pre-miRNA Information
pre-miRNA hsa-mir-210   
Genomic Coordinates chr11: 568089 - 568198
Synonyms MIRN210, mir-210, MIR210
Description Homo sapiens miR-210 stem-loop
Comment This human miRNA was predicted by computational methods using conservation with mouse and Fugu rubripes sequences .
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-210-3p
Sequence 66| CUGUGCGUGUGACAGCGGCUGA |87
Evidence Experimental
Experiments Cloned
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 12 11 - 568122 25582055 MiREDiBase
A-to-I 14 11 - 568120 26028588 MiREDiBase
C-to-U 1 11 - 568133 26209130 MiREDiBase
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs753825152 1 dbSNP
rs759616365 3 dbSNP
rs1247955373 6 dbSNP
rs558661304 9 dbSNP
rs1490451308 13 dbSNP
rs1344162213 14 dbSNP
rs745930382 15 dbSNP
rs1220183952 16 dbSNP
rs1355496181 17 dbSNP
rs1280245998 19 dbSNP
rs781628850 20 dbSNP
rs1241231800 22 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Biomarker Information
Biomarker ID Name Type Discovered From Mode Level Source Testing Methods
BX0CY6 miR-210 Predictive Biomarker (PRD); Safety Biomarker (SAF) Clinical/Experimental Data Expression Increase Urine Quantitative real-time reverse transcription PCR
BX0CY6 miR-210 Predictive Biomarker (PRD); Safety Biomarker (SAF) Clinical/Experimental Data Expression Low Blood Reverse transcription-polymerase chain reaction
Gene Information
Gene Symbol NDUFA4   
Synonyms CI-9k, CI-MLRQ, MLRQ
Description NDUFA4, mitochondrial complex associated
Transcript NM_002489   
Expression
Putative miRNA Targets on NDUFA4
3'UTR of NDUFA4
(miRNA target sites are highlighted)
>NDUFA4|NM_002489|3'UTR
   1 ATGAAATGTTTCACTATAACGCTGCTTTAGAATGAAGGTCTTCCAGAAGCCACATCCGCACAATTTTCCACTTAACCAGG
  81 AAATATTTCTCCTCTAAATGCATGAAATCATGTTGGAGATCTCTATTGTAATCTCTATTGGAGATTACAATGATTAAATC
 161 AATAAATAACTGAAACTTGATATGTGTCACTTTTTTATGCTGAAAGTATGCTCTGAACTTTAGAGTATAGGAAATTAACT
 241 ATTAGAATTTAAAGAATTTCTTGAATTTCTGTAGTTTGAAAATACGACTTTAAGCTGCTTTAGTAAAACACTTCCATTTT
 321 GTGTATAGACTGTTGGTAACTTCACTAGAGCATACATAACAACTGGAACTGGAAATTATACAAAAGTAAATTGGGAAGGA
 401 TACTCCAGCATCTGACACTGGCAAAATGGAAACCTTTGAGTTTCTCTTACTGGCTGTTGAAGTGTGTGCAGTTTTTAACA
 481 ATGGTTTTTACTTGGCATCTCTTTGTTGTGATTTTCAAGGTTATAAGTTGCTTTGGTCCTAGGATTGAAGTTGAAATCTG
 561 AGTTTATCAGTGCTAACCATGGTGCTAGTAGTCAAGAGATCTTGAGAATTTTGGCTGCTGAGTCTTGGTGCAGGGTGCAG
 641 GTTTTCTTTTCTTTTTTCTTTTTTTTTTTTTTGAGATAGTCTCTGTCACCCAGGCTGGAGTGCAGTGGTACAAACATGGA
 721 TCACTGCAGCCTCTACCTCCCGGGCTTAAGTGATCCTCCTGCCTCAGCCCCTAAGTAGCCGGGACTACAGGTATGTGCCA
 801 CCATGCCCAGTTAATTTTTGTAATTTTTTTTAGAGACAGGGTTTTGCCATGTTGCCCAGGCTGGTCTCAAACTCTTGAGC
 881 TCAAGCGATCCATTCTCCTCAGCCTCCCAGGGTGCTGGGATTACAGGCGTGAGCCATTGCGCTTAGCCATGGTGCAGGTT
 961 TTCAAAGGCCAGGAAGTATATTCATAATTTTAAGATGGGGAATATAGCAAGTTTTCACATAGGTGTGTGTAAGTCATCAC
1041 ATCATAGAAACTTGAGGAATTCAGTGACATTAATTTTGGATTTTCATACGTAAGTATACAATTAAATGTTTACAGGGTAG
1121 TAGAAGCACATTTTAAATGTCAGGAACTGAACTAAGTATTTGAATTACGTGGATTATCTCAAAAATTTTGAAATTGTTAA
1201 ACGAGTTGAATTACTTGAATTCATTCTGTTAGTCAAATGGTGGATATTTACACCCATGTAGTTTTGAATTTAGAGTGTGT
1281 AGAGTGTTTTCAGTTACCAGACTCCATGCTTTTACCTCCTATGTGTCAGGTATAATTTGAACCTCTAAGAACAGGGTTTC
1361 TCAACCTTGCCACTGTTGACTATTTCTGAAAGACAGTTTGGTTTAGCAGACCATCCCATGCGCTTTAGCTTGTTTAGTAG
1441 CTAACTTGGGCTCTGCCACTACAGACAAAAAGCACTCTTTCCCTCCAATTCCCACAGGCTATGAGAAGAATGGAGACATT
1521 ACCAAATGTCCATTGGTGGGCAAAATTGCTTCATTCCTACCTCTGTTGAGAATTACTCTAGATCCTTTGGCACAAATTAC
1601 CTCAAAGTTTAAAATTGTGTAAACAAACAGTGTGTCATGTAATTGAAAAACATTAAGCAACTCCAAATAAATGCTACATT
1681 AAG
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1
miRNA  3' agUCGGCGACAGUGUGCGUGUc 5'
            |||| |  ||   |||||| 
Target 5' gaAGCCAC-ATC---CGCACAa 3'
46 - 63 123.00 -12.80
2
miRNA  3' agucggCGACAGUGUGCGUGUc 5'
                |: || | | ||||| 
Target 5' tacaggGTAGT-AGAAGCACAt 3'
1111 - 1131 115.00 -7.80
3
miRNA  3' agUCGGC-GACAGUGUGCGUGuc 5'
            ||| | |  || ||:||:|  
Target 5' ttAGCAGACCATCCCATGCGCtt 3'
1403 - 1425 108.00 -12.90
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30499979 20 COSMIC
COSN509652 57 COSMIC
COSN31578087 89 COSMIC
COSN31500396 101 COSMIC
COSN31531304 105 COSMIC
COSN31605875 118 COSMIC
COSN31510680 137 COSMIC
COSN31550534 151 COSMIC
COSN31549951 242 COSMIC
COSN20228730 780 COSMIC
COSN5643688 939 COSMIC
COSN16085567 1402 COSMIC
COSN24481290 1593 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs770271223 1 dbSNP
rs746446326 3 dbSNP
rs781765820 4 dbSNP
rs762297334 12 dbSNP
rs14517 14 dbSNP
rs757726445 16 dbSNP
rs201845267 17 dbSNP
rs758586711 20 dbSNP
rs376258041 21 dbSNP
rs189868469 28 dbSNP
rs1443426526 31 dbSNP
rs750147640 33 dbSNP
rs1248597868 34 dbSNP
rs767453368 40 dbSNP
rs761774294 43 dbSNP
rs773776573 44 dbSNP
rs1223475590 45 dbSNP
rs201929693 46 dbSNP
rs1222028040 49 dbSNP
rs1322597645 50 dbSNP
rs762571563 51 dbSNP
rs1268387575 53 dbSNP
rs1197384815 54 dbSNP
rs1322865096 55 dbSNP
rs1292583795 57 dbSNP
rs1226992556 58 dbSNP
rs1356138752 59 dbSNP
rs1373775923 61 dbSNP
rs1475370610 69 dbSNP
rs1310418368 70 dbSNP
rs1449367229 82 dbSNP
rs1374866899 91 dbSNP
rs970040018 95 dbSNP
rs1302952606 98 dbSNP
rs1017208045 100 dbSNP
rs554152820 101 dbSNP
rs1006118786 125 dbSNP
rs1804855 129 dbSNP
rs1804857 135 dbSNP
rs887253876 139 dbSNP
rs1226565696 146 dbSNP
rs1025834698 150 dbSNP
rs1403515583 155 dbSNP
rs998230951 160 dbSNP
rs1246353535 162 dbSNP
rs901264856 165 dbSNP
rs1487619195 169 dbSNP
rs753460237 170 dbSNP
rs1159019225 184 dbSNP
rs1441161370 191 dbSNP
rs1207185311 195 dbSNP
rs1262476655 197 dbSNP
rs1446546822 208 dbSNP
rs1378037079 222 dbSNP
rs1186776279 227 dbSNP
rs1039724352 228 dbSNP
rs942739837 230 dbSNP
rs1163279657 233 dbSNP
rs1488496484 236 dbSNP
