miRTarBase - #MIRT061339


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pre-miRNA Information
pre-miRNA hsa-mir-605   
Genomic Coordinates chr10: 51299573 - 51299655
Synonyms MIRN605, hsa-mir-605, MIR605
Description Homo sapiens miR-605 stem-loop
Comment None
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-605-3p
Sequence 51| AGAAGGCACUAUGAGAUUUAGA |72
Evidence Experimental
Experiments Illumina
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 4 10 + 51299626 27587585, 28550310, 26028588, 26449202, 26487287, 29165639 MiREDiBase
A-to-I 14 10 + 51299636 29233923 MiREDiBase
A-to-I 20 10 + 51299642 18684997, 26449202, 27587585, 29233923 MiREDiBase
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs759219082 5 dbSNP
rs1491224174 9 dbSNP
rs746611214 10 dbSNP
rs367648737 11 dbSNP
rs1359467239 14 dbSNP
rs1442565019 16 dbSNP
Putative Targets

Gene Information
Gene Symbol WEE1   
Synonyms WEE1A, WEE1hu
Description WEE1 G2 checkpoint kinase
Transcript NM_001143976   
Other Transcripts NM_003390   
Expression
Putative miRNA Targets on WEE1
3'UTR of WEE1
(miRNA target sites are highlighted)		 
>WEE1|NM_001143976|3'UTR
   1 GCTACTCCTTTCCCACCTCCCCCTGAACACTGTGACAAGAGGAAGCTAGGTTGAAATCACTGATAGAATCCAGTTTGCAA
  81 TTACTTTCTCGATTGGTGTCAGTAGTTTTACTGATTAGGACTTTTATTGTGAATTACAGTTGAAAGCTGTATTTTGATGA
 161 TTGCTATGTCAGGCTTTCATCTAATCTTACCAGTCTGTCTTCTGTAGGATGTGTCACTGTTGGATGTTACACCAGCCTTT
 241 CCAGGGTTAACCACTGTGGTGGTGTGCTGCTTATAGTTTGCTGTTGCATTGTAATAAAAGGTGTCTTTCCCTGTAGTGAC
 321 CTGTAAAAAGTACTCAAGGGCTTTATTACAGACATACCCTCCCTTTGAAAAGGGACATGCTAAAAGACTCATTACTACTC
 401 AGCCTTCAATGTACCTGTGTGTCCATCTTATATTTCTTTTTTTTTTAATTGTGAATTAGACTTGTATATCCCACTGGGAG
 481 CACTTTGTAGGCATTGCATGAACCATGGGATGATGATTCTGTGGAGGTATTGCCTTGTGAATTTGCTGCTATTTTAGTTT
 561 TGTCTTTGCTGTAAACTTGTAGCATTAAACAATCATTGTTGTTAATAGGTCTTCTTTTTGAAACAATTATGTGAAATGTA
 641 TAGCTGCTTTTGATGAAAAGCAGCTATTTGCCTTTTTTTTTTTTTCCTTTGAACTTTGAAGCTAGTGCATTGGAAAAATG
 721 CACCCTTTCCCTCCTTTGGAATGCTGTATTAATGTAGTATAATAATTACTGGTTTTGTAACTTGTTCTGGTAATGTCCTT
 801 CCCGGACTCTTTTTAAATGTCTCCCCCTAAGTTTTATACTTGATTGTATTATTAGTCTGTTTTTAAATGTTTTGCCCGGT
 881 TTTTCTCTTCAATATTTGTGTATATAAACCGATCTTCGTGATACTGTACATAGCTGTTTGAAATGCCAGAATGACTTCTG
 961 ACATTCCAAGTTTTTCACAAAATATATTTTATCTGTGATTAGCCATTTGACTAATAATACTGGCTAACAGATGTTGAAAA
1041 AAATTGTCTGTTTGTTTTCTCATTAATTTTGGTCTAAAACATGTTTGCACTTGTCTTTGACTTGTGTTTTATTAACATTG
1121 ATTGGCATATTAAAAGTCACTCTGAGCTTACCTTAATTGTCTAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' agauUUAGAGU-AUC--ACGGAAGa 5'
              |||||:|  ||  ||:|||| 
Target 5' atctAATCTTACCAGTCTGTCTTCt 3'
 179 - 203 144.00 -14.40
2 
miRNA  3' agaUUUAGAGUAUC-ACGGAAGa 5'
