miRTarBase - #MIRT064889


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pre-miRNA Information
pre-miRNA hsa-mir-4524b   
Genomic Coordinates chr17: 69099542 - 69099656
Description Homo sapiens miR-4524b stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4524b-3p
Sequence 66| GAGACAGGUUCAUGCUGCUA |85
Evidence Experimental
Experiments SOLiD
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1263495678 1 dbSNP
rs1350790266 9 dbSNP
rs1322445998 14 dbSNP
Putative Targets

Gene Information
Gene Symbol ZBTB18   
Synonyms C2H2-171, MRD22, RP58, TAZ-1, ZNF238
Description zinc finger and BTB domain containing 18
Transcript NM_006352   
Other Transcripts NM_205768   
Expression
Putative miRNA Targets on ZBTB18
3'UTR of ZBTB18
(miRNA target sites are highlighted)		 
>ZBTB18|NM_006352|3'UTR
   1 TTTTATATATATATAAATAATATATATATATATACATATATATAAATAGATCTCTATATAGTTGTGGTACGGTCTAAAAG
  81 CAGTCTTGTTTCCTGGAAATAAAAAGTTGGGATATTAACTTGTTTTTGCACTTTAGAATAGCATGAGAATCTCACTAATT
 161 TAGCATTCTGATAAAAGAAACTTTAGAGCAAGTCAGAATAGAGAGGTGTTTTTCCTTTGAGGGGATAGGGGAAGTAAGCC
 241 AATAAGAACCTTTTAAACAAATCGTCCTGTCACAAAATGCTTTCATATGGCTTAATTTTGTCAACACTGCATTGTCTTTT
 321 GAGCTCTTTTTTCCCCCCCAACAAAGTTTTTTTGTTTTTTGTTTTTTTTTTTAAGTAGAAATTCCCTCCAGTTTTATTAG
 401 CCTCTTTATATGTCTCAAATTGCATGAATTTTTTCTGGCTGTTGGAAACCTGAATGCTTTTAGACCCAAATGGAAAATTT
 481 CTGAAATGCTGGATTATCTATTTTTAAACAAGCAGTTGACTTAAAACTTTCTGTGGCAACTTCTGGTTTTCTGACAGTTC
 561 CCAGTGAGAGAAATGCTGAAAGTACACTGGGATCACTGGGACACTGTCTTATGAAGGTTTGCTTGGGATGAAAAAGGATA
 641 TTGCAGCTTCAGCAGTGTTGAACTGTGTGTTTAAAAATGTGAATTACTGTTATTGTATACTGTAATTGATTACATGGGCT
 721 GGGGGGGTGTCAAAGAACTTGACAGGTTGTGTTGATGCTCTTAGTTGAGTCTTGAAAAGTAAATATTAACGCTACAGAAA
 801 TGCATGAGTTTCAATATATTTTTTGTCTTTGTTTGCATTGTATAACTTTAACGAGTGAGTTTAAAATTATTTAATTTCCT
 881 TAGAAAAATAGCACCATTTGGAAAAAAAAACTGGTGTTATGAAGAACGTAAATGCACTGTTTTTATTTTTATTTTATATA
 961 ATTTAAATTGACTTTCCCACTGTCTTTAAGTTGAAACTGTTAAGCTGAATAAAAACTTAAGCTGCAAATTGATAACTTCG
1041 CTACATAACAAGGAAAATATAAATGTTTACAAACAGCTTAAAGATTTGCATGTGCAGTGTGCATTTATAACAAACTTCTA
1121 ATTGCACAAAACCCATGCCAGCTCAGAGTTTAGGTGTACACATTTACCCAGTTGAGCGTTCTTAGAATAACTACTGCACA
1201 AGTTGACAATAGGTCGTTCTCTCTTTTTTTTTGTTTGCTCCCTTTTTCTTTTTCTCCCCTTCCTCCTTACCCTCCCTCCC
1281 TTACTCTCCCCCCCCACCACCACCCTCCACCCCCAACTCATGAAAAGATTCTATGGACTGAAAAAGCCCCAGGCTGAAAG
1361 GACTGGACTGCCTTGATTGACATGGGGAAGGGGGTTAGTAGACTATGTGGATTGCGGCAGCAGAGGCTGCAGCCTAACGT
1441 GTGGTTTTAATGACCAGCACGCAAGGCAAAAGCATTTTGCACAGTGTTTGTTTTCCTGTCTTGCACTTACAAATAAGGTC
1521 TATGGGAGTAGCATGGAAAACGTTTGCTGTTTTTCCCTTTTTTTTTTAATTGCTTTTGTTTAAAATTTGATCGCCTTAAC
1601 TACTGTAAACATAGCCTATTTTTGTGCTTAAGATACTGAATGGAAAACTCCATTGTGTGTTGCTGGACTGTTTTGGAAAT
1681 ATTTGGTTAAATGTGTGTTAATTTGGCTGTAATGGCATTTAAAGCAAACAAACAAACAAAAAAAGCTGTGAAAATGGCCT
1761 TGGAGCATTATCTTTAGTTACTTGAAGAGTTTCTAGTTTTTTTAAAATACAGTTTATGTTAAAATAATTTTTATTAATTT
1841 AGAGAAGACAATCAATGTCTGTGAGAAAACGGACTTTCTTTTGGATTTTCTTTTTGTGGTCATTGTGAGTGATTGCTTTT
1921 TCCTTTTCTTAGTTTCACATTCTTCCTTTGTTCTAAAACTTAGACTGACATCTAGCTTTGACAATCATAGTATGTTTTAT
2001 TTTCCTGAGGGGGAATAACTTATAATGCTGTTTAGTTTTGTACTATTGGTGTGTTGGTGAATTTTTAAACTGTGTGCTAA
2081 CTGCAATAAATTATATGAACTGAGAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' aucGUCGUACUU----GGACAGAg 5'
             |||::|  :    ||||||| 
Target 5' gcaCAGTGTTTGTTTTCCTGTCTt 3'
 1479 - 1502 143.00 -14.70
2 
miRNA  3' aucgucGUACUUGGACAGAg 5'
                :|| |||:|||:| 
Target 5' ttgggaTATTAACTTGTTTt 3'
 107 - 126 126.00 -8.70
3 
miRNA  3' aucgucgUACUUGGACAGag 5'
                 || : ||||||  
Target 5' taaacaaATCGTCCTGTCac 3'
 254 - 273 125.00 -8.50
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN28851020 15 COSMIC
