miRTarBase - #MIRT059267


—
pre-miRNA Information
pre-miRNA hsa-mir-6511a-1   
Genomic Coordinates chr16: 14925937 - 14926003
Description Homo sapiens miR-6511-1 stem-loop
Comment None
RNA Secondary Structure
pre-miRNA hsa-mir-6511a-2   
Genomic Coordinates chr16: 16324588 - 16324654
Description Homo sapiens miR-6511a-2 stem-loop
Comment None
RNA Secondary Structure
pre-miRNA hsa-mir-6511a-3   
Genomic Coordinates chr16: 16368876 - 16368942
Description Homo sapiens miR-6511a-3 stem-loop
Comment None
RNA Secondary Structure
pre-miRNA hsa-mir-6511a-4   
Genomic Coordinates chr16: 18344013 - 18344079
Description Homo sapiens miR-6511a-4 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-6511a-3p
Sequence 44| CCUCACCAUCCCUUCUGCCUGC |65
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1431539827 1 dbSNP
rs1283143052 1 dbSNP
rs1490854154 2 dbSNP
rs1429422271 2 dbSNP
rs1357267539 3 dbSNP
rs1203305934 4 dbSNP
rs1467143402 4 dbSNP
rs1175056874 7 dbSNP
rs1384623716 8 dbSNP
rs1333223665 8 dbSNP
rs1168832367 9 dbSNP
rs3871561 9 dbSNP
rs1334564010 9 dbSNP
rs1176278657 9 dbSNP
rs1420052973 10 dbSNP
rs1404012200 10 dbSNP
rs1427021548 12 dbSNP
rs1179482082 12 dbSNP
rs1479752195 12 dbSNP
rs1472016809 14 dbSNP
rs1184349311 15 dbSNP
rs1362873619 16 dbSNP
rs1367067761 17 dbSNP
rs1395473131 17 dbSNP
rs1426225034 17 dbSNP
rs1420386504 18 dbSNP
rs1313509970 18 dbSNP
rs1187526305 18 dbSNP
rs1444631179 19 dbSNP
rs1342555242 20 dbSNP
rs1225473458 22 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol CELF1   
Synonyms BRUNOL2, CUG-BP, CUGBP, CUGBP1, EDEN-BP, NAB50, NAPOR, hNab50
Description CUGBP Elav-like family member 1
Transcript NM_001172640   
Other Transcripts NM_001025596 , NM_001172639 , NM_006560 , NM_198700   
Expression
Putative miRNA Targets on CELF1
3'UTR of CELF1
(miRNA target sites are highlighted)		 
>CELF1|NM_001172640|3'UTR
   1 GCGTGCTCCCCTCTGAGACTGGAGTGAGAGGGTCTTCTGGCACAGCTTGCCCTGAAGACTCGGCTACTGCCTTCTGTGGG
  81 AGTTTCGCTTCGTACAGAGGACAAGTTTGTGCTTTGGTTTCCAGTGTTTTACTTTGGAGTTTAGGTGCCATATCCTGAGG
 161 TTTTTTTTGTTTTTGTTTTTGTTTCTCCTTTATTTAAAGTTTGCTGTGTTTGTAACCAGTGTGTGTTGAGAAGGACCAAC
 241 ACCAAACCACCCTGGGGAAGGGGGACAGGGAAACATTTAACACAGACGATGATCAGGATTTGCCCCAAACCACCCCAAGA
 321 GAGAGGACTGAGTGGAACAAAAAAGTGACCCCCAGAACCTCTCTTAGTGTGAGGGTGGGTAGAATGAGAACTGACACCTG
 401 GGAGCTGTGGGGAGCAGAGCGGCTTTGGGGAAGAGTGGAGTGACTAGACACCTAATGCCCTGGCAGCTGGAGACTCAAAC
 481 TCCTGTACAGCTACCTTCTGGGAAATAGTTTTTGACACCTATTTTTCAGATTCTTGTCCGGAATTTCTGCTGCTCTTTTC
 561 AAAAAAGGGCATTAACAATTCTCTGGAAATAAAGCACCTGTTAGCCTGACATATGCAAAAAGCAGGGCGGCATCACCCAT
 641 TACGAGCTCCCCCAGCCAGCAGTCAGTATTGGATTGGCCTTGCCTGGCTGGTGGCAGTTTGGGAGAAACAGCCAAAGAGG
 721 TTAGTTTATTTCAACACCAAATTAGACCATGGCCCATTTCCAACGGGTCTCTTTAAAGGCCTCTATGGAATACATTGCCT
 801 GGTTTCCTTCTTTGCAGTTCACCACAGCAAGGAATGTCACCTCCATCCCAAGCCACCATTTTCTCATGAAGGCAAATCCA
 881 AGAAGGGCTTGCAGTTCTTGCTGAAGGGGGTACCATTTGTGGGCAGAGTGATCAATACCATCTAGTTGGGGGAGGAGGAG
 961 CTTATTTCTTGGTGTACTTGAATCAGAAGGTCCCTGCAAGCCAGTATGCTTCATTTGCCAGTGGCCAGAAATTCTCCCTT
1041 GCCTCCTTGATTGAGGTGTCCCAGATGTAGTATTCCCACAGGGGTCTGGCAGGCCCCTCCTGTAACCACTCCAGTCACAT
1121 TTTCTGCTCTTGAGGCAGAGGTGACATCAGGACGTTTACAGCCTCCACATGAATTGAGTGTTCATTTACCTCAGTATTAC
1201 CGTGTTCATTTTTGTCCTCGTGCTACAGTTAGCTCCCTGCCGCCTCTTGCAGGTCTTACTTCAGCTCTTGCCTGTGACCC
1281 ACACAGCTTCTGGGCTCTGCCTCTGCTCTAAGAAGTGCTGTGGGGGTAGAGAACCAGGAAGGACATGCTGTTGGGAATGT
1361 ACACCTGGGCAGAGGTGGCCCTGTTAAGATGTGACTGTAGCCACAGCCAGGGATGGGATCCCTGGGTCTCTGGAATCTGA
1441 AACCTCAACAAATACCAGTCTTGACCCCTAGCAGCAGAGATAAGAATAAAGGGGTTGGTTTGCTATTAAGTCAGATGGGG
1521 GCTCTCTCCTTGTCATGCTGTCCCTGTGGGTAACAGACAGGGATTGACCATCTTACTGTTGTACAGGTAGCTGGTGGTGT
1601 TGGATTATCCCATTGAAGCTGGGACAGCTGTTCCTTTCTCATAGTGATAACTTGGGTCTGTTGTCCTCTAAGGAACGTGA
1681 AACATACACTTCTTAAGCTGAACCACGTAAACTTGAAATTCTGCGCACTGGGAGAAATGTGTCCTGTGTTTCAAAGGATA
1761 AAACTGTTCTAAAGGCTTCCAGGGTCATGATGGGATTTTTTAAATAAATGCAAAAAATAAAAATAAAAAAGAAAAAAGAA
1841 AACAAAAAAAAAAAAGAAAAAAATGCTAGGTTGGGGAGGCGCTGTTCTGAATCCCAACCGGCTGGAACCAAGAATGTCGT
1921 TTCTATTTTTATAGAAGTTTTATACAGCTCCGGGGTGGAGAATATTTATTACCTAAATTATATCTCTGGAAAAGGCCAGG
2001 ATTTTGTAGAATCCAGAATGTGATTGTTATACACACAGGGTGCTGTGTATGATTGAAACTACTGACTTTCTGTGGCCCGT
2081 TTGCAGCCCAGCTAACCTGCCCAAGGGGAAGGTGTTAATGCTGTGAATTGGCAGAGGAGAGAGCTGTGCTCCATAGGGTG
2161 CTGCCGGTGCTGTGCTCCCTAGCCTTCTGTTCTGTCTTCCTCCTTAGCCAGAACGCCACTCCCTTCCCACATCCCCTTCT
2241 TCTCTCCGCCTTCCCCCATCTCACCATTATTTGTCCATGGATTTGTCCTGGGCTCTGGGACCTTATGAAACCCCTTTCCT
2321 AATGACATAAGAGGCCAAGGTGCAATCCACCCACCTTTGATACCAGACCCTGAGGGCTTCATACCTGCTGATGGGTTTTC
2401 TTTTCTAAAAGGAATGCTCGCCCCAGCAGGGTCCTGGGCTGCTTGAGCAGCCAGCTGGTGAGACCATGCACTTCTCTGTT
2481 CTCTCCTCCCCCTGCCCAGTGAGTTAGCACAGCAGTAGCACTGCCCTTGAGCACAGTTCTTTCCCCAGGCCAAAGATGGT
2561 TTTGTGAAGAAGCTGCTCCCCTACAAGTCTCACGTGTGAAAGGGCTCAGCTCAGAGTGGAGACTCGCTGTCAAGTCTTAA
2641 GCAATCCTTTTCTGTTGTGTGAAGGTTTCACTTACAATGTGTTTTCTGCTGTAGTTTTGTTTCTTACTTGGGTTACATCA
2721 TGAAATTGATTTGCCTTGAATGCAGCCAGACCACTGTCTCCTGGGTTCCCCTTGAGTGGCCAGGGCCTGGATGGAAGCTA
2801 AGAGCTTGGATTTCTGGGAACAAAGGGCCATCCCCATAAGATTGAGCAGAAATTCTGGTCCTCTTCCCTGAAAAATTTTC
2881 CCCACCCCAGCCAGCATCTTCTGCTTCCCCTTGGGTTGTGACCAGGGAGTGGGGAGAGAGGCTGAGGCTCTGCTCCCCTG
2961 GAGACCTTCTCTTAGGAGTTGGGTGCTTCATGGAAAATCCAAGCCTTAGGTTCCCTTCTGTCTCTGGCAATTAGATGTGT
3041 TCTTGGTGTCCTCCATGTCCTTTTTGACTTTTCCCTGTGTCCATTGTTAGCATGTGCAAAAGTTCCCTGTCATTACCCAA
3121 CCCCTGCCCGCCCACCTCATTTCAGGGCTGTACACACAGTGAGTGTTCCTGTTCTCTCTCTCTTTGTTTGGATGTATTGC
3201 TCTGTGTAACTCAGTGGGTCTCCCTCTTTCTGGTTTGTTTTTTTTTCTAGATTCCTGCCGTTTGTTCATCGTTGTGCCTA
3281 AAGCATGTCGATGTGGCGTCAAGTACATCGTCCAAATCCCTGTCTCTTCAGCTTCTCTGATGCTTGAACTCTCACCTTTG
3361 ACCTTGTGTTGACCTTTGATGCTGATGTGTATTTTTATTATGTTTGTTTCTTTCTTCGTTTTTTTTTCTTTTTTTCTTTC
3441 CTTTTTTTTTCCTTTTGTGCTGCCAAATTGGTTTTGCTAGAACGACTGCTGAAGGGGAAATATTTAAACTTGCATTTGAA
3521 TATAAAAAAAATCTATTTTTCTAGAACTTCATAAGATAACCACTTGATTTTGTGATTCCAATTCTTTGTAATTGTCTTCA
3601 GAGCAGCCCTACTAGCACATACCGCGTGGTGTTTGTATTTCTGTGAACACACAGCCAGTCCGTTTCTAGGCTTTGTTTCT
3681 CTGTGTGCTTAGTTTTAAAGACAACTTTGAAGTAAACAATGAAATAAAAGATGTCACTAAAACCTCTGAGGCTCCTGAGC
3761 ACATTTTGCTGATACAGTCTGTGGGGCTTGAGGAGACCGCATGTATTGTTCTTTCTTTTGTTTTTCTTCTGAGTTCTCAA
