miRTarBase - #MIRT055374


—
pre-miRNA Information
pre-miRNA hsa-mir-6509   
Genomic Coordinates chr7: 135206994 - 135207078
Description Homo sapiens miR-6509 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-6509-3p
Sequence 52| UUCCACUGCCACUACCUAAUUU |73
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs778601614 1 dbSNP
rs754554776 3 dbSNP
rs767798995 3 dbSNP
rs145322812 4 dbSNP
rs773941257 5 dbSNP
rs768273593 9 dbSNP
rs984565062 12 dbSNP
rs748872915 13 dbSNP
rs774861125 14 dbSNP
rs13241975 20 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol PDCD4   
Synonyms H731
Description programmed cell death 4
Transcript NM_014456   
Other Transcripts NM_145341   
Expression
Putative miRNA Targets on PDCD4
3'UTR of PDCD4
(miRNA target sites are highlighted)		 
>PDCD4|NM_014456|3'UTR
   1 ATATAAGAACTCTTGCAGTCTTAGATGTTATAAAAATATATATCTGAATTGTAAGAGTTGTTAGCACAAGTTTTTTTTTT
  81 TTTTTTTTTTAAGCACTTGTTTTGGGTACAAGGCATTTCTGACATTTTATAAACCTACATTTAAGGGGAATTTTTAAAGG
 161 AAATGTTTTTTCTTTTTTTTTTGTTTTTCGAGGGGGCAAGGAGGGACAGAAAAGTAACCTCTTCTTAAGTGGAATATTCT
 241 AATAAGCTACCTTTTGTAAGTGCCATGTTTATTATCTAATCATTCCAAGTTTTGCATTGATGTCTGACTGCCACTCCTTT
 321 CTTTCAAGGACAGTGTTTTTTGTAGTAAAATCACTGGTTTATACAAAGCTTTATTTAGGGGGTAAAGTTAAGCTGCTAAA
 401 ACCCCATGTTGGCTGCTGCTGTTGAGATACTGTGCTTTGGGAGTAAAAAAAGAAAGTTATTTCTTTGTCTTAAAGAATTT
 481 TTAAAAAATTAGTCATGAGACTTATTCATCTTTCCAGGGAACATACTGATTGGTCTTAAAAGACTAGACAGTTAAGTAAA
 561 AGGTGGCTGGAACATCTATTTTTCTACAAAACTGGAAAAATGAACCTGGTTCTAGAAGAATGTACACCAAAATAAAACAT
 641 GTGAAGCAGTATTGATTCTTTATTGGGAGTACATTTTTTTAGGTCTCTTAAACTTTAATTTCACACAGTAAATTTTGAAT
 721 CTCATAAGGAAGCATATTTGAACCTAGTCAATTTAATCTTAGTGTTCCCTTGAAAACTTTTTTTCCCTACAAAATTTTAA
 801 GTGAAAAATACAATAGTAAATTAAGATTACACTGGGGAAAAAAATGCAGGTATCACTTTACTCCATTGTTATCTGACCTA
 881 GAGCTTAATTAAGTTTTAGAAATATGTAATACCTTCCATCATTCCATCATCCTTAAATTCTGTTACCAAATAATGGCTAA
 961 TGTTACAAAAAGTTATACTCCAGAGACCCAAAGCTTGACATTTACCTAATGTATGAGAAAATATTACCAATTAACAATAA
1041 AGAATGATCATATTTTTAACCTCTTTTACATAGCCTAATAACTCAGCAAGGCCTCAACGTCTGTGCTAATTTAAACTGCC
1121 AAATATTGACTGCAGCAAACAAGAATTATATTCAGAATTTATGAGGGTACTGTTAGGAGTATACTGCTTACAGGTTTAGA
1201 TATAGTCTGTTAGAATTAAAACCAAGTTTAGTGTTCATATTTACCTCATGGGCTTTATCAAGCCCATATTACCTCAGCTT
1281 ATATATAGTTACCATTTTTAGGTTTTTAATTGTTTGACACTTGGATGATAAATGCAGTCATTTTATTCTCAAGTGCTTAA
1361 AATTAATGTAATTAAAAGCTTAGCTGACTACAGAATAGGTGAGGGTTTCTTAAAAATGAGATTTAAGGGCTGGGCACGGT
1441 GGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGTGGGCGGATCACTTGAGGTTGGGAGTTCATGACCAGCTTGA
1521 CCAACATGAAGAAACCCTGTCTCTATTAAAAATACAAAAGTAGCCAGGCATGGTGGCGCATGCGTGTAATCCCAGCTACT
1601 TGGGAGGCTGAGGCAGGAGAATTGCTTGAACCTGGGAGGCAGAGGTTGCAGTGAGTCGAGATGGTGCCATTGCTCTCGTT
1681 TGGGCAACAAGAGTGAAACTCTTGTCTCAAAAAAAAAAAAAAATGAGGTTTAAGACAGTTTTGTCATTACTGGTGGGATC
1761 TGGTCACACAAGATAGCATTAAACGTGACATGGCACATAAAATTGGTTAAAAAATTTTGTTTTTTAATTACGTAATGTAA
1841 AAGCCCAACAAACACTTTATGCAAGATTGGAATGTATCTTCAAATTCAGATTTAATAAACATGTAAAGATCCTCTGTAAA
