miRTarBase - #MIRT053737


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pre-miRNA Information
pre-miRNA hsa-mir-1268a   
Genomic Coordinates chr15: 22225278 - 22225329
Description Homo sapiens miR-1268a stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-1268a
Sequence 5| CGGGCGUGGUGGUGGGGG |22
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs369807489 1 dbSNP
rs537950017 2 dbSNP
rs1442921203 4 dbSNP
rs1242314811 5 dbSNP
rs28599926 6 dbSNP
rs931410682 7 dbSNP
rs1360584039 10 dbSNP
rs1245652939 12 dbSNP
rs1321701831 14 dbSNP
rs1260292644 16 dbSNP
rs879525551 17 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol CAMK2G   
Synonyms CAMK, CAMK-II, CAMKG
Description calcium/calmodulin dependent protein kinase II gamma
Transcript NM_001222   
Other Transcripts NM_172169 , NM_172170 , NM_172171 , NM_172173   
Expression
Putative miRNA Targets on CAMK2G
3'UTR of CAMK2G
(miRNA target sites are highlighted)		 
>CAMK2G|NM_001222|3'UTR
   1 GCTCAGCCACAGGGGCTTTAGGAGATTCCAGCCGGAGGTCCAACCTTCGCAGCCAGTGGCTCTGGAGGGCCTGAGTGACA
  81 GCGGCAGTCCTGTTTGTTTGAGGTTTAAAACAATTCAATTACAAAAGCGGCAGCAGCCAATGCACGCCCCTGCATGCAGC
 161 CCTCCCGCCCGCCCTTCGTGTCTGTCTCTGCTGTACCGAGGTGTTTTTTACATTTAAGAAAAAAAAAAAAGAAAAAAAGA
 241 TTGTTTAAAAAAAAAAGGAATCCATACCATGATGCGTTTTAAAACCACCGACAGCCCTTGGGTTGGCAAGAAGGCAGGAG
 321 TATGTATGAGGTCCATCCTGGCATGAGCAGTGGCTCACCCACCGGCCTTGAAGAGGTGAGCTTGGCCTCTCTGGTCCCCA
 401 TGGACTTAGGGGGACCAGGCAAGAACTCTGACAGAGCTTTGGGGGCCGTGATGTGATTGCAGCTCCTGAGGTGGCCTGCT
 481 TACCCCAGGTCTAGGAATGAACTTCTTTGGAACTTGCATAGGCGCCTAGAATGGGGCTGATGAGAACATCGTGACCATCA
 561 GACCTACTTGGGAGAGAACGCAGAGCTCCCAGCCTGCTGTGGAGGCAGCTGAGAAGTGGTGGCCTCAGGACTGAGAGCCC
 641 GGACGTTGCTGTACTGTCTTGTTTAGTGTAGAAGGGAAGAGAATTGGTGCTGCAGAAGTGTACCCGCCATGAAGCCGATG
 721 AGAAACCTCGTGTTAGTCTGACATGCACTCACTCATCCATTTCTATAGGATGCACAATGCATGTGGGCCCTAATATTGAG
 801 GCCTTATCCCTGCAGCTAGGAGGGGGAGGGGTTGTTGCTGCTTTGCTTCGTGTTTTCTTCTAACCTGGCAAGGAGAGAGC
 881 CAGGCCCTGGTCAGGGCTCCCGTGCCGCCTTTGGCGGTTCTGTTTCTGTGCTGATCTGGACCATCTTTGTCTTGCCTTTT
 961 CACGGTAGTGGTCCCCATGCTGACCCTCATCTGGGCCTGGGCCCTCTGCCAAGTGCCCCTGTGGGATGGGAGGAGTGAGG
1041 CAGTGGGAGAAGAGGTGGTGGTCGTTTCTATGCATTCAGGCTGCCTTTGGGGCTGCCTCCCTTCTTATTCTTCCTTGCTG
1121 CACGTCCATCTCTTTTCCTGTCTTTGAGATTGACCTGACTGCTCTGGCAAGAAGAAGAGGTGTCCTTACAGAGGCCTCTT
1201 TACTGACCAACTGAAGTATAGACTTACTGCTGGACAATCTGCATGGGCATCACCCCTCCCCGCATGTAACCCAAAAGAGG
1281 TGTCCAGAGCCAAGGCTTCTACCTTCATTGTCCCTCTCTGTGCTCAAGGAGTTCCATTCCAGGAGGAAGAGATCTATACC
1361 CTAAGCAGATAGCAAAGAAGATAATGGAGGAGCAATTGGTCATGGCCTTGGTTTCCCTCAAAACAACGCTGCAGATTTAT
1441 CTGCACAAACATCTCCACTTTTGGGGGAAAGGTGGGTAGATTCCAGTTCCCTGGACTACCTTCAGGAGGCACGAGAGCTG
1521 GGAGAAGAGGCAAAGCTACAGGTTTACTTGGGAGCCAGCTGAGAAGAGAGCAGACTCACAGGTGCTGGTGCTTGGATTTA
1601 GCCAGGCTCCTCCGAGCACCTCATGCATGTCCCAGCCCCTGGGCCCTAGCCCTTTCCTGCCCTGCAGTCTGCAGTGCCAG
1681 CACGCAAATCCCTTCACCACAGGGTTTCGTTTTGCTGGCTTGAAGACAAATGGTCTTAGAATTCATTGAGACCCATAGCT
1761 TCATATGGCTGCTCCAGCCCCACTTCTTAGCATTCTTACTCCTCTTCTGGGGCTAATGTCAGCATCTATAGACAATAGAC
