miRTarBase - #MIRT065801


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pre-miRNA Information
pre-miRNA hsa-mir-6808   
Genomic Coordinates chr1: 1339650 - 1339708
Description Homo sapiens miR-6808 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-6808-5p
Sequence 6| CAGGCAGGGAGGUGGGACCAUG |27
Evidence Experimental
Experiments Meta-analysis
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs200363718 2 dbSNP
rs781187339 3 dbSNP
rs1175964401 5 dbSNP
rs377360440 9 dbSNP
rs1284899234 12 dbSNP
rs747433206 13 dbSNP
rs1431822851 14 dbSNP
rs1342544357 19 dbSNP
rs751585831 20 dbSNP
rs763913520 21 dbSNP
rs755106743 22 dbSNP
Putative Targets

Gene Information
Gene Symbol HOXC8   
Synonyms HOX3, HOX3A
Description homeobox C8
Transcript NM_022658   
Expression
Putative miRNA Targets on HOXC8
3'UTR of HOXC8
(miRNA target sites are highlighted)		 
>HOXC8|NM_022658|3'UTR
   1 GCAAAAAAGAAAGACCCCCCCCCCCTTAGCAACTCCCTTGAAGTTTCGTTTTATGGTAGCAGATAAATTGAGAAGTTTAC
  81 GACTGTCATTTGCTTTTATAGAGAATAGAATGACACTCACAACTCTAACTACCTGTCAGATACTTGCAGCTCTGGTTTTA
 161 TTACCTTTGGACTTCCCCCACTCTTTATTTGTTTGGGGGCTGGAGGGGGGAGACGGAGAAACAGTGAAAAGTTCGGACTC
 241 TCTGTCTCACTCCTTGCCCCACACACACTTGTCCCTGCCCCCACCCTTCTGAGTCCTTCCTGGATTTTAAGGTCTGAGAC
 321 CTGGCCTCCGTGCTCCTCGGTCTGTCTCTCACCACACTCCCACCTCCCTGCTTCTCTGGTATTTATTTTAGAGGGGAGCC
 401 CCCTCGAAATGCAGAAAAGGACTTGTGGTTTTGTTTTTATGCTAAGGCTAGTGTACTAGATGTACTTTTTCTAAAAAGGA
 481 AAGGACAGAAAAAAATGAAGAAAGGAAAGGAAGACAAATGTAAAGAAATAAGGAAAAAAGCAAGGAATATCCCCTCCCCC
 561 TCCCCCTCCCCCTCCCCAGGGCTCCCTGCTTAGAAAAACCCCCTTGACTTTCTCTAGGAACCTGATGGAAACCTGAAGGA
 641 GATGTGGGTCTTTCCCCTCCCCCCATTTCCAGAAGGGTAGATAGGAGCCTGCAGTCGCCTCTAAAATCCTACCTAACCAT
 721 CCCATGGTCACTCGGGCCCATGCCTTCCTCTCCTTCGCTGTTTGATTTCTATTCTGTTGGGCCCGCCTTCCTCTGAGCTG
 801 CATTAGTGTTAGTGCTCAGAAATCACCATAATCACGAAAATAATAATAATAAATCTTTAACATACTACCTAAAGGGAACC
 881 TGCAATAATCTTGAAAAAGAAAAAGAGAAAAATTTTAAAATCCTGCTATAGGAGAAAAAAAGAGAAAAAAATAAAAATCA
 961 AAAAAAAAAAAAAGAAAGAAAGAAACCTCCAGCGTATTTTATCACTACCTATAGAAAGAAATCCTGCTTTGAGAGTATTT
1041 GTAATGCGGTTTTGTTGTCGTTTGTTGCTGCTTATTTCACTAAGAAAACCCAACAACTGAGACTGCCTAGCCCGCCGGTC
1121 CTGTGCGCTTTTATTGTGCTTCTAACCCCAGTAGAGTAGAACTAAATTGCACTGAATGTATAGTTAACTCTGTCTTGAAT
1201 TCTCTGTTTATGCAATGTGCTCGAAAGAAAAAAATGTTAAAAATATATCTATAATAATAATTTTTTGTCATTTGTCTTTA
1281 TGTCCAGCTATGAATGTAGATTTTGTGTCCCGACAGCCCTGTTCCTGGTCCAAGTACTTTGTATTGTATACGTGAGTCAT
1361 AATAATAAAAAGAAGAAGAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' guaccAGGGUGGAGGGACGGAc 5'
               ||||||||||||||:| 
Target 5' cacacTCCCACCTCCCTGCTTc 3'
 353 - 374 169.00 -30.90
2 
miRNA  3' guaccaGGGU--GGAGGGACGGAc 5'
                ||||   ||||||||:| 
Target 5' cccctcCCCAGGGCTCCCTGCTTa 3'
 569 - 592 146.00 -21.00
3 
miRNA  3' guaccaGGGUGG--AGGGACGGac 5'
                | |||:  ||||||||  
Target 5' cccacaCACACTTGTCCCTGCCcc 3'
 258 - 281 138.00 -19.90
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN28877271 17 COSMIC
COSN30183035 20 COSMIC
COSN30475167 23 COSMIC
COSN13404745 25 COSMIC
COSN17685096 26 COSMIC
COSN20109650 26 COSMIC
COSN5853124 28 COSMIC
COSN26979230 33 COSMIC
COSN30157612 36 COSMIC
COSN31580694 52 COSMIC
COSN17182712 82 COSMIC
COSN30149865 104 COSMIC
COSN31510392 144 COSMIC
COSN17132534 173 COSMIC
COSN30479389 177 COSMIC
COSN30459807 179 COSMIC
COSN30186913 180 COSMIC
COSN30540568 200 COSMIC
COSN18736841 305 COSMIC
COSN25634736 574 COSMIC
COSN31960797 586 COSMIC
COSN4703064 673 COSMIC
COSN30544260 688 COSMIC
COSN31515235 888 COSMIC
COSN16622007 906 COSMIC
COSN31607884 908 COSMIC
COSN32063712 953 COSMIC
COSN28826882 959 COSMIC
COSN19656442 974 COSMIC
COSN20109654 974 COSMIC
COSN26505421 975 COSMIC
COSN8339970 1041 COSMIC
COSN27388888 1127 COSMIC
COSN31490731 1155 COSMIC
COSN31489634 1208 COSMIC
COSN31570425 1261 COSMIC
COSN31485543 1263 COSMIC
COSN28201835 1306 COSMIC
COSN8586354 1313 COSMIC
COSN20092579 1353 COSMIC
COSN31528062 1369 COSMIC
COSN32056621 1370 COSMIC
COSN31603108 1372 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1450626585 3 dbSNP
rs1419518499 6 dbSNP
rs755196174 7 dbSNP
rs778876885 10 dbSNP
rs1268377040 14 dbSNP
rs747993663 14 dbSNP
rs776089647 14 dbSNP
rs1491480531 15 dbSNP
rs375330102 15 dbSNP
rs534181903 15 dbSNP
rs558229116 15 dbSNP
