miRTarBase - #MIRT054483


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pre-miRNA Information
pre-miRNA hsa-mir-488   
Genomic Coordinates chr1: 177029363 - 177029445
Synonyms MIRN488, hsa-mir-488, MIR488
Description Homo sapiens miR-488 stem-loop
Comment miR-488-3p cloned in has a 1 nt 3' extension (U), which is incompatible with the genome sequence.
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-488-3p
Sequence 52| UUGAAAGGCUAUUUCUUGGUC |72
Evidence Experimental
Experiments Cloned
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 5 1 - 177029390 27229138, 28550310, 29165639, 29233923 MiREDiBase
A-to-I 6 1 - 177029389 29233923 MiREDiBase
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSN1079766 12 COSMIC
COSN19660590 16 COSMIC
COSN30190142 18 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1210074726 7 dbSNP
rs1310911055 17 dbSNP
rs1248997320 19 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol SLC39A8   
Synonyms BIGM103, CDG2N, LZT-Hs6, PP3105, ZIP8
Description solute carrier family 39 member 8
Transcript NM_001135147   
Other Transcripts NM_001135146 , NM_001135148 , NM_022154   
Expression
Putative miRNA Targets on SLC39A8
3'UTR of SLC39A8
(miRNA target sites are highlighted)		 
>SLC39A8|NM_001135147|3'UTR
   1 TAATTTCATTATCTGGAGTATTTCACCTCCACATCTCTGCAATACCAGCACCTTCAACAGTGATTGGTTAGAGGTTGGCA
  81 TATGACATAGTTATGACCATTGAGACGTGATGCTGTGTGTGCTGTGAAGTTTCTCAAAAGGAGTAAGGAAGATACAGCCT
 161 CTTCTTTCTAGGGACTTTGTTTGTAGGTGTGACACCTGGAGCAGCCATTTTGCTACTGTTTTGTTTCTAATTGTGTTCCC
 241 CGCCGCCCTCCCCGCTCGCCCCGAAAAACGACATGTTTGAGTTCTAATCCCCAGTATTTCAGAATGTGACCTTATTTGGA
 321 AATAGAGTCATTGCAAATGTAATTTGTTAAGATGAGCTCATACTGGAGTAGAGTGGGTTCCTGATCTAGTATGACTGGTA
 401 TTCTTATTAAAAAGAGAAATTTGAATACTAGCTACACCATGTAAAGATGAAGGCAGAGATCGTGGTGATGCATCTACAAT
 481 GTCAACAATTGCCAGCAAATCATCAGAATCTGGGAGAGAGGTATGGAATGAATTCTCTCTCGCAGCCCTAAGAAGGAACC
 561 AATCCTGTGCACACCTGAATCTTGGACTTCCAGCCTCCACAACTGTGAGACAATACATTTTTGTTATTTAAGCTACCCAG
 641 TTGTGGCACTTTATTACTGCAGTTCTAGCCGACTAATACAGCTACCTTGAGAGGAAATAGCATGGGGATGAAGGTGATGT
 721 GCTGAAGAAGCACAGCAGAAAGTGGAAAGATGGTCCATGAGGACATCCTTAGCCACTGAATTGACAAGCCTCTTCCCTGG
 801 AGTCCCTCTTCCTTGGGATTTTTTTTGGTGTGTGTAATAATCACTTTTCCTAATGGTGCAAACCATTGTGAGTTGCTCTT
 881 TGACTGCTAGTAATTAAAGCAAACTAACCAAGTCAGCCCTCCCCAGTGTTCCTTTTTGCAATCTAAATTCTGATGTCCAA
 961 CTCCTCCCTGGGCCACTCCCTGTCCCCAGATGTCTCTTTGTATATCTAAAGAAGAAAAAGAAGGATAAATCCTTTTTCTC
1041 CCAAGAGATCTCCCTGCTTTTGTGAAAAGCACAAAGAAGGGCATTATCTAACTTTTCTCATCATTAGAAGTCAAGCCTGG
1121 CCGTGACTCCCGTTATGACATTTTGATGGCCACATTTTATGAGAAAAGCCCAAACAGACAGACCTGTCTGTAAATTCTTT
1201 CATCCTTTGCATTCTTTCTTTGACTGTACCTTAGAGAGTGTTTGATTATTGCAGGGGAGATGGAAAAGAAGCAGGTTCTG
1281 GCCTATGCTCTAGTTCCTCACTTTCTGGAGTTATCTTTTGGGCCTGGAGTCTCTTGGAGTGAGGAAAGGAAGCCATTTTT
1361 ATACTTTACTTATGGTAGAGTTAAACTTCGTACTCTTAGGAGGCTACATGCAATCTCCAAGAGGAAGAGAGTGAAGAGGT
1441 TAAGAATTATGCCATCAAAATGTGCTGCTCTGGCATATTGACTATTTGAATTACAGATATTTTAAAAACATCAGATATGA
1521 AGAGGTCACTCTGATCTTAATTCTGTGTCTTAACAGCAGGAGATGAAATTCCCACATGGGAGATGGCCTCCCTGTCACAG
1601 AAGGAATACCATTCTCCCTATCAATGATGAGAAATTGGAACTGAGAGAATTCTGTATAGACCTTGTTCAAGTAATTCTTC
1681 TATTTTAAACCTCCCCACATAATTTAGCTGCCTTTTCAAAACTACTGTCCTTTGTGCAACCAGTATAGAAGCGATTGACT
1761 CTCACTGCATCCTTGGGTCTTCTTTTCCCTATATGGGCTCTTTTCCCATATGGGCTCTTATGTCCTGTAAAACATGTATT
1841 AAATAAATTTGTATGCTTTTCTCCCGTTAACCTGTCTTACATCAATTTAATTCTTGGGCCCAGGTAGGACCCTAAGAGGA
1921 CAGAGGTCGAGTTTTGCCACCTCTGCAAGAGAAAAGAGAGATGCCCAGACCACCAGGCCTGGGAAATCTTTGATTTCCCA
2001 GGCTTTGAAGTGGGCACTGTGTCTGAACCTGGCCCTCTGAAACTTCCTGTTCCTGGACATCCCAGCTGCTAATGTGAGTT
2081 GCCCTTGCACTGGCTCAGGGCTGGGACATTAAAGGAATTTCCCTTTTGTTGACATAACAGTAGGATGGCTATAGCTAACA
2161 ATAATATATTATTTAGTTTCAAGTAGCTAGAAGGAACATATGAATGTTCCCAACACAAAGAAATGACAACTATTTGAGAT
2241 GATGGATATGCTAATAACCTTAATCTGATTCCTATACATTATATGCATCACATATACATACATTATATGTATAACATCAC
2321 TATGTACCCCATAAATATGTGCAATTATTGTCAATTAAACAAATAAATTTAAACAAACATTAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' cuGGU-UCUU-UAUC----GGAAAGUu 5'
            ||| | ||  |||    |:||||| 
Target 5' ccCCACATAATTTAGCTGCCTTTTCAa 3'
 1693 - 1719 133.00 -7.90
2 
miRNA  3' cuggUUCUUUAUCGGAAAGUu 5'
              |:||| |  |||||:: 
Target 5' ttaaAGGAATTTCCCTTTTGt 3'
 2109 - 2129 125.00 -8.30
3 
miRNA  3' cugGUUCUUUAUC----GGAAAGUu 5'
             :::||:||:|    ||| ||| 
Target 5' acaTGGGAGATGGCCTCCCTGTCAc 3'
 1574 - 1598 124.00 -13.70
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30166319 35 COSMIC
COSN31479993 37 COSMIC
COSN30122586 51 COSMIC
COSN30135621 85 COSMIC
COSN19660885 88 COSMIC
COSN30111979 148 COSMIC
COSN30167499 151 COSMIC
COSN31581780 193 COSMIC
COSN32063515 258 COSMIC
COSN5006934 364 COSMIC
COSN16058372 1112 COSMIC
COSN8931356 1151 COSMIC
COSN1976956 1221 COSMIC
COSN23703086 1337 COSMIC
COSN6788087 1428 COSMIC
COSN27957648 2010 COSMIC
COSN15745357 2130 COSMIC
COSN7721387 2294 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs571222157 1 dbSNP
rs894769983 2 dbSNP
rs546748336 8 dbSNP
rs1212757539 11 dbSNP
rs749899476 12 dbSNP
rs1285033813 14 dbSNP
rs767038837 15 dbSNP
rs373054136 24 dbSNP
rs1457352880 26 dbSNP
rs1318320568 31 dbSNP
rs917960793 32 dbSNP
rs375553435 37 dbSNP
rs114824667 43 dbSNP
rs1276972945 49 dbSNP
rs1193586119 59 dbSNP
rs561395873 71 dbSNP
rs1220028398 73 dbSNP
rs138590198 76 dbSNP
rs962873135 81 dbSNP
rs1182614476 84 dbSNP
rs1243325083 85 dbSNP
rs1267735717 86 dbSNP
rs1488872173 87 dbSNP
rs151370 88 dbSNP
rs947505304 90 dbSNP
rs116469245 94 dbSNP
rs545701583 103 dbSNP
rs1051484251 104 dbSNP
rs1420030766 105 dbSNP
rs931802711 106 dbSNP
rs923219452 107 dbSNP
rs1370151482 113 dbSNP
rs1472750060 115 dbSNP
rs1425168364 135 dbSNP
rs578241619 138 dbSNP
rs559797877 150 dbSNP
rs73836548 154 dbSNP
rs750963273 159 dbSNP
rs1298419014 167 dbSNP
rs1378964455 169 dbSNP
rs1442322352 172 dbSNP
rs1394623871 173 dbSNP
rs1315228772 176 dbSNP
rs925169680 179 dbSNP
rs1334594525 185 dbSNP
rs1283983890 193 dbSNP
rs984835550 202 dbSNP
rs951838306 204 dbSNP
rs1237084401 206 dbSNP
rs1482375451 209 dbSNP
rs1023338108 215 dbSNP
rs1257939868 216 dbSNP
rs1445170566 218 dbSNP
rs1013072283 222 dbSNP
rs373502845 224 dbSNP
rs894632877 226 dbSNP
rs1420964285 231 dbSNP
rs1416194255 236 dbSNP
rs780285466 241 dbSNP
rs574191900 242 dbSNP
rs1445297938 243 dbSNP
rs1433478939 244 dbSNP
rs554644233 245 dbSNP
rs1446787079 248 dbSNP
rs1307673912 252 dbSNP
rs535966969 253 dbSNP
rs974324257 254 dbSNP
rs11463671 258 dbSNP
rs35608353 258 dbSNP
rs374483815 259 dbSNP
rs1231197532 262 dbSNP
rs11382393 263 dbSNP
rs1236255485 263 dbSNP
rs397697625 263 dbSNP
rs1015801518 265 dbSNP
rs1189934636 268 dbSNP
rs1177790967 269 dbSNP
rs1412409197 269 dbSNP
rs151371 270 dbSNP
rs1258041426 271 dbSNP
rs1209869643 272 dbSNP
rs1403109712 274 dbSNP
rs1345395884 275 dbSNP
rs1274340691 284 dbSNP
rs1286272321 289 dbSNP
rs538271382 290 dbSNP
rs1221211270 301 dbSNP
rs1224237702 310 dbSNP
rs1302219055 316 dbSNP
rs1349363036 326 dbSNP
rs1324054032 327 dbSNP
rs571474206 330 dbSNP
rs1277246074 356 dbSNP
rs371827144 359 dbSNP
rs1234794220 362 dbSNP
rs183898347 363 dbSNP
rs893262192 368 dbSNP
rs746153655 371 dbSNP
rs1476750433 373 dbSNP
rs1347278554 374 dbSNP
rs1192603112 376 dbSNP
rs1429589889 377 dbSNP
rs931833616 379 dbSNP
rs1477261253 382 dbSNP
rs151372 383 dbSNP
rs975890824 391 dbSNP
rs1411081417 400 dbSNP
rs940632862 416 dbSNP
rs1348259508 420 dbSNP
rs1400612335 427 dbSNP
rs1405932411 432 dbSNP
rs549476462 437 dbSNP
rs1167185121 440 dbSNP
rs373243352 441 dbSNP
rs984476335 453 dbSNP
rs375312544 458 dbSNP
rs1319735177 461 dbSNP
rs58321370 462 dbSNP
rs1289038827 469 dbSNP
rs1000820132 472 dbSNP
rs1185999889 488 dbSNP
rs1023369342 494 dbSNP
rs192230775 496 dbSNP
rs533373084 497 dbSNP
rs960419701 498 dbSNP
rs896294504 499 dbSNP
rs1446326162 503 dbSNP
rs764338619 508 dbSNP
rs559986721 514 dbSNP
rs1426306090 515 dbSNP
rs1475933069 517 dbSNP
rs1163230211 521 dbSNP
rs541407500 522 dbSNP
rs1407530151 523 dbSNP
rs1164312151 534 dbSNP
rs1234579956 535 dbSNP
rs1359909492 541 dbSNP
rs1334857865 542 dbSNP
rs554500390 543 dbSNP
rs926658586 545 dbSNP
rs1231022055 546 dbSNP
rs1364583436 550 dbSNP
rs1271103819 559 dbSNP
rs138281725 560 dbSNP
rs190178 564 dbSNP
rs1011613416 579 dbSNP
rs893130862 583 dbSNP
rs1050525132 584 dbSNP
rs754873710 586 dbSNP
rs996281396 590 dbSNP
rs901900966 591 dbSNP
rs867667881 600 dbSNP
rs188436242 605 dbSNP
rs574964656 607 dbSNP
rs1393783256 610 dbSNP
rs1163084339 611 dbSNP
rs1474065968 613 dbSNP
rs1164755418 614 dbSNP
rs556643467 615 dbSNP
rs1430501676 632 dbSNP
rs538208254 641 dbSNP
rs1417902224 652 dbSNP
rs147043927 670 dbSNP
rs1385992466 673 dbSNP
rs1049438407 678 dbSNP
rs72924805 679 dbSNP
rs1338474386 680 dbSNP
rs1454579658 691 dbSNP
rs1315610354 693 dbSNP
rs964450218 698 dbSNP
rs534640178 702 dbSNP
rs1437178742 713 dbSNP
rs1246131214 724 dbSNP
rs1199468100 728 dbSNP
rs1277017594 737 dbSNP
rs1462929786 739 dbSNP
rs1215415414 742 dbSNP
rs567440217 745 dbSNP
rs769595661 746 dbSNP
rs1438345552 753 dbSNP
rs747930882 754 dbSNP
rs1211481434 758 dbSNP
rs1477858038 759 dbSNP
rs1171034980 767 dbSNP
rs1399850474 770 dbSNP
rs960450592 784 dbSNP
rs1337093382 785 dbSNP
rs1274215984 787 dbSNP
rs372702711 788 dbSNP
rs1360223372 794 dbSNP
rs981671146 799 dbSNP
rs1308533012 802 dbSNP
rs1335816101 802 dbSNP
rs1232159425 813 dbSNP
rs967944083 818 dbSNP
rs1272681878 824 dbSNP
rs1411074253 827 dbSNP
rs903487505 827 dbSNP
rs1442225847 828 dbSNP
rs13126885 830 dbSNP
rs1012225860 831 dbSNP
rs1198064933 841 dbSNP
rs1251422375 853 dbSNP
rs768293212 861 dbSNP
rs439757 868 dbSNP
rs1355325904 870 dbSNP
rs1480863353 878 dbSNP
rs550059908 884 dbSNP
rs1176890495 889 dbSNP
rs1422580395 893 dbSNP
rs1169937637 895 dbSNP
rs1056217871 906 dbSNP
rs901930710 907 dbSNP
rs757954642 918 dbSNP
rs183555291 924 dbSNP
rs438803 925 dbSNP
rs1347016939 926 dbSNP
rs1223689474 927 dbSNP
rs905288131 928 dbSNP
rs1316445597 936 dbSNP
rs1230312543 937 dbSNP
rs533357902 942 dbSNP
rs1038382481 943 dbSNP
rs1004748164 955 dbSNP
rs1454634520 957 dbSNP
rs1271059060 960 dbSNP
rs779513929 961 dbSNP
rs886253552 966 dbSNP
rs1048862420 967 dbSNP
rs757595110 968 dbSNP
rs1426484176 974 dbSNP
rs1172503869 975 dbSNP
rs565966444 976 dbSNP
rs1457305281 977 dbSNP
rs916462451 979 dbSNP
rs548051626 985 dbSNP
rs922800832 988 dbSNP
rs1297170511 989 dbSNP
rs975578185 993 dbSNP
rs1384299772 998 dbSNP
rs1296688241 999 dbSNP
rs1321648197 1002 dbSNP
rs444943 1015 dbSNP
rs927771539 1026 dbSNP
rs764237060 1028 dbSNP
rs761024015 1032 dbSNP
rs1347789291 1035 dbSNP
rs1261273155 1036 dbSNP
rs867868612 1062 dbSNP
rs1301415243 1078 dbSNP
rs1188078095 1084 dbSNP
rs913411035 1088 dbSNP
rs1374065541 1099 dbSNP
rs1020603505 1100 dbSNP
rs1440262299 1115 dbSNP
rs1424719740 1119 dbSNP
rs141644183 1122 dbSNP
rs1175275060 1123 dbSNP
rs1009931890 1131 dbSNP
rs768988816 1132 dbSNP
rs1029211270 1140 dbSNP
rs1317736937 1146 dbSNP
rs1394414558 1150 dbSNP
rs370466294 1151 dbSNP
rs147913943 1154 dbSNP
rs1034860646 1157 dbSNP
rs1283917830 1161 dbSNP
rs372946392 1172 dbSNP
rs774593442 1176 dbSNP
rs1250551273 1186 dbSNP
rs1261164997 1195 dbSNP
rs1482789112 1201 dbSNP
rs1201750291 1214 dbSNP
rs1019051373 1223 dbSNP
rs1005395648 1225 dbSNP
rs1445127811 1227 dbSNP
rs886496501 1240 dbSNP
rs1176320942 1251 dbSNP
rs1481852421 1253 dbSNP
rs1027907140 1256 dbSNP
rs1260140605 1259 dbSNP
rs1405092645 1261 dbSNP
rs1212028112 1263 dbSNP
rs994587929 1275 dbSNP
rs1159370523 1283 dbSNP
rs1358988013 1284 dbSNP
rs1485517312 1286 dbSNP
rs1339047664 1295 dbSNP
rs1407508169 1295 dbSNP
rs1446606406 1298 dbSNP
rs1307251590 1301 dbSNP
rs1375621312 1301 dbSNP
rs1254771017 1302 dbSNP
rs1224585217 1303 dbSNP
rs895104111 1315 dbSNP
rs1054956953 1323 dbSNP
rs1310615485 1323 dbSNP
rs193097630 1337 dbSNP
rs1222346835 1350 dbSNP
rs1264701587 1352 dbSNP
rs1461722928 1362 dbSNP
rs1357590644 1370 dbSNP
rs887137268 1372 dbSNP
rs1047050770 1373 dbSNP
rs752883104 1389 dbSNP
rs549277702 1390 dbSNP
rs1179030831 1400 dbSNP
rs79162237 1402 dbSNP
rs463373 1406 dbSNP
rs914963346 1413 dbSNP
rs1327408009 1417 dbSNP
rs1356405102 1429 dbSNP
rs1443054259 1435 dbSNP
rs942861861 1442 dbSNP
rs577545227 1445 dbSNP
rs552729226 1458 dbSNP
rs541037692 1462 dbSNP
rs936152470 1463 dbSNP
rs573827731 1465 dbSNP
rs1285022867 1467 dbSNP
rs773161746 1478 dbSNP
rs1217977314 1483 dbSNP
rs1309130671 1484 dbSNP
rs1204640726 1501 dbSNP
rs974972567 1512 dbSNP
rs966259909 1517 dbSNP
rs460026 1521 dbSNP
rs1201134649 1522 dbSNP
rs1270107429 1528 dbSNP
rs761525241 1543 dbSNP
rs1477688685 1551 dbSNP
rs913595896 1556 dbSNP
rs1422314382 1563 dbSNP
rs1485567858 1573 dbSNP
rs1410955532 1576 dbSNP
rs537232321 1585 dbSNP
rs1027733975 1586 dbSNP
rs994661586 1594 dbSNP
rs894967926 1596 dbSNP
rs1033581663 1597 dbSNP
rs76076966 1618 dbSNP
rs1034911748 1619 dbSNP
rs1161506188 1623 dbSNP
rs144729460 1624 dbSNP
rs1002051880 1628 dbSNP
rs1268153554 1631 dbSNP
rs969216901 1635 dbSNP
rs1016754849 1637 dbSNP
rs1288594922 1646 dbSNP
rs1356606804 1649 dbSNP
rs906424079 1653 dbSNP
rs1191494725 1654 dbSNP
rs1244139923 1656 dbSNP
rs1042455986 1678 dbSNP
rs1181788587 1682 dbSNP
rs945023016 1682 dbSNP
rs768334679 1696 dbSNP
rs1164239640 1703 dbSNP
rs1360163692 1706 dbSNP
rs551944051 1708 dbSNP
rs1399105341 1721 dbSNP
rs887196899 1736 dbSNP
rs149178973 1740 dbSNP
rs1053526382 1752 dbSNP
rs62327889 1753 dbSNP
rs1380430820 1755 dbSNP
rs1247578648 1758 dbSNP
rs1294167310 1759 dbSNP
rs1315058542 1761 dbSNP
rs547444978 1763 dbSNP
rs1349523326 1766 dbSNP
rs1202990424 1767 dbSNP
rs922112585 1768 dbSNP
rs1339704207 1777 dbSNP
rs1310278387 1787 dbSNP
rs1383921630 1793 dbSNP
rs1040000301 1796 dbSNP
rs150578207 1798 dbSNP
rs974879322 1805 dbSNP
rs926141611 1806 dbSNP
rs1455194010 1816 dbSNP
rs1468848272 1817 dbSNP
rs1160505013 1818 dbSNP
rs1386932841 1820 dbSNP
rs944960552 1822 dbSNP
rs1165223776 1834 dbSNP
rs1335798795 1836 dbSNP
rs1403827110 1850 dbSNP
rs1474657856 1851 dbSNP
rs1454455068 1853 dbSNP
rs946166307 1855 dbSNP
rs1334658968 1857 dbSNP
rs779835093 1863 dbSNP
rs1367154801 1864 dbSNP
rs145362997 1865 dbSNP
rs568375194 1866 dbSNP
rs550102915 1868 dbSNP
rs973442981 1872 dbSNP
rs1463056677 1876 dbSNP
rs959426845 1880 dbSNP
rs868823972 1885 dbSNP
rs1436134914 1887 dbSNP
rs927614950 1892 dbSNP
rs1364635405 1893 dbSNP
rs1477786088 1896 dbSNP
rs1175460974 1898 dbSNP
rs1273862804 1899 dbSNP
rs980684980 1904 dbSNP
rs1337278104 1914 dbSNP
rs1395205127 1921 dbSNP
rs1389199505 1925 dbSNP
rs779568914 1926 dbSNP
rs1003298802 1928 dbSNP
rs971054640 1929 dbSNP
rs531788316 1936 dbSNP
rs75877188 1940 dbSNP
rs1251268696 1946 dbSNP
rs893461176 1947 dbSNP
rs1337974303 1961 dbSNP
rs1053425624 1968 dbSNP
rs545072433 1969 dbSNP
rs1326738477 1976 dbSNP
rs1025741831 1977 dbSNP
rs996610725 1978 dbSNP
rs781384740 1981 dbSNP
rs1251266727 1987 dbSNP
rs1490264722 1989 dbSNP
rs1197533416 1990 dbSNP
rs1266561468 1991 dbSNP
rs1481283598 1996 dbSNP
rs998248964 1997 dbSNP
rs1372462369 1999 dbSNP
rs1460342445 2003 dbSNP
rs1169155608 2004 dbSNP
rs1296827997 2006 dbSNP
rs150052063 2011 dbSNP
rs1018277675 2012 dbSNP
rs1325987078 2026 dbSNP
rs1300866190 2029 dbSNP
rs559422165 2035 dbSNP
rs540624685 2049 dbSNP
rs1039222069 2050 dbSNP
rs17032259 2057 dbSNP
rs912162378 2058 dbSNP
rs1047962235 2068 dbSNP
rs1252034593 2078 dbSNP
rs1358782250 2087 dbSNP
rs555695658 2094 dbSNP
rs904773987 2099 dbSNP
rs543766929 2103 dbSNP
rs1372813395 2128 dbSNP
rs1490562877 2134 dbSNP
rs1191560949 2135 dbSNP
rs946248483 2148 dbSNP
rs115725190 2149 dbSNP
rs1253783878 2154 dbSNP
rs973349752 2156 dbSNP
rs766423480 2158 dbSNP
rs1449883085 2159 dbSNP
rs1252933900 2162 dbSNP
rs866459705 2166 dbSNP
rs557947269 2167 dbSNP
rs959459035 2168 dbSNP
rs1288718627 2175 dbSNP
rs926670299 2180 dbSNP
rs113341965 2183 dbSNP
rs1383256329 2189 dbSNP
rs1196564101 2193 dbSNP
rs1384460396 2196 dbSNP
rs982393183 2197 dbSNP
rs1296896433 2217 dbSNP
rs539639189 2224 dbSNP
rs575062728 2226 dbSNP
rs1243907709 2232 dbSNP
rs752938066 2238 dbSNP
rs1360455204 2244 dbSNP
rs1009504076 2249 dbSNP
rs554251970 2250 dbSNP
rs939091393 2255 dbSNP
rs1032018774 2257 dbSNP
rs1489588625 2258 dbSNP
rs1443861149 2262 dbSNP
rs62327888 2268 dbSNP
rs755050258 2272 dbSNP
rs1040806407 2275 dbSNP
rs568165132 2283 dbSNP
rs1157877158 2285 dbSNP
rs1226177245 2286 dbSNP
rs376735312 2289 dbSNP
rs1455697487 2294 dbSNP
rs139427870 2296 dbSNP
rs890608957 2298 dbSNP
rs766352045 2303 dbSNP
rs1303992740 2305 dbSNP
rs1338848647 2309 dbSNP
rs929588498 2323 dbSNP
rs920815108 2324 dbSNP
rs1223466939 2331 dbSNP
rs1305101673 2331 dbSNP
rs1318904931 2332 dbSNP
rs909809490 2341 dbSNP
rs1328805207 2350 dbSNP
rs576220589 2354 dbSNP
rs1201690714 2355 dbSNP
rs1244488237 2359 dbSNP
rs539527521 2362 dbSNP
rs1330497021 2365 dbSNP
rs1037671074 2366 dbSNP
rs538181621 2369 dbSNP
rs1248020141 2371 dbSNP
rs80137092 2373 dbSNP
rs1167097913 2374 dbSNP
rs552468087 2375 dbSNP
rs465144 2378 dbSNP
rs559173792 2382 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions unspecified
Disease 64116.0
Location of target site 3'UTR
Tools used in this research unspecified
Original Description (Extracted from the article) ... "As seen in Figure 3D ...

- Song J; Kim D; Lee CH; Lee MS; Chun CH; Jin EJ, 2013, Journal of biomedical science.

Article - Song J; Kim D; Lee CH; Lee MS; Chun CH; Jin EJ
- Journal of biomedical science, 2013
BACKGROUND: Even though osteoarthritis (OA) is the most common musculoskeletal dysfunction, there are no effective pharmacological treatments to treat OA due to lack of understanding in OA pathology. To better understand the mechanism in OA pathogenesis and investigate its effective target, we analyzed miRNA profiles during OA pathogenesis and verify the role and its functional targets of miR-488. RESULTS: Human articular chondrocytes were obtained from cartilage of OA patients undergoing knee replacement surgery and biopsy samples of normal cartilage and the expression profile of miRNA was analyzed. From expression profile, most potent miR was selected and its target and functional role in OA pathogenesis were investigated using target validation system and OA animal model system. Among miRNAs tested, miR-488 was significantly decreased in OA chondrocytes Furthermore, we found that exposure of IL-1beta was also suppressed whereas exposure of TGF-beta3 induced the induction of miR-488 in human articular chondrocytes isolated from biopsy samples of normal cartilages. Target validation study showed that miR-488 targets ZIP8 and suppression of ZIP8 in OA animal model showed the reduced cartilage degradation. Target validation study showed that miR-488 targets ZIP8 and suppression of ZIP8 in OA animal model showed the reduced cartilage degradation. CONCLUSIONS: miR-488 acts as a positive role for chondrocyte differentiation/cartilage development by inhibiting MMP-13 activity through targeting ZIP-8.
LinkOut: [PMID: 23688035]
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE28544 Breast cancer -0.509 5.5e-3 -0.701 6.8e-5 24 Click to see details
GSE17498 Multiple myeloma -0.291 3.4e-2 -0.042 4.0e-1 40 Click to see details
GSE38974 Chronic obstructive pulmonary disease 0.37 3.4e-2 0.200 1.7e-1 25 Click to see details
GSE19350 CNS germ cell tumors 0.494 5.1e-2 0.441 7.6e-2 12 Click to see details
GSE32688 Pancreatic cancer 0.281 6.0e-2 0.172 1.7e-1 32 Click to see details
GSE21687 Ependynoma primary tumors -0.193 6.3e-2 -0.236 3.0e-2 64 Click to see details
GSE42095 Differentiated embryonic stem cells -0.302 8.1e-2 -0.200 1.8e-1 23 Click to see details
GSE38226 Liver fibrosis 0.292 1.0e-1 0.301 9.2e-2 21 Click to see details
GSE27834 Pluripotent stem cells 0.27 1.6e-1 0.265 1.6e-1 16 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis 0.194 2.1e-1 -0.233 1.6e-1 20 Click to see details
GSE21849 B cell lymphoma -0.137 2.4e-1 -0.096 3.1e-1 29 Click to see details
GSE17306 Multiple myeloma 0.085 2.8e-1 0.495 1.5e-4 49 Click to see details
GSE15076 Monocyte-derived dendritic cells 0.423 3.6e-1 0.500 3.3e-1 3 Click to see details
GSE26953 Aortic valvular endothelial cells -0.056 4.0e-1 -0.130 2.7e-1 24 Click to see details
GSE28260 Renal cortex and medulla 0.054 4.3e-1 0.018 4.8e-1 13 Click to see details
GSE28260 Renal cortex and medulla 0.054 4.3e-1 0.018 4.8e-1 13 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
THCA -0.975 0.01 -0.800 0.1 4 Click to see details
ESCA -0.974 0.07 -0.500 0.33 3 Click to see details
UCEC 0.304 0.17 0.273 0.2 12 Click to see details
PRAD -0.164 0.27 -0.118 0.33 16 Click to see details
KIRP 0.355 0.28 0.300 0.31 5 Click to see details
LIHC 0.126 0.38 0.143 0.37 8 Click to see details
BRCA 0.09 0.38 -0.033 0.46 13 Click to see details
PCPG 0.344 0.39 0.500 0.33 3 Click to see details
HNSC 0.121 0.41 -0.086 0.44 6 Click to see details
LUSC 0.029 0.48 0.086 0.44 6 Click to see details
LUSC 0.029 0.48 0.086 0.44 6 Click to see details
LUSC 0.029 0.48 0.086 0.44 6 Click to see details
LUSC 0.029 0.48 0.086 0.44 6 Click to see details
LUSC 0.029 0.48 0.086 0.44 6 Click to see details
LUSC 0.029 0.48 0.086 0.44 6 Click to see details
116 hsa-miR-488-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT005899 POMC proopiomelanocortin 3 1
MIRT038008 CYP2E1 cytochrome P450 family 2 subfamily E member 1 1 1
MIRT054483 SLC39A8 solute carrier family 39 member 8 2 1
MIRT058884 C11ORF58 chromosome 11 open reading frame 58 2 2
MIRT061194 MED17 mediator complex subunit 17 2 2
MIRT167237 TMEM167A transmembrane protein 167A 2 2
MIRT188343 ARID1A AT-rich interaction domain 1A 2 2
MIRT218170 MRPL18 mitochondrial ribosomal protein L18 2 2
MIRT218297 C6ORF120 chromosome 6 open reading frame 120 2 2
MIRT263337 ANAPC16 anaphase promoting complex subunit 16 2 2
MIRT294633 ZNF548 zinc finger protein 548 2 2
MIRT305053 SRPRB SRP receptor beta subunit 2 6
MIRT306846 FYTTD1 forty-two-three domain containing 1 2 2
MIRT442753 NRIP3 nuclear receptor interacting protein 3 2 2
MIRT443955 S1PR2 sphingosine-1-phosphate receptor 2 2 2
MIRT444032 SYNM synemin 2 2
MIRT444519 WWTR1 WW domain containing transcription regulator 1 2 2
MIRT444569 UNC5C unc-5 netrin receptor C 2 2
MIRT444779 ECE1 endothelin converting enzyme 1 2 2
MIRT445195 FAXC failed axon connections homolog 2 2
MIRT445345 FAM169A family with sequence similarity 169 member A 2 2
MIRT445539 TBC1D8 TBC1 domain family member 8 2 2
MIRT446058 RABIF RAB interacting factor 2 2
MIRT446358 EFCAB6 EF-hand calcium binding domain 6 2 2
MIRT446486 PRELP proline and arginine rich end leucine rich repeat protein 2 2
MIRT446973 CARKD NAD(P)HX dehydratase 2 2
MIRT446984 MOB1B MOB kinase activator 1B 2 2
MIRT446987 TMEM9B TMEM9 domain family member B 2 2
MIRT447376 AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5 2 2
MIRT447857 MLLT1 MLLT1, super elongation complex subunit 2 2
MIRT448077 BRMS1L breast cancer metastasis-suppressor 1 like 2 2
MIRT448970 CBX5 chromobox 5 2 2
MIRT449072 RPS15A ribosomal protein S15a 2 2
MIRT449200 PTPLAD2 3-hydroxyacyl-CoA dehydratase 4 1 1
MIRT449459 HAT1 histone acetyltransferase 1 2 2
MIRT449588 PCDHA6 protocadherin alpha 6 2 2
MIRT449885 ZNF621 zinc finger protein 621 2 2
MIRT449892 C11orf34 placenta expressed transcript 1 1 2
MIRT450669 SGIP1 SH3 domain GRB2 like endophilin interacting protein 1 2 2
MIRT450866 GPR107 G protein-coupled receptor 107 2 2
MIRT450881 EIF6 eukaryotic translation initiation factor 6 2 2
MIRT455373 AAED1 AhpC/TSA antioxidant enzyme domain containing 1 2 2
MIRT458266 FUT10 fucosyltransferase 10 2 2
MIRT464839 RPS27A ribosomal protein S27a 2 12
MIRT465335 TPM3 tropomyosin 3 2 4
MIRT467939 SLC16A1 solute carrier family 16 member 1 2 2
MIRT468719 SDC4 syndecan 4 2 2
MIRT469844 PXK PX domain containing serine/threonine kinase like 2 8
MIRT474545 KLHDC3 kelch domain containing 3 2 2
MIRT480700 BRPF1 bromodomain and PHD finger containing 1 2 2
MIRT482087 ALG8 ALG8, alpha-1,3-glucosyltransferase 2 2
MIRT491225 KCNA5 potassium voltage-gated channel subfamily A member 5 2 2
MIRT497790 DTX3L deltex E3 ubiquitin ligase 3L 2 2
MIRT497831 GPR26 G protein-coupled receptor 26 2 2
MIRT497910 HERC2 HECT and RLD domain containing E3 ubiquitin protein ligase 2 2 2
MIRT498428 DDX39A DExD-box helicase 39A 2 2
MIRT499196 TJAP1 tight junction associated protein 1 2 2
MIRT500396 ZNF281 zinc finger protein 281 2 6
MIRT501523 PPP1R15B protein phosphatase 1 regulatory subunit 15B 2 10
MIRT504445 MC2R melanocortin 2 receptor 2 2
MIRT505270 TUBB2A tubulin beta 2A class IIa 2 2
MIRT508584 CCDC115 coiled-coil domain containing 115 2 12
MIRT509269 NPM3 nucleophosmin/nucleoplasmin 3 2 4
MIRT512466 CCDC149 coiled-coil domain containing 149 2 2
MIRT513534 PRDM2 PR/SET domain 2 2 4
MIRT514218 ZNF83 zinc finger protein 83 2 4
MIRT518526 FLCN folliculin 2 6
MIRT524841 ARPP19 cAMP regulated phosphoprotein 19 2 2
MIRT524855 ARL5B ADP ribosylation factor like GTPase 5B 2 4
MIRT525048 FRK fyn related Src family tyrosine kinase 2 2
MIRT528635 SENP6 SUMO1/sentrin specific peptidase 6 2 2
MIRT529557 SNRNP48 small nuclear ribonucleoprotein U11/U12 subunit 48 2 2
MIRT532319 GHSR growth hormone secretagogue receptor 2 2
MIRT534232 SLC25A16 solute carrier family 25 member 16 2 2
MIRT534254 SLC12A7 solute carrier family 12 member 7 2 2
MIRT536223 LRRC41 leucine rich repeat containing 41 2 2
MIRT537658 ERBB2IP erbb2 interacting protein 2 2
MIRT537795 EIF1AX eukaryotic translation initiation factor 1A, X-linked 2 2
MIRT540404 PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 2 2
MIRT544563 POLDIP3 DNA polymerase delta interacting protein 3 2 2
MIRT546045 VPS4B vacuolar protein sorting 4 homolog B 2 2
MIRT546846 RAB4A RAB4A, member RAS oncogene family 2 2
MIRT548480 EEF2 eukaryotic translation elongation factor 2 2 2
MIRT549337 ARF6 ADP ribosylation factor 6 2 2
MIRT550855 SNAP47 synaptosome associated protein 47 2 4
MIRT551607 ZNF267 zinc finger protein 267 2 2
MIRT553222 TWF1 twinfilin actin binding protein 1 2 2
MIRT553874 SUPT7L SPT7 like, STAGA complex gamma subunit 2 4
MIRT557956 FAM222B family with sequence similarity 222 member B 2 2
MIRT559264 BAG4 BCL2 associated athanogene 4 2 4
MIRT562245 GRWD1 glutamate rich WD repeat containing 1 2 2
MIRT563184 YDJC YdjC chitooligosaccharide deacetylase homolog 2 2
MIRT563834 SMDT1 single-pass membrane protein with aspartate rich tail 1 2 2
MIRT563967 RAB6A RAB6A, member RAS oncogene family 2 2
MIRT564808 ZBTB21 zinc finger and BTB domain containing 21 2 2
MIRT565188 TSHZ1 teashirt zinc finger homeobox 1 2 2
MIRT565549 SMG1 SMG1, nonsense mediated mRNA decay associated PI3K related kinase 2 2
MIRT566969 LBR lamin B receptor 2 2
MIRT570926 ZNF284 zinc finger protein 284 2 2
MIRT612283 ZMAT3 zinc finger matrin-type 3 2 2
MIRT612695 PKNOX1 PBX/knotted 1 homeobox 1 2 2
MIRT625293 ZNF619 zinc finger protein 619 2 2
MIRT628496 LINS lines homolog 1 2 2
MIRT640282 FAM169B family with sequence similarity 169 member B 2 2
MIRT647212 CYP2U1 cytochrome P450 family 2 subfamily U member 1 2 2
MIRT654668 PSMB5 proteasome subunit beta 5 2 2
MIRT657516 HAS2 hyaluronan synthase 2 2 2
MIRT670337 C1orf106 chromosome 1 open reading frame 106 2 4
MIRT702010 MIDN midnolin 2 2
MIRT704253 DHCR24 24-dehydrocholesterol reductase 2 2
MIRT710205 ENAH ENAH, actin regulator 2 2
MIRT712126 TGFBR2 transforming growth factor beta receptor 2 2 2
MIRT714890 COQ10B coenzyme Q10B 2 2
MIRT716588 PAX6 paired box 6 2 2
MIRT720810 CIAO1 cytosolic iron-sulfur assembly component 1 2 2
MIRT724953 AHCY adenosylhomocysteinase 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-488 Glucose NULL 5793 Quantitative real-time PCR endothelial cells 24394957 2014 down-regulated
miR-488 Diethylstilbestrol approved 448537 Microarray mammosphere-derived epithelial cells (MDEC) 19549897 2009 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-488 Doxorubicin 31703 NSC123127 approved resistant High Chronic Myelogenous Leukemia cell line (K562)
hsa-miR-488 Chemotherapy sensitive High Epithelial Ovarian Cancer tissue
hsa-miR-488 Cisplatin 5460033 NSC119875 approved resistant Low Non-Small Cell Lung Cancer cell line (A549, H1299)
hsa-miR-488 Daunorubicin 30323 NSC82151 approved resistant High Acute Promyelocytic Leukemia cell line (HL60)
hsa-miR-488 Vemurafenib 42611257 NSC761431 approved sensitive High Melanoma cell line (A375)
hsa-miR-488 Taxane 9548828 sensitive High Breast Cancer tissue
hsa-miR-488 Doxorubicin 31703 NSC123127 approved sensitive High Anaplastic Thyroid Cancer tissue
hsa-mir-488 Paclitaxel 36314 NSC125973 approved sensitive cell line (A2780)
hsa-mir-488 Fluorouracil 3385 NSC19893 approved resistant cell line (OE19)
hsa-miR-488 Sunitinib 5329102 NSC750690 approved resistant tissue (CardA)
hsa-miR-488 Pegylated interferon alpha+Ribavirin sensitive tissue (chronic hepatitis C)
hsa-miR-488 Doxorubicin 31703 NSC123127 approved resistant cell line (K562)
hsa-miR-488 Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-488-3p Paclitaxel 36314 NSC125973 approved resistant High Prostate Cancer cell line (DU-145, PC-3)
hsa-miR-488-3p Cisplatin 5460033 NSC119875 approved sensitive Low Melanoma cell line (SK-Mel-28)
hsa-miR-488-3p Osimertinib 71496458 NSC779217 approved resistant cell line (HCC827)
hsa-miR-488-3p Neoadjuvant chemotherapy resistant tissue (breast cancer)
hsa-miR-488-3p Gemcitabine 60750 NSC613327 approved resistant cell line (PANC-1) (1500 ng/ml)

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