446231 C17orf80 chromosome 17 open reading frame 80 2 2
MIRT446392 HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 2 2
MIRT446944 ZMAT3 zinc finger matrin-type 3 2 2
MIRT447194 CDCP1 CUB domain containing protein 1 2 2
MIRT447360 FAM161B family with sequence similarity 161 member B 2 2
MIRT447793 RCBTB1 RCC1 and BTB domain containing protein 1 2 2
MIRT447830 CTIF cap binding complex dependent translation initiation factor 2 2
MIRT448123 CCDC80 coiled-coil domain containing 80 2 2
MIRT448401 TNRC6C trinucleotide repeat containing 6C 2 2
MIRT448720 ITGA2 integrin subunit alpha 2 2 2
MIRT448800 GLIS3 GLIS family zinc finger 3 2 2
MIRT449070 CNDP2 carnosine dipeptidase 2 2 2
MIRT449122 XRRA1 X-ray radiation resistance associated 1 2 2
MIRT449412 TRIM5 tripartite motif containing 5 2 2
MIRT449712 TSPYL1 TSPY like 1 2 2
MIRT449845 BCL2L13 BCL2 like 13 2 2
MIRT449944 IGF1 insulin like growth factor 1 2 2
MIRT450088 OR2A4 olfactory receptor family 2 subfamily A member 4 2 2
MIRT450808 NUFIP2 NUFIP2, FMR1 interacting protein 2 2 6
MIRT451876 SOD2 superoxide dismutase 2 2 8
MIRT452003 FKBP5 FK506 binding protein 5 2 2
MIRT452244 TRAM1 translocation associated membrane protein 1 2 2
MIRT453892 DUSP18 dual specificity phosphatase 18 2 2
MIRT457507 SLC35F6 solute carrier family 35 member F6 2 2
MIRT458522 C5orf22 chromosome 5 open reading frame 22 2 2
MIRT459799 POTED POTE ankyrin domain family member D 2 10
MIRT459869 KIAA1191 KIAA1191 2 2
MIRT460004 DNALI1 dynein axonemal light intermediate chain 1 2 2
MIRT464765 UBE2G1 ubiquitin conjugating enzyme E2 G1 2 2
MIRT464933 TXLNA taxilin alpha 2 2
MIRT465140 TSC22D2 TSC22 domain family member 2 2 2
MIRT469364 REST RE1 silencing transcription factor 2 6
MIRT474820 KIAA0226 RUN and cysteine rich domain containing beclin 1 interacting protein 2 2
MIRT475668 HIATL1 major facilitator superfamily domain containing 14B 2 4
MIRT476144 GPR137C G protein-coupled receptor 137C 2 8
MIRT478054 DNAJC10 DnaJ heat shock protein family (Hsp40) member C10 2 8
MIRT478588 CTDSPL2 CTD small phosphatase like 2 2 2
MIRT478805 CRTAP cartilage associated protein 2 2
MIRT479295 CHAC1 ChaC glutathione specific gamma-glutamylcyclotransferase 1 2 2
MIRT481480 ARL8B ADP ribosylation factor like GTPase 8B 2 2
MIRT484232 IER2 immediate early response 2 2 2
MIRT485424 LDLR low density lipoprotein receptor 2 6
MIRT486920 CSTF2 cleavage stimulation factor subunit 2 2 4
MIRT488396 PDE4DIP phosphodiesterase 4D interacting protein 2 2
MIRT488426 COPA coatomer protein complex subunit alpha 2 2
MIRT489553 SOX11 SRY-box 11 2 6
MIRT493068 MTCH1 mitochondrial carrier 1 2 2
MIRT494096 DPY19L1 dpy-19 like C-mannosyltransferase 1 2 2
MIRT497894 STRN striatin 2 2
MIRT498084 SETD5 SET domain containing 5 2 2
MIRT499923 GPX8 glutathione peroxidase 8 (putative) 2 2
MIRT501618 PISD phosphatidylserine decarboxylase 2 2
MIRT501835 NCOA2 nuclear receptor coactivator 2 2 2
MIRT502043 LAMTOR1 late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 2 6
MIRT502255 HNRNPF heterogeneous nuclear ribonucleoprotein F 2 2
MIRT502327 GIGYF1 GRB10 interacting GYF protein 1 2 2
MIRT502991 CCDC71L coiled-coil domain containing 71 like 2 8