COSN29527214 34 COSMIC
COSN30527935 36 COSMIC
COSN30119913 73 COSMIC
COSN15626972 130 COSMIC
COSN15626973 199 COSMIC
COSN31480259 220 COSMIC
COSN26641607 224 COSMIC
COSN26643198 303 COSMIC
COSN30127987 333 COSMIC
COSN30112245 354 COSMIC
COSN30129798 369 COSMIC
COSN27583566 373 COSMIC
COSN29025133 373 COSMIC
COSN30173544 474 COSMIC
COSN30142804 482 COSMIC
COSN31556061 602 COSMIC
COSN30530804 776 COSMIC
COSN31487514 807 COSMIC
COSN30125702 810 COSMIC
COSN17577866 820 COSMIC
COSN6450489 870 COSMIC
COSN22781609 911 COSMIC
COSN30136242 950 COSMIC
COSN30544456 984 COSMIC
COSN17076090 1021 COSMIC
COSN30121296 1028 COSMIC
COSN24298147 1055 COSMIC
COSN30540310 1093 COSMIC
COSN31596739 1102 COSMIC
COSN31592001 1112 COSMIC
COSN15626974 1233 COSMIC
COSN24298621 1239 COSMIC
COSN31597400 1271 COSMIC
COSN20842555 1280 COSMIC
COSN26481413 1288 COSMIC
COSN28696799 1295 COSMIC
COSN30119592 1312 COSMIC
COSN30116155 1313 COSMIC
COSN22207377 1376 COSMIC
COSN31590966 1408 COSMIC
COSN24132847 1496 COSMIC
COSN26957735 1539 COSMIC
COSN23012540 1558 COSMIC
COSN30141800 1593 COSMIC
COSN24294634 1596 COSMIC
COSN31482456 1622 COSMIC
COSN28241566 1624 COSMIC
COSN28821839 1670 COSMIC
COSN31534901 1684 COSMIC
COSN30127337 1745 COSMIC
COSN31543131 1804 COSMIC
COSN29968997 1813 COSMIC
COSN30114279 1832 COSMIC
COSN28250193 2004 COSMIC
COSN30125829 2073 COSMIC
COSN30134971 2080 COSMIC
COSN30113824 2105 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs751028118 4 dbSNP
rs757030500 4 dbSNP
rs754537426 5 dbSNP
rs1286045126 7 dbSNP
rs778553132 11 dbSNP
rs374525527 13 dbSNP
rs1283383178 17 dbSNP
rs112455960 20 dbSNP
rs564772339 20 dbSNP
rs747874887 20 dbSNP
rs780686374 20 dbSNP
rs1335224674 22 dbSNP
rs771903420 24 dbSNP
rs975176125 25 dbSNP
rs530527622 27 dbSNP
rs1393773715 28 dbSNP
rs1331916808 32 dbSNP
rs1401491656 32 dbSNP
rs1168840823 34 dbSNP
rs1421146862 34 dbSNP
rs572415612 34 dbSNP
rs1198191627 36 dbSNP
rs768181803 37 dbSNP
rs1471318636 38 dbSNP
rs776214706 40 dbSNP
rs953850286 47 dbSNP
rs1411704530 49 dbSNP
rs1475700116 51 dbSNP
rs1189782867 57 dbSNP
rs1440771024 61 dbSNP
rs985819588 65 dbSNP
rs1016861231 71 dbSNP
rs540045885 72 dbSNP
rs1256482203 73 dbSNP
rs1217645130 77 dbSNP
rs1444294262 115 dbSNP
rs998498504 116 dbSNP
rs1189248707 120 dbSNP
rs1285589377 126 dbSNP
rs188045468 127 dbSNP
rs972444847 133 dbSNP
rs1339344204 134 dbSNP
rs1309911421 142 dbSNP
rs1448855252 144 dbSNP
rs561551983 150 dbSNP
rs765946371 166 dbSNP
rs1405726706 173 dbSNP
rs921125095 173 dbSNP
rs939135480 174 dbSNP
rs554704783 180 dbSNP
rs953882947 185 dbSNP
rs547234645 187 dbSNP
rs761443658 192 dbSNP
rs1442022911 197 dbSNP
rs1338512653 205 dbSNP
rs1236866174 225 dbSNP
rs1380082027 227 dbSNP
rs991864533 231 dbSNP
rs916787644 243 dbSNP
rs948247251 250 dbSNP
rs1044246749 256 dbSNP
rs904116200 257 dbSNP
rs935555745 258 dbSNP
rs1207645383 259 dbSNP
rs1052469526 264 dbSNP
rs567021773 265 dbSNP
rs1374651221 271 dbSNP
rs1213258277 274 dbSNP
rs150441259 276 dbSNP
rs1332587178 287 dbSNP
rs77915082 287 dbSNP
rs1325805260 301 dbSNP
rs1403747805 302 dbSNP
rs1365048066 306 dbSNP
rs1159384828 307 dbSNP
rs920985730 318 dbSNP
rs1261710333 324 dbSNP
rs1460997765 325 dbSNP
rs192465744 327 dbSNP
rs543994510 327 dbSNP
rs1050497148 328 dbSNP
rs1036299170 329 dbSNP
rs1283540130 333 dbSNP
rs889172096 333 dbSNP
rs919356879 333 dbSNP
rs1006739060 335 dbSNP
rs1346901289 336 dbSNP
rs1017156832 337 dbSNP
rs962682394 338 dbSNP
rs569201540 339 dbSNP
rs930759147 340 dbSNP
rs538216631 344 dbSNP
rs994480404 346 dbSNP
rs1345182836 347 dbSNP