3841 CTGCGGAGAGCACCTGAACCCCCTTTCCTTTTTGACCGCAGGCTGCACTTTGGGCCCCAGCCAGCCCTTTTTCTTTTTCT
3921 TTTTCTTTTGTGGTTCTTCCCTGGAGCGACTCTGGGGAGTCCTGGATATCCCGCCTGCCCCTTCCCCTCAGCCCCATGCT
4001 TGTTCCAACAGTCTCCACAGCAAAATGTGATGCTTTGATTTTTTTGTTGTTGTTTTTGTTTTTGTATTGTTTTTGTGTTT
4081 TTGTTTTGAATTTTTTCCTTTCCTACTAAGATTATGCCCAGAAAAAAGTTTTGCATGTTTCCTGCTGTTTCTTCACACCT
4161 TCGTATATATCACCTTCACCTCTCTGTTTTCTATAGTTTGTGCAAAAACTGATCGATTTAAAAGGGTTTCAAAGAAGCTG
4241 TTTTAAATTGTTGTAGGGTTGATTATTTTTTTCAAGATTGTATTGTTTAATTTTGAAGTGGCAACTTTCTCCTCTATTGC
4321 CCTTAGAGCGTTTGCCTGTGCACTTAGACTGTCACTTCGTGTGGCCTCCAGGTCTTACCGGGGCTTCCGGGAGGCTGGCT
4401 GCTTTGCTCAGAGAGGGTGGGAAGGGGGCCTGGAGAGACACGAGAAGCAGAGGTAGAGCCTAGAAGGTGGCAGCAGGTGG
4481 GTAAGAGGCTTATTTAGCACATTAGGGGCAGTGAGCACCTGGAGGAAGGAGGGCGCTCCCAATCACCCGTAGGAGGCCAT
4561 CTGCACACCAAGCGGCAATTCACCTGCTGGCGCTTTTCCTAGGTGACAAGCACAATACTACAGTCTTCACACTGTTTACA
4641 GCCCTGGGCACCAGCCACCCGGCACTGGCTCTTCATCACAGCTCTGCTCTTGCTTAGCTAGTGGGGTGGGGGAAAGGGCA
4721 GGGATTTGTTTTTTTAATTGGGTGGAGAGCCAAACAGCTACTGTCCCTGGGTGCCAAGCAAGCCAGTTTTTTGGTTCCCT
4801 GAGGGAAACTGACCCTCCTCTCTTGTGGCACCATCCAGCCTCAGGGTCTTGGAGACTTGAGTAAGAATGTGAGTGGAGGG
4881 GGAGAGGTGAGGAGAGGAGCACAGGGTGGATCTGTGGAGGGAAGAGGTTACAGGGGGAGGAGCTGATGATAGATCCCACC
4961 CAGACTTAAGCTGCTGGTGGGTGGGTGAGCTGGGAAGTAGGACTGTCCAGGGAAGGGTGGAGAGATGTAGCTAGGGGCTG
5041 GGGAGGGGGAGGTGGAAGCGCTATTGAGCATCCTCCACACCAAGGTTGATGAAGGAAGGGATCCCAGCAGGGTTTCTGCT
5121 CTGGGGCTGGCAGGTTGCCTGGTATTATGCCCAAGGCCGCTCTGCCTGGGGGAAAGGGCAGCCAGGCAGAGGCCCAGTGT
5201 CTGGTAGGCTGCTGAATTTCCTGGAAGGGGTGATTGGATGGAAAGAGGCCAGAAACCCCAGCCTGAGAGACTGCTGTGCA
5281 CCCCACAGTCTGACTGCACAGAGCCGCCTCTGTTGGCAGGAGGCACTGAGGCTCCCCTTCCTGTGTATTGAGAAGCAGTG
5361 TTTGCCAATATATTTTGCTTTCAATTCCAAGAGGAGCTCTGGGAAAACCTGTGGATAAAACCAAATGCCAAATGTTGGAC
5441 GTTGTTTCCTTTTCCTTTTCTCTCTCTGATTGTTTTAATTGTTCTGTGGTGGTTTTAATGGATTTGAGACCCTGGAGCGG
5521 CAGCTGCCTTTCTGATTTCCAGCTGCTTTTTGTGAATAATTTAAAAAGAAAAAAAAAAAGAAACTTTACATTTTGGAGAC
5601 AAACCTGTGTGAGTTTTTTATTGGTACAAACGTTGTATTTAACACTAGGGGTTTTGTACAGTTTTTTGCCTTTTCTACTA
5681 GAAAACAATGTAAAGTGATTTCACAATGTGAAGAGAAAAAAAAATTGCCACTATGACCAAACGCACAGTCTGTTCTGCAG
5761 CAACAACGGGATTCAATCAACTCAGTCGTGATTCAGCCGTAGAAATGCTTTTCCTTTATCTTGTTTGAGCTTTTCCTTTC
5841 TTTCCTGTTTTGATTTGCAAAAGAAAATGTCTTTTTTGTGTGAACTTGTGTTGTACTCTGTAGAAAATTATGGATTTTAC
5921 TTTAATGGTTTAAAAAAAGGCAAGGAGAGCCCTCGTCGCTTTTCTTACCTAATCACAGAGTTTGTGTAGTGAATTTAAAA
6001 AGAAAAAAAAATTGTTATAAGTTTGGAGCAAGGGAGTATGTGTTTCAAAGGAATCTCCTTCCTTTTTTTGTGTGTTTTTC
6081 CTTTTGTCCCAATGGGGAACCTAAATCTGTTTTAATTGCACAGACACATGGACAAAAAGTCATTTTGTATCTGCCAAGTG
6161 TGGTACCTTCCTTTGTTTATTTGCTATTAAACTGTTTGAGAAGAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' cguccgUCUUC--CCUACCACUCc 5'
                || ||   | ||||||| 
Target 5' tgcttgAGCAGCCAGCTGGTGAGa 3'
 2440 - 2463 146.00 -15.80
2 
miRNA  3' cgUCCGUCUUC-CCUACCACUCc 5'
            || |  |||  | |||||:| 
Target 5' ccAGACTTAAGCTGCTGGTGGGt 3'
 4960 - 4982 136.00 -12.90
3 
miRNA  3' cgUCCGUCUUCCCUACCACUCc 5'
            |||  |||||| ||| ||| 
Target 5' ccAGG--GAAGGG-TGGAGAGa 3'
 5007 - 5025 135.00 -20.70
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN13326255 2 COSMIC
COSN13326254 3 COSMIC
COSN32052841 50 COSMIC
COSN26970270 71 COSMIC
COSN26970271 108 COSMIC
COSN8641706 145 COSMIC
COSN26970272 149 COSMIC
COSN8681778 159 COSMIC
COSN1133605 187 COSMIC
COSN17423836 609 COSMIC
COSN14618939 759 COSMIC
COSN5306354 796 COSMIC
COSN22274972 1007 COSMIC
COSN29438700 1353 COSMIC
COSN4897349 2277 COSMIC
COSN8280506 2302 COSMIC
COSN25132171 2707 COSMIC
COSN29957166 2740 COSMIC
COSN5912758 2834 COSMIC
COSN5912757 2848 COSMIC
COSN23820688 3154 COSMIC
COSN21509732 3191 COSMIC
COSN5912756 3218 COSMIC
COSN29517682 3325 COSMIC
COSN5261686 3378 COSMIC
COSN31559511 3386 COSMIC
COSN23819451 3454 COSMIC
COSN31516318 3498 COSMIC
COSN31569147 3506 COSMIC
COSN30543917 3539 COSMIC
COSN31483824 3579 COSMIC
COSN31607284 3627 COSMIC
COSN31536123 3719 COSMIC
COSN30539140 3733 COSMIC
COSN30539148 3809 COSMIC
COSN5912755 4369 COSMIC
COSN24989112 4730 COSMIC
COSN18930259 5031 COSMIC
COSN16125083 5893 COSMIC
rs555328608 5667 GWAS
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1261256325 1 dbSNP
rs760769305 2 dbSNP
rs376118578 3 dbSNP
rs1275465163 6 dbSNP
rs1438919197 7 dbSNP
rs368193470 9 dbSNP
rs745661116 13 dbSNP
rs778722370 17 dbSNP
rs566258688 20 dbSNP
rs1335390679 24 dbSNP
rs1360560579 27 dbSNP
rs1343176581 30 dbSNP
rs749204728 32 dbSNP
rs1429431069 34 dbSNP
rs1056035284 37 dbSNP
rs1173852694 44 dbSNP
rs892269368 46 dbSNP
rs1413700823 47 dbSNP
rs570997512 55 dbSNP
rs201800783 62 dbSNP
rs1051092703 70 dbSNP
rs547680359 71 dbSNP
rs932599044 74 dbSNP
rs1316645457 77 dbSNP
rs1360368959 81 dbSNP
rs1234501607 89 dbSNP
rs921357023 97 dbSNP
rs981104057 108 dbSNP
rs1485002206 111 dbSNP
rs1208073727 115 dbSNP
rs929677376 119 dbSNP
rs781259418 120 dbSNP
rs533847385 122 dbSNP
rs747027562 123 dbSNP
rs139860706 124 dbSNP
rs1405359390 139 dbSNP
rs1337275872 142 dbSNP
rs548207347 150 dbSNP
rs1176608556 152 dbSNP
rs1409083120 155 dbSNP
rs1018559698 157 dbSNP
rs780142833 164 dbSNP
rs187136014 166 dbSNP
rs960940091 173 dbSNP
rs1296657673 174 dbSNP
rs1411758600 174 dbSNP
rs781014720 174 dbSNP
rs1372963827 175 dbSNP
rs1220151799 179 dbSNP
rs758518592 180 dbSNP
rs1030257243 182 dbSNP
rs1234152982 192 dbSNP
rs181717309 199 dbSNP
rs1342178479 202 dbSNP
rs1206077921 221 dbSNP
rs903254713 222 dbSNP
rs1230815705 223 dbSNP
rs1191992197 226 dbSNP
rs1480128747 231 dbSNP
rs1161067155 246 dbSNP
rs1191529058 249 dbSNP
rs190061716 249 dbSNP
rs1012101752 251 dbSNP
rs1365862927 252 dbSNP
rs1183579172 257 dbSNP
rs1390775099 260 dbSNP
rs1482977790 263 dbSNP
rs1022062620 265 dbSNP
rs1168481668 267 dbSNP
rs989615251 269 dbSNP
rs770842168 273 dbSNP
rs893295019 275 dbSNP
rs777830819 287 dbSNP
rs937566860 291 dbSNP
rs1251498389 296 dbSNP
rs907461069 297 dbSNP
rs1045396017 299 dbSNP
rs768122915 300 dbSNP
rs373367995 302 dbSNP
rs918279144 304 dbSNP
rs561664058 308 dbSNP
rs1368053293 313 dbSNP
rs1008858071 315 dbSNP
rs1352596563 322 dbSNP
rs1270330803 323 dbSNP
rs1306432649 329 dbSNP