rs560386503 15 dbSNP
rs758594646 15 dbSNP
rs569341279 16 dbSNP
rs919343727 16 dbSNP
rs758104186 17 dbSNP
rs777820655 18 dbSNP
rs1178593674 19 dbSNP
rs755054190 20 dbSNP
rs905207946 20 dbSNP
rs781620506 21 dbSNP
rs1056660199 22 dbSNP
rs527829808 22 dbSNP
rs748659517 23 dbSNP
rs770479099 23 dbSNP
rs1181637988 24 dbSNP
rs200035305 24 dbSNP
rs201173990 25 dbSNP
rs386763147 25 dbSNP
rs35378573 26 dbSNP
rs398019654 26 dbSNP
rs4142680 26 dbSNP
rs775291126 26 dbSNP
rs1333246117 27 dbSNP
rs1480079268 31 dbSNP
rs926467312 31 dbSNP
rs762289035 35 dbSNP
rs1443968133 38 dbSNP
rs760209116 44 dbSNP
rs370624442 48 dbSNP
rs937881585 49 dbSNP
rs1306233583 50 dbSNP
rs1366339552 63 dbSNP
rs1164577726 65 dbSNP
rs116334238 69 dbSNP
rs915165769 81 dbSNP
rs945049190 82 dbSNP
rs1177249653 88 dbSNP
rs1439168445 97 dbSNP
rs1253775192 104 dbSNP
rs1211699130 108 dbSNP
rs1487653896 125 dbSNP
rs1042460736 126 dbSNP
rs1350172801 126 dbSNP
rs1354094322 127 dbSNP
rs961320268 131 dbSNP
rs550220697 133 dbSNP
rs11170784 153 dbSNP
rs1486048519 161 dbSNP
rs919755329 172 dbSNP
rs530815344 173 dbSNP
rs1387987491 178 dbSNP
rs1388170361 182 dbSNP
rs1360680093 190 dbSNP
rs1292531196 200 dbSNP
rs1420706305 205 dbSNP
rs376723569 207 dbSNP
rs371009456 208 dbSNP
rs1048628606 209 dbSNP
rs1201140215 210 dbSNP
rs544820422 211 dbSNP
rs937994612 213 dbSNP
rs888711594 216 dbSNP
rs1004195294 225 dbSNP
rs1488498508 232 dbSNP
rs1287980272 233 dbSNP
rs776252828 235 dbSNP
rs1352959590 236 dbSNP
rs1256485824 238 dbSNP
rs1234810627 241 dbSNP
rs1452334137 251 dbSNP
rs1300169211 258 dbSNP
rs1056418415 262 dbSNP
rs970752874 263 dbSNP
rs1003577088 268 dbSNP
rs1033764894 269 dbSNP
rs918160473 283 dbSNP
rs945623442 285 dbSNP
rs1464624381 290 dbSNP
rs959179634 310 dbSNP
rs1171475975 312 dbSNP
rs904032490 313 dbSNP
rs146077521 315 dbSNP
rs915134069 330 dbSNP
rs533674404 331 dbSNP
rs977744660 338 dbSNP
rs911553038 339 dbSNP
rs555017651 340 dbSNP
rs1038798176 350 dbSNP
rs1019331945 351 dbSNP
rs1399807831 357 dbSNP
rs961278346 358 dbSNP
rs1336725673 362 dbSNP
rs1406685098 363 dbSNP
rs1394873300 373 dbSNP
rs1402105284 376 dbSNP
rs921710133 383 dbSNP
rs527319199 386 dbSNP
rs1170166312 393 dbSNP
rs1474961695 396 dbSNP
rs1368906016 397 dbSNP
rs1435239844 401 dbSNP
rs1321782552 406 dbSNP
rs1440673907 409 dbSNP
rs1368043679 412 dbSNP
rs932779516 420 dbSNP
rs1244427763 423 dbSNP
rs1458676089 424 dbSNP
rs1026788747 425 dbSNP
rs1283911059 427 dbSNP
rs1213559307 428 dbSNP
rs1356612623 434 dbSNP
rs1286388655 438 dbSNP
rs1243043590 448 dbSNP
rs139313620 473 dbSNP
rs1332587577 480 dbSNP
rs1449121150 487 dbSNP
rs1398117499 490 dbSNP
rs1330757392 497 dbSNP
rs979982860 498 dbSNP
rs1282466530 500 dbSNP
rs888666914 504 dbSNP
rs926696461 505 dbSNP
rs1004879610 518 dbSNP
rs1471663895 520 dbSNP
rs560863597 520 dbSNP
rs1384554231 521 dbSNP
rs959482114 527 dbSNP
rs992082129 534 dbSNP
rs1037321137 535 dbSNP
rs1203195659 537 dbSNP
rs1451873454 548 dbSNP
rs1359112075 551 dbSNP
rs917924581 551 dbSNP
rs945621170 551 dbSNP
rs1043051563 553 dbSNP
rs1209499551 555 dbSNP
rs1383280045 556 dbSNP
rs1443979829 556 dbSNP
rs1249806986 557 dbSNP
rs1279087982 558 dbSNP
rs925583726 559 dbSNP
rs936823164 561 dbSNP
rs1163664728 562 dbSNP
rs537808951 563 dbSNP
rs1186770685 565 dbSNP
rs1421505924 566 dbSNP
rs879062586 568 dbSNP
rs1176166278 571 dbSNP
rs1478046893 573 dbSNP
rs759470150 574 dbSNP
rs12814340 575 dbSNP
rs1196238856 576 dbSNP
rs1490082738 577 dbSNP
rs1317120638 578 dbSNP
rs1458541083 579 dbSNP
rs1410833382 580 dbSNP
rs1457298961 584 dbSNP
rs1284129250 588 dbSNP
rs1219906368 594 dbSNP
rs1369743631 595 dbSNP
rs556188539 601 dbSNP
rs1273306190 605 dbSNP
rs867278617 608 dbSNP
rs1341349904 616 dbSNP
rs1298635884 619 dbSNP
rs906541699 619 dbSNP
rs1003523096 633 dbSNP
rs1403282915 644 dbSNP
rs1401585628 650 dbSNP
rs1358581858 654 dbSNP
rs889539170 659 dbSNP
rs775387857 660 dbSNP
rs1170281727 662 dbSNP
rs959460978 677 dbSNP
rs1334119046 689 dbSNP
rs1040696609 690 dbSNP
rs749725474 698 dbSNP
rs896826415 710 dbSNP
rs1487482062 712 dbSNP
rs1242055656 714 dbSNP
rs1211354173 715 dbSNP
rs1314458925 718 dbSNP
rs1276663319 721 dbSNP
rs994073452 730 dbSNP
rs1277987263 734 dbSNP
rs1328822143 735 dbSNP
rs1229253257 738 dbSNP
rs1010715882 741 dbSNP
