| pre-miRNA Information | |
|---|---|
| pre-miRNA | hsa-mir-646 |
| Genomic Coordinates | chr20: 60308474 - 60308567 |
| Synonyms | MIRN646, hsa-mir-646, MIR646 |
| Description | Homo sapiens miR-646 stem-loop |
| Comment | None |
| RNA Secondary Structure |  |
| Associated Diseases |  |
| Mature miRNA Information | |||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Mature miRNA | hsa-miR-646 | ||||||||||||||||||||||||
| Sequence | 61| AAGCAGCUGCCUCUGAGGC |79 | ||||||||||||||||||||||||
| Evidence | Experimental | ||||||||||||||||||||||||
| Experiments | SAGE | ||||||||||||||||||||||||
| SNPs in miRNA |
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| Putative Targets | |||||||||||||||||||||||||
| miRNA Expression profile | |
|---|---|
| Human miRNA Tissue Atlas | |
| miRNAs in Extracellular Vesicles |
|
| Circulating MicroRNA Expression Profiling | |
| Gene Information | |||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Gene Symbol | BTG2 | ||||||||||||||||||||
| Synonyms | APRO1, PC3, TIS21 | ||||||||||||||||||||
| Description | BTG anti-proliferation factor 2 | ||||||||||||||||||||
| Transcript | NM_006763 | ||||||||||||||||||||
| Expression | |||||||||||||||||||||
| Putative miRNA Targets on BTG2 | |||||||||||||||||||||
| 3'UTR of BTG2 (miRNA target sites are highlighted) |
>BTG2|NM_006763|3'UTR 1 GCCCTTCCGCCCCCGCCCTGGGCGCCGCCGTGCTCATGCTGCCGTGACAACAGGCCACCACATACCTCAACCTGGGGAAC 81 TGTATTTTTAAATGAAGAGCTATTTATATATATTATTTTTTTTTAAGAAAGGAGGAAAAGAAACCAAAAGTTTTTTTTAA 161 GAAAAAAAATCCTTCAAGGGAGCTGCTTGGAAGTGGCCTCCCCAGGTGCCTTTGGAGAGAACTGTTGCGTGCTTGAGTCT 241 GTGAGCCAGTGTCTGCCTATAGGAGGGGGAGCTGTTAGGGGGTAGACCTAGCCAAGGAGAAGTGGGAGACGTTTGGCTAG 321 CACCCCAGGAAGATGTGAGAGGGAGCAAGCAAGGTTAGCAACTGTGAACAGAGAGGTCGGGATTTGCCCTGGGGGAGGAA 401 GAGAGGCCAAGTTCAGAGCTCTCTGTCTCCCCCAGCCAGACACCTGCATCCCTGGCTCCTCTATTACTCAGGGGCATTCA 481 TGCCTGGACTTAAACAATACTATGTTATCTTTTCTTTTATTTTTCTAATGAGGTCCTGGGCAGAGAGTGAAAAGGCCTCT 561 CCTGATTCCTACTGTCCTAAGCTGCTTTTCTTGAAATCATGACTTGTTTCTAATTCTACCCTCAGGGGCCTGTAGATGTT 641 GCTTTCCAGCCAGGAATCTAAAGCTTTGGGTTTTCTGAGGGGGGGGAGGAGGGAACTGGAGGTTATTGGGGTTAGGATGG 721 AAGGGAACTCTGCACAAAACCTTTGCTTTGCTAGTGCTGCTTTGTGTGTATGTGTGGCAAATAATTTGGGGGTGATTTGC 801 AATGAAATTTTGGGACCCAAAGAGTATCCACTGGGGATGTTTTTTGGCCAAAACTCTTCCTTTTGGAACCACATGAAAGT 881 CTTGATGCTGCTGCCATGATCCCTTTGAGAGGTGGCTCAAAAGCTACAGGGAACTCCAGGTCCTTTATTACTGCCTTCTT 961 TTCAAAAGCACAACTCTCCTCTAACCCTCCCCTCCCCCTTCCCTTCTGGTCGGGTCATAGAGCTACCGTATTTTCTAGGA 1041 CAAGAGTTCTCAGTCACTGTGCAATATGCCCCCTGGGTCCCAGGAGGGTCTGGAGGAAAACTGGCTATCAGAACCTCCTG 1121 ATGCCCTGGTGGGCTTAGGGAACCATCTCTCCTGCTCTCCTTGGGATGATGGCTGGCTAGTCAGCCTTGCATGTATTCCT 1201 TGGCTGAATGGGAGAGTGCCCCATGTTCTGCAAGACTACTTGGTATTCTTGTAGGGCCGACACTAAATAAAAGCCAAACC 1281 TTGGGCACTGTTTTTTCTCCCTGGTGCTCAGAGCACCTGTGGGAAAGGTTGCTGTCTGTCTCAGTACAATCCAAATTTGT 1361 CGTAGACTTGTGCAATATATACTGTTGTGGGTTGGAGAAAAGTGGAAAGCTACACTGGGAAGAAACTCCCTTCCTTCAAT 1441 TTCTCAGTGACATTGATGAGGGGTCCTCAAAAGACCTCGAGTTTCCCAAACCGAATCACCTTAAGAAGGACAGGGCTAGG 1521 GCATTTGGCCAGGATGGCCACCCTCCTGCTGTTGCCCCTTAGTGAGGAATCTTCACCCCACTTCCTCTACCCCCAGGTTC 1601 TCCTCCCCACAGCCAGTCCCCTTTCCTGGATTTCTAAACTGCTCAATTTTGACTCAAAGGTGCTATTTACCAAACACTCT 1681 CCCTACCCATTCCTGCCAGCTCTGCCTCCTTTTCAACTCTCCACATTTTGTATTGCCTTCCCAGACCTGCTTCCAGTCTT 1761 TATTGCTTTAAAGTTCACTTTGGGCCCACAGACCCAAGAGCTAATTTTCTGGTTTGTGGGTTGAAACAAAGCTGTGAATC 1841 ACTGCAGGCTGTGTTCTTGCATCTTGTCTGCAAACAGGTCCCTGCCTTTTTAGAAGCAGCCTCATGGTCTCATGCTTAAT 1921 CTTGTCTCTCTTCTCTTCTTTATGATGTTCACTTTAAAAACAACAAAACCCCTGAGCTGGACTGTTGAGCAGGCCTGTCT 2001 CTCCTATTAAGTAAAAATAAATAGTAGTAGTATGTTTGTAAGCTATTCTGACAGAAAAGACAAAGGTTACTAATTGTATG 2081 ATAGTGTTTTTATATGGAAGAATGTACAGCTTATGGACAAATGTACACCTTTTTGTTACTTTAATAAAAATGTAGTAGGA 2161 TAAAAAAAAA Target sites
Provided by authors
Predicted by miRanda
DRVs
SNPs
DRVs & SNPs
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| miRNA-target interactions (Predicted by miRanda) |
|
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| DRVs in gene 3'UTRs | |||||||||||||||||||||
| SNPs in gene 3'UTRs | |||||||||||||||||||||
| Experimental Support 1 for Functional miRNA-Target Interaction | |||||||
|---|---|---|---|---|---|---|---|
| miRNA:Target | ---- | ||||||
| Validation Method |
|
||||||
| Conditions | HEK293 | ||||||
| Location of target site | 3'UTR | ||||||
| Tools used in this research | TargetScan , miRTarCLIP , Piranha | ||||||
| Original Description (Extracted from the article) |
...
PAR-CLIP data was present in GSM545216. RNA binding protein: AGO2. Condition:miR-124 transfection
... - Hafner M; Landthaler M; Burger L; Khorshid et al., 2010, Cell. |
||||||
| miRNA-target interactions (Provided by authors) |
|
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| Article |
- Hafner M; Landthaler M; Burger L; Khorshid et al. - Cell, 2010
RNA transcripts are subject to posttranscriptional gene regulation involving hundreds of RNA-binding proteins (RBPs) and microRNA-containing ribonucleoprotein complexes (miRNPs) expressed in a cell-type dependent fashion. We developed a cell-based crosslinking approach to determine at high resolution and transcriptome-wide the binding sites of cellular RBPs and miRNPs. The crosslinked sites are revealed by thymidine to cytidine transitions in the cDNAs prepared from immunopurified RNPs of 4-thiouridine-treated cells. We determined the binding sites and regulatory consequences for several intensely studied RBPs and miRNPs, including PUM2, QKI, IGF2BP1-3, AGO/EIF2C1-4 and TNRC6A-C. Our study revealed that these factors bind thousands of sites containing defined sequence motifs and have distinct preferences for exonic versus intronic or coding versus untranslated transcript regions. The precise mapping of binding sites across the transcriptome will be critical to the interpretation of the rapidly emerging data on genetic variation between individuals and how these variations contribute to complex genetic diseases.
LinkOut: [PMID: 20371350]
|
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| Experimental Support 2 for Functional miRNA-Target Interaction | |||||||
|---|---|---|---|---|---|---|---|
| miRNA:Target | ---- | ||||||
| Validation Method |
|
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| Conditions | MCF7 | ||||||
| Location of target site | 3'UTR | ||||||
| Tools used in this research | TargetScan , miRTarCLIP , Piranha | ||||||
| Original Description (Extracted from the article) |
...
PAR-CLIP data was present in SRR1045082. RNA binding protein: AGO2. Condition:Untreated
... - Farazi TA; Ten Hoeve JJ; Brown M; et al., 2014, Genome biology. |
||||||
| miRNA-target interactions (Provided by authors) |
|
||||||
| Article |
- Farazi TA; Ten Hoeve JJ; Brown M; et al. - Genome biology, 2014
BACKGROUND: Various microRNAs (miRNAs) are up- or downregulated in tumors. However, the repression of cognate miRNA targets responsible for the phenotypic effects of this dysregulation in patients remains largely unexplored. To define miRNA targets and associated pathways, together with their relationship to outcome in breast cancer, we integrated patient-paired miRNA-mRNA expression data with a set of validated miRNA targets and pathway inference. RESULTS: To generate a biochemically-validated set of miRNA-binding sites, we performed argonaute-2 photoactivatable-ribonucleoside-enhanced crosslinking and immunoprecipitation (AGO2-PAR-CLIP) in MCF7 cells. We then defined putative miRNA-target interactions using a computational model, which ranked and selected additional TargetScan-predicted interactions based on features of our AGO2-PAR-CLIP binding-site data. We subselected modeled interactions according to the abundance of their constituent miRNA and mRNA transcripts in tumors, and we took advantage of the variability of miRNA expression within molecular subtypes to detect miRNA repression. Interestingly, our data suggest that miRNA families control subtype-specific pathways; for example, miR-17, miR-19a, miR-25, and miR-200b show high miRNA regulatory activity in the triple-negative, basal-like subtype, whereas miR-22 and miR-24 do so in the HER2 subtype. An independent dataset validated our findings for miR-17 and miR-25, and showed a correlation between the expression levels of miR-182 targets and overall patient survival. Pathway analysis associated miR-17, miR-19a, and miR-200b with leukocyte transendothelial migration. CONCLUSIONS: We combined PAR-CLIP data with patient expression data to predict regulatory miRNAs, revealing potential therapeutic targets and prognostic markers in breast cancer.
LinkOut: [PMID: 24398324]
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| Experimental Support 3 for Functional miRNA-Target Interaction | |
|---|---|
| miRNA:Target | ---- |
| Validation Method |
|
| Conditions | HCT116 |
| Location of target site | 3'UTR |
| Tools used in this research | TargetScan , miRTarCLIP , Piranha |
| Original Description (Extracted from the article) |
...
PAR-CLIP data was present in ERX177632. RNA binding protein: AGO2. Condition:p53_V_AGO_CLIP_4_10
... - Krell J; Stebbing J; Carissimi C; Dabrowska et al., 2016, Genome research. |
| Article |
- Krell J; Stebbing J; Carissimi C; Dabrowska et al. - Genome research, 2016
DNA damage activates TP53-regulated surveillance mechanisms that are crucial in suppressing tumorigenesis. TP53 orchestrates these responses directly by transcriptionally modulating genes, including microRNAs (miRNAs), and by regulating miRNA biogenesis through interacting with the DROSHA complex. However, whether the association between miRNAs and AGO2 is regulated following DNA damage is not yet known. Here, we show that, following DNA damage, TP53 interacts with AGO2 to induce or reduce AGO2's association of a subset of miRNAs, including multiple let-7 family members. Furthermore, we show that specific mutations in TP53 decrease rather than increase the association of let-7 family miRNAs, reducing their activity without preventing TP53 from interacting with AGO2. This is consistent with the oncogenic properties of these mutants. Using AGO2 RIP-seq and PAR-CLIP-seq, we show that the DNA damage-induced increase in binding of let-7 family members to the RISC complex is functional. We unambiguously determine the global miRNA-mRNA interaction networks involved in the DNA damage response, validating them through the identification of miRNA-target chimeras formed by endogenous ligation reactions. We find that the target complementary region of the let-7 seed tends to have highly fixed positions and more variable ones. Additionally, we observe that miRNAs, whose cellular abundance or differential association with AGO2 is regulated by TP53, are involved in an intricate network of regulatory feedback and feedforward circuits. TP53-mediated regulation of AGO2-miRNA interaction represents a new mechanism of miRNA regulation in carcinogenesis.
LinkOut: [PMID: 26701625]
|
| CLIP-seq Support 1 for dataset GSM4903825 | |
|---|---|
| Method / RBP | HITS-CLIP / AGO |
| Cell line / Condition | Dermal fibroblasts / PID14_NS |
| Location of target site | NM_006763 | 3UTR | AAGAAAAAAAAUCCUUCAAGGGAGCUGCUUGGAAGUGGCCUCCCCAGGUGCCUUUGGAGAGAACUGUUGCGUGCUUGAGUCUGUGAGCCAGUGUCUGCCUAUAGGAGGGGGAGCUGUUAGGGGGUAGACCUAGCCAAGGAGAAGUGGGAGACGUUUGGCUAGCACCCCAGGAAGAUGUGAGAGGGAGCAAGCAAGGUUAGCAACUGUGAACAGAG |
| Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
| Accession Series | GSE161237 |
| CLIP-seq Viewer | Link |
| CLIP-seq Support 2 for dataset GSM4903828 | |
|---|---|
| Method / RBP | HITS-CLIP / AGO |
| Cell line / Condition | Dermal fibroblasts / PID21_9124 |
| Location of target site | NM_006763 | 3UTR | CUUCAAGGGAGCUGCUUGGAAGUGGCCUCCCCAGGUGCCUUUGGAGAGAACUGUUGCGUGCUU |
| Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
| Accession Series | GSE161237 |
| CLIP-seq Viewer | Link |
| CLIP-seq Support 3 for dataset GSM545216 | |
|---|---|
| Method / RBP | PAR-CLIP / AGO2 |
| Cell line / Condition | HEK293 / miR-124 transfection |
| Location of target site | ENST00000290551.4 | 3UTR | AUUCCUACUGUCCUAAGCUGCUUUUCU |
| Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
| Article / Accession Series | PMID: 20371350 / GSE21578 |
| CLIP-seq Viewer | Link |
| CLIP-seq Support 4 for dataset SRR1045082 | |
|---|---|
| Method / RBP | PAR-CLIP / AGO2 |
| Cell line / Condition | MCF7 / Untreated |
| Location of target site | ENST00000290551.4 | 3UTR | AUUCCUACUGUCCUAAGCUGCUUUUCUUG |
| Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
| Article / Accession Series | PMID: 24398324 / SRX388831 |
| CLIP-seq Viewer | Link |
| MiRNA-Target Expression Profile | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
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| MiRNA-Target Expression Profile (TCGA) | |||||||
|---|---|---|---|---|---|---|---|
|
243 hsa-miR-646 Target Genes:
Functional analysis:
ID |
Target | Description | Validation methods |
 |
 |
|||||||
| Strong evidence | Less strong evidence | |||||||||||
 |
 |
 |
 |
 |
 |
 |
 |
|||||
| MIRT061535 | BTG2 | BTG anti-proliferation factor 2 |  |
|
2 | 4 | ||||||
| MIRT064692 | CCND2 | cyclin D2 | |
|
2 | 4 | ||||||
| MIRT068834 | FNDC3A | fibronectin type III domain containing 3A | |
|
2 | 10 | ||||||
| MIRT079080 | BIRC5 | baculoviral IAP repeat containing 5 | |
|
2 | 6 | ||||||
| MIRT092735 | SETD5 | SET domain containing 5 | |
|
2 | 4 | ||||||
| MIRT093692 | PI4K2B | phosphatidylinositol 4-kinase type 2 beta | |
|
2 | 6 | ||||||
| MIRT096244 | CANX | calnexin | |
|
2 | 2 | ||||||
| MIRT096296 | SQSTM1 | sequestosome 1 | |
|
2 | 4 | ||||||
| MIRT098839 | PCMT1 | protein-L-isoaspartate (D-aspartate) O-methyltransferase | |
|
2 | 2 | ||||||
| MIRT100229 | PRR3 | proline rich 3 | |
|
2 | 4 | ||||||
| MIRT156479 | ATP5G3 | ATP synthase, H+ transporting, mitochondrial Fo complex subunit C3 (subunit 9) | |
|
2 | 2 | ||||||
| MIRT186378 | PNRC2 | proline rich nuclear receptor coactivator 2 | |
|
2 | 2 | ||||||
| MIRT196460 | TAOK1 | TAO kinase 1 | |
|
2 | 2 | ||||||
| MIRT211252 | FGF2 | fibroblast growth factor 2 | |
|
2 | 2 | ||||||
| MIRT215233 | NPM1 | nucleophosmin 1 | |
|
2 | 4 | ||||||
| MIRT215383 | CREBRF | CREB3 regulatory factor | |
|
2 | 2 | ||||||
| MIRT224972 | BAG4 | BCL2 associated athanogene 4 | |
|
2 | 4 | ||||||
| MIRT235598 | KIF3B | kinesin family member 3B | |
|
2 | 2 | ||||||
| MIRT249860 | CHAC1 | ChaC glutathione specific gamma-glutamylcyclotransferase 1 | |
|
2 | 2 | ||||||
| MIRT258407 | FOXK1 | forkhead box K1 | |
|
2 | 2 | ||||||
| MIRT269359 | WEE1 | WEE1 G2 checkpoint kinase | |
|
2 | 4 | ||||||
| MIRT310455 | REST | RE1 silencing transcription factor | |
|
2 | 2 | ||||||
| MIRT314057 | PIK3R1 | phosphoinositide-3-kinase regulatory subunit 1 | |
|
2 | 8 | ||||||
| MIRT322288 | SLC39A14 | solute carrier family 39 member 14 | |
|
2 | 2 | ||||||
| MIRT326311 | OCRL | OCRL, inositol polyphosphate-5-phosphatase | |
|
2 | 2 | ||||||
| MIRT329703 | SCD | stearoyl-CoA desaturase | |
|
2 | 2 | ||||||
| MIRT341278 | PABPN1 | poly(A) binding protein nuclear 1 | |
|
2 | 3 | ||||||
| MIRT403798 | AKIRIN1 | akirin 1 | |
|
2 | 2 | ||||||
| MIRT438549 | NOB1 | NIN1/PSMD8 binding protein 1 homolog | |
1 | 1 | |||||||
| MIRT441908 | SEPN1 | selenoprotein N | |
|
2 | 2 | ||||||
| MIRT444125 | ZNRF3 | zinc and ring finger 3 | |
|
2 | 2 | ||||||
| MIRT445458 | EXT1 | exostosin glycosyltransferase 1 | |
|
2 | 4 | ||||||
| MIRT446500 | ASCC1 | activating signal cointegrator 1 complex subunit 1 | |
|
2 | 2 | ||||||
| MIRT446538 | GOLGA8B | golgin A8 family member B | |
|
2 | 2 | ||||||
| MIRT447770 | DMRT2 | doublesex and mab-3 related transcription factor 2 | |
|
2 | 2 | ||||||
| MIRT448438 | TLL1 | tolloid like 1 | |
|
2 | 2 | ||||||
| MIRT448768 | GOLGA8A | golgin A8 family member A | |
|
2 | 2 | ||||||
| MIRT460749 | SRP14 | signal recognition particle 14 | |
|
2 | 2 | ||||||
| MIRT461556 | ACTR3B | ARP3 actin related protein 3 homolog B | |
|
2 | 2 | ||||||
| MIRT463163 | ZNF367 | zinc finger protein 367 | |
|
2 | 10 | ||||||
| MIRT464234 | VEGFA | vascular endothelial growth factor A | |
|
|
|
|
5 | 12 | |||
| MIRT464496 | UCK2 | uridine-cytidine kinase 2 | |
|
2 | 2 | ||||||
| MIRT465157 | TSC22D2 | TSC22 domain family member 2 | |
|
2 | 2 | ||||||
| MIRT466429 | TFAP2A | transcription factor AP-2 alpha | |
|
2 | 8 | ||||||
| MIRT467395 | SOCS5 | suppressor of cytokine signaling 5 | |
|
2 | 2 | ||||||
| MIRT468672 | SEC24A | SEC24 homolog A, COPII coat complex component | |
|
2 | 4 | ||||||
| MIRT469407 | REL | REL proto-oncogene, NF-kB subunit | |
|
2 | 6 | ||||||
| MIRT470750 | PNPLA6 | patatin like phospholipase domain containing 6 | |
|
2 | 2 | ||||||
| MIRT471947 | NR6A1 | nuclear receptor subfamily 6 group A member 1 | |
|
2 | 2 | ||||||
| MIRT472468 | NAPG | NSF attachment protein gamma | |
|
2 | 12 | ||||||
| MIRT474571 | KLHDC3 | kelch domain containing 3 | |
|
2 | 2 | ||||||
| MIRT477443 | ELOVL5 | ELOVL fatty acid elongase 5 | |
|
2 | 2 | ||||||
| MIRT480541 | BZW1 | basic leucine zipper and W2 domains 1 | |
|
2 | 12 | ||||||
| MIRT482110 | AKT3 | AKT serine/threonine kinase 3 | |
|
2 | 4 | ||||||
| MIRT485206 | PRKAR2A | protein kinase cAMP-dependent type II regulatory subunit alpha | |
|
2 | 8 | ||||||
| MIRT492318 | SETD1B | SET domain containing 1B | |
|
2 | 4 | ||||||
| MIRT497144 | TAPBP | TAP binding protein | |
|
2 | 2 | ||||||
| MIRT498976 | ORC4 | origin recognition complex subunit 4 | |
|
2 | 8 | ||||||
| MIRT499112 | SNRPB2 | small nuclear ribonucleoprotein polypeptide B2 | |
|
2 | 8 | ||||||
| MIRT499448 | ODF2L | outer dense fiber of sperm tails 2 like | |
|
2 | 8 | ||||||
| MIRT500089 | L2HGDH | L-2-hydroxyglutarate dehydrogenase | |
|
2 | 8 | ||||||
| MIRT500317 | ZNF622 | zinc finger protein 622 | |
|
2 | 8 | ||||||
| MIRT500414 | ZMAT3 | zinc finger matrin-type 3 | |
|
2 | 8 | ||||||
| MIRT500572 | USP53 | ubiquitin specific peptidase 53 | |
|
2 | 2 | ||||||
| MIRT500596 | UBN2 | ubinuclein 2 | |
|
2 | 10 | ||||||
| MIRT500797 | TLK1 | tousled like kinase 1 | |
|
2 | 8 | ||||||
| MIRT500932 | SRPR | SRP receptor alpha subunit | |
|
2 | 6 | ||||||
| MIRT500946 | SREK1 | splicing regulatory glutamic acid and lysine rich protein 1 | |
|
2 | 8 | ||||||
| MIRT501081 | SMAD7 | SMAD family member 7 | |
|
2 | 8 | ||||||
| MIRT501515 | PPTC7 | PTC7 protein phosphatase homolog | |
|
2 | 6 | ||||||
| MIRT501879 | MOB4 | MOB family member 4, phocein | |
|
2 | 8 | ||||||
| MIRT502195 | HSPE1-MOB4 | HSPE1-MOB4 readthrough | |
|
2 | 8 | ||||||
| MIRT502630 | DDX3X | DEAD-box helicase 3, X-linked | |
|
2 | 8 | ||||||
| MIRT502650 | DCTN5 | dynactin subunit 5 | |
|
2 | 8 | ||||||
| MIRT502914 | CDCA4 | cell division cycle associated 4 | |
|
2 | 8 | ||||||
| MIRT502938 | CDC37L1 | cell division cycle 37 like 1 | |
|
2 | 8 | ||||||
| MIRT502987 | CCND1 | cyclin D1 | |
|
|
|
6 | 3 | ||||
| MIRT503181 | AGO2 | argonaute 2, RISC catalytic component | |
|
2 | 6 | ||||||
| MIRT504532 | ZNF620 | zinc finger protein 620 | |
|
2 | 6 | ||||||
| MIRT504715 | DLC1 | DLC1 Rho GTPase activating protein | |
|
2 | 6 | ||||||
| MIRT504967 | ZNRF2 | zinc and ring finger 2 | |
|
2 | 2 | ||||||
| MIRT505073 | ZFHX4 | zinc finger homeobox 4 | |
|
2 | 6 | ||||||
| MIRT505109 | YTHDC1 | YTH domain containing 1 | |
|
2 | 6 | ||||||
| MIRT505342 | TMEM245 | transmembrane protein 245 | |
|
2 | 6 | ||||||
| MIRT505389 | TMEM100 | transmembrane protein 100 | |
|
2 | 2 | ||||||
| MIRT505681 | SESTD1 | SEC14 and spectrin domain containing 1 | |
|
2 | 6 | ||||||
| MIRT506162 | PLAG1 | PLAG1 zinc finger | |
|
2 | 8 | ||||||
| MIRT506185 | PHKA1 | phosphorylase kinase regulatory subunit alpha 1 | |
|
2 | 6 | ||||||
| MIRT506354 | NUP50 | nucleoporin 50 | |
|
2 | 6 | ||||||
| MIRT506480 | MYO5A | myosin VA | |
|
2 | 6 | ||||||
| MIRT506833 | KIF23 | kinesin family member 23 | |
|
2 | 6 | ||||||
| MIRT507310 | FEM1B | fem-1 homolog B | |
|
2 | 4 | ||||||
| MIRT507847 | CCNE2 | cyclin E2 | |
|
2 | 6 | ||||||
| MIRT508670 | DIABLO | diablo IAP-binding mitochondrial protein | |
|
2 | 4 | ||||||
| MIRT509137 | ZNF691 | zinc finger protein 691 | |
|
2 | 4 | ||||||
| MIRT509686 | ATAD5 | ATPase family, AAA domain containing 5 | |
|
2 | 4 | ||||||
| MIRT512205 | C1orf21 | chromosome 1 open reading frame 21 | |
|
2 | 6 | ||||||
| MIRT518087 | TRIM35 | tripartite motif containing 35 | |
|
2 | 2 | ||||||
| MIRT518990 | NNT | nicotinamide nucleotide transhydrogenase | |
|
2 | 4 | ||||||
| MIRT520964 | SPRED1 | sprouty related EVH1 domain containing 1 | |
|
2 | 2 | ||||||
| MIRT521049 | SLC2A3 | solute carrier family 2 member 3 | |
|
2 | 4 | ||||||
| MIRT521192 | SBNO1 | strawberry notch homolog 1 | |
|
2 | 6 | ||||||
| MIRT521619 | PSAT1 | phosphoserine aminotransferase 1 | |
|
2 | 6 | ||||||
| MIRT522770 | LAMTOR1 | late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 | |
|
2 | 2 | ||||||
| MIRT533754 | TMEM184B | transmembrane protein 184B | |
|
2 | 2 | ||||||
| MIRT534131 | SNTB2 | syntrophin beta 2 | |
|
2 | 4 | ||||||
| MIRT537159 | GID8 | GID complex subunit 8 homolog | |
|
2 | 2 | ||||||
| MIRT537812 | EFNB2 | ephrin B2 | |
|
2 | 4 | ||||||
| MIRT538108 | DDX6 | DEAD-box helicase 6 | |
|
2 | 2 | ||||||
| MIRT540839 | GNAT1 | G protein subunit alpha transducin 1 | |
|
2 | 4 | ||||||
| MIRT541019 | WIPI2 | WD repeat domain, phosphoinositide interacting 2 | |
|
2 | 2 | ||||||
| MIRT541145 | PISD | phosphatidylserine decarboxylase | |
|
2 | 2 | ||||||
| MIRT541387 | CDC42SE2 | CDC42 small effector 2 | |
|
2 | 2 | ||||||
| MIRT541422 | CBX4 | chromobox 4 | |
|
2 | 2 | ||||||
| MIRT543521 | PRSS21 | protease, serine 21 | |
|
2 | 2 | ||||||
| MIRT543794 | RALGAPB | Ral GTPase activating protein non-catalytic beta subunit | |
|
2 | 4 | ||||||
| MIRT543831 | GSG1 | germ cell associated 1 | |
|
2 | 2 | ||||||
| MIRT544961 | UGT2B4 | UDP glucuronosyltransferase family 2 member B4 | |
|
2 | 2 | ||||||
| MIRT545182 | MAP4K2 | mitogen-activated protein kinase kinase kinase kinase 2 | |
|
2 | 4 | ||||||
| MIRT545343 | CCDC83 | coiled-coil domain containing 83 | |
|
2 | 2 | ||||||
| MIRT545367 | LIN7C | lin-7 homolog C, crumbs cell polarity complex component | |
|
2 | 2 | ||||||
| MIRT545656 | SPARC | secreted protein acidic and cysteine rich | |
|
2 | 2 | ||||||
| MIRT545678 | DECR1 | 2,4-dienoyl-CoA reductase 1 | |
|
2 | 2 | ||||||
| MIRT545938 | ZBTB44 | zinc finger and BTB domain containing 44 | |
|
2 | 4 | ||||||
| MIRT546107 | USP48 | ubiquitin specific peptidase 48 | |
|
2 | 4 | ||||||
| MIRT546603 | SALL1 | spalt like transcription factor 1 | |
|
2 | 4 | ||||||
| MIRT546628 | RTN4 | reticulon 4 | |
|
2 | 2 | ||||||
| MIRT547321 | NPTN | neuroplastin | |
|
2 | 2 | ||||||
| MIRT547660 | KPNA3 | karyopherin subunit alpha 3 | |
|
2 | 2 | ||||||
| MIRT547994 | HCFC2 | host cell factor C2 | |
|
2 | 4 | ||||||
| MIRT548048 | GOLIM4 | golgi integral membrane protein 4 | |
|
2 | 2 | ||||||
| MIRT548098 | GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | |
|
2 | 4 | ||||||
| MIRT548721 | CRK | CRK proto-oncogene, adaptor protein | |
|
2 | 2 | ||||||
| MIRT548938 | CDK17 | cyclin dependent kinase 17 | |
|
2 | 2 | ||||||
| MIRT549071 | CACUL1 | CDK2 associated cullin domain 1 | |
|
2 | 2 | ||||||
| MIRT549272 | ASH1L | ASH1 like histone lysine methyltransferase | |
|
2 | 2 | ||||||
| MIRT549438 | ACTR2 | ARP2 actin related protein 2 homolog | |
|
2 | 2 | ||||||
| MIRT550462 | OSCAR | osteoclast associated, immunoglobulin-like receptor | |
|
2 | 4 | ||||||
| MIRT550794 | WARS2 | tryptophanyl tRNA synthetase 2, mitochondrial | |
|
2 | 2 | ||||||
| MIRT550819 | FAM229B | family with sequence similarity 229 member B | |
|
2 | 2 | ||||||
| MIRT551537 | EMB | embigin | |
|
2 | 2 | ||||||
| MIRT552031 | DNAJC10 | DnaJ heat shock protein family (Hsp40) member C10 | |
|
2 | 2 | ||||||
| MIRT552340 | ZNF704 | zinc finger protein 704 | |
|
2 | 2 | ||||||
| MIRT552444 | ZNF449 | zinc finger protein 449 | |
|
2 | 2 | ||||||
| MIRT553116 | UBR3 | ubiquitin protein ligase E3 component n-recognin 3 (putative) | |
|
2 | 2 | ||||||
| MIRT553448 | TOX4 | TOX high mobility group box family member 4 | |
|
2 | 2 | ||||||
| MIRT553725 | TBX18 | T-box 18 | |
|
2 | 2 | ||||||
| MIRT553805 | SZRD1 | SUZ RNA binding domain containing 1 | |
|
2 | 4 | ||||||
| MIRT554696 | RNF149 | ring finger protein 149 | |
|
2 | 2 | ||||||
| MIRT554831 | RECK | reversion inducing cysteine rich protein with kazal motifs | |
|
2 | 2 | ||||||
| MIRT555139 | PTPRD | protein tyrosine phosphatase, receptor type D | |
|
2 | 2 | ||||||
| MIRT555269 | PRDM4 | PR/SET domain 4 | |
|
2 | 2 | ||||||
| MIRT555312 | PPP2R5C | protein phosphatase 2 regulatory subunit B'gamma | |
|
2 | 4 | ||||||
| MIRT555558 | PLEKHA1 | pleckstrin homology domain containing A1 | |
|
2 | 2 | ||||||
| MIRT556379 | LURAP1L | leucine rich adaptor protein 1 like | |
|
2 | 2 | ||||||
| MIRT556669 | KMT2D | lysine methyltransferase 2D | |
|
2 | 4 | ||||||
| MIRT556853 | KANK1 | KN motif and ankyrin repeat domains 1 | |
|
2 | 4 | ||||||
| MIRT557476 | GPR27 | G protein-coupled receptor 27 | |
|
2 | 4 | ||||||
| MIRT558361 | DMTF1 | cyclin D binding myb like transcription factor 1 | |
|
2 | 2 | ||||||
| MIRT558385 | DHX33 | DEAH-box helicase 33 | |
|
2 | 2 | ||||||
| MIRT558502 | CYP26B1 | cytochrome P450 family 26 subfamily B member 1 | |
|
2 | 4 | ||||||
| MIRT558515 | CTDSPL | CTD small phosphatase like | |
|
2 | 4 | ||||||
| MIRT558583 | CREBL2 | cAMP responsive element binding protein like 2 | |
|
2 | 4 | ||||||
| MIRT558641 | CNNM2 | cyclin and CBS domain divalent metal cation transport mediator 2 | |
|
2 | 2 | ||||||
| MIRT558653 | CNKSR3 | CNKSR family member 3 | |
|
2 | 2 | ||||||
| MIRT558865 | CD2AP | CD2 associated protein | |
|
2 | 2 | ||||||
| MIRT558888 | CCNE1 | cyclin E1 | |
|
2 | 4 | ||||||
| MIRT559002 | CA8 | carbonic anhydrase 8 | |
|
2 | 2 | ||||||
| MIRT559149 | BTN3A3 | butyrophilin subfamily 3 member A3 | |
|
2 | 2 | ||||||
| MIRT559999 | RAB3IP | RAB3A interacting protein | |
|
2 | 2 | ||||||
| MIRT562023 | LANCL1 | LanC like 1 | |
|
2 | 2 | ||||||
| MIRT562474 | CNOT6L | CCR4-NOT transcription complex subunit 6 like | |
|
2 | 2 | ||||||
| MIRT562586 | CBX2 | chromobox 2 | |
|
2 | 2 | ||||||
| MIRT562595 | CAPZA2 | capping actin protein of muscle Z-line alpha subunit 2 | |
|
2 | 2 | ||||||
| MIRT562873 | KIAA1456 | KIAA1456 | |
|
2 | 2 | ||||||
| MIRT562989 | KIAA0408 | KIAA0408 | |
|
2 | 4 | ||||||
| MIRT563082 | SLC25A12 | solute carrier family 25 member 12 | |
|
2 | 2 | ||||||
| MIRT563499 | DLGAP3 | DLG associated protein 3 | |
|
2 | 2 | ||||||
| MIRT563892 | RAPH1 | Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 | |
|
2 | 2 | ||||||
| MIRT564328 | CCNT1 | cyclin T1 | |
|
2 | 2 | ||||||
| MIRT564945 | XKR7 | XK related 7 | |
|
2 | 2 | ||||||
| MIRT564981 | WNK3 | WNK lysine deficient protein kinase 3 | |
|
2 | 2 | ||||||
| MIRT566302 | PPM1A | protein phosphatase, Mg2+/Mn2+ dependent 1A | |
|
2 | 2 | ||||||
| MIRT566701 | MTMR3 | myotubularin related protein 3 | |
|
2 | 2 | ||||||
| MIRT566827 | MAP3K7 | mitogen-activated protein kinase kinase kinase 7 | |
|
2 | 2 | ||||||
| MIRT571236 | SCAMP4 | secretory carrier membrane protein 4 | |
|
2 | 2 | ||||||
| MIRT571424 | RIF1 | replication timing regulatory factor 1 | |
|
2 | 2 | ||||||
| MIRT571637 | SKI | SKI proto-oncogene | |
|
2 | 2 | ||||||
| MIRT571836 | NUFIP2 | NUFIP2, FMR1 interacting protein 2 | |
|
2 | 2 | ||||||
| MIRT571962 | KIF5B | kinesin family member 5B | |
|
2 | 2 | ||||||
| MIRT572104 | DYNLL2 | dynein light chain LC8-type 2 | |
|
2 | 2 | ||||||
| MIRT572183 | CDK6 | cyclin dependent kinase 6 | |
|
2 | 2 | ||||||
| MIRT572720 | RBL1 | RB transcriptional corepressor like 1 | |
|
2 | 2 | ||||||
| MIRT574589 | N4BP1 | NEDD4 binding protein 1 | |
|
2 | 2 | ||||||
| MIRT575878 | Cask | calcium/calmodulin-dependent serine protein kinase (MAGUK family) | |
|
2 | 3 | ||||||
| MIRT609979 | HERPUD2 | HERPUD family member 2 | |
|
2 | 2 | ||||||
| MIRT612932 | GPRIN3 | GPRIN family member 3 | |
|
2 | 2 | ||||||
| MIRT614327 | C1orf220 | chromosome 1 open reading frame 220 | |
|
2 | 2 | ||||||
| MIRT614694 | TRAK1 | trafficking kinesin protein 1 | |
|
2 | 2 | ||||||
| MIRT618328 | IPP | intracisternal A particle-promoted polypeptide | |
|
2 | 2 | ||||||
| MIRT618456 | ZFP30 | ZFP30 zinc finger protein | |
|
2 | 4 | ||||||
| MIRT621135 | EMC7 | ER membrane protein complex subunit 7 | |
|
2 | 4 | ||||||
| MIRT622878 | PDE12 | phosphodiesterase 12 | |
|
2 | 4 | ||||||
| MIRT631163 | CCBE1 | collagen and calcium binding EGF domains 1 | |
|
2 | 2 | ||||||
| MIRT632793 | KREMEN1 | kringle containing transmembrane protein 1 | |
|
2 | 2 | ||||||
| MIRT636731 | AFAP1 | actin filament associated protein 1 | |
|
2 | 2 | ||||||
| MIRT649297 | IRF8 | interferon regulatory factor 8 | |
|
2 | 2 | ||||||
| MIRT650955 | QPCTL | glutaminyl-peptide cyclotransferase like | |
|
2 | 2 | ||||||
| MIRT653267 | SOGA3 | SOGA family member 3 | |
|
2 | 2 | ||||||
| MIRT654665 | PSMG1 | proteasome assembly chaperone 1 | |
|
2 | 2 | ||||||
| MIRT656180 | MPRIP | myosin phosphatase Rho interacting protein | |
|
2 | 2 | ||||||
| MIRT659252 | CUL3 | cullin 3 | |
|
2 | 2 | ||||||
| MIRT663826 | NLRP12 | NLR family pyrin domain containing 12 | |
|
2 | 4 | ||||||
| MIRT676632 | CSNK1E | casein kinase 1 epsilon | |
|
2 | 2 | ||||||
| MIRT679503 | ZNF106 | zinc finger protein 106 | |
|
2 | 2 | ||||||
| MIRT680978 | DCAF17 | DDB1 and CUL4 associated factor 17 | |
|
2 | 2 | ||||||
| MIRT682272 | RS1 | retinoschisin 1 | |
|
2 | 2 | ||||||
| MIRT682421 | OLR1 | oxidized low density lipoprotein receptor 1 | |
|
2 | 2 | ||||||
| MIRT682510 | GLP2R | glucagon like peptide 2 receptor | |
|
2 | 2 | ||||||
| MIRT693926 | HNRNPA1L2 | heterogeneous nuclear ribonucleoprotein A1-like 2 | |
|
2 | 2 | ||||||
| MIRT700660 | PPP1R11 | protein phosphatase 1 regulatory inhibitor subunit 11 | |
|
2 | 2 | ||||||
| MIRT700740 | PLEKHA8 | pleckstrin homology domain containing A8 | |
|
2 | 2 | ||||||
| MIRT702871 | HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | |
|
2 | 2 | ||||||
| MIRT703192 | GPBP1 | GC-rich promoter binding protein 1 | |
|
2 | 2 | ||||||
| MIRT704453 | CSNK2A1 | casein kinase 2 alpha 1 | |
|
2 | 2 | ||||||
| MIRT704709 | CHEK1 | checkpoint kinase 1 | |
|
2 | 2 | ||||||
| MIRT706164 | CASK | calcium/calmodulin dependent serine protein kinase | |
|
2 | 3 | ||||||
| MIRT713334 | DNAJC28 | DnaJ heat shock protein family (Hsp40) member C28 | |
|
2 | 2 | ||||||
| MIRT713416 | SLC35E2B | solute carrier family 35 member E2B | |
|
2 | 2 | ||||||
| MIRT716300 | PAX1 | paired box 1 | |
|
2 | 2 | ||||||
| MIRT717394 | PTPRF | protein tyrosine phosphatase, receptor type F | |
|
2 | 2 | ||||||
| MIRT718453 | BTNL9 | butyrophilin like 9 | |
|
2 | 2 | ||||||
| MIRT718728 | VWA9 | integrator complex subunit 14 | |
|
2 | 2 | ||||||
| MIRT719029 | SHROOM3 | shroom family member 3 | |
|
2 | 2 | ||||||
| MIRT720367 | ZBTB8B | zinc finger and BTB domain containing 8B | |
|
2 | 2 | ||||||
| MIRT723120 | ZSCAN16 | zinc finger and SCAN domain containing 16 | |
|
2 | 2 | ||||||
| MIRT733741 | EGFR | epidermal growth factor receptor | |
|
|
|
4 | 0 | ||||
| MIRT734281 | HIF1A | hypoxia inducible factor 1 alpha subunit | |
|
|
3 | 0 | |||||
| MIRT735934 | EYA3 | EYA transcriptional coactivator and phosphatase 3 | |
|
|
3 | 0 | |||||
| MIRT755830 | IGF1 | insulin like growth factor 1 | 5 | 1 | ||||||||
| MIRT755831 | BCL2 | BCL2, apoptosis regulator | 4 | 1 | ||||||||
| MIRT755832 | CDK2 | cyclin dependent kinase 2 | 4 | 1 | ||||||||
| MIRT755833 | BAX | BCL2 associated X, apoptosis regulator | 4 | 1 | ||||||||
| miRNA-Drug Resistance Associations | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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