MIRT505415 TCF7L2 transcription factor 7 like 2 2 4
MIRT505694 SESN3 sestrin 3 2 2
MIRT506325 ONECUT2 one cut homeobox 2 2 2
MIRT506331 NUPL2 nucleoporin like 2 2 4
MIRT506877 KIAA0101 PCNA clamp associated factor 2 6
MIRT508237 ZNF121 zinc finger protein 121 2 4
MIRT509849 MSANTD4 Myb/SANT DNA binding domain containing 4 with coiled-coils 2 6
MIRT510002 UCP1 uncoupling protein 1 2 6
MIRT510324 SLC2A3 solute carrier family 2 member 3 2 4
MIRT511449 HNRNPU heterogeneous nuclear ribonucleoprotein U 2 6
MIRT512379 PHB2 prohibitin 2 2 2
MIRT513672 SMG1 SMG1, nonsense mediated mRNA decay associated PI3K related kinase 2 4
MIRT516479 RAB32 RAB32, member RAS oncogene family 2 4
MIRT517589 ZNF579 zinc finger protein 579 2 4
MIRT520501 TRAM2 translocation associated membrane protein 2 2 6
MIRT521656 PRKD3 protein kinase D3 2 2
MIRT524646 C4orf32 family with sequence similarity 241 member A 2 2
MIRT528365 ZMYM1 zinc finger MYM-type containing 1 2 4
MIRT530455 SULT1B1 sulfotransferase family 1B member 1 2 2
MIRT537168 GGA2 golgi associated, gamma adaptin ear containing, ARF binding protein 2 2 2
MIRT537761 ELAVL2 ELAV like RNA binding protein 2 2 2
MIRT537959 DPYSL2 dihydropyrimidinase like 2 2 2
MIRT539317 AHSA2 activator of HSP90 ATPase homolog 2 2 2
MIRT539610 SHISA9 shisa family member 9 2 2
MIRT539641 BUB1 BUB1 mitotic checkpoint serine/threonine kinase 2 2
MIRT540335 OPHN1 oligophrenin 1 2 2
MIRT543806 COCH cochlin 2 2
MIRT544135 GLO1 glyoxalase I 2 4
MIRT544497 SLC25A46 solute carrier family 25 member 46 2 2
MIRT544792 ZKSCAN8 zinc finger with KRAB and SCAN domains 8 2 2
MIRT545832 ZNF367 zinc finger protein 367 2 4
MIRT546461 SLC39A14 solute carrier family 39 member 14 2 2
MIRT546578 SAR1A secretion associated Ras related GTPase 1A 2 2
MIRT548379 ENPP5 ectonucleotide pyrophosphatase/phosphodiesterase 5 (putative) 2 4
MIRT549858 MCM4 minichromosome maintenance complex component 4 2 2
MIRT550705 TP53RK TP53 regulating kinase 2 4
MIRT550839 ABRACL ABRA C-terminal like 2 2
MIRT551955 RNF157 ring finger protein 157 2 2
MIRT552508 ZIK1 zinc finger protein interacting with K protein 1 2 4
MIRT553922 STK11IP serine/threonine kinase 11 interacting protein 2 2
MIRT555151 PTPDC1 protein tyrosine phosphatase domain containing 1 2 2
MIRT555348 PPP1R37 protein phosphatase 1 regulatory subunit 37 2 2
MIRT559946 TRMT112 tRNA methyltransferase subunit 11-2 2 2
MIRT560145 RNPS1 RNA binding protein with serine rich domain 1 2 2
MIRT560848 OSBPL3 oxysterol binding protein like 3 2 2
MIRT561238 ZNF652 zinc finger protein 652 2 2
MIRT562248 GRWD1 glutamate rich WD repeat containing 1 2 2
MIRT563485 ZWINT ZW10 interacting kinetochore protein 2 2
MIRT563872 BASP1 brain abundant membrane attached signal protein 1 2 2
MIRT568196 CBX6 chromobox 6 2 2
MIRT571648 SF1 splicing factor 1 2 2
MIRT574107 SPINT2 serine peptidase inhibitor, Kunitz type 2 2 2
MIRT608237 PARP15 poly(ADP-ribose) polymerase family member 15 2 2
MIRT609337 HRASLS5 HRAS like suppressor family member 5 2 2
MIRT612010 COX17 COX17, cytochrome c oxidase copper chaperone 2 2
MIRT612278 ZNF226 zinc finger protein 226 2 2