1841 TATTAAAAAATCACCTTTTAAACAAGAAACGGAAGGCATTTGATGCAGAATTTTTGCATGACAACATAGAAATAATTTAA
1921 AAATAGTGTTTGTTCTGAATGTTGGTAGACCCTTCATAGCTTTGTTACAATGAAACCTTGAACTGAAAATATTTAATAAA
2001 ATAACCTTTAAACAGTC
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' gggGGUGGUGGUGCGGGc 5'
             ||| :: ||||||| 
Target 5' cagCCAATG-CACGCCCc 3'
 134 - 150 146.00 -16.10
2 
miRNA  3' ggGGGUGGUGGUGCGGGc 5'
            |:::|:: ||||:|| 
Target 5' tcCTTGCTG-CACGTCCa 3'
 1112 - 1128 131.00 -17.20
3 
miRNA  3' ggGGGUGGUGGUGCGGGc 5'
            ||| ||  | ||||| 
Target 5' agCCCTCCCGCCCGCCCt 3'
 158 - 175 124.00 -27.90
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN31540983 12 COSMIC
COSN13285250 27 COSMIC
COSN5883510 36 COSMIC
COSN8189392 624 COSMIC
COSN26668035 659 COSMIC
COSN25800293 664 COSMIC
COSN26550532 669 COSMIC
COSN14817690 699 COSMIC
COSN16789946 715 COSMIC
COSN27852638 1047 COSMIC
COSN31540078 1142 COSMIC
COSN31595381 1216 COSMIC
COSN26636284 1255 COSMIC
COSN26636961 1285 COSMIC
COSN26647596 1299 COSMIC
COSN5290631 1443 COSMIC
COSN26357163 1620 COSMIC
COSN28684955 1649 COSMIC
COSN8640479 1649 COSMIC
COSN5883509 1706 COSMIC
COSN30375182 1721 COSMIC
COSN19038483 1759 COSMIC
COSN5290630 1882 COSMIC
COSN29810041 1986 COSMIC
COSN31571825 2127 COSMIC
COSN31571834 2236 COSMIC
COSN30165411 2241 COSMIC
COSN29696835 2254 COSMIC
COSN31588241 2341 COSMIC
COSN31547638 2344 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs769396006 4 dbSNP
rs371626952 16 dbSNP
rs777228582 17 dbSNP
rs1174912163 18 dbSNP
rs769299660 19 dbSNP
rs1426463422 22 dbSNP
rs747267407 23 dbSNP
rs369237403 27 dbSNP
rs779149832 28 dbSNP
rs757289835 29 dbSNP
rs1460717857 30 dbSNP
rs753946065 31 dbSNP
rs1316042661 33 dbSNP
rs561181148 35 dbSNP
rs773712378 36 dbSNP
rs993579554 39 dbSNP
rs542900703 43 dbSNP
rs751519320 47 dbSNP
rs1363387686 48 dbSNP
rs796849761 54 dbSNP
rs1056570916 58 dbSNP
rs1481892957 63 dbSNP
rs1475660360 79 dbSNP
rs938154455 81 dbSNP
rs1250252579 82 dbSNP
rs878959502 83 dbSNP
rs1417612896 87 dbSNP
rs1185587662 90 dbSNP
rs140988289 96 dbSNP
rs1424051041 100 dbSNP
rs1161726214 117 dbSNP
rs183921411 118 dbSNP
rs1490094578 123 dbSNP
rs1035132915 132 dbSNP
rs1298596999 148 dbSNP
rs1292107370 164 dbSNP
rs192099281 167 dbSNP
rs1224229006 175 dbSNP
rs1316670782 178 dbSNP
rs138874690 186 dbSNP
rs1244667572 189 dbSNP
rs1287092702 197 dbSNP
rs145031950 198 dbSNP
rs534904013 209 dbSNP
rs771347716 215 dbSNP
rs1251115528 219 dbSNP
rs1456666959 220 dbSNP
rs922314460 224 dbSNP
rs1244030407 226 dbSNP
rs893088912 230 dbSNP
rs1181899346 231 dbSNP
rs531219861 248 dbSNP
rs187167402 256 dbSNP
rs1170979746 261 dbSNP
rs543968170 269 dbSNP
rs148120926 271 dbSNP
rs963884755 271 dbSNP
rs182140638 272 dbSNP
rs767540066 274 dbSNP
rs1451456381 277 dbSNP
rs77733275 291 dbSNP
rs1304040489 301 dbSNP
rs1215667944 304 dbSNP
rs1406987815 308 dbSNP
rs1295439691 313 dbSNP
rs1316467835 322 dbSNP
rs116687307 324 dbSNP
rs751028927 325 dbSNP
rs545784161 333 dbSNP
rs1461087357 334 dbSNP
rs1208217316 339 dbSNP
rs145609513 340 dbSNP
rs918210939 346 dbSNP
rs1187063286 359 dbSNP
rs960699905 361 dbSNP
rs1476781705 362 dbSNP
rs1178405545 377 dbSNP
rs551469884 390 dbSNP
rs377399733 408 dbSNP
rs1339402951 410 dbSNP
rs763720991 414 dbSNP
rs141218742 415 dbSNP
rs1430757870 417 dbSNP
rs1287752894 425 dbSNP
rs1002727554 426 dbSNP
rs146560438 434 dbSNP
rs547874938 435 dbSNP
rs1011147487 438 dbSNP
rs1481831386 439 dbSNP
rs1231543259 440 dbSNP
rs142784922 446 dbSNP
rs775131768 450 dbSNP
rs1317723361 454 dbSNP
rs1275779183 470 dbSNP
rs149015833 474 dbSNP
rs1217962671 475 dbSNP
rs1323004554 481 dbSNP
rs549340284 483 dbSNP
rs933632598 489 dbSNP
rs1201425319 498 dbSNP
rs1269333210 501 dbSNP
rs1170468012 510 dbSNP
rs959500130 510 dbSNP
rs922286538 513 dbSNP
rs1409769487 514 dbSNP
rs1400930366 519 dbSNP
rs765549290 524 dbSNP
rs942470275 525 dbSNP
rs909716252 530 dbSNP
rs984395211 531 dbSNP
rs1304239970 540 dbSNP
rs1297429187 544 dbSNP
rs1442714689 545 dbSNP
rs1356043200 546 dbSNP
rs1434825845 549 dbSNP
rs560132862 552 dbSNP
rs1332182837 565 dbSNP
rs1469225561 566 dbSNP
rs1283990614 576 dbSNP
rs1361591211 579 dbSNP
rs982153549 580 dbSNP
rs1292342401 595 dbSNP
rs1196566461 598 dbSNP
rs966829828 598 dbSNP
rs190443057 615 dbSNP
rs918469304 617 dbSNP
rs992763227 625 dbSNP
rs1377982495 626 dbSNP
rs1425954091 630 dbSNP
rs1163642293 631 dbSNP
rs1032898725 635 dbSNP
rs1234955711 638 dbSNP
rs1404090621 640 dbSNP
rs1331361614 641 dbSNP
rs1336662612 642 dbSNP
rs960683322 643 dbSNP
rs1035041946 647 dbSNP
rs542306422 651 dbSNP
rs1246864570 659 dbSNP
rs1263854756 660 dbSNP
rs969909129 663 dbSNP
rs1225390740 664 dbSNP
rs1315173857 665 dbSNP
rs1438145058 666 dbSNP
rs1306624239 667 dbSNP
rs112016716 668 dbSNP
rs1375346452 671 dbSNP
rs1183741758 672 dbSNP
rs1282147585 677 dbSNP
rs1367362908 681 dbSNP
rs868576596 682 dbSNP
rs1472101678 685 dbSNP
rs1451841812 687 dbSNP
rs1170078189 690 dbSNP
rs1057410 694 dbSNP
rs1465385109 695 dbSNP
rs1329698443 699 dbSNP
rs1408624133 706 dbSNP
rs1453641622 707 dbSNP
rs1338588299 708 dbSNP
rs1455232915 710 dbSNP
rs1344076832 711 dbSNP
rs1159466607 712 dbSNP
rs927593029 715 dbSNP
rs79768185 716 dbSNP
rs532906993 717 dbSNP
rs997882439 721 dbSNP
rs1195982019 728 dbSNP
rs1203843428 728 dbSNP
rs1254872153 728 dbSNP
rs1255915857 728 dbSNP
rs896941328 728 dbSNP
rs980402206 728 dbSNP
rs11000784 729 dbSNP
rs1477762045 731 dbSNP
rs1169068419 736 dbSNP
rs1302442907 736 dbSNP
rs1444591287 736 dbSNP
rs1470428851 736 dbSNP
rs1400184587 737 dbSNP
rs559033745 739 dbSNP
rs75231733 740 dbSNP
rs75300783 741 dbSNP
rs1011450617 744 dbSNP
rs1037086009 746 dbSNP
rs941063746 747 dbSNP
rs1206103535 750 dbSNP
rs1325332353 753 dbSNP
rs1223778212 754 dbSNP
rs888124528 754 dbSNP
rs201574041 755 dbSNP
rs892651306 758 dbSNP
rs1484968988 764 dbSNP
rs757911782 772 dbSNP
rs1055362443 785 dbSNP
rs540680198 786 dbSNP
rs1192048183 787 dbSNP
rs1271536880 791 dbSNP
rs938246608 797 dbSNP
rs1318900311 798 dbSNP
