miRTarBase - #MIRT064805


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pre-miRNA Information
pre-miRNA hsa-mir-519c   
Genomic Coordinates chr19: 53686469 - 53686555
Description Homo sapiens miR-519c stem-loop
Comment The 5' arm of this precursor expresses a product related to miR-526 (previously named miR-526c here). Landgraf et al. confirm mature miRNA expression from both arms of the precursor .
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-519c-3p
Sequence 54| AAAGUGCAUCUUUUUAGAGGAU |75
Evidence Experimental
Experiments Array-cloned
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 2 19 + 53686523 29233923 MiREDiBase
A-to-I 3 19 + 53686524 29233923 MiREDiBase
A-to-I 8 19 + 53686529 29233923 MiREDiBase
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1164669230 4 dbSNP
rs764425172 8 dbSNP
rs1377433094 10 dbSNP
rs751997873 19 dbSNP
Putative Targets

miRNA Expression profile
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol ZBTB18   
Synonyms C2H2-171, MRD22, RP58, TAZ-1, ZNF238
Description zinc finger and BTB domain containing 18
Transcript NM_006352   
Other Transcripts NM_205768   
Expression
Putative miRNA Targets on ZBTB18
3'UTR of ZBTB18
(miRNA target sites are highlighted)		 
>ZBTB18|NM_006352|3'UTR
   1 TTTTATATATATATAAATAATATATATATATATACATATATATAAATAGATCTCTATATAGTTGTGGTACGGTCTAAAAG
  81 CAGTCTTGTTTCCTGGAAATAAAAAGTTGGGATATTAACTTGTTTTTGCACTTTAGAATAGCATGAGAATCTCACTAATT
 161 TAGCATTCTGATAAAAGAAACTTTAGAGCAAGTCAGAATAGAGAGGTGTTTTTCCTTTGAGGGGATAGGGGAAGTAAGCC
 241 AATAAGAACCTTTTAAACAAATCGTCCTGTCACAAAATGCTTTCATATGGCTTAATTTTGTCAACACTGCATTGTCTTTT
 321 GAGCTCTTTTTTCCCCCCCAACAAAGTTTTTTTGTTTTTTGTTTTTTTTTTTAAGTAGAAATTCCCTCCAGTTTTATTAG
 401 CCTCTTTATATGTCTCAAATTGCATGAATTTTTTCTGGCTGTTGGAAACCTGAATGCTTTTAGACCCAAATGGAAAATTT
 481 CTGAAATGCTGGATTATCTATTTTTAAACAAGCAGTTGACTTAAAACTTTCTGTGGCAACTTCTGGTTTTCTGACAGTTC
 561 CCAGTGAGAGAAATGCTGAAAGTACACTGGGATCACTGGGACACTGTCTTATGAAGGTTTGCTTGGGATGAAAAAGGATA
 641 TTGCAGCTTCAGCAGTGTTGAACTGTGTGTTTAAAAATGTGAATTACTGTTATTGTATACTGTAATTGATTACATGGGCT
 721 GGGGGGGTGTCAAAGAACTTGACAGGTTGTGTTGATGCTCTTAGTTGAGTCTTGAAAAGTAAATATTAACGCTACAGAAA
 801 TGCATGAGTTTCAATATATTTTTTGTCTTTGTTTGCATTGTATAACTTTAACGAGTGAGTTTAAAATTATTTAATTTCCT
 881 TAGAAAAATAGCACCATTTGGAAAAAAAAACTGGTGTTATGAAGAACGTAAATGCACTGTTTTTATTTTTATTTTATATA
 961 ATTTAAATTGACTTTCCCACTGTCTTTAAGTTGAAACTGTTAAGCTGAATAAAAACTTAAGCTGCAAATTGATAACTTCG
1041 CTACATAACAAGGAAAATATAAATGTTTACAAACAGCTTAAAGATTTGCATGTGCAGTGTGCATTTATAACAAACTTCTA
1121 ATTGCACAAAACCCATGCCAGCTCAGAGTTTAGGTGTACACATTTACCCAGTTGAGCGTTCTTAGAATAACTACTGCACA
1201 AGTTGACAATAGGTCGTTCTCTCTTTTTTTTTGTTTGCTCCCTTTTTCTTTTTCTCCCCTTCCTCCTTACCCTCCCTCCC
1281 TTACTCTCCCCCCCCACCACCACCCTCCACCCCCAACTCATGAAAAGATTCTATGGACTGAAAAAGCCCCAGGCTGAAAG
1361 GACTGGACTGCCTTGATTGACATGGGGAAGGGGGTTAGTAGACTATGTGGATTGCGGCAGCAGAGGCTGCAGCCTAACGT
1441 GTGGTTTTAATGACCAGCACGCAAGGCAAAAGCATTTTGCACAGTGTTTGTTTTCCTGTCTTGCACTTACAAATAAGGTC
1521 TATGGGAGTAGCATGGAAAACGTTTGCTGTTTTTCCCTTTTTTTTTTAATTGCTTTTGTTTAAAATTTGATCGCCTTAAC
1601 TACTGTAAACATAGCCTATTTTTGTGCTTAAGATACTGAATGGAAAACTCCATTGTGTGTTGCTGGACTGTTTTGGAAAT
1681 ATTTGGTTAAATGTGTGTTAATTTGGCTGTAATGGCATTTAAAGCAAACAAACAAACAAAAAAAGCTGTGAAAATGGCCT
1761 TGGAGCATTATCTTTAGTTACTTGAAGAGTTTCTAGTTTTTTTAAAATACAGTTTATGTTAAAATAATTTTTATTAATTT
1841 AGAGAAGACAATCAATGTCTGTGAGAAAACGGACTTTCTTTTGGATTTTCTTTTTGTGGTCATTGTGAGTGATTGCTTTT
1921 TCCTTTTCTTAGTTTCACATTCTTCCTTTGTTCTAAAACTTAGACTGACATCTAGCTTTGACAATCATAGTATGTTTTAT
2001 TTTCCTGAGGGGGAATAACTTATAATGCTGTTTAGTTTTGTACTATTGGTGTGTTGGTGAATTTTTAAACTGTGTGCTAA
2081 CTGCAATAAATTATATGAACTGAGAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' uaggagauuuuucuACGUGAAa 5'
                        ||||||| 
Target 5' tattaacttgttttTGCACTTt 3'
 113 - 134 140.00 -8.42
2 
miRNA  3' uaggagauuuuucuACGUGAAa 5'
                        ||||||| 
Target 5' ttgttttcctgtctTGCACTTa 3'
 1488 - 1509 140.00 -8.50
3 
miRNA  3' uagGAGAUUUUU--C---UACGUGAaa 5'
             :| |:||:|  |   |||||||  
Target 5' gtgTTATGAAGAACGTAAATGCACTgt 3'
 914 - 940 133.00 -8.30
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN28851020 15 COSMIC
COSN29527214 34 COSMIC
COSN30527935 36 COSMIC
COSN30119913 73 COSMIC
COSN15626972 130 COSMIC
COSN15626973 199 COSMIC
COSN31480259 220 COSMIC
COSN26641607 224 COSMIC
COSN26643198 303 COSMIC
COSN30127987 333 COSMIC
COSN30112245 354 COSMIC
COSN30129798 369 COSMIC
COSN27583566 373 COSMIC
COSN29025133 373 COSMIC
COSN30173544 474 COSMIC
COSN30142804 482 COSMIC
COSN31556061 602 COSMIC
COSN30530804 776 COSMIC
COSN31487514 807 COSMIC
COSN30125702 810 COSMIC
COSN17577866 820 COSMIC
COSN6450489 870 COSMIC
COSN22781609 911 COSMIC