rs1027298348 755 dbSNP
rs73313182 757 dbSNP
rs1199768941 758 dbSNP
rs1448739245 785 dbSNP
rs966616358 786 dbSNP
rs1468792468 787 dbSNP
rs1443908685 791 dbSNP
rs1172298403 795 dbSNP
rs144078770 798 dbSNP
rs1250612082 800 dbSNP
rs1182794322 803 dbSNP
rs911850255 808 dbSNP
rs1236203459 809 dbSNP
rs965690791 827 dbSNP
rs974421088 836 dbSNP
rs921659334 837 dbSNP
rs549566934 839 dbSNP
rs930384369 849 dbSNP
rs959415525 850 dbSNP
rs992216667 850 dbSNP
rs1228642168 856 dbSNP
rs1024953541 862 dbSNP
rs1312764112 863 dbSNP
rs984272791 873 dbSNP
rs910033612 879 dbSNP
rs940243917 880 dbSNP
rs1037671693 883 dbSNP
rs1332784441 889 dbSNP
rs1416510770 896 dbSNP
rs1353540152 897 dbSNP
rs1165983149 900 dbSNP
rs906821812 903 dbSNP
rs1306484300 912 dbSNP
rs544850784 913 dbSNP
rs1350274488 917 dbSNP
rs1410616468 918 dbSNP
rs1290480151 920 dbSNP
rs1383947504 932 dbSNP
rs192449987 932 dbSNP
rs1183457085 935 dbSNP
rs1440404250 935 dbSNP
rs1232690048 943 dbSNP
rs1266219157 945 dbSNP
rs1275357017 945 dbSNP
rs1480451761 945 dbSNP
rs1323225234 953 dbSNP
rs934822518 953 dbSNP
rs1289505899 958 dbSNP
rs1491142562 958 dbSNP
rs767808027 958 dbSNP
rs1055035046 959 dbSNP
rs1310881604 959 dbSNP
rs1389147359 959 dbSNP
rs368097239 959 dbSNP
rs771632416 959 dbSNP
rs11444199 960 dbSNP
rs1179786610 960 dbSNP
rs1382668801 960 dbSNP
rs1491484394 960 dbSNP
rs77729302 960 dbSNP
rs878949011 960 dbSNP
rs1273590984 961 dbSNP
rs1491566799 961 dbSNP
rs1193062466 962 dbSNP
rs1483277047 964 dbSNP
rs1206815356 965 dbSNP
rs978148491 965 dbSNP
rs1316366106 966 dbSNP
rs1266387158 967 dbSNP
rs1432075841 968 dbSNP
rs1199032655 970 dbSNP
rs1301548783 971 dbSNP
rs1302964348 971 dbSNP
rs1343243100 971 dbSNP
rs1378863208 972 dbSNP
rs796284080 972 dbSNP
rs1479259029 973 dbSNP
rs1167294695 974 dbSNP
rs77153785 974 dbSNP
rs79679701 975 dbSNP
rs1430848392 976 dbSNP
rs1310063046 979 dbSNP
rs1388919862 983 dbSNP
rs1378344135 989 dbSNP
rs572249872 994 dbSNP
rs925519751 995 dbSNP
rs936981259 995 dbSNP
rs543163396 1000 dbSNP
rs1055066999 1002 dbSNP
rs1263781661 1007 dbSNP
rs1203242316 1012 dbSNP
rs985589772 1013 dbSNP
rs895195429 1024 dbSNP
rs1256137245 1035 dbSNP
rs1324212896 1038 dbSNP
rs1332928872 1048 dbSNP
rs1011414354 1049 dbSNP
rs1219648601 1050 dbSNP
rs1296833140 1055 dbSNP
rs1342579161 1060 dbSNP
rs182733929 1061 dbSNP
rs1040832430 1080 dbSNP
rs1263307170 1081 dbSNP
rs896924736 1088 dbSNP
rs1428890678 1095 dbSNP
rs1468263623 1095 dbSNP
rs1171584645 1100 dbSNP
rs902340354 1107 dbSNP
rs1190742577 1114 dbSNP
rs531616548 1115 dbSNP
rs146523694 1117 dbSNP
rs999388255 1118 dbSNP
rs1018847114 1121 dbSNP
rs1459545127 1123 dbSNP
rs1210073477 1125 dbSNP
rs929618089 1127 dbSNP
rs148698267 1128 dbSNP
rs771617089 1146 dbSNP
rs974368911 1148 dbSNP
rs1315382739 1152 dbSNP
rs1001415308 1163 dbSNP
rs142212620 1165 dbSNP
rs951779584 1167 dbSNP
rs984945372 1170 dbSNP
rs1390156725 1172 dbSNP
rs772973141 1183 dbSNP
rs547667489 1189 dbSNP
rs760080757 1203 dbSNP
rs187964390 1211 dbSNP
rs530198792 1223 dbSNP
rs928195766 1224 dbSNP
rs1178689929 1228 dbSNP
rs1242051239 1228 dbSNP
rs1439232912 1235 dbSNP
rs759918752 1237 dbSNP
rs1270400451 1239 dbSNP
rs879683932 1243 dbSNP
rs767996294 1246 dbSNP
rs1195611637 1248 dbSNP
rs1357426366 1251 dbSNP
rs1433049633 1254 dbSNP
rs1025468989 1255 dbSNP
rs548679363 1257 dbSNP
rs1310143881 1261 dbSNP
rs1365920490 1268 dbSNP
rs1334222354 1270 dbSNP
rs567307738 1273 dbSNP
rs1328366506 1280 dbSNP
rs966854568 1282 dbSNP
rs537540945 1287 dbSNP
rs1055012782 1291 dbSNP
rs1032348527 1293 dbSNP
rs958240333 1297 dbSNP
rs985720701 1298 dbSNP
rs1470852621 1300 dbSNP
rs895140016 1306 dbSNP
rs556167316 1312 dbSNP
rs61921780 1313 dbSNP
rs1451821941 1318 dbSNP
rs1326439708 1331 dbSNP
rs976946833 1341 dbSNP
rs1359410987 1343 dbSNP
rs1207620342 1345 dbSNP
rs533513524 1352 dbSNP
rs1317798967 1353 dbSNP
rs765174294 1353 dbSNP
rs1191070921 1354 dbSNP
rs1437529214 1364 dbSNP
rs1347597039 1370 dbSNP
rs929781220 1375 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Disease 3224.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM714644. RNA binding protein: AGO2. Condition:completeT1 "PAR-CLIP data was present in GSM714645. RNA binding protein: AGO2. Condition:completeT1 ...