rs1186062151 348 dbSNP
rs1298993624 350 dbSNP
rs1049116717 355 dbSNP
rs1401977530 355 dbSNP
rs1159055413 359 dbSNP
rs1480312212 362 dbSNP
rs557006976 362 dbSNP
rs562378230 362 dbSNP
rs894674661 363 dbSNP
rs772542071 369 dbSNP
rs796078285 376 dbSNP
rs1046412013 387 dbSNP
rs1178275189 387 dbSNP
rs1313937298 389 dbSNP
rs1276405565 392 dbSNP
rs907412648 396 dbSNP
rs998944549 399 dbSNP
rs1031311307 402 dbSNP
rs1011353095 405 dbSNP
rs892792921 405 dbSNP
rs1468913368 409 dbSNP
rs960361240 411 dbSNP
rs1318572715 412 dbSNP
rs1448833553 415 dbSNP
rs991747681 425 dbSNP
rs916337928 428 dbSNP
rs1346667900 429 dbSNP
rs183884013 434 dbSNP
rs536095853 436 dbSNP
rs377042727 442 dbSNP
rs1346666110 446 dbSNP
rs1225904778 465 dbSNP
rs1281707157 466 dbSNP
rs1323276682 467 dbSNP
rs552758985 468 dbSNP
rs1418330962 477 dbSNP
rs925422956 489 dbSNP
rs369080519 492 dbSNP
rs1483927163 505 dbSNP
rs1206157304 507 dbSNP
rs1235709946 510 dbSNP
rs961291156 514 dbSNP
rs1458071505 521 dbSNP
rs972613050 524 dbSNP
rs572692786 537 dbSNP
rs1200771821 540 dbSNP
rs919283779 542 dbSNP
rs1295123765 554 dbSNP
rs1286591820 558 dbSNP
rs935625263 559 dbSNP
rs1445543768 562 dbSNP
rs1215118914 564 dbSNP
rs1247396351 571 dbSNP
rs762531975 572 dbSNP
rs1490479097 575 dbSNP
rs1452498553 577 dbSNP
rs1052679445 580 dbSNP
rs1460781173 588 dbSNP
rs930643210 589 dbSNP
rs1165006944 591 dbSNP
rs923304523 596 dbSNP
rs866874506 601 dbSNP
rs915963726 607 dbSNP
rs544826509 612 dbSNP
rs1239922421 618 dbSNP
rs1158992920 623 dbSNP
rs1480170473 628 dbSNP
rs188369566 630 dbSNP
rs1251018567 636 dbSNP
rs889224430 639 dbSNP
rs1323615523 641 dbSNP
rs772491509 643 dbSNP
rs1245907655 644 dbSNP
rs1006700246 645 dbSNP
rs1312054290 647 dbSNP
rs1390074303 667 dbSNP
rs1038237586 669 dbSNP
rs1459059105 679 dbSNP
rs1316974765 684 dbSNP
rs561715194 693 dbSNP
rs573684654 694 dbSNP
rs994139839 700 dbSNP
rs1176679077 710 dbSNP
rs750135496 712 dbSNP
rs1011236726 721 dbSNP
rs892844308 721 dbSNP
rs1025520258 727 dbSNP
rs1267029579 732 dbSNP
rs1221889345 738 dbSNP
rs1354475625 743 dbSNP
rs1288806477 744 dbSNP
rs1301828010 750 dbSNP
rs1237467235 757 dbSNP
rs960576256 777 dbSNP
rs1302346650 780 dbSNP
rs1388874083 781 dbSNP
rs1343327301 790 dbSNP
rs1013217001 791 dbSNP
rs766265606 792 dbSNP
rs1281691865 793 dbSNP
rs1400134397 809 dbSNP
rs755552363 815 dbSNP
rs1008493048 819 dbSNP
rs1156776419 826 dbSNP
rs1378006086 827 dbSNP
rs1223460881 828 dbSNP
rs540991871 838 dbSNP
rs979577960 843 dbSNP
rs1427517047 850 dbSNP
rs564973400 852 dbSNP
rs576235298 853 dbSNP
rs1265340766 854 dbSNP
rs759304776 861 dbSNP
rs957089038 870 dbSNP
rs1266676898 871 dbSNP
rs1257092707 885 dbSNP
rs767340999 889 dbSNP
rs2486536 892 dbSNP
rs112925657 893 dbSNP
rs1218821383 896 dbSNP
rs1341843270 900 dbSNP
rs772960227 902 dbSNP
rs972665297 902 dbSNP
rs113046403 903 dbSNP
rs1468228340 907 dbSNP
rs1157653308 909 dbSNP
rs952055503 911 dbSNP
rs1385545285 912 dbSNP
rs1374988858 914 dbSNP
rs1191203861 915 dbSNP
rs984717027 919 dbSNP
rs1202653323 921 dbSNP
rs1257544952 921 dbSNP
rs933537242 924 dbSNP
rs1050440546 928 dbSNP
rs1262841048 929 dbSNP
rs1161177187 935 dbSNP
rs1319637261 940 dbSNP
rs1365484942 940 dbSNP
rs1226117905 944 dbSNP
rs910530966 978 dbSNP
rs942164097 980 dbSNP
rs1450272614 981 dbSNP
rs1405099669 982 dbSNP
rs1331854501 983 dbSNP
rs1038191315 986 dbSNP
rs1466988195 1014 dbSNP
rs530418831 1018 dbSNP
rs76217721 1020 dbSNP
rs560704968 1021 dbSNP
rs1369092861 1029 dbSNP
rs1185971012 1033 dbSNP
rs1046849511 1037 dbSNP
rs1361944340 1038 dbSNP
rs532736019 1040 dbSNP
rs1013435408 1041 dbSNP
rs934811620 1044 dbSNP
rs1194833954 1045 dbSNP
rs552418471 1046 dbSNP
rs879426603 1054 dbSNP
rs904848700 1055 dbSNP
rs1000659553 1063 dbSNP
rs1382029688 1065 dbSNP
rs1032507661 1091 dbSNP
rs956448215 1093 dbSNP
rs1448783312 1097 dbSNP
rs866828062 1098 dbSNP
rs372719731 1100 dbSNP
rs1327142327 1104 dbSNP
rs1409537190 1109 dbSNP
rs1391564295 1113 dbSNP
rs1049378571 1114 dbSNP
rs1422822743 1118 dbSNP
rs1030488087 1136 dbSNP
rs192588978 1146 dbSNP
rs986375285 1152 dbSNP
rs910595581 1158 dbSNP
rs559418394 1159 dbSNP
rs548182329 1161 dbSNP
rs1270587723 1163 dbSNP
rs919347303 1170 dbSNP
rs1243344531 1173 dbSNP
rs1219667806 1175 dbSNP
rs897028582 1178 dbSNP
rs1313455712 1179 dbSNP
rs112497158 1182 dbSNP
rs1046901064 1188 dbSNP
rs952607538 1190 dbSNP
rs536187559 1194 dbSNP
rs1462885183 1206 dbSNP
rs1364990671 1210 dbSNP
rs1299345408 1216 dbSNP
rs113079109 1217 dbSNP
rs1406405115 1218 dbSNP
rs199884785 1218 dbSNP
rs201027584 1218 dbSNP
rs141472162 1222 dbSNP
rs1431037444 1222 dbSNP
rs928701247 1222 dbSNP
rs981587611 1222 dbSNP
rs1395038730 1223 dbSNP
rs111838953 1224 dbSNP
rs1445272602 1224 dbSNP
rs564462241 1224 dbSNP
rs572093981 1224 dbSNP
rs80343896 1224 dbSNP
rs988957178 1224 dbSNP
rs1221839774 1225 dbSNP
rs74151279 1226 dbSNP
rs1432969711 1230 dbSNP
rs200817417 1230 dbSNP
rs1337846380 1233 dbSNP
rs1385232426 1234 dbSNP
rs1450750084 1237 dbSNP
rs1314416601 1238 dbSNP
rs1327103266 1239 dbSNP
rs1229784952 1241 dbSNP
rs116488334 1244 dbSNP
rs1337417847 1249 dbSNP
rs1415425073 1250 dbSNP
rs1197757762 1255 dbSNP
rs1408708056 1258 dbSNP
rs1173820934 1266 dbSNP
rs1479873975 1269 dbSNP
rs1263556100 1270 dbSNP
rs1462347152 1271 dbSNP
rs1423882248 1276 dbSNP
rs1201391374 1278 dbSNP
rs1254793494 1280 dbSNP
rs1428579553 1282 dbSNP
rs1194781354 1284 dbSNP
rs1371812640 1286 dbSNP
rs1477807125 1287 dbSNP
rs1050414640 1288 dbSNP
rs1202779942 1288 dbSNP
rs1210673908 1288 dbSNP
rs1323175726 1288 dbSNP
rs1177535886 1289 dbSNP
rs558434683 1290 dbSNP
rs1216452940 1292 dbSNP
rs1408795136 1293 dbSNP
rs575317188 1294 dbSNP
rs1407739272 1295 dbSNP
rs189663377 1295 dbSNP
rs1446431885 1296 dbSNP
rs554612217 1296 dbSNP
rs913575643 1297 dbSNP
rs943695600 1298 dbSNP
rs965520749 1298 dbSNP
rs1383969256 1300 dbSNP
rs1293589004 1303 dbSNP
rs1305843024 1306 dbSNP
rs1324567655 1307 dbSNP
rs753456145 1309 dbSNP
rs1283612716 1310 dbSNP
rs1385711881 1311 dbSNP
rs1313521473 1313 dbSNP
rs1325442207 1314 dbSNP
rs1221521681 1315 dbSNP
rs1255045041 1316 dbSNP
rs1374454894 1317 dbSNP
rs1299562898 1318 dbSNP
rs1486012625 1319 dbSNP
rs1000946649 1321 dbSNP
rs1439492661 1322 dbSNP
rs1206358191 1324 dbSNP
rs1163739020 1328 dbSNP
rs1031983583 1330 dbSNP
rs1162788654 1331 dbSNP
rs993979432 1334 dbSNP
rs748562650 1342 dbSNP
rs1179192309 1349 dbSNP
rs1009306677 1350 dbSNP
rs1232485718 1351 dbSNP
rs1030539014 1352 dbSNP
rs1048186149 1354 dbSNP
rs1290232091 1355 dbSNP
rs954858455 1367 dbSNP
rs888266565 1368 dbSNP
rs1012187690 1371 dbSNP
rs1222395883 1373 dbSNP
rs370480862 1375 dbSNP
rs1479661441 1376 dbSNP
rs1018282895 1378 dbSNP
rs879622076 1381 dbSNP
rs970115859 1384 dbSNP
rs963637034 1385 dbSNP
rs540973799 1386 dbSNP
rs1302506754 1388 dbSNP
rs973828667 1389 dbSNP
rs1035776759 1391 dbSNP
rs919244800 1394 dbSNP
rs560745566 1395 dbSNP
rs1287150862 1396 dbSNP
rs1407601667 1404 dbSNP
rs532629166 1407 dbSNP
rs1266808131 1409 dbSNP
rs992862782 1413 dbSNP
rs1486504470 1414 dbSNP
rs914768822 1415 dbSNP
rs917788517 1416 dbSNP
rs949224452 1417 dbSNP
rs1224926497 1418 dbSNP
rs985765340 1421 dbSNP
rs1044870527 1423 dbSNP
rs943721339 1435 dbSNP
rs546391903 1439 dbSNP
rs1280196054 1440 dbSNP
rs976800792 1442 dbSNP
rs1452802584 1448 dbSNP
rs1406455917 1455 dbSNP
rs1177455193 1461 dbSNP
rs918348665 1462 dbSNP
rs1427427507 1465 dbSNP
rs1198336359 1468 dbSNP
rs138191545 1473 dbSNP
rs772952772 1475 dbSNP
rs1203836430 1484 dbSNP
rs1485764636 1509 dbSNP
rs892128610 1511 dbSNP
rs1048114285 1513 dbSNP
rs1205945016 1518 dbSNP
rs867859125 1523 dbSNP
rs1262114508 1530 dbSNP
rs1227589217 1534 dbSNP
rs1051514605 1535 dbSNP
rs1300387697 1538 dbSNP
rs1317086567 1542 dbSNP
rs530880823 1543 dbSNP
rs890176700 1546 dbSNP
rs1381533371 1548 dbSNP
rs1383280957 1555 dbSNP
rs1338508351 1556 dbSNP
rs1404261407 1558 dbSNP
rs142367529 1558 dbSNP
rs1468036782 1558 dbSNP
rs1008155658 1561 dbSNP
rs1462567541 1563 dbSNP
rs548867956 1564 dbSNP
rs181883883 1568 dbSNP
rs995084680 1569 dbSNP
rs1222677239 1570 dbSNP
rs1271648148 1573 dbSNP
rs1490017836 1574 dbSNP
rs1244258101 1577 dbSNP
rs1002890999 1594 dbSNP
rs1026764840 1604 dbSNP
rs1242157928 1605 dbSNP
rs1195949103 1619 dbSNP
rs1340896512 1631 dbSNP
rs1249058059 1634 dbSNP
rs1251732032 1635 dbSNP
rs1421038529 1639 dbSNP
rs1360164791 1654 dbSNP
rs1317063713 1655 dbSNP
rs1157213831 1659 dbSNP
rs1035724777 1667 dbSNP
rs891785157 1684 dbSNP
rs1333794606 1685 dbSNP
rs1379981908 1698 dbSNP
rs1392132703 1705 dbSNP
rs1425373640 1706 dbSNP
rs950717139 1710 dbSNP
rs992749239 1714 dbSNP
rs1010366327 1725 dbSNP
rs202153295 1725 dbSNP
rs968923106 1729 dbSNP
rs1367344491 1730 dbSNP
rs917338805 1731 dbSNP
rs1434238988 1734 dbSNP
rs1292687827 1735 dbSNP
rs1018547171 1738 dbSNP
rs185811018 1738 dbSNP
rs985992888 1738 dbSNP
rs970085992 1742 dbSNP
rs1247978883 1745 dbSNP
rs1203894843 1746 dbSNP
rs965984848 1761 dbSNP
rs778949959 1763 dbSNP
rs981037702 1769 dbSNP
rs189435496 1773 dbSNP
rs1358494500 1782 dbSNP
rs1279974400 1784 dbSNP
rs926465847 1787 dbSNP
rs1337824760 1792 dbSNP
rs936618697 1796 dbSNP
rs1409299848 1797 dbSNP
rs747872246 1807 dbSNP
rs1373790262 1808 dbSNP
rs1053706904 1813 dbSNP
rs1305518132 1828 dbSNP
rs1423232201 1831 dbSNP
rs765837609 1849 dbSNP
rs1304390629 1851 dbSNP
rs1159580393 1857 dbSNP
rs1471356324 1864 dbSNP
rs568163000 1871 dbSNP
rs527660466 1872 dbSNP
rs1293350384 1877 dbSNP
rs181953360 1879 dbSNP
rs1221484181 1887 dbSNP
rs945034957 1892 dbSNP
rs1451007531 1897 dbSNP
rs1481816578 1900 dbSNP
rs1284863636 1901 dbSNP
rs1175915620 1904 dbSNP
rs1206734319 1905 dbSNP
rs1348202847 1910 dbSNP
rs909599863 1911 dbSNP
rs947913083 1914 dbSNP
rs1051401391 1916 dbSNP
rs3210202 1918 dbSNP
rs890229528 1925 dbSNP
rs1445519780 1943 dbSNP
rs1045276240 1944 dbSNP
rs1185440997 1947 dbSNP
rs1403144315 1951 dbSNP
rs1349873133 1952 dbSNP
rs142796285 1956 dbSNP
rs538530248 1962 dbSNP
rs1403468710 1973 dbSNP
rs1402815379 1975 dbSNP
rs1383213179 1977 dbSNP
rs939291367 1978 dbSNP
rs1480587597 1983 dbSNP
rs1430937352 1984 dbSNP
rs1477400727 2003 dbSNP
rs1242644378 2006 dbSNP
rs1195156815 2009 dbSNP
rs1164005723 2013 dbSNP
rs1267202845 2016 dbSNP
rs774241187 2024 dbSNP
rs759537637 2046 dbSNP
rs1324583836 2048 dbSNP
rs899321795 2057 dbSNP
rs767285921 2066 dbSNP
rs1265222630 2071 dbSNP
rs1217564291 2073 dbSNP
rs1355097691 2074 dbSNP
rs1463307511 2084 dbSNP
rs891838344 2092 dbSNP
rs1433445731 2093 dbSNP
rs1010208736 2094 dbSNP
rs1329113902 2095 dbSNP
rs1325179344 2098 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM545213. RNA binding protein: AGO2. Condition:Control PAR-CLIP data was present in GSM545216. RNA binding protein: AGO2. Condition:miR-124 transfection PAR-CLIP data was present in GSM545217. RNA binding protein: AGO2. Condition:miR-7 transfection ...

- Hafner M; Landthaler M; Burger L; Khorshid et al., 2010, Cell.

Article - Hafner M; Landthaler M; Burger L; Khorshid et al.
- Cell, 2010
RNA transcripts are subject to posttranscriptional gene regulation involving hundreds of RNA-binding proteins (RBPs) and microRNA-containing ribonucleoprotein complexes (miRNPs) expressed in a cell-type dependent fashion. We developed a cell-based crosslinking approach to determine at high resolution and transcriptome-wide the binding sites of cellular RBPs and miRNPs. The crosslinked sites are revealed by thymidine to cytidine transitions in the cDNAs prepared from immunopurified RNPs of 4-thiouridine-treated cells. We determined the binding sites and regulatory consequences for several intensely studied RBPs and miRNPs, including PUM2, QKI, IGF2BP1-3, AGO/EIF2C1-4 and TNRC6A-C. Our study revealed that these factors bind thousands of sites containing defined sequence motifs and have distinct preferences for exonic versus intronic or coding versus untranslated transcript regions. The precise mapping of binding sites across the transcriptome will be critical to the interpretation of the rapidly emerging data on genetic variation between individuals and how these variations contribute to complex genetic diseases.
LinkOut: [PMID: 20371350]
CLIP-seq Support 1 for dataset GSM545213
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / Control
Location of target site ENST00000358704.4 | 3UTR | UUUUCCUGUCUUGCACUUA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 20371350 / GSE21578
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM545216
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / miR-124 transfection
Location of target site ENST00000358704.4 | 3UTR | UUUUCCUGUCUUGCACUUACAAAUAAGGUCUAUGGGAGUAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 20371350 / GSE21578
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM545217
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / miR-7 transfection
Location of target site ENST00000358704.4 | 3UTR | UUUUCCUGUCUUGCACUUACAAAUAAGGUCUAUGGGAGUA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 20371350 / GSE21578
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
175 hsa-miR-4524b-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT064889 ZBTB18 zinc finger and BTB domain containing 18 2 2
MIRT075345 SF3B3 splicing factor 3b subunit 3 2 2
MIRT094174 PCGF3 polycomb group ring finger 3 2 6
MIRT100109 ABT1 activator of basal transcription 1 2 8
MIRT102242 HBP1 HMG-box transcription factor 1 2 2
MIRT124918 HCCS holocytochrome c synthase 2 2
MIRT140195 CHAC1 ChaC glutathione specific gamma-glutamylcyclotransferase 1 2 2
MIRT193891 HACD3 3-hydroxyacyl-CoA dehydratase 3 2 2
MIRT265634 LDHA lactate dehydrogenase A 2 2
MIRT303878 VAMP8 vesicle associated membrane protein 8 2 2
MIRT409756 CRTAP cartilage associated protein 2 4
MIRT441503 SPG20 spartin 2 6
MIRT446882 ZNF554 zinc finger protein 554 2 2
MIRT447093 COPRS coordinator of PRMT5 and differentiation stimulator 2 2
MIRT449987 AEN apoptosis enhancing nuclease 2 2
MIRT452116 IFITM1 interferon induced transmembrane protein 1 2 2
MIRT452654 ZNF33A zinc finger protein 33A 2 2
MIRT453886 IFRD1 interferon related developmental regulator 1 2 12
MIRT454143 FOXRED2 FAD dependent oxidoreductase domain containing 2 2 2
MIRT454501 SLC29A1 solute carrier family 29 member 1 (Augustine blood group) 2 2
MIRT456633 ARMCX6 armadillo repeat containing, X-linked 6 2 2
MIRT457021 ACADSB acyl-CoA dehydrogenase, short/branched chain 2 2
MIRT457055 NEGR1 neuronal growth regulator 1 2 2
MIRT457335 REG4 regenerating family member 4 2 2
MIRT457421 CASC5 kinetochore scaffold 1 2 2
MIRT457940 LCE1A late cornified envelope 1A 2 2
MIRT458486 RMI1 RecQ mediated genome instability 1 2 10
MIRT458662 PAGR1 PAXIP1 associated glutamate rich protein 1 2 12
MIRT459784 IDH3A isocitrate dehydrogenase 3 (NAD(+)) alpha 2 2
MIRT459864 SVOP SV2 related protein 2 2
MIRT460575 FEM1A fem-1 homolog A 2 2
MIRT460987 STK17B serine/threonine kinase 17b 2 2
MIRT462315 TMEM109 transmembrane protein 109 2 2
MIRT464407 URM1 ubiquitin related modifier 1 2 2
MIRT465148 TSC22D2 TSC22 domain family member 2 2 2
MIRT466312 TIMM22 translocase of inner mitochondrial membrane 22 2 2
MIRT466718 SYNJ2BP synaptojanin 2 binding protein 2 2
MIRT468258 SFXN4 sideroflexin 4 2 2
MIRT469140 RNF126 ring finger protein 126 2 2
MIRT471783 NUP153 nucleoporin 153 2 2
MIRT472506 NACC2 NACC family member 2 2 2
MIRT474588 KLF6 Kruppel like factor 6 2 2
MIRT475049 JOSD1 Josephin domain containing 1 2 2
MIRT476900 FBXO21 F-box protein 21 2 2
MIRT476972 FAM83G family with sequence similarity 83 member G 2 4
MIRT477433 EMP1 epithelial membrane protein 1 2 2
MIRT480334 C5orf51 chromosome 5 open reading frame 51 2 10
MIRT481179 AVL9 AVL9 cell migration associated 2 6
MIRT481693 AR androgen receptor 2 2
MIRT483280 HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 2 4
MIRT485775 B4GALT5 beta-1,4-galactosyltransferase 5 2 2
MIRT487424 CACNB1 calcium voltage-gated channel auxiliary subunit beta 1 2 2
MIRT488002 RXRB retinoid X receptor beta 2 2
MIRT488259 DNLZ DNL-type zinc finger 2 4
MIRT490360 DPYSL5 dihydropyrimidinase like 5 2 2
MIRT491593 USB1 U6 snRNA biogenesis phosphodiesterase 1 2 2
MIRT495269 IGF2BP1 insulin like growth factor 2 mRNA binding protein 1 2 4
MIRT495619 ZNF736 zinc finger protein 736 2 2
MIRT496167 ELP3 elongator acetyltransferase complex subunit 3 2 2
MIRT496250 GJB2 gap junction protein beta 2 2 2
MIRT496915 RTKN rhotekin 2 2
MIRT498713 PGAM5 PGAM family member 5, mitochondrial serine/threonine protein phosphatase 2 10
MIRT501106 SLC5A6 solute carrier family 5 member 6 2 4
MIRT501831 NCOA3 nuclear receptor coactivator 3 2 2
MIRT507142 GIGYF1 GRB10 interacting GYF protein 1 2 2
MIRT510991 PER1 period circadian clock 1 2 4
MIRT512283 ARHGDIA Rho GDP dissociation inhibitor alpha 2 6
MIRT513152 CSDC2 cold shock domain containing C2 2 2
MIRT513327 KCNMB1 potassium calcium-activated channel subfamily M regulatory beta subunit 1 2 6
MIRT515090 FAM120AOS family with sequence similarity 120A opposite strand 2 2
MIRT516113 OARD1 O-acyl-ADP-ribose deacylase 1 2 8
MIRT516657 PIGP phosphatidylinositol glycan anchor biosynthesis class P 2 2
MIRT516892 PLEKHS1 pleckstrin homology domain containing S1 2 2
MIRT517966 ZMIZ2 zinc finger MIZ-type containing 2 2 4
MIRT519492 PNPLA3 patatin like phospholipase domain containing 3 2 2
MIRT519799 ZNF226 zinc finger protein 226 2 2
MIRT524309 CTC1 CST telomere replication complex component 1 2 8
MIRT524425 CNKSR3 CNKSR family member 3 2 2
MIRT525927 KIAA0391 KIAA0391 2 2
MIRT528022 ACOT9 acyl-CoA thioesterase 9 2 2
MIRT528227 METTL8 methyltransferase like 8 2 2
MIRT528686 CEP57L1 centrosomal protein 57 like 1 2 2
MIRT528774 CD1D CD1d molecule 2 2
MIRT529935 P2RX7 purinergic receptor P2X 7 2 2
MIRT530642 PPIC peptidylprolyl isomerase C 2 4
MIRT530683 CHRNB1 cholinergic receptor nicotinic beta 1 subunit 2 4
MIRT531922 SLC4A1 solute carrier family 4 member 1 (Diego blood group) 2 2
MIRT532181 SEC14L5 SEC14 like lipid binding 5 2 4
MIRT534996 PRR11 proline rich 11 2 6
MIRT535452 PDCL phosducin like 2 4
MIRT544682 AP1S1 adaptor related protein complex 1 sigma 1 subunit 2 2
MIRT553757 TARBP2 TARBP2, RISC loading complex RNA binding subunit 2 4
MIRT560724 ZNF749 zinc finger protein 749 2 2
MIRT561518 SPTY2D1 SPT2 chromatin protein domain containing 1 2 2
MIRT561578 SLC30A1 solute carrier family 30 member 1 2 2
MIRT562483 CHORDC1 cysteine and histidine rich domain containing 1 2 2
MIRT565039 VAV2 vav guanine nucleotide exchange factor 2 2 2
MIRT565348 TMED4 transmembrane p24 trafficking protein 4 2 2
MIRT567104 KANSL1 KAT8 regulatory NSL complex subunit 1 2 2
MIRT568879 LY6H lymphocyte antigen 6 family member H 2 2
MIRT569141 NAP1L4 nucleosome assembly protein 1 like 4 2 2
MIRT569199 LRRC3C leucine rich repeat containing 3C 2 2
MIRT573559 TMEM120B transmembrane protein 120B 2 2
MIRT575931 Mrrf mitochondrial ribosome recycling factor 2 6
MIRT607035 MRRF mitochondrial ribosome recycling factor 2 9
MIRT607194 SPRY4 sprouty RTK signaling antagonist 4 2 2
MIRT609682 TMEM213 transmembrane protein 213 2 2
MIRT611227 ZNF274 zinc finger protein 274 2 2
MIRT611370 PLXDC1 plexin domain containing 1 2 4
MIRT611640 SCRG1 stimulator of chondrogenesis 1 2 2
MIRT613011 GABRB1 gamma-aminobutyric acid type A receptor beta1 subunit 2 2
MIRT613532 GTSE1 G2 and S-phase expressed 1 2 2
MIRT614459 REL REL proto-oncogene, NF-kB subunit 2 2
MIRT616492 CD300E CD300e molecule 2 2
MIRT617288 GTF2H3 general transcription factor IIH subunit 3 2 2
MIRT618356 CDKL1 cyclin dependent kinase like 1 2 2
MIRT619529 ZNF74 zinc finger protein 74 2 2
MIRT619990 ZSCAN22 zinc finger and SCAN domain containing 22 2 2
MIRT621286 ATP5E ATP synthase, H+ transporting, mitochondrial F1 complex, epsilon subunit 2 2
MIRT621482 GPKOW G-patch domain and KOW motifs 2 2
MIRT625456 RANGAP1 Ran GTPase activating protein 1 2 2
MIRT626757 NDUFA9 NADH:ubiquinone oxidoreductase subunit A9 2 2
MIRT629138 CTCFL CCCTC-binding factor like 2 2
MIRT630092 DCAF10 DDB1 and CUL4 associated factor 10 2 2
MIRT633501 RNF14 ring finger protein 14 2 2
MIRT633604 APCDD1 APC down-regulated 1 2 2
MIRT633772 F2 coagulation factor II, thrombin 2 2
MIRT635605 ADAT1 adenosine deaminase, tRNA specific 1 2 2
MIRT637422 EPB41L3 erythrocyte membrane protein band 4.1 like 3 2 2
MIRT637822 PLA2G7 phospholipase A2 group VII 2 2
MIRT637978 RRP36 ribosomal RNA processing 36 2 2
MIRT638385 RABL3 RAB, member of RAS oncogene family like 3 2 2
MIRT638547 KIAA1549 KIAA1549 2 2
MIRT642019 NCKIPSD NCK interacting protein with SH3 domain 2 2
MIRT643342 MICA MHC class I polypeptide-related sequence A 2 2
MIRT644281 LRRC57 leucine rich repeat containing 57 2 2
MIRT646818 COX19 COX19, cytochrome c oxidase assembly factor 2 2
MIRT646839 TLDC1 TBC/LysM-associated domain containing 1 2 2
MIRT646976 CYP2W1 cytochrome P450 family 2 subfamily W member 1 2 2
MIRT647735 CXCR2 C-X-C motif chemokine receptor 2 2 2
MIRT648598 ZYG11B zyg-11 family member B, cell cycle regulator 2 2
MIRT649843 LIPG lipase G, endothelial type 2 2
MIRT650031 VHL von Hippel-Lindau tumor suppressor 2 2
MIRT652082 TSPAN14 tetraspanin 14 2 2
MIRT652103 TRUB2 TruB pseudouridine synthase family member 2 2 2
MIRT652902 SYNPO2L synaptopodin 2 like 2 2
MIRT653549 SLC38A7 solute carrier family 38 member 7 2 2
MIRT653981 SEMA6B semaphorin 6B 2 2
MIRT654287 RCAN1 regulator of calcineurin 1 2 2
MIRT658372 FAM63B MINDY lysine 48 deubiquitinase 2 2 2
MIRT660321 BDP1 B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB 2 2
MIRT663063 LRIF1 ligand dependent nuclear receptor interacting factor 1 2 2
MIRT663269 ATP1A2 ATPase Na+/K+ transporting subunit alpha 2 2 2
MIRT664076 ZNF417 zinc finger protein 417 2 2
MIRT664193 MYOZ2 myozenin 2 2 2
MIRT664512 POLR3K RNA polymerase III subunit K 2 2
MIRT667025 PDF peptide deformylase, mitochondrial 2 2
MIRT669621 ACSL6 acyl-CoA synthetase long chain family member 6 2 2
MIRT670530 MLLT6 MLLT6, PHD finger containing 2 2
MIRT673050 SGPL1 sphingosine-1-phosphate lyase 1 2 2
MIRT683339 ZNF581 zinc finger protein 581 2 2
MIRT689264 WDR83OS WD repeat domain 83 opposite strand 2 2
MIRT690902 TOP2A DNA topoisomerase II alpha 2 2
MIRT699196 SLX4IP SLX4 interacting protein 2 2
MIRT702223 LONRF3 LON peptidase N-terminal domain and ring finger 3 2 2
MIRT707053 TRPV2 transient receptor potential cation channel subfamily V member 2 2 2
MIRT707080 MED29 mediator complex subunit 29 2 2
MIRT712347 NLN neurolysin 2 2
MIRT714715 KIT KIT proto-oncogene receptor tyrosine kinase 2 2
MIRT715963 CES4A carboxylesterase 4A 2 2
MIRT718224 DEFB105B defensin beta 105B 2 2
MIRT718244 DEFB105A defensin beta 105A 2 2
MIRT721960 GCK glucokinase 2 2
MIRT723098 SERINC3 serine incorporator 3 2 2
MIRT725207 PTPRT protein tyrosine phosphatase, receptor type T 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-4524b Tripterygium wilfordii Hook F resistant tissue
hsa-miR-4524b-3p Tamoxifen 2733525 NSC180973 approved sensitive cell line (LCC2)

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