COSN30136242 950 COSMIC
COSN30544456 984 COSMIC
COSN17076090 1021 COSMIC
COSN30121296 1028 COSMIC
COSN24298147 1055 COSMIC
COSN30540310 1093 COSMIC
COSN31596739 1102 COSMIC
COSN31592001 1112 COSMIC
COSN15626974 1233 COSMIC
COSN24298621 1239 COSMIC
COSN31597400 1271 COSMIC
COSN20842555 1280 COSMIC
COSN26481413 1288 COSMIC
COSN28696799 1295 COSMIC
COSN30119592 1312 COSMIC
COSN30116155 1313 COSMIC
COSN22207377 1376 COSMIC
COSN31590966 1408 COSMIC
COSN24132847 1496 COSMIC
COSN26957735 1539 COSMIC
COSN23012540 1558 COSMIC
COSN30141800 1593 COSMIC
COSN24294634 1596 COSMIC
COSN31482456 1622 COSMIC
COSN28241566 1624 COSMIC
COSN28821839 1670 COSMIC
COSN31534901 1684 COSMIC
COSN30127337 1745 COSMIC
COSN31543131 1804 COSMIC
COSN29968997 1813 COSMIC
COSN30114279 1832 COSMIC
COSN28250193 2004 COSMIC
COSN30125829 2073 COSMIC
COSN30134971 2080 COSMIC
COSN30113824 2105 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs751028118 4 dbSNP
rs757030500 4 dbSNP
rs754537426 5 dbSNP
rs1286045126 7 dbSNP
rs778553132 11 dbSNP
rs374525527 13 dbSNP
rs1283383178 17 dbSNP
rs112455960 20 dbSNP
rs564772339 20 dbSNP
rs747874887 20 dbSNP
rs780686374 20 dbSNP
rs1335224674 22 dbSNP
rs771903420 24 dbSNP
rs975176125 25 dbSNP
rs530527622 27 dbSNP
rs1393773715 28 dbSNP
rs1331916808 32 dbSNP
rs1401491656 32 dbSNP
rs1168840823 34 dbSNP
rs1421146862 34 dbSNP
rs572415612 34 dbSNP
rs1198191627 36 dbSNP
rs768181803 37 dbSNP
rs1471318636 38 dbSNP
rs776214706 40 dbSNP
rs953850286 47 dbSNP
rs1411704530 49 dbSNP
rs1475700116 51 dbSNP
rs1189782867 57 dbSNP
rs1440771024 61 dbSNP
rs985819588 65 dbSNP
rs1016861231 71 dbSNP
rs540045885 72 dbSNP
rs1256482203 73 dbSNP
rs1217645130 77 dbSNP
rs1444294262 115 dbSNP
rs998498504 116 dbSNP
rs1189248707 120 dbSNP
rs1285589377 126 dbSNP
rs188045468 127 dbSNP
rs972444847 133 dbSNP
rs1339344204 134 dbSNP
rs1309911421 142 dbSNP
rs1448855252 144 dbSNP
rs561551983 150 dbSNP
rs765946371 166 dbSNP
rs1405726706 173 dbSNP
rs921125095 173 dbSNP
rs939135480 174 dbSNP
rs554704783 180 dbSNP
rs953882947 185 dbSNP
rs547234645 187 dbSNP
rs761443658 192 dbSNP
rs1442022911 197 dbSNP
rs1338512653 205 dbSNP
rs1236866174 225 dbSNP
rs1380082027 227 dbSNP
rs991864533 231 dbSNP
rs916787644 243 dbSNP
rs948247251 250 dbSNP
rs1044246749 256 dbSNP
rs904116200 257 dbSNP
rs935555745 258 dbSNP
rs1207645383 259 dbSNP
rs1052469526 264 dbSNP
rs567021773 265 dbSNP
rs1374651221 271 dbSNP
rs1213258277 274 dbSNP
rs150441259 276 dbSNP
rs1332587178 287 dbSNP
rs77915082 287 dbSNP
rs1325805260 301 dbSNP
rs1403747805 302 dbSNP
rs1365048066 306 dbSNP
rs1159384828 307 dbSNP
rs920985730 318 dbSNP
rs1261710333 324 dbSNP
rs1460997765 325 dbSNP
rs192465744 327 dbSNP
rs543994510 327 dbSNP
rs1050497148 328 dbSNP
rs1036299170 329 dbSNP
rs1283540130 333 dbSNP
rs889172096 333 dbSNP
rs919356879 333 dbSNP
rs1006739060 335 dbSNP
rs1346901289 336 dbSNP
rs1017156832 337 dbSNP
rs962682394 338 dbSNP
rs569201540 339 dbSNP
rs930759147 340 dbSNP
rs538216631 344 dbSNP
rs994480404 346 dbSNP
rs1345182836 347 dbSNP
rs1186062151 348 dbSNP
rs1298993624 350 dbSNP
rs1049116717 355 dbSNP
rs1401977530 355 dbSNP
rs1159055413 359 dbSNP
rs1480312212 362 dbSNP
rs557006976 362 dbSNP
rs562378230 362 dbSNP
rs894674661 363 dbSNP
rs772542071 369 dbSNP
rs796078285 376 dbSNP
rs1046412013 387 dbSNP
rs1178275189 387 dbSNP
rs1313937298 389 dbSNP
rs1276405565 392 dbSNP
rs907412648 396 dbSNP
rs998944549 399 dbSNP
rs1031311307 402 dbSNP
rs1011353095 405 dbSNP
rs892792921 405 dbSNP
rs1468913368 409 dbSNP
rs960361240 411 dbSNP
rs1318572715 412 dbSNP
rs1448833553 415 dbSNP
rs991747681 425 dbSNP
rs916337928 428 dbSNP
rs1346667900 429 dbSNP
rs183884013 434 dbSNP
rs536095853 436 dbSNP
rs377042727 442 dbSNP
rs1346666110 446 dbSNP
rs1225904778 465 dbSNP
rs1281707157 466 dbSNP
rs1323276682 467 dbSNP
rs552758985 468 dbSNP
rs1418330962 477 dbSNP
rs925422956 489 dbSNP
rs369080519 492 dbSNP
rs1483927163 505 dbSNP
rs1206157304 507 dbSNP
rs1235709946 510 dbSNP
rs961291156 514 dbSNP
rs1458071505 521 dbSNP
rs972613050 524 dbSNP
rs572692786 537 dbSNP
rs1200771821 540 dbSNP
rs919283779 542 dbSNP
rs1295123765 554 dbSNP
rs1286591820 558 dbSNP
rs935625263 559 dbSNP
rs1445543768 562 dbSNP
rs1215118914 564 dbSNP
rs1247396351 571 dbSNP
rs762531975 572 dbSNP
rs1490479097 575 dbSNP
rs1452498553 577 dbSNP
rs1052679445 580 dbSNP
rs1460781173 588 dbSNP
rs930643210 589 dbSNP
rs1165006944 591 dbSNP
rs923304523 596 dbSNP
rs866874506 601 dbSNP
rs915963726 607 dbSNP
rs544826509 612 dbSNP
rs1239922421 618 dbSNP
rs1158992920 623 dbSNP
rs1480170473 628 dbSNP
rs188369566 630 dbSNP
rs1251018567 636 dbSNP
rs889224430 639 dbSNP
rs1323615523 641 dbSNP