- Kishore S; Jaskiewicz L; Burger L; Hausser et al., 2011, Nature methods.

Article - Kishore S; Jaskiewicz L; Burger L; Hausser et al.
- Nature methods, 2011
Cross-linking and immunoprecipitation (CLIP) is increasingly used to map transcriptome-wide binding sites of RNA-binding proteins. We developed a method for CLIP data analysis, and applied it to compare CLIP with photoactivatable ribonucleoside-enhanced CLIP (PAR-CLIP) and to uncover how differences in cross-linking and ribonuclease digestion affect the identified sites. We found only small differences in accuracies of these methods in identifying binding sites of HuR, which binds low-complexity sequences, and Argonaute 2, which has a complex binding specificity. We found that cross-link-induced mutations led to single-nucleotide resolution for both PAR-CLIP and CLIP. Our results confirm the expectation from original CLIP publications that RNA-binding proteins do not protect their binding sites sufficiently under the denaturing conditions used during the CLIP procedure, and we show that extensive digestion with sequence-specific RNases strongly biases the recovered binding sites. This bias can be substantially reduced by milder nuclease digestion conditions.
LinkOut: [PMID: 21572407]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions LCL-BACD1 , LCL-BACD3
Disease MIMAT0027516
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM1020024. RNA binding protein: AGO2. Condition:EBV B95-8-infected "PAR-CLIP data was present in GSM1020025. RNA binding protein: AGO2. Condition:EBV B95-8-infected ...

- Skalsky RL; Corcoran DL; Gottwein E; Frank et al., 2012, PLoS pathogens.

Article - Skalsky RL; Corcoran DL; Gottwein E; Frank et al.
- PLoS pathogens, 2012
Epstein-Barr virus (EBV) is a ubiquitous human herpesvirus linked to a number of B cell cancers and lymphoproliferative disorders. During latent infection, EBV expresses 25 viral pre-microRNAs (miRNAs) and induces the expression of specific host miRNAs, such as miR-155 and miR-21, which potentially play a role in viral oncogenesis. To date, only a limited number of EBV miRNA targets have been identified; thus, the role of EBV miRNAs in viral pathogenesis and/or lymphomagenesis is not well defined. Here, we used photoactivatable ribonucleoside-enhanced crosslinking and immunoprecipitation (PAR-CLIP) combined with deep sequencing and computational analysis to comprehensively examine the viral and cellular miRNA targetome in EBV strain B95-8-infected lymphoblastoid cell lines (LCLs). We identified 7,827 miRNA-interaction sites in 3,492 cellular 3'UTRs. 531 of these sites contained seed matches to viral miRNAs. 24 PAR-CLIP-identified miRNA:3'UTR interactions were confirmed by reporter assays. Our results reveal that EBV miRNAs predominantly target cellular transcripts during latent infection, thereby manipulating the host environment. Furthermore, targets of EBV miRNAs are involved in multiple cellular processes that are directly relevant to viral infection, including innate immunity, cell survival, and cell proliferation. Finally, we present evidence that myc-regulated host miRNAs from the miR-17/92 cluster can regulate latent viral gene expression. This comprehensive survey of the miRNA targetome in EBV-infected B cells represents a key step towards defining the functions of EBV-encoded miRNAs, and potentially, identifying novel therapeutic targets for EBV-associated malignancies.
LinkOut: [PMID: 22291592]
Experimental Support 3 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Disease 3224.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM1065670. RNA binding protein: AGO2. Condition:4-thiouridine ...

- Memczak S; Jens M; Elefsinioti A; Torti F; et al., 2013, Nature.

Article - Memczak S; Jens M; Elefsinioti A; Torti F; et al.
- Nature, 2013
Circular RNAs (circRNAs) in animals are an enigmatic class of RNA with unknown function. To explore circRNAs systematically, we sequenced and computationally analysed human, mouse and nematode RNA. We detected thousands of well-expressed, stable circRNAs, often showing tissue/developmental-stage-specific expression. Sequence analysis indicated important regulatory functions for circRNAs. We found that a human circRNA, antisense to the cerebellar degeneration-related protein 1 transcript (CDR1as), is densely bound by microRNA (miRNA) effector complexes and harbours 63 conserved binding sites for the ancient miRNA miR-7. Further analyses indicated that CDR1as functions to bind miR-7 in neuronal tissues. Human CDR1as expression in zebrafish impaired midbrain development, similar to knocking down miR-7, suggesting that CDR1as is a miRNA antagonist with a miRNA-binding capacity ten times higher than any other known transcript. Together, our data provide evidence that circRNAs form a large class of post-transcriptional regulators. Numerous circRNAs form by head-to-tail splicing of exons, suggesting previously unrecognized regulatory potential of coding sequences.