             |||| | |||| |||:||: 
Target 5' gtgAAATGT-ATAGCTGCTTTTg 3'
 631 - 652 134.00 -8.70
3 
miRNA  3' agAUUUAGA-----GUAUCACGGAAga 5'
            |:| |||      :|| ||||||  
Target 5' gaTGATTCTGTGGAGGTATTGCCTTgt 3'
 512 - 538 132.00 -8.00
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30449243 9 COSMIC
COSN30162114 13 COSMIC
COSN30663006 16 COSMIC
COSN30100582 69 COSMIC
COSN30529547 86 COSMIC
COSN30155750 89 COSMIC
COSN31525104 125 COSMIC
COSN31594923 127 COSMIC
COSN31522421 237 COSMIC
COSN31590162 272 COSMIC
COSN23066642 326 COSMIC
COSN23076339 327 COSMIC
COSN26112696 346 COSMIC
COSN7293499 437 COSMIC
COSN20107961 447 COSMIC
COSN27512625 447 COSMIC
COSN26559221 460 COSMIC
COSN31535728 533 COSMIC
COSN25300466 596 COSMIC
COSN8286498 598 COSMIC
COSN31590169 600 COSMIC
COSN18723337 686 COSMIC
COSN20107963 686 COSMIC
COSN27552291 686 COSMIC
COSN7293503 810 COSMIC
COSN15738080 992 COSMIC
COSN31541840 1045 COSMIC
COSN20107965 1055 COSMIC
COSN26577629 1102 COSMIC
COSN29467337 1120 COSMIC
COSN26552244 1140 COSMIC
COSN29144415 1191 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1253049033 2 dbSNP
rs1380942069 3 dbSNP
rs376918551 6 dbSNP
rs746339662 12 dbSNP
rs1040315042 13 dbSNP
rs1161917803 15 dbSNP
rs772545414 20 dbSNP
rs559821398 21 dbSNP
rs761462789 23 dbSNP
rs764815770 30 dbSNP
rs1310890858 31 dbSNP
rs770854702 31 dbSNP
rs766054394 37 dbSNP
rs776776793 37 dbSNP
rs772733810 41 dbSNP
rs898648767 49 dbSNP
rs762412100 52 dbSNP
rs1311350444 56 dbSNP
rs1411583595 60 dbSNP
rs931524860 62 dbSNP
rs929380682 72 dbSNP
rs1306817151 80 dbSNP
rs865955619 85 dbSNP
rs754888514 89 dbSNP
rs553359817 91 dbSNP
rs542331153 92 dbSNP
rs1281935535 99 dbSNP
rs1422934845 102 dbSNP
rs149282089 112 dbSNP
rs1184788330 113 dbSNP
rs906074281 115 dbSNP
rs1251759479 117 dbSNP
rs759100193 123 dbSNP
rs1489489945 125 dbSNP
rs1041084884 141 dbSNP
rs901730965 157 dbSNP
rs1330157026 167 dbSNP
rs996482827 168 dbSNP
rs1028933938 173 dbSNP
rs1034662993 179 dbSNP
rs1271906257 191 dbSNP
rs1306162860 193 dbSNP
rs960755532 201 dbSNP
rs1437593786 205 dbSNP
rs779089246 210 dbSNP
rs1291348453 214 dbSNP
rs542356383 222 dbSNP
rs1457034393 224 dbSNP
rs1388933192 230 dbSNP
rs1021236337 247 dbSNP
rs968284969 247 dbSNP
rs1411744077 253 dbSNP
rs531145889 255 dbSNP
rs1265354008 259 dbSNP
rs979358665 263 dbSNP
rs1000740651 264 dbSNP
rs1030675853 275 dbSNP
rs1270284796 334 dbSNP
rs1207102145 338 dbSNP
rs753258844 346 dbSNP
rs1240571270 352 dbSNP
rs1233870505 354 dbSNP
rs1440852254 354 dbSNP
rs1183003739 355 dbSNP
rs956458923 357 dbSNP
rs991763972 378 dbSNP
rs964567579 383 dbSNP
rs1439548480 385 dbSNP
rs1365425559 389 dbSNP