rs532467563 333 dbSNP
rs890379996 334 dbSNP
rs560246454 335 dbSNP
rs1466963551 336 dbSNP
rs540062715 349 dbSNP
rs941148276 352 dbSNP
rs996864362 359 dbSNP
rs1476381454 367 dbSNP
rs1348488126 371 dbSNP
rs911019223 375 dbSNP
rs1405075813 376 dbSNP
rs985705377 390 dbSNP
rs1038477314 397 dbSNP
rs955290495 405 dbSNP
rs1179092837 407 dbSNP
rs1348773623 417 dbSNP
rs1029554657 423 dbSNP
rs887319484 427 dbSNP
rs978004756 431 dbSNP
rs967339620 434 dbSNP
rs1160290476 435 dbSNP
rs1020273607 437 dbSNP
rs939484087 438 dbSNP
rs928228554 440 dbSNP
rs1011657385 457 dbSNP
rs980964447 461 dbSNP
rs374413603 462 dbSNP
rs957685807 466 dbSNP
rs1448554194 467 dbSNP
rs989276299 478 dbSNP
rs956658222 487 dbSNP
rs184028099 497 dbSNP
rs1002122444 505 dbSNP
rs1415914932 507 dbSNP
rs987309753 508 dbSNP
rs1219680462 509 dbSNP
rs954498119 515 dbSNP
rs1028934373 520 dbSNP
rs996077118 524 dbSNP
rs899860965 525 dbSNP
rs1414836228 536 dbSNP
rs562087538 537 dbSNP
rs1232260889 538 dbSNP
rs964059076 538 dbSNP
rs541806318 540 dbSNP
rs1288593974 555 dbSNP
rs1045995901 557 dbSNP
rs1352506683 559 dbSNP
rs994449565 561 dbSNP
rs1207937423 564 dbSNP
rs1283469929 566 dbSNP
rs1326782119 568 dbSNP
rs896823623 570 dbSNP
rs1038448831 581 dbSNP
rs1264987623 584 dbSNP
rs1274612542 589 dbSNP
rs1223992101 591 dbSNP
rs1366332485 594 dbSNP
rs1272507465 600 dbSNP
rs1255428636 607 dbSNP
rs1432476689 611 dbSNP
rs1183079627 615 dbSNP
rs1365771959 617 dbSNP
rs1468908858 619 dbSNP
rs1326717436 620 dbSNP
rs181084588 627 dbSNP
rs941086457 628 dbSNP
rs887196183 635 dbSNP
rs1373029409 645 dbSNP
rs910977715 647 dbSNP
rs545107438 655 dbSNP
rs1049559829 657 dbSNP
rs1439710966 658 dbSNP
rs1179234805 661 dbSNP
rs1345481389 662 dbSNP
rs189229723 664 dbSNP
rs922469802 671 dbSNP
rs1424553647 696 dbSNP
rs977968970 700 dbSNP
rs1278101101 702 dbSNP
rs879383300 704 dbSNP
rs1347166533 706 dbSNP
rs1189486154 712 dbSNP
rs1206027998 716 dbSNP
rs546041428 716 dbSNP
rs913194183 717 dbSNP
rs1181393154 718 dbSNP
rs1247620485 723 dbSNP
rs577479545 730 dbSNP
rs1455859915 731 dbSNP
rs948294631 732 dbSNP
rs914951513 740 dbSNP
rs554337760 745 dbSNP
rs957447772 746 dbSNP
rs934978065 775 dbSNP
rs1407806965 788 dbSNP
rs923698982 794 dbSNP
rs1371370386 807 dbSNP
rs1442845483 809 dbSNP
rs1210736129 815 dbSNP
rs1034866402 820 dbSNP
rs1311477958 822 dbSNP
rs765966084 839 dbSNP
rs151250368 841 dbSNP
rs1337572050 848 dbSNP
rs3508 851 dbSNP
rs1215885638 853 dbSNP
rs142431972 857 dbSNP
rs921750229 859 dbSNP
rs1192226204 871 dbSNP
rs974692758 873 dbSNP
rs537953599 889 dbSNP
rs963625184 891 dbSNP
rs994383986 894 dbSNP
rs897419281 901 dbSNP
rs1374254544 903 dbSNP
rs1474141250 913 dbSNP
rs1296479180 919 dbSNP
rs34258212 921 dbSNP
rs1038011815 923 dbSNP
rs1005650786 926 dbSNP
rs1462812343 927 dbSNP
rs568839507 928 dbSNP
rs889486550 929 dbSNP
rs1350540156 936 dbSNP
rs1049931891 939 dbSNP
rs552203247 940 dbSNP
rs1324701921 946 dbSNP
rs1226863829 947 dbSNP
rs1294134177 953 dbSNP
rs770393256 963 dbSNP
rs1449410218 969 dbSNP
rs1359150190 976 dbSNP
rs532394202 994 dbSNP
rs758429691 999 dbSNP
rs1272891674 1009 dbSNP
rs1042203785 1016 dbSNP
rs945258459 1023 dbSNP
rs566693824 1024 dbSNP
rs915154291 1049 dbSNP
rs1260273257 1053 dbSNP
rs990143235 1065 dbSNP
rs906743160 1070 dbSNP
rs957583084 1078 dbSNP
rs1244762394 1080 dbSNP
rs927344494 1082 dbSNP
rs1045205972 1090 dbSNP
rs1012377115 1099 dbSNP
rs894057517 1103 dbSNP
rs1206510296 1109 dbSNP
rs546769116 1116 dbSNP
rs980174527 1134 dbSNP
rs1454136523 1143 dbSNP
rs1290545117 1152 dbSNP
rs971474939 1155 dbSNP
rs1381688841 1167 dbSNP
rs1313613971 1170 dbSNP
rs1357467789 1171 dbSNP
rs1231641341 1172 dbSNP
rs777061615 1190 dbSNP
rs1317833169 1191 dbSNP
rs935009474 1200 dbSNP
rs1259479871 1205 dbSNP
rs1485848754 1215 dbSNP
rs1212257290 1216 dbSNP
rs1273229278 1220 dbSNP
rs1024446492 1225 dbSNP
rs775169126 1233 dbSNP
rs923584163 1235 dbSNP
rs1256439974 1236 dbSNP
rs576886306 1241 dbSNP
rs1161072503 1246 dbSNP
rs148803083 1257 dbSNP
rs1452906393 1272 dbSNP
rs1361077771 1276 dbSNP
rs1377281787 1282 dbSNP
rs1413027324 1284 dbSNP
rs961598597 1286 dbSNP
rs1312965641 1288 dbSNP
rs561154039 1289 dbSNP
rs1051541706 1290 dbSNP
rs1278548131 1296 dbSNP
rs1005831896 1297 dbSNP
rs1444944280 1304 dbSNP
rs1371252869 1307 dbSNP
rs780291063 1308 dbSNP
rs889443104 1315 dbSNP
rs933049664 1321 dbSNP
rs2422480 1326 dbSNP
rs564890037 1329 dbSNP
rs769340080 1330 dbSNP
rs963211677 1331 dbSNP
rs1387387632 1338 dbSNP
rs184768109 1346 dbSNP
rs772131816 1350 dbSNP
rs1480784525 1351 dbSNP
rs1178601033 1357 dbSNP
rs746015261 1358 dbSNP
rs1042172979 1360 dbSNP
rs531696276 1363 dbSNP
rs1396870480 1371 dbSNP
rs893662662 1376 dbSNP
rs1432937868 1389 dbSNP
rs1054099748 1401 dbSNP
rs1025590511 1405 dbSNP
rs1463687231 1406 dbSNP
rs1296674237 1408 dbSNP
rs1178908789 1411 dbSNP
rs1442174363 1415 dbSNP
rs937977138 1417 dbSNP
rs1369484628 1423 dbSNP
rs1472838763 1426 dbSNP
rs1003619769 1428 dbSNP
rs927247614 1433 dbSNP
rs1307600694 1439 dbSNP
rs866300845 1455 dbSNP
rs562505105 1457 dbSNP
rs1249271714 1467 dbSNP
rs745328360 1469 dbSNP
rs1202482707 1474 dbSNP
rs756079955 1477 dbSNP
rs111549843 1479 dbSNP
rs757185568 1483 dbSNP
rs950085758 1485 dbSNP
rs1023640938 1486 dbSNP
rs1012841546 1489 dbSNP
rs917357680 1490 dbSNP
rs1420235490 1491 dbSNP
rs1430396563 1494 dbSNP
rs893950746 1497 dbSNP
rs1054470041 1498 dbSNP
rs1462268745 1500 dbSNP
rs1328405873 1502 dbSNP
rs1392771173 1504 dbSNP
rs577464347 1509 dbSNP
rs1271288480 1516 dbSNP
rs1265699861 1521 dbSNP
rs1361966014 1527 dbSNP
rs961831942 1532 dbSNP
rs1220316716 1533 dbSNP
rs1321532735 1534 dbSNP
rs902215160 1543 dbSNP
rs1310947074 1553 dbSNP
rs539084170 1557 dbSNP
rs540425781 1565 dbSNP
rs1017138920 1567 dbSNP
rs1214068807 1572 dbSNP
rs540804358 1586 dbSNP
rs984778546 1593 dbSNP
rs139730569 1609 dbSNP
rs1028370124 1611 dbSNP
rs1288266565 1612 dbSNP
rs192569638 1613 dbSNP
rs537892127 1614 dbSNP
rs568983396 1616 dbSNP
rs997818513 1619 dbSNP
rs900906199 1620 dbSNP
rs1405151346 1626 dbSNP
rs900263713 1631 dbSNP
rs1020641685 1635 dbSNP
