miRTarBase - #MIRT060504


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pre-miRNA Information
pre-miRNA hsa-mir-519c   
Genomic Coordinates chr19: 53686469 - 53686555
Description Homo sapiens miR-519c stem-loop
Comment The 5' arm of this precursor expresses a product related to miR-526 (previously named miR-526c here). Landgraf et al. confirm mature miRNA expression from both arms of the precursor .
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-519c-3p
Sequence 54| AAAGUGCAUCUUUUUAGAGGAU |75
Evidence Experimental
Experiments Array-cloned
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 2 19 + 53686523 29233923 MiREDiBase
A-to-I 3 19 + 53686524 29233923 MiREDiBase
A-to-I 8 19 + 53686529 29233923 MiREDiBase
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1164669230 4 dbSNP
rs764425172 8 dbSNP
rs1377433094 10 dbSNP
rs751997873 19 dbSNP
Putative Targets

miRNA Expression profile
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol PPP6R3   
Synonyms C11orf23, PP6R3, SAP190, SAPL, SAPLa, SAPS3
Description protein phosphatase 6 regulatory subunit 3
Transcript NM_001164160   
Other Transcripts NM_001164161 , NM_001164162 , NM_001164163 , NM_001164164 , NM_018312   
Expression
Putative miRNA Targets on PPP6R3
3'UTR of PPP6R3
(miRNA target sites are highlighted)		 
>PPP6R3|NM_001164160|3'UTR
   1 CGGGTGACGTCTGCTGCTGCTGACTGAGGACTGCAGACCGCCACCACTCAGGGGCTCTGGAGGGGTCAGCTGGAGCCCAC
  81 CAAGCTGTCACTGCTGCACTCACTCTGCAAGGGATCAGGACCAGCAACCTTTATATTCTAGATTCTAAGACATTGTACAG
 161 AGAAATTCAGAAGTGTAAAAATATTGCACATTGACAAATACCAAGAATTTTTGCGTATGTTTATATTGTATTGTTCTAAA
 241 TAATGGGTAGCCTGTGAAATAAGATCTTGCCACCCATGTAATAATAGTAGTAATACTATAGTTAAAATGGCTGTAAGAAT
 321 AGTTTTATAAAAGTGAATACACAGATCTATTGTATTTGAAACATAACTTTGACAATTATTAGTGTGACCAAAGTATTAGG
 401 CGGTTTTCATACATTTTTCACCTTGTACAAAATTATGAATTCATTTTTCCTCCAGGCCGACAAGGAGTTGTAGAATGAAA
 481 ATGCCCTCTAAGTGTTATTTTGGTTGTTCTAACTTACAAAAGTGATTTTGAATAAGAAATATTTGGTGTTCTTTTTATAA
 561 CCAGTTTTTGATTGGTAATTGTTTTCTGTATTGTTTAAAACGGATCAAAAATGTAAGTCTATTGGTAGAGATTAAGTAAA
 641 GTATTTATTGCTACATCATAGTTGATAAATTGATGTTATCGTAAAGCCATATGTTCTGTTCAAGTCTTGTTTGCTTGAAA
 721 TGATTATTCCTACAAGTGAAACACTAGACTATTTGGAGTGTATATGGCTTGTGTTTTGGGATTTTTTTTTTTTTTTTTTG
 801 GCTTTTGTTTTTGTTTGTTTTTTTGTTTCATTTGGTAGTTCATCTGCCTTTTAACCCATTCACCAAAATTTACCTTGTTA
 881 ACAAGCATCACCAATGAACATTTCAGAGCAATCTGCATATTTAACAGACCTAAAATAAATCCTATTAGGCAAGTCAGTTG
 961 AAAATGCTCGTGCTGCTAATGGAATTAGAGTGCGTTCATTTTACAGGCTAGTATTTTAAAAGTAGAAATCAAAATCTGGC
1041 ACCGAAGCATGCTAATTGTTTACTGTACCTTGTGAGGTTTTCACTCATAAATTTAAACCAGTGTATTTTTTTAGAACTGG
1121 TTTGTGTATATATATAGTGATTATGGATACTAATTCAATGTAATTTATAATTTTCTATGTCAATACAAAAATACATCACA
1201 GCCTTCTCAAACAGCTCAAGCAATATATTGTATATTGCCATATCGTCTGGTGAAAGGGTTAAATTACTTCACCTCTTGCA
1281 CTTTTAGATGCAAATCAGTTTTTCATTTCTGTAATAGAAAATTATTCACGTATTTTTACATCATTTGTTTTTCCTGACCA
1361 GTATTTAAAACCAAAAGGATATTCTGAAAAATGGCCAACAATTTTTTTAGAAGTAGCATCCCAAGCAGCGTGCCTAAACA
1441 TTACATTGCATATGGAAATAAAAGAATCAAACGTCTAATGCCTTATTATTTCTGATTTCCTTTTTCATTTTAAGTGGTGT
1521 GGAGATTCCAGCACTCCCAGGACAGTGGAGTCAGCAGTAAGCCCTGGGACAGGTGGCAAGGGTGGGTCCCTTGACCTTTG
1601 CACGCCTCCTCAGGAACCCCCTTTCCCGGGTGAGCCCCTCTCTGAAGAGACTGTCCTTGGGCCTCCTCTGGAAGCAGCAC
1681 CCCCAGAGGACAGGGCTCCTCCTGCTTGCCTCAGGGCTGCCTGACTTGAATGGCGTTGGACCTCGGGGATTACTGGTAGA
1761 TAATATGCTCTGGTCTCGCCTGGTGGTGAGTTTTGCCAGCCATGGCCAGGGTTTGGCTCCACTGGTGGCACACGTGGCCT
1841 CCGTGGTATGGACCTGGTGGCTTCTCCATCCCACTGTGGCCTCTGTGGTATGGACCTGGTGGCTTCTCCATCCTACCCAA
1921 GGTAACAGTGTCTTGCTTCATCCCACTGACTGCTGGGAGAGAGCCTCTGGGACTTTTCTTTGGGGCATCATTTTGTTTTG
2001 TCTTTCGTAGCAGGGAAAGGATATGACAATGGGGAGGACAGTTCTTTTGGAGGTTGGAGGGGCCAAGCCAAGGACAGGAG
2081 CAAGTGTGCCCTCATTTTGTTTCTACTTTTAATTTCTGTGTGTTGGCCATACTGAATTATGAGACTAACAGATGTCTACA
2161 ATACAATACCTGTATTCAAAATAACAAAAATAAAGCCTGATTCTTTGTTTCTAGAAAAAAAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' uaGGAGAUUUUUCUACGUGAAa 5'
            |||||       ||||||| 
Target 5' caCCTCT-------TGCACTTt 3'
 1270 - 1284 145.00 -13.91
2 
miRNA  3' uaggAGAUUUUUCU-ACGUGAAa 5'
              | |||||| | ||||| | 
Target 5' gaagTGTAAAAATATTGCACATt 3'
 170 - 192 134.00 -5.92
3 
miRNA  3' uaGGAGAUUUUUCU-ACGUGAAa 5'
            :||||:||:||| ||: ||| 
Target 5' ccTCTCTGAAGAGACTGTCCTTg 3'
 1637 - 1659 132.00 -15.40
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN26990237 2 COSMIC
COSN26990235 3 COSMIC
COSN13345689 10 COSMIC
COSN26990232 41 COSMIC
COSN30185739 47 COSMIC
COSN31593262 67 COSMIC
COSN30098657 76 COSMIC
COSN31524154 97 COSMIC
COSN21234654 195 COSMIC
COSN31606783 209 COSMIC
COSN31571853 211 COSMIC
COSN31592674 222 COSMIC
COSN30540801 305 COSMIC
COSN31565921 307 COSMIC
COSN22871829 321 COSMIC
COSN27172450 493 COSMIC
COSN19221244 564 COSMIC
COSN20108451 640 COSMIC
COSN25644332 774 COSMIC
COSN19367656 799 COSMIC
COSN20108453 800 COSMIC
COSN28647806 831 COSMIC
COSN28815310 1088 COSMIC
COSN31532511 1113 COSMIC
COSN31555369 1127 COSMIC
COSN32061626 1192 COSMIC
COSN8584613 1250 COSMIC
COSN20077199 1251 COSMIC
COSN26562014 1259 COSMIC
COSN31486786 1271 COSMIC
COSN21430448 1297 COSMIC
COSN31605056 1300 COSMIC
COSN31608138 1301 COSMIC
COSN30167446 1310 COSMIC
COSN8584614 1325 COSMIC
COSN5828647 1337 COSMIC
COSN22239386 1343 COSMIC
COSN21853849 1375 COSMIC
COSN30110852 1389 COSMIC
COSN30110856 1397 COSMIC
COSN30539964 1429 COSMIC
COSN31586232 1473 COSMIC
COSN19659226 1489 COSMIC
COSN30133311 1495 COSMIC
COSM5675568 1539 COSMIC
COSM1729910 1557 COSMIC
COSN22920867 1568 COSMIC
COSN19659127 1609 COSMIC
COSN30710539 1752 COSMIC
COSN1080393 1784 COSMIC
COSN20092386 1873 COSMIC
COSN20092387 1885 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs139831773 2 dbSNP
rs370939332 3 dbSNP
rs1165636607 4 dbSNP
rs1406420739 8 dbSNP
rs761090518 9 dbSNP
rs766846099 10 dbSNP
rs1365104844 11 dbSNP
rs750146446 11 dbSNP
rs764864994 11 dbSNP
rs754323376 14 dbSNP
rs754481243 18 dbSNP
rs758104482 20 dbSNP
rs980070858 24 dbSNP
rs751410997 25 dbSNP
rs779935953 25 dbSNP
rs764740177 28 dbSNP
rs375536209 34 dbSNP
rs200899276 35 dbSNP
rs187794245 38 dbSNP
rs77945063 40 dbSNP
rs1249687224 41 dbSNP
rs551479590 45 dbSNP
rs570263680 46 dbSNP
rs199787312 50 dbSNP
rs548847459 50 dbSNP
rs1460743753 61 dbSNP
rs917999943 70 dbSNP
rs578013020 76 dbSNP
rs1379436484 84 dbSNP
rs765606333 92 dbSNP
rs928006759 94 dbSNP
rs750850947 104 dbSNP
rs1396260223 111 dbSNP
rs555983198 123 dbSNP
rs1423874548 124 dbSNP
rs574643393 128 dbSNP
rs1383362513 129 dbSNP
rs1165206177 132 dbSNP
rs1445088594 133 dbSNP
rs138664045 137 dbSNP
rs909177332 139 dbSNP
rs941446501 146 dbSNP
rs780724691 148 dbSNP
rs1335814723 153 dbSNP
rs921420894 154 dbSNP
rs1038678527 173 dbSNP
rs1490319702 175 dbSNP
rs1290299460 176 dbSNP
rs1443645539 177 dbSNP
rs1322636038 179 dbSNP
rs1295311720 184 dbSNP
rs934267310 185 dbSNP
rs1281786237 189 dbSNP
rs1354788625 191 dbSNP
rs1233078575 192 dbSNP
rs1403843616 202 dbSNP
rs1274167046 203 dbSNP
rs1051759147 206 dbSNP
rs1196970214 215 dbSNP
rs1426916407 216 dbSNP
rs545199889 216 dbSNP
rs1426092510 218 dbSNP
rs1194469199 220 dbSNP
rs1480182321 224 dbSNP
rs999562992 237 dbSNP
rs1225280445 240 dbSNP
rs1489110900 243 dbSNP
rs1018040577 253 dbSNP
rs553475764 272 dbSNP
rs1308863603 280 dbSNP
rs903500934 285 dbSNP
rs572023522 287 dbSNP
rs1222369500 288 dbSNP
rs149329846 289 dbSNP
rs1184012390 337 dbSNP
rs893597431 339 dbSNP
rs1284654982 343 dbSNP
rs1387225335 346 dbSNP
rs1000567659 347 dbSNP
rs1010651016 350 dbSNP
rs1296222296 353 dbSNP
rs1474815542 353 dbSNP
rs1402727275 368 dbSNP
rs1463388697 368 dbSNP
rs1171573448 373 dbSNP
rs1031665630 374 dbSNP
rs1427232030 374 dbSNP
rs956993402 383 dbSNP
rs992373748 389 dbSNP
rs746674580 394 dbSNP
rs1481862006 396 dbSNP
rs1463782921 400 dbSNP
rs1025064525 402 dbSNP
rs1023499845 403 dbSNP
rs1396686463 410 dbSNP
rs564175101 412 dbSNP
rs1233383247 419 dbSNP
rs1335086613 419 dbSNP
rs1304875004 420 dbSNP
rs1393075421 429 dbSNP
rs981241771 431 dbSNP
rs969188617 450 dbSNP
rs1411167180 458 dbSNP
rs1003477354 459 dbSNP
rs1035317561 460 dbSNP
rs1331568051 462 dbSNP
rs951418579 463 dbSNP
rs1414685120 465 dbSNP
rs1157471287 472 dbSNP
rs1442097343 484 dbSNP
rs1239115390 489 dbSNP
rs1183395989 490 dbSNP
rs1459672868 494 dbSNP
rs1257915211 497 dbSNP
rs752192400 498 dbSNP
rs755684639 499 dbSNP
rs1200532686 501 dbSNP
rs777209468 506 dbSNP
rs1294352506 509 dbSNP
rs909326788 510 dbSNP
rs1354365115 511 dbSNP
rs1357755193 512 dbSNP
rs1243562161 518 dbSNP
rs1336472437 519 dbSNP
rs1396829903 531 dbSNP
rs1384271022 535 dbSNP
rs543811056 539 dbSNP
rs1250986627 543 dbSNP
rs972129905 547 dbSNP
rs909879266 552 dbSNP
rs919262123 557 dbSNP
rs962798075 560 dbSNP
rs1187746725 567 dbSNP
rs1446090889 569 dbSNP
rs1259010405 579 dbSNP
rs929842679 584 dbSNP
rs1488564190 586 dbSNP
rs1291021761 592 dbSNP
rs773227908 602 dbSNP
rs1485330505 603 dbSNP
rs760607619 607 dbSNP
rs1259429180 613 dbSNP
rs576670161 613 dbSNP
rs1401974146 614 dbSNP
rs942571441 616 dbSNP
rs1303008682 620 dbSNP
rs560274784 622 dbSNP
rs1393268127 623 dbSNP
rs878888038 633 dbSNP
rs398097595 634 dbSNP
rs60926083 634 dbSNP
rs1371035588 635 dbSNP
rs1000939835 639 dbSNP
rs112346857 642 dbSNP
rs1030585902 645 dbSNP
rs1267561858 654 dbSNP
rs1051358043 659 dbSNP
rs544026541 660 dbSNP
rs892140535 663 dbSNP
rs752291529 674 dbSNP
rs1195047214 675 dbSNP
rs1338953980 681 dbSNP
rs193207880 682 dbSNP
rs1220705489 693 dbSNP
rs376280973 697 dbSNP
rs1282757307 700 dbSNP
rs1403597787 704 dbSNP
rs185231308 705 dbSNP
rs370699254 709 dbSNP
rs1333374936 711 dbSNP
rs1052563818 717 dbSNP
rs1409811728 721 dbSNP
rs1393873104 726 dbSNP
rs770517656 731 dbSNP
rs778717055 733 dbSNP
rs1172288420 739 dbSNP
rs1170349661 750 dbSNP
rs1013764044 753 dbSNP
rs7481228 755 dbSNP
rs1196686974 761 dbSNP
rs1478949505 763 dbSNP
rs1247264439 764 dbSNP
rs1025199231 765 dbSNP
rs1200710195 766 dbSNP
rs969946801 772 dbSNP
rs1434714791 774 dbSNP
rs1010680430 778 dbSNP
rs1181344399 779 dbSNP
rs147261748 781 dbSNP
rs11309470 782 dbSNP
rs1173601588 782 dbSNP
rs1384168002 782 dbSNP
rs1404948292 782 dbSNP
rs1415735609 782 dbSNP
rs1447011063 782 dbSNP
rs1491179179 782 dbSNP
rs56800713 782 dbSNP
rs767970507 782 dbSNP
rs773141546 782 dbSNP
rs796900974 782 dbSNP
rs1425775549 787 dbSNP
rs1314030847 795 dbSNP
rs1377741032 797 dbSNP
rs1380910451 798 dbSNP
rs1157872972 799 dbSNP
rs1295258292 799 dbSNP
rs1239733733 800 dbSNP
rs1468560061 800 dbSNP
rs979588033 801 dbSNP
rs1327285616 802 dbSNP
rs879223991 803 dbSNP
rs1002409374 804 dbSNP
rs1229854180 804 dbSNP
rs796155764 808 dbSNP
rs1279436994 809 dbSNP
rs1223667717 810 dbSNP
rs1352188304 810 dbSNP
rs1273210699 811 dbSNP
rs878878093 814 dbSNP
rs1016758820 815 dbSNP
rs1282401628 816 dbSNP
rs370918342 816 dbSNP
rs1449797812 818 dbSNP
rs917920969 818 dbSNP
rs1487238933 819 dbSNP
rs929292105 826 dbSNP
rs1262143187 829 dbSNP
rs1398852131 829 dbSNP
rs1448432564 830 dbSNP
rs3740628 831 dbSNP
rs1196302217 835 dbSNP
rs188596705 838 dbSNP
rs1473910386 842 dbSNP
rs1454346341 845 dbSNP
rs1174923319 846 dbSNP
rs905037940 856 dbSNP
rs1397464153 865 dbSNP
rs1003749630 876 dbSNP
rs1288852916 881 dbSNP
rs1217797122 882 dbSNP
rs192758511 883 dbSNP
rs919228037 889 dbSNP
rs1229640785 890 dbSNP
rs1379497820 892 dbSNP
rs951409392 893 dbSNP
rs1269059642 895 dbSNP
rs1397661472 896 dbSNP
rs1362376264 904 dbSNP
rs1298663170 910 dbSNP
rs1347851727 915 dbSNP
rs1288703887 925 dbSNP
rs1166692464 936 dbSNP
rs1425748108 940 dbSNP
rs1386112384 941 dbSNP
rs1004121606 942 dbSNP
rs1185988235 943 dbSNP
rs771929509 943 dbSNP
rs1370451523 944 dbSNP
rs986695784 945 dbSNP
rs759209411 951 dbSNP
rs975481289 953 dbSNP
rs533155403 954 dbSNP
rs551419966 968 dbSNP
rs569807905 970 dbSNP
rs942521451 971 dbSNP
rs1305669749 982 dbSNP
rs1216417829 983 dbSNP
rs1271934572 983 dbSNP
rs1341773369 988 dbSNP
rs1315097155 994 dbSNP
rs1404216250 995 dbSNP
rs1238228389 1000 dbSNP
rs1365452392 1003 dbSNP
rs1295046945 1021 dbSNP
rs4988291 1023 dbSNP
rs1352578731 1025 dbSNP
rs184154067 1041 dbSNP
rs1207786409 1042 dbSNP
rs987412003 1043 dbSNP
rs73508104 1044 dbSNP
rs1468613072 1045 dbSNP
rs1171531432 1048 dbSNP
rs936401006 1049 dbSNP
rs1235802743 1051 dbSNP
rs934934874 1055 dbSNP
rs1159007515 1056 dbSNP
rs990380817 1058 dbSNP
rs1232680017 1059 dbSNP
rs1196313578 1061 dbSNP
rs1319592358 1064 dbSNP
rs1258106213 1065 dbSNP
rs1222422702 1068 dbSNP
rs144583050 1069 dbSNP
rs1303401720 1070 dbSNP
rs139467236 1077 dbSNP
rs1372266433 1078 dbSNP
rs946333458 1093 dbSNP
rs1044841576 1097 dbSNP
rs1163164438 1102 dbSNP
rs140103060 1106 dbSNP
rs1402796210 1121 dbSNP
rs749196576 1123 dbSNP
rs1465665862 1127 dbSNP
rs546437384 1127 dbSNP
rs1046623582 1129 dbSNP
rs1434277404 1133 dbSNP
rs1380032089 1136 dbSNP
rs1177201354 1143 dbSNP
rs1458798873 1145 dbSNP
rs905482326 1161 dbSNP
rs1202475136 1163 dbSNP
rs1481948524 1167 dbSNP
rs904982839 1172 dbSNP
rs1002872081 1176 dbSNP
rs1390826510 1180 dbSNP
rs373571700 1182 dbSNP
rs939107030 1184 dbSNP
rs1306782593 1193 dbSNP
rs762056496 1194 dbSNP
rs1379394425 1200 dbSNP
rs886928897 1203 dbSNP
rs1332218515 1216 dbSNP
rs1337414097 1222 dbSNP
rs1004556748 1223 dbSNP
rs752252870 1228 dbSNP
rs1304694722 1229 dbSNP
rs1016776897 1233 dbSNP
rs1360500705 1235 dbSNP
rs1335134532 1237 dbSNP
rs1442004865 1238 dbSNP
rs1215159289 1241 dbSNP
rs765401727 1245 dbSNP
rs111277924 1246 dbSNP
rs551606026 1251 dbSNP
rs762389522 1251 dbSNP
rs996763448 1258 dbSNP
rs554057626 1259 dbSNP
rs1480026249 1260 dbSNP
rs1283882931 1267 dbSNP
rs572024779 1268 dbSNP
rs1354079211 1271 dbSNP
rs955674878 1272 dbSNP
rs144982350 1275 dbSNP
rs1032278969 1282 dbSNP
rs1244285298 1306 dbSNP
rs1338965122 1307 dbSNP
rs1314911105 1312 dbSNP
rs1421357440 1313 dbSNP
rs956205370 1315 dbSNP
rs990410397 1316 dbSNP
rs914789896 1322 dbSNP
rs948950069 1330 dbSNP
rs963958117 1331 dbSNP
rs1462227414 1333 dbSNP
rs763418405 1335 dbSNP
rs1167380545 1348 dbSNP
rs1361513476 1349 dbSNP
rs980467220 1351 dbSNP
rs1456046589 1355 dbSNP
rs766920719 1357 dbSNP
rs1187639856 1361 dbSNP
rs1352923017 1378 dbSNP
rs926296417 1393 dbSNP
rs1260429320 1402 dbSNP
rs939122847 1411 dbSNP
rs550276001 1423 dbSNP
rs755489902 1426 dbSNP
rs557832622 1430 dbSNP
rs1052116984 1431 dbSNP
rs1207892861 1435 dbSNP
rs1438309151 1439 dbSNP
rs1354489253 1441 dbSNP
rs1245800452 1444 dbSNP
rs1292506740 1444 dbSNP
rs1339855838 1445 dbSNP
rs1276406751 1447 dbSNP
rs371872691 1449 dbSNP
rs779351570 1450 dbSNP
rs1323300415 1453 dbSNP
rs1393339348 1456 dbSNP
rs913687204 1456 dbSNP
rs763617085 1463 dbSNP
rs1269771436 1467 dbSNP
rs576183049 1469 dbSNP
rs1198437605 1470 dbSNP
rs117902029 1473 dbSNP
rs188435298 1474 dbSNP
rs1190987269 1476 dbSNP
rs112362886 1477 dbSNP
rs1371978612 1479 dbSNP
rs1172243859 1481 dbSNP
rs1457988762 1482 dbSNP
rs377534807 1483 dbSNP
rs397843685 1483 dbSNP
rs4988290 1483 dbSNP
rs748238740 1485 dbSNP
rs1453047442 1486 dbSNP
rs748234960 1487 dbSNP
rs1267803580 1489 dbSNP
rs899312081 1495 dbSNP
rs1302913503 1496 dbSNP
rs1341599388 1498 dbSNP
rs1378420547 1498 dbSNP
rs1384394223 1502 dbSNP
rs1294086125 1507 dbSNP
rs1325885817 1508 dbSNP
rs1220611631 1512 dbSNP
rs772463503 1513 dbSNP
rs1340676525 1514 dbSNP
rs1294150530 1526 dbSNP
rs1008745150 1528 dbSNP
rs1274715478 1529 dbSNP
rs1357535368 1531 dbSNP
rs111503828 1535 dbSNP
rs1026395624 1537 dbSNP
rs1489177782 1540 dbSNP
rs566717955 1541 dbSNP
rs956407871 1545 dbSNP
rs761145593 1547 dbSNP
rs1423823572 1549 dbSNP
rs1445545560 1551 dbSNP
rs766729090 1553 dbSNP
rs1397736494 1555 dbSNP
rs1382920531 1562 dbSNP
rs758978317 1565 dbSNP
rs1465748916 1567 dbSNP
rs890585721 1574 dbSNP
rs1170682287 1576 dbSNP
rs770058779 1580 dbSNP
rs990358001 1580 dbSNP
rs1374198318 1582 dbSNP
rs1158919162 1586 dbSNP
rs1361513312 1588 dbSNP
rs541313410 1597 dbSNP
rs1021796289 1600 dbSNP
rs1291012775 1602 dbSNP
rs766743342 1604 dbSNP
rs778540471 1605 dbSNP
rs1317246206 1608 dbSNP
rs12941 1609 dbSNP
rs533483930 1612 dbSNP
rs1217937425 1613 dbSNP
rs555734486 1617 dbSNP
rs1432855947 1620 dbSNP
rs567415428 1628 dbSNP
rs758174820 1629 dbSNP
rs142423866 1631 dbSNP
rs939771417 1633 dbSNP
rs1038198916 1635 dbSNP
rs779871299 1640 dbSNP
rs987972452 1643 dbSNP
rs1416411608 1648 dbSNP
rs913739534 1649 dbSNP
rs1458223961 1650 dbSNP
rs1245492386 1652 dbSNP
rs1437521965 1655 dbSNP
rs752241096 1659 dbSNP
rs757878331 1662 dbSNP
rs1213392350 1667 dbSNP
rs1236649159 1670 dbSNP
rs777838665 1670 dbSNP
rs981838992 1675 dbSNP
rs749565613 1680 dbSNP
rs763756453 1681 dbSNP
rs1202178428 1682 dbSNP
rs926283152 1684 dbSNP
rs1444624048 1686 dbSNP
rs1281747353 1688 dbSNP
rs751170820 1689 dbSNP
rs757005388 1691 dbSNP
rs1178818568 1692 dbSNP
rs1351888704 1695 dbSNP
rs759226468 1696 dbSNP
rs1381781635 1697 dbSNP
rs932592759 1699 dbSNP
rs1223952343 1700 dbSNP
rs1421190499 1702 dbSNP
rs1378036661 1706 dbSNP
rs1414211808 1711 dbSNP
rs1157355775 1722 dbSNP
rs1449674478 1723 dbSNP
rs1355550569 1728 dbSNP
rs563372709 1735 dbSNP
rs746919664 1736 dbSNP
rs1008191312 1737 dbSNP
rs1339327439 1740 dbSNP
rs1403939420 1742 dbSNP
rs1053528566 1743 dbSNP
rs530899398 1744 dbSNP
rs1159070089 1745 dbSNP
rs768508729 1745 dbSNP
rs780109560 1746 dbSNP
rs116021975 1747 dbSNP
rs1312603765 1759 dbSNP
rs1193512797 1760 dbSNP
rs772231527 1760 dbSNP
rs113019159 1761 dbSNP
rs535323768 1761 dbSNP
rs1261208258 1763 dbSNP
rs778173796 1764 dbSNP
rs748191206 1766 dbSNP
rs1234166959 1767 dbSNP
rs1035910509 1772 dbSNP
rs1176307187 1774 dbSNP
rs960654299 1775 dbSNP
rs1250230862 1776 dbSNP
rs372198942 1778 dbSNP
rs771216559 1779 dbSNP
rs1347904803 1781 dbSNP
rs961138149 1781 dbSNP
rs1427822980 1782 dbSNP
rs1469304962 1783 dbSNP
rs1171464761 1787 dbSNP
rs556237961 1788 dbSNP
rs1440256729 1790 dbSNP
rs1170107596 1800 dbSNP
rs1280574991 1804 dbSNP
rs1297873085 1806 dbSNP
rs1477113706 1812 dbSNP
rs180906394 1818 dbSNP
rs957909225 1823 dbSNP
rs1245370230 1824 dbSNP
rs1281235980 1826 dbSNP
rs1322710390 1827 dbSNP
rs1219244645 1831 dbSNP
rs1256210555 1834 dbSNP
rs769996586 1835 dbSNP
rs1216320474 1836 dbSNP
rs1020715264 1839 dbSNP
rs759904923 1843 dbSNP
rs932456719 1843 dbSNP
rs1203318675 1844 dbSNP
rs1218588766 1845 dbSNP
rs970550662 1846 dbSNP
rs1295100726 1853 dbSNP
rs1443333190 1854 dbSNP
rs529088918 1855 dbSNP
rs1395551539 1858 dbSNP
rs183597138 1861 dbSNP
rs1464193886 1864 dbSNP
rs912521715 1865 dbSNP
rs937682931 1867 dbSNP
rs1267283642 1871 dbSNP
rs1480395711 1872 dbSNP
rs770377200 1874 dbSNP
rs943946863 1875 dbSNP
rs189542273 1880 dbSNP
rs775925201 1881 dbSNP
rs891783605 1882 dbSNP
rs1408304566 1884 dbSNP
rs1011687549 1885 dbSNP
rs113945723 1886 dbSNP
rs1043134592 1888 dbSNP
rs1350695300 1890 dbSNP
rs376806352 1892 dbSNP
rs973519014 1896 dbSNP
rs906039708 1897 dbSNP
rs1001670246 1913 dbSNP
rs1400509432 1914 dbSNP
rs1271879595 1916 dbSNP
rs1359202253 1921 dbSNP
rs1213482722 1922 dbSNP
rs1446370552 1923 dbSNP
rs929512389 1928 dbSNP
rs59291393 1929 dbSNP
rs78069174 1933 dbSNP
rs1218529634 1934 dbSNP
rs1219886130 1948 dbSNP
rs1290008247 1951 dbSNP
rs1490303992 1953 dbSNP
rs1217073808 1954 dbSNP
rs772572062 1956 dbSNP
rs1308712388 1962 dbSNP
rs778937286 1970 dbSNP
rs1185988240 1972 dbSNP
rs1386009898 1973 dbSNP
rs1005529905 1975 dbSNP
rs57625555 1976 dbSNP
rs1465964301 1978 dbSNP
rs900619644 1984 dbSNP
rs767071024 1985 dbSNP
rs1420110935 1990 dbSNP
rs1320130495 2003 dbSNP
rs1343378989 2005 dbSNP
rs1996 2007 dbSNP
rs555440756 2008 dbSNP
rs574107030 2010 dbSNP
rs1243296174 2011 dbSNP
rs1313958716 2019 dbSNP
rs1359125461 2021 dbSNP
rs891809872 2022 dbSNP
rs1180824472 2028 dbSNP
rs1026653801 2030 dbSNP
rs1482227732 2031 dbSNP
rs1208527103 2034 dbSNP
rs1224695940 2035 dbSNP
rs541603034 2036 dbSNP
rs1445766947 2038 dbSNP
rs1215753049 2043 dbSNP
rs1337806613 2045 dbSNP
rs753788021 2048 dbSNP
rs758560015 2053 dbSNP
rs553194973 2054 dbSNP
rs1384850913 2061 dbSNP
rs182261946 2062 dbSNP
rs1435906158 2066 dbSNP
rs943993232 2073 dbSNP
rs1360239264 2078 dbSNP
rs545331054 2081 dbSNP
rs368324749 2082 dbSNP
rs758541647 2083 dbSNP
rs1003819628 2087 dbSNP
rs1333026194 2090 dbSNP
rs1033430356 2094 dbSNP
rs1186218705 2103 dbSNP
rs913250243 2108 dbSNP
rs1453415845 2110 dbSNP
rs973186164 2112 dbSNP
rs920231705 2115 dbSNP
rs760840944 2117 dbSNP
rs766830713 2130 dbSNP
rs186927657 2132 dbSNP
rs1415380618 2135 dbSNP
rs1474716871 2140 dbSNP
rs73508108 2141 dbSNP
rs1319949873 2146 dbSNP
rs1392356728 2146 dbSNP
rs1295230743 2149 dbSNP
rs1407732069 2150 dbSNP
rs1296722947 2155 dbSNP
rs944886169 2156 dbSNP
rs1162216833 2157 dbSNP
rs1456095791 2157 dbSNP
rs905985700 2165 dbSNP
rs572335407 2173 dbSNP
rs936055275 2174 dbSNP
rs1195248586 2180 dbSNP
rs561444717 2186 dbSNP
rs777927518 2186 dbSNP
rs1266437765 2188 dbSNP
rs151294029 2188 dbSNP
rs1209422790 2202 dbSNP
rs1467340212 2208 dbSNP
rs1275098913 2209 dbSNP
rs891777357 2212 dbSNP
rs1317837319 2215 dbSNP
rs1010219497 2216 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Disease 55291.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM714644. RNA binding protein: AGO2. Condition:completeT1 ...

- Kishore S; Jaskiewicz L; Burger L; Hausser et al., 2011, Nature methods.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' uaGGAGAUUUUUCUACGUGAAa 5'
            |||||       ||||||| 
Target 5' caCCUCU-------UGCACUUu 3'
 		12 - 26
Article - Kishore S; Jaskiewicz L; Burger L; Hausser et al.
- Nature methods, 2011
Cross-linking and immunoprecipitation (CLIP) is increasingly used to map transcriptome-wide binding sites of RNA-binding proteins. We developed a method for CLIP data analysis, and applied it to compare CLIP with photoactivatable ribonucleoside-enhanced CLIP (PAR-CLIP) and to uncover how differences in cross-linking and ribonuclease digestion affect the identified sites. We found only small differences in accuracies of these methods in identifying binding sites of HuR, which binds low-complexity sequences, and Argonaute 2, which has a complex binding specificity. We found that cross-link-induced mutations led to single-nucleotide resolution for both PAR-CLIP and CLIP. Our results confirm the expectation from original CLIP publications that RNA-binding proteins do not protect their binding sites sufficiently under the denaturing conditions used during the CLIP procedure, and we show that extensive digestion with sequence-specific RNases strongly biases the recovered binding sites. This bias can be substantially reduced by milder nuclease digestion conditions.
LinkOut: [PMID: 21572407]
CLIP-seq Support 1 for dataset GSM714644
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / completeT1, repA
Location of target site ENST00000393800.2 | 3UTR | UUAAAUUACUUCACCUCUUGCACUUUUAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 21572407 / GSE28865
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE28260 Renal cortex and medulla 0.819 3.1e-4 0.731 2.3e-3 13 Click to see details
GSE42095 Differentiated embryonic stem cells 0.494 8.3e-3 0.499 7.7e-3 23 Click to see details
GSE19350 CNS germ cell tumors 0.522 4.1e-2 0.607 1.8e-2 12 Click to see details
GSE21687 Ependynoma primary tumors -0.184 7.3e-2 -0.098 2.2e-1 64 Click to see details
GSE17306 Multiple myeloma -0.185 1.0e-1 0.420 1.3e-3 49 Click to see details
GSE26953 Aortic valvular endothelial cells -0.236 1.3e-1 -0.140 2.6e-1 24 Click to see details
GSE15076 Monocyte-derived dendritic cells -0.378 1.8e-1 -0.238 2.9e-1 8 Click to see details
GSE28544 Breast cancer -0.157 2.3e-1 -0.302 7.6e-2 24 Click to see details
GSE35602 Colorectal cancer stromal tissue -0.139 2.5e-1 0.280 8.8e-2 25 Click to see details
GSE14794 Lymphoblastoid cells -0.068 2.6e-1 -0.085 2.1e-1 90 Click to see details
GSE38226 Liver fibrosis 0.125 2.9e-1 0.495 1.1e-2 21 Click to see details
GSE27834 Pluripotent stem cells 0.124 3.2e-1 0.303 1.3e-1 16 Click to see details
GSE21849 B cell lymphoma -0.08 3.4e-1 -0.103 3.0e-1 29 Click to see details
GSE17498 Multiple myeloma 0.059 3.6e-1 0.054 3.7e-1 40 Click to see details
GSE32688 Pancreatic cancer -0.065 3.6e-1 -0.117 2.6e-1 32 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis 0.018 4.7e-1 -0.561 5.0e-3 20 Click to see details
GSE38974 Chronic obstructive pulmonary disease 0.014 4.7e-1 0.163 2.2e-1 25 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
HNSC -0.216 0.43 -0.500 0.33 3 Click to see details
LIHC 0.117 0.44 0.200 0.4 4 Click to see details
BRCA 0.044 0.47 -0.100 0.44 5 Click to see details
BRCA 0.044 0.47 -0.100 0.44 5 Click to see details
BRCA 0.044 0.47 -0.100 0.44 5 Click to see details
BRCA 0.044 0.47 -0.100 0.44 5 Click to see details
325 hsa-miR-519c-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT000496 HIF1A hypoxia inducible factor 1 alpha subunit 4 1
MIRT000998 ABCG2 ATP binding cassette subfamily G member 2 (Junior blood group) 4 3
MIRT003732 ELAVL1 ELAV like RNA binding protein 1 3 1
MIRT006639 TIMP2 TIMP metallopeptidase inhibitor 2 3 1
MIRT006640 PTEN phosphatase and tensin homolog 3 1
MIRT006641 CDKN1A cyclin dependent kinase inhibitor 1A 3 1
MIRT055028 TPRG1L tumor protein p63 regulated 1 like 2 2
MIRT055393 SHOC2 SHOC2, leucine rich repeat scaffold protein 2 6
MIRT056828 REEP3 receptor accessory protein 3 2 2
MIRT060504 PPP6R3 protein phosphatase 6 regulatory subunit 3 2 2
MIRT061796 PPP1R15B protein phosphatase 1 regulatory subunit 15B 2 10
MIRT063354 ETNK1 ethanolamine kinase 1 2 2
MIRT064424 ARID4B AT-rich interaction domain 4B 2 2
MIRT064719 CCND2 cyclin D2 2 2
MIRT064805 ZBTB18 zinc finger and BTB domain containing 18 2 4
MIRT065609 DAZAP2 DAZ associated protein 2 2 10
MIRT065622 CLIC4 chloride intracellular channel 4 2 4
MIRT065872 GDF11 growth differentiation factor 11 2 2
MIRT065892 RAB5B RAB5B, member RAS oncogene family 2 8
MIRT068751 RB1 RB transcriptional corepressor 1 2 2
MIRT070050 FANCM Fanconi anemia complementation group M 2 2
MIRT071004 SMOC1 SPARC related modular calcium binding 1 2 2
MIRT071334 CMPK1 cytidine/uridine monophosphate kinase 1 2 6
MIRT071912 ZFYVE9 zinc finger FYVE-type containing 9 2 2
MIRT072732 GLCE glucuronic acid epimerase 2 2
MIRT076028 COX10 COX10, heme A:farnesyltransferase cytochrome c oxidase assembly factor 2 6
MIRT076046 PITPNA phosphatidylinositol transfer protein alpha 2 2
MIRT079353 CCDC137 coiled-coil domain containing 137 2 2
MIRT080227 SMAD4 SMAD family member 4 2 6
MIRT081122 LDLR low density lipoprotein receptor 2 8
MIRT081205 MIDN midnolin 2 10
MIRT085098 IFNAR2 interferon alpha and beta receptor subunit 2 2 6
MIRT085149 SLC5A3 solute carrier family 5 member 3 2 4
MIRT086436 NABP1 nucleic acid binding protein 1 2 6
MIRT088037 UBXN2A UBX domain protein 2A 2 2
MIRT088132 SEPT2 septin 2 2 4
MIRT088343 MAPRE3 microtubule associated protein RP/EB family member 3 2 8
MIRT090645 U2SURP U2 snRNP associated SURP domain containing 2 6
MIRT090805 MBNL1 muscleblind like splicing regulator 1 2 4
MIRT091692 TGFBR2 transforming growth factor beta receptor 2 2 4
MIRT092689 C3ORF38 chromosome 3 open reading frame 38 2 8
MIRT093954 SLAIN2 SLAIN motif family member 2 2 2
MIRT095727 ANKH ANKH inorganic pyrophosphate transport regulator 2 8
MIRT097158 FCHO2 FCH domain only 2 2 2
MIRT099319 QKI QKI, KH domain containing RNA binding 2 4
MIRT099835 SOX4 SRY-box 4 2 10
MIRT100773 ENPP4 ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative) 2 2
MIRT100955 CENPQ centromere protein Q 2 4
MIRT102229 HBP1 HMG-box transcription factor 1 2 2
MIRT102299 DNAJB9 DnaJ heat shock protein family (Hsp40) member B9 2 10
MIRT102621 UBN2 ubinuclein 2 2 8
MIRT103780 PURB purine rich element binding protein B 2 2
MIRT104168 PHTF2 putative homeodomain transcription factor 2 2 6
MIRT107279 FAM73B mitoguardin 2 2 2
MIRT107945 TMEM2 transmembrane protein 2 2 2
MIRT108265 HABP4 hyaluronan binding protein 4 2 2
MIRT124812 BICD2 BICD cargo adaptor 2 2 2
MIRT138707 MPP5 membrane palmitoylated protein 5 2 2
MIRT139880 BTF3L4 basic transcription factor 3 like 4 2 6
MIRT144312 NFAT5 nuclear factor of activated T-cells 5 2 8
MIRT145605 LASP1 LIM and SH3 protein 1 2 2
MIRT153350 MAVS mitochondrial antiviral signaling protein 2 4
MIRT153986 PRNP prion protein 2 2
MIRT159129 NRBP1 nuclear receptor binding protein 1 2 2
MIRT164533 MSMO1 methylsterol monooxygenase 1 2 2
MIRT165912 CREBRF CREB3 regulatory factor 2 2
MIRT170858 TAX1BP1 Tax1 binding protein 1 2 4
MIRT172157 FZD6 frizzled class receptor 6 2 8
MIRT173701 PRPF4 pre-mRNA processing factor 4 2 2
MIRT175003 ZBTB5 zinc finger and BTB domain containing 5 2 4
MIRT175400 ACSL4 acyl-CoA synthetase long chain family member 4 2 2
MIRT178069 SAMD8 sterile alpha motif domain containing 8 2 2
MIRT178675 FAM102B family with sequence similarity 102 member B 2 2
MIRT180847 RPRD2 regulation of nuclear pre-mRNA domain containing 2 2 4
MIRT194911 RBBP6 RB binding protein 6, ubiquitin ligase 2 8
MIRT195755 ATMIN ATM interactor 2 6
MIRT196623 TAOK1 TAO kinase 1 2 6
MIRT205286 STK11IP serine/threonine kinase 11 interacting protein 2 2
MIRT206051 PPARA peroxisome proliferator activated receptor alpha 2 2
MIRT206198 RAB10 RAB10, member RAS oncogene family 2 4
MIRT208980 SKIL SKI like proto-oncogene 2 10
MIRT223637 ATP6V1C1 ATPase H+ transporting V1 subunit C1 2 4
MIRT224757 DPYSL2 dihydropyrimidinase like 2 2 2
MIRT227995 NFIB nuclear factor I B 2 4
MIRT230973 PRRG4 proline rich and Gla domain 4 2 2
MIRT238183 ANKRD33B ankyrin repeat domain 33B 2 10
MIRT242425 HAS3 hyaluronan synthase 3 2 2
MIRT242666 SALL3 spalt like transcription factor 3 2 4
MIRT242765 FNBP1L formin binding protein 1 like 2 6
MIRT243095 LCLAT1 lysocardiolipin acyltransferase 1 2 4
MIRT243437 PAK2 p21 (RAC1) activated kinase 2 2 2
MIRT243964 MAP1B microtubule associated protein 1B 2 2
MIRT244776 RABGAP1 RAB GTPase activating protein 1 2 2
MIRT246630 TMEM109 transmembrane protein 109 2 2
MIRT246968 TSKU tsukushi, small leucine rich proteoglycan 2 2
MIRT266055 FJX1 four jointed box 1 2 4
MIRT266858 SLC25A44 solute carrier family 25 member 44 2 2
MIRT283184 C16ORF52 chromosome 16 open reading frame 52 2 2
MIRT286955 SOCS7 suppressor of cytokine signaling 7 2 2
MIRT293651 PVR poliovirus receptor 2 4
MIRT295178 ZNF317 zinc finger protein 317 2 4
MIRT302453 CLIP4 CAP-Gly domain containing linker protein family member 4 2 2
MIRT303499 NAGK N-acetylglucosamine kinase 2 6
MIRT368755 CDADC1 cytidine and dCMP deaminase domain containing 1 2 2
MIRT383207 APH1A aph-1 homolog A, gamma-secretase subunit 2 2
MIRT383610 POU2F1 POU class 2 homeobox 1 2 2
MIRT396102 CASP2 caspase 2 2 2
MIRT441419 FAM9C family with sequence similarity 9 member C 2 2
MIRT446818 C5orf30 chromosome 5 open reading frame 30 2 2
MIRT448307 WNK3 WNK lysine deficient protein kinase 3 2 2
MIRT461781 MPDU1 mannose-P-dolichol utilization defect 1 2 2
MIRT462816 NTN1 netrin 1 2 2
MIRT463613 ZBTB34 zinc finger and BTB domain containing 34 2 2
MIRT464560 UBTF upstream binding transcription factor, RNA polymerase I 2 2
MIRT464842 RPS27A ribosomal protein S27a 2 12
MIRT465225 TRIP10 thyroid hormone receptor interactor 10 2 2
MIRT466446 TFAM transcription factor A, mitochondrial 2 8
MIRT466836 STX6 syntaxin 6 2 6
MIRT467185 SPTY2D1 SPT2 chromatin protein domain containing 1 2 2
MIRT468179 SGMS1 sphingomyelin synthase 1 2 2
MIRT469850 PXK PX domain containing serine/threonine kinase like 2 8
MIRT471612 PAQR5 progestin and adipoQ receptor family member 5 2 19
MIRT472008 NR1D2 nuclear receptor subfamily 1 group D member 2 2 2
MIRT472159 NIN ninein 2 4
MIRT472336 NETO2 neuropilin and tolloid like 2 2 4
MIRT473162 MLLT1 MLLT1, super elongation complex subunit 2 2
MIRT473623 MARK2 microtubule affinity regulating kinase 2 2 2
MIRT473682 MAPKBP1 mitogen-activated protein kinase binding protein 1 2 2
MIRT473805 MAP3K2 mitogen-activated protein kinase kinase kinase 2 2 2
MIRT474416 KLHL28 kelch like family member 28 2 8
MIRT474736 KIF13A kinesin family member 13A 2 6
MIRT474966 KCTD10 potassium channel tetramerization domain containing 10 2 4
MIRT475464 HSPA8 heat shock protein family A (Hsp70) member 8 2 6
MIRT476120 GPR157 G protein-coupled receptor 157 2 2
MIRT476203 GNS glucosamine (N-acetyl)-6-sulfatase 2 6
MIRT477180 F3 coagulation factor III, tissue factor 2 8
MIRT478103 DLG5 discs large MAGUK scaffold protein 5 2 6
MIRT478713 CSNK1A1 casein kinase 1 alpha 1 2 6
MIRT479055 CNOT6L CCR4-NOT transcription complex subunit 6 like 2 8
MIRT480008 CAPRIN2 caprin family member 2 2 4
MIRT480519 C11orf30 EMSY, BRCA2 interacting transcriptional repressor 2 10
MIRT480822 BLCAP bladder cancer associated protein 2 10
MIRT480944 BBX BBX, HMG-box containing 2 8
MIRT481336 ATL3 atlastin GTPase 3 2 2
MIRT481598 ARHGAP1 Rho GTPase activating protein 1 2 6
MIRT481877 ANKRD50 ankyrin repeat domain 50 2 2
MIRT482471 ADAR adenosine deaminase, RNA specific 2 4
MIRT484875 ZNF652 zinc finger protein 652 2 2
MIRT485090 SLC30A1 solute carrier family 30 member 1 2 4
MIRT485579 FOXQ1 forkhead box Q1 2 2
MIRT485618 FBXL5 F-box and leucine rich repeat protein 5 2 10
MIRT486751 CNOT4 CCR4-NOT transcription complex subunit 4 2 6
MIRT489599 ZDHHC20 zinc finger DHHC-type containing 20 2 10
MIRT489889 MPLKIP M-phase specific PLK1 interacting protein 2 2
MIRT491654 PDRG1 p53 and DNA damage regulated 1 2 10
MIRT492038 TSG101 tumor susceptibility 101 2 4
MIRT492361 SEMA7A semaphorin 7A (John Milton Hagen blood group) 2 2
MIRT492776 PDGFB platelet derived growth factor subunit B 2 2
MIRT493336 LAPTM4A lysosomal protein transmembrane 4 alpha 2 12
MIRT493611 HMGB3 high mobility group box 3 2 6
MIRT497468 DDR2 discoidin domain receptor tyrosine kinase 2 2 2
MIRT498059 SNX5 sorting nexin 5 2 6
MIRT499901 KIAA1191 KIAA1191 2 4
MIRT500489 ZBTB4 zinc finger and BTB domain containing 4 2 6
MIRT500685 TRIM37 tripartite motif containing 37 2 2
MIRT500760 TMEM127 transmembrane protein 127 2 6
MIRT501456 PTPN4 protein tyrosine phosphatase, non-receptor type 4 2 8
MIRT501559 POC1B-GALNT4 POC1B-GALNT4 readthrough 2 2
MIRT501983 MAPK1 mitogen-activated protein kinase 1 2 10
MIRT502000 MAP7 microtubule associated protein 7 2 8
MIRT502049 LAMTOR1 late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 2 6
MIRT502423 GALNT4 polypeptide N-acetylgalactosaminyltransferase 4 2 2
MIRT503044 CAMSAP2 calmodulin regulated spectrin associated protein family member 2 2 2
MIRT503821 TMEM242 transmembrane protein 242 2 4
MIRT504290 PARP1 poly(ADP-ribose) polymerase 1 2 6
MIRT504560 ZNF417 zinc finger protein 417 2 6
MIRT505054 ZNF202 zinc finger protein 202 2 6
MIRT505486 SRSF2 serine and arginine rich splicing factor 2 2 4
MIRT505836 POLR1B RNA polymerase I subunit B 2 4
MIRT506372 NUFIP2 NUFIP2, FMR1 interacting protein 2 2 4
MIRT506451 NACC2 NACC family member 2 2 4
MIRT506673 LZIC leucine zipper and CTNNBIP1 domain containing 2 4
MIRT506834 KIF23 kinesin family member 23 2 4
MIRT506880 KIAA0101 PCNA clamp associated factor 2 6
MIRT507359 FAM129A family with sequence similarity 129 member A 2 6
MIRT507957 BNIP2 BCL2 interacting protein 2 2 6
MIRT509433 MCM7 minichromosome maintenance complex component 7 2 6
MIRT510872 RAN RAN, member RAS oncogene family 2 8
MIRT511078 NIPA1 non imprinted in Prader-Willi/Angelman syndrome 1 2 4
MIRT511254 KLHL36 kelch like family member 36 2 6
MIRT513699 RBM20 RNA binding motif protein 20 2 4
MIRT513742 PKNOX1 PBX/knotted 1 homeobox 1 2 2
MIRT513981 CEP97 centrosomal protein 97 2 2
MIRT514092 EPS15L1 epidermal growth factor receptor pathway substrate 15 like 1 2 6
MIRT515928 MFAP2 microfibril associated protein 2 2 4
MIRT519574 ZNFX1 zinc finger NFX1-type containing 1 2 4
MIRT521297 RRAGD Ras related GTP binding D 2 4
MIRT521348 RPP14 ribonuclease P/MRP subunit p14 2 2
MIRT521693 PRKAA1 protein kinase AMP-activated catalytic subunit alpha 1 2 8
MIRT521778 PPIG peptidylprolyl isomerase G 2 8
MIRT522191 NR2C2 nuclear receptor subfamily 2 group C member 2 2 6
MIRT524696 BTG3 BTG anti-proliferation factor 3 2 8
MIRT525663 NHSL2 NHS like 2 2 2
MIRT527252 TMEM196 transmembrane protein 196 2 2
MIRT527466 CLEC12B C-type lectin domain family 12 member B 2 2
MIRT529535 ICMT isoprenylcysteine carboxyl methyltransferase 2 2
MIRT530146 HADHB hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit 2 2
MIRT530851 RAG1 recombination activating 1 2 4
MIRT531109 PEX13 peroxisomal biogenesis factor 13 2 2
MIRT534263 SLC12A7 solute carrier family 12 member 7 2 2
MIRT534756 RASGEF1A RasGEF domain family member 1A 2 2
MIRT535175 PLEKHB2 pleckstrin homology domain containing B2 2 2
MIRT535246 PIGA phosphatidylinositol glycan anchor biosynthesis class A 2 4
MIRT535401 PER1 period circadian clock 1 2 2
MIRT536036 MCUR1 mitochondrial calcium uniporter regulator 1 2 2
MIRT536347 LEFTY1 left-right determination factor 1 2 2
MIRT536413 KREMEN1 kringle containing transmembrane protein 1 2 2
MIRT536437 KMT2B lysine methyltransferase 2B 2 6
MIRT536604 IRF2 interferon regulatory factor 2 2 2
MIRT536642 INO80D INO80 complex subunit D 2 2
MIRT536860 HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 2 2
MIRT537241 GALNT3 polypeptide N-acetylgalactosaminyltransferase 3 2 2
MIRT537728 ELAVL2 ELAV like RNA binding protein 2 2 2
MIRT537988 DPP8 dipeptidyl peptidase 8 2 2
MIRT538037 DNAJB6 DnaJ heat shock protein family (Hsp40) member B6 2 2
MIRT538255 CUL3 cullin 3 2 4
MIRT538525 CLCN3 chloride voltage-gated channel 3 2 2
MIRT538659 CCSAP centriole, cilia and spindle associated protein 2 2
MIRT538779 C7orf60 base methyltransferase of 25S rRNA 2 homolog 2 4
MIRT538849 BTG1 BTG anti-proliferation factor 1 2 2
MIRT538923 BRI3BP BRI3 binding protein 2 6
MIRT539114 ARL10 ADP ribosylation factor like GTPase 10 2 2
MIRT539454 ADARB2 adenosine deaminase, RNA specific B2 (inactive) 2 2
MIRT541085 RLIM ring finger protein, LIM domain interacting 2 2
MIRT543117 SKA2 spindle and kinetochore associated complex subunit 2 2 2
MIRT543181 FICD FIC domain containing 2 2
MIRT543575 RPF2 ribosome production factor 2 homolog 2 4
MIRT544113 IPMK inositol polyphosphate multikinase 2 2
MIRT544625 CSDE1 cold shock domain containing E1 2 2
MIRT544699 ZNF224 zinc finger protein 224 2 4
MIRT544992 MFF mitochondrial fission factor 2 4
MIRT546248 TNFRSF21 TNF receptor superfamily member 21 2 2
MIRT546282 TMEM30A transmembrane protein 30A 2 4
MIRT546290 TMEM200C transmembrane protein 200C 2 4
MIRT546558 SATB2 SATB homeobox 2 2 2
MIRT546815 RAP2C RAP2C, member of RAS oncogene family 2 2
MIRT547046 POGZ pogo transposable element derived with ZNF domain 2 2
MIRT547474 MBNL3 muscleblind like splicing regulator 3 2 4
MIRT547761 KATNAL1 katanin catalytic subunit A1 like 1 2 2
MIRT547892 HSPA13 heat shock protein family A (Hsp70) member 13 2 2
MIRT548315 EPHA4 EPH receptor A4 2 2
MIRT548383 ENPP5 ectonucleotide pyrophosphatase/phosphodiesterase 5 (putative) 2 4
MIRT548460 EGLN3 egl-9 family hypoxia inducible factor 3 2 2
MIRT548579 DNAJB14 DnaJ heat shock protein family (Hsp40) member B14 2 2
MIRT548858 CERCAM cerebral endothelial cell adhesion molecule 2 2
MIRT548896 CHEK2 checkpoint kinase 2 2 4
MIRT549319 ARHGAP12 Rho GTPase activating protein 12 2 4
MIRT550302 ZNF681 zinc finger protein 681 2 2
MIRT551120 ZNF107 zinc finger protein 107 2 2
MIRT551406 DCTPP1 dCTP pyrophosphatase 1 2 2
MIRT552173 DAD1 defender against cell death 1 2 2
MIRT552856 WIPF2 WAS/WASL interacting protein family member 2 2 2
MIRT552892 WASL Wiskott-Aldrich syndrome like 2 4
MIRT553075 UEVLD UEV and lactate/malate dehyrogenase domains 2 2
MIRT553668 TFAP4 transcription factor AP-4 2 4
MIRT553700 TCF7L2 transcription factor 7 like 2 2 2
MIRT554608 RPS6KA5 ribosomal protein S6 kinase A5 2 2
MIRT554860 RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis) 2 2
MIRT556157 MECP2 methyl-CpG binding protein 2 2 2
MIRT556179 MCC mutated in colorectal cancers 2 2
MIRT556529 LIN52 lin-52 DREAM MuvB core complex component 2 2
MIRT556723 KLHL21 kelch like family member 21 2 4
MIRT557054 HOXB3 homeobox B3 2 2
MIRT557587 GNPTAB N-acetylglucosamine-1-phosphate transferase alpha and beta subunits 2 2
MIRT557661 GATA6 GATA binding protein 6 2 2
MIRT557753 FRS2 fibroblast growth factor receptor substrate 2 2 2
MIRT557881 FEM1B fem-1 homolog B 2 4
MIRT558215 EFCAB14 EF-hand calcium binding domain 14 2 4
MIRT558264 DYNC1LI2 dynein cytoplasmic 1 light intermediate chain 2 2 2
MIRT558327 DNAJC28 DnaJ heat shock protein family (Hsp40) member C28 2 4
MIRT558766 CFL2 cofilin 2 2 2
MIRT561037 ASB6 ankyrin repeat and SOCS box containing 6 2 2
MIRT561324 ZBTB37 zinc finger and BTB domain containing 37 2 2
MIRT561641 RUNX3 runt related transcription factor 3 2 2
MIRT562555 CCDC71L coiled-coil domain containing 71 like 2 4
MIRT562961 LRPAP1 LDL receptor related protein associated protein 1 2 2
MIRT564680 ZNF35 zinc finger protein 35 2 2
MIRT565694 SESN3 sestrin 3 2 2
MIRT565910 SCAMP2 secretory carrier membrane protein 2 2 2
MIRT566141 RACGAP1 Rac GTPase activating protein 1 2 2
MIRT567047 KCNB1 potassium voltage-gated channel subfamily B member 1 2 2
MIRT567076 KBTBD2 kelch repeat and BTB domain containing 2 2 2
MIRT567539 FGFR1OP FGFR1 oncogene partner 2 2
MIRT567624 FAM210A family with sequence similarity 210 member A 2 2
MIRT570321 ZNF70 zinc finger protein 70 2 2
MIRT571759 PSD3 pleckstrin and Sec7 domain containing 3 2 2
MIRT571857 NKIRAS1 NFKB inhibitor interacting Ras like 1 2 2
MIRT573372 LIMA1 LIM domain and actin binding 1 2 2
MIRT574561 NR2F2 nuclear receptor subfamily 2 group F member 2 2 2
MIRT614729 ATAT1 alpha tubulin acetyltransferase 1 2 4
MIRT617877 ESR1 estrogen receptor 1 2 2
MIRT624421 CBX8 chromobox 8 2 2
MIRT625865 SLC35C2 solute carrier family 35 member C2 2 2
MIRT630703 DICER1 dicer 1, ribonuclease III 2 4
MIRT632514 PTPN9 protein tyrosine phosphatase, non-receptor type 9 2 2
MIRT641797 USP32 ubiquitin specific peptidase 32 2 2
MIRT663625 SEC23B Sec23 homolog B, coat complex II component 2 2
MIRT680135 ADRBK2 G protein-coupled receptor kinase 3 2 2
MIRT702388 KLF10 Kruppel like factor 10 2 2
MIRT707830 TMEM133 transmembrane protein 133 2 2
MIRT708885 MOCS2 molybdenum cofactor synthesis 2 2 2
MIRT709122 C3orf18 chromosome 3 open reading frame 18 2 2
MIRT709635 KBTBD6 kelch repeat and BTB domain containing 6 2 2
MIRT710596 CDCA4 cell division cycle associated 4 2 2
MIRT710802 IFNLR1 interferon lambda receptor 1 2 2
MIRT711782 RFXAP regulatory factor X associated protein 2 2
MIRT713344 KLRD1 killer cell lectin like receptor D1 2 2
MIRT713640 MED8 mediator complex subunit 8 2 2
MIRT713916 IGF2R insulin like growth factor 2 receptor 2 2
MIRT715068 TMTC1 transmembrane and tetratricopeptide repeat containing 1 2 2
MIRT715206 FKTN fukutin 2 2
MIRT717819 FAM114A1 family with sequence similarity 114 member A1 2 2
MIRT720543 CHERP calcium homeostasis endoplasmic reticulum protein 2 2
MIRT720636 ELF5 E74 like ETS transcription factor 5 2 2
MIRT721703 ISY1 ISY1 splicing factor homolog 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-519c Bilobalide NULL 73581 Quantitative real-time PCR Human breast cancer MCF-7 cells 21796641 2011 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-519c Docetaxel+Cisplatin+5-Fluorouracil resistant tissue (hypopharyngeal squamous cell carcinoma)
hsa-miR-519c-3p Mitoxantrone 4212 NSC279836 approved sensitive Low Breast Cancer cell line (MCF-7)
hsa-miR-519c-3p Cisplatin 5460033 NSC119875 approved resistant High Germ Cell Tumor cell line (NTERA-2)
hsa-miR-519c-3p Vinorelbine 44424639 approved resistant High Non-Small Cell Lung Cancer cell line (H358, H1993)
hsa-miR-519c-3p Tamoxifen 2733525 NSC180973 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-519c-3p Gemcitabine 60750 NSC613327 approved sensitive Low Pancreatic Cancer cell line (MIA-PaCa-2)
hsa-miR-519c-3p Osimertinib 71496458 NSC779217 approved resistant cell line (PC9)
hsa-miR-519c-3p Vemurafenib 42611257 NSC761431 approved resistant cell line (451Lu)
hsa-miR-519c-3p Vemurafenib 42611257 NSC761431 approved resistant cell line (LM36)
hsa-miR-519c-3p Fluorouracil 3385 NSC19893 approved resistant cell line (KM12C) (72 h)
hsa-miR-519c-3p Sunitinib 5329102 NSC750690 approved resistant tissue (CardA)
hsa-miR-519c-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)

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