MIRT612726 NFAM1 NFAT activating protein with ITAM motif 1 2 4
MIRT623647 HS3ST5 heparan sulfate-glucosamine 3-sulfotransferase 5 2 2
MIRT644590 SPOP speckle type BTB/POZ protein 2 2
MIRT647567 ZNF660 zinc finger protein 660 2 2
MIRT649818 PSMC1 proteasome 26S subunit, ATPase 1 2 2
MIRT650882 PPP1R15A protein phosphatase 1 regulatory subunit 15A 2 2
MIRT654470 RANBP2 RAN binding protein 2 2 2
MIRT662531 PTCD2 pentatricopeptide repeat domain 2 2 2
MIRT667796 JHDM1D lysine demethylase 7A 1 1
MIRT668978 CLCN3 chloride voltage-gated channel 3 2 2
MIRT696546 HIST1H3B histone cluster 1 H3 family member b 2 2
MIRT697819 UBQLN1 ubiquilin 1 2 2
MIRT704048 EDEM3 ER degradation enhancing alpha-mannosidase like protein 3 2 2
MIRT705514 ARL6IP1 ADP ribosylation factor like GTPase 6 interacting protein 1 2 2
MIRT715899 SIPA1L1 signal induced proliferation associated 1 like 1 2 2
MIRT716350 C10orf105 chromosome 10 open reading frame 105 2 2
MIRT716638 DPY19L4 dpy-19 like 4 2 2
MIRT721205 PUS7L pseudouridylate synthase 7 like 2 2
MIRT732106 CDK4 cyclin dependent kinase 4 3 1
MIRT732127 CARD11 caspase recruitment domain family member 11 3 1
MIRT736678 TRIAP1 TP53 regulated inhibitor of apoptosis 1 3 0
MIRT755656 SLC11A2 solute carrier family 11 member 2 3 1
MIRT755660 Irak3 interleukin-1 receptor-associated kinase 3 3 1
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-539 Budesonide approved 5281004 Microarray neonatal mice liver 20145010 2010 up-regulated
miR-539 17beta-estradiol (E2) approved 5757 Microarray rat breast 17700064 2007 down-regulated
miR-539 Dexamethasone approved 5743 Microarray primary rat thymocytes 20847043 2010 up-regulated
miR-539 Longevinex NULL NULL Quantitative real-time PCR ischemia/reperfusion [I/R] rat model 21203465 2011 up-regulated
miR-539 Resveratrol NULL 445154 Quantitative real-time PCR ischemia/reperfusion [I/R] rat model 21203465 2011 down-regulated
miR-539-5p Atorvastatin approved 60823 Microarray PC3 prostate cancer cells 23936432 2013 down-regualted
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-539 Ceritinib 57379345 NSC776422 approved resistant High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-mir-539 Fluorouracil 3385 NSC19893 approved resistant cell line (OE19)
hsa-mir-539 Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)
hsa-miR-539-5p (1-(((2-amino-6-chloro-4-pyrimidinyl)amino)methyl)-3-isopropylcyclobutyl)methanol 385230 NSC676343 sensitive
hsa-miR-539-5p (2S,6S,7S,12R)-16-bromo-9-tert-butyl-4-phenyl-4,20-diazapentacyclo[11.7.0.02,6.07,12.014,19]icosa-1(13),14(19),15,17-tetraene-3,5-dione 372657 NSC648154 sensitive
hsa-miR-539-5p (2Z)-2-(tert-butylhydrazinylidene)-N-(3-chloro-1,4-dioxonaphthalen-2-yl)-3-(3,7,12-trioxo-4H-naphtho[2,3-h]quinoxalin-2-yl)propanamide 5479912 NSC649574 resistant
hsa-miR-539-5p (4S,5R)-4-(2-methylpropyl)-3-[(1R)-1-phenylethyl]-5-phenylmethoxyoxathiazinane 2,2-dioxide 390837 NSC688895 sensitive
hsa-miR-539-5p (5z)-3-[4-benzoyl-2-[(4z)-5-oxo-2-phenyl-4-[(3,4,5-trimethoxyphenyl)methylidene]imidazol-1-yl]phenyl]-2-phenyl-5-[(3,4,5-trimethoxyphenyl)methylidene]imidazol-4-one NSC711885 sensitive
