miRTarBase - #MIRT061351


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pre-miRNA Information
pre-miRNA hsa-let-7a-1   
Genomic Coordinates chr9: 94175957 - 94176036
Synonyms LET7A1, MIRNLET7A1, let-7a-1, MIRLET7A1
Description Homo sapiens let-7a-1 stem-loop
Comment let-7a-3p cloned in has a 1 nt 3' extension (U), which is incompatible with the genome sequence.
RNA Secondary Structure
Associated Diseases
pre-miRNA hsa-let-7a-3   
Genomic Coordinates chr22: 46112749 - 46112822
Synonyms LET7A3, MIRNLET7A3, let-7a-3, MIRLET7A3
Description Homo sapiens let-7a-3 stem-loop
Comment let-7a-3p cloned in has a 1 nt 3' extension (U), which is incompatible with the genome sequence.
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-let-7a-3p
Sequence 57| CUAUACAAUCUACUGUCUUUC |77
Evidence Experimental
Experiments Cloned
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 5 9 + 94176017 29233923 MiREDiBase
A-to-I 5 22 + 46112804 29233923 MiREDiBase
A-to-I 12 22 + 46112811 29233923 MiREDiBase
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs972845958 1 dbSNP
rs781681931 2 dbSNP
rs748585376 3 dbSNP
rs779353569 6 dbSNP
rs1198423693 8 dbSNP
rs970921980 8 dbSNP
rs372596018 9 dbSNP
rs770208205 10 dbSNP
rs1453867589 11 dbSNP
rs1399588338 15 dbSNP
rs1219969167 16 dbSNP
rs1265084977 18 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol WEE1   
Synonyms WEE1A, WEE1hu
Description WEE1 G2 checkpoint kinase
Transcript NM_001143976   
Other Transcripts NM_003390   
Expression
Putative miRNA Targets on WEE1
3'UTR of WEE1
(miRNA target sites are highlighted)		 
>WEE1|NM_001143976|3'UTR
   1 GCTACTCCTTTCCCACCTCCCCCTGAACACTGTGACAAGAGGAAGCTAGGTTGAAATCACTGATAGAATCCAGTTTGCAA
  81 TTACTTTCTCGATTGGTGTCAGTAGTTTTACTGATTAGGACTTTTATTGTGAATTACAGTTGAAAGCTGTATTTTGATGA
 161 TTGCTATGTCAGGCTTTCATCTAATCTTACCAGTCTGTCTTCTGTAGGATGTGTCACTGTTGGATGTTACACCAGCCTTT
 241 CCAGGGTTAACCACTGTGGTGGTGTGCTGCTTATAGTTTGCTGTTGCATTGTAATAAAAGGTGTCTTTCCCTGTAGTGAC
 321 CTGTAAAAAGTACTCAAGGGCTTTATTACAGACATACCCTCCCTTTGAAAAGGGACATGCTAAAAGACTCATTACTACTC
 401 AGCCTTCAATGTACCTGTGTGTCCATCTTATATTTCTTTTTTTTTTAATTGTGAATTAGACTTGTATATCCCACTGGGAG
 481 CACTTTGTAGGCATTGCATGAACCATGGGATGATGATTCTGTGGAGGTATTGCCTTGTGAATTTGCTGCTATTTTAGTTT
 561 TGTCTTTGCTGTAAACTTGTAGCATTAAACAATCATTGTTGTTAATAGGTCTTCTTTTTGAAACAATTATGTGAAATGTA
 641 TAGCTGCTTTTGATGAAAAGCAGCTATTTGCCTTTTTTTTTTTTTCCTTTGAACTTTGAAGCTAGTGCATTGGAAAAATG
 721 CACCCTTTCCCTCCTTTGGAATGCTGTATTAATGTAGTATAATAATTACTGGTTTTGTAACTTGTTCTGGTAATGTCCTT
 801 CCCGGACTCTTTTTAAATGTCTCCCCCTAAGTTTTATACTTGATTGTATTATTAGTCTGTTTTTAAATGTTTTGCCCGGT
 881 TTTTCTCTTCAATATTTGTGTATATAAACCGATCTTCGTGATACTGTACATAGCTGTTTGAAATGCCAGAATGACTTCTG
 961 ACATTCCAAGTTTTTCACAAAATATATTTTATCTGTGATTAGCCATTTGACTAATAATACTGGCTAACAGATGTTGAAAA
1041 AAATTGTCTGTTTGTTTTCTCATTAATTTTGGTCTAAAACATGTTTGCACTTGTCTTTGACTTGTGTTTTATTAACATTG
1121 ATTGGCATATTAAAAGTCACTCTGAGCTTACCTTAATTGTCTAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' cuuuCUGUCAUCU-AACAUAUc 5'
              || | |||| ||||||| 
Target 5' ttgtGA-ATTAGACTTGTATAt 3'
 449 - 469 156.00 -5.60
2 
miRNA  3' cuUUC----UGUCAUCUAACAUAuc 5'
            |||    |:| | ||||||||  
Target 5' ctAAGTTTTATACTTGATTGTATta 3'
 827 - 851 141.00 -6.60
3 
miRNA  3' cuUUCUGU-----CAUCUAACAUAUc 5'
            :| |||     ||: | |||||| 
Target 5' ttGAAACAATTATGTGAAATGTATAg 3'
 618 - 643 123.00 -6.90
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30449243 9 COSMIC
COSN30162114 13 COSMIC
COSN30663006 16 COSMIC
COSN30100582 69 COSMIC
COSN30529547 86 COSMIC
COSN30155750 89 COSMIC
COSN31525104 125 COSMIC
COSN31594923 127 COSMIC
COSN31522421 237 COSMIC
COSN31590162 272 COSMIC
COSN23066642 326 COSMIC
COSN23076339 327 COSMIC
COSN26112696 346 COSMIC
COSN7293499 437 COSMIC
COSN20107961 447 COSMIC
COSN27512625 447 COSMIC
COSN26559221 460 COSMIC
COSN31535728 533 COSMIC
COSN25300466 596 COSMIC
COSN8286498 598 COSMIC
COSN31590169 600 COSMIC
COSN18723337 686 COSMIC
COSN20107963 686 COSMIC
COSN27552291 686 COSMIC
COSN7293503 810 COSMIC
COSN15738080 992 COSMIC
COSN31541840 1045 COSMIC
COSN20107965 1055 COSMIC
COSN26577629 1102 COSMIC
COSN29467337 1120 COSMIC
COSN26552244 1140 COSMIC
COSN29144415 1191 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1253049033 2 dbSNP
rs1380942069 3 dbSNP
rs376918551 6 dbSNP
rs746339662 12 dbSNP
rs1040315042 13 dbSNP
rs1161917803 15 dbSNP
rs772545414 20 dbSNP
rs559821398 21 dbSNP
rs761462789 23 dbSNP
rs764815770 30 dbSNP
rs1310890858 31 dbSNP
rs770854702 31 dbSNP
rs766054394 37 dbSNP
rs776776793 37 dbSNP
rs772733810 41 dbSNP
rs898648767 49 dbSNP
rs762412100 52 dbSNP
rs1311350444 56 dbSNP
rs1411583595 60 dbSNP
rs931524860 62 dbSNP
rs929380682 72 dbSNP
rs1306817151 80 dbSNP
rs865955619 85 dbSNP
rs754888514 89 dbSNP
rs553359817 91 dbSNP
rs542331153 92 dbSNP
rs1281935535 99 dbSNP
rs1422934845 102 dbSNP
rs149282089 112 dbSNP
rs1184788330 113 dbSNP
rs906074281 115 dbSNP
rs1251759479 117 dbSNP
rs759100193 123 dbSNP
rs1489489945 125 dbSNP
rs1041084884 141 dbSNP
rs901730965 157 dbSNP
rs1330157026 167 dbSNP
rs996482827 168 dbSNP
rs1028933938 173 dbSNP
rs1034662993 179 dbSNP
rs1271906257 191 dbSNP
rs1306162860 193 dbSNP
rs960755532 201 dbSNP
rs1437593786 205 dbSNP
rs779089246 210 dbSNP
rs1291348453 214 dbSNP
rs542356383 222 dbSNP
rs1457034393 224 dbSNP
rs1388933192 230 dbSNP
rs1021236337 247 dbSNP
rs968284969 247 dbSNP
rs1411744077 253 dbSNP
rs531145889 255 dbSNP
rs1265354008 259 dbSNP
rs979358665 263 dbSNP
rs1000740651 264 dbSNP
rs1030675853 275 dbSNP
rs1270284796 334 dbSNP
rs1207102145 338 dbSNP
rs753258844 346 dbSNP
rs1240571270 352 dbSNP
rs1233870505 354 dbSNP
rs1440852254 354 dbSNP
rs1183003739 355 dbSNP
rs956458923 357 dbSNP
rs991763972 378 dbSNP
rs964567579 383 dbSNP
rs1439548480 385 dbSNP
rs1365425559 389 dbSNP
rs1366820884 401 dbSNP
rs758840115 403 dbSNP
rs143502910 404 dbSNP
rs1455364417 405 dbSNP
rs751898917 410 dbSNP
rs757591885 411 dbSNP
rs1419146116 414 dbSNP
rs1047797599 425 dbSNP
rs1198193288 431 dbSNP
rs1188644183 437 dbSNP
rs139009920 437 dbSNP
rs920221141 446 dbSNP
rs141541085 447 dbSNP
rs931436959 447 dbSNP
rs570805549 448 dbSNP
rs1400866018 449 dbSNP
rs1451847250 452 dbSNP
rs533485978 455 dbSNP
rs1341713399 460 dbSNP
rs1244951095 461 dbSNP
rs1432440679 471 dbSNP
rs1325495211 481 dbSNP
rs1335206258 492 dbSNP
rs1398180676 493 dbSNP
rs908602869 495 dbSNP
rs1173536476 498 dbSNP
rs1431011195 500 dbSNP
rs1392097202 520 dbSNP
rs1166797007 531 dbSNP
rs1449026053 539 dbSNP
rs1369289148 541 dbSNP
rs1315753750 548 dbSNP
rs1217115408 553 dbSNP
rs1253879366 558 dbSNP
rs1210058928 572 dbSNP
rs944116406 573 dbSNP
rs1041177929 574 dbSNP
rs1260415043 581 dbSNP
rs546172356 583 dbSNP
rs1225568381 588 dbSNP
rs1338290968 592 dbSNP
rs749523604 595 dbSNP
rs1200419331 596 dbSNP
rs1246593685 596 dbSNP
rs1312720300 602 dbSNP
rs1372960258 604 dbSNP
rs1410904198 604 dbSNP
rs1306205254 607 dbSNP
rs1254747157 608 dbSNP
rs768795097 610 dbSNP
rs867490165 612 dbSNP
rs896142190 624 dbSNP
rs1009767335 627 dbSNP
rs899815933 632 dbSNP
rs1186969780 638 dbSNP
rs1020701580 639 dbSNP
rs1253919935 639 dbSNP
rs147995463 641 dbSNP
rs1202364081 642 dbSNP
rs1436698356 642 dbSNP
rs967734211 646 dbSNP
rs1211257380 653 dbSNP
rs535171306 654 dbSNP
rs1293002282 656 dbSNP
rs1049403 657 dbSNP
rs1352824135 667 dbSNP
rs1286965580 673 dbSNP
rs1350530175 673 dbSNP
rs368710857 673 dbSNP
rs397848312 673 dbSNP
rs77937016 673 dbSNP
rs1394049112 686 dbSNP
rs200750136 686 dbSNP
rs1424105786 687 dbSNP
rs903777130 689 dbSNP
rs1469134834 691 dbSNP
rs1170722079 692 dbSNP
rs1404345051 693 dbSNP
rs1001069917 697 dbSNP
rs1030811630 698 dbSNP
rs976011048 706 dbSNP
rs956430056 712 dbSNP
rs1317029052 714 dbSNP
rs1337888682 715 dbSNP
rs923297651 721 dbSNP
rs1246711896 723 dbSNP
rs771214888 726 dbSNP
rs1013277494 735 dbSNP
rs867315135 740 dbSNP
rs983817548 757 dbSNP
rs1272186046 760 dbSNP
rs1209008177 780 dbSNP
rs1024705740 785 dbSNP
rs1280446022 791 dbSNP
rs1319008930 792 dbSNP
rs1233055700 800 dbSNP
rs79294375 804 dbSNP
rs1347757164 817 dbSNP
rs1434434236 823 dbSNP
rs980469369 823 dbSNP
rs942064386 827 dbSNP
rs1321430822 839 dbSNP
rs1201048731 843 dbSNP
rs1262593822 846 dbSNP
rs920129956 852 dbSNP
rs10534 860 dbSNP
rs776667386 868 dbSNP
rs927426932 877 dbSNP
rs1156669099 878 dbSNP
rs982918420 879 dbSNP
rs1264237221 884 dbSNP
rs538045939 893 dbSNP
rs938961494 903 dbSNP
rs746006691 906 dbSNP
rs1196566554 908 dbSNP
rs944211107 910 dbSNP
rs1451997629 911 dbSNP
rs780269087 918 dbSNP
rs921383125 919 dbSNP
rs932611059 920 dbSNP
rs896181867 922 dbSNP
rs1379232852 923 dbSNP
rs1043065542 925 dbSNP
rs147130750 956 dbSNP
rs1313253127 963 dbSNP
rs577989100 970 dbSNP
rs903627619 985 dbSNP
rs191119627 991 dbSNP
rs1000550485 998 dbSNP
rs1052332245 1006 dbSNP
rs892284571 1014 dbSNP
rs1286847285 1015 dbSNP
rs1359566619 1029 dbSNP
rs1336064842 1032 dbSNP
rs1432847642 1040 dbSNP
rs1393954276 1044 dbSNP
rs1358110154 1045 dbSNP
rs1168681881 1047 dbSNP
rs202068253 1049 dbSNP
rs79680752 1049 dbSNP
rs200938961 1053 dbSNP
rs1013414066 1055 dbSNP
rs1024644076 1063 dbSNP
rs1186256536 1067 dbSNP
rs1483767066 1068 dbSNP
rs904940921 1073 dbSNP
rs553377220 1082 dbSNP
rs1485631781 1090 dbSNP
rs1002253117 1091 dbSNP
rs997880967 1096 dbSNP
rs78738598 1101 dbSNP
rs73408237 1102 dbSNP
rs1344548047 1103 dbSNP
rs1026662912 1111 dbSNP
rs952512028 1113 dbSNP
rs983013060 1114 dbSNP
rs1229150018 1117 dbSNP
rs1379605942 1117 dbSNP
rs1285806253 1128 dbSNP
rs1015892380 1131 dbSNP
rs1412788422 1153 dbSNP
rs1374785865 1155 dbSNP
rs965528254 1162 dbSNP
rs976927208 1164 dbSNP
rs1169287858 1173 dbSNP
rs983484267 1174 dbSNP
rs1416321048 1189 dbSNP
rs771911373 1191 dbSNP
rs921309979 1195 dbSNP
rs1234640471 1196 dbSNP
rs932771980 1198 dbSNP
rs1285974786 1200 dbSNP
rs1186270285 1205 dbSNP
rs1016249342 1208 dbSNP
rs1253203532 1216 dbSNP
rs1207970219 1218 dbSNP
rs1479685613 1221 dbSNP
rs979143472 1225 dbSNP
rs1222577891 1227 dbSNP
rs763434021 1228 dbSNP
rs1294837869 1238 dbSNP
rs1231252893 1245 dbSNP
rs773165281 1248 dbSNP
rs1354697865 1251 dbSNP
rs925965720 1256 dbSNP
rs1218967607 1259 dbSNP
rs760413867 1262 dbSNP
rs927480628 1264 dbSNP
rs938861310 1272 dbSNP
rs1488282858 1278 dbSNP
rs1351275125 1283 dbSNP
rs1189188857 1284 dbSNP
rs1461222593 1291 dbSNP
rs544466948 1298 dbSNP
rs892419869 1299 dbSNP
rs1417922684 1300 dbSNP
rs949180665 1302 dbSNP
rs1433663477 1315 dbSNP
rs550636699 1318 dbSNP
rs1191862063 1321 dbSNP
rs1042058355 1329 dbSNP
rs1378459769 1333 dbSNP
rs776329008 1333 dbSNP
rs573205730 1337 dbSNP
rs1271541538 1343 dbSNP
rs1440994489 1344 dbSNP
rs936457094 1348 dbSNP
rs1038755745 1350 dbSNP
rs1268594118 1364 dbSNP
rs567054958 1368 dbSNP
rs1315067738 1369 dbSNP
rs904910909 1370 dbSNP
rs1386871042 1371 dbSNP
rs1001946623 1375 dbSNP
rs1027172567 1379 dbSNP
rs1323450019 1382 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Disease 7465.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM1065668. RNA binding protein: AGO1. Condition:4-thiouridine ...

- Memczak S; Jens M; Elefsinioti A; Torti F; et al., 2013, Nature.

Article - Memczak S; Jens M; Elefsinioti A; Torti F; et al.
- Nature, 2013
Circular RNAs (circRNAs) in animals are an enigmatic class of RNA with unknown function. To explore circRNAs systematically, we sequenced and computationally analysed human, mouse and nematode RNA. We detected thousands of well-expressed, stable circRNAs, often showing tissue/developmental-stage-specific expression. Sequence analysis indicated important regulatory functions for circRNAs. We found that a human circRNA, antisense to the cerebellar degeneration-related protein 1 transcript (CDR1as), is densely bound by microRNA (miRNA) effector complexes and harbours 63 conserved binding sites for the ancient miRNA miR-7. Further analyses indicated that CDR1as functions to bind miR-7 in neuronal tissues. Human CDR1as expression in zebrafish impaired midbrain development, similar to knocking down miR-7, suggesting that CDR1as is a miRNA antagonist with a miRNA-binding capacity ten times higher than any other known transcript. Together, our data provide evidence that circRNAs form a large class of post-transcriptional regulators. Numerous circRNAs form by head-to-tail splicing of exons, suggesting previously unrecognized regulatory potential of coding sequences.
LinkOut: [PMID: 23446348]
CLIP-seq Support 1 for dataset GSM1065668
Method / RBP PAR-CLIP / AGO1
Cell line / Condition HEK293 / 4-thiouridine, ML_MM_7
Location of target site ENST00000299613.6 | 3UTR | AUAUCCCACUGGGAGCACUUU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23446348 / GSE43573
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
KIRC -0.4 0 -0.363 0 68 Click to see details
PCPG -0.998 0.02 -1.000 0.5 3 Click to see details
LIHC 0.269 0.03 0.335 0.01 49 Click to see details
HNSC 0.267 0.04 0.361 0.01 42 Click to see details
STAD -0.301 0.05 -0.313 0.04 32 Click to see details
LUSC 0.225 0.09 0.190 0.13 38 Click to see details
KIRP 0.223 0.11 0.262 0.07 32 Click to see details
CESC -0.894 0.15 -1.000 0.5 3 Click to see details
COAD -0.689 0.16 -1.000 0.5 4 Click to see details
LUAD 0.271 0.2 0.308 0.17 12 Click to see details
PRAD -0.115 0.21 -0.161 0.13 50 Click to see details
UCEC -0.181 0.23 -0.302 0.1 19 Click to see details
BRCA 0.077 0.24 0.044 0.35 84 Click to see details
ESCA -0.232 0.25 -0.027 0.47 11 Click to see details
THCA 0.083 0.27 0.043 0.37 59 Click to see details
BLCA 0.094 0.36 0.179 0.24 18 Click to see details
PAAD 0.277 0.36 0.200 0.4 4 Click to see details
CHOL -0.109 0.39 0.000 0.5 9 Click to see details
KICH 0.018 0.47 0.013 0.48 25 Click to see details
KICH 0.018 0.47 0.013 0.48 25 Click to see details
121 hsa-let-7a-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT038998 ARMC8 armadillo repeat containing 8 1 1
MIRT038999 SETD4 SET domain containing 4 1 1
MIRT039000 BTF3 basic transcription factor 3 1 1
MIRT039001 MIPOL1 mirror-image polydactyly 1 1 1
MIRT039002 TRIM33 tripartite motif containing 33 1 1
MIRT039003 CS citrate synthase 1 1
MIRT039004 SENP7 SUMO1/sentrin specific peptidase 7 1 1
MIRT055418 SHOC2 SHOC2, leucine rich repeat scaffold protein 2 10
MIRT057681 LCOR ligand dependent nuclear receptor corepressor 2 8
MIRT061351 WEE1 WEE1 G2 checkpoint kinase 2 2
MIRT062174 WNK1 WNK lysine deficient protein kinase 1 2 2
MIRT071813 RNF11 ring finger protein 11 2 2
MIRT091374 EIF4A2 eukaryotic translation initiation factor 4A2 2 2
MIRT095107 SEC24A SEC24 homolog A, COPII coat complex component 2 2
MIRT098814 PPIL4 peptidylprolyl isomerase like 4 2 2
MIRT109534 KLHL15 kelch like family member 15 2 4
MIRT120263 GSK3B glycogen synthase kinase 3 beta 2 2
MIRT149839 LDLR low density lipoprotein receptor 2 6
MIRT164519 MSMO1 methylsterol monooxygenase 1 2 2
MIRT165879 CREBRF CREB3 regulatory factor 2 2
MIRT169899 HBP1 HMG-box transcription factor 1 2 4
MIRT182779 TOR1AIP2 torsin 1A interacting protein 2 2 2
MIRT193466 RORA RAR related orphan receptor A 2 2
MIRT226421 TP53INP1 tumor protein p53 inducible nuclear protein 1 2 2
MIRT334410 CREBZF CREB/ATF bZIP transcription factor 2 6
MIRT338286 SYF2 SYF2 pre-mRNA splicing factor 2 2
MIRT361627 TES testin LIM domain protein 2 2
MIRT406687 ZNF181 zinc finger protein 181 2 2
MIRT407768 MRPL35 mitochondrial ribosomal protein L35 2 2
MIRT449468 HAT1 histone acetyltransferase 1 2 2
MIRT467110 SRI sorcin 2 2
MIRT475099 IRF2BP2 interferon regulatory factor 2 binding protein 2 2 6
MIRT481671 ARAP2 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 2 2
MIRT493061 MTFR1 mitochondrial fission regulator 1 2 2
MIRT497923 BTG1 BTG anti-proliferation factor 1 2 2
MIRT498202 ACVR2B activin A receptor type 2B 2 2
MIRT503391 ASB11 ankyrin repeat and SOCS box containing 11 2 6
MIRT503862 UBXN2B UBX domain protein 2B 2 2
MIRT504368 ARID1B AT-rich interaction domain 1B 2 4
MIRT504991 ZNF652 zinc finger protein 652 2 2
MIRT505754 SENP1 SUMO1/sentrin specific peptidase 1 2 8
MIRT518102 ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide 2 6
MIRT521930 PHF8 PHD finger protein 8 2 4
MIRT522139 NRBF2 nuclear receptor binding factor 2 2 6
MIRT522401 MYADM myeloid associated differentiation marker 2 4
MIRT523593 FZD5 frizzled class receptor 5 2 4
MIRT523944 E2F8 E2F transcription factor 8 2 4
MIRT524355 CREB1 cAMP responsive element binding protein 1 2 2
MIRT525140 ZNF256 zinc finger protein 256 2 2
MIRT527070 ABCC4 ATP binding cassette subfamily C member 4 2 2
MIRT527486 OCIAD1 OCIA domain containing 1 2 2
MIRT528129 PPP1R10 protein phosphatase 1 regulatory subunit 10 2 2
MIRT530528 ALG10B ALG10B, alpha-1,2-glucosyltransferase 2 2
MIRT531270 PPIL3 peptidylprolyl isomerase like 3 2 2
MIRT538898 BRI3BP BRI3 binding protein 2 2
MIRT541371 CDKN1B cyclin dependent kinase inhibitor 1B 2 2
MIRT541526 MGAT4C MGAT4 family member C 2 2
MIRT543776 RBM12B RNA binding motif protein 12B 2 4
MIRT543946 NCOA7 nuclear receptor coactivator 7 2 2
MIRT545156 GABRG1 gamma-aminobutyric acid type A receptor gamma1 subunit 2 2
MIRT545848 ZNF264 zinc finger protein 264 2 4
MIRT546064 VEZF1 vascular endothelial zinc finger 1 2 2
MIRT546481 SLC16A14 solute carrier family 16 member 14 2 4
MIRT551835 AASDHPPT aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 2 2
MIRT551901 ACP1 acid phosphatase 1, soluble 2 2
MIRT552490 ZNF136 zinc finger protein 136 2 2
MIRT554206 SLC35A5 solute carrier family 35 member A5 2 2
MIRT554295 SIPA1L2 signal induced proliferation associated 1 like 2 2 2
MIRT555765 PCTP phosphatidylcholine transfer protein 2 2
MIRT558315 DSG2 desmoglein 2 2 2
MIRT563147 NOLC1 nucleolar and coiled-body phosphoprotein 1 2 2
MIRT566464 PGGT1B protein geranylgeranyltransferase type I subunit beta 2 2
MIRT567322 HMGB2 high mobility group box 2 2 2
MIRT567738 DLX2 distal-less homeobox 2 2 2
MIRT567892 CSTF2 cleavage stimulation factor subunit 2 2 2
MIRT570087 KANSL1L KAT8 regulatory NSL complex subunit 1 like 2 2
MIRT571136 TTC33 tetratricopeptide repeat domain 33 2 2
MIRT573534 MDM2 MDM2 proto-oncogene 2 2
MIRT574465 RPS16 ribosomal protein S16 2 2
MIRT574998 Phka1 phosphorylase kinase alpha 1 2 3
MIRT610202 CD99 CD99 molecule (Xg blood group) 2 4
MIRT612926 GPRIN3 GPRIN family member 3 2 2
MIRT615027 DUSP6 dual specificity phosphatase 6 2 2
MIRT617200 GREM1 gremlin 1, DAN family BMP antagonist 2 2
MIRT628720 ZNF585A zinc finger protein 585A 2 2
MIRT641491 POLA2 DNA polymerase alpha 2, accessory subunit 2 2
MIRT641663 PAPOLG poly(A) polymerase gamma 2 2
MIRT642216 RUVBL2 RuvB like AAA ATPase 2 2 2
MIRT654589 PURA purine rich element binding protein A 2 2
MIRT656136 MSH6 mutS homolog 6 2 2
MIRT656899 KIAA2018 upstream transcription factor family member 3 2 2
MIRT660136 BRPF3 bromodomain and PHD finger containing 3 2 2
MIRT660861 AFAP1 actin filament associated protein 1 2 2
MIRT676849 PHKA1 phosphorylase kinase regulatory subunit alpha 1 2 3
MIRT681479 DIP2A disco interacting protein 2 homolog A 2 2
MIRT682259 RS1 retinoschisin 1 2 2
MIRT685602 MYOM2 myomesin 2 2 2
MIRT686943 SFT2D3 SFT2 domain containing 3 2 2
MIRT694302 COPB2 coatomer protein complex subunit beta 2 2 2
MIRT694407 ALDH1A3 aldehyde dehydrogenase 1 family member A3 2 2
MIRT697280 ZNF800 zinc finger protein 800 2 2
MIRT698414 TM4SF1 transmembrane 4 L six family member 1 2 2
MIRT698989 SPAG9 sperm associated antigen 9 2 2
MIRT699766 SEMA4D semaphorin 4D 2 2
MIRT699928 RUFY2 RUN and FYVE domain containing 2 2 2
MIRT702113 MBNL1 muscleblind like splicing regulator 1 2 2
MIRT702373 KLF10 Kruppel like factor 10 2 2
MIRT702646 ITGA3 integrin subunit alpha 3 2 2
MIRT705713 ANAPC16 anaphase promoting complex subunit 16 2 2
MIRT717925 ZNF546 zinc finger protein 546 2 2
MIRT720839 C1orf52 chromosome 1 open reading frame 52 2 2
MIRT725033 NDUFAF7 NADH:ubiquinone oxidoreductase complex assembly factor 7 2 2
MIRT731448 APOBEC3A apolipoprotein B mRNA editing enzyme catalytic subunit 3A 1 1
MIRT733217 CCNG1 cyclin G1 2 0
MIRT734887 LIN28B lin-28 homolog B 1 0
MIRT735276 HMGA2 high mobility group AT-hook 2 2 0
MIRT735727 SYNCRIP synaptotagmin binding cytoplasmic RNA interacting protein 3 0
MIRT736087 RCVRN recoverin 1 0
MIRT736088 RHO rhodopsin 1 0
MIRT736103 TLR7 toll like receptor 7 1 0
MIRT736607 TPO thyroid peroxidase 2 0
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
let-7a Caudatin NULL 21633059 Quantitative real-time PCR gastric carcinoma cell lines 23708208 2013 up-regualted
let-7a XMD8-92 NULL 46843772 Microarray pancreatic ductal adenocarcinoma cell 24880079 2014 up-regulated
let-7a Hydroxamic acid HDACi LAQ824 NULL NULL Microarray breast cancer cell line SKBr3 16452179 2006 down-regulated
let-7a Hydroxamic acid HDACi LAQ824 NULL NULL Northern blot breast cancer cell line SKBr3 16452180 2006 down-regulated
let-7a Trichostatin A (TSA) NULL 444732 Microarray human pancreatic cancer cell line BxPC-3 19112422 2009 down-regulated
let-7a 17beta-estradiol (E2) approved 5757 Microarray MCF-7 breast cancer cells 19528081 2009 up-regulated
let-7a Etoposide approved 36462 Microarray Normal human fibroblasts (AG01522) 19633716 2009 down-regulated
let-7a Etoposide approved 36462 Quantitative real-time PCR Normal human fibroblasts (AG01522) 19633716 2009 down-regulated
let-7a Polylysine NULL 162282 Quantitative real-time PCR 293T(FLAG AGO2) cells 20529860 2010 down-regulated
let-7a Trypaflavine NULL NULL Quantitative real-time PCR 293T(FLAG AGO2) cells 20529860 2010 down-regulated
let-7a Formaldehyde NULL 712 Microarray Human lung epithelial cells (A549) 21147603 2011 down-regulated
let-7a Enoxacin approved 3229 Northern blot HCT-116 and RKO colon cancer cell lines 21368194 2011 up-regulated
let-7a Enoxacin approved 3229 Quantitative real-time PCR HCT-116 and RKO colon cancer cell lines 21368194 2011 up-regulated
let-7a Metformin approved 4091 Quantitative real-time PCR MCF-7 human mammary cancer cell line 21368581 2011 up-regulated
let-7a 5-Fluorouracil approved 3385 Microarray MCF-7 breast cancer cells 21506117 2011 up-regulated
let-7a Arsenic trioxide approved 14888 Quantitative real-time PCR acute promyelocytic leukemia 22072212 2012 up-regulated
let-7a Metformin approved 4091 Quantitative real-time PCR pancreatic cancer cells 22086681 2012 up-regulated
let-7a Metformin approved 4091 Quantitative real-time PCR pancreatic cancer cells 22086681 2012 up-regulated
let-7a CDF(analogues of curcumin) NULL NULL Quantitative real-time PCR pancreatic cancer cells 22108826 2012 up-regulated
let-7a Marine fungal metabolite 1386A NULL NULL Microarray MCF-7 breast cancer cells. 22159329 2012 down-regulated
let-7a Curcumin NULL 969516 Quantitative real-time PCR esophageal cancer cells 22363450 2012 up-regulated
let-7a 1,2,6-Tri-O-galloyl-beta-D-glucopyranose NULL NULL Microarray HepG2 hepatocarcinoma cells. 22506400 2011 up-regulated
let-7a Vitamin D3 approved 5280795 Quantitative real-time PCR Plasma 22594500 2012 up-regulated
let-7a Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) NULL 8490 Microarray mouse liver 19270793 2009 down-regulated
let-7a Budesonide approved 5281004 Microarray neonatal mice liver 20145010 2010 up-regulated
let-7a Budesonide approved 5281004 Microarray neonatal mice lung 20145010 2010 down-regulated
let-7a Phenethyl isothiocyanate(PEITC) NULL 16741 Microarray neonatal mice lung 20145010 2010 up-regulated
let-7a Dexamethasone approved 5743 Microarray primary rat thymocytes 20847043 2010 down-regulated
let-7a Dexamethasone approved 5743 Quantitative real-time PCR primary rat thymocytes 20847043 2010 down-regulated
let-7a Perfluorooctane sulfonate NULL 74483 Microarray zebrafish embryos 20878907 2011 up-regulated
let-7a Hydroxychloroquine approved 3652 Quantitative real-time PCR mesangial cells 24121037 2013 down-regualted
let-7a Prednisone approved 5865 Quantitative real-time PCR mesangial cells 24121037 2013 down-regualted
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-let-7a-3p Gemcitabine 60750 NSC613327 approved resistant High Cholangiocarcinoma cell line (HuCCT1, HuH28)
hsa-let-7a-3p Docetaxel 148124 NSC628503 approved sensitive High Breast Cancer cell line (MDA-MB-231, MCF-7)
hsa-let-7a-3p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-let-7a-3p Osimertinib 71496458 NSC779217 approved resistant cell line (HCC827)
hsa-let-7a-3p Osimertinib 71496458 NSC779217 approved resistant cell line (HCC827)
hsa-let-7a-3p Vemurafenib 42611257 NSC761431 approved sensitive cell line (451Lu)
hsa-let-7a-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A2780)
hsa-let-7a-3p Fluorouracil 3385 NSC19893 approved sensitive cell line (HCT15)
hsa-let-7a-3p 4-Hydroxytamoxifen+Tamoxifen resistant cell line (LY2)
hsa-let-7a-3p Oxaliplatin 6857599 NSC266046 approved resistant cell line (IGROV-1)
hsa-let-7a-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-let-7a-3p Neoadjuvant chemotherapy sensitive tissue (breast cancer)
hsa-let-7a-3p Paclitaxel/Docetaxel/Vinorelbine/Doxorubicin/Etoposide sensitive cell line (Bads-200)

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