LinkOut: [PMID: 23446348]
CLIP-seq Support 1 for dataset GSM714644
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / completeT1, repA
Location of target site ENST00000040584.4 | 3UTR | UUUGUUGCUGCUUAUUUCACUAAGAAAACCCAACAACUGAGACUGCCUAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 21572407 / GSE28865
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM714645
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / completeT1, repB
Location of target site ENST00000040584.4 | 3UTR | AAAACCCAACAACUGAGACUGCCUAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 21572407 / GSE28865
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM1065670
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / 4-thiouridine, 3_ML_LG
Location of target site ENST00000040584.4 | 3UTR | AAAACCCAACAACUGAGACUGCCUAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23446348 / GSE43573
CLIP-seq Viewer Link
CLIP-seq Support 4 for dataset GSM1020024
Method / RBP PAR-CLIP / AGO2
Cell line / Condition LCL-BACD1 / EBV B95-8-infected, 4-thiouridine, RNase T1
Location of target site ENST00000040584.4 | 3UTR | GCCUAGCCCGCCGGUC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 22291592 / GSE41437
CLIP-seq Viewer Link
CLIP-seq Support 5 for dataset GSM1020025
Method / RBP PAR-CLIP / AGO2
Cell line / Condition LCL-BACD3 / EBV B95-8-infected, 4-thiouridine, RNase T1
Location of target site ENST00000040584.4 | 3UTR | GCCUAGCCCGCCGGUC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 22291592 / GSE41437
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
481 hsa-miR-6808-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT058861 VANGL1 VANGL planar cell polarity protein 1 2 6
MIRT065801 HOXC8 homeobox C8 2 6
MIRT108715 XIAP X-linked inhibitor of apoptosis 2 2
MIRT113314 SMARCD1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1 2 2
MIRT129749 AGTRAP angiotensin II receptor associated protein 2 2
MIRT140199 CHAC1 ChaC glutathione specific gamma-glutamylcyclotransferase 1 2 2
MIRT166797 PAPD7 poly(A) RNA polymerase D7, non-canonical 2 4
MIRT180260 PRRG4 proline rich and Gla domain 4 2 2
MIRT307008 TGFBR2 transforming growth factor beta receptor 2 2 2
MIRT325577 HIATL1 major facilitator superfamily domain containing 14B 2 4
MIRT370131 TRIB3 tribbles pseudokinase 3 2 2
MIRT370517 ZNRF3 zinc and ring finger 3 2 2
MIRT386083 ZNF609 zinc finger protein 609 2 2
MIRT395059 TNFAIP2 TNF alpha induced protein 2 2 2
MIRT406920 PTBP1 polypyrimidine tract binding protein 1 2 2
MIRT443500 MXI1 MAX interactor 1, dimerization protein 2 4
MIRT443532 ACAP2 ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 2 2
MIRT444630 GSPT1 G1 to S phase transition 1 2 2
MIRT446287 C17orf102 chromosome 17 open reading frame 102 2 2
MIRT447170 MFSD8 major facilitator superfamily domain containing 8 2 2
MIRT447914 SLC35E2 solute carrier family 35 member E2 2 2
MIRT448204 B4GALT7 beta-1,4-galactosyltransferase 7 2 4
MIRT451117 RPS19 ribosomal protein S19 2 2
MIRT451467 HSD11B1L hydroxysteroid 11-beta dehydrogenase 1 like 2 2
MIRT451511 ALOX15 arachidonate 15-lipoxygenase 2 2
MIRT452069 ZNF585B zinc finger protein 585B 2 10
MIRT452224 HAVCR1 hepatitis A virus cellular receptor 1 2 6
MIRT452586 ZFP69B ZFP69 zinc finger protein B 2 2
MIRT452643 PCCB propionyl-CoA carboxylase beta subunit 2 2
MIRT452730 AGAP9 ArfGAP with GTPase domain, ankyrin repeat and PH domain 9 2 4
MIRT452745 PTGES3L prostaglandin E synthase 3 like 2 2
MIRT452772 TCEA3 transcription elongation factor A3 2 4
MIRT452836 FAM131B family with sequence similarity 131 member B 2 2
MIRT452875 LAX1 lymphocyte transmembrane adaptor 1 2 2
MIRT452884 PRSS45 protease, serine 45 2 2
MIRT452973 ZNF844 zinc finger protein 844 2 6
MIRT453031 ZNF527 zinc finger protein 527 2 4
MIRT453175 CNOT4 CCR4-NOT transcription complex subunit 4 2 6
MIRT453436 GLG1 golgi glycoprotein 1 2 2
MIRT453613 ZNF557 zinc finger protein 557 2 2
MIRT453714 TBX20 T-box 20 2 2
MIRT453916 GABRR2 gamma-aminobutyric acid type A receptor rho2 subunit 2 2
MIRT453974 ATP13A4 ATPase 13A4 2 6
MIRT454075 SLC35E3 solute carrier family 35 member E3 2 2
MIRT454256 CCDC125 coiled-coil domain containing 125 2 2
MIRT454994 RECK reversion inducing cysteine rich protein with kazal motifs 2 2
MIRT455150 TBC1D25 TBC1 domain family member 25 2 2
MIRT455489 NPY4R neuropeptide Y receptor Y4 2 2
MIRT455706 ZMYM1 zinc finger MYM-type containing 1 2 2
MIRT455878 SLC35C2 solute carrier family 35 member C2 2 2
MIRT455954 CYP4A22 cytochrome P450 family 4 subfamily A member 22 2 2