rs1286660824 1641 dbSNP
rs754870126 1643 dbSNP
rs941877752 1645 dbSNP
rs145967192 1647 dbSNP
rs1053664316 1657 dbSNP
rs1332397947 1658 dbSNP
rs187611537 1663 dbSNP
rs983806216 1676 dbSNP
rs1284832057 1678 dbSNP
rs1318715164 1679 dbSNP
rs937892478 1685 dbSNP
rs929219891 1686 dbSNP
rs1262519786 1688 dbSNP
rs566735984 1691 dbSNP
rs1486043962 1698 dbSNP
rs1411232897 1706 dbSNP
rs1179881985 1718 dbSNP
rs546544700 1732 dbSNP
rs530025561 1733 dbSNP
rs905122290 1734 dbSNP
rs1044396128 1737 dbSNP
rs1159545147 1739 dbSNP
rs950014827 1742 dbSNP
rs1242051064 1748 dbSNP
rs15443 1754 dbSNP
rs970673340 1754 dbSNP
rs1023693039 1755 dbSNP
rs567076013 1765 dbSNP
rs1338377789 1770 dbSNP
rs958477976 1775 dbSNP
rs547275057 1776 dbSNP
rs1307230209 1783 dbSNP
rs1000225583 1791 dbSNP
rs1285234311 1792 dbSNP
rs940162094 1794 dbSNP
rs1211045867 1795 dbSNP
rs1330206869 1812 dbSNP
rs550370714 1813 dbSNP
rs766203107 1821 dbSNP
rs984310634 1828 dbSNP
rs531686567 1831 dbSNP
rs1301986478 1832 dbSNP
rs1178557271 1836 dbSNP
rs1386436202 1852 dbSNP
rs1365823982 1853 dbSNP
rs1434767274 1859 dbSNP
rs1175028932 1862 dbSNP
rs900147559 1869 dbSNP
rs954410766 1889 dbSNP
rs1322796770 1890 dbSNP
rs1337252817 1890 dbSNP
rs921535888 1890 dbSNP
rs1457606216 1893 dbSNP
rs1387603945 1897 dbSNP
rs1156899079 1898 dbSNP
rs1467462844 1899 dbSNP
rs976995378 1902 dbSNP
rs12796203 1906 dbSNP
rs184676248 1912 dbSNP
rs12797909 1913 dbSNP
rs1196531995 1916 dbSNP
rs12796386 1919 dbSNP
rs12797906 1920 dbSNP
rs941780058 1924 dbSNP
rs1188781377 1926 dbSNP
rs1465650188 1927 dbSNP
rs77063826 1931 dbSNP
rs1375365233 1932 dbSNP
rs572729913 1932 dbSNP
rs1477418501 1934 dbSNP
rs1168119861 1937 dbSNP
rs1207392673 1937 dbSNP
rs1463834437 1938 dbSNP
rs199952011 1943 dbSNP
rs11039254 1944 dbSNP
rs1330534182 1944 dbSNP
rs1394969790 1944 dbSNP
rs199602931 1944 dbSNP
rs397774759 1944 dbSNP
rs5791762 1944 dbSNP
rs79826098 1944 dbSNP
rs201259828 1945 dbSNP
rs1228333527 1946 dbSNP
rs1272115880 1948 dbSNP
rs1347684064 1950 dbSNP
rs749966472 1962 dbSNP
rs1020611992 1964 dbSNP
rs1009728222 1969 dbSNP
rs1257082729 1970 dbSNP
rs1274159558 1972 dbSNP
rs1470113679 1975 dbSNP
rs887645244 1987 dbSNP
rs957820121 1988 dbSNP
rs1450531014 1992 dbSNP
rs1193327684 1996 dbSNP
rs1374410272 1998 dbSNP
rs1476606578 2003 dbSNP
rs77419618 2004 dbSNP
rs80211172 2006 dbSNP
rs1462829102 2007 dbSNP
rs765599285 2024 dbSNP
rs777591448 2030 dbSNP
rs1300154948 2033 dbSNP
rs1382826101 2039 dbSNP
rs762417673 2040 dbSNP
rs905049920 2041 dbSNP
rs1399566312 2050 dbSNP
rs1294153043 2061 dbSNP
rs916573450 2069 dbSNP
rs1046335360 2083 dbSNP
rs1397552544 2089 dbSNP
rs1265337151 2090 dbSNP
rs532437123 2113 dbSNP
rs1207429920 2114 dbSNP
rs958146256 2118 dbSNP
rs895820013 2120 dbSNP
rs1192405490 2121 dbSNP
rs1302162889 2124 dbSNP
rs1464150485 2129 dbSNP
rs1162492165 2133 dbSNP
rs1391429585 2137 dbSNP
rs1168869603 2150 dbSNP
rs1367702690 2153 dbSNP
rs1037038861 2158 dbSNP
rs1454213634 2158 dbSNP
rs1358644205 2160 dbSNP
rs1389961220 2166 dbSNP
rs1032801936 2167 dbSNP
rs1187130437 2170 dbSNP
rs1444481425 2200 dbSNP
rs978265834 2212 dbSNP
rs966841701 2215 dbSNP
rs1200360027 2216 dbSNP
rs1030607856 2224 dbSNP
rs1482328805 2225 dbSNP
rs1350842376 2230 dbSNP
rs1215342644 2236 dbSNP
rs1276784194 2237 dbSNP
rs560548607 2239 dbSNP
rs540541264 2252 dbSNP
rs1341797604 2253 dbSNP
rs1295677955 2254 dbSNP
rs909978841 2256 dbSNP
rs1049015419 2265 dbSNP
rs1378480093 2271 dbSNP
rs1419135615 2284 dbSNP
rs1174389841 2289 dbSNP
rs1377373375 2289 dbSNP
rs997752075 2294 dbSNP
rs900201634 2297 dbSNP
rs758168220 2302 dbSNP
rs1307701041 2303 dbSNP
rs1394178438 2304 dbSNP
rs1376877330 2305 dbSNP
rs921460446 2306 dbSNP
rs887540061 2309 dbSNP
rs575078194 2310 dbSNP
rs1308052477 2315 dbSNP
rs776816543 2316 dbSNP
rs1428522665 2322 dbSNP
rs1255115178 2324 dbSNP
rs34290720 2325 dbSNP
rs993308662 2332 dbSNP
rs907026128 2333 dbSNP
rs764407002 2335 dbSNP
rs987838497 2341 dbSNP
rs1438950248 2343 dbSNP
rs761091099 2346 dbSNP
rs775673854 2350 dbSNP
rs1194217119 2352 dbSNP
rs1427273820 2354 dbSNP
rs958004649 2355 dbSNP
rs1431523599 2368 dbSNP
rs1175608872 2372 dbSNP
rs561425255 2374 dbSNP
rs544860635 2376 dbSNP
rs1373921460 2377 dbSNP
rs1254580569 2380 dbSNP
rs1206047387 2389 dbSNP
rs1032074408 2394 dbSNP
rs1400066830 2399 dbSNP
rs1002392300 2400 dbSNP
rs35408275 2403 dbSNP
rs1442197918 2406 dbSNP
rs948632574 2409 dbSNP
rs142467461 2414 dbSNP
rs1217040839 2415 dbSNP
rs558712185 2421 dbSNP
rs1211812038 2433 dbSNP
rs1024854727 2442 dbSNP
rs187305704 2449 dbSNP
rs112953599 2451 dbSNP
rs936634970 2455 dbSNP
rs1248441930 2462 dbSNP
rs1356825539 2466 dbSNP
rs925405645 2472 dbSNP
rs745867708 2480 dbSNP
rs978149545 2488 dbSNP
rs1478902726 2491 dbSNP
rs966894035 2491 dbSNP
rs112220075 2507 dbSNP
rs1242530713 2508 dbSNP
rs1037409230 2510 dbSNP
rs1004234397 2527 dbSNP
rs964989890 2529 dbSNP
rs1433651852 2543 dbSNP
rs888466713 2546 dbSNP
rs1292383933 2564 dbSNP
rs1401387343 2566 dbSNP
rs1005896023 2576 dbSNP
rs75682801 2577 dbSNP
rs1026042447 2579 dbSNP
rs907080175 2580 dbSNP
rs1045539672 2581 dbSNP
rs1242709113 2581 dbSNP
rs1191766608 2586 dbSNP
rs932762392 2589 dbSNP
rs769569414 2611 dbSNP
rs1184015713 2614 dbSNP
rs1405547684 2615 dbSNP
rs1405243287 2617 dbSNP
rs894400958 2618 dbSNP
rs921430654 2619 dbSNP
rs1421050860 2634 dbSNP
rs1054753099 2636 dbSNP
rs1041198346 2640 dbSNP
rs1414893163 2666 dbSNP
rs1415145592 2667 dbSNP
rs936705106 2671 dbSNP
rs1376706518 2672 dbSNP
rs925259602 2673 dbSNP
rs1042527140 2675 dbSNP
rs567265377 2677 dbSNP
rs748095945 2681 dbSNP
rs1201288913 2682 dbSNP
rs1452342174 2690 dbSNP
rs923309243 2693 dbSNP
rs550362038 2713 dbSNP
rs1472680858 2714 dbSNP
rs936338761 2722 dbSNP
rs1382771215 2728 dbSNP
rs781319608 2735 dbSNP
rs924976754 2742 dbSNP
rs1211658366 2745 dbSNP
rs1359372243 2749 dbSNP
rs1414617868 2763 dbSNP
rs1330910462 2765 dbSNP
rs980546260 2766 dbSNP
rs969131311 2767 dbSNP
rs1024781151 2769 dbSNP
rs951774537 2773 dbSNP
rs1379093286 2774 dbSNP
rs536875140 2777 dbSNP
rs1276038286 2779 dbSNP