rs1456063136 240 dbSNP
rs534470023 241 dbSNP
rs779709886 242 dbSNP
rs1220065627 247 dbSNP
rs148580818 254 dbSNP
rs755596920 255 dbSNP
rs1287200933 256 dbSNP
rs1242699405 263 dbSNP
rs1351817221 271 dbSNP
rs1317994155 272 dbSNP
rs1384831622 274 dbSNP
rs1308754399 279 dbSNP
rs1043621776 285 dbSNP
rs1314102162 286 dbSNP
rs1369880907 293 dbSNP
rs1241422579 294 dbSNP
rs1261480128 300 dbSNP
rs1350263556 302 dbSNP
rs1206824832 303 dbSNP
rs1273141997 314 dbSNP
rs554905441 314 dbSNP
rs753138442 318 dbSNP
rs1434302099 323 dbSNP
rs1184128644 325 dbSNP
rs1254475960 326 dbSNP
rs1421301643 332 dbSNP
rs1160319385 336 dbSNP
rs1364813688 356 dbSNP
rs1298596048 357 dbSNP
rs1156299772 364 dbSNP
rs1407744452 366 dbSNP
rs913700164 371 dbSNP
rs1358263447 372 dbSNP
rs1376910967 378 dbSNP
rs538254845 379 dbSNP
rs1307442322 383 dbSNP
rs1335342654 387 dbSNP
rs1433385211 388 dbSNP
rs1265079064 392 dbSNP
rs1426727539 394 dbSNP
rs1324419515 395 dbSNP
rs987944517 396 dbSNP
rs1254723251 398 dbSNP
rs1481925514 400 dbSNP
rs939098169 402 dbSNP
rs750837377 407 dbSNP
rs1472057631 412 dbSNP
rs927755484 414 dbSNP
rs1430759952 420 dbSNP
rs980824933 423 dbSNP
rs1174778479 428 dbSNP
rs969108125 429 dbSNP
rs201391052 438 dbSNP
rs1298524934 449 dbSNP
rs878940716 450 dbSNP
rs951611557 451 dbSNP
rs375572928 457 dbSNP
rs185059619 462 dbSNP
rs998388053 464 dbSNP
rs181276509 471 dbSNP
rs1219292698 474 dbSNP
rs965435527 476 dbSNP
rs1018399921 479 dbSNP
rs1007400581 482 dbSNP
rs1482306289 484 dbSNP
rs904500952 490 dbSNP
rs1270540448 491 dbSNP
rs1211161324 495 dbSNP
rs1190060543 496 dbSNP
rs79039020 501 dbSNP
rs1010791196 505 dbSNP
rs146407864 508 dbSNP
rs1389298516 511 dbSNP
rs115128202 523 dbSNP
rs142345753 524 dbSNP
rs1436046229 527 dbSNP
rs1044789853 530 dbSNP
rs1364220870 531 dbSNP
rs751901284 543 dbSNP
rs1297449988 545 dbSNP
rs1340697917 549 dbSNP
rs766693815 550 dbSNP
rs1292972034 561 dbSNP
rs763196207 580 dbSNP
rs1220464214 584 dbSNP
rs73678318 585 dbSNP
rs951601836 587 dbSNP
rs12671052 590 dbSNP
rs976906012 594 dbSNP
rs530469636 595 dbSNP
rs1165177432 599 dbSNP
rs1288055355 614 dbSNP
rs1385697986 617 dbSNP
rs1404954525 621 dbSNP
rs7456156 624 dbSNP
rs1431517177 625 dbSNP
rs1319974427 626 dbSNP
rs1363568805 633 dbSNP
rs1455105678 634 dbSNP
rs544735214 635 dbSNP
rs1018877654 636 dbSNP
rs1006938677 637 dbSNP
rs1287249071 639 dbSNP
rs1318387262 641 dbSNP
rs1208735686 643 dbSNP
rs1173376225 646 dbSNP
rs1246897918 647 dbSNP
rs1468800119 649 dbSNP
rs934818581 651 dbSNP
rs1196532344 652 dbSNP
rs1243504238 654 dbSNP
rs969217265 655 dbSNP
rs1021621831 657 dbSNP
rs549976791 658 dbSNP
rs369900241 659 dbSNP
rs545143500 660 dbSNP
rs1203147490 661 dbSNP
rs1010235584 662 dbSNP
rs1318743848 662 dbSNP
rs528187247 663 dbSNP
rs1260045711 665 dbSNP
rs1471226877 665 dbSNP
rs77766999 671 dbSNP
rs1228692335 673 dbSNP
rs1340427767 673 dbSNP
rs755976917 673 dbSNP
rs879012671 673 dbSNP
rs1220454388 674 dbSNP
rs139054398 676 dbSNP
rs540475931 677 dbSNP
rs1205039314 679 dbSNP
rs1279192764 680 dbSNP
rs1294603603 685 dbSNP
rs1185063270 691 dbSNP
rs1234450206 693 dbSNP
rs1470631091 702 dbSNP
rs1181782467 710 dbSNP
rs1052328499 713 dbSNP
rs1481433915 714 dbSNP
rs1396348338 716 dbSNP
rs1003426396 717 dbSNP
rs1402039549 723 dbSNP
rs113155078 728 dbSNP
rs906351273 729 dbSNP
rs776907510 731 dbSNP
rs1355548761 732 dbSNP
rs190032872 737 dbSNP
rs1287266009 739 dbSNP
rs186366045 742 dbSNP
rs1224741560 743 dbSNP
rs1400466647 745 dbSNP
rs1274938427 749 dbSNP
rs1344196621 751 dbSNP
rs1172189295 761 dbSNP
rs1412115906 765 dbSNP
rs1048056408 767 dbSNP
rs1483290289 771 dbSNP
rs1336758308 780 dbSNP
rs1464525905 781 dbSNP
rs929656343 785 dbSNP
rs778807258 789 dbSNP
rs544617880 793 dbSNP
rs1199599536 794 dbSNP
rs1377197826 798 dbSNP
rs1477325144 804 dbSNP
rs764484557 814 dbSNP
rs1420875998 832 dbSNP
rs1429466735 832 dbSNP
rs965622552 833 dbSNP
rs1368257249 834 dbSNP
rs1254472650 836 dbSNP
rs1406448589 837 dbSNP
rs1323638235 838 dbSNP
rs1183269167 840 dbSNP
rs911361029 841 dbSNP
rs1271811511 842 dbSNP
rs986067641 847 dbSNP
rs1227315931 850 dbSNP
rs968830390 862 dbSNP
rs1022153392 866 dbSNP
rs575738322 869 dbSNP
rs988756784 873 dbSNP
rs559079322 875 dbSNP
rs1195456117 876 dbSNP
rs1249116691 877 dbSNP
rs1337396701 878 dbSNP
rs376569921 882 dbSNP
rs539101484 886 dbSNP
rs112203148 887 dbSNP
rs553090098 892 dbSNP
rs1023459871 895 dbSNP
rs1384528859 898 dbSNP
rs1365770966 902 dbSNP
rs1323338394 906 dbSNP
rs1012534174 911 dbSNP
rs888190219 916 dbSNP
rs1244877493 918 dbSNP
rs1048591622 925 dbSNP
rs929731351 928 dbSNP
rs536098118 929 dbSNP
rs1332810934 939 dbSNP
rs567548514 940 dbSNP
rs944265733 941 dbSNP
rs1464834428 948 dbSNP
rs181806847 949 dbSNP
rs1245329291 953 dbSNP
rs528848024 956 dbSNP
rs985631014 957 dbSNP
rs73275115 958 dbSNP
rs748916150 964 dbSNP
rs1367143015 970 dbSNP
rs1388820650 976 dbSNP
rs1456612977 979 dbSNP
rs753270651 983 dbSNP
rs1318516584 987 dbSNP
rs570873889 989 dbSNP
rs550982124 991 dbSNP
rs1311758750 996 dbSNP
rs1338913424 999 dbSNP
rs544864383 1017 dbSNP
rs1176891374 1020 dbSNP
rs1035619923 1022 dbSNP
rs1328637543 1027 dbSNP
rs1268123998 1029 dbSNP
rs777299628 1038 dbSNP
rs1483869288 1041 dbSNP
rs755864772 1044 dbSNP
rs1489421176 1047 dbSNP
rs528144778 1049 dbSNP
rs970668519 1052 dbSNP
rs1421684225 1059 dbSNP
rs1183951113 1060 dbSNP
rs1412036845 1062 dbSNP
rs752193928 1064 dbSNP
rs1221388774 1069 dbSNP
rs1360766984 1070 dbSNP
rs190053648 1073 dbSNP
rs1012179276 1089 dbSNP
rs1236394489 1095 dbSNP
rs888254656 1097 dbSNP
rs1411871068 1099 dbSNP
rs1026822533 1100 dbSNP
rs993884835 1110 dbSNP
rs1285292353 1111 dbSNP
rs896942528 1112 dbSNP
rs1301340262 1113 dbSNP
rs540814841 1117 dbSNP
rs1389096634 1120 dbSNP