rs772491509 643 dbSNP
rs1245907655 644 dbSNP
rs1006700246 645 dbSNP
rs1312054290 647 dbSNP
rs1390074303 667 dbSNP
rs1038237586 669 dbSNP
rs1459059105 679 dbSNP
rs1316974765 684 dbSNP
rs561715194 693 dbSNP
rs573684654 694 dbSNP
rs994139839 700 dbSNP
rs1176679077 710 dbSNP
rs750135496 712 dbSNP
rs1011236726 721 dbSNP
rs892844308 721 dbSNP
rs1025520258 727 dbSNP
rs1267029579 732 dbSNP
rs1221889345 738 dbSNP
rs1354475625 743 dbSNP
rs1288806477 744 dbSNP
rs1301828010 750 dbSNP
rs1237467235 757 dbSNP
rs960576256 777 dbSNP
rs1302346650 780 dbSNP
rs1388874083 781 dbSNP
rs1343327301 790 dbSNP
rs1013217001 791 dbSNP
rs766265606 792 dbSNP
rs1281691865 793 dbSNP
rs1400134397 809 dbSNP
rs755552363 815 dbSNP
rs1008493048 819 dbSNP
rs1156776419 826 dbSNP
rs1378006086 827 dbSNP
rs1223460881 828 dbSNP
rs540991871 838 dbSNP
rs979577960 843 dbSNP
rs1427517047 850 dbSNP
rs564973400 852 dbSNP
rs576235298 853 dbSNP
rs1265340766 854 dbSNP
rs759304776 861 dbSNP
rs957089038 870 dbSNP
rs1266676898 871 dbSNP
rs1257092707 885 dbSNP
rs767340999 889 dbSNP
rs2486536 892 dbSNP
rs112925657 893 dbSNP
rs1218821383 896 dbSNP
rs1341843270 900 dbSNP
rs772960227 902 dbSNP
rs972665297 902 dbSNP
rs113046403 903 dbSNP
rs1468228340 907 dbSNP
rs1157653308 909 dbSNP
rs952055503 911 dbSNP
rs1385545285 912 dbSNP
rs1374988858 914 dbSNP
rs1191203861 915 dbSNP
rs984717027 919 dbSNP
rs1202653323 921 dbSNP
rs1257544952 921 dbSNP
rs933537242 924 dbSNP
rs1050440546 928 dbSNP
rs1262841048 929 dbSNP
rs1161177187 935 dbSNP
rs1319637261 940 dbSNP
rs1365484942 940 dbSNP
rs1226117905 944 dbSNP
rs910530966 978 dbSNP
rs942164097 980 dbSNP
rs1450272614 981 dbSNP
rs1405099669 982 dbSNP
rs1331854501 983 dbSNP
rs1038191315 986 dbSNP
rs1466988195 1014 dbSNP
rs530418831 1018 dbSNP
rs76217721 1020 dbSNP
rs560704968 1021 dbSNP
rs1369092861 1029 dbSNP
rs1185971012 1033 dbSNP
rs1046849511 1037 dbSNP
rs1361944340 1038 dbSNP
rs532736019 1040 dbSNP
rs1013435408 1041 dbSNP
rs934811620 1044 dbSNP
rs1194833954 1045 dbSNP
rs552418471 1046 dbSNP
rs879426603 1054 dbSNP
rs904848700 1055 dbSNP
rs1000659553 1063 dbSNP
rs1382029688 1065 dbSNP
rs1032507661 1091 dbSNP
rs956448215 1093 dbSNP
rs1448783312 1097 dbSNP
rs866828062 1098 dbSNP
rs372719731 1100 dbSNP
rs1327142327 1104 dbSNP
rs1409537190 1109 dbSNP
rs1391564295 1113 dbSNP
rs1049378571 1114 dbSNP
rs1422822743 1118 dbSNP
rs1030488087 1136 dbSNP
rs192588978 1146 dbSNP
rs986375285 1152 dbSNP
rs910595581 1158 dbSNP
rs559418394 1159 dbSNP
rs548182329 1161 dbSNP
rs1270587723 1163 dbSNP
rs919347303 1170 dbSNP
rs1243344531 1173 dbSNP
rs1219667806 1175 dbSNP
rs897028582 1178 dbSNP
rs1313455712 1179 dbSNP
rs112497158 1182 dbSNP
rs1046901064 1188 dbSNP
rs952607538 1190 dbSNP
rs536187559 1194 dbSNP
rs1462885183 1206 dbSNP
rs1364990671 1210 dbSNP
rs1299345408 1216 dbSNP
rs113079109 1217 dbSNP
rs1406405115 1218 dbSNP
rs199884785 1218 dbSNP
rs201027584 1218 dbSNP
rs141472162 1222 dbSNP
rs1431037444 1222 dbSNP
rs928701247 1222 dbSNP
rs981587611 1222 dbSNP
rs1395038730 1223 dbSNP
rs111838953 1224 dbSNP
rs1445272602 1224 dbSNP
rs564462241 1224 dbSNP
rs572093981 1224 dbSNP
rs80343896 1224 dbSNP
rs988957178 1224 dbSNP
rs1221839774 1225 dbSNP
rs74151279 1226 dbSNP
rs1432969711 1230 dbSNP
rs200817417 1230 dbSNP
rs1337846380 1233 dbSNP
rs1385232426 1234 dbSNP
rs1450750084 1237 dbSNP
rs1314416601 1238 dbSNP
rs1327103266 1239 dbSNP
rs1229784952 1241 dbSNP
rs116488334 1244 dbSNP
rs1337417847 1249 dbSNP
rs1415425073 1250 dbSNP
rs1197757762 1255 dbSNP
rs1408708056 1258 dbSNP
rs1173820934 1266 dbSNP
rs1479873975 1269 dbSNP
rs1263556100 1270 dbSNP
rs1462347152 1271 dbSNP
rs1423882248 1276 dbSNP
rs1201391374 1278 dbSNP
rs1254793494 1280 dbSNP
rs1428579553 1282 dbSNP
rs1194781354 1284 dbSNP
rs1371812640 1286 dbSNP
rs1477807125 1287 dbSNP
rs1050414640 1288 dbSNP
rs1202779942 1288 dbSNP
rs1210673908 1288 dbSNP
rs1323175726 1288 dbSNP
rs1177535886 1289 dbSNP
rs558434683 1290 dbSNP
rs1216452940 1292 dbSNP
rs1408795136 1293 dbSNP
rs575317188 1294 dbSNP
rs1407739272 1295 dbSNP
rs189663377 1295 dbSNP
rs1446431885 1296 dbSNP
rs554612217 1296 dbSNP
rs913575643 1297 dbSNP
rs943695600 1298 dbSNP
rs965520749 1298 dbSNP
rs1383969256 1300 dbSNP
rs1293589004 1303 dbSNP
rs1305843024 1306 dbSNP
rs1324567655 1307 dbSNP
rs753456145 1309 dbSNP
rs1283612716 1310 dbSNP
rs1385711881 1311 dbSNP
rs1313521473 1313 dbSNP
rs1325442207 1314 dbSNP
rs1221521681 1315 dbSNP
rs1255045041 1316 dbSNP
rs1374454894 1317 dbSNP
rs1299562898 1318 dbSNP
rs1486012625 1319 dbSNP
rs1000946649 1321 dbSNP
rs1439492661 1322 dbSNP
rs1206358191 1324 dbSNP
rs1163739020 1328 dbSNP
rs1031983583 1330 dbSNP
rs1162788654 1331 dbSNP
rs993979432 1334 dbSNP
rs748562650 1342 dbSNP
rs1179192309 1349 dbSNP
rs1009306677 1350 dbSNP
rs1232485718 1351 dbSNP
rs1030539014 1352 dbSNP
rs1048186149 1354 dbSNP
rs1290232091 1355 dbSNP
rs954858455 1367 dbSNP
rs888266565 1368 dbSNP
rs1012187690 1371 dbSNP
rs1222395883 1373 dbSNP
rs370480862 1375 dbSNP
rs1479661441 1376 dbSNP
rs1018282895 1378 dbSNP
rs879622076 1381 dbSNP
rs970115859 1384 dbSNP
rs963637034 1385 dbSNP
rs540973799 1386 dbSNP
rs1302506754 1388 dbSNP
rs973828667 1389 dbSNP
rs1035776759 1391 dbSNP
rs919244800 1394 dbSNP
rs560745566 1395 dbSNP
rs1287150862 1396 dbSNP
rs1407601667 1404 dbSNP
rs532629166 1407 dbSNP
rs1266808131 1409 dbSNP
rs992862782 1413 dbSNP
rs1486504470 1414 dbSNP
rs914768822 1415 dbSNP
rs917788517 1416 dbSNP
rs949224452 1417 dbSNP
rs1224926497 1418 dbSNP
rs985765340 1421 dbSNP
rs1044870527 1423 dbSNP
rs943721339 1435 dbSNP
rs546391903 1439 dbSNP
rs1280196054 1440 dbSNP
rs976800792 1442 dbSNP
rs1452802584 1448 dbSNP
rs1406455917 1455 dbSNP
rs1177455193 1461 dbSNP
rs918348665 1462 dbSNP
rs1427427507 1465 dbSNP
rs1198336359 1468 dbSNP
rs138191545 1473 dbSNP
rs772952772 1475 dbSNP
rs1203836430 1484 dbSNP
rs1485764636 1509 dbSNP
rs892128610 1511 dbSNP
rs1048114285 1513 dbSNP
rs1205945016 1518 dbSNP
rs867859125 1523 dbSNP
rs1262114508 1530 dbSNP
rs1227589217 1534 dbSNP
rs1051514605 1535 dbSNP
rs1300387697 1538 dbSNP
rs1317086567 1542 dbSNP
rs530880823 1543 dbSNP
rs890176700 1546 dbSNP
rs1381533371 1548 dbSNP
rs1383280957 1555 dbSNP
rs1338508351 1556 dbSNP
rs1404261407 1558 dbSNP
rs142367529 1558 dbSNP
rs1468036782 1558 dbSNP
rs1008155658 1561 dbSNP
rs1462567541 1563 dbSNP
rs548867956 1564 dbSNP
rs181883883 1568 dbSNP
rs995084680 1569 dbSNP
rs1222677239 1570 dbSNP
rs1271648148 1573 dbSNP
rs1490017836 1574 dbSNP
rs1244258101 1577 dbSNP
rs1002890999 1594 dbSNP
rs1026764840 1604 dbSNP
rs1242157928 1605 dbSNP
rs1195949103 1619 dbSNP
rs1340896512 1631 dbSNP
rs1249058059 1634 dbSNP
rs1251732032 1635 dbSNP
rs1421038529 1639 dbSNP
rs1360164791 1654 dbSNP
rs1317063713 1655 dbSNP
rs1157213831 1659 dbSNP
rs1035724777 1667 dbSNP
rs891785157 1684 dbSNP
rs1333794606 1685 dbSNP
rs1379981908 1698 dbSNP
rs1392132703 1705 dbSNP
rs1425373640 1706 dbSNP
rs950717139 1710 dbSNP
rs992749239 1714 dbSNP
rs1010366327 1725 dbSNP
rs202153295 1725 dbSNP
rs968923106 1729 dbSNP
rs1367344491 1730 dbSNP
rs917338805 1731 dbSNP
rs1434238988 1734 dbSNP
rs1292687827 1735 dbSNP
rs1018547171 1738 dbSNP
rs185811018 1738 dbSNP
rs985992888 1738 dbSNP
rs970085992 1742 dbSNP
rs1247978883 1745 dbSNP
rs1203894843 1746 dbSNP
rs965984848 1761 dbSNP
rs778949959 1763 dbSNP
rs981037702 1769 dbSNP
rs189435496 1773 dbSNP
rs1358494500 1782 dbSNP
rs1279974400 1784 dbSNP
rs926465847 1787 dbSNP
rs1337824760 1792 dbSNP
rs936618697 1796 dbSNP
rs1409299848 1797 dbSNP
rs747872246 1807 dbSNP
rs1373790262 1808 dbSNP
rs1053706904 1813 dbSNP
rs1305518132 1828 dbSNP
rs1423232201 1831 dbSNP
rs765837609 1849 dbSNP
rs1304390629 1851 dbSNP
rs1159580393 1857 dbSNP
rs1471356324 1864 dbSNP
rs568163000 1871 dbSNP
rs527660466 1872 dbSNP
rs1293350384 1877 dbSNP
rs181953360 1879 dbSNP
rs1221484181 1887 dbSNP
rs945034957 1892 dbSNP
rs1451007531 1897 dbSNP
rs1481816578 1900 dbSNP
rs1284863636 1901 dbSNP
rs1175915620 1904 dbSNP
rs1206734319 1905 dbSNP
rs1348202847 1910 dbSNP
rs909599863 1911 dbSNP
rs947913083 1914 dbSNP
rs1051401391 1916 dbSNP
rs3210202 1918 dbSNP
rs890229528 1925 dbSNP
rs1445519780 1943 dbSNP
rs1045276240 1944 dbSNP
rs1185440997 1947 dbSNP
rs1403144315 1951 dbSNP
rs1349873133 1952 dbSNP
rs142796285 1956 dbSNP
rs538530248 1962 dbSNP
rs1403468710 1973 dbSNP
rs1402815379 1975 dbSNP
rs1383213179 1977 dbSNP
rs939291367 1978 dbSNP
rs1480587597 1983 dbSNP
rs1430937352 1984 dbSNP
rs1477400727 2003 dbSNP
rs1242644378 2006 dbSNP
rs1195156815 2009 dbSNP
rs1164005723 2013 dbSNP
rs1267202845 2016 dbSNP
rs774241187 2024 dbSNP
rs759537637 2046 dbSNP
rs1324583836 2048 dbSNP
rs899321795 2057 dbSNP
rs767285921 2066 dbSNP
rs1265222630 2071 dbSNP
rs1217564291 2073 dbSNP
rs1355097691 2074 dbSNP
rs1463307511 2084 dbSNP
rs891838344 2092 dbSNP
rs1433445731 2093 dbSNP
rs1010208736 2094 dbSNP
rs1329113902 2095 dbSNP
rs1325179344 2098 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM545213. RNA binding protein: AGO2. Condition:Control ...

- Hafner M; Landthaler M; Burger L; Khorshid et al., 2010, Cell.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' uaggagauuuuucuACGUGAAa 5'
                        ||||||| 
Target 5' ---uuuuccugucuUGCACUUa 3'
 		1 - 19
Article - Hafner M; Landthaler M; Burger L; Khorshid et al.
- Cell, 2010
RNA transcripts are subject to posttranscriptional gene regulation involving hundreds of RNA-binding proteins (RBPs) and microRNA-containing ribonucleoprotein complexes (miRNPs) expressed in a cell-type dependent fashion. We developed a cell-based crosslinking approach to determine at high resolution and transcriptome-wide the binding sites of cellular RBPs and miRNPs. The crosslinked sites are revealed by thymidine to cytidine transitions in the cDNAs prepared from immunopurified RNPs of 4-thiouridine-treated cells. We determined the binding sites and regulatory consequences for several intensely studied RBPs and miRNPs, including PUM2, QKI, IGF2BP1-3, AGO/EIF2C1-4 and TNRC6A-C. Our study revealed that these factors bind thousands of sites containing defined sequence motifs and have distinct preferences for exonic versus intronic or coding versus untranslated transcript regions. The precise mapping of binding sites across the transcriptome will be critical to the interpretation of the rapidly emerging data on genetic variation between individuals and how these variations contribute to complex genetic diseases.
LinkOut: [PMID: 20371350]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Disease 10472.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM714644. RNA binding protein: AGO2. Condition:completeT1 ...

- Kishore S; Jaskiewicz L; Burger L; Hausser et al., 2011, Nature methods.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' uaggagauuuuucuACGUGAAa 5'
                        ||||||| 
Target 5' uauuaacuuguuuuUGCACUUu 3'
 		17 - 38
Article - Kishore S; Jaskiewicz L; Burger L; Hausser et al.
- Nature methods, 2011
Cross-linking and immunoprecipitation (CLIP) is increasingly used to map transcriptome-wide binding sites of RNA-binding proteins. We developed a method for CLIP data analysis, and applied it to compare CLIP with photoactivatable ribonucleoside-enhanced CLIP (PAR-CLIP) and to uncover how differences in cross-linking and ribonuclease digestion affect the identified sites. We found only small differences in accuracies of these methods in identifying binding sites of HuR, which binds low-complexity sequences, and Argonaute 2, which has a complex binding specificity. We found that cross-link-induced mutations led to single-nucleotide resolution for both PAR-CLIP and CLIP. Our results confirm the expectation from original CLIP publications that RNA-binding proteins do not protect their binding sites sufficiently under the denaturing conditions used during the CLIP procedure, and we show that extensive digestion with sequence-specific RNases strongly biases the recovered binding sites. This bias can be substantially reduced by milder nuclease digestion conditions.
LinkOut: [PMID: 21572407]
CLIP-seq Support 1 for dataset GSM545213
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / Control
Location of target site ENST00000358704.4 | 3UTR | UUUUCCUGUCUUGCACUUA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 20371350 / GSE21578
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM714644
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / completeT1, repA
Location of target site ENST00000358704.4 | 3UTR | AAAUAAAAAGUUGGGAUAUUAACUUGUUUUUGCACUUUAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 21572407 / GSE28865
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
325 hsa-miR-519c-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT000496 HIF1A hypoxia inducible factor 1 alpha subunit 4 1
MIRT000998 ABCG2 ATP binding cassette subfamily G member 2 (Junior blood group) 4 3
MIRT003732 ELAVL1 ELAV like RNA binding protein 1 3 1
MIRT006639 TIMP2 TIMP metallopeptidase inhibitor 2 3 1
MIRT006640 PTEN phosphatase and tensin homolog 3 1
MIRT006641 CDKN1A cyclin dependent kinase inhibitor 1A 3 1
MIRT055028 TPRG1L tumor protein p63 regulated 1 like 2 2
MIRT055393 SHOC2 SHOC2, leucine rich repeat scaffold protein 2 6
MIRT056828 REEP3 receptor accessory protein 3 2 2
MIRT060504 PPP6R3 protein phosphatase 6 regulatory subunit 3 2 2
MIRT061796 PPP1R15B protein phosphatase 1 regulatory subunit 15B 2 10
MIRT063354 ETNK1 ethanolamine kinase 1 2 2
MIRT064424 ARID4B AT-rich interaction domain 4B 2 2
MIRT064719 CCND2 cyclin D2 2 2
MIRT064805 ZBTB18 zinc finger and BTB domain containing 18 2 4
MIRT065609 DAZAP2 DAZ associated protein 2 2 10
MIRT065622 CLIC4 chloride intracellular channel 4 2 4
MIRT065872 GDF11 growth differentiation factor 11 2 2
MIRT065892 RAB5B RAB5B, member RAS oncogene family 2 8
MIRT068751 RB1 RB transcriptional corepressor 1 2 2
MIRT070050 FANCM Fanconi anemia complementation group M 2 2
MIRT071004 SMOC1 SPARC related modular calcium binding 1 2 2
MIRT071334 CMPK1 cytidine/uridine monophosphate kinase 1 2 6
MIRT071912 ZFYVE9 zinc finger FYVE-type containing 9 2 2
MIRT072732 GLCE glucuronic acid epimerase 2 2
MIRT076028 COX10 COX10, heme A:farnesyltransferase cytochrome c oxidase assembly factor 2 6
MIRT076046 PITPNA phosphatidylinositol transfer protein alpha 2 2
MIRT079353 CCDC137 coiled-coil domain containing 137 2 2
MIRT080227 SMAD4 SMAD family member 4 2 6
MIRT081122 LDLR low density lipoprotein receptor 2 8
MIRT081205 MIDN midnolin 2 10
MIRT085098 IFNAR2 interferon alpha and beta receptor subunit 2 2 6
MIRT085149 SLC5A3 solute carrier family 5 member 3 2 4
MIRT086436 NABP1 nucleic acid binding protein 1 2 6
MIRT088037 UBXN2A UBX domain protein 2A 2 2
MIRT088132 SEPT2 septin 2 2 4
MIRT088343 MAPRE3 microtubule associated protein RP/EB family member 3 2 8
MIRT090645 U2SURP U2 snRNP associated SURP domain containing 2 6
MIRT090805 MBNL1 muscleblind like splicing regulator 1 2 4
MIRT091692 TGFBR2 transforming growth factor beta receptor 2 2 4
MIRT092689 C3ORF38 chromosome 3 open reading frame 38 2 8
MIRT093954 SLAIN2 SLAIN motif family member 2 2 2
MIRT095727 ANKH ANKH inorganic pyrophosphate transport regulator 2 8
MIRT097158 FCHO2 FCH domain only 2 2 2
MIRT099319 QKI QKI, KH domain containing RNA binding 2 4
MIRT099835 SOX4 SRY-box 4 2 10
MIRT100773 ENPP4 ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative) 2 2
MIRT100955 CENPQ centromere protein Q 2 4
MIRT102229 HBP1 HMG-box transcription factor 1 2 2
MIRT102299 DNAJB9 DnaJ heat shock protein family (Hsp40) member B9 2 10
MIRT102621 UBN2 ubinuclein 2 2 8
MIRT103780 PURB purine rich element binding protein B 2 2
MIRT104168 PHTF2 putative homeodomain transcription factor 2 2 6
MIRT107279 FAM73B mitoguardin 2 2 2
MIRT107945 TMEM2 transmembrane protein 2 2 2
MIRT108265 HABP4 hyaluronan binding protein 4 2 2
MIRT124812 BICD2 BICD cargo adaptor 2 2 2
MIRT138707 MPP5 membrane palmitoylated protein 5 2 2
MIRT139880 BTF3L4 basic transcription factor 3 like 4 2 6
MIRT144312 NFAT5 nuclear factor of activated T-cells 5 2 8
MIRT145605 LASP1 LIM and SH3 protein 1 2 2
MIRT153350 MAVS mitochondrial antiviral signaling protein 2 4
MIRT153986 PRNP prion protein 2 2
MIRT159129 NRBP1 nuclear receptor binding protein 1 2 2
MIRT164533 MSMO1 methylsterol monooxygenase 1 2 2
MIRT165912 CREBRF CREB3 regulatory factor 2 2
MIRT170858 TAX1BP1 Tax1 binding protein 1 2 4
MIRT172157 FZD6 frizzled class receptor 6 2 8
MIRT173701 PRPF4 pre-mRNA processing factor 4 2 2
MIRT175003 ZBTB5 zinc finger and BTB domain containing 5 2 4
MIRT175400 ACSL4 acyl-CoA synthetase long chain family member 4 2 2
MIRT178069 SAMD8 sterile alpha motif domain containing 8 2 2
MIRT178675 FAM102B family with sequence similarity 102 member B 2 2
MIRT180847 RPRD2 regulation of nuclear pre-mRNA domain containing 2 2 4
MIRT194911 RBBP6 RB binding protein 6, ubiquitin ligase 2 8
MIRT195755 ATMIN ATM interactor 2 6
MIRT196623 TAOK1 TAO kinase 1 2 6
MIRT205286 STK11IP serine/threonine kinase 11 interacting protein 2 2
MIRT206051 PPARA peroxisome proliferator activated receptor alpha 2 2
MIRT206198 RAB10 RAB10, member RAS oncogene family 2 4
MIRT208980 SKIL SKI like proto-oncogene 2 10
MIRT223637 ATP6V1C1 ATPase H+ transporting V1 subunit C1 2 4
MIRT224757 DPYSL2 dihydropyrimidinase like 2 2 2
MIRT227995 NFIB nuclear factor I B 2 4
MIRT230973 PRRG4 proline rich and Gla domain 4 2 2
MIRT238183 ANKRD33B ankyrin repeat domain 33B 2 10
MIRT242425 HAS3 hyaluronan synthase 3 2 2
MIRT242666 SALL3 spalt like transcription factor 3 2 4
MIRT242765 FNBP1L formin binding protein 1 like 2 6
MIRT243095 LCLAT1 lysocardiolipin acyltransferase 1 2 4
MIRT243437 PAK2 p21 (RAC1) activated kinase 2 2 2
MIRT243964 MAP1B microtubule associated protein 1B 2 2
MIRT244776 RABGAP1 RAB GTPase activating protein 1 2 2
MIRT246630 TMEM109 transmembrane protein 109 2 2
MIRT246968 TSKU tsukushi, small leucine rich proteoglycan 2 2
MIRT266055 FJX1 four jointed box 1 2 4
MIRT266858 SLC25A44 solute carrier family 25 member 44 2 2
MIRT283184 C16ORF52 chromosome 16 open reading frame 52 2 2
MIRT286955 SOCS7 suppressor of cytokine signaling 7 2 2
MIRT293651 PVR poliovirus receptor 2 4
MIRT295178 ZNF317 zinc finger protein 317 2 4
MIRT302453 CLIP4 CAP-Gly domain containing linker protein family member 4 2 2
MIRT303499 NAGK N-acetylglucosamine kinase 2 6
MIRT368755 CDADC1 cytidine and dCMP deaminase domain containing 1 2 2
MIRT383207 APH1A aph-1 homolog A, gamma-secretase subunit 2 2
MIRT383610 POU2F1 POU class 2 homeobox 1 2 2
MIRT396102 CASP2 caspase 2 2 2
MIRT441419 FAM9C family with sequence similarity 9 member C 2 2
MIRT446818 C5orf30 chromosome 5 open reading frame 30 2 2
MIRT448307 WNK3 WNK lysine deficient protein kinase 3 2 2
MIRT461781 MPDU1 mannose-P-dolichol utilization defect 1 2 2
MIRT462816 NTN1 netrin 1 2 2
MIRT463613 ZBTB34 zinc finger and BTB domain containing 34 2 2
MIRT464560 UBTF upstream binding transcription factor, RNA polymerase I 2 2
MIRT464842 RPS27A ribosomal protein S27a 2 12
MIRT465225 TRIP10 thyroid hormone receptor interactor 10 2 2
MIRT466446 TFAM transcription factor A, mitochondrial 2 8
MIRT466836 STX6 syntaxin 6 2 6
MIRT467185 SPTY2D1 SPT2 chromatin protein domain containing 1 2 2
MIRT468179 SGMS1 sphingomyelin synthase 1 2 2
MIRT469850 PXK PX domain containing serine/threonine kinase like 2 8
MIRT471612 PAQR5 progestin and adipoQ receptor family member 5 2 19
MIRT472008 NR1D2 nuclear receptor subfamily 1 group D member 2 2 2
MIRT472159 NIN ninein 2 4
MIRT472336 NETO2 neuropilin and tolloid like 2 2 4
MIRT473162 MLLT1 MLLT1, super elongation complex subunit 2 2
MIRT473623 MARK2 microtubule affinity regulating kinase 2 2 2
MIRT473682 MAPKBP1 mitogen-activated protein kinase binding protein 1 2 2
MIRT473805 MAP3K2 mitogen-activated protein kinase kinase kinase 2 2 2
MIRT474416 KLHL28 kelch like family member 28 2 8
MIRT474736 KIF13A kinesin family member 13A 2 6
MIRT474966 KCTD10 potassium channel tetramerization domain containing 10 2 4
MIRT475464 HSPA8 heat shock protein family A (Hsp70) member 8 2 6
MIRT476120 GPR157 G protein-coupled receptor 157 2 2
MIRT476203 GNS glucosamine (N-acetyl)-6-sulfatase 2 6
MIRT477180 F3 coagulation factor III, tissue factor 2 8
MIRT478103 DLG5 discs large MAGUK scaffold protein 5 2 6
MIRT478713 CSNK1A1 casein kinase 1 alpha 1 2 6
MIRT479055 CNOT6L CCR4-NOT transcription complex subunit 6 like 2 8
MIRT480008 CAPRIN2 caprin family member 2 2 4
MIRT480519 C11orf30 EMSY, BRCA2 interacting transcriptional repressor 2 10
MIRT480822 BLCAP bladder cancer associated protein 2 10
MIRT480944 BBX BBX, HMG-box containing 2 8
MIRT481336 ATL3 atlastin GTPase 3 2 2
MIRT481598 ARHGAP1 Rho GTPase activating protein 1 2 6
MIRT481877 ANKRD50 ankyrin repeat domain 50 2 2