MIRT455978 BCAS4 breast carcinoma amplified sequence 4 2 4
MIRT456220 LIX1L limb and CNS expressed 1 like 2 6
MIRT456241 LHPP phospholysine phosphohistidine inorganic pyrophosphate phosphatase 2 6
MIRT456283 HRNR hornerin 2 2
MIRT456743 TMEM239 transmembrane protein 239 2 2
MIRT456927 DDA1 DET1 and DDB1 associated 1 2 2
MIRT457005 ZNF669 zinc finger protein 669 2 4
MIRT457149 MXRA7 matrix remodeling associated 7 2 4
MIRT457348 HSD3B7 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7 2 2
MIRT457478 SLC35F6 solute carrier family 35 member F6 2 2
MIRT457553 ZC3H6 zinc finger CCCH-type containing 6 2 2
MIRT457752 NCR3LG1 natural killer cell cytotoxicity receptor 3 ligand 1 2 2
MIRT457990 APAF1 apoptotic peptidase activating factor 1 2 4
MIRT458405 ABCF1 ATP binding cassette subfamily F member 1 2 4
MIRT458468 SNX22 sorting nexin 22 2 6
MIRT458518 GSG2 histone H3 associated protein kinase 2 6
MIRT458564 C10orf71 chromosome 10 open reading frame 71 2 2
MIRT458654 SGPP2 sphingosine-1-phosphate phosphatase 2 2 2
MIRT458753 CES2 carboxylesterase 2 2 2
MIRT458788 ZNF786 zinc finger protein 786 2 2
MIRT458805 CYP8B1 cytochrome P450 family 8 subfamily B member 1 2 2
MIRT458902 PFAS phosphoribosylformylglycinamidine synthase 2 2
MIRT458959 SAMD4B sterile alpha motif domain containing 4B 2 2
MIRT459002 KIAA1551 KIAA1551 2 2
MIRT459109 CYP4A11 cytochrome P450 family 4 subfamily A member 11 2 2
MIRT459333 HAVCR2 hepatitis A virus cellular receptor 2 2 2
MIRT459403 MPLKIP M-phase specific PLK1 interacting protein 2 2
MIRT459557 BTD biotinidase 2 4
MIRT460252 IL17RB interleukin 17 receptor B 2 2
MIRT460369 TXNDC16 thioredoxin domain containing 16 2 4
MIRT460519 SDE2 SDE2 telomere maintenance homolog 2 2
MIRT460707 RNF157 ring finger protein 157 2 2
MIRT460788 VPS37B VPS37B, ESCRT-I subunit 2 2
MIRT460806 VPS33A VPS33A, CORVET/HOPS core subunit 2 2
MIRT460845 EGF epidermal growth factor 2 4
MIRT460951 NOA1 nitric oxide associated 1 2 2
MIRT461017 SYT7 synaptotagmin 7 2 2
MIRT461132 RAB36 RAB36, member RAS oncogene family 2 4
MIRT461215 TIPIN TIMELESS interacting protein 2 2
MIRT461408 SLFN12L schlafen family member 12 like 2 8
MIRT461565 SCO1 SCO1, cytochrome c oxidase assembly protein 2 4
MIRT461829 SNAP23 synaptosome associated protein 23 2 2
MIRT461869 ZNF317 zinc finger protein 317 2 2
MIRT462088 MSANTD2 Myb/SANT DNA binding domain containing 2 2 2
MIRT462219 MLH1 mutL homolog 1 2 2
MIRT462438 GTPBP10 GTP binding protein 10 2 4
MIRT462512 MTFMT mitochondrial methionyl-tRNA formyltransferase 2 8
MIRT462542 PLLP plasmolipin 2 4
MIRT462895 ZSCAN29 zinc finger and SCAN domain containing 29 2 4
MIRT462975 ZNF788 zinc finger family member 788 2 2
MIRT463079 ZNF639 zinc finger protein 639 2 4
MIRT463905 WNT7B Wnt family member 7B 2 2
MIRT464126 VPS35 VPS35, retromer complex component 2 2
MIRT464835 UBE2B ubiquitin conjugating enzyme E2 B 2 2
MIRT465532 PRICKLE4 prickle planar cell polarity protein 4 2 2
MIRT465586 TNRC6B trinucleotide repeat containing 6B 2 4
MIRT466097 TMEM184C transmembrane protein 184C 2 2
MIRT466220 TMED10 transmembrane p24 trafficking protein 10 2 2
MIRT466696 TAF13 TATA-box binding protein associated factor 13 2 4
MIRT467019 SSBP2 single stranded DNA binding protein 2 2 4
MIRT467261 SPPL2A signal peptide peptidase like 2A 2 2
MIRT467760 SLC35F1 solute carrier family 35 member F1 2 4
MIRT469015 RNF41 ring finger protein 41 2 2
MIRT469071 RNF20 ring finger protein 20 2 2
MIRT469582 RARA retinoic acid receptor alpha 2 2
MIRT471070 PIM2 Pim-2 proto-oncogene, serine/threonine kinase 2 2
MIRT471480 PDE7B phosphodiesterase 7B 2 2
MIRT471653 PANK2 pantothenate kinase 2 2 4
MIRT471852 NUFIP2 NUFIP2, FMR1 interacting protein 2 2 2
MIRT472327 NF2 neurofibromin 2 2 2
MIRT472838 MTMR10 myotubularin related protein 10 2 4
MIRT473058 MORN4 MORN repeat containing 4 2 6
MIRT473119 MLXIP MLX interacting protein 2 2
MIRT474187 LETMD1 LETM1 domain containing 1 2 2
MIRT474373 KLLN killin, p53-regulated DNA replication inhibitor 2 6
MIRT474445 KLHL18 kelch like family member 18 2 6
MIRT474624 KLF2 Kruppel like factor 2 2 4
MIRT474892 KCTD5 potassium channel tetramerization domain containing 5 2 2
MIRT475293 TOR1AIP2 torsin 1A interacting protein 2 2 2
MIRT475404 ICMT isoprenylcysteine carboxyl methyltransferase 2 4
MIRT475691 HHIPL1 HHIP like 1 2 2
MIRT476416 GDE1 glycerophosphodiester phosphodiesterase 1 2 8
MIRT476811 FNDC3B fibronectin type III domain containing 3B 2 2