rs1389116980 1123 dbSNP
rs1206344272 1125 dbSNP
rs1302935656 1137 dbSNP
rs1420652296 1138 dbSNP
rs1482531179 1140 dbSNP
rs767111395 1141 dbSNP
rs1179371832 1145 dbSNP
rs755448753 1149 dbSNP
rs1433666653 1152 dbSNP
rs1040732227 1158 dbSNP
rs752092043 1168 dbSNP
rs766718699 1169 dbSNP
rs1308418766 1172 dbSNP
rs187211637 1173 dbSNP
rs1408300942 1184 dbSNP
rs1295361099 1185 dbSNP
rs1050400771 1196 dbSNP
rs1299758715 1202 dbSNP
rs1386685297 1202 dbSNP
rs947678934 1202 dbSNP
rs561543897 1203 dbSNP
rs1274442657 1204 dbSNP
rs544955878 1205 dbSNP
rs531028846 1215 dbSNP
rs934737215 1216 dbSNP
rs928761491 1217 dbSNP
rs1488491556 1218 dbSNP
rs879090682 1231 dbSNP
rs1201008995 1232 dbSNP
rs1265100194 1235 dbSNP
rs1451271748 1237 dbSNP
rs981388773 1240 dbSNP
rs181918652 1242 dbSNP
rs1428031918 1244 dbSNP
rs763230371 1246 dbSNP
rs376034566 1247 dbSNP
rs1221505807 1251 dbSNP
rs1350710423 1251 dbSNP
rs1291871656 1253 dbSNP
rs1367956875 1272 dbSNP
rs1436547894 1275 dbSNP
rs149263171 1279 dbSNP
rs1488516472 1293 dbSNP
rs138476812 1300 dbSNP
rs545428959 1304 dbSNP
rs1291526269 1308 dbSNP
rs991105944 1309 dbSNP
rs1220115666 1314 dbSNP
rs565512700 1315 dbSNP
rs1466199130 1316 dbSNP
rs1349493989 1319 dbSNP
rs1026812650 1321 dbSNP
rs1234707506 1323 dbSNP
rs767854396 1335 dbSNP
rs1247160579 1347 dbSNP
rs188399154 1349 dbSNP
rs536425068 1355 dbSNP
rs1414722177 1360 dbSNP
rs1401123526 1364 dbSNP
rs1342844404 1366 dbSNP
rs1390972077 1374 dbSNP
rs1458205396 1375 dbSNP
rs567380722 1376 dbSNP
rs1320412455 1378 dbSNP
rs1296733087 1386 dbSNP
rs556749983 1387 dbSNP
rs1450550380 1392 dbSNP
rs536918385 1394 dbSNP
rs1019406070 1401 dbSNP
rs1379430783 1402 dbSNP
rs1007988272 1408 dbSNP
rs1290871286 1412 dbSNP
rs889424389 1421 dbSNP
rs571208786 1422 dbSNP
rs1267385437 1423 dbSNP
rs1445217525 1426 dbSNP
rs150135839 1427 dbSNP
rs1237906032 1429 dbSNP
rs893422814 1430 dbSNP
rs1464572896 1432 dbSNP
rs545599191 1436 dbSNP
rs528116971 1445 dbSNP
rs1053213150 1448 dbSNP
rs1198663662 1458 dbSNP
rs934853354 1468 dbSNP
rs1158525451 1469 dbSNP
rs1387012843 1472 dbSNP
rs1265143673 1473 dbSNP
rs1416710506 1479 dbSNP
rs1335270898 1481 dbSNP
rs928710489 1483 dbSNP
rs1310652072 1488 dbSNP
rs1045770366 1497 dbSNP
rs768886750 1499 dbSNP
rs759493414 1513 dbSNP
rs984844253 1516 dbSNP
rs1201787857 1517 dbSNP
rs774165238 1518 dbSNP
rs1320865305 1522 dbSNP
rs1261956043 1523 dbSNP
rs952737437 1531 dbSNP
rs1483511580 1532 dbSNP
rs1181532403 1536 dbSNP
rs141748661 1538 dbSNP
rs7779937 1551 dbSNP
rs1425116852 1557 dbSNP
rs1413086399 1563 dbSNP
rs1268801822 1573 dbSNP
rs1170886015 1579 dbSNP
rs1371964907 1581 dbSNP
rs530300172 1582 dbSNP
rs1019479568 1595 dbSNP
rs1333525429 1607 dbSNP
rs1341331525 1614 dbSNP
rs1275330924 1621 dbSNP
rs1344222669 1625 dbSNP
rs561433627 1628 dbSNP
rs553495761 1630 dbSNP
rs1028400928 1631 dbSNP
rs1343137316 1636 dbSNP
rs1405512579 1638 dbSNP
rs879299170 1639 dbSNP
rs1248483674 1641 dbSNP
rs1453351955 1649 dbSNP
rs1466079839 1653 dbSNP
rs773805048 1660 dbSNP
rs1425614644 1668 dbSNP
rs1246571904 1673 dbSNP
rs1453134774 1677 dbSNP
rs1165959677 1690 dbSNP
rs6966270 1692 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions A549
Location of target site 3'UTR
Tools used in this research MicroCosm , TargetScan
Original Description (Extracted from the article) ... "Interestingly ...

- Bertero T; Grosso S; Robbe-Sermesant K; et al., 2012, PloS one.

Article - Bertero T; Grosso S; Robbe-Sermesant K; et al.
- PloS one, 2012
Specificity of interaction between a microRNA (miRNA) and its targets crucially depends on the seed region located in its 5'-end. It is often implicitly considered that two miRNAs sharing the same biological activity should display similarity beyond the strict six nucleotide region that forms the seed, in order to form specific complexes with the same mRNA targets. We have found that expression of hsa-miR-147b and hsa-miR-210, though triggered by different stimuli (i.e. lipopolysaccharides and hypoxia, respectively), induce very similar cellular effects in term of proliferation, migration and apoptosis. Hsa-miR-147b only shares a "minimal" 6-nucleotides seed sequence with hsa-miR-210, but is identical with hsa-miR-147a over 20 nucleotides, except for one base located in the seed region. Phenotypic changes induced after heterologous expression of miR-147a strikingly differ from those induced by miR-147b or miR-210. In particular, miR-147a behaves as a potent inhibitor of cell proliferation and migration. These data fit well with the gene expression profiles observed for miR-147b and miR-210, which are very similar, and the gene expression profile of miR-147a, which is distinct from the two others. Bioinformatics analysis of all human miRNA sequences indicates multiple cases of miRNAs from distinct families exhibiting the same kind of similarity that would need to be further characterized in terms of putative functional redundancy. Besides, it implies that functional impact of some miRNAs can be masked by robust expression of miRNAs belonging to distinct families.
LinkOut: [PMID: 23028679]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions A549 , HeLa , NCI-H1975
Disease 4697.0
Location of target site 3'UTR
Tools used in this research TargetScan
Original Description (Extracted from the article) ... "Transfection of NDUFA4 and SDHD 3'-untranslated region (UTR) pSiCheck-2 constructs showed a reproducible reduction of luciferase activity in pmiR-210 cells compared with pmiR-Ctl cells ...

- Grosso S; Doyen J; Parks SK; Bertero T; et al., 2013, Cell death & disease.

Article - Grosso S; Doyen J; Parks SK; Bertero T; et al.
- Cell death & disease, 2013
The resistance of hypoxic cells to radiotherapy and chemotherapy is a major problem in the treatment of cancer. Recently, an additional mode of hypoxia-inducible factor (HIF)-dependent transcriptional regulation, involving modulation of a specific set of micro RNAs (miRNAs), including miR-210, has emerged. We have recently shown that HIF-1 induction of miR-210 also stabilizes HIF-1 through a positive regulatory loop. Therefore, we hypothesized that by stabilizing HIF-1 in normoxia, miR-210 may protect cancer cells from radiation. We developed a non-small cell lung carcinoma (NSCLC)-derived cell line (A549) stably expressing miR-210 (pmiR-210) or a control miRNA (pmiR-Ctl). The miR-210-expressing cells showed a significant stabilization of HIF-1 associated with mitochondrial defects and a glycolytic phenotype. Cells were subjected to radiation levels ranging from 0 to 10 Gy in normoxia and hypoxia. Cells expressing miR-210 in normoxia had the same level of radioresistance as control cells in hypoxia. Under hypoxia, pmiR-210 cells showed a low mortality rate owing to a decrease in apoptosis, with an ability to grow even at 10 Gy. This miR-210 phenotype was reproduced in another NSCLC cell line (H1975) and in HeLa cells. We have established that radioresistance was independent of p53 and cell cycle status. In addition, we have shown that genomic double-strand breaks (DSBs) foci disappear faster in pmiR-210 than in pmiR-Ctl cells, suggesting that miR-210 expression promotes a more efficient DSB repair. Finally, HIF-1 invalidation in pmiR-210 cells removed the radioresistant phenotype, showing that this mechanism is dependent on HIF-1. In conclusion, miR-210 appears to be a component of the radioresistance of hypoxic cancer cells. Given the high stability of most miRNAs, this advantage could be used by tumor cells in conditions where reoxygenation has occurred and suggests that strategies targeting miR-210 could enhance tumor radiosensitization.
LinkOut: [PMID: 23492775]
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
LUSC -0.445 0 -0.380 0.01 38 Click to see details
THCA -0.287 0.01 -0.314 0.01 59 Click to see details
PCPG -0.999 0.01 -0.500 0.33 3 Click to see details
UCEC -0.502 0.01 -0.605 0 19 Click to see details
STAD -0.355 0.02 -0.260 0.08 32 Click to see details
HNSC -0.295 0.03 -0.224 0.08 42 Click to see details
CHOL -0.632 0.03 -0.617 0.04 9 Click to see details
COAD -0.643 0.04 -0.619 0.05 8 Click to see details
PAAD -0.907 0.05 -0.800 0.1 4 Click to see details
PRAD -0.226 0.06 -0.173 0.11 50 Click to see details
KIRC 0.175 0.08 0.195 0.06 68 Click to see details
BLCA -0.35 0.08 -0.404 0.05 18 Click to see details
LIHC -0.095 0.26 -0.064 0.33 49 Click to see details
KIRP -0.115 0.27 -0.093 0.31 32 Click to see details
CESC 0.504 0.33 0.500 0.33 3 Click to see details
LUAD -0.096 0.38 -0.189 0.28 12 Click to see details
ESCA -0.086 0.4 -0.073 0.42 11 Click to see details
KICH 0.033 0.44 -0.026 0.45 25 Click to see details
BRCA 0.009 0.47 -0.079 0.24 84 Click to see details
BRCA 0.009 0.47 -0.079 0.24 84 Click to see details
BRCA 0.009 0.47 -0.079 0.24 84 Click to see details
126 hsa-miR-210-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT000149 HOXA9 homeobox A9 4 1
MIRT000150 TP53I11 tumor protein p53 inducible protein 11 2 1
MIRT000151 PIM1 Pim-1 proto-oncogene, serine/threonine kinase 2 1
MIRT000152 HOXA1 homeobox A1 2 1
MIRT000153 FGFRL1 fibroblast growth factor receptor like 1 6 3
MIRT000156 RAD52 RAD52 homolog, DNA repair protein 5 3
MIRT001930 NPTX1 neuronal pentraxin 1 3 2
MIRT002024 EFNA3 ephrin A3 8 8
MIRT003153 BDNF brain derived neurotrophic factor 5 1
MIRT003154 PTPN1 protein tyrosine phosphatase, non-receptor type 1 5 1
MIRT003155 P4HB prolyl 4-hydroxylase subunit beta 6 2
MIRT003156 UBQLN1 ubiquilin 1 3 1
MIRT003157 SERTAD2 SERTA domain containing 2 3 1
MIRT003158 SEH1L SEH1 like nucleoporin 3 1
MIRT003159 NCAM1 neural cell adhesion molecule 1 4 1
MIRT003160 MID1IP1 MID1 interacting protein 1 3 1
MIRT003161 MDGA1 MAM domain containing glycosylphosphatidylinositol anchor 1 3 1
MIRT003162 KIAA1161 myogenesis regulating glycosidase (putative) 3 1
MIRT003163 ISCU iron-sulfur cluster assembly enzyme 6 7
MIRT003164 HOXA3 homeobox A3 3 1
MIRT003165 GPD1L glycerol-3-phosphate dehydrogenase 1 like 7 2
MIRT003166 DENND6A DENN domain containing 6A 3 1
MIRT003167 CPEB2 cytoplasmic polyadenylation element binding protein 2 5 1
MIRT003168 CDK10 cyclin dependent kinase 10 3 1
MIRT003169 ABCB9 ATP binding cassette subfamily B member 9 3 1
MIRT003170 CBX1 chromobox 1 3 1
MIRT003171 XIST X inactive specific transcript (non-protein coding) 4 1
MIRT003172 TNPO1 transportin 1 3 1
MIRT003173 SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 3 1
MIRT003174 PTAR1 protein prenyltransferase alpha subunit repeat containing 1 3 1
MIRT003175 NIPBL NIPBL, cohesin loading factor 3 1
MIRT003176 MIB1 mindbomb E3 ubiquitin protein ligase 1 3 1
MIRT003177 HECTD1 HECT domain E3 ubiquitin protein ligase 1 3 1
MIRT003178 ELK3 ELK3, ETS transcription factor 3 1
MIRT003179 DDAH1 dimethylarginine dimethylaminohydrolase 1 4 1
MIRT003180 CLASP2 cytoplasmic linker associated protein 2 3 1
MIRT003181 CHD9 chromodomain helicase DNA binding protein 9 3 1
MIRT003182 ATP11C ATPase phospholipid transporting 11C 3 1
MIRT003183 APC APC, WNT signaling pathway regulator 3 1
MIRT003184 E2F3 E2F transcription factor 3 7 5
MIRT003185 ACVR1B activin A receptor type 1B 2 1
MIRT003916 MRE11A MRE11 homolog, double strand break repair nuclease 2 1
MIRT003917 XPA XPA, DNA damage recognition and repair factor 2 1
MIRT004672 MNT MAX network transcriptional repressor 4 2
MIRT006326 AIFM3 apoptosis inducing factor, mitochondria associated 3 3 2
MIRT006519 CASP8AP2 caspase 8 associated protein 2 4 1
MIRT006663 VMP1 vacuole membrane protein 1 3 2
MIRT006830 TFRC transferrin receptor 3 2
MIRT047002 PFDN2 prefoldin subunit 2 1 1
MIRT047003 U2AF2 U2 small nuclear RNA auxiliary factor 2 1 1
MIRT047004 UBA1 ubiquitin like modifier activating enzyme 1 1 1
MIRT047005 ESPL1 extra spindle pole bodies like 1, separase 1 1
MIRT047006 ACTR1A ARP1 actin related protein 1 homolog A 1 1
MIRT047007 SCN1B sodium voltage-gated channel beta subunit 1 1 1
MIRT047008 RCC2 regulator of chromosome condensation 2 1 1
MIRT053179 HSD17B1 hydroxysteroid 17-beta dehydrogenase 1 2 1
MIRT054098 NDUFA4 NDUFA4, mitochondrial complex associated 4 2
MIRT054099 SDHD succinate dehydrogenase complex subunit D 6 4
MIRT054141 STMN1 stathmin 1 3 1
MIRT054142 DIMT1L DIM1 dimethyladenosine transferase 1 homolog 4 2
MIRT054186 ROD1 polypyrimidine tract binding protein 3 3 1
MIRT054203 ALDH5A1 aldehyde dehydrogenase 5 family member A1 4 1
MIRT054204 FOXN3 forkhead box N3 5 2
MIRT054205 MCM3 minichromosome maintenance complex component 3 4 1
MIRT054206 IGFBP3 insulin like growth factor binding protein 3 6 2
MIRT054207 COL4A2 collagen type IV alpha 2 chain 6 2
MIRT054208 INPP5A inositol polyphosphate-5-phosphatase A 4 1
MIRT054209 EHD2 EH domain containing 2 4 1
MIRT054210 SH3BGRL SH3 domain binding glutamate rich protein like 5 2
MIRT054248 PTPN2 protein tyrosine phosphatase, non-receptor type 2 3 1
MIRT054321 LDHA lactate dehydrogenase A 2 1
MIRT054324 LDHB lactate dehydrogenase B 2 1
MIRT054349 HIF1A hypoxia inducible factor 1 alpha subunit 5 2
MIRT054714 FOXP3 forkhead box P3 3 1
MIRT054794 HIF3A hypoxia inducible factor 3 alpha subunit 3 1
MIRT115688 MGRN1 mahogunin ring finger 1 2 3
MIRT170674 INSIG1 insulin induced gene 1 1 1
MIRT437785 BNIP3 BCL2 interacting protein 3 5 2
MIRT438739 KCMF1 potassium channel modulatory factor 1 1 1
MIRT439407 TNPO3 transportin 3 1 1
MIRT439629 SIPA1L3 signal induced proliferation associated 1 like 3 1 1
MIRT439632 SIN3A SIN3 transcription regulator family member A 1 1
MIRT439740 RPL22 ribosomal protein L22 1 1
MIRT439886 PSAP prosaposin 1 1
MIRT439918 PPP1R2 protein phosphatase 1 regulatory inhibitor subunit 2 1 1
MIRT439928 POU2AF1 POU class 2 associating factor 1 1 1
MIRT440033 ICMT isoprenylcysteine carboxyl methyltransferase 2 3
MIRT440255 MEF2D myocyte enhancer factor 2D 1 1
MIRT440491 HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 2 3
MIRT440570 GIT2 GIT ArfGAP 2 1 1
MIRT440647 FCHSD2 FCH and double SH3 domains 2 1 1
MIRT440830 DEAF1 DEAF1, transcription factor 1 1
MIRT440866 CSNK1E casein kinase 1 epsilon 1 1
MIRT472232 NFIC nuclear factor I C 2 2
MIRT473190 MITF melanogenesis associated transcription factor 2 2
MIRT477856 DYRK2 dual specificity tyrosine phosphorylation regulated kinase 2 2 2
MIRT497528 ZNF607 zinc finger protein 607 2 2
MIRT509770 SERTM1 serine rich and transmembrane domain containing 1 2 6
MIRT524407 CNTNAP5 contactin associated protein like 5 2 4
MIRT535209 PKIA cAMP-dependent protein kinase inhibitor alpha 2 4
MIRT554511 RUNX1T1 RUNX1 translocation partner 1 2 4
MIRT558069 ESCO2 establishment of sister chromatid cohesion N-acetyltransferase 2 2 2
MIRT572273 KCNJ6 potassium voltage-gated channel subfamily J member 6 2 2
MIRT574255 DOCK7 dedicator of cytokinesis 7 2 4
MIRT575621 Foxn3 forkhead box N3 2 2
MIRT575742 Zfp618 zinc finger protein 618 1 1
MIRT609050 VAMP4 vesicle associated membrane protein 4 2 2
MIRT611143 TNRC6B trinucleotide repeat containing 6B 2 4
MIRT699226 SLCO3A1 solute carrier organic anion transporter family member 3A1 2 2
MIRT703060 GTDC1 glycosyltransferase like domain containing 1 2 2
MIRT716005 ASB11 ankyrin repeat and SOCS box containing 11 2 2
MIRT731682 BTK Bruton tyrosine kinase 3 1
MIRT733090 DLEU2L deleted in lymphocytic leukemia 2-like 3 0
MIRT733091 BRCA2 BRCA2, DNA repair associated 3 0
MIRT733156 ITGA5 integrin subunit alpha 5 1 0
MIRT733501 GATA1 GATA binding protein 1 3 0
MIRT733503 SMAD2 SMAD family member 2 3 0
MIRT733525 MIR210HG MIR210 host gene 2 0
MIRT733615 TGFBI transforming growth factor beta induced 2 0
MIRT734175 KRAS KRAS proto-oncogene, GTPase 2 0
MIRT734293 PTEN phosphatase and tensin homolog 1 0
MIRT734568 STAT6 signal transducer and activator of transcription 6 1 0
MIRT734966 ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif 6 1 0
MIRT736294 ID2 inhibitor of DNA binding 2, HLH protein 1 0
MIRT737104 FABP4 fatty acid binding protein 4, adipocyte 3 0
MIRT756028 NTN4 netrin 4 3 1
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-210 Vincristine approved 5978 Quantitative real-time PCR Hep-2 cells 23780424 2013 up-regualted
miR-210 Lenalidomide approved 216326 Quantitative real-time PCR peripheral blood CD14+ monocytes 25287904 2014 down-regulated
miR-210 Arsenic trioxide approved 14888 Microarray lymphoblast cell line TK-6 17108120 2006 down-regulated
miR-210 5-Fluorouracil approved 3385 Quantitative real-time PCR colon cancer cells 17702597 2007 down-regulated
miR-210 Arsenic trioxide approved 14888 Microarray HepG-2 human hepatocellular carcinoma cell line 21175813 2011 up-regulated
miR-210 Arsenic trioxide approved 14888 Quantitative real-time PCR HepG-2 human hepatocellular carcinoma cell line 21175813 2011 up-regulated
miR-210 Arsenic trioxide approved 14888 Quantitative real-time PCR HepG-2 human hepatocellular carcinoma cell line 21175813 2011 up-regulated
miR-210 Ginsenoside Rh2 NULL 119307 Microarray human glioma cells U251 21372826 2011 down-regulated
miR-210 Aidi injection NULL NULL Microarray human breast cancer cells 21563499 2011 down-regulated
miR-210 5-aza-2'-deoxycytidine (5-Aza-CdR) approved 451668 Microarray breast cancer HB2 22076154 2011 down-regulated
miR-210 5-aza-2'-deoxycytidine (5-Aza-CdR) approved 451668 Microarray breast cancer MDA-MB231 22076154 2011 down-regulated
miR-210 5-aza-2'-deoxycytidine (5-Aza-CdR) approved 451668 Microarray breast cancer SKBR3 22076154 2011 down-regulated
miR-210 Trastuzumab approved NULL Microarray HER2-positive breast cancer 22384020 2012 down-regulated
miR-210 Trastuzumab approved NULL Quantitative real-time PCR HER2-positive breast cancer 22384020 2012 down-regulated
miR-210 Trastuzumab approved NULL Microarray BT474 cells 22384020 2012 down-regulated
miR-210 Curcumin NULL 969516 Quantitative real-time PCR Y79 RB cells. 22510010 2012 down-regulated
miR-210 Bicalutamide approved 2375 Microarray prostate 22674191 2012 down-regulated
miR-210 Goserelin approved 47725 Microarray prostate 22674191 2012 down-regulated
miR-210 Olea europaea leaf extract NULL NULL Quantitative real-time PCR glioblastoma cells. 22722712 2012 up-regulated
miR-210 Temozolomide approved 5394 Quantitative real-time PCR glioblastoma cells. 22722712 2012 up-regulated
miR-210 Nicotine approved 89594 Microarray Rat adrenal pheochromocytoma PC12 cell 18845019 2009 down-regulated
miR-210 Comfrey NULL 6440495 Microarray rat liver 21370286 2011 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-210 Cisplatin 5460033 NSC119875 approved resistant High Gastric Cancer cell line (BGC823)
hsa-mir-210 Ceritinib 57379345 NSC776422 approved resistant High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-mir-210 Dabrafenib 44462760 NSC764134 approved resistant cell line (A375)
hsa-mir-210 Paclitaxel 36314 NSC125973 approved resistant cell line (W1)
hsa-mir-210 Androstenedione 6128 NSC9563 sensitive cell line (MCF-7)
hsa-mir-210 Androstenedione+Letrozole sensitive cell line (MCF-7)
hsa-mir-210 Tamoxifen 2733525 NSC180973 approved resistant tissue (ER-positive breast cancer)
hsa-mir-210 Fluorouracil 3385 NSC19893 approved sensitive cell line (OE19)
hsa-mir-210 Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)
hsa-mir-210 Cisplatin 5460033 NSC119875 approved resistant cell line (BGC-823)
hsa-miR-210-3p (E)-1-[3,5-bis[(dimethylamino)methyl]-4-hydroxyphenyl]-3-phenylprop-2-en-1-one 6374691 NSC677784 resistant
hsa-miR-210-3p (e)-3-chloro-3-(4-methoxyphenyl)-2-(4-nitrophenyl)prop-2-enal 5387396 NSC623175 resistant
hsa-miR-210-3p [(E)-(1-chloro-2-methylpropylidene)amino] N-anilinocarbamate 5494354 NSC682841 resistant
hsa-miR-210-3p [(E)-1-chloropropylideneamino] N-[2-(trifluoromethoxy)phenyl]carbamate 5466266 NSC682836 resistant
hsa-miR-210-3p [2-[(e)-(carbamothioylhydrazono)methyl]-6-methoxy-phenoxy]-hydroxy-copper; 2-(2-pyridyl)pyridine 135484845 NSC638302 resistant
hsa-miR-210-3p 1-(4-ethoxyphenyl)-3-(2-methyl-5-propan-2-ylphenyl)urea 240168 NSC46213 sensitive
hsa-miR-210-3p 1-(4-nitrophenyl)-3-(2-pyridyl)thiourea 3005383 NSC695329 sensitive
hsa-miR-210-3p 1-(naphthalen-1-ylmethyl)-4-[1-(naphthalen-1-ylmethyl)piperidin-4-yl]piperidine 364095 NSC669995 resistant
hsa-miR-210-3p 1-[2-(4-nitrophenyl)-2-oxoethyl]-4-pentylpyridin-1-ium bromide 24181037 NSC4290 resistant
hsa-miR-210-3p 11-(3-methoxyphenyl)-2,12,15-triazapentacyclo[11.7.1.03,8.09,21.014,19]henicosa-1,3,5,7,9,11,13(21),14(19),15,17-decaen-20-one 54608964 NSC697747 resistant
hsa-miR-210-3p 17-acetyl-9,14-dihydroxy-16-methyl-15-(4-methylphenyl)-15-azatetracyclo[8.7.0.01,14.03,8]heptadeca-3,5,7,9,12,16-hexaene-2,11-dione 405612 NSC722982 resistant
hsa-miR-210-3p 1h-benz[g]indol-5-ol, 2-phenyl 371327 NSC645431 resistant
hsa-miR-210-3p 2-[[4-anilino-5-[8-[4-anilino-5-[(1-hydroxynaphthalen-2-yl)oxymethyl]-1,2,4-triazol-3-yl]octyl]-1,2,4-triazol-3-yl]methoxy]naphthalen-1-ol 394049 NSC697167 resistant
hsa-miR-210-3p 2-[9-[(7-oxocyclohepta-1,3,5-trien-1-yl)amino]nonylamino]cyclohepta-2,4,6-trien-1-one 358331 NSC618296 resistant
hsa-miR-210-3p 2-amino-5,8-dihydroxy-1,4-naphthoquinone 377209 NSC658441 resistant
hsa-miR-210-3p 2-bromo-4-(5-fluoro-1,3-benzothiazol-2-yl)aniline 399248 NSC709925 sensitive
hsa-miR-210-3p 2-hydroxy-5-({(e)-[(10-hydroxyacridin-9(10h)-ylidene)methyl]diazenyl}sulfonyl)benzoic acid 363212 NSC627890 resistant
hsa-miR-210-3p 3'-chloro-3-nitro-o-salicylotoluidide 332278 NSC328477 resistant
hsa-miR-210-3p 3-((4-(methylthio)phenoxy)methyl)-2-oxiranol 366923 NSC636087 resistant
hsa-miR-210-3p 4-(2-phenylethylamino)naphthalene-1,2-dione 367789 NSC637731 resistant
hsa-miR-210-3p 4-[(E)-2-piperidin-1-ylethenyl]benzo[g]quinoline-5,10-dione 5781544 NSC642968 resistant
hsa-miR-210-3p 4-[(r)-[(2s,5r)-2,5-dimethyl-4-prop-2-enylpiperazin-1-yl]-(3-methoxyphenyl)methyl]-n-pentan-3-ylbenzamide;hydrochloride 5471112 NSC708822 resistant
hsa-miR-210-3p 4-[2-(methylamino)-1-methylsulfanylethyl]benzene-1,2-diol 412349 NSC39215 resistant
hsa-miR-210-3p 4-[4-(4-sulfinobutyldisulfanyl)butyldisulfanyl]butane-1-sulfinic acid 361262 NSC624205 resistant
hsa-miR-210-3p 4-acetamido-n-[(e)-(2,4-dichlorophenyl)methylideneamino]-2-methoxybenzamide 9572428 NSC716142 sensitive
hsa-miR-210-3p 4-aminodithiolane-4-carboxylic acid 269217 NSC109825 resistant
hsa-miR-210-3p 4-hydroxy-3-[1-(1-hydroxy-3,4-dioxonaphthalen-2-yl)-3-phenylpropyl]naphthalene-1,2-dione 272651 NSC117274 resistant
hsa-miR-210-3p 4,4-dimethylspiro[1,3,2-oxazaphospholidin-2-ium-2,2'-3h-1,3,2-benzoxazaphosphol-2-ium]-5-one 6330525 NSC351866 resistant
hsa-miR-210-3p 4b-hydroxy-10,10-dimethoxy-9ah-indeno[1,2-a]inden-9-one 363252 NSC628000 resistant
hsa-miR-210-3p 4h,7h-furo[2',3',4':4,5]naphth[2,1-e][1,3]oxazin-4-one, 8-(4-chlorophenyl)-8,9-dihydro- 373969 NSC651001 resistant
hsa-miR-210-3p 5,6,7-trimethoxy-N-(4H-pyrazolo[1,5-a]indol-2-yl)-1H-indole-2-carboxamide 404173 NSC720326 resistant
hsa-miR-210-3p 6-(3-chloropropyl)-3-nitroindeno[1,2-c]isoquinoline-5,11-dione 17755848 NSC731154 resistant
hsa-miR-210-3p 6-benzyloxyhexanal 389877 NSC686505 resistant
hsa-miR-210-3p 7-[(E)-2-(1,6-dimethylquinolin-1-ium-2-yl)ethenyl]-5-methylquinolin-8-ol 135483953 NSC86371 resistant
hsa-miR-210-3p 7-[(naphthalen-1-ylamino)(phenyl)methyl]quinolin-8-ol 256754 NSC84092 resistant
hsa-miR-210-3p 7-chloro-6-n-(2-fluoroethylamino)-5,8-quinolinedione 379079 NSC663286 resistant
hsa-miR-210-3p 7-o,8-o-isopropylidene iriomoteolide 3a 24808220 NSC753164 resistant
hsa-miR-210-3p 9h-quino[4,3,2-de][1,10]phenanthrolin-9-one, 2-phenyl- 4567749 NSC686553 resistant
hsa-miR-210-3p Acetyltrophanthidin 261075 NSC92954 resistant
hsa-miR-210-3p Adenosine, 2-bromo-2'-deoxy- 334838 NSC341936 resistant
hsa-miR-210-3p Asimicinone 393461 NSC695394 resistant
hsa-miR-210-3p Benzo[b]naphtho[2,3-d]furan-6,11-dione, 4-chloro-3-hydroxy 371025 NSC644902 resistant
hsa-miR-210-3p Benzo[g]pteridine-2,4(3h,10h)-dione, 10-(2,4-dimethylphenyl)-3-methyl- 363228 NSC627974 resistant
hsa-miR-210-3p Benzo[g]pteridine-2,4(3h,10h)-dione, 10-(4-chlorophenyl)-3,7,8-trimethyl- 363246 NSC627992 resistant
hsa-miR-210-3p Benzo[g]pteridine-2,4(3h,10h)-dione, 3-methyl-10-[3-(methylthio)phenyl]- 363242 NSC627988 resistant
hsa-miR-210-3p Benzo[g]quinoxaline-5,10-dione, 5,10-dihydro-2,3-dimethyl- 353644 NSC602617 resistant
hsa-miR-210-3p Celcot rm 67277 NSC37168 resistant
hsa-miR-210-3p Cytarabine 6253 NSC287459 approved resistant
hsa-miR-210-3p Destruxin a 122810 NSC361126 resistant
hsa-miR-210-3p Di-p-tolyliodinium bromide 54601177 NSC8985 resistant
hsa-miR-210-3p Diethoxybis(1,4-naphthochinone-2-olato)titanium(iv) 368297 NSC638842 resistant
hsa-miR-210-3p Dihydrorotenone 243725 NSC53866 resistant
hsa-miR-210-3p Diisopropoxybis(1,4-naphthochinone-2-olato)titanium(iv) 368058 NSC638383 resistant
hsa-miR-210-3p Discorhabdin i 135409047 NSC656206 resistant
hsa-miR-210-3p Dpbq 364074 NSC629713 resistant
hsa-miR-210-3p Ethyl 6-chloro-4-phenyl-2-(piperazin-1-ylmethyl)quinoline-3-carboxylate 369623 NSC641536 resistant
hsa-miR-210-3p Ethyl 6-hydroxy-4-(4-methoxyphenyl)-6-methyl-3-oxo-2-phenyl-1,4,5,7-tetrahydroindazole-5-carboxylate 392845 NSC693857 resistant
hsa-miR-210-3p Gnmlngdfmleynr-uhfffaoysa-n 402862 NSC717147 sensitive
hsa-miR-210-3p Gw612286x 9822610 NSC756278 sensitive
hsa-miR-210-3p Gw811761x 6539382 NSC756375 sensitive
hsa-miR-210-3p Herbimycin 6436247 NSC305978 resistant
hsa-miR-210-3p Hypothemycin 5458809 NSC354462 resistant
hsa-miR-210-3p Indole-2,3-dione, 5-methyl-, 3-[(o-nitrophenyl)hydrazone] 3632950 NSC117915 sensitive
hsa-miR-210-3p J3.572.907k 396709 NSC703318 resistant
hsa-miR-210-3p Methyl 10-acetyl-3-(4-methylphenyl)sulfonyl-9-(2-methylprop-1-enyl)-3,10-diazatricyclo[6.4.1.04,13]trideca-1,4,6,8(13),11-pentaene-11-carboxylate NSC621968 resistant
hsa-miR-210-3p Methyl 8-[(4-chlorophenyl)carbamoyl]naphthalene-1-carboxylate 364289 NSC630307 resistant
hsa-miR-210-3p N-(2-morpholin-4-ylethyl)-5-nitroquinolin-4-amine;hydrochloride 372042 NSC646859 resistant
hsa-miR-210-3p N-(3-chloro-1,4-dioxonaphthalen-2-yl)-4-naphthalen-2-yl-2,4-dioxo-3-(3-oxo-1H-2-benzofuran-1-yl)butanamide 369463 NSC641233 resistant
hsa-miR-210-3p N-(3,5-dicyano-2-(4-methylphenyl)-6-oxo-4-phenyl-1(6h)-pyridinyl)-4-methylbenzenesulfonamide 390286 NSC687578 resistant
hsa-miR-210-3p N-[(1E)-1-(1-hydroxypyridin-2-ylidene)ethyl]iminoazepane-1-carbothioamide 5369124 NSC351075 resistant
hsa-miR-210-3p N-[1,1,1,3,3,3-hexafluoro-2-(4-fluoroanilino)propan-2-yl]butanamide 389152 NSC684836 resistant
hsa-miR-210-3p Naphtho[2,3-d]-1,3-dioxepin-6,11-dione, 4-methyl- NSC626868 resistant
hsa-miR-210-3p Naphtho[2,3-d]oxazole-4,9-dione, 2-(1,1-dimethylethyl)- 370622 NSC643915 resistant
hsa-miR-210-3p Niosh/br9826000 359483 NSC620462 resistant
hsa-miR-210-3p NSC619321 NSC619321 sensitive
hsa-miR-210-3p NSC621321 NSC621321 resistant
hsa-miR-210-3p NSC631451 NSC631451 resistant
hsa-miR-210-3p NSC634766 NSC634766 resistant
hsa-miR-210-3p NSC635414 NSC635414 resistant
hsa-miR-210-3p Pentyl 6-(chloromethyl)-2-oxo-2h-chromene-3-carboxylate 402498 NSC716524 resistant
hsa-miR-210-3p Pmp (van) 72508 NSC1906 resistant
hsa-miR-210-3p Scillirosidin, glycoside 222160 NSC7534 resistant
hsa-miR-210-3p Sesbanimide 163490 NSC355461 resistant
hsa-miR-210-3p Snc 80 123924 NSC707484 resistant
hsa-miR-210-3p Streptovaricin b 135443622 NSC156215 resistant
hsa-miR-210-3p Tetratert-butyl 8,11-dimethoxytricyclo[4.3.3.01,6]dodeca-7,10-diene-7,9,10,12-tetracarboxylate 362411 NSC626176 resistant
hsa-miR-210-3p Tolonium chloride 7083 NSC36758 resistant
hsa-miR-210-3p Z48861686 4784054 NSC745813 resistant
hsa-miR-210-3p Doxorubicin 31703 NSC123127 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-210-3p Doxorubicin 31703 NSC123127 approved sensitive High Breast Cancer cell line (MCF-7)
hsa-miR-210-3p Temozolomide 5394 NSC362856 approved resistant High Glioblastoma cell line (U251MG, U251R, U87MG, M059K, M059J)
hsa-miR-210-3p Imatinib 5291 NSC743414 approved resistant High Myelogenous Leukemia cell line (MYL)
hsa-miR-210-3p Methotrexate 126941 NSC740 approved resistant High Colon Cancer cell line (HT-29)
hsa-miR-210-3p Methotrexate 126941 NSC740 approved resistant High Colon Cancer cell line (HT-29)
hsa-miR-210-3p Cisplatin 5460033 NSC119875 approved resistant High Ehrlich Ascites Tumor cell line (EHR2,P6, P12, P36, P72, EHR2/1.3)
hsa-miR-210-3p Doxorubicin 31703 NSC123127 approved resistant High Ehrlich Ascites Tumor cell line (EHR2,P6, P12, P36, P72, EHR2/1.3)
hsa-miR-210-3p Trastuzumab resistant Low Breast Cancer tissue and cell line (BT-474, BTR65)
hsa-miR-210-3p Cisplatin 5460033 NSC119875 approved sensitive High Gastric Cancer cell line (SGC7901)
hsa-miR-210-3p Vincristine 5978 approved sensitive High Gastric Cancer cell line (SGC7901)
hsa-miR-210-3p Doxorubicin 31703 NSC123127 approved sensitive High Gastric Cancer cell line (SGC7901)
hsa-miR-210-3p Fluorouracil 3385 NSC19893 approved sensitive High Gastric Cancer cell line (SGC7901)
hsa-miR-210-3p Paclitaxel 36314 NSC125973 approved resistant Low Cervical Cancer tissue and cell line (SiHa, Cask)
hsa-miR-210-3p Paclitaxel 36314 NSC125973 approved resistant High Laryngeal Cancer cell line (Hep2)
hsa-miR-210-3p Fluorouracil + Oxaliplatin resistant High Colorectal Cancer tissue
hsa-miR-210-3p Docetaxel 148124 NSC628503 approved resistant High Prostate Cancer cell line (DU-145)
hsa-miR-210-3p Asparaginate 5460875 sensitive Low Pediatric Acute Lymphoblastic Leukemia Reh cells
hsa-miR-210-3p Dexamethasone 5743 NSC34521 approved sensitive Low Pediatric Acute Lymphoblastic Leukemia Reh cells
hsa-miR-210-3p Daunorubicin 30323 NSC82151 approved sensitive Low Pediatric Acute Lymphoblastic Leukemia Reh cells
hsa-miR-210-3p Gemcitabine 60750 NSC613327 approved resistant High Pancreatic Cancer cell line (PANC-1)
hsa-miR-210-3p Fluorouracil 3385 NSC19893 approved resistant High Pancreatic Cancer cell line (PANC-1)
hsa-miR-210-3p Fluorouracil 3385 NSC19893 approved sensitive High Esophageal Adenocarcinoma cell line (OE19)
hsa-miR-210-3p Doxorubicin 31703 NSC123127 approved resistant High Hepatocellular Carcinoma tissue and cell line (HepG2)
hsa-miR-210-3p Gemcitabine 60750 NSC613327 approved sensitive High Pancreatic Cancer cell line (SW1990)
hsa-miR-210-3p Gemcitabine 60750 NSC613327 approved resistant High Pancreatic Cancer cell line (SW1990)
hsa-miR-210-3p Taxane 9548828 sensitive High Prostate Cancer cell line (PC-3, PR20)
hsa-miR-210-3p Taxane 9548828 sensitive High Prostate Cancer cell line (PC-3, PR70)
hsa-miR-210-3p Dexamethasone 5743 NSC34521 approved sensitive High Myeloma cell line (MM1R, MM1S)
hsa-miR-210-3p Platinum 23939 sensitive High Ovarian Cancer tissue
hsa-miR-210-3p Daunorubicin 30323 NSC82151 approved sensitive High Acute Myeloid Leukemia cell line (U-937, KG-1)
hsa-miR-210-3p Gemcitabine 60750 NSC613327 approved resistant Low Pancreatic Ductal Adenocarcinoma cell line (MIA-PaCa-2)
hsa-miR-210-3p Trametinib 11707110 NSC758246 approved sensitive Low Melanoma cell line (MML-1)
hsa-miR-210-3p Paclitaxel 36314 NSC125973 approved resistant High Ovarian Cancer cell line (SKOV3)
hsa-miR-210-3p Tamoxifen 2733525 NSC180973 approved resistant Low Breast Cancer cell line (TAMR4, TAMR8)
hsa-miR-210-3p Aromatase Inhibitor sensitive Low Breast Cancer cell line (MCF-7)
hsa-miR-210-3p Epirubicin 41867 NSC256942 approved resistant High Breast Cancer cell line (MDA-MB-231)
hsa-miR-210-3p Docetaxel 148124 NSC628503 approved resistant High Breast Cancer cell line (MDA-MB-231)
hsa-miR-210-3p Vinorelbine 44424639 approved resistant High Breast Cancer cell line (MDA-MB-231)
hsa-miR-210-3p 1'-Acetoxychavicol acetate 119104 NSC711510 resistant Low Cervical Cancer cell line (Ca Ski, SiHa)
hsa-miR-210-3p Dabrafenib 44462760 NSC764134 approved sensitive High Melanoma cell line (A375, IGR37, 501Mel)
hsa-miR-210-3p Vemurafenib 42611257 NSC761431 approved sensitive High Melanoma cell line (A375, IGR37, 501Mel)
hsa-miR-210-3p Paclitaxel 36314 NSC125973 approved sensitive High Non-Small Cell Lung Cancer cell line (A549)
hsa-miR-210-3p Imatinib 5291 NSC743414 approved sensitive High Chronic Myelogenous Leukemia cell line (K562)
hsa-miR-210-3p Doxorubicin 31703 NSC123127 approved sensitive Low Renal Cell Cancer cell line (Caki-2)
hsa-miR-210-3p Vinblastine 442111 NSC90636 approved sensitive Low Renal Cell Cancer cell line (Caki-2)
hsa-miR-210-3p Fulvestrant 17756771 NSC719276 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-210-3p Ceritinib 57379345 NSC776422 approved resistant High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-miR-210-3p Methotrexate 126941 NSC740 approved resistant High Colorectal Cancer cell line (LS174T)
hsa-miR-210-3p Gemcitabine 60750 NSC613327 approved resistant Low Cholangiocarcinoma cell line (KKU-213, KKU-055, KKU-100)
hsa-miR-210-3p Docetaxel 148124 NSC628503 approved resistant Low Breast Cancer tissue
hsa-miR-210-3p Palbociclib 5330286 NSC758247 approved sensitive High Breast Cancer cell line (T47D)
hsa-miR-210-3p Paclitaxel 36314 NSC125973 approved sensitive High Ovarian Cancer cell line (SKOV3)
hsa-miR-210-3p Cisplatin 5460033 NSC119875 approved sensitive Low Ovarian Cancer cell line (SKOV3)
hsa-miR-210-3p Cetuximab + Folfox(Fluorouracil + Leucovorin + Oxaliplatin) sensitive High Metastatic Colorectal Cancer tissue
hsa-miR-210-3p Fluorouracil 3385 NSC19893 approved sensitive Low Colorectal Cancer cell line (HT-29)
hsa-miR-210-3p Gemcitabine 60750 NSC613327 approved resistant Low Pancreatic Cancer cell line (BXPC-3)
hsa-miR-210-3p Methotrexate 126941 NSC740 approved resistant High Colorectal Adenocarcinoma cell line (HT-29)
hsa-miR-210-3p Gemcitabine 60750 NSC613327 approved resistant Low Pancreatic Cancer cell line (PANC-1)
hsa-miR-210-3p Cisplatin 5460033 NSC119875 approved resistant Low Oral Cancer cell line (SAS, HSC-3, HSC-4)
hsa-miR-210-3p Paclitaxel 36314 NSC125973 approved sensitive High Endometrial Serous Carcinoma cell line (USPC1)
hsa-miR-210-3p Imatinib 5291 NSC743414 approved sensitive Low Chronic Myelogenous Leukemia tissue
hsa-miR-210-3p Dabrafenib 44462760 NSC764134 approved resistant High Melanoma cell line (A375)
hsa-miR-210-3p Sunitinib 5329102 NSC750690 approved resistant Low Renal Cell Cancer tissue
hsa-miR-210-3p Temozolomide 5394 NSC362856 approved resistant Low Glioma cell line (U87)
hsa-miR-210-3p Cisplatin 5460033 NSC119875 approved sensitive High Hypopharyngeal Cancer cell line (FaDu)
hsa-miR-210-3p Platinum 23939 resistant High High-Grade Serous Ovarian Cancer tissue
hsa-miR-210-3p Cisplatin 5460033 NSC119875 approved sensitive Low Breast Cancer cell line (MCF-7)
hsa-miR-210-3p Sorafenib 216239 NSC747971 approved resistant High Hepatocellular Carcinoma cell line (PLC/PRF5-R1, PLC/PRF5-R2, PLC/PRF5)
hsa-miR-210-3p Gefitinib 123631 NSC715055 approved sensitive cell line (HCC827)
hsa-miR-210-3p Vemurafenib 42611257 NSC761431 approved sensitive cell line (A375)
hsa-miR-210-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (CAL-27) (total RNA)
hsa-miR-210-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (CAL-27) (mitochondrial RNA)
hsa-miR-210-3p Vemurafenib 42611257 NSC761431 approved sensitive cell line (451Lu)
hsa-miR-210-3p Cisplatin 5460033 NSC119875 approved resistant cell line
hsa-miR-210-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-210-3p Paclitaxel 36314 NSC125973 approved resistant cell line (SKVO3ip1)
hsa-miR-210-3p Paclitaxel 36314 NSC125973 approved sensitive cell line (HeyA8)
hsa-miR-210-3p Vemurafenib 42611257 NSC761431 approved sensitive cell line (LM17)
hsa-miR-210-3p Vemurafenib 42611257 NSC761431 approved resistant cell line (LM16)
hsa-miR-210-3p Vemurafenib 42611257 NSC761431 approved sensitive cell line (LM11)
hsa-miR-210-3p Vemurafenib 42611257 NSC761431 approved resistant cell line (LM43)
hsa-miR-210-3p Vemurafenib 42611257 NSC761431 approved resistant cell line (LM47)
hsa-miR-210-3p Doxorubicin 31703 NSC123127 approved sensitive cell line (HS578T)
hsa-miR-210-3p Doxorubicin 31703 NSC123127 approved resistant cell line (BAS)
hsa-miR-210-3p Tamoxifen+Fulvestrant sensitive cell line (LCC9)
hsa-miR-210-3p Cisplatin 5460033 NSC119875 approved resistant cell line (CIS)
hsa-miR-210-3p Exemestane 60198 NSC713563 approved resistant cell line (MCF-7)
hsa-miR-210-3p Testosterone 6013 NSC9700 approved resistant cell line (MCF-7)
hsa-miR-210-3p Testosterone+Exemestane resistant cell line (MCF-7)
hsa-miR-210-3p Testosterone+Letrozole resistant cell line (MCF-7)
hsa-miR-210-3p Testosterone+Anastrozole resistant cell line (MCF-7)
hsa-miR-210-3p Testosterone+Tamoxifen resistant cell line (MCF-7)
hsa-miR-210-3p Osimertinib 71496458 NSC779217 approved sensitive cell line (H1975)
hsa-miR-210-3p Methotrexate 126941 NSC740 approved resistant cell line (HT29)
hsa-miR-210-3p Fluorouracil 3385 NSC19893 approved resistant cell line (KM12C) (72 h)
hsa-miR-210-3p Cisplatin 5460033 NSC119875 approved resistant cell line (RPMI2650)
hsa-miR-210-3p Sunitinib 5329102 NSC750690 approved resistant tissue (CardA)
hsa-miR-210-3p Paclitaxel 36314 NSC125973 approved resistant cell line (SKOV3)
hsa-miR-210-3p Platinum 23939 resistant tissue (non-small cell lung cancer)
hsa-miR-210-3p Tamoxifen 2733525 NSC180973 approved resistant cell line (TamR4)
hsa-miR-210-3p Tamoxifen 2733525 NSC180973 approved resistant cell line (TamR8)
hsa-miR-210-3p Paclitaxel 36314 NSC125973 approved sensitive cell line (PC3PR20)
hsa-miR-210-3p Paclitaxel 36314 NSC125973 approved sensitive cell line (PC3PR200)
hsa-miR-210-3p Paclitaxel 36314 NSC125973 approved sensitive cell line (PC3PR70)
hsa-miR-210-3p Vemurafenib 42611257 NSC761431 approved resistant cell line (LM16)
hsa-miR-210-3p Bortezomib 387447 NSC681239 approved sensitive cell line (CCRF-CEM) (100 nM)
hsa-miR-210-3p Bortezomib 387447 NSC681239 approved sensitive cell line (CCRF-CEM) (200 nM)
hsa-miR-210-3p Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (100 ng/ml)
hsa-miR-210-3p Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (1500 ng/ml)
hsa-miR-210-3p Gemcitabine 60750 NSC613327 approved sensitive cell line (Panc1-GR1)
hsa-miR-210-3p Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)
hsa-miR-210-3p Cisplatin 5460033 NSC119875 approved resistant cell line (H23)
hsa-miR-210-3p Cetuximab sensitive tissue (colorectal carcinoma)

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