1921 AAAAAAAAAAAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' uuuaauccaucaccgUCACCUu 5'
                         |||||| 
Target 5' agtaacctcttcttaAGTGGAa 3'
 213 - 234 120.00 -8.30
2 
miRNA  3' uuuAAUCCAUCACC---GUCACCuu 5'
             ||| | : |||   |:||||  
Target 5' gatTTAAGGGCTGGGCACGGTGGct 3'
 1420 - 1444 119.00 -13.20
3 
miRNA  3' uuuaaUCCAU---CACCGUCACcuu 5'
               ||| |   || ||||||   
Target 5' ctgggAGGCAGAGGTTGCAGTGagt 3'
 1632 - 1656 117.00 -12.60
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30513930 41 COSMIC
COSN20077120 61 COSMIC
COSN31586225 62 COSMIC
COSN20107546 90 COSMIC
COSN20077167 91 COSMIC
COSN1112386 124 COSMIC
COSN31586717 163 COSMIC
COSN29083098 183 COSMIC
COSN6056641 348 COSMIC
COSN31589683 369 COSMIC
COSN1112388 373 COSMIC
COSN31577787 380 COSMIC
COSN31569900 453 COSMIC
COSN31534635 476 COSMIC
COSN8149300 579 COSMIC
COSN27555657 1066 COSMIC
COSN6056642 1123 COSMIC
COSN29854732 1331 COSMIC
COSN1471208 1485 COSMIC
COSN20788217 1516 COSMIC
COSN8149301 1520 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs780773533 1 dbSNP
rs192041921 4 dbSNP
rs372012361 5 dbSNP
rs1274530692 8 dbSNP
rs780271274 11 dbSNP
rs1461423681 13 dbSNP
rs749729920 14 dbSNP
rs1252920446 16 dbSNP
rs201739274 17 dbSNP
rs774971106 25 dbSNP
rs748132091 28 dbSNP
rs773643180 28 dbSNP
rs1235425484 29 dbSNP
rs1473481400 31 dbSNP
rs1034503022 32 dbSNP
rs1389478794 33 dbSNP
rs12263197 36 dbSNP
rs1427668941 37 dbSNP
rs376964203 40 dbSNP
rs760994347 41 dbSNP
rs1293533284 50 dbSNP
rs766763981 52 dbSNP
rs1177722312 54 dbSNP
rs1481462408 57 dbSNP
rs945794629 59 dbSNP
rs1254056882 60 dbSNP
rs775140901 61 dbSNP
rs762843302 63 dbSNP
rs763911359 65 dbSNP
rs1296880355 66 dbSNP
rs751537495 68 dbSNP
rs1491521147 70 dbSNP
rs759575771 70 dbSNP
rs761257424 70 dbSNP
rs771292422 70 dbSNP
rs1375667883 71 dbSNP
rs397716645 71 dbSNP
rs5787876 71 dbSNP
rs763160233 71 dbSNP
rs775747835 71 dbSNP
rs776805156 71 dbSNP
rs977086596 71 dbSNP
rs1175129960 74 dbSNP
rs767018039 75 dbSNP
rs750018222 76 dbSNP
rs1344721798 79 dbSNP
rs779798593 81 dbSNP
rs1014210812 87 dbSNP
rs1186940826 91 dbSNP
rs1276051599 91 dbSNP
rs1489992836 91 dbSNP
rs757243971 91 dbSNP
rs1222273709 92 dbSNP
rs1269984987 97 dbSNP
rs1002808943 100 dbSNP
rs749594671 103 dbSNP
rs1192500325 105 dbSNP
rs755392885 106 dbSNP
rs1427468584 107 dbSNP
rs779252577 110 dbSNP
rs1170528262 112 dbSNP
rs556498033 114 dbSNP
rs577882072 115 dbSNP
rs1311283326 130 dbSNP
rs72819730 134 dbSNP
rs1032781331 139 dbSNP
rs1314276292 146 dbSNP
rs1397780523 148 dbSNP
rs1383835412 152 dbSNP
rs554044351 153 dbSNP
rs373862908 158 dbSNP
rs749268636 160 dbSNP
rs1366639391 161 dbSNP
rs1164132811 163 dbSNP
rs1475380272 166 dbSNP
rs1010397344 167 dbSNP
rs1190280165 169 dbSNP
rs1205781530 173 dbSNP
rs1261363981 173 dbSNP
rs138010548 173 dbSNP
rs1486930275 173 dbSNP
rs550230568 173 dbSNP
rs1213640065 180 dbSNP
rs1052550 182 dbSNP
rs1421546024 183 dbSNP
rs1225757702 184 dbSNP
rs966695346 184 dbSNP
rs543153032 190 dbSNP
rs976398998 191 dbSNP
rs1418147360 201 dbSNP
rs1387967989 207 dbSNP
rs12248739 215 dbSNP
rs1167597601 219 dbSNP
rs548643783 219 dbSNP
rs1396652128 220 dbSNP
rs1168248170 240 dbSNP
rs953420949 242 dbSNP
rs1461752056 244 dbSNP
rs1194177840 249 dbSNP
rs1299250990 257 dbSNP
rs1251247168 258 dbSNP
rs1399213623 261 dbSNP
rs1469284066 263 dbSNP
rs1394389347 268 dbSNP
rs146211346 270 dbSNP
rs1339142667 276 dbSNP
rs1251468960 285 dbSNP
rs529863924 287 dbSNP
rs1229185213 293 dbSNP
rs921091660 294 dbSNP
rs768075579 298 dbSNP
rs61469604 303 dbSNP
rs940800810 309 dbSNP
rs1306720036 310 dbSNP
rs756545115 311 dbSNP
rs1409090372 323 dbSNP
rs1396971995 332 dbSNP
rs1168667096 333 dbSNP
rs1463689523 335 dbSNP
rs368483051 336 dbSNP
rs746143494 364 dbSNP
rs1454815676 365 dbSNP
rs1255365411 369 dbSNP
rs1036344767 374 dbSNP
rs1209586899 379 dbSNP
rs1437561198 380 dbSNP
rs1257563402 382 dbSNP
rs1345268277 386 dbSNP
rs1476020013 387 dbSNP
rs1191038232 388 dbSNP
rs1279237536 398 dbSNP
rs1394888963 406 dbSNP
rs899189743 408 dbSNP
rs1349430458 409 dbSNP
rs1277645062 419 dbSNP
rs1336314793 420 dbSNP
rs1441424023 420 dbSNP
rs1330610619 425 dbSNP
rs1373862892 431 dbSNP
rs995078972 442 dbSNP
rs1435356761 448 dbSNP
rs1396989471 451 dbSNP
rs1157300179 460 dbSNP
rs72819732 470 dbSNP
rs905502907 476 dbSNP
rs958946663 476 dbSNP
rs11548764 485 dbSNP
rs1184412616 489 dbSNP
rs1171507735 501 dbSNP
rs1375338553 502 dbSNP
rs1256289038 504 dbSNP
rs1433368499 506 dbSNP
rs796971952 518 dbSNP
rs1376130997 519 dbSNP
rs1281481400 520 dbSNP
rs1054152305 524 dbSNP
rs1351290183 531 dbSNP
rs1416634506 540 dbSNP
rs1231152880 548 dbSNP
rs1354595918 550 dbSNP
rs1312449120 557 dbSNP
rs1361159956 560 dbSNP
rs1415660391 560 dbSNP
rs1316288062 569 dbSNP
rs1400255863 574 dbSNP
rs892875475 579 dbSNP
rs1162010579 587 dbSNP
rs1010030514 588 dbSNP
rs1361479457 599 dbSNP
rs1214962786 606 dbSNP
rs1297423318 610 dbSNP
rs1020458751 613 dbSNP
rs1240057210 614 dbSNP
rs1214449027 619 dbSNP
rs1447082126 619 dbSNP
rs1286187826 621 dbSNP
rs1211765099 626 dbSNP
rs1467628372 629 dbSNP
rs1333829858 635 dbSNP
rs759553259 639 dbSNP
rs1233463322 641 dbSNP
rs1381601649 646 dbSNP
rs1280489142 647 dbSNP
rs998150940 650 dbSNP
rs1268710457 659 dbSNP
rs1430030649 662 dbSNP
rs1486371655 672 dbSNP
rs1029257908 674 dbSNP
rs1323085965 677 dbSNP
rs1460370318 681 dbSNP
rs1394452365 686 dbSNP
rs953785133 691 dbSNP
rs1407499706 711 dbSNP
rs1416863901 713 dbSNP
rs984736615 716 dbSNP
rs1024492157 718 dbSNP
rs1016256413 725 dbSNP
rs761358804 727 dbSNP
rs967132003 729 dbSNP
rs532537004 734 dbSNP
rs139237079 738 dbSNP
rs972129810 745 dbSNP
rs1173577363 746 dbSNP
rs565963166 750 dbSNP
rs1214233230 758 dbSNP
rs957299247 762 dbSNP
rs866368294 765 dbSNP
rs1299886324 770 dbSNP
rs975301420 775 dbSNP
rs1438870762 778 dbSNP
rs949933576 778 dbSNP
rs1436694386 782 dbSNP
rs1353143165 786 dbSNP
rs1169261968 787 dbSNP
rs1156949087 790 dbSNP
rs921142646 791 dbSNP
rs1391686042 793 dbSNP
rs1171185490 804 dbSNP
rs1453342679 810 dbSNP
rs933920544 814 dbSNP
rs1253476559 815 dbSNP
rs1192866878 825 dbSNP
rs981737163 826 dbSNP
rs1431710867 829 dbSNP
rs1205013967 834 dbSNP
rs1050859596 839 dbSNP
rs56875008 858 dbSNP
rs1232087130 860 dbSNP
rs940770586 862 dbSNP
rs1347260445 865 dbSNP
rs1439811981 872 dbSNP
rs1304743483 877 dbSNP
rs1304112024 878 dbSNP
rs1389067216 879 dbSNP
rs1054121612 885 dbSNP
rs1297941842 888 dbSNP
rs376183497 890 dbSNP
rs72377323 890 dbSNP
rs747522218 890 dbSNP
rs549069926 894 dbSNP
rs1036886771 901 dbSNP
rs1237391718 919 dbSNP
rs1310703143 926 dbSNP
rs899161298 927 dbSNP
rs1433500110 932 dbSNP
rs1395185722 950 dbSNP
rs373508013 960 dbSNP
rs1407235544 961 dbSNP
rs1417208347 961 dbSNP
rs994799070 962 dbSNP
rs531826405 968 dbSNP
rs1282905790 970 dbSNP
rs1317214605 977 dbSNP
rs796147119 981 dbSNP
rs1244565042 986 dbSNP
rs1485361887 990 dbSNP
rs1341930842 995 dbSNP
rs1256632329 1007 dbSNP
rs1041503944 1008 dbSNP
rs901977228 1011 dbSNP
rs571420900 1013 dbSNP
rs894701212 1014 dbSNP
rs1413826408 1019 dbSNP
rs537866454 1029 dbSNP
rs1269091786 1039 dbSNP
rs1304061122 1039 dbSNP
rs1344463009 1043 dbSNP
rs1175594613 1050 dbSNP
rs1014533843 1059 dbSNP
rs1415433303 1061 dbSNP
rs1473421423 1061 dbSNP
rs1407340708 1067 dbSNP
rs796343911 1072 dbSNP
rs1257198173 1073 dbSNP
rs1202245029 1076 dbSNP
rs1484937899 1078 dbSNP
rs1315592630 1080 dbSNP
rs367711802 1080 dbSNP
rs568306693 1080 dbSNP
rs1331622994 1081 dbSNP
rs962020555 1097 dbSNP
rs745440231 1098 dbSNP
rs972098737 1099 dbSNP
rs1355688308 1100 dbSNP
rs1314431931 1105 dbSNP
rs1161567474 1106 dbSNP
rs967980002 1109 dbSNP
rs1379965358 1111 dbSNP
rs2146544 1119 dbSNP
rs143977617 1132 dbSNP
rs1392260035 1141 dbSNP
rs1458719530 1141 dbSNP
rs1033217144 1146 dbSNP
rs1461828075 1153 dbSNP
rs1369205435 1158 dbSNP
rs1326311133 1161 dbSNP
rs957148553 1166 dbSNP
rs1373154558 1179 dbSNP
rs971248810 1180 dbSNP
rs1261170021 1189 dbSNP
rs1189344889 1190 dbSNP
rs975018707 1191 dbSNP
rs981281339 1193 dbSNP
rs1278505215 1197 dbSNP
rs1213381496 1201 dbSNP
rs1373445108 1202 dbSNP
rs115021775 1204 dbSNP
rs958605891 1205 dbSNP
rs990076859 1207 dbSNP
rs914204576 1210 dbSNP
rs1333642953 1227 dbSNP
rs1436718766 1233 dbSNP
rs775616314 1241 dbSNP
rs1325145977 1244 dbSNP
rs1441291023 1250 dbSNP
rs116669104 1252 dbSNP
rs1165182596 1258 dbSNP
rs1460632964 1259 dbSNP
rs572244618 1264 dbSNP
rs1451409709 1269 dbSNP
rs923025458 1277 dbSNP
rs1193579254 1279 dbSNP
rs532881191 1285 dbSNP
rs1194487317 1286 dbSNP
rs1050607723 1289 dbSNP
rs117501349 1292 dbSNP
rs973935747 1293 dbSNP
rs1345137187 1294 dbSNP