MIRT477083 FAM208A family with sequence similarity 208 member A 2 6
MIRT477654 EFNA1 ephrin A1 2 2
MIRT478232 DDX52 DExD-box helicase 52 2 2
MIRT478491 CYP20A1 cytochrome P450 family 20 subfamily A member 1 2 2
MIRT478762 CS citrate synthase 2 2
MIRT478822 CRTAP cartilage associated protein 2 2
MIRT479204 CLCN5 chloride voltage-gated channel 5 2 6
MIRT479306 CFL2 cofilin 2 2 2
MIRT479922 CCDC117 coiled-coil domain containing 117 2 6
MIRT480237 C9orf41 carnosine N-methyltransferase 1 2 2
MIRT480361 C5orf24 chromosome 5 open reading frame 24 2 2
MIRT480736 BPTF bromodomain PHD finger transcription factor 2 2
MIRT481074 B4GALT1 beta-1,4-galactosyltransferase 1 2 2
MIRT481104 B3GALNT2 beta-1,3-N-acetylgalactosaminyltransferase 2 2 2
MIRT481272 ATXN7L3 ataxin 7 like 3 2 2
MIRT481438 ASB6 ankyrin repeat and SOCS box containing 6 2 2
MIRT481577 ARIH2 ariadne RBR E3 ubiquitin protein ligase 2 2 2
MIRT481625 ARHGAP1 Rho GTPase activating protein 1 2 2
MIRT482263 AGO3 argonaute 3, RISC catalytic component 2 2
MIRT482380 AEN apoptosis enhancing nuclease 2 2
MIRT486076 ARPP19 cAMP regulated phosphoprotein 19 2 4
MIRT486947 DTX2 deltex E3 ubiquitin ligase 2 2 2
MIRT487274 CCNF cyclin F 2 2
MIRT487360 PHF15 jade family PHD finger 2 1 1
MIRT487471 ANKRD42 ankyrin repeat domain 42 2 2
MIRT487532 GXYLT2 glucoside xylosyltransferase 2 2 4
MIRT487975 IQSEC2 IQ motif and Sec7 domain 2 2 2
MIRT489048 PRPF4B pre-mRNA processing factor 4B 2 2
MIRT489071 STARD3 StAR related lipid transfer domain containing 3 2 2
MIRT489725 CALML3 calmodulin like 3 2 2
MIRT490849 ADD2 adducin 2 2 2
MIRT491851 ZBTB7A zinc finger and BTB domain containing 7A 2 2
MIRT492643 PLXNA1 plexin A1 2 2
MIRT492696 PHYHIP phytanoyl-CoA 2-hydroxylase interacting protein 2 2
MIRT495462 PNMAL2 paraneoplastic Ma antigen family member 8B 2 2
MIRT495494 VTI1B vesicle transport through interaction with t-SNAREs 1B 2 2
MIRT495729 AGO1 argonaute 1, RISC catalytic component 2 2
MIRT495775 ZNF546 zinc finger protein 546 2 4
MIRT495807 MRPL12 mitochondrial ribosomal protein L12 2 2
MIRT495827 TMEM151A transmembrane protein 151A 2 2
MIRT496079 ATP1B4 ATPase Na+/K+ transporting family member beta 4 2 4
MIRT496103 SNX17 sorting nexin 17 2 2
MIRT496140 RBL1 RB transcriptional corepressor like 1 2 2
MIRT496182 TRIM73 tripartite motif containing 73 2 2
MIRT496236 TRIM74 tripartite motif containing 74 2 2
MIRT496265 SHROOM2 shroom family member 2 2 2
MIRT496280 SLC2A13 solute carrier family 2 member 13 2 2
MIRT496292 BAZ2A bromodomain adjacent to zinc finger domain 2A 2 2
MIRT496500 MAST3 microtubule associated serine/threonine kinase 3 2 2
MIRT496545 EBI3 Epstein-Barr virus induced 3 2 2
MIRT496706 TRIM39 tripartite motif containing 39 2 2
MIRT496799 BTRC beta-transducin repeat containing E3 ubiquitin protein ligase 2 2
MIRT498685 SERPINH1 serpin family H member 1 2 2
MIRT498742 SNTN sentan, cilia apical structure protein 2 6
MIRT500560 XBP1P1 X-box binding protein 1 pseudogene 1 2 8
MIRT503041 CAMSAP2 calmodulin regulated spectrin associated protein family member 2 2 2
MIRT503438 SLC25A45 solute carrier family 25 member 45 2 6
MIRT507273 FERMT2 fermitin family member 2 2 2
MIRT507345 FAM168A family with sequence similarity 168 member A 2 2
MIRT507970 BCL2L13 BCL2 like 13 2 4
MIRT508613 IRAK4 interleukin 1 receptor associated kinase 4 2 6
MIRT508905 PTPLB 3-hydroxyacyl-CoA dehydratase 2 1 1
MIRT510122 IRAK3 interleukin 1 receptor associated kinase 3 2 8
MIRT510471 ZDHHC18 zinc finger DHHC-type containing 18 2 2
MIRT512944 MAP3K7 mitogen-activated protein kinase kinase kinase 7 2 4
MIRT514159 TMEM145 transmembrane protein 145 2 4
MIRT514202 PGPEP1 pyroglutamyl-peptidase I 2 4
MIRT517228 PRIM1 DNA primase subunit 1 2 4
MIRT517484 PEX26 peroxisomal biogenesis factor 26 2 2
MIRT517984 DSCR3 DSCR3 arrestin fold containing 2 2
MIRT518736 ABCG8 ATP binding cassette subfamily G member 8 2 2
MIRT518912 CDC14B cell division cycle 14B 2 2
MIRT520057 YIPF4 Yip1 domain family member 4 2 6
MIRT524625 C7orf73 short transmembrane mitochondrial protein 1 2 2
MIRT524889 ARHGAP11A Rho GTPase activating protein 11A 2 4
MIRT529054 CDK18 cyclin dependent kinase 18 2 2
MIRT531311 GPR26 G protein-coupled receptor 26 2 2
MIRT533554 TPM4 tropomyosin 4 2 2
MIRT534864 RAB15 RAB15, member RAS oncogene family 2 4
MIRT541073 SENP5 SUMO1/sentrin specific peptidase 5 2 2
MIRT544171 HEYL hes related family bHLH transcription factor with YRPW motif-like 2 2
MIRT547847 IGF1R insulin like growth factor 1 receptor 2 2