MIRT482471 ADAR adenosine deaminase, RNA specific 2 4
MIRT484875 ZNF652 zinc finger protein 652 2 2
MIRT485090 SLC30A1 solute carrier family 30 member 1 2 4
MIRT485579 FOXQ1 forkhead box Q1 2 2
MIRT485618 FBXL5 F-box and leucine rich repeat protein 5 2 10
MIRT486751 CNOT4 CCR4-NOT transcription complex subunit 4 2 6
MIRT489599 ZDHHC20 zinc finger DHHC-type containing 20 2 10
MIRT489889 MPLKIP M-phase specific PLK1 interacting protein 2 2
MIRT491654 PDRG1 p53 and DNA damage regulated 1 2 10
MIRT492038 TSG101 tumor susceptibility 101 2 4
MIRT492361 SEMA7A semaphorin 7A (John Milton Hagen blood group) 2 2
MIRT492776 PDGFB platelet derived growth factor subunit B 2 2
MIRT493336 LAPTM4A lysosomal protein transmembrane 4 alpha 2 12
MIRT493611 HMGB3 high mobility group box 3 2 6
MIRT497468 DDR2 discoidin domain receptor tyrosine kinase 2 2 2
MIRT498059 SNX5 sorting nexin 5 2 6
MIRT499901 KIAA1191 KIAA1191 2 4
MIRT500489 ZBTB4 zinc finger and BTB domain containing 4 2 6
MIRT500685 TRIM37 tripartite motif containing 37 2 2
MIRT500760 TMEM127 transmembrane protein 127 2 6
MIRT501456 PTPN4 protein tyrosine phosphatase, non-receptor type 4 2 8
MIRT501559 POC1B-GALNT4 POC1B-GALNT4 readthrough 2 2
MIRT501983 MAPK1 mitogen-activated protein kinase 1 2 10
MIRT502000 MAP7 microtubule associated protein 7 2 8
MIRT502049 LAMTOR1 late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 2 6
MIRT502423 GALNT4 polypeptide N-acetylgalactosaminyltransferase 4 2 2
MIRT503044 CAMSAP2 calmodulin regulated spectrin associated protein family member 2 2 2
MIRT503821 TMEM242 transmembrane protein 242 2 4
MIRT504290 PARP1 poly(ADP-ribose) polymerase 1 2 6
MIRT504560 ZNF417 zinc finger protein 417 2 6
MIRT505054 ZNF202 zinc finger protein 202 2 6
MIRT505486 SRSF2 serine and arginine rich splicing factor 2 2 4
MIRT505836 POLR1B RNA polymerase I subunit B 2 4
MIRT506372 NUFIP2 NUFIP2, FMR1 interacting protein 2 2 4
MIRT506451 NACC2 NACC family member 2 2 4
MIRT506673 LZIC leucine zipper and CTNNBIP1 domain containing 2 4
MIRT506834 KIF23 kinesin family member 23 2 4
MIRT506880 KIAA0101 PCNA clamp associated factor 2 6
MIRT507359 FAM129A family with sequence similarity 129 member A 2 6
MIRT507957 BNIP2 BCL2 interacting protein 2 2 6
MIRT509433 MCM7 minichromosome maintenance complex component 7 2 6
MIRT510872 RAN RAN, member RAS oncogene family 2 8
MIRT511078 NIPA1 non imprinted in Prader-Willi/Angelman syndrome 1 2 4
MIRT511254 KLHL36 kelch like family member 36 2 6
MIRT513699 RBM20 RNA binding motif protein 20 2 4
MIRT513742 PKNOX1 PBX/knotted 1 homeobox 1 2 2
MIRT513981 CEP97 centrosomal protein 97 2 2
MIRT514092 EPS15L1 epidermal growth factor receptor pathway substrate 15 like 1 2 6
MIRT515928 MFAP2 microfibril associated protein 2 2 4
MIRT519574 ZNFX1 zinc finger NFX1-type containing 1 2 4
MIRT521297 RRAGD Ras related GTP binding D 2 4
MIRT521348 RPP14 ribonuclease P/MRP subunit p14 2 2
MIRT521693 PRKAA1 protein kinase AMP-activated catalytic subunit alpha 1 2 8
MIRT521778 PPIG peptidylprolyl isomerase G 2 8
MIRT522191 NR2C2 nuclear receptor subfamily 2 group C member 2 2 6
MIRT524696 BTG3 BTG anti-proliferation factor 3 2 8
MIRT525663 NHSL2 NHS like 2 2 2
MIRT527252 TMEM196 transmembrane protein 196 2 2
MIRT527466 CLEC12B C-type lectin domain family 12 member B 2 2
MIRT529535 ICMT isoprenylcysteine carboxyl methyltransferase 2 2
MIRT530146 HADHB hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit 2 2
MIRT530851 RAG1 recombination activating 1 2 4
MIRT531109 PEX13 peroxisomal biogenesis factor 13 2 2
MIRT534263 SLC12A7 solute carrier family 12 member 7 2 2
MIRT534756 RASGEF1A RasGEF domain family member 1A 2 2
MIRT535175 PLEKHB2 pleckstrin homology domain containing B2 2 2
MIRT535246 PIGA phosphatidylinositol glycan anchor biosynthesis class A 2 4
MIRT535401 PER1 period circadian clock 1 2 2
MIRT536036 MCUR1 mitochondrial calcium uniporter regulator 1 2 2
MIRT536347 LEFTY1 left-right determination factor 1 2 2
MIRT536413 KREMEN1 kringle containing transmembrane protein 1 2 2
MIRT536437 KMT2B lysine methyltransferase 2B 2 6
MIRT536604 IRF2 interferon regulatory factor 2 2 2
MIRT536642 INO80D INO80 complex subunit D 2 2
MIRT536860 HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 2 2
MIRT537241 GALNT3 polypeptide N-acetylgalactosaminyltransferase 3 2 2
MIRT537728 ELAVL2 ELAV like RNA binding protein 2 2 2
MIRT537988 DPP8 dipeptidyl peptidase 8 2 2
MIRT538037 DNAJB6 DnaJ heat shock protein family (Hsp40) member B6 2 2
MIRT538255 CUL3 cullin 3 2 4
MIRT538525 CLCN3 chloride voltage-gated channel 3 2 2
MIRT538659 CCSAP centriole, cilia and spindle associated protein 2 2
MIRT538779 C7orf60 base methyltransferase of 25S rRNA 2 homolog 2 4
MIRT538849 BTG1 BTG anti-proliferation factor 1 2 2
MIRT538923 BRI3BP BRI3 binding protein 2 6
MIRT539114 ARL10 ADP ribosylation factor like GTPase 10 2 2
MIRT539454 ADARB2 adenosine deaminase, RNA specific B2 (inactive) 2 2
MIRT541085 RLIM ring finger protein, LIM domain interacting 2 2
MIRT543117 SKA2 spindle and kinetochore associated complex subunit 2 2 2
MIRT543181 FICD FIC domain containing 2 2
MIRT543575 RPF2 ribosome production factor 2 homolog 2 4
MIRT544113 IPMK inositol polyphosphate multikinase 2 2
MIRT544625 CSDE1 cold shock domain containing E1 2 2
MIRT544699 ZNF224 zinc finger protein 224 2 4
MIRT544992 MFF mitochondrial fission factor 2 4
MIRT546248 TNFRSF21 TNF receptor superfamily member 21 2 2
MIRT546282 TMEM30A transmembrane protein 30A 2 4
MIRT546290 TMEM200C transmembrane protein 200C 2 4
MIRT546558 SATB2 SATB homeobox 2 2 2
MIRT546815 RAP2C RAP2C, member of RAS oncogene family 2 2
MIRT547046 POGZ pogo transposable element derived with ZNF domain 2 2
MIRT547474 MBNL3 muscleblind like splicing regulator 3 2 4
MIRT547761 KATNAL1 katanin catalytic subunit A1 like 1 2 2
MIRT547892 HSPA13 heat shock protein family A (Hsp70) member 13 2 2
MIRT548315 EPHA4 EPH receptor A4 2 2
MIRT548383 ENPP5 ectonucleotide pyrophosphatase/phosphodiesterase 5 (putative) 2 4
MIRT548460 EGLN3 egl-9 family hypoxia inducible factor 3 2 2
MIRT548579 DNAJB14 DnaJ heat shock protein family (Hsp40) member B14 2 2
MIRT548858 CERCAM cerebral endothelial cell adhesion molecule 2 2
MIRT548896 CHEK2 checkpoint kinase 2 2 4
MIRT549319 ARHGAP12 Rho GTPase activating protein 12 2 4
MIRT550302 ZNF681 zinc finger protein 681 2 2
MIRT551120 ZNF107 zinc finger protein 107 2 2
MIRT551406 DCTPP1 dCTP pyrophosphatase 1 2 2
MIRT552173 DAD1 defender against cell death 1 2 2
MIRT552856 WIPF2 WAS/WASL interacting protein family member 2 2 2
MIRT552892 WASL Wiskott-Aldrich syndrome like 2 4
MIRT553075 UEVLD UEV and lactate/malate dehyrogenase domains 2 2
MIRT553668 TFAP4 transcription factor AP-4 2 4
MIRT553700 TCF7L2 transcription factor 7 like 2 2 2
MIRT554608 RPS6KA5 ribosomal protein S6 kinase A5 2 2
MIRT554860 RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis) 2 2
MIRT556157 MECP2 methyl-CpG binding protein 2 2 2
MIRT556179 MCC mutated in colorectal cancers 2 2
MIRT556529 LIN52 lin-52 DREAM MuvB core complex component 2 2
MIRT556723 KLHL21 kelch like family member 21 2 4
MIRT557054 HOXB3 homeobox B3 2 2
MIRT557587 GNPTAB N-acetylglucosamine-1-phosphate transferase alpha and beta subunits 2 2
MIRT557661 GATA6 GATA binding protein 6 2 2
MIRT557753 FRS2 fibroblast growth factor receptor substrate 2 2 2
MIRT557881 FEM1B fem-1 homolog B 2 4
MIRT558215 EFCAB14 EF-hand calcium binding domain 14 2 4
MIRT558264 DYNC1LI2 dynein cytoplasmic 1 light intermediate chain 2 2 2
MIRT558327 DNAJC28 DnaJ heat shock protein family (Hsp40) member C28 2 4
MIRT558766 CFL2 cofilin 2 2 2
MIRT561037 ASB6 ankyrin repeat and SOCS box containing 6 2 2
MIRT561324 ZBTB37 zinc finger and BTB domain containing 37 2 2
MIRT561641 RUNX3 runt related transcription factor 3 2 2
MIRT562555 CCDC71L coiled-coil domain containing 71 like 2 4
MIRT562961 LRPAP1 LDL receptor related protein associated protein 1 2 2
MIRT564680 ZNF35 zinc finger protein 35 2 2
MIRT565694 SESN3 sestrin 3 2 2
MIRT565910 SCAMP2 secretory carrier membrane protein 2 2 2
MIRT566141 RACGAP1 Rac GTPase activating protein 1 2 2
MIRT567047 KCNB1 potassium voltage-gated channel subfamily B member 1 2 2
MIRT567076 KBTBD2 kelch repeat and BTB domain containing 2 2 2
MIRT567539 FGFR1OP FGFR1 oncogene partner 2 2
MIRT567624 FAM210A family with sequence similarity 210 member A 2 2
MIRT570321 ZNF70 zinc finger protein 70 2 2
MIRT571759 PSD3 pleckstrin and Sec7 domain containing 3 2 2
MIRT571857 NKIRAS1 NFKB inhibitor interacting Ras like 1 2 2
MIRT573372 LIMA1 LIM domain and actin binding 1 2 2
MIRT574561 NR2F2 nuclear receptor subfamily 2 group F member 2 2 2
MIRT614729 ATAT1 alpha tubulin acetyltransferase 1 2 4
MIRT617877 ESR1 estrogen receptor 1 2 2
MIRT624421 CBX8 chromobox 8 2 2
MIRT625865 SLC35C2 solute carrier family 35 member C2 2 2
MIRT630703 DICER1 dicer 1, ribonuclease III 2 4
MIRT632514 PTPN9 protein tyrosine phosphatase, non-receptor type 9 2 2
MIRT641797 USP32 ubiquitin specific peptidase 32 2 2
MIRT663625 SEC23B Sec23 homolog B, coat complex II component 2 2
MIRT680135 ADRBK2 G protein-coupled receptor kinase 3 2 2
MIRT702388 KLF10 Kruppel like factor 10 2 2
MIRT707830 TMEM133 transmembrane protein 133 2 2
MIRT708885 MOCS2 molybdenum cofactor synthesis 2 2 2
MIRT709122 C3orf18 chromosome 3 open reading frame 18 2 2
MIRT709635 KBTBD6 kelch repeat and BTB domain containing 6 2 2
MIRT710596 CDCA4 cell division cycle associated 4 2 2
MIRT710802 IFNLR1 interferon lambda receptor 1 2 2
MIRT711782 RFXAP regulatory factor X associated protein 2 2
MIRT713344 KLRD1 killer cell lectin like receptor D1 2 2
MIRT713640 MED8 mediator complex subunit 8 2 2
MIRT713916 IGF2R insulin like growth factor 2 receptor 2 2
MIRT715068 TMTC1 transmembrane and tetratricopeptide repeat containing 1 2 2
MIRT715206 FKTN fukutin 2 2
MIRT717819 FAM114A1 family with sequence similarity 114 member A1 2 2
MIRT720543 CHERP calcium homeostasis endoplasmic reticulum protein 2 2
MIRT720636 ELF5 E74 like ETS transcription factor 5 2 2
MIRT721703 ISY1 ISY1 splicing factor homolog 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-519c Bilobalide NULL 73581 Quantitative real-time PCR Human breast cancer MCF-7 cells 21796641 2011 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-519c Docetaxel+Cisplatin+5-Fluorouracil resistant tissue (hypopharyngeal squamous cell carcinoma)
hsa-miR-519c-3p Mitoxantrone 4212 NSC279836 approved sensitive Low Breast Cancer cell line (MCF-7)
hsa-miR-519c-3p Cisplatin 5460033 NSC119875 approved resistant High Germ Cell Tumor cell line (NTERA-2)
hsa-miR-519c-3p Vinorelbine 44424639 approved resistant High Non-Small Cell Lung Cancer cell line (H358, H1993)
hsa-miR-519c-3p Tamoxifen 2733525 NSC180973 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-519c-3p Gemcitabine 60750 NSC613327 approved sensitive Low Pancreatic Cancer cell line (MIA-PaCa-2)
hsa-miR-519c-3p Osimertinib 71496458 NSC779217 approved resistant cell line (PC9)
hsa-miR-519c-3p Vemurafenib 42611257 NSC761431 approved resistant cell line (451Lu)
hsa-miR-519c-3p Vemurafenib 42611257 NSC761431 approved resistant cell line (LM36)
hsa-miR-519c-3p Fluorouracil 3385 NSC19893 approved resistant cell line (KM12C) (72 h)
hsa-miR-519c-3p Sunitinib 5329102 NSC750690 approved resistant tissue (CardA)
hsa-miR-519c-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)

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