rs1366820884 401 dbSNP
rs758840115 403 dbSNP
rs143502910 404 dbSNP
rs1455364417 405 dbSNP
rs751898917 410 dbSNP
rs757591885 411 dbSNP
rs1419146116 414 dbSNP
rs1047797599 425 dbSNP
rs1198193288 431 dbSNP
rs1188644183 437 dbSNP
rs139009920 437 dbSNP
rs920221141 446 dbSNP
rs141541085 447 dbSNP
rs931436959 447 dbSNP
rs570805549 448 dbSNP
rs1400866018 449 dbSNP
rs1451847250 452 dbSNP
rs533485978 455 dbSNP
rs1341713399 460 dbSNP
rs1244951095 461 dbSNP
rs1432440679 471 dbSNP
rs1325495211 481 dbSNP
rs1335206258 492 dbSNP
rs1398180676 493 dbSNP
rs908602869 495 dbSNP
rs1173536476 498 dbSNP
rs1431011195 500 dbSNP
rs1392097202 520 dbSNP
rs1166797007 531 dbSNP
rs1449026053 539 dbSNP
rs1369289148 541 dbSNP
rs1315753750 548 dbSNP
rs1217115408 553 dbSNP
rs1253879366 558 dbSNP
rs1210058928 572 dbSNP
rs944116406 573 dbSNP
rs1041177929 574 dbSNP
rs1260415043 581 dbSNP
rs546172356 583 dbSNP
rs1225568381 588 dbSNP
rs1338290968 592 dbSNP
rs749523604 595 dbSNP
rs1200419331 596 dbSNP
rs1246593685 596 dbSNP
rs1312720300 602 dbSNP
rs1372960258 604 dbSNP
rs1410904198 604 dbSNP
rs1306205254 607 dbSNP
rs1254747157 608 dbSNP
rs768795097 610 dbSNP
rs867490165 612 dbSNP
rs896142190 624 dbSNP
rs1009767335 627 dbSNP
rs899815933 632 dbSNP
rs1186969780 638 dbSNP
rs1020701580 639 dbSNP
rs1253919935 639 dbSNP
rs147995463 641 dbSNP
rs1202364081 642 dbSNP
rs1436698356 642 dbSNP
rs967734211 646 dbSNP
rs1211257380 653 dbSNP
rs535171306 654 dbSNP
rs1293002282 656 dbSNP
rs1049403 657 dbSNP
rs1352824135 667 dbSNP
rs1286965580 673 dbSNP
rs1350530175 673 dbSNP
rs368710857 673 dbSNP
rs397848312 673 dbSNP
rs77937016 673 dbSNP
rs1394049112 686 dbSNP
rs200750136 686 dbSNP
rs1424105786 687 dbSNP
rs903777130 689 dbSNP
rs1469134834 691 dbSNP
rs1170722079 692 dbSNP
rs1404345051 693 dbSNP
rs1001069917 697 dbSNP
rs1030811630 698 dbSNP
rs976011048 706 dbSNP
rs956430056 712 dbSNP
rs1317029052 714 dbSNP
rs1337888682 715 dbSNP
rs923297651 721 dbSNP
rs1246711896 723 dbSNP
rs771214888 726 dbSNP
rs1013277494 735 dbSNP
rs867315135 740 dbSNP
rs983817548 757 dbSNP
rs1272186046 760 dbSNP
rs1209008177 780 dbSNP
rs1024705740 785 dbSNP
rs1280446022 791 dbSNP
rs1319008930 792 dbSNP
rs1233055700 800 dbSNP
rs79294375 804 dbSNP
rs1347757164 817 dbSNP
rs1434434236 823 dbSNP
rs980469369 823 dbSNP
rs942064386 827 dbSNP
rs1321430822 839 dbSNP
rs1201048731 843 dbSNP
rs1262593822 846 dbSNP
rs920129956 852 dbSNP
rs10534 860 dbSNP
rs776667386 868 dbSNP
rs927426932 877 dbSNP
rs1156669099 878 dbSNP
rs982918420 879 dbSNP
rs1264237221 884 dbSNP
rs538045939 893 dbSNP
rs938961494 903 dbSNP
rs746006691 906 dbSNP
rs1196566554 908 dbSNP
rs944211107 910 dbSNP
rs1451997629 911 dbSNP
rs780269087 918 dbSNP
rs921383125 919 dbSNP
rs932611059 920 dbSNP
rs896181867 922 dbSNP
rs1379232852 923 dbSNP
rs1043065542 925 dbSNP
rs147130750 956 dbSNP
rs1313253127 963 dbSNP
rs577989100 970 dbSNP
rs903627619 985 dbSNP
rs191119627 991 dbSNP
rs1000550485 998 dbSNP
rs1052332245 1006 dbSNP
rs892284571 1014 dbSNP
rs1286847285 1015 dbSNP
rs1359566619 1029 dbSNP
rs1336064842 1032 dbSNP
rs1432847642 1040 dbSNP
rs1393954276 1044 dbSNP
rs1358110154 1045 dbSNP
rs1168681881 1047 dbSNP
rs202068253 1049 dbSNP
rs79680752 1049 dbSNP
rs200938961 1053 dbSNP
rs1013414066 1055 dbSNP
rs1024644076 1063 dbSNP
rs1186256536 1067 dbSNP
rs1483767066 1068 dbSNP
rs904940921 1073 dbSNP
rs553377220 1082 dbSNP
rs1485631781 1090 dbSNP
rs1002253117 1091 dbSNP
rs997880967 1096 dbSNP
rs78738598 1101 dbSNP
rs73408237 1102 dbSNP
rs1344548047 1103 dbSNP
rs1026662912 1111 dbSNP
rs952512028 1113 dbSNP
rs983013060 1114 dbSNP
rs1229150018 1117 dbSNP
rs1379605942 1117 dbSNP
rs1285806253 1128 dbSNP
rs1015892380 1131 dbSNP
rs1412788422 1153 dbSNP
rs1374785865 1155 dbSNP
rs965528254 1162 dbSNP
rs976927208 1164 dbSNP
rs1169287858 1173 dbSNP
rs983484267 1174 dbSNP
rs1416321048 1189 dbSNP
rs771911373 1191 dbSNP
rs921309979 1195 dbSNP
rs1234640471 1196 dbSNP
rs932771980 1198 dbSNP
rs1285974786 1200 dbSNP
rs1186270285 1205 dbSNP
rs1016249342 1208 dbSNP
rs1253203532 1216 dbSNP
rs1207970219 1218 dbSNP
rs1479685613 1221 dbSNP
rs979143472 1225 dbSNP
rs1222577891 1227 dbSNP
rs763434021 1228 dbSNP
rs1294837869 1238 dbSNP
rs1231252893 1245 dbSNP
rs773165281 1248 dbSNP
rs1354697865 1251 dbSNP
rs925965720 1256 dbSNP
rs1218967607 1259 dbSNP
rs760413867 1262 dbSNP
rs927480628 1264 dbSNP
rs938861310 1272 dbSNP
rs1488282858 1278 dbSNP
rs1351275125 1283 dbSNP
rs1189188857 1284 dbSNP
rs1461222593 1291 dbSNP
rs544466948 1298 dbSNP
rs892419869 1299 dbSNP
rs1417922684 1300 dbSNP
rs949180665 1302 dbSNP
rs1433663477 1315 dbSNP
rs550636699 1318 dbSNP
rs1191862063 1321 dbSNP
rs1042058355 1329 dbSNP
rs1378459769 1333 dbSNP
rs776329008 1333 dbSNP
rs573205730 1337 dbSNP
rs1271541538 1343 dbSNP
rs1440994489 1344 dbSNP
rs936457094 1348 dbSNP
rs1038755745 1350 dbSNP
rs1268594118 1364 dbSNP
rs567054958 1368 dbSNP
rs1315067738 1369 dbSNP
rs904910909 1370 dbSNP
rs1386871042 1371 dbSNP
rs1001946623 1375 dbSNP
rs1027172567 1379 dbSNP
rs1323450019 1382 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM545212. RNA binding protein: AGO1. Condition:Control PAR-CLIP data was present in GSM545214. RNA binding protein: AGO3. Condition:Control PAR-CLIP data was present in GSM545216. RNA binding protein: AGO2. Condition:miR-124 transfection ...

- Hafner M; Landthaler M; Burger L; Khorshid et al., 2010, Cell.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' agaUUUAGAGU----AUCA--CGGAAGa 5'
             ||: ||||    || |  |||||| 
Target 5' uaaAAGACUCAUUACUACUCAGCCUUCa 3'
 		2 - 29
Article - Hafner M; Landthaler M; Burger L; Khorshid et al.
- Cell, 2010
RNA transcripts are subject to posttranscriptional gene regulation involving hundreds of RNA-binding proteins (RBPs) and microRNA-containing ribonucleoprotein complexes (miRNPs) expressed in a cell-type dependent fashion. We developed a cell-based crosslinking approach to determine at high resolution and transcriptome-wide the binding sites of cellular RBPs and miRNPs. The crosslinked sites are revealed by thymidine to cytidine transitions in the cDNAs prepared from immunopurified RNPs of 4-thiouridine-treated cells. We determined the binding sites and regulatory consequences for several intensely studied RBPs and miRNPs, including PUM2, QKI, IGF2BP1-3, AGO/EIF2C1-4 and TNRC6A-C. Our study revealed that these factors bind thousands of sites containing defined sequence motifs and have distinct preferences for exonic versus intronic or coding versus untranslated transcript regions. The precise mapping of binding sites across the transcriptome will be critical to the interpretation of the rapidly emerging data on genetic variation between individuals and how these variations contribute to complex genetic diseases.
LinkOut: [PMID: 20371350]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Disease 7465.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM1065667. RNA binding protein: AGO1. Condition:4-thiouridine "PAR-CLIP data was present in GSM1065669. RNA binding protein: AGO1. Condition:4-thiouridine ...

- Memczak S; Jens M; Elefsinioti A; Torti F; et al., 2013, Nature.

Article - Memczak S; Jens M; Elefsinioti A; Torti F; et al.
- Nature, 2013
Circular RNAs (circRNAs) in animals are an enigmatic class of RNA with unknown function. To explore circRNAs systematically, we sequenced and computationally analysed human, mouse and nematode RNA. We detected thousands of well-expressed, stable circRNAs, often showing tissue/developmental-stage-specific expression. Sequence analysis indicated important regulatory functions for circRNAs. We found that a human circRNA, antisense to the cerebellar degeneration-related protein 1 transcript (CDR1as), is densely bound by microRNA (miRNA) effector complexes and harbours 63 conserved binding sites for the ancient miRNA miR-7. Further analyses indicated that CDR1as functions to bind miR-7 in neuronal tissues. Human CDR1as expression in zebrafish impaired midbrain development, similar to knocking down miR-7, suggesting that CDR1as is a miRNA antagonist with a miRNA-binding capacity ten times higher than any other known transcript. Together, our data provide evidence that circRNAs form a large class of post-transcriptional regulators. Numerous circRNAs form by head-to-tail splicing of exons, suggesting previously unrecognized regulatory potential of coding sequences.
LinkOut: [PMID: 23446348]
CLIP-seq Support 1 for dataset GSM545212
Method / RBP PAR-CLIP / AGO1
Cell line / Condition HEK293 / Control
Location of target site ENST00000299613.6 | 3UTR | CUCAUUACUACUCAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 20371350 / GSE21578
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM545214
Method / RBP PAR-CLIP / AGO3
Cell line / Condition HEK293 / Control
Location of target site ENST00000299613.6 | 3UTR | ACUCAUUACUACUCAGCCUUCAAU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 20371350 / GSE21578
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM545216
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / miR-124 transfection
Location of target site ENST00000299613.6 | 3UTR | CUAAAAGACUCAUUACUACUCAGCCUUCAAUGUACCUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 20371350 / GSE21578
CLIP-seq Viewer Link
CLIP-seq Support 4 for dataset GSM1065667
Method / RBP PAR-CLIP / AGO1
Cell line / Condition HEK293 / 4-thiouridine, ML_MM_6
Location of target site ENST00000299613.6 | 3UTR | CUAAAAGACUCAUUACUACUCAGCCUUCAAUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23446348 / GSE43573
CLIP-seq Viewer Link
CLIP-seq Support 5 for dataset GSM1065669
Method / RBP PAR-CLIP / AGO1
Cell line / Condition HEK293 / 4-thiouridine, ML_MM_8
Location of target site ENST00000299613.6 | 3UTR | AAGACUCAUUACUACUCAGCCUUCAAUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23446348 / GSE43573
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
100 hsa-miR-605-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT061339 WEE1 WEE1 G2 checkpoint kinase 2 4
MIRT061584 BTG2 BTG anti-proliferation factor 2 2 6
MIRT076140 WDR81 WD repeat domain 81 2 2
MIRT079361 CCDC137 coiled-coil domain containing 137 2 2
MIRT079547 VAMP3 vesicle associated membrane protein 3 2 2
MIRT096242 CANX calnexin 2 2
MIRT243877 G3BP1 G3BP stress granule assembly factor 1 2 4
MIRT249186 AKIRIN1 akirin 1 2 8
MIRT273604 SP1 Sp1 transcription factor 2 2
MIRT316766 FOXC1 forkhead box C1 2 4
MIRT322410 PPP2R2A protein phosphatase 2 regulatory subunit Balpha 2 2
MIRT370117 TRIB3 tribbles pseudokinase 3 2 2
MIRT392725 UBN2 ubinuclein 2 2 2
MIRT406910 PTBP1 polypyrimidine tract binding protein 1 2 2
MIRT407440 CTDSP1 CTD small phosphatase 1 2 2
MIRT441887 RD3 retinal degeneration 3 2 4
MIRT444979 C15orf52 chromosome 15 open reading frame 52 2 2
MIRT445241 FOXD4 forkhead box D4 2 2
MIRT445500 FOXD4L5 forkhead box D4 like 5 2 2
MIRT445503 FOXD4L4 forkhead box D4 like 4 2 2
MIRT447025 FOXD4L1 forkhead box D4 like 1 2 2
MIRT447743 TMCC3 transmembrane and coiled-coil domain family 3 2 2
MIRT448761 HDX highly divergent homeobox 2 2
MIRT450003 HAX1 HCLS1 associated protein X-1 2 2
MIRT452830 FAM131B family with sequence similarity 131 member B 2 2
MIRT452872 LAX1 lymphocyte transmembrane adaptor 1 2 2
MIRT453506 ARRB1 arrestin beta 1 2 2
MIRT454169 HIST1H2BK histone cluster 1 H2B family member k 2 2
MIRT458742 CES2 carboxylesterase 2 2 2
MIRT459166 HSPA6 heat shock protein family A (Hsp70) member 6 2 21
MIRT460246 IL17RB interleukin 17 receptor B 2 4
MIRT460514 SDE2 SDE2 telomere maintenance homolog 2 2
MIRT460698 RNF157 ring finger protein 157 2 2
MIRT461481 METTL1 methyltransferase like 1 2 2
MIRT462617 C20orf27 chromosome 20 open reading frame 27 2 4
MIRT463233 ZNF131 zinc finger protein 131 2 2
MIRT465699 TNPO2 transportin 2 2 8
MIRT466304 TIMM22 translocase of inner mitochondrial membrane 22 2 2
MIRT468957 RPS14 ribosomal protein S14 2 6
MIRT469571 RARA retinoic acid receptor alpha 2 2
MIRT469685 RAB5B RAB5B, member RAS oncogene family 2 2
MIRT470800 PMP22 peripheral myelin protein 22 2 2
MIRT471649 PANK2 pantothenate kinase 2 2 4
MIRT471722 OTUB1 OTU deubiquitinase, ubiquitin aldehyde binding 1 2 2
MIRT472281 NFIB nuclear factor I B 2 4
MIRT473680 MAPKBP1 mitogen-activated protein kinase binding protein 1 2 2
MIRT475859 H6PD hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase 2 2
MIRT477326 EPHA2 EPH receptor A2 2 2