MIRT548044 GOLIM4 golgi integral membrane protein 4 2 2
MIRT550431 ORC4 origin recognition complex subunit 4 2 2
MIRT550586 SLC2A5 solute carrier family 2 member 5 2 2
MIRT550602 CBY3 chibby family member 3 2 2
MIRT550993 RBM38 RNA binding motif protein 38 2 2
MIRT551343 MRE11A MRE11 homolog, double strand break repair nuclease 2 2
MIRT551376 EPM2AIP1 EPM2A interacting protein 1 2 2
MIRT551399 MRI1 methylthioribose-1-phosphate isomerase 1 2 4
MIRT551594 HDGFRP2 HDGF like 2 2 2
MIRT553095 UBXN2A UBX domain protein 2A 2 4
MIRT554232 SLC17A5 solute carrier family 17 member 5 2 2
MIRT555407 PPM1L protein phosphatase, Mg2+/Mn2+ dependent 1L 2 2
MIRT557317 HIF1A hypoxia inducible factor 1 alpha subunit 2 2
MIRT559321 ATXN1 ataxin 1 2 2
MIRT559663 AHCYL2 adenosylhomocysteinase like 2 2 2
MIRT562322 G3BP1 G3BP stress granule assembly factor 1 2 2
MIRT563670 SMC4 structural maintenance of chromosomes 4 2 2
MIRT565907 SCAMP2 secretory carrier membrane protein 2 2 2
MIRT569838 SOX11 SRY-box 11 2 2
MIRT570250 CPNE5 copine 5 2 2
MIRT575575 Cd99 CD99 antigen 2 2
MIRT608281 NOP14 NOP14 nucleolar protein 2 2
MIRT610868 ARSA arylsulfatase A 2 2
MIRT614145 THAP1 THAP domain containing 1 2 6
MIRT614602 IRF2BPL interferon regulatory factor 2 binding protein like 2 2
MIRT615239 BROX BRO1 domain and CAAX motif containing 2 2
MIRT617433 ANP32E acidic nuclear phosphoprotein 32 family member E 2 4
MIRT618182 ZNF681 zinc finger protein 681 2 4
MIRT618886 MBL2 mannose binding lectin 2 2 2
MIRT618988 MRPS16 mitochondrial ribosomal protein S16 2 2
MIRT619200 SLC16A4 solute carrier family 16 member 4 2 2
MIRT620327 AQP6 aquaporin 6 2 2
MIRT620461 CENPN centromere protein N 2 2
MIRT621654 UBXN2B UBX domain protein 2B 2 2
MIRT622826 PGAM5 PGAM family member 5, mitochondrial serine/threonine protein phosphatase 2 4
MIRT623364 LZIC leucine zipper and CTNNBIP1 domain containing 2 2
MIRT624934 FBXW2 F-box and WD repeat domain containing 2 2 2
MIRT624990 ZNF665 zinc finger protein 665 2 4
MIRT625501 SMAD9 SMAD family member 9 2 2
MIRT625603 KLHL23 kelch like family member 23 2 2
MIRT625672 C2orf48 chromosome 2 open reading frame 48 2 2
MIRT625892 INADL PATJ, crumbs cell polarity complex component 2 2
MIRT626242 ZNF749 zinc finger protein 749 2 2
MIRT626635 SLC30A6 solute carrier family 30 member 6 2 2
MIRT626998 LINC00598 long intergenic non-protein coding RNA 598 2 2
MIRT627472 STX7 syntaxin 7 2 2
MIRT627686 RPL28 ribosomal protein L28 2 2
MIRT627902 OLFML2A olfactomedin like 2A 2 2
MIRT627992 NDRG3 NDRG family member 3 2 2
MIRT628328 CLPB ClpB homolog, mitochondrial AAA ATPase chaperonin 2 2
MIRT628349 CCDC68 coiled-coil domain containing 68 2 2
MIRT630198 TLN1 talin 1 2 2
MIRT631961 CDKAL1 CDK5 regulatory subunit associated protein 1 like 1 2 4
MIRT633402 FBXW8 F-box and WD repeat domain containing 8 2 2
MIRT633844 WHAMM WAS protein homolog associated with actin, golgi membranes and microtubules 2 2
MIRT635393 NHLRC2 NHL repeat containing 2 2 2
MIRT635807 DNAJC10 DnaJ heat shock protein family (Hsp40) member C10 2 2
MIRT636374 OGFRL1 opioid growth factor receptor like 1 2 2
MIRT638671 GGCX gamma-glutamyl carboxylase 2 2
MIRT639200 TRAPPC2 trafficking protein particle complex 2 2 2
MIRT639603 CD3EAP CD3e molecule associated protein 2 2
MIRT639684 PPEF2 protein phosphatase with EF-hand domain 2 2 6
MIRT642237 RABAC1 Rab acceptor 1 2 2
MIRT642381 ZNF581 zinc finger protein 581 2 2
MIRT645778 RAB3B RAB3B, member RAS oncogene family 2 2
MIRT647078 BRIX1 BRX1, biogenesis of ribosomes 2 4
MIRT647329 RPH3AL rabphilin 3A like (without C2 domains) 2 2
MIRT649010 MRPL49 mitochondrial ribosomal protein L49 2 2
MIRT650461 ZNF141 zinc finger protein 141 2 2
MIRT650537 CCDC77 coiled-coil domain containing 77 2 4
MIRT651002 ZNF770 zinc finger protein 770 2 2
MIRT651749 VEGFB vascular endothelial growth factor B 2 2
MIRT655737 NRXN3 neurexin 3 2 2
MIRT657580 GRSF1 G-rich RNA sequence binding factor 1 2 2
MIRT658636 ENAH ENAH, actin regulator 2 2
MIRT659824 CASP16 caspase 16, pseudogene 2 2
MIRT660479 ARSK arylsulfatase family member K 2 2
MIRT661146 ZNF43 zinc finger protein 43 2 2
MIRT661205 MPPE1 metallophosphoesterase 1 2 2
MIRT661440 MANSC1 MANSC domain containing 1 2 2
MIRT661553 ZNF674 zinc finger protein 674 2 4
MIRT661687 ZNF623 zinc finger protein 623 2 2
MIRT661812 NUP85 nucleoporin 85 2 2
MIRT661865 ZNF766 zinc finger protein 766 2 2
MIRT662142 ZC3H8 zinc finger CCCH-type containing 8 2 2
MIRT662295 SLC29A4 solute carrier family 29 member 4 2 2
MIRT662519 ANGPT4 angