pre-miRNA Information | |
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pre-miRNA | hsa-mir-605 |
Genomic Coordinates | chr10: 51299573 - 51299655 |
Synonyms | MIRN605, hsa-mir-605, MIR605 |
Description | Homo sapiens miR-605 stem-loop |
Comment | None |
RNA Secondary Structure | |
Associated Diseases |
Mature miRNA Information | |||||||||||||||||||||||||||||||||||||
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Mature miRNA | hsa-miR-605-5p | ||||||||||||||||||||||||||||||||||||
Sequence | 16| UAAAUCCCAUGGUGCCUUCUCCU |38 | ||||||||||||||||||||||||||||||||||||
Evidence | Experimental | ||||||||||||||||||||||||||||||||||||
Experiments | SAGE | ||||||||||||||||||||||||||||||||||||
Editing Events in miRNAs |
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SNPs in miRNA |
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Putative Targets |
miRNA Expression profile | |
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Human miRNA Tissue Atlas | |
Circulating MicroRNA Expression Profiling |
Gene Information | |||||||||||||||||||||
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Gene Symbol | CEP55 | ||||||||||||||||||||
Synonyms | C10orf3, CT111, URCC6 | ||||||||||||||||||||
Description | centrosomal protein 55 | ||||||||||||||||||||
Transcript | NM_001127182 | ||||||||||||||||||||
Other Transcripts | NM_018131 | ||||||||||||||||||||
Expression | |||||||||||||||||||||
Putative miRNA Targets on CEP55 | |||||||||||||||||||||
3'UTR of CEP55 (miRNA target sites are highlighted) |
>CEP55|NM_001127182|3'UTR 1 CAAAATAAGTATTTGTTTTGATATTAAAAGATTCAATACTGTATTTTCTGTTAGCTTGTGGGCATTTTGAATTATATATT 81 TCACATTTTGCATAAAACTGCCTATCTACCTTTGACACTCCAGCATGCTAGTGAATCATGTATCTTTTAGGCTGCTGTGC 161 ATTTCTCTTGGCAGTGATACCTCCCTGACATGGTTCATCATCAGGCTGCAATGACAGAATGTGGTGAGCAGCGTCTACTG 241 AGACTACTAACATTTTGCACTGTCAAAATACTTGGTGAGGAAAAGATAGCTCAGGTTATTGCTAATGGGTTAATGCACCA 321 GCAAGCAAAATATTTTATGTTTTGGGGGTTTTGAAAAATCAAAGATAATTAACCAAGGATCTTAACTGTGTTCGCATTTT 401 TTATCCAAGCACTTAGAAAACCTACAATCCTAATTTTGATGTCCATTGTTAAGAGGTGGTGATAGATACTATTTTTTTTT 481 TCATATTGTATAGCGGTTATTAGAAAAGTTGGGGATTTTCTTGATCTTTATTGCTGCTTACCATTGAAACTTAACCCAGC 561 TGTGTTCCCCAACTCTGTTCTGCGCACGAAACAGTATCTGTTTGAGGCATAATCTTAAGTGGCCACACACAATGTTTTCT 641 CTTATGTTATCTGGCAGTAACTGTAACTTGAATTACATTAGCACATTCTGCTTAGCTAAAATTGTTAAAATAAACTTTAA 721 TAAACCCATGTAGCCCTCTCATTTGATTGACAGTATTTTAGTTATTTTTGGCATTCTTAAAGCTGGGCAATGTAATGATC 801 AGATCTTTGTTTGTCTGAACAGGTATTTTTATACATGCTTTTTGTAAACCAAAAACTTTTAAATTTCTTCAGGTTTTCTA 881 ACATGCTTACCACTGGGCTACTGTAAATGAGAAAAGAATAAAATTATTTAATGTTTTAAAAAAAAAAAAAAAAAAAA Target sites
Provided by authors
Predicted by miRanda
DRVs
SNPs
DRVs & SNPs
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miRNA-target interactions (Predicted by miRanda) |
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DRVs in gene 3'UTRs | |||||||||||||||||||||
SNPs in gene 3'UTRs |
Experimental Support 1 for Functional miRNA-Target Interaction | |
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miRNA:Target | ---- |
Validation Method |
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Conditions | HEK293 |
Location of target site | 3'UTR |
Tools used in this research | TargetScan , miRTarCLIP , Piranha |
Original Description (Extracted from the article) |
...