rs1436559171 2786 dbSNP
rs1330224528 2791 dbSNP
rs1202332842 2794 dbSNP
rs993247781 2802 dbSNP
rs961930086 2805 dbSNP
rs1321147111 2813 dbSNP
rs1014823265 2820 dbSNP
rs1023976004 2830 dbSNP
rs568996386 2831 dbSNP
rs1465354477 2834 dbSNP
rs137858363 2838 dbSNP
rs1178575512 2839 dbSNP
rs1379092846 2842 dbSNP
rs779798076 2844 dbSNP
rs758078034 2848 dbSNP
rs1173967149 2850 dbSNP
rs749863564 2856 dbSNP
rs1032955619 2858 dbSNP
rs996847295 2864 dbSNP
rs899934764 2867 dbSNP
rs1402235986 2868 dbSNP
rs1000510521 2870 dbSNP
rs1330603565 2874 dbSNP
rs1041173651 2884 dbSNP
rs944192389 2885 dbSNP
rs903889012 2892 dbSNP
rs750524281 2893 dbSNP
rs1042413136 2913 dbSNP
rs548088351 2915 dbSNP
rs945323224 2917 dbSNP
rs892665786 2924 dbSNP
rs532658738 2928 dbSNP
rs1316462354 2938 dbSNP
rs1198557247 2948 dbSNP
rs1254254131 2959 dbSNP
rs901940249 2963 dbSNP
rs1040456092 2970 dbSNP
rs1244502925 2972 dbSNP
rs35726813 2972 dbSNP
rs74571537 2973 dbSNP
rs924935395 2978 dbSNP
rs1425425196 2979 dbSNP
rs1463919224 2982 dbSNP
rs985094255 2991 dbSNP
rs980856149 2992 dbSNP
rs767744332 2996 dbSNP
rs1321617515 3008 dbSNP
rs947754207 3010 dbSNP
rs917688228 3012 dbSNP
rs1246385221 3015 dbSNP
rs971008781 3017 dbSNP
rs991930510 3019 dbSNP
rs1400778245 3021 dbSNP
rs1280399649 3022 dbSNP
rs1191956645 3023 dbSNP
rs1466101845 3026 dbSNP
rs1248365843 3036 dbSNP
rs1208032289 3041 dbSNP
rs182959427 3051 dbSNP
rs1208616867 3053 dbSNP
rs1024028481 3059 dbSNP
rs1450548870 3059 dbSNP
rs1193910753 3064 dbSNP
rs1015204721 3073 dbSNP
rs1219350686 3078 dbSNP
rs984721567 3096 dbSNP
rs1033253248 3097 dbSNP
rs1368854389 3106 dbSNP
rs952058343 3116 dbSNP
rs1161395050 3127 dbSNP
rs1026952873 3143 dbSNP
rs1272740538 3161 dbSNP
rs996822077 3161 dbSNP
rs1420457492 3162 dbSNP
rs530408082 3173 dbSNP
rs999991162 3187 dbSNP
rs1399655292 3188 dbSNP
rs1230109135 3194 dbSNP
rs1019645524 3202 dbSNP
rs1313836759 3205 dbSNP
rs1342646153 3209 dbSNP
rs561614150 3216 dbSNP
rs1284183714 3217 dbSNP
rs892633751 3218 dbSNP
rs1009587894 3221 dbSNP
rs901825761 3253 dbSNP
rs1336684980 3254 dbSNP
rs1040490578 3272 dbSNP
rs1185326340 3272 dbSNP
rs141316553 3272 dbSNP
rs943440340 3272 dbSNP
rs1367861852 3273 dbSNP
rs1415160562 3274 dbSNP
rs889329461 3274 dbSNP
rs1424482901 3281 dbSNP
rs1049698804 3282 dbSNP
rs1303663296 3291 dbSNP
rs936905937 3292 dbSNP
rs1161524434 3298 dbSNP
rs148269523 3306 dbSNP
rs1390571647 3308 dbSNP
rs1312592023 3312 dbSNP
rs919523798 3323 dbSNP
rs1187773923 3325 dbSNP
rs1484754859 3334 dbSNP
rs146701169 3335 dbSNP
rs747293921 3335 dbSNP
rs1350867792 3342 dbSNP
rs972266899 3342 dbSNP
rs146213933 3347 dbSNP
rs1044726759 3348 dbSNP
rs754335211 3350 dbSNP
rs947680971 3352 dbSNP
rs1239192228 3356 dbSNP
rs949747762 3356 dbSNP
rs190722264 3359 dbSNP
rs1242328233 3373 dbSNP
rs1458129992 3377 dbSNP
rs917616175 3378 dbSNP
rs1056217112 3386 dbSNP
rs1378498625 3387 dbSNP
rs1439221132 3391 dbSNP
rs572904928 3395 dbSNP
rs958700120 3398 dbSNP
rs907659945 3432 dbSNP
rs1230180788 3436 dbSNP
rs552684504 3451 dbSNP
rs951968315 3455 dbSNP
rs1296410707 3466 dbSNP
rs921825942 3467 dbSNP
rs974660885 3469 dbSNP
rs1449565276 3490 dbSNP
rs964006575 3496 dbSNP
rs1329925607 3498 dbSNP
rs764640041 3498 dbSNP
rs1360286788 3502 dbSNP
rs563650592 3506 dbSNP
rs1230645175 3513 dbSNP
rs3087947 3516 dbSNP
rs35996141 3516 dbSNP
rs752058606 3516 dbSNP
rs967178497 3516 dbSNP
rs1480333807 3518 dbSNP
rs1191898277 3520 dbSNP
rs1269590102 3524 dbSNP
rs1431616825 3524 dbSNP
rs957016174 3536 dbSNP
rs775835336 3537 dbSNP
rs187754172 3538 dbSNP
rs1293559516 3539 dbSNP
rs1369104294 3539 dbSNP
rs966067234 3539 dbSNP
rs767684730 3544 dbSNP
rs1256022671 3545 dbSNP
rs1371449171 3545 dbSNP
rs1340887535 3547 dbSNP
rs1220286426 3554 dbSNP
rs1168178588 3558 dbSNP
rs1306802497 3559 dbSNP
rs1426547172 3571 dbSNP
rs1415644524 3572 dbSNP
rs543768595 3579 dbSNP
rs1267230487 3581 dbSNP
rs1487555025 3586 dbSNP
rs1198951480 3587 dbSNP
rs536966048 3589 dbSNP
rs1264220824 3597 dbSNP
rs1478994123 3598 dbSNP
rs1191892526 3601 dbSNP
rs1419287015 3601 dbSNP
rs571078440 3606 dbSNP
rs551554566 3612 dbSNP
rs1255304798 3620 dbSNP
rs1351099716 3620 dbSNP
rs774484632 3621 dbSNP
rs1302116400 3641 dbSNP
rs994985161 3643 dbSNP
rs1401490614 3646 dbSNP
rs1045327061 3648 dbSNP
rs1361019112 3656 dbSNP
rs1228758589 3667 dbSNP
rs578053892 3669 dbSNP
rs896150167 3672 dbSNP
rs1221906563 3680 dbSNP
rs897982287 3681 dbSNP
rs1036603418 3684 dbSNP
rs1241830849 3689 dbSNP
rs1473362057 3696 dbSNP
rs950297284 3698 dbSNP
rs1412311100 3701 dbSNP
rs1056144610 3706 dbSNP
rs1442222431 3708 dbSNP
rs1162327816 3711 dbSNP
rs940418502 3712 dbSNP
rs1306153770 3713 dbSNP
rs1315804062 3714 dbSNP
rs1344373857 3715 dbSNP
rs1292380515 3737 dbSNP
rs1304490331 3740 dbSNP
rs1055873653 3747 dbSNP
rs749396265 3748 dbSNP
rs538714231 3749 dbSNP
rs113708740 3750 dbSNP
rs967232283 3775 dbSNP
rs770272288 3790 dbSNP
rs1443319470 3794 dbSNP
rs1351131816 3796 dbSNP
rs1212747384 3798 dbSNP
rs763312224 3807 dbSNP
rs1461231712 3811 dbSNP
rs1460598466 3816 dbSNP
rs566992839 3832 dbSNP
rs1179821654 3835 dbSNP
rs142163892 3838 dbSNP
rs115779652 3851 dbSNP
rs965938985 3853 dbSNP
rs1406845354 3860 dbSNP
rs1404544235 3863 dbSNP
rs1415631277 3864 dbSNP
rs1184228158 3874 dbSNP
rs912531669 3875 dbSNP
rs1156659866 3876 dbSNP
rs1177917151 3877 dbSNP
rs1403639195 3879 dbSNP
rs1472645699 3886 dbSNP
rs746736658 3887 dbSNP
rs1332022508 3889 dbSNP
rs1250367040 3903 dbSNP
rs1175119554 3907 dbSNP
rs953383058 3908 dbSNP
rs986778487 3914 dbSNP
rs1222827618 3921 dbSNP
rs1028178766 3926 dbSNP
rs1271855547 3927 dbSNP
rs1279160609 3928 dbSNP
rs561549938 3930 dbSNP
rs377227389 3932 dbSNP
rs370403413 3933 dbSNP
rs1199808646 3947 dbSNP
rs1323293230 3947 dbSNP
rs1306311860 3951 dbSNP
rs1178984978 3952 dbSNP
rs1458692524 3952 dbSNP
rs528422329 3952 dbSNP
rs1478112175 3960 dbSNP
rs1031482685 3965 dbSNP
rs1000984552 3966 dbSNP
rs1036488890 3969 dbSNP
rs968612373 3979 dbSNP
rs1402430444 3981 dbSNP
rs1389732469 3991 dbSNP
rs531234987 3997 dbSNP
rs1023846662 4001 dbSNP
rs199995378 4003 dbSNP
rs369566397 4003 dbSNP
rs1331763086 4009 dbSNP
rs1438809034 4014 dbSNP
rs1345271350 4018 dbSNP
rs879679788 4018 dbSNP
rs896067101 4025 dbSNP
rs1260528877 4027 dbSNP
rs1316550689 4035 dbSNP
rs565298127 4036 dbSNP
rs1271606609 4040 dbSNP
rs1451733257 4053 dbSNP
rs545624506 4060 dbSNP
rs1266377846 4061 dbSNP
rs896748308 4062 dbSNP
rs111593711 4065 dbSNP
rs1004974070 4069 dbSNP
rs559428581 4072 dbSNP
rs886134989 4080 dbSNP
rs1167278842 4081 dbSNP
rs1052657 4082 dbSNP
rs1407220413 4085 dbSNP
rs1301491686 4093 dbSNP
rs912946090 4096 dbSNP
rs1400873747 4097 dbSNP
rs1280416566 4101 dbSNP
rs976589433 4105 dbSNP
rs1227324448 4107 dbSNP
rs1285369163 4119 dbSNP
rs1161318356 4127 dbSNP
rs1457640959 4129 dbSNP
rs930449478 4131 dbSNP
rs1224130478 4134 dbSNP
rs1410598934 4134 dbSNP
rs573270337 4137 dbSNP
rs1038852951 4138 dbSNP
rs944598788 4140 dbSNP
rs911830301 4143 dbSNP
rs985377706 4143 dbSNP
rs1445128286 4146 dbSNP
rs745516706 4146 dbSNP
rs1369029658 4150 dbSNP
rs988770978 4153 dbSNP
rs1161698975 4154 dbSNP
rs1384691374 4161 dbSNP
rs1190223596 4167 dbSNP
rs1300343582 4171 dbSNP
rs935313545 4171 dbSNP
rs1382048539 4173 dbSNP
rs923997009 4179 dbSNP
rs1251452321 4185 dbSNP
rs1244457600 4193 dbSNP
rs979920763 4195 dbSNP
rs1211144812 4197 dbSNP
rs953533779 4201 dbSNP
rs1262196562 4202 dbSNP
rs968160918 4212 dbSNP
rs190844690 4217 dbSNP
rs1484754139 4219 dbSNP
rs1204385261 4224 dbSNP
rs1256622639 4228 dbSNP
rs1444000844 4232 dbSNP
rs1023774428 4234 dbSNP
rs1260650264 4235 dbSNP
rs1440468261 4238 dbSNP
rs1237021348 4245 dbSNP
rs1160645239 4250 dbSNP
rs185936690 4251 dbSNP
rs1173479717 4253 dbSNP
rs1314001055 4255 dbSNP
rs1451028100 4258 dbSNP
rs1336721595 4263 dbSNP
rs973500231 4268 dbSNP
rs1446937671 4272 dbSNP
rs1491302078 4273 dbSNP
rs1314714050 4274 dbSNP
rs1491207144 4274 dbSNP
rs1233787852 4278 dbSNP
rs1256311097 4281 dbSNP
rs763614856 4288 dbSNP
rs577523524 4292 dbSNP
rs1435526116 4300 dbSNP
rs1014930787 4302 dbSNP
rs372536437 4303 dbSNP
rs1248544649 4313 dbSNP
rs960924584 4322 dbSNP
rs1014392035 4325 dbSNP
rs1287026527 4327 dbSNP
rs1035257311 4328 dbSNP
rs1199873242 4332 dbSNP
rs895964594 4337 dbSNP
rs1468633622 4338 dbSNP
rs1287099156 4341 dbSNP
rs557145148 4353 dbSNP
rs1401724138 4361 dbSNP
rs1467667041 4362 dbSNP
rs1005168995 4366 dbSNP
rs1377659933 4383 dbSNP
rs1001784764 4399 dbSNP
rs1370556756 4403 dbSNP
rs886103000 4404 dbSNP
rs1301625184 4415 dbSNP
rs1452126911 4417 dbSNP
rs557655989 4418 dbSNP
rs778493500 4424 dbSNP
rs900276342 4425 dbSNP
rs1465607346 4430 dbSNP
rs1206538209 4435 dbSNP
rs891564551 4437 dbSNP
rs1203850346 4439 dbSNP
rs1484293319 4446 dbSNP
rs1040792997 4447 dbSNP
rs943894166 4456 dbSNP
rs1479649308 4467 dbSNP
rs1199089660 4468 dbSNP
rs911045574 4476 dbSNP
rs985816454 4477 dbSNP
rs1169024737 4484 dbSNP
rs756775198 4487 dbSNP
rs147051157 4488 dbSNP
rs944526722 4492 dbSNP
rs1300088356 4497 dbSNP
rs566829188 4498 dbSNP
rs1228917170 4507 dbSNP
rs1402747520 4514 dbSNP
rs1325590394 4519 dbSNP
rs890313797 4527 dbSNP
rs1053434545 4529 dbSNP
rs1293433345 4530 dbSNP
rs148955629 4530 dbSNP
rs1245681987 4541 dbSNP
rs1402313897 4556 dbSNP
rs1489909566 4558 dbSNP
rs536758852 4559 dbSNP
rs1264330772 4563 dbSNP
rs567618681 4568 dbSNP
rs1311814018 4574 dbSNP
rs1487092110 4577 dbSNP
rs1185257349 4584 dbSNP
rs973385772 4591 dbSNP
rs1372069954 4596 dbSNP
rs1424921916 4608 dbSNP
rs1163620496 4619 dbSNP
rs1168813726 4622 dbSNP
rs979464119 4623 dbSNP
rs1475956918 4627 dbSNP
rs946754305 4630 dbSNP
rs1432688951 4632 dbSNP
rs1191665083 4636 dbSNP
rs181043887 4637 dbSNP
rs1317169534 4642 dbSNP
rs990927190 4653 dbSNP
rs960857959 4656 dbSNP
rs1035235332 4657 dbSNP
rs1034519835 4662 dbSNP
rs1187393893 4662 dbSNP
rs759253752 4666 dbSNP
rs1483824413 4669 dbSNP
rs1185975692 4672 dbSNP
rs1244428344 4678 dbSNP
rs904780506 4679 dbSNP
rs1162503400 4680 dbSNP
rs1408332879 4700 dbSNP
rs1484713269 4701 dbSNP
rs1402111603 4704 dbSNP
rs531222846 4708 dbSNP
rs1009924704 4716 dbSNP
rs1338693196 4720 dbSNP
rs1380633662 4722 dbSNP
rs891450287 4725 dbSNP
rs1206090886 4727 dbSNP
rs1338511577 4739 dbSNP
rs1249345017 4745 dbSNP
rs1375745316 4746 dbSNP
rs951005679 4748 dbSNP
rs756638228 4749 dbSNP
rs1206120610 4757 dbSNP
rs943796874 4763 dbSNP
rs1459578018 4767 dbSNP
rs571955987 4770 dbSNP
rs889658873 4776 dbSNP
rs1470921836 4778 dbSNP
rs1246707772 4790 dbSNP
rs994533313 4794 dbSNP
rs1406963736 4800 dbSNP
rs1470159714 4801 dbSNP
rs1341066138 4805 dbSNP
rs964372172 4807 dbSNP
rs1017292389 4816 dbSNP
rs551662517 4822 dbSNP
rs890287376 4823 dbSNP
rs1052962309 4825 dbSNP
rs1440270995 4841 dbSNP
rs1279257619 4849 dbSNP
rs919860064 4853 dbSNP
rs972604729 4854 dbSNP
rs999145765 4861 dbSNP
rs904453584 4879 dbSNP
rs1199828184 4882 dbSNP
rs1273026895 4892 dbSNP
rs866089286 4895 dbSNP
rs1044095530 4900 dbSNP
rs907872281 4902 dbSNP
rs1202001367 4903 dbSNP
rs1232001466 4904 dbSNP
rs993359986 4905 dbSNP
rs73461720 4911 dbSNP
rs559715604 4919 dbSNP
rs191108105 4920 dbSNP
rs1168479266 4921 dbSNP
rs1459764423 4928 dbSNP
rs1398718912 4933 dbSNP
rs980308338 4939 dbSNP
rs969267992 4944 dbSNP
rs1366378652 4948 dbSNP
rs1055212298 4949 dbSNP
rs939418407 4960 dbSNP
rs1010480674 4964 dbSNP
rs1345289717 4966 dbSNP
rs866040297 4967 dbSNP
rs188179088 4971 dbSNP
rs1340831143 4975 dbSNP
rs71475917 4982 dbSNP
rs1212245937 4983 dbSNP
rs1019289490 4984 dbSNP
rs1490392207 4988 dbSNP
rs983649567 5000 dbSNP
rs376211958 5003 dbSNP
rs951008355 5009 dbSNP
rs1490143296 5013 dbSNP
rs1193768459 5015 dbSNP
rs1374774041 5016 dbSNP
rs181432501 5018 dbSNP
rs1167369868 5019 dbSNP
rs920836006 5020 dbSNP
rs1049918029 5022 dbSNP
rs973652336 5026 dbSNP
rs762404265 5027 dbSNP
rs188986138 5028 dbSNP
rs1248686449 5035 dbSNP
rs577854246 5046 dbSNP
rs898319327 5047 dbSNP
rs1036941555 5048 dbSNP
rs753021761 5061 dbSNP
rs939936802 5062 dbSNP
rs1356763734 5064 dbSNP
rs1296148702 5065 dbSNP
rs1272492949 5085 dbSNP
rs1231335017 5088 dbSNP
rs767892637 5096 dbSNP
rs1288360884 5107 dbSNP
rs1289192995 5107 dbSNP
rs1440819288 5108 dbSNP