MIRT477831 DYRK3 dual specificity tyrosine phosphorylation regulated kinase 3 2 2
MIRT478572 CTNND1 catenin delta 1 2 4
MIRT479634 CD81 CD81 molecule 2 2
MIRT481950 ANKRD11 ankyrin repeat domain 11 2 2
MIRT483696 ZNF74 zinc finger protein 74 2 6
MIRT488798 MALT1 MALT1 paracaspase 2 2
MIRT489066 STARD3 StAR related lipid transfer domain containing 3 2 2
MIRT492533 PSMD11 proteasome 26S subunit, non-ATPase 11 2 2
MIRT492857 NRARP NOTCH regulated ankyrin repeat protein 2 2
MIRT496793 BTRC beta-transducin repeat containing E3 ubiquitin protein ligase 2 2
MIRT500122 ZNF106 zinc finger protein 106 2 4
MIRT505359 TMEM167A transmembrane protein 167A 2 2
MIRT506786 KLHL15 kelch like family member 15 2 6
MIRT510692 SRM spermidine synthase 2 6
MIRT515841 CEP104 centrosomal protein 104 2 4
MIRT516448 ADAMTS4 ADAM metallopeptidase with thrombospondin type 1 motif 4 2 4
MIRT528855 PKP1 plakophilin 1 2 2
MIRT533848 TET3 tet methylcytosine dioxygenase 3 2 2
MIRT539025 ATXN7L1 ataxin 7 like 1 2 4
MIRT542872 NR6A1 nuclear receptor subfamily 6 group A member 1 2 2
MIRT546543 SATB2 SATB homeobox 2 2 2
MIRT554114 SMARCE1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1 2 2
MIRT560569 ZNF460 zinc finger protein 460 2 2
MIRT560796 EPM2AIP1 EPM2A interacting protein 1 2 2
MIRT562836 GCFC2 GC-rich sequence DNA-binding factor 2 2 2
MIRT563109 IFRD2 interferon related developmental regulator 2 2 2
MIRT564177 MRPL49 mitochondrial ribosomal protein L49 2 2
MIRT564283 ASB1 ankyrin repeat and SOCS box containing 1 2 2
MIRT564350 USP22 ubiquitin specific peptidase 22 2 2
MIRT565279 TNFRSF21 TNF receptor superfamily member 21 2 2
MIRT565338 TMEM104 transmembrane protein 104 2 2
MIRT565905 SCAMP2 secretory carrier membrane protein 2 2 2
MIRT567108 ITGB1 integrin subunit beta 1 2 2
MIRT567601 FANCF Fanconi anemia complementation group F 2 2
MIRT567779 DGAT2 diacylglycerol O-acyltransferase 2 2 2
MIRT568075 CENPQ centromere protein Q 2 2
MIRT624304 COL12A1 collagen type XII alpha 1 chain 2 2
MIRT644395 CDKL1 cyclin dependent kinase like 1 2 2
MIRT661547 ZNF674 zinc finger protein 674 2 4
MIRT670949 IRAK3 interleukin 1 receptor associated kinase 3 2 2
MIRT672951 AKAP5 A-kinase anchoring protein 5 2 2
MIRT697426 ZFP36 ZFP36 ring finger protein 2 2
MIRT700793 PIAS2 protein inhibitor of activated STAT 2 2 2
MIRT702657 ITGA3 integrin subunit alpha 3 2 2
MIRT708945 FZR1 fizzy and cell division cycle 20 related 1 2 2
MIRT713657 PLCE1 phospholipase C epsilon 1 2 2
MIRT719239 CYSLTR2 cysteinyl leukotriene receptor 2 2 2
MIRT719951 BLOC1S6 biogenesis of lysosomal organelles complex 1 subunit 6 2 2
MIRT722048 HLA-E major histocompatibility complex, class I, E 2 2
MIRT722201 URM1 ubiquitin related modifier 1 2 2
MIRT724790 C1D C1D nuclear receptor corepressor 2 2
MIRT734347 CYP2B6 cytochrome P450 family 2 subfamily B member 6 3 0
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-605 Anthranilamide-pyrazolo[1,5-a]pyrimidine NULL NULL Quantitative real-time PCR neuroblastoma cells 23992861 2013 up-regualted
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-605 Ceritinib 57379345 NSC776422 approved resistant High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-mir-605 Paclitaxel 36314 NSC125973 approved sensitive cell line (A2780)
hsa-mir-605 Cisplatin 5460033 NSC119875 approved sensitive cell line (A2780)
hsa-mir-605 Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)
hsa-miR-605-3p Ceritinib 57379345 NSC776422 approved resistant High Non-Small Cell Lung Cancer cell line (H3122, H2228)

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