PAR-CLIP data was present in GSM545216. RNA binding protein: AGO2. Condition:miR-124 transfection
... - Hafner M; Landthaler M; Burger L; Khorshid et al., 2010, Cell. |
Article |
- Hafner M; Landthaler M; Burger L; Khorshid et al. - Cell, 2010
RNA transcripts are subject to posttranscriptional gene regulation involving hundreds of RNA-binding proteins (RBPs) and microRNA-containing ribonucleoprotein complexes (miRNPs) expressed in a cell-type dependent fashion. We developed a cell-based crosslinking approach to determine at high resolution and transcriptome-wide the binding sites of cellular RBPs and miRNPs. The crosslinked sites are revealed by thymidine to cytidine transitions in the cDNAs prepared from immunopurified RNPs of 4-thiouridine-treated cells. We determined the binding sites and regulatory consequences for several intensely studied RBPs and miRNPs, including PUM2, QKI, IGF2BP1-3, AGO/EIF2C1-4 and TNRC6A-C. Our study revealed that these factors bind thousands of sites containing defined sequence motifs and have distinct preferences for exonic versus intronic or coding versus untranslated transcript regions. The precise mapping of binding sites across the transcriptome will be critical to the interpretation of the rapidly emerging data on genetic variation between individuals and how these variations contribute to complex genetic diseases.
LinkOut: [PMID: 20371350]
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CLIP-seq Support 1 for dataset GSM545216 | |
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Method / RBP | PAR-CLIP / AGO2 |
Cell line / Condition | HEK293 / miR-124 transfection |
Location of target site | ENST00000371485.3 | 3UTR | AUUUUCUUGAUCUUUAUUGCUGCUUACCAUUG |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Article / Accession Series | PMID: 20371350 / GSE21578 |
CLIP-seq Viewer | Link |
MiRNA-Target Expression Profile | |||||||
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MiRNA-Target Expression Profile (TCGA) | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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107 hsa-miR-605-5p Target Genes:
Functional analysis:
ID | Target | Description | Validation methods | |||||||||
Strong evidence | Less strong evidence | |||||||||||
MIRT001230 | SEC24D | SEC24 homolog D, COPII coat complex component | 3 | 1 | ||||||||
MIRT016155 | TP53 | tumor protein p53 | 2 | 1 | ||||||||
MIRT016156 | TCEAL1 | transcription elongation factor A like 1 | 1 | 1 | ||||||||
MIRT016157 | MDM2 | MDM2 proto-oncogene | 2 | 1 | ||||||||
MIRT040476 | YBX1 | Y-box binding protein 1 | 1 | 1 | ||||||||
MIRT040477 | TMEM64 | transmembrane protein 64 | 1 | 1 | ||||||||
MIRT040478 | KDM5C | lysine demethylase 5C | 1 | 1 | ||||||||
MIRT040479 | TRAF4 | TNF receptor associated factor 4 | 1 | 1 | ||||||||
MIRT040480 | DRG1 | developmentally regulated GTP binding protein 1 | 1 | 1 | ||||||||
MIRT040481 | BCL9 | B-cell CLL/lymphoma 9 | 1 | 1 | ||||||||
MIRT055125 | SCD | stearoyl-CoA desaturase | 2 | 2 | ||||||||
MIRT057521 | CEP55 | centrosomal protein 55 | 2 | 2 | ||||||||
MIRT081129 | LDLR | low density lipoprotein receptor | 2 | 6 | ||||||||
MIRT096817 | ZSWIM6 | zinc finger SWIM-type containing 6 | 2 | 4 | ||||||||
MIRT100961 | CENPQ | centromere protein Q | 2 | 4 | ||||||||
MIRT263338 | ANAPC16 | anaphase promoting complex subunit 16 | 2 | 2 | ||||||||
MIRT274710 | CPSF6 | cleavage and polyadenylation specific factor 6 | 2 | 2 | ||||||||
MIRT311193 | ANKRD33B | ankyrin repeat domain 33B | 2 | 2 | ||||||||
MIRT360127 | DEK | DEK proto-oncogene | 2 | 2 | ||||||||
MIRT438269 | PSMD10 | proteasome 26S subunit, non-ATPase 10 | 2 | 1 | ||||||||
MIRT442464 | SLC25A13 | solute carrier family 25 member 13 | 2 | 2 | ||||||||
MIRT446110 | TSC22D2 | TSC22 domain family member 2 | 2 | 2 | ||||||||
MIRT463119 | ZNF507 | zinc finger protein 507 | 2 | 2 | ||||||||
MIRT470566 | POU2F1 | POU class 2 homeobox 1 | 2 | 2 | ||||||||
MIRT475059 | IVNS1ABP | influenza virus NS1A binding protein | 2 | 6 | ||||||||
MIRT482538 | ACTB | actin beta | 2 | 4 | ||||||||
MIRT494136 | DCAF7 | DDB1 and CUL4 associated factor 7 | 2 | 6 | ||||||||
MIRT495209 | EDN3 | endothelin 3 | 2 | 2 | ||||||||
MIRT495235 | LONRF3 | LON peptidase N-terminal domain and ring finger 3 | 2 | 2 | ||||||||
MIRT496762 | MANBAL | mannosidase beta like | 2 | 2 | ||||||||
MIRT498885 | ZNF12 | zinc finger protein 12 | 2 | 10 | ||||||||
MIRT499280 | NBPF11 | NBPF member 11 | 2 | 2 | ||||||||
MIRT507063 | H3F3B | H3 histone family member 3B | 2 | 2 | ||||||||
MIRT508352 | HES7 | hes family bHLH transcription factor 7 | 2 | 8 | ||||||||
MIRT510740 | SMC1A | structural maintenance of chromosomes 1A | 2 | 6 | ||||||||
MIRT519872 | ZFP62 | ZFP62 zinc finger protein | 2 | 4 | ||||||||
MIRT521272 | RTN4 | reticulon 4 | 2 | 4 | ||||||||
MIRT522324 | NFIB | nuclear factor I B | 2 | 6 | ||||||||
MIRT525011 | ACTN4 | actinin alpha 4 | 2 | 6 | ||||||||
MIRT526608 | AASDH | aminoadipate-semialdehyde dehydrogenase | 2 | 4 | ||||||||
MIRT529043 | ARL9 | ADP ribosylation factor like GTPase 9 | 2 | 2 | ||||||||
MIRT529545 | ZNF678 | zinc finger protein 678 | 2 | 2 | ||||||||
MIRT532500 | HOXA13 | homeobox A13 | 2 | 2 | ||||||||
MIRT532599 | SIX4 | SIX homeobox 4 | 2 | 2 | ||||||||
MIRT534044 | STK4 | serine/threonine kinase 4 | 2 | 2 | ||||||||
MIRT534087 | SPPL3 | signal peptide peptidase like 3 | 2 | 2 | ||||||||
MIRT534249 | SLC16A1 | solute carrier family 16 member 1 | 2 | 2 | ||||||||
MIRT534286 | SLC12A7 | solute carrier family 12 member 7 | 2 | 2 | ||||||||
MIRT534555 | RUNX1 | runt related transcription factor 1 | 2 | 2 | ||||||||
MIRT536765 | HOXB2 | homeobox B2 | 2 | 2 | ||||||||
MIRT537227 | GAN | gigaxonin | 2 | 2 | ||||||||
MIRT551105 | TTC8 | tetratricopeptide repeat domain 8 | 2 | 2 | ||||||||
MIRT552247 | DUSP3 | dual specificity phosphatase 3 | 2 | 2 | ||||||||
MIRT554361 | SFXN5 | sideroflexin 5 | 2 | 2 | ||||||||
MIRT557402 | H3F3C | H3 histone family member 3C | 2 | 2 | ||||||||
MIRT559116 | C16orf52 | chromosome 16 open reading frame 52 | 2 | 2 | ||||||||
MIRT560494 | BUB3 | BUB3, mitotic checkpoint protein | 2 | 2 | ||||||||
MIRT562296 | GLO1 | glyoxalase I | 2 | 2 | ||||||||
MIRT562597 | CAPZA2 | capping actin protein of muscle Z-line alpha subunit 2 | 2 | 2 | ||||||||
MIRT563857 | ALYREF | Aly/REF export factor | 2 | 4 | ||||||||
MIRT565665 | SIX1 | SIX homeobox 1 | 2 | 2 | ||||||||
MIRT568253 | BTF3L4 | basic transcription factor 3 like 4 | 2 | 2 | ||||||||
MIRT609593 | GPM6B | glycoprotein M6B | 2 | 2 | ||||||||
MIRT611552 | GGT6 | gamma-glutamyltransferase 6 | 2 | 2 | ||||||||
MIRT613451 | CYLD | CYLD lysine 63 deubiquitinase | 2 | 2 | ||||||||
MIRT615516 | PRRC2A | proline rich coiled-coil 2A | 2 | 2 | ||||||||
MIRT617766 | C17orf105 | chromosome 17 open reading frame 105 | 2 | 2 | ||||||||
MIRT619134 | MCOLN3 | mucolipin 3 | 2 | 2 | ||||||||
MIRT621365 | CAP2 | cyclase associated actin cytoskeleton regulatory protein 2 | 2 | 2 | ||||||||
MIRT625804 | MDC1 | mediator of DNA damage checkpoint 1 | 2 | 2 | ||||||||
MIRT626954 | PRDM2 | PR/SET domain 2 | 2 | 2 | ||||||||
MIRT627716 | RCAN1 | regulator of calcineurin 1 | 2 | 2 | ||||||||
MIRT628069 | KCNJ13 | potassium voltage-gated channel subfamily J member 13 | 2 | 2 | ||||||||
MIRT630451 | GTPBP8 | GTP binding protein 8 (putative) | 2 | 2 | ||||||||
MIRT635533 | ELMOD2 | ELMO domain containing 2 | 2 | 2 | ||||||||
MIRT636206 | SULF2 | sulfatase 2 | 2 | 2 | ||||||||
MIRT638763 | EPHA4 | EPH receptor A4 | 2 | 2 | ||||||||
MIRT640324 | STAT1 | signal transducer and activator of transcription 1 | 2 | 2 | ||||||||
MIRT644548 | SPOP | speckle type BTB/POZ protein | 2 | 2 | ||||||||
MIRT645114 | TMX2 | thioredoxin related transmembrane protein 2 | 2 | 2 | ||||||||
MIRT647778 | NANOS1 | nanos C2HC-type zinc finger 1 | 2 | 2 | ||||||||
MIRT650112 | ZCCHC9 | zinc finger CCHC-type containing 9 | 2 | 2 | ||||||||
MIRT650136 | ABCB7 | ATP binding cassette subfamily B member 7 | 2 | 2 | ||||||||
MIRT650310 | SLC35E2 | solute carrier family 35 member E2 | 2 | 2 | ||||||||
MIRT650930 | ST6GALNAC1 | ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 | 2 | 2 | ||||||||
MIRT651018 | ZNF740 | zinc finger protein 740 | 2 | 2 | ||||||||
MIRT653541 | SLC38A9 | solute carrier family 38 member 9 | 2 | 2 | ||||||||
MIRT655752 | NR2C2 | nuclear receptor subfamily 2 group C member 2 | 2 | 2 | ||||||||
MIRT656908 | KIAA1958 | KIAA1958 | 2 | 2 | ||||||||
MIRT657854 | GJD3 | gap junction protein delta 3 | 2 | 2 | ||||||||
MIRT658215 | FBXO21 | F-box protein 21 | 2 | 2 | ||||||||
MIRT659884 | CAPN7 | calpain 7 | 2 | 2 | ||||||||
MIRT659922 | CACNA1E | calcium voltage-gated channel subunit alpha1 E | 2 | 2 | ||||||||
MIRT660055 | C12orf5 | TP53 induced glycolysis regulatory phosphatase | 1 | 1 | ||||||||
MIRT664616 | LIMD1 | LIM domains containing 1 | 2 | 2 | ||||||||
MIRT665392 | WEE1 | WEE1 G2 checkpoint kinase | 2 | 2 | ||||||||
MIRT667887 | IP6K1 | inositol hexakisphosphate kinase 1 | 2 | 2 | ||||||||
MIRT669018 | CHORDC1 | cysteine and histidine rich domain containing 1 | 2 | 2 | ||||||||
MIRT688419 | DUSP2 | dual specificity phosphatase 2 | 2 | 2 | ||||||||
MIRT691888 | GXYLT2 | glucoside xylosyltransferase 2 | 2 | 2 | ||||||||
MIRT709530 | GEN1 | GEN1, Holliday junction 5' flap endonuclease | 2 | 2 | ||||||||
MIRT711013 | ABCD2 | ATP binding cassette subfamily D member 2 | 2 | 2 | ||||||||
MIRT714731 | CENPH | centromere protein H | 2 | 2 | ||||||||
MIRT719897 | PTGIS | prostaglandin I2 synthase | 2 | 2 | ||||||||
MIRT725028 | CX3CL1 | C-X3-C motif chemokine ligand 1 | 2 | 2 | ||||||||
MIRT734348 | P2RY12 | purinergic receptor P2Y12 | 3 | 0 | ||||||||
MIRT736719 | TNFAIP3 | TNF alpha induced protein 3 | 3 | 0 |
miRNA-Drug Associations | ||||||||||||||||||
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miRNA-Drug Resistance Associations | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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