rs1355352702 5121 dbSNP
rs1205456977 5125 dbSNP
rs1008564511 5134 dbSNP
rs1263627780 5138 dbSNP
rs1445147851 5147 dbSNP
rs1192399897 5148 dbSNP
rs917793388 5151 dbSNP
rs1446593424 5163 dbSNP
rs1161871266 5171 dbSNP
rs954470729 5172 dbSNP
rs1384788051 5179 dbSNP
rs1388935263 5185 dbSNP
rs145694200 5192 dbSNP
rs1160589907 5202 dbSNP
rs1383277952 5206 dbSNP
rs998718027 5213 dbSNP
rs1460285182 5216 dbSNP
rs1338033703 5220 dbSNP
rs1414820276 5229 dbSNP
rs1159293417 5236 dbSNP
rs1454161603 5237 dbSNP
rs1469667884 5237 dbSNP
rs1312309653 5244 dbSNP
rs540851882 5246 dbSNP
rs572821940 5247 dbSNP
rs1239328167 5248 dbSNP
rs927419627 5251 dbSNP
rs1201217615 5254 dbSNP
rs759866488 5260 dbSNP
rs1252070401 5261 dbSNP
rs1462695083 5267 dbSNP
rs1181785531 5276 dbSNP
rs1242613101 5278 dbSNP
rs1419833296 5284 dbSNP
rs36060230 5289 dbSNP
rs980576236 5289 dbSNP
rs1362414160 5292 dbSNP
rs537465879 5292 dbSNP
rs895107920 5298 dbSNP
rs1408879037 5305 dbSNP
rs1468733844 5319 dbSNP
rs572172045 5330 dbSNP
rs555622363 5335 dbSNP
rs939387144 5338 dbSNP
rs1466242387 5345 dbSNP
rs914737414 5362 dbSNP
rs1400893754 5363 dbSNP
rs1222747882 5364 dbSNP
rs776093235 5367 dbSNP
rs1308782658 5371 dbSNP
rs928087055 5383 dbSNP
rs1048299295 5393 dbSNP
rs1227613017 5394 dbSNP
rs11546837 5396 dbSNP
rs956280113 5397 dbSNP
rs929475514 5398 dbSNP
rs1020254474 5399 dbSNP
rs1276269878 5400 dbSNP
rs1201703355 5408 dbSNP
rs920792635 5419 dbSNP
rs536704719 5420 dbSNP
rs1007909730 5422 dbSNP
rs1248741699 5424 dbSNP
rs1233439422 5428 dbSNP
rs973625988 5428 dbSNP
rs964936408 5435 dbSNP
rs1028099748 5437 dbSNP
rs75336726 5447 dbSNP
rs1325721383 5453 dbSNP
rs751793248 5456 dbSNP
rs954589992 5457 dbSNP
rs1319534958 5472 dbSNP
rs1400217982 5477 dbSNP
rs557390114 5481 dbSNP
rs977603371 5484 dbSNP
rs1300554589 5485 dbSNP
rs1802814 5490 dbSNP
rs1003968073 5496 dbSNP
rs1229639836 5497 dbSNP
rs766575306 5502 dbSNP
rs1021470255 5504 dbSNP
rs1482814698 5509 dbSNP
rs1382827060 5511 dbSNP
rs1174539036 5518 dbSNP
rs1012804834 5523 dbSNP
rs537472388 5528 dbSNP
rs763058410 5529 dbSNP
rs12054 5533 dbSNP
rs1263112546 5535 dbSNP
rs1003525625 5543 dbSNP
rs1171821287 5549 dbSNP
rs1191586263 5550 dbSNP
rs1163897520 5556 dbSNP
rs568447899 5556 dbSNP
rs571834471 5556 dbSNP
rs1451064079 5558 dbSNP
rs1292749687 5573 dbSNP
rs1362521177 5574 dbSNP
rs1242681142 5589 dbSNP
rs938719415 5604 dbSNP
rs1047797397 5606 dbSNP
rs929422025 5607 dbSNP
rs927273767 5610 dbSNP
rs899294276 5611 dbSNP
rs1213795291 5612 dbSNP
rs184537598 5622 dbSNP
rs1346786710 5627 dbSNP
rs1300771481 5629 dbSNP
rs1294278638 5642 dbSNP
rs1232626398 5645 dbSNP
rs1367735697 5649 dbSNP
rs1271320288 5650 dbSNP
rs1430556783 5651 dbSNP
rs947371267 5654 dbSNP
rs376848481 5655 dbSNP
rs1062801 5656 dbSNP
rs397790422 5657 dbSNP
rs1435409345 5659 dbSNP
rs1062802 5668 dbSNP
rs1414853167 5668 dbSNP
rs555328608 5668 dbSNP
rs55702363 5668 dbSNP
rs1183798277 5669 dbSNP
rs1386653855 5670 dbSNP
rs1403275519 5672 dbSNP
rs1345581516 5697 dbSNP
rs1037843737 5700 dbSNP
rs914614689 5702 dbSNP
rs943596618 5719 dbSNP
rs910823538 5720 dbSNP
rs987707028 5723 dbSNP
rs932989816 5725 dbSNP
rs924306505 5740 dbSNP
rs1380807797 5766 dbSNP
rs1171984758 5774 dbSNP
rs1431420667 5781 dbSNP
rs977158845 5795 dbSNP
rs1214228969 5804 dbSNP
rs1203702692 5813 dbSNP
rs1268105430 5813 dbSNP
rs989052209 5813 dbSNP
rs934927639 5819 dbSNP
rs968880080 5821 dbSNP
rs1180985571 5822 dbSNP
rs555880730 5830 dbSNP
rs1420697582 5837 dbSNP
rs1156835900 5838 dbSNP
rs1387758957 5843 dbSNP
rs1332074210 5844 dbSNP
rs991337982 5851 dbSNP
rs953789312 5853 dbSNP
rs528806821 5855 dbSNP
rs566215535 5856 dbSNP
rs1035590662 5864 dbSNP
rs1222376337 5868 dbSNP
rs773436905 5872 dbSNP
rs1324811010 5874 dbSNP
rs1485048137 5875 dbSNP
rs906529000 5876 dbSNP
rs182103465 5886 dbSNP
rs528944422 5887 dbSNP
rs1233153405 5889 dbSNP
rs1481425634 5896 dbSNP
rs576060036 5901 dbSNP
rs1410963122 5902 dbSNP
rs1037812639 5905 dbSNP
rs1178578786 5906 dbSNP
rs1480713548 5906 dbSNP
rs1423109523 5911 dbSNP
rs1414023208 5933 dbSNP
rs1329648513 5934 dbSNP
rs1356455637 5936 dbSNP
rs1408235310 5942 dbSNP
rs1004068008 5954 dbSNP
rs1225884584 5956 dbSNP
rs896411962 5956 dbSNP
rs796168333 5964 dbSNP
rs776405939 5966 dbSNP
rs775604224 5972 dbSNP
rs889312043 5976 dbSNP
rs1273140973 5977 dbSNP
rs1002454451 5985 dbSNP
rs1202609404 5988 dbSNP
rs1360566731 5990 dbSNP
rs374301147 5999 dbSNP
rs933570447 6001 dbSNP
rs1244856465 6002 dbSNP
rs1044870380 6008 dbSNP
rs947484726 6011 dbSNP
rs1421756636 6016 dbSNP
rs1428053860 6027 dbSNP
rs35975573 6027 dbSNP
rs112866503 6029 dbSNP
rs977503565 6032 dbSNP
rs1044269 6042 dbSNP
rs771915678 6045 dbSNP
rs1322016440 6052 dbSNP
rs991264219 6059 dbSNP
rs1053131180 6074 dbSNP
rs1270216760 6085 dbSNP
rs1366818008 6090 dbSNP
rs934873660 6099 dbSNP
rs1273526842 6100 dbSNP
rs201455895 6100 dbSNP
rs549342993 6105 dbSNP
rs539183522 6106 dbSNP
rs986949781 6122 dbSNP
rs563940296 6124 dbSNP
rs928489367 6126 dbSNP
rs1193882344 6135 dbSNP
rs1243916310 6136 dbSNP
rs1447778881 6138 dbSNP
rs1188143066 6141 dbSNP
rs932811656 6156 dbSNP
rs1390486105 6158 dbSNP
rs746899080 6158 dbSNP
rs921477529 6158 dbSNP
rs1411839224 6160 dbSNP
rs1355324134 6162 dbSNP
rs1401784984 6169 dbSNP
rs778563891 6176 dbSNP
rs1407972917 6180 dbSNP
rs190805366 6184 dbSNP
rs74768328 6188 dbSNP
rs1165504869 6189 dbSNP
rs1015190774 6195 dbSNP
rs1246551722 6205 dbSNP
rs149776003 6213 dbSNP
rs1355463819 6215 dbSNP
rs1254691838 6220 dbSNP
rs770505350 6223 dbSNP
rs112046730 6235 dbSNP
rs1208147684 6237 dbSNP
rs963372122 6243 dbSNP
rs1480786443 6248 dbSNP
rs1243832851 6253 dbSNP
rs1231947082 6254 dbSNP
rs1204312512 6259 dbSNP
rs1368221603 6273 dbSNP
rs1035350520 6274 dbSNP
rs1160672123 6282 dbSNP
rs777601481 6287 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions TZM-bl
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM1462574. RNA binding protein: AGO2. Condition:TZM-bl ami BaL ...

- Whisnant AW; Bogerd HP; Flores O; Ho P; et al., 2013, mBio.

Article - Whisnant AW; Bogerd HP; Flores O; Ho P; et al.