hsa-miR-539-5p (8S,9S,10R,11S,13S,14S,17S)-11-hydroxy-10,13-dimethyl-17-(2-phenyl-1,3-thiazol-4-yl)-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one 261360 NSC93354 sensitive
hsa-miR-539-5p (E)-1-[4-(quinazolin-4-ylamino)phenyl]-3-(2,4,6-trimethoxyphenyl)prop-2-en-1-one 155816064 NSC760015 sensitive
hsa-miR-539-5p (E)-N-ethyl-3-(4-methoxyphenyl)-2-(3,4,5-trimethoxyphenyl)prop-2-enamide 5388754 NSC638409 sensitive
hsa-miR-539-5p (Z)-3-[5-[3,5-bis(trifluoromethyl)phenyl]furan-2-yl]prop-2-enenitrile 5468615 NSC672868 sensitive
hsa-miR-539-5p [(1s,2s,3r,4s,7r,9s,10s,12r,15s)-4,12-diacetyloxy-15-[(2r,3s)-3-benzamido-2-hydroxy-3-(2-methylphenyl)propanoyl]oxy-1,9-dihydroxy-10,14,17,17-tetramethyl-11-oxo-6-oxatetracyclo[11.3.1.03,10.04,7]hepta 383478 NSC671870 sensitive
hsa-miR-539-5p [(3bR,9aS,11aS)-2-(2-hydroxy-5-oxo-2H-furan-3-yl)-3b,6,6,9a-tetramethyl-2,3,3a,4,5,5a,7,8,9,9b,10,11-dodecahydronaphtho[2,1-e][1]benzofuran-11a-yl]methyl acetate 378635 NSC661428 sensitive
hsa-miR-539-5p [(8R,10S,13R)-7,12-diacetyloxy-17-[5,5-bis(4-chlorophenyl)pent-4-en-2-yl]-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl] acetate 376380 NSC657282 sensitive
hsa-miR-539-5p [acetyl-[5-(trityloxymethyl)spiro[3a,5,6,6a-tetrahydrofuro[2,3-d][1,3]dioxole-2,1'-cyclopentane]-6-yl]amino] acetate 374290 NSC651809 sensitive
hsa-miR-539-5p {2-[(benzylamino)methyl]-1h-indole-1,3-diyl}bis(phenylmethanone) 374841 NSC653267 sensitive
hsa-miR-539-5p 1-(9-methoxy-11,12-dihydro-6h-indolo[1,2-b][2]benzazepin-13-yl)ethanone 365697 NSC633551 sensitive
hsa-miR-539-5p 1-(acetyloxy)-2-(2-(1-(acetyloxy)-1h-benzimidazol-2-yl)phenyl)-1h-benzimidazole 355531 NSC609356 sensitive
hsa-miR-539-5p 1-(benzenesulfonyl)-2-[1-(benzenesulfonyl)-3-methylindol-2-yl]-3-methylindole 396901 NSC704080 resistant
hsa-miR-539-5p 1-[10-[4-(dimethylamino)-2-methylquinolin-1-ium-1-yl]decyl]-N,N,2-trimethylquinolin-1-ium-4-amine;perchlorate 387883 NSC682095 sensitive
hsa-miR-539-5p 1-[2-(3-chloropropyl)phenyl]-3,4-dihydroisoquinoline;hydrochloride 390024 NSC686940 sensitive
hsa-miR-539-5p 1-[3-(3,4-dimethoxyphenyl)-2-(2,4-dinitrophenyl)-3,4-dihydropyrazol-5-yl]naphthalen-2-ol 390439 NSC687793 sensitive
hsa-miR-539-5p 1-[5-[[[4-chlorobutyl(methyl)amino]-[(5-nitrofuran-2-yl)methoxy]phosphoryl]oxymethyl]-2,5-dihydrofuran-2-yl]-5-methylpyrimidine-2,4-dione 404846 NSC721390 sensitive
hsa-miR-539-5p 1-benzyl-2-methyl-1-(2-phenylethyl)-4,5-dihydroimidazol-1-ium 413544 NSC49460 sensitive
hsa-miR-539-5p 1-benzyl-3-hexadecyl-2-methylimidazolium chloride 44219704 NSC745343 sensitive
hsa-miR-539-5p 10-methyl-2-[(3,4,5-trimethoxyphenyl)methyl]phenothiazine-1-carbonitrile 374832 NSC653255 sensitive
hsa-miR-539-5p 13-methoxy-6-methyl-2-nitro-6,9,17-triazatetracyclo[8.7.1.05,18.011,16]octadeca-1,3,5(18),10,12,14,16-heptaene 438699 NSC658995 resistant
hsa-miR-539-5p 2-(2-naphthyl)-5,7-dimethyl-1,8-naphthyridin-4(1h)-one 5468909 NSC679021 sensitive
hsa-miR-539-5p 2-(4-chlorophenyl)-1-methylene-3-phenyl-pyrazino[1,2-a]benzimidazole 390230 NSC687522 resistant
hsa-miR-539-5p 2-(6-benzoyl-1h-benzimidazol-2-yl)-3,4,5,6-tetrachloro-n-(furan-2-yl)benzamide 402231 NSC716122 sensitive
hsa-miR-539-5p 2-(hydroxymethyl)-5-[6-(2-propan-2-ylidenehydrazinyl)purin-9-yl]oxolane-3,4-diol 60147745 NSC752330 resistant
hsa-miR-539-5p 2-(trifluoromethyl)benzimidazo[2,1-b][1,3,5]benzothiadiazepin-12(13h)-imine 383194 NSC671313 sensitive
hsa-miR-539-5p 2-[[6-[[bis(carboxymethyl)amino]methyl]-4-[2-[4-(2-phenylethynyl)phenyl]ethynyl]pyridin-2-yl]methyl-(carboxymethyl)amino]acetic acid 369524 NSC641379 resistant
hsa-miR-539-5p 2-[2-[5-(ethoxycarbonylcarbamoyl)-3-methyl-2,4-dioxopyrimidin-1-yl]ethylsulfanyl]ethyl n-[6-[2-[2-[5-(ethoxycarbonylcarbamoyl)-3-methyl-2,4-dioxopyrimidin-1-yl]ethylsulfanyl]ethoxycarbonylamino]hexyl] 367630 NSC637505 sensitive
hsa-miR-539-5p 2-[2-methoxy-5-[(E)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenoxy]acetic acid 5934333 NSC643813 sensitive
hsa-miR-539-5p 2-acetyl-1,2-dihydroellipticine 376328 NSC657149 resistant
hsa-miR-539-5p 2-azaadenine 5480214 NSC57048 resistant
hsa-miR-539-5p 2-ethyl-n-phenyl-5,6,7,8-tetrahydrothieno[2,3-b]quinolin-4-amine 365483 NSC633116 sensitive
hsa-miR-539-5p 2-methyl-1-[10-[(2-methylquinolin-4-yl)amino]decyl]quinolin-1-ium-4-amine;chloride;hydrochloride 387885 NSC682096 sensitive
hsa-miR-539-5p 2-methyl-4,4-diphenyl-1,4-benzoxaphosphinin-4-ium;bromide 24199840 NSC346098 sensitive
hsa-miR-539-5p 2-n-[3-(diethylaminomethyl)-4-methoxyphenyl]-4-n-[4-(dimethylamino)cyclohexyl]quinazoline-2,4-diamine;hydrochloride 54610390 NSC174030 sensitive
hsa-miR-539-5p 2,2'-spirobi[indane]-5,5'-dicarbaldehyde 382743 NSC670421 sensitive
hsa-miR-539-5p 2,2'(1h,1'h)-spirobi[s-indacen]-1-one, 4'-acetyl-3,3',5,5',6,6',7,7'-octahydro- 382664 NSC670312 sensitive
hsa-miR-539-5p 2,3-dibenzoyloxy-4-hydroxy-4-oxobutanoate;(2,5-dimethylphenyl)-(4-methylphenyl)-phenylsulfanium 5351228 NSC116693 sensitive
hsa-miR-539-5p 2,5-dibenzyl-2-undecyloctahydro-1h-pyrrolo[3,4-c]pyridin-2-ium bromide 378731 NSC661832 sensitive
hsa-miR-539-5p 2,5,12-trimethyl-[1,4]benzodioxino[3,2-g]isoquinolin-2-ium acetate 388316 NSC683048 sensitive
hsa-miR-539-5p 2,6,13,17-tetrazaheptacyclo[15.12.0.01,25.03,16.05,14.07,12.018,23]nonacosa-3,5,7,9,11,13,15,18(23)-octaene 378784 NSC661960 sensitive
hsa-miR-539-5p 3-(3-fluorophenyl)-n-pyridin-3-yl-2h-pyrazolo[3,4-d][1,3]thiazol-5-amine 60147811 NSC752461 sensitive
hsa-miR-539-5p 3-(4-methoxyphenyl)-4-methyl-8-pyrrolidin-1-yl-8H-thieno[2,3-b]pyrrolizin-4-ium;iodide 388538 NSC683518 sensitive
hsa-miR-539-5p 3-amino-4-(1,3-benzothiazol-2-yl)-7-nitro-2-(1-phenylethyl)isoquinolin-1-one 391659 NSC691201 sensitive
hsa-miR-539-5p 3-nitro-5-oxo-7h-benzimidazolo[1,2-a]quinoline-6-carbonitrile 391674 NSC691216 sensitive
hsa-miR-539-5p 3,3'-diethyl-9-methylthiacarbocyanine iodide 5351210 NSC96932 sensitive
hsa-miR-539-5p 3,3-bis(3-(trifluoromethyl)phenyl)naphtho[1,2-c]furan-1(3h)-one 362080 NSC625603 sensitive
hsa-miR-539-5p 3,4,7-trichloro-n,n-bis(2-chloroethyl)-11-oxobenzo[d][1,3,6,2]benzodioxathiaphosphocin-11-amine 382835 NSC670664 sensitive
hsa-miR-539-5p 4-(3h-[1,3]thiazolo[3,4-a]benzimidazol-1-yl)phenyl acetate 384820 NSC675272 sensitive
hsa-miR-539-5p 4-(4-carbazol-9-ylbutanoylamino)-n-[5-[3-(dimethylamino)propylcarbamoyl]-1-methylpyrrol-3-yl]-1-methylpyrrole-2-carboxamide 406397 NSC724462 sensitive
hsa-miR-539-5p 4-(5-(4-(hydroxy(oxido)amino)phenyl)-2-furyl)-2-(4-toluidino)-1,3-thiazole 367868 NSC638034 sensitive
hsa-miR-539-5p 4-(bromomethyl)-2,2,5,5-tetramethyl-1-imidazolidinol 3-oxide 378673 NSC661470 resistant
hsa-miR-539-5p 4-[(13R)-13-hydroxy-13-[(2S,5S)-5-[(2S,5S)-5-[1-hydroxy-13-[(2S)-2-methyl-5-oxo-2H-furan-4-yl]tridecyl]oxolan-2-yl]oxolan-2-yl]tridecyl]-2-methyl-2H-furan-5-one 374064 NSC651320 sensitive
hsa-miR-539-5p 4-[(2z)-2-[3-butyl-4-(4-chlorophenyl)-1,3-thiazolidin-2-ylidene]hydrazinyl]-2h-phthalazin-1-one 9572675 NSC724117 sensitive
hsa-miR-539-5p 4-[(e)-2-[3-(4-chlorophenyl)-6a,10b-dimethyl-8-methylidene-1,4a,5,6,7,9,10,10a-octahydronaphtho[2,1-d][1,3]dioxin-7-yl]ethenyl]-2h-furan-5-one 54613025 NSC750038 sensitive
hsa-miR-539-5p 4-[[(4S,9aR)-9-(4-hydroxy-3,5-dimethoxyphenyl)-6,7-dimethoxy-1-oxo-3a,4,9,9a-tetrahydro-3H-benzo[f][2]benzofuran-4-yl]amino]benzonitrile 369961 NSC642328 sensitive
hsa-miR-539-5p 4-[[(Z)-N-benzamido-C-[4-[bis(2-cyanoethyl)amino]-2-methylphenyl]carbonimidoyl]diazenyl]benzoic acid 135493923 NSC681974 sensitive
hsa-miR-539-5p 4-methyl-1,1-diphenyl-1,2,3,4-tetrahydrobenzo(h)phosphinolinium hexafluorophosphate 498151 NSC245398 sensitive
hsa-miR-539-5p 4-naphthalen-2-yl-2,4-dioxo-3-(3-oxo-1H-2-benzofuran-1-yl)-N-[3-(trifluoromethyl)phenyl]butanamide 369471 NSC641241 sensitive
hsa-miR-539-5p 4-pyridin-3-yl-2-(2,3,5-trichlorophenyl)-1,3-thiazole 24814783 NSC742842 resistant
hsa-miR-539-5p 5-(4-chlorophenyl)-3-[3-[(E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoyl]phenyl]-1H-imidazol-2-one 46919707 NSC748559 resistant
hsa-miR-539-5p 5-[(5s,8ar)-5-(4-fluoroanilino)-8-oxo-5a,6,8a,9-tetrahydro-5h-[2]benzofuro[6,5-f][1,3]benzodioxol-9-yl]-3-methoxycyclohexa-3,5-diene-1,2-dione 369957 NSC642324 sensitive
hsa-miR-539-5p 5-benzyl-5h-benzo[b]phosphindole 5-oxide 380786 NSC666496 sensitive
hsa-miR-539-5p 5-chroman-6-yl-2-(4-pyridyl)oxazole 380226 NSC665702 sensitive
hsa-miR-539-5p 5-hydroxy-3,7-dimethoxy-3',4'-methylenedioxyflavone 5466137 NSC678102 sensitive
hsa-miR-539-5p 5-methyl-2-{[(2)-3-phenylprop-2-enoyl]amino}benzamide 53329052 NSC748147 sensitive
hsa-miR-539-5p 5,10-dihydroxy-3-[[4-(2-hydroxyethyl)piperazin-1-yl]methyl]-1H-naphtho[2,3-f]indole-4,11-dione;hydrochloride 135585401 NSC726442 resistant
hsa-miR-539-5p 7'-but-3-en-2-yl-7'-(3-phenylmethoxypropyl)spiro[1,3-dioxolane-2,2'-3,4,7a,8,9,10-hexahydro-1h-cyclopenta[i]indolizine]-6'-thione 361486 NSC624523 sensitive
hsa-miR-539-5p 7-[(3-fluorophenyl)methoxy]-9-[(3-fluorophenyl)methyl]-2-[(4-fluorophenyl)methyl]-1-methylpyrido[3,4-b]indol-2-ium 54766740 NSC760181 sensitive
hsa-miR-539-5p 7-epi-3,4-bis-nor-dolastatin 11 396354 NSC702158 sensitive
hsa-miR-539-5p 8-(6-fluorohexyl)-3-methyl-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one;hydrochloride 380336 NSC665863 resistant
hsa-miR-539-5p 8-[3-(1,3-dioxolan-2-yl)-2-(4-fluorophenyl)propyl]-3-ethyl-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one;hydrochloride 380308 NSC665789 resistant
hsa-miR-539-5p 8-aminoadenosine 259812 NSC90394 resistant
hsa-miR-539-5p 8-benzyl-12-[2-(4-chloroanilino)-2-oxoethyl]sulfanyl-5-methyl-7-oxo-3-thia-1,8,10,11-tetrazatricyclo[7.3.0.02,6]dodeca-2(6),4,9,11-tetraene-4-carboxamide 155805059 NSC762858 sensitive
hsa-miR-539-5p 8b-hydroxy-9b,10b-epoxyverrucarin a 5351311 NSC328166 sensitive
hsa-miR-539-5p 9-((2-chloroethyl)thio)acridine 395387 NSC699923 resistant
hsa-miR-539-5p 9-bromo-2,3-dimethoxy-7,12-dihydro-5H-indolo[3,2-d][1]benzazepin-6-one 395805 NSC700693 resistant
hsa-miR-539-5p 9-chloro-12,13-dimethoxy-6-phenyl-2,10-diazatetracyclo[6.6.2.04,16.011,15]hexadeca-1(14),4(16),5,7,9,11(15),12-heptaen-3-one 5470922 NSC706236 resistant
hsa-miR-539-5p Baccharin 5358645 NSC269757 sensitive
hsa-miR-539-5p Berberine iodide 72350 NSC150446 sensitive
hsa-miR-539-5p Bis(trifluoromethylsulfonyl)azanide;trihexyl(tetradecyl)phosphanium 11181836 NSC747251 sensitive
hsa-miR-539-5p Blastmycin 245869 NSC58239 sensitive
hsa-miR-539-5p C12h8n2o2s 3838042 NSC675587 sensitive
hsa-miR-539-5p C22h12f6o6s2 389883 NSC686511 sensitive
hsa-miR-539-5p Carbon monoxide; cyclopentane; 1-ethoxy-3a-methyl-azulen-4-one; iron 499038 NSC649307 sensitive
hsa-miR-539-5p Cuspidatin c 5459164 NSC636859 sensitive
hsa-miR-539-5p Cytovaricin 5477715 NSC349622 sensitive
hsa-miR-539-5p Di-n-octyl-secalonsaure a 430141 NSC268925 sensitive
hsa-miR-539-5p Diethyl 4-hydroxy-2-(4-methoxyphenyl)-6-oxo-4-phenyl-1,3-cyclohexanedicarboxylate 386764 NSC679443 sensitive
hsa-miR-539-5p Diethylcyanine 5717105 NSC97374 sensitive
hsa-miR-539-5p Dimethyl (1s,7s,8s,9s,10s,12s)-9,10-diacetyloxy-11-[tert-butyl(dimethyl)silyl]oxy-7-phenylmethoxy-2-oxa-3-azatricyclo[6.3.1.04,12]dodec-3-ene-1,12-dicarboxylate 360859 NSC623520 sensitive
hsa-miR-539-5p Ethyl (E)-3-(6-methoxy-1-thiophen-3-yl-3,4-dihydronaphthalen-2-yl)prop-2-enoate 24205739 NSC736553 sensitive
hsa-miR-539-5p Euphorbia substance spr5 5459191 NSC640929 sensitive
hsa-miR-539-5p Heteromine a 391982 NSC691767 sensitive
hsa-miR-539-5p Indanthren corinth rk 5351878 NSC74702 sensitive
hsa-miR-539-5p Inosine, 6-thio-, 2',3',5'-tripentanoate 4208664 NSC77495 resistant
hsa-miR-539-5p Inostamycin 368135 NSC638478 sensitive
hsa-miR-539-5p Insariotoxin 6711181 NSC138780 sensitive
hsa-miR-539-5p Isobaccharin 5358646 NSC269760 sensitive
hsa-miR-539-5p Isobrucein a 322357 NSC279503 sensitive
hsa-miR-539-5p J3.522.543i 6163542 NSC113053 resistant
hsa-miR-539-5p Kinetin riboside 3832 NSC120958 resistant
hsa-miR-539-5p Laurusin 135476719 NSC106486 resistant
hsa-miR-539-5p Leucinostatine d 5459065 NSC608984 sensitive
hsa-miR-539-5p Maxima isoflavone d 343081 NSC382028 sensitive
hsa-miR-539-5p Methyl (1r,2s,3r,6r,13s,15r,17s)-10,15,16-trihydroxy-9,13-dimethyl-4,11-dioxo-3-[(z)-4,4,4-trifluoro-3-phenylbut-2-enoyl]oxy-5,18-dioxapentacyclo[12.5.0.01,6.02,17.08,13]nonadec-9-ene-17-carboxylate 5467619 NSC656901 sensitive
hsa-miR-539-5p Methyl 4-[3-(2-thienyl)quinoxalin-2-yl]oxybenzoate 388002 NSC682365 sensitive
hsa-miR-539-5p N-(6-methyl-1,3-benzothiazol-2-yl)-4-naphthalen-2-yl-2,4-dioxo-3-(3-oxo-1h-2-benzofuran-1-yl)butanamide 369455 NSC641225 sensitive
hsa-miR-539-5p N-benzyl-1-[10-[4-(benzylamino)-2-methylquinolin-1-ium-1-yl]decyl]-2-methylquinolin-1-ium-4-amine;perchlorate 387881 NSC682094 sensitive
hsa-miR-539-5p N,n-dimethyl-4-[(e)-2-(1-methyl-2,5-diphenylpyrazol-1-ium-3-yl)ethenyl]aniline;trifluoromethanesulfonate 5469868 NSC693576 sensitive
hsa-miR-539-5p Ncimech_000253 366144 NSC634471 sensitive
hsa-miR-539-5p NSC644919 NSC644919 sensitive
hsa-miR-539-5p NSC699071 NSC699071 sensitive
hsa-miR-539-5p NSC751830 NSC751830 resistant
hsa-miR-539-5p Oxidanium;1,3-diphenylpropane-1,3-dione;neodymium(3+);hydroxide 24202397 NSC647042 sensitive
hsa-miR-539-5p Phosphonium, triphenylpropenyl-, bromide, (e)- (8ci) 10714966 NSC289922 sensitive
hsa-miR-539-5p Propan-2-yl (3z)-4-benzyl-2,5-dioxo-6-[(2,4,5-trimethoxy-3-methylphenyl)methyl]-3-[(2,4,5-trimethoxy-3-methylphenyl)methylidene]piperazine-1-carboxylate 5387228 NSC622070 sensitive
hsa-miR-539-5p Propan-2-ylsulfanyl-(2,3,5,6-tetrachloropyridin-4-yl)sulfanylmethanethione 399833 NSC710969 resistant
hsa-miR-539-5p Propyl gallate 4947 NSC2626 resistant
hsa-miR-539-5p Pyrazolanthrone 8515 NSC75890 resistant
hsa-miR-539-5p Pyrimido[5,4-g]pteridine-2,4,6,8(1h,3h,7h,9h)-tetrone, 1,9-bis(methoxymethyl)-3,7-dimethyl-, 5-oxide 385097 NSC676032 sensitive
hsa-miR-539-5p Sarcoviolin 24202820 NSC726045 sensitive
hsa-miR-539-5p Sb-236687 17892742 NSC756422 resistant
hsa-miR-539-5p Sergeolide,desacetyl 125729 NSC364170 sensitive
hsa-miR-539-5p Stk366297 242249 NSC50648 sensitive
hsa-miR-539-5p Stl361983 256661 NSC83715 resistant
hsa-miR-539-5p Tetraoxo[?]dione 388215 NSC682809 sensitive
hsa-miR-539-5p Tris(1,10-phenanthroline)cerium(iii)-trithiocyanate 24202209 NSC632734 resistant
hsa-miR-539-5p Ursa-11,13(18)-dien-28-oic acid-3.beta.-ol 378695 NSC661747 sensitive
hsa-miR-539-5p Verapamil 2520 NSC272366 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-539-5p Doxorubicin 31703 NSC123127 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-539-5p Cisplatin 5460033 NSC119875 approved sensitive High Ovarian Cancer tissue
hsa-miR-539-5p Cisplatin 5460033 NSC119875 approved sensitive Low Non-Small Cell Lung Cancer cell line (A549, H1299)
hsa-miR-539-5p Vemurafenib 42611257 NSC761431 approved sensitive High Melanoma cell line (M14) (2uM)
hsa-miR-539-5p Trametinib 11707110 NSC758246 approved sensitive High Melanoma cell line (M14) (2uM)
hsa-miR-539-5p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-539-5p Osimertinib 71496458 NSC779217 approved sensitive cell line (HCC827)
hsa-miR-539-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-539-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-539-5p Testosterone+Tamoxifen sensitive cell line (MCF-7)
hsa-miR-539-5p Paclitaxel 36314 NSC125973 approved sensitive cell line (A2780)
hsa-miR-539-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (RPMI2650)
hsa-miR-539-5p Sunitinib 5329102 NSC750690 approved resistant tissue (CardA)
hsa-miR-539-5p Paclitaxel 36314 NSC125973 approved resistant cell line (SKOV3)
hsa-miR-539-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-539-5p Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)
hsa-miR-539-5p Paclitaxel/Docetaxel/Vinorelbine/Doxorubicin/Etoposide sensitive cell line (Bads-200)

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