rs1376177057 815 dbSNP
rs1052610260 830 dbSNP
rs998423191 839 dbSNP
rs1159281335 842 dbSNP
rs1455538169 842 dbSNP
rs900831145 843 dbSNP
rs1039818685 849 dbSNP
rs1296220562 855 dbSNP
rs1244924303 856 dbSNP
rs942457676 858 dbSNP
rs111720283 860 dbSNP
rs945452375 861 dbSNP
rs1048147831 871 dbSNP
rs1300295939 873 dbSNP
rs771308458 875 dbSNP
rs914014718 876 dbSNP
rs989876174 877 dbSNP
rs929772426 878 dbSNP
rs1260808955 886 dbSNP
rs918450945 890 dbSNP
rs992724222 892 dbSNP
rs1352284549 893 dbSNP
rs959985189 897 dbSNP
rs1017559927 898 dbSNP
rs1490648681 933 dbSNP
rs1191052011 939 dbSNP
rs149831005 942 dbSNP
rs181095096 944 dbSNP
rs188226340 945 dbSNP
rs1182714723 947 dbSNP
rs1379794551 958 dbSNP
rs1417884177 960 dbSNP
rs1288878902 969 dbSNP
rs1455041567 979 dbSNP
rs969416587 985 dbSNP
rs1165519031 989 dbSNP
rs1022777182 991 dbSNP
rs1347709805 993 dbSNP
rs2306327 995 dbSNP
rs772204536 999 dbSNP
rs1031154188 1001 dbSNP
rs1015313876 1002 dbSNP
rs1186039531 1004 dbSNP
rs1309469231 1016 dbSNP
rs539462231 1018 dbSNP
rs373212568 1020 dbSNP
rs901468948 1021 dbSNP
rs1322916997 1022 dbSNP
rs1187134909 1025 dbSNP
rs1221403936 1036 dbSNP
rs888081804 1039 dbSNP
rs1486990663 1044 dbSNP
rs1237851726 1048 dbSNP
rs1018537213 1055 dbSNP
rs1438028206 1058 dbSNP
rs748250811 1060 dbSNP
rs1385926125 1062 dbSNP
rs1054804034 1063 dbSNP
rs1366523701 1065 dbSNP
rs566036395 1072 dbSNP
rs377082098 1074 dbSNP
rs779308378 1076 dbSNP
rs888139022 1077 dbSNP
rs1399184588 1079 dbSNP
rs1444112853 1087 dbSNP
rs57064693 1088 dbSNP
rs1379180646 1089 dbSNP
rs929734699 1091 dbSNP
rs1228280774 1098 dbSNP
rs112106325 1101 dbSNP
rs1309752828 1120 dbSNP
rs914072584 1120 dbSNP
rs1219671584 1131 dbSNP
rs747730957 1132 dbSNP
rs989539453 1135 dbSNP
rs745627892 1137 dbSNP
rs1306795982 1138 dbSNP
rs1057022458 1139 dbSNP
rs1295707296 1141 dbSNP
rs567504911 1142 dbSNP
rs1430237953 1148 dbSNP
rs1343077186 1151 dbSNP
rs1171203317 1153 dbSNP
rs927161025 1158 dbSNP
rs980059818 1164 dbSNP
rs548886103 1165 dbSNP
rs1178092312 1168 dbSNP
rs1359257087 1170 dbSNP
rs1446709683 1174 dbSNP
rs915276456 1188 dbSNP
rs986133824 1190 dbSNP
rs1364782779 1198 dbSNP
rs917626719 1199 dbSNP
rs1401129126 1201 dbSNP
rs953945932 1202 dbSNP
rs989506530 1203 dbSNP
rs1405176385 1210 dbSNP
rs956827841 1212 dbSNP
rs1279667889 1214 dbSNP
rs577312433 1215 dbSNP
rs1031123154 1222 dbSNP
rs1208191721 1226 dbSNP
rs976855217 1227 dbSNP
rs965521371 1231 dbSNP
rs530706223 1237 dbSNP
rs1165801606 1245 dbSNP
rs1460939948 1246 dbSNP
rs977086491 1247 dbSNP
rs1372968726 1249 dbSNP
rs1476688464 1253 dbSNP
rs559251883 1254 dbSNP
rs1018919986 1262 dbSNP
rs1413547977 1265 dbSNP
rs961214182 1277 dbSNP
rs1007156540 1278 dbSNP
rs1015847485 1281 dbSNP
rs1298074885 1284 dbSNP
rs1005267405 1286 dbSNP
rs1407188304 1289 dbSNP
rs888090454 1291 dbSNP
rs952475249 1297 dbSNP
rs1367244347 1305 dbSNP
rs1430436327 1307 dbSNP
rs1033344789 1319 dbSNP
rs1026690499 1323 dbSNP
rs1354457269 1328 dbSNP
rs906773794 1335 dbSNP
rs1285279189 1345 dbSNP
rs1046657572 1346 dbSNP
rs1010234492 1347 dbSNP
rs1200815135 1347 dbSNP
rs1477499463 1351 dbSNP
rs993909345 1354 dbSNP
rs1189026220 1359 dbSNP
rs1447156796 1361 dbSNP
rs1381656450 1371 dbSNP
rs896874414 1379 dbSNP
rs1054396004 1381 dbSNP
rs1193815992 1389 dbSNP
rs1015474153 1397 dbSNP
rs910658370 1398 dbSNP
rs1056901616 1403 dbSNP
rs569868028 1404 dbSNP
rs551612571 1412 dbSNP
rs147169242 1413 dbSNP
rs1044690362 1433 dbSNP
rs947350123 1438 dbSNP
rs757129997 1439 dbSNP
rs1239565249 1449 dbSNP
rs1307168326 1453 dbSNP
rs1351489793 1457 dbSNP
rs976657804 1460 dbSNP
rs961598047 1461 dbSNP
rs1346952602 1462 dbSNP
rs989475499 1477 dbSNP
rs576807650 1479 dbSNP
rs540766592 1494 dbSNP
rs528939893 1496 dbSNP
rs2384389 1501 dbSNP
rs923988016 1511 dbSNP
rs751531248 1513 dbSNP
rs1177531248 1514 dbSNP
rs145084581 1519 dbSNP
rs908364576 1525 dbSNP
rs984401491 1528 dbSNP
rs1413556768 1534 dbSNP
rs1390068978 1537 dbSNP
rs1331252567 1541 dbSNP
rs1401380463 1549 dbSNP
rs1396207255 1551 dbSNP
rs1446303832 1552 dbSNP
rs777083103 1557 dbSNP
rs757961566 1558 dbSNP
rs1384996845 1560 dbSNP
rs752302260 1560 dbSNP
rs543676032 1561 dbSNP
rs1355517687 1567 dbSNP
rs866407742 1581 dbSNP
rs1175737096 1594 dbSNP
rs1259739998 1596 dbSNP
rs1318175041 1604 dbSNP
rs1401988758 1604 dbSNP
rs986113260 1605 dbSNP
rs780581154 1612 dbSNP
rs764842613 1617 dbSNP
rs759222939 1620 dbSNP
rs993791716 1621 dbSNP
rs1173344533 1628 dbSNP
rs1424709101 1629 dbSNP
rs1465302422 1636 dbSNP
rs139557358 1637 dbSNP
rs1404469873 1639 dbSNP
rs532342001 1641 dbSNP
rs1396725741 1642 dbSNP
rs1333588462 1643 dbSNP
rs1250971395 1652 dbSNP
rs1197492412 1656 dbSNP
rs1459883477 1659 dbSNP
rs1339865673 1660 dbSNP
rs1261990379 1674 dbSNP
rs1203703916 1676 dbSNP
rs1035408842 1685 dbSNP
rs558175302 1686 dbSNP
rs1217665605 1689 dbSNP
rs1255818677 1692 dbSNP
rs761026977 1694 dbSNP
rs892748434 1707 dbSNP
rs905676024 1712 dbSNP
rs1277278137 1713 dbSNP
rs1441203740 1716 dbSNP
rs1335549993 1719 dbSNP
rs1044278019 1734 dbSNP
rs773773016 1740 dbSNP
rs1477671837 1741 dbSNP
rs1191927373 1742 dbSNP
rs1001016455 1744 dbSNP
rs1466733673 1749 dbSNP
rs536156380 1756 dbSNP
rs1404486527 1758 dbSNP
rs534264464 1759 dbSNP
rs889295779 1769 dbSNP
rs150730006 1771 dbSNP
rs1399213916 1774 dbSNP
rs1404421915 1777 dbSNP
rs935310819 1780 dbSNP
rs746340548 1800 dbSNP
rs933410782 1824 dbSNP
rs923241041 1836 dbSNP
rs1036806819 1840 dbSNP
rs1364181033 1846 dbSNP
rs1287424833 1851 dbSNP
rs939951831 1854 dbSNP
rs1044612 1862 dbSNP
rs1442737780 1867 dbSNP
rs554195276 1871 dbSNP
rs3812636 1873 dbSNP
rs944174861 1874 dbSNP
rs1376021406 1882 dbSNP
rs1462317132 1883 dbSNP
rs1441681214 1893 dbSNP
rs911371425 1899 dbSNP
rs774614042 1903 dbSNP
rs1361159258 1904 dbSNP
rs1419002161 1914 dbSNP
rs980480340 1923 dbSNP
rs568594104 1924 dbSNP
rs970497199 1925 dbSNP
rs184291371 1940 dbSNP
rs1368307568 1941 dbSNP
rs182146141 1955 dbSNP
rs1350879696 1959 dbSNP
rs536863347 1960 dbSNP
rs569786070 1964 dbSNP
rs1267640551 1970 dbSNP
rs1381006039 1979 dbSNP
rs551435243 1980 dbSNP
rs1265590953 1981 dbSNP
rs1459259126 1984 dbSNP
rs1001090306 2009 dbSNP
rs889243357 2010 dbSNP
rs1439009449 2012 dbSNP
rs1003035136 2033 dbSNP
rs969869237 2034 dbSNP
rs1029125114 2035 dbSNP
rs533046970 2036 dbSNP
rs901964246 2042 dbSNP
rs1036347945 2045 dbSNP
rs1448459976 2065 dbSNP
rs778320135 2067 dbSNP
rs1023146975 2068 dbSNP
rs983771418 2069 dbSNP
rs748910806 2074 dbSNP
rs1322821315 2084 dbSNP
rs1011371727 2087 dbSNP
rs1271639935 2093 dbSNP
rs931223711 2093 dbSNP
rs1160649841 2097 dbSNP
rs565370376 2106 dbSNP
rs926432613 2107 dbSNP
rs757190595 2110 dbSNP
rs1258227965 2111 dbSNP
rs1052939696 2114 dbSNP
rs546966283 2116 dbSNP
rs144103829 2117 dbSNP
rs902504556 2122 dbSNP
rs1041057651 2128 dbSNP
rs1170888530 2129 dbSNP
rs1399072283 2131 dbSNP
rs561641226 2133 dbSNP
rs11539660 2138 dbSNP
rs549805619 2141 dbSNP
rs1239883178 2144 dbSNP
rs956550281 2156 dbSNP
rs911270792 2165 dbSNP
rs1447043013 2169 dbSNP
rs1291824653 2171 dbSNP
rs367953875 2173 dbSNP
rs749580971 2174 dbSNP
rs1357825372 2176 dbSNP
rs953664847 2180 dbSNP
rs1029115304 2181 dbSNP
rs1256651098 2194 dbSNP
rs142568315 2195 dbSNP
rs997664589 2198 dbSNP
rs1181170769 2205 dbSNP
rs1255166623 2206 dbSNP
rs920118678 2212 dbSNP
rs1247367628 2216 dbSNP
rs1194081876 2217 dbSNP
rs1422563654 2224 dbSNP
rs546215432 2225 dbSNP
rs1015396001 2226 dbSNP
rs940295620 2228 dbSNP
rs1466004281 2229 dbSNP
rs928278800 2231 dbSNP
rs1362979893 2235 dbSNP
rs1049123763 2242 dbSNP
rs1430154513 2242 dbSNP
rs1327080243 2243 dbSNP
rs190831933 2246 dbSNP
rs981099724 2252 dbSNP
rs931213613 2253 dbSNP
rs970133070 2260 dbSNP
rs1311630733 2261 dbSNP
rs905132947 2263 dbSNP
rs1278157961 2270 dbSNP
rs1489229854 2283 dbSNP
rs1022689459 2314 dbSNP
rs990319221 2319 dbSNP
rs770767337 2320 dbSNP
rs957189573 2322 dbSNP
rs1403261876 2323 dbSNP
rs1241250862 2325 dbSNP
rs1474222877 2329 dbSNP
rs1192526699 2333 dbSNP
rs1031490407 2347 dbSNP
rs11539661 2352 dbSNP
rs1432140704 2356 dbSNP
rs1171164261 2361 dbSNP
rs1163928803 2364 dbSNP
rs1420826129 2366 dbSNP
rs949212312 2366 dbSNP
rs746883499 2367 dbSNP
rs1343763359 2368 dbSNP
rs1438905801 2374 dbSNP
rs185485946 2374 dbSNP
rs901733683 2376 dbSNP
rs1167235148 2382 dbSNP
rs1475487532 2398 dbSNP
rs917775840 2399 dbSNP
rs1019281593 2406 dbSNP
rs1425139596 2406 dbSNP
rs1052575464 2409 dbSNP
rs1008205723 2416 dbSNP
rs1311543180 2423 dbSNP
rs1196845544 2424 dbSNP
rs935103574 2429 dbSNP
rs1490068537 2432 dbSNP
rs889794788 2457 dbSNP
rs1801078 2468 dbSNP
rs1223465973 2476 dbSNP
rs1467748853 2488 dbSNP
rs1268660455 2497 dbSNP
rs1191269536 2501 dbSNP
rs1223637941 2503 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions USSC
Location of target site 3'UTR
Original Description (Extracted from the article) ... Table 2. Putative target genes and related pathways for miRNAs. ...

- Bakhshandeh B; Soleimani M; Paylakhi SH; Ghaemi N, 2012, Journal of genetics.

Article - Bakhshandeh B; Soleimani M; Paylakhi SH; Ghaemi N
- Journal of genetics, 2012
Generating appropriate cartilage for clinical applications to heal skeletal tissue loss is a major health concern. In this regard, cell-based approaches offer a potential therapeutic strategy for cartilage repair, although little is known about the precise mechanism of chondrogenesis. Unrestricted somatic stem cell (USSC) is considered as a suitable candidate because of its potential for differentiating into multiple cell types. Recent studies show that microRNAs (miRNAs) are involved in several biological processes including development and differentiation. To identify the chondro-specific miRNA signature, miRNA patterns of USSCs and differentiated chondrocytes were investigated using microarrays and validation by qPCR. Prior to these analyses, chondrogenic commitment of differentiated USSCs was verified by immunocytochemistry, specific staining and evaluation of some main chondrogenic marker genes. Various in silico explorations (for both putative targets and signalling pathways) and empirical analyses (miRNA transfections followed by qPCR of some chondrogenic indicators) were carried out to support our results. Transient modulation of multiple chondro-miRs (such as mir-630, mir-624 and mir-376) with chondrocyte targets (such as TGFbR, MAP3K, collagens, SMADs and cadherins) as mediators of chondrogenic signalling pathways including cell-cell interactions, TGF-beta, and MAPK signalling suggests a mechanism for genetic induction of chondrogenic differentiation. In conclusion, this research reveals more details about the allocation of USSCs into the chondrocytes through identification of miRNA signature which modulates targets and pathways required for chondrogenic lineage and could provide guidelines for future clinical treatments and anti-miRNA therapies.
LinkOut: [PMID: 22942087]
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
44 hsa-miR-1268a Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT035845 POLR2I RNA polymerase II subunit I 1 1
MIRT035847 FASN fatty acid synthase 1 1
MIRT053736 SOX12 SRY-box 12 1 1
MIRT053737 CAMK2G calcium/calmodulin dependent protein kinase II gamma 1 1
MIRT473717 MAPK1 mitogen-activated protein kinase 1 2 2
MIRT483654 QSOX2 quiescin sulfhydryl oxidase 2 2 4
MIRT484277 AIP aryl hydrocarbon receptor interacting protein 2 4
MIRT486674 WDR81 WD repeat domain 81 2 2
MIRT488672 WWP2 WW domain containing E3 ubiquitin protein ligase 2 2 4
MIRT493453 ITFG3 family with sequence similarity 234 member A 2 2
MIRT495902 ZNF641 zinc finger protein 641 2 2
MIRT500188 BARX1 BARX homeobox 1 2 4
MIRT512015 DNAJC10 DnaJ heat shock protein family (Hsp40) member C10 2 2
MIRT521134 SGPL1 sphingosine-1-phosphate lyase 1 2 4
MIRT530047 TRIM72 tripartite motif containing 72 2 2
MIRT531519 NOM1 nucleolar protein with MIF4G domain 1 2 2
MIRT543736 DHCR7 7-dehydrocholesterol reductase 2 2
MIRT558054 EVI5L ecotropic viral integration site 5 like 2 2
MIRT569603 TRIM29 tripartite motif containing 29 2 2
MIRT570027 FAM228A family with sequence similarity 228 member A 2 2
MIRT573595 CERS1 ceramide synthase 1 2 2
MIRT623884 FRMPD4 FERM and PDZ domain containing 4 2 2
MIRT630000 PDE6B phosphodiesterase 6B 2 2
MIRT632716 MSANTD4 Myb/SANT DNA binding domain containing 4 with coiled-coils 2 2
MIRT633497 ERO1L endoplasmic reticulum oxidoreductase 1 alpha 1 1
MIRT637076 SELPLG selectin P ligand 2 2
MIRT638183 TLN1 talin 1 2 2
MIRT638767 EPB41 erythrocyte membrane protein band 4.1 2 2
MIRT668073 GMPS guanine monophosphate synthase 2 2
MIRT669874 RAET1E retinoic acid early transcript 1E 2 2
MIRT670664 KIAA1551 KIAA1551 2 2
MIRT671283 RPL37A ribosomal protein L37a 2 2
MIRT675055 OR7D2 olfactory receptor family 7 subfamily D member 2 2 2
MIRT682784 BLOC1S3 biogenesis of lysosomal organelles complex 1 subunit 3 2 2
MIRT683344 SCARF1 scavenger receptor class F member 1 2 2
MIRT690283 ZNF154 zinc finger protein 154 2 2
MIRT695172 SLC25A33 solute carrier family 25 member 33 2 2
MIRT695222 SCAMP3 secretory carrier membrane protein 3 2 2
MIRT700485 PTPRF protein tyrosine phosphatase, receptor type F 2 2
MIRT700601 PRKCA protein kinase C alpha 2 2
MIRT701410 NKRF NFKB repressing factor 2 2
MIRT703995 EIF5A2 eukaryotic translation initiation factor 5A2 2 2
MIRT711232 RETSAT retinol saturase 2 2
MIRT719510 TMEM175 transmembrane protein 175 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-1268a Trastuzumab approved NULL Microarray SKBR3 cells. 22384020 2012 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-1268a Oxaliplatin 6857599 NSC266046 approved sensitive High Colorectal Cancer cell line (HCT-116)
hsa-miR-1268a Paclitaxel 36314 NSC125973 approved resistant High Laryngeal Cancer cell line (Hep2)
hsa-miR-1268a Gemcitabine 60750 NSC613327 approved resistant High Pancreatic Cancer cell line (PANC-1)
hsa-miR-1268a Fluorouracil 3385 NSC19893 approved resistant High Pancreatic Cancer cell line (PANC-1)
hsa-miR-1268a Imatinib 5291 NSC743414 approved sensitive High Gastrointestinal Stromal Tumor tissue
hsa-miR-1268a Fluorouracil 3385 NSC19893 approved resistant High Esophageal Adenocarcinoma cell line (OE19)
hsa-miR-1268a Cisplatin 5460033 NSC119875 approved sensitive High Non-Small Cell Lung Cancer cell line (A549)
hsa-miR-1268a Platinum 23939 sensitive High Ovarian Cancer tissue
hsa-miR-1268a Fluorouracil 3385 NSC19893 approved sensitive High Pancreatic Cancer cell line (PATU8988)
hsa-miR-1268a Docetaxel 148124 NSC628503 approved resistant High Breast Cancer cell line (MDA-MB-231)
hsa-miR-1268a Vinorelbine 44424639 approved resistant High Breast Cancer cell line (MDA-MB-231)
hsa-miR-1268a Paclitaxel 36314 NSC125973 approved resistant High Non-Small Cell Lung Cancer cell line (A549)
hsa-miR-1268a Temozolomide 5394 NSC362856 approved sensitive Low Glioblastoma cell line (U87, LN229)
hsa-miR-1268a Trametinib 11707110 NSC758246 approved resistant High Melanoma cell line (M14) (2uM)
hsa-miR-1268a Vemurafenib 42611257 NSC761431 approved resistant High Melanoma cell line (M14) (2uM)
hsa-miR-1268a Cisplatin 5460033 NSC119875 approved resistant Low Tongue Squamous Cell Carcinoma cell line (CAL-27, SCC-9)
hsa-miR-1268a Paclitaxel 36314 NSC125973 approved resistant High Endometrial Serous Carcinoma cell line (USPC1)
hsa-miR-1268a Paclitaxel 36314 NSC125973 approved sensitive High Breast Cancer cell line (BCap37)
hsa-miR-1268a Doxorubicin 31703 NSC123127 approved sensitive High Colorectal Cancer cell line (HCT8)
hsa-miR-1268a Etoposide 36462 NSC141540 approved sensitive High Colorectal Cancer cell line (HCT8)
hsa-miR-1268a Vinorelbine 44424639 approved sensitive High Colorectal Cancer cell line (HCT8)
hsa-miR-1268a Vincristine 5978 approved sensitive High Colorectal Cancer cell line (HCT8)
hsa-miR-1268a Paclitaxel 36314 NSC125973 approved sensitive High Colorectal Cancer cell line (HCT8)
hsa-mir-1268a Dabrafenib 44462760 NSC764134 approved resistant cell line (A375)
hsa-mir-1268a Androstenedione+Letrozole sensitive cell line (MCF-7)
hsa-mir-1268a Cisplatin 5460033 NSC119875 approved resistant cell line (OE19)
hsa-mir-1268a Fluorouracil 3385 NSC19893 approved resistant cell line (OE19)
hsa-mir-1268a Cisplatin 5460033 NSC119875 approved resistant cell line (BxPC3)
hsa-miR-1268a Gefitinib 123631 NSC715055 approved sensitive cell line (HCC827)
hsa-miR-1268a Cisplatin 5460033 NSC119875 approved sensitive cell line (CAL-27) (mitochondrial RNA)
hsa-miR-1268a Paclitaxel 36314 NSC125973 approved resistant cell line (BAS)
hsa-miR-1268a Tamoxifen+Fulvestrant sensitive cell line (LCC9)
hsa-miR-1268a Osimertinib 71496458 NSC779217 approved sensitive cell line (H1975)
hsa-miR-1268a Cisplatin 5460033 NSC119875 approved sensitive cell line (MGC-803)
hsa-miR-1268a Pegylated interferon alpha+Ribavirin resistant tissue (chronic hepatitis C)
hsa-miR-1268a Cisplatin 5460033 NSC119875 approved resistant cell line (A549)
hsa-miR-1268a Neoadjuvant chemotherapy sensitive tissue (breast cancer)
hsa-miR-1268a Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-1268a Paclitaxel/Docetaxel/Vinorelbine/Doxorubicin/Etoposide/Methotrexate/Gemcitabine sensitive cell line (Bats-72)
hsa-miR-1268a Cisplatin 5460033 NSC119875 approved resistant cell line (MDAH-2774)

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