- mBio, 2013
UNLABELLED: The question of how HIV-1 interfaces with cellular microRNA (miRNA) biogenesis and effector mechanisms has been highly controversial. Here, we first used deep sequencing of small RNAs present in two different infected cell lines (TZM-bl and C8166) and two types of primary human cells (CD4(+) peripheral blood mononuclear cells [PBMCs] and macrophages) to unequivocally demonstrate that HIV-1 does not encode any viral miRNAs. Perhaps surprisingly, we also observed that infection of T cells by HIV-1 has only a modest effect on the expression of cellular miRNAs at early times after infection. Comprehensive analysis of miRNA binding to the HIV-1 genome using the photoactivatable ribonucleoside-induced cross-linking and immunoprecipitation (PAR-CLIP) technique revealed several binding sites for cellular miRNAs, a subset of which were shown to be capable of mediating miRNA-mediated repression of gene expression. However, the main finding from this analysis is that HIV-1 transcripts are largely refractory to miRNA binding, most probably due to extensive viral RNA secondary structure. Together, these data demonstrate that HIV-1 neither encodes viral miRNAs nor strongly influences cellular miRNA expression, at least early after infection, and imply that HIV-1 transcripts have evolved to avoid inhibition by preexisting cellular miRNAs by adopting extensive RNA secondary structures that occlude most potential miRNA binding sites. IMPORTANCE: MicroRNAs (miRNAs) are a ubiquitous class of small regulatory RNAs that serve as posttranscriptional regulators of gene expression. Previous work has suggested that HIV-1 might subvert the function of the cellular miRNA machinery by expressing viral miRNAs or by dramatically altering the level of cellular miRNA expression. Using very sensitive approaches, we now demonstrate that neither of these ideas is in fact correct. Moreover, HIV-1 transcripts appear to largely avoid regulation by cellular miRNAs by adopting an extensive RNA secondary structure that occludes the ability of cellular miRNAs to interact with viral mRNAs. Together, these data suggest that HIV-1, rather than seeking to control miRNA function in infected cells, has instead evolved a mechanism to become largely invisible to cellular miRNA effector mechanisms.
LinkOut: [PMID: 23592263]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HCT116
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in ERX177609. RNA binding protein: AGO2. Condition:KO_D_AGO_CLIP_2_11 ...

- Krell J; Stebbing J; Carissimi C; Dabrowska et al., 2016, Genome research.

Article - Krell J; Stebbing J; Carissimi C; Dabrowska et al.
- Genome research, 2016
DNA damage activates TP53-regulated surveillance mechanisms that are crucial in suppressing tumorigenesis. TP53 orchestrates these responses directly by transcriptionally modulating genes, including microRNAs (miRNAs), and by regulating miRNA biogenesis through interacting with the DROSHA complex. However, whether the association between miRNAs and AGO2 is regulated following DNA damage is not yet known. Here, we show that, following DNA damage, TP53 interacts with AGO2 to induce or reduce AGO2's association of a subset of miRNAs, including multiple let-7 family members. Furthermore, we show that specific mutations in TP53 decrease rather than increase the association of let-7 family miRNAs, reducing their activity without preventing TP53 from interacting with AGO2. This is consistent with the oncogenic properties of these mutants. Using AGO2 RIP-seq and PAR-CLIP-seq, we show that the DNA damage-induced increase in binding of let-7 family members to the RISC complex is functional. We unambiguously determine the global miRNA-mRNA interaction networks involved in the DNA damage response, validating them through the identification of miRNA-target chimeras formed by endogenous ligation reactions. We find that the target complementary region of the let-7 seed tends to have highly fixed positions and more variable ones. Additionally, we observe that miRNAs, whose cellular abundance or differential association with AGO2 is regulated by TP53, are involved in an intricate network of regulatory feedback and feedforward circuits. TP53-mediated regulation of AGO2-miRNA interaction represents a new mechanism of miRNA regulation in carcinogenesis.
LinkOut: [PMID: 26701625]
CLIP-seq Support 1 for dataset GSM1462574
Method / RBP PAR-CLIP / AGO2
Cell line / Condition TZM-bl / TZM-bl ami BaL
Location of target site ENST00000395290.2 | 3UTR | ACCAUGCACUUCUCUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23592263 / GSE59944
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
68 hsa-miR-6511a-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT059267 CELF1 CUGBP Elav-like family member 1 2 2
MIRT061286 IPO7 importin 7 2 2
MIRT115532 MAZ MYC associated zinc finger protein 2 2
MIRT345985 BIRC5 baculoviral IAP repeat containing 5 2 8
MIRT379535 HNRNPK heterogeneous nuclear ribonucleoprotein K 2 2
MIRT442492 RBBP5 RB binding protein 5, histone lysine methyltransferase complex subunit 2 8
MIRT443702 HUNK hormonally up-regulated Neu-associated kinase 2 4
MIRT459168 HSPA6 heat shock protein family A (Hsp70) member 6 2 21
MIRT497180 ZBTB40 zinc finger and BTB domain containing 40 2 2
MIRT497847 GATA6 GATA binding protein 6 2 4
MIRT519626 ZNF781 zinc finger protein 781 2 2
MIRT519839 ZFP69B ZFP69 zinc finger protein B 2 4
MIRT528561 DNAAF3 dynein axonemal assembly factor 3 2 2
MIRT530719 ORMDL3 ORMDL sphingolipid biosynthesis regulator 3 2 2
MIRT530812 GPR182 G protein-coupled receptor 182 2 2
MIRT533266 VAV3 vav guanine nucleotide exchange factor 3 2 4
MIRT533727 TMEM246 transmembrane protein 246 2 2
MIRT535548 P2RY2 purinergic receptor P2Y2 2 2
MIRT536020 MCUR1 mitochondrial calcium uniporter regulator 1 2 2
MIRT539495 ACTN4 actinin alpha 4 2 2
MIRT541794 MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 2 8
MIRT554510 RUNX1T1 RUNX1 translocation partner 1 2 2
MIRT558785 CEP55 centrosomal protein 55 2 2
MIRT560014 ZNF525 zinc finger protein 525 2 2
MIRT560079 ZNF195 zinc finger protein 195 2 2
MIRT570136 IL1RL2 interleukin 1 receptor like 2 2 2
MIRT570891 ZNF780A zinc finger protein 780A 2 2
MIRT607973 SNX22 sorting nexin 22 2 2
MIRT608105 CRISPLD2 cysteine rich secretory protein LCCL domain containing 2 2 2
MIRT610472 ADAMTS13 ADAM metallopeptidase with thrombospondin type 1 motif 13 2 4
MIRT611135 GGT7 gamma-glutamyltransferase 7 2 2
MIRT611449 NRIP3 nuclear receptor interacting protein 3 2 2
MIRT613020 GABPB1 GA binding protein transcription factor beta subunit 1 2 4
MIRT615754 C6 complement C6 2 2
MIRT632249 VPS41 VPS41, HOPS complex subunit 2 2
MIRT636100 ZDHHC22 zinc finger DHHC-type containing 22 2 2
MIRT637453 ZNF324B zinc finger protein 324B 2 2
MIRT638928 CALCOCO2 calcium binding and coiled-coil domain 2 2 2
MIRT646769 WDR3 WD repeat domain 3 2 2
MIRT652611 TIMM8A translocase of inner mitochondrial membrane 8A 2 2
MIRT652869 TAB1 TGF-beta activated kinase 1 (MAP3K7) binding protein 1 2 2
MIRT653656 SLC27A4 solute carrier family 27 member 4 2 2
MIRT657090 JMY junction mediating and regulatory protein, p53 cofactor 2 2
MIRT657885 GFPT1 glutamine--fructose-6-phosphate transaminase 1 2 2
MIRT662920 MED18 mediator complex subunit 18 2 2
MIRT685623 C12orf49 chromosome 12 open reading frame 49 2 2
MIRT687428 NRIP1 nuclear receptor interacting protein 1 2 2
MIRT692305 CNNM3 cyclin and CBS domain divalent metal cation transport mediator 3 2 2
MIRT695128 PRY2 PTPN13-like, Y-linked 2 2 2
MIRT695145 PRY PTPN13-like, Y-linked 2 2
MIRT696287 IER3IP1 immediate early response 3 interacting protein 1 2 2
MIRT699351 SLC35E1 solute carrier family 35 member E1 2 2
MIRT709902 AGO1 argonaute 1, RISC catalytic component 2 2
MIRT710878 SLC25A42 solute carrier family 25 member 42 2 2
MIRT711366 MED7 mediator complex subunit 7 2 2
MIRT711445 FRMPD3 FERM and PDZ domain containing 3 2 2
MIRT713222 RCAN2 regulator of calcineurin 2 2 2
MIRT713282 LAIR1 leukocyte associated immunoglobulin like receptor 1 2 2
MIRT714196 TRAF7 TNF receptor associated factor 7 2 2
MIRT715153 IL12B interleukin 12B 2 2
MIRT719198 CASP10 caspase 10 2 2
MIRT719470 SRF serum response factor 2 2
MIRT720198 MPP6 membrane palmitoylated protein 6 2 2
MIRT720450 SLC16A5 solute carrier family 16 member 5 2 2
MIRT720462 RAB31 RAB31, member RAS oncogene family 2 2
MIRT721647 ZNF207 zinc finger protein 207 2 2
MIRT722002 CLLU1OS chronic lymphocytic leukemia up-regulated 1 opposite strand 2 2
MIRT725522 FAM229B family with sequence similarity 229 member B 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-6511a-3p Gefitinib 123631 NSC715055 approved resistant cell line (PC9)
hsa-miR-6511a-3p Gefitinib 123631 NSC715055 approved sensitive cell line (HCC827)
hsa-miR-6511a-3p Osimertinib 71496458 NSC779217 approved resistant cell line (PC9)
hsa-miR-6511a-3p Tripterygium wilfordii Hook F resistant tissue
hsa-miR-6511a-3p Cisplatin 5460033 NSC119875 approved resistant cell line (A549)
hsa-miR-6511a-3p Gemcitabine 60750 NSC613327 approved resistant cell line (PANC-1) (1500 ng/ml)

Error report submission