rs576331563 1300 dbSNP
rs1470554249 1303 dbSNP
rs1233923377 1310 dbSNP
rs1302527597 1310 dbSNP
rs920641886 1313 dbSNP
rs1326585305 1316 dbSNP
rs1416027735 1319 dbSNP
rs1390666987 1320 dbSNP
rs897802703 1326 dbSNP
rs1474987377 1330 dbSNP
rs571704165 1345 dbSNP
rs1165468211 1348 dbSNP
rs930727918 1351 dbSNP
rs1396393823 1355 dbSNP
rs535870892 1357 dbSNP
rs1055780881 1358 dbSNP
rs894504715 1363 dbSNP
rs950268884 1364 dbSNP
rs993447482 1365 dbSNP
rs1379939259 1366 dbSNP
rs543427963 1367 dbSNP
rs1328106739 1369 dbSNP
rs1437682329 1369 dbSNP
rs1206910800 1371 dbSNP
rs768527963 1372 dbSNP
rs903350635 1374 dbSNP
rs760414646 1376 dbSNP
rs1278939229 1377 dbSNP
rs184164741 1385 dbSNP
rs763246128 1393 dbSNP
rs958532831 1397 dbSNP
rs532647939 1403 dbSNP
rs1290877178 1404 dbSNP
rs1289189660 1405 dbSNP
rs892861715 1410 dbSNP
rs914476331 1417 dbSNP
rs1233514747 1419 dbSNP
rs996573900 1423 dbSNP
rs867314467 1429 dbSNP
rs541373922 1434 dbSNP
rs146414879 1438 dbSNP
rs188713884 1439 dbSNP
rs922962287 1448 dbSNP
rs1184824515 1452 dbSNP
rs1473991969 1453 dbSNP
rs1475087791 1457 dbSNP
rs1256381142 1464 dbSNP
rs1210122140 1465 dbSNP
rs1443703773 1476 dbSNP
rs1258448635 1477 dbSNP
rs1015886528 1484 dbSNP
rs1272955212 1485 dbSNP
rs961325608 1486 dbSNP
rs974284621 1489 dbSNP
rs774549387 1492 dbSNP
rs910691078 1499 dbSNP
rs919788416 1503 dbSNP
rs930696809 1510 dbSNP
rs991600931 1517 dbSNP
rs1316811264 1522 dbSNP
rs548773635 1522 dbSNP
rs915907321 1527 dbSNP
rs950071375 1532 dbSNP
rs1037856868 1536 dbSNP
rs1188942375 1537 dbSNP
rs1412609944 1538 dbSNP
rs1182140294 1539 dbSNP
rs1420208111 1539 dbSNP
rs1473478135 1544 dbSNP
rs1474322629 1545 dbSNP
rs898068979 1554 dbSNP
rs1045735530 1556 dbSNP
rs1465247978 1561 dbSNP
rs993744051 1569 dbSNP
rs903401797 1575 dbSNP
rs377721423 1578 dbSNP
rs1289403011 1582 dbSNP
rs906527793 1585 dbSNP
rs1310614704 1588 dbSNP
rs934945278 1591 dbSNP
rs1414802660 1592 dbSNP
rs1366467780 1599 dbSNP
rs1034191190 1600 dbSNP
rs561051882 1606 dbSNP
rs958134628 1607 dbSNP
rs1165971583 1613 dbSNP
rs55858908 1618 dbSNP
rs1324275923 1620 dbSNP
rs192265483 1623 dbSNP
rs1021504349 1627 dbSNP
rs1191722221 1629 dbSNP
rs149734425 1632 dbSNP
rs1269951480 1647 dbSNP
rs1247026005 1648 dbSNP
rs1340769730 1649 dbSNP
rs1453481319 1654 dbSNP
rs182879722 1656 dbSNP
rs1227752499 1658 dbSNP
rs1278743357 1659 dbSNP
rs1028068006 1660 dbSNP
rs11548763 1664 dbSNP
rs145626064 1678 dbSNP
rs1232697157 1679 dbSNP
rs1211639143 1685 dbSNP
rs1258557671 1686 dbSNP
rs1445472299 1687 dbSNP
rs1192252744 1689 dbSNP
rs1367550079 1689 dbSNP
rs1294429727 1691 dbSNP
rs187023714 1694 dbSNP
rs1476382871 1695 dbSNP
rs1171696543 1701 dbSNP
rs985875614 1702 dbSNP
rs1307089275 1703 dbSNP
rs1394327171 1705 dbSNP
rs1429801064 1708 dbSNP
rs1434828084 1708 dbSNP
rs1491333548 1708 dbSNP
rs754057095 1708 dbSNP
rs1204760448 1709 dbSNP
rs1249869792 1709 dbSNP
rs1420323869 1709 dbSNP
rs1483525287 1709 dbSNP
rs200583503 1709 dbSNP
rs201736448 1709 dbSNP
rs537232273 1709 dbSNP
rs1015272907 1711 dbSNP
rs1382380498 1712 dbSNP
rs961565790 1723 dbSNP
rs1318149006 1724 dbSNP
rs1475634434 1725 dbSNP
rs941813166 1726 dbSNP
rs973533031 1729 dbSNP
rs1301926492 1730 dbSNP
rs1410013506 1737 dbSNP
rs919464628 1742 dbSNP
rs1396238820 1750 dbSNP
rs974041950 1752 dbSNP
rs565692123 1759 dbSNP
rs929534218 1770 dbSNP
rs1047092035 1771 dbSNP
rs1348891381 1773 dbSNP
rs558844759 1780 dbSNP
rs554731075 1785 dbSNP
rs1182664658 1786 dbSNP
rs577554924 1794 dbSNP
rs1254253150 1797 dbSNP
rs1180188349 1804 dbSNP
rs1191469549 1807 dbSNP
rs1252318986 1815 dbSNP
rs1454637875 1816 dbSNP
rs1212911329 1818 dbSNP
rs991569865 1822 dbSNP
rs915959835 1826 dbSNP
rs1267842582 1828 dbSNP
rs754084731 1832 dbSNP
rs576468849 1833 dbSNP
rs1394930265 1835 dbSNP
rs757693138 1837 dbSNP
rs1021430769 1838 dbSNP
rs1451482480 1839 dbSNP
rs569691826 1841 dbSNP
rs998754097 1845 dbSNP
rs1386634026 1852 dbSNP
rs537134116 1859 dbSNP
rs558527459 1861 dbSNP
rs1163010892 1875 dbSNP
rs1423286685 1879 dbSNP
rs764810501 1879 dbSNP
rs34559036 1881 dbSNP
rs986187058 1892 dbSNP
rs1463887438 1901 dbSNP
rs1247952586 1912 dbSNP
rs1209742766 1915 dbSNP
rs1263288517 1917 dbSNP
rs1331728099 1917 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM545216. RNA binding protein: AGO2. Condition:miR-124 transfection ...

- Hafner M; Landthaler M; Burger L; Khorshid et al., 2010, Cell.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' uuuaauccaucaccgUCACCUu 5'
                         |||||| 
Target 5' --uaaccucuucuuaAGUGGAa 3'
 		1 - 20
Article - Hafner M; Landthaler M; Burger L; Khorshid et al.
- Cell, 2010
RNA transcripts are subject to posttranscriptional gene regulation involving hundreds of RNA-binding proteins (RBPs) and microRNA-containing ribonucleoprotein complexes (miRNPs) expressed in a cell-type dependent fashion. We developed a cell-based crosslinking approach to determine at high resolution and transcriptome-wide the binding sites of cellular RBPs and miRNPs. The crosslinked sites are revealed by thymidine to cytidine transitions in the cDNAs prepared from immunopurified RNPs of 4-thiouridine-treated cells. We determined the binding sites and regulatory consequences for several intensely studied RBPs and miRNPs, including PUM2, QKI, IGF2BP1-3, AGO/EIF2C1-4 and TNRC6A-C. Our study revealed that these factors bind thousands of sites containing defined sequence motifs and have distinct preferences for exonic versus intronic or coding versus untranslated transcript regions. The precise mapping of binding sites across the transcriptome will be critical to the interpretation of the rapidly emerging data on genetic variation between individuals and how these variations contribute to complex genetic diseases.
LinkOut: [PMID: 20371350]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Disease 27250.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM714644. RNA binding protein: AGO2. Condition:completeT1 ...

- Kishore S; Jaskiewicz L; Burger L; Hausser et al., 2011, Nature methods.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' uuuaauccaucaccgUCACCUu 5'
                         |||||| 
Target 5' ---aaccucuucuuaAGUGGAa 3'
 		1 - 19
Article - Kishore S; Jaskiewicz L; Burger L; Hausser et al.
- Nature methods, 2011
Cross-linking and immunoprecipitation (CLIP) is increasingly used to map transcriptome-wide binding sites of RNA-binding proteins. We developed a method for CLIP data analysis, and applied it to compare CLIP with photoactivatable ribonucleoside-enhanced CLIP (PAR-CLIP) and to uncover how differences in cross-linking and ribonuclease digestion affect the identified sites. We found only small differences in accuracies of these methods in identifying binding sites of HuR, which binds low-complexity sequences, and Argonaute 2, which has a complex binding specificity. We found that cross-link-induced mutations led to single-nucleotide resolution for both PAR-CLIP and CLIP. Our results confirm the expectation from original CLIP publications that RNA-binding proteins do not protect their binding sites sufficiently under the denaturing conditions used during the CLIP procedure, and we show that extensive digestion with sequence-specific RNases strongly biases the recovered binding sites. This bias can be substantially reduced by milder nuclease digestion conditions.
LinkOut: [PMID: 21572407]
CLIP-seq Support 1 for dataset GSM545216
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / miR-124 transfection
Location of target site ENST00000280154.7 | 3UTR | UAACCUCUUCUUAAGUGGAAUAUUCUAAUAAGCUACCUUUU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 20371350 / GSE21578
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM714644
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / completeT1, repA
Location of target site ENST00000280154.7 | 3UTR | AACCUCUUCUUAAGUGGAAUAUUCUAAUAAGCUACCUUUUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 21572407 / GSE28865
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
82 hsa-miR-6509-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT055374 PDCD4 programmed cell death 4 2 4
MIRT378341 MARCKS myristoylated alanine rich protein kinase C substrate 2 2
MIRT444668 CDKL2 cyclin dependent kinase like 2 2 2
MIRT446953 CD248 CD248 molecule 2 2
MIRT460332 CAMK4 calcium/calmodulin dependent protein kinase IV 2 6
MIRT464078 VPS4A vacuolar protein sorting 4 homolog A 2 2
MIRT464586 UBN2 ubinuclein 2 2 2
MIRT468482 SESN3 sestrin 3 2 2
MIRT468962 RPRD2 regulation of nuclear pre-mRNA domain containing 2 2 2
MIRT475455 HSPA8 heat shock protein family A (Hsp70) member 8 2 2
MIRT482403 ADRB1 adrenoceptor beta 1 2 10
MIRT486992 ZFAND2B zinc finger AN1-type containing 2B 2 2
MIRT489397 TUBB2A tubulin beta 2A class IIa 2 2
MIRT526319 UGT2A1 UDP glucuronosyltransferase family 2 member A1 complex locus 2 2
MIRT526560 UGT2A2 UDP glucuronosyltransferase family 2 member A2 2 2
MIRT526732 ZNF138 zinc finger protein 138 2 8
MIRT531581 STXBP5L syntaxin binding protein 5 like 2 2
MIRT532011 NOX5 NADPH oxidase 5 2 2
MIRT533407 TXLNG taxilin gamma 2 2
MIRT533436 TRPC5 transient receptor potential cation channel subfamily C member 5 2 2
MIRT533866 TBL1XR1 transducin beta like 1 X-linked receptor 1 2 2
MIRT539254 ANKRD50 ankyrin repeat domain 50 2 2
MIRT541451 C15orf48 chromosome 15 open reading frame 48 2 2
MIRT566794 MIER3 MIER family member 3 2 2
MIRT569294 SURF6 surfeit 6 2 2
MIRT571336 RABGEF1 RAB guanine nucleotide exchange factor 1 2 2
MIRT572802 PPP3CB protein phosphatase 3 catalytic subunit beta 2 2
MIRT572813 MYO1C myosin IC 2 2
MIRT574219 DMRT2 doublesex and mab-3 related transcription factor 2 2 2
MIRT607259 GRAMD1B GRAM domain containing 1B 2 4
MIRT609307 CHD4 chromodomain helicase DNA binding protein 4 2 2
MIRT615459 REPS1 RALBP1 associated Eps domain containing 1 2 2
MIRT616861 RPLP1 ribosomal protein lateral stalk subunit P1 2 2
MIRT619415 NOS1AP nitric oxide synthase 1 adaptor protein 2 2
MIRT619652 COX19 COX19, cytochrome c oxidase assembly factor 2 2
MIRT625325 TNFRSF13B TNF receptor superfamily member 13B 2 2
MIRT638980 ARFIP2 ADP ribosylation factor interacting protein 2 2 2
MIRT639458 ZNF429 zinc finger protein 429 2 2
MIRT640550 SMCR8 Smith-Magenis syndrome chromosome region, candidate 8 2 2
MIRT641473 B4GALNT3 beta-1,4-N-acetyl-galactosaminyltransferase 3 2 2
MIRT642720 ATXN3 ataxin 3 2 2
MIRT643048 SMN1 survival of motor neuron 1, telomeric 2 2
MIRT644921 SMN2 survival of motor neuron 2, centromeric 2 2
MIRT645875 ZNF275 zinc finger protein 275 2 2
MIRT649824 LIPG lipase G, endothelial type 2 2
MIRT649851 GYS2 glycogen synthase 2 2 2
MIRT649972 TRAFD1 TRAF-type zinc finger domain containing 1 2 2
MIRT650675 ZNF259 ZPR1 zinc finger 1 1
MIRT651319 ZCCHC2 zinc finger CCHC-type containing 2 2 2
MIRT652876 TAB1 TGF-beta activated kinase 1 (MAP3K7) binding protein 1 2 2
MIRT652881 SYVN1 synoviolin 1 2 2
MIRT654144 RPAP2 RNA polymerase II associated protein 2 2 2
MIRT657080 JMY junction mediating and regulatory protein, p53 cofactor 2 2
MIRT657181 INO80C INO80 complex subunit C 2 2
MIRT657830 GJD3 gap junction protein delta 3 2 2
MIRT657897 GDF7 growth differentiation factor 7 2 2
MIRT659631 CDKN2AIP CDKN2A interacting protein 2 2
MIRT663115 SPTA1 spectrin alpha, erythrocytic 1 2 2
MIRT664739 METTL16 methyltransferase like 16 2 2
MIRT667551 LRAT lecithin retinol acyltransferase 2 2
MIRT668552 ERCC1 ERCC excision repair 1, endonuclease non-catalytic subunit 2 2
MIRT682893 XIAP X-linked inhibitor of apoptosis 2 2
MIRT683092 PRRG4 proline rich and Gla domain 4 2 2
MIRT683102 TIMM10B translocase of inner mitochondrial membrane 10B 2 2
MIRT697648 WNK1 WNK lysine deficient protein kinase 1 2 2
MIRT709158 ZNF419 zinc finger protein 419 2 2
MIRT713220 RCAN2 regulator of calcineurin 2 2 2
MIRT713277 LAIR1 leukocyte associated immunoglobulin like receptor 1 2 2
MIRT715008 CYP1B1 cytochrome P450 family 1 subfamily B member 1 2 2
MIRT715051 SYNJ2BP synaptojanin 2 binding protein 2 2
MIRT715696 PNMAL2 paraneoplastic Ma antigen family member 8B 2 2
MIRT717250 TMEM246 transmembrane protein 246 2 2
MIRT717322 PGK1 phosphoglycerate kinase 1 2 2
MIRT717587 MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like 2 2
MIRT718122 CHST4 carbohydrate sulfotransferase 4 2 2
MIRT718418 CALN1 calneuron 1 2 2
MIRT718750 ZNF490 zinc finger protein 490 2 2
MIRT720048 PPP1R3F protein phosphatase 1 regulatory subunit 3F 2 2
MIRT721497 THRB thyroid hormone receptor beta 2 2
MIRT722531 EPRS glutamyl-prolyl-tRNA synthetase 2 2
MIRT723279 KRTAP21-2 keratin associated protein 21-2 2 2
MIRT724813 MSX2 msh homeobox 2 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-6509-3p Temozolomide 5394 NSC362856 approved sensitive cell line (U251)
hsa-miR-6509-3p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-6509-3p Osimertinib 71496458 NSC779217 approved resistant cell line (PC9)
hsa-miR-6509-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-6509-3p Gemcitabine 60750 NSC613327 approved resistant cell line (PANC-1) (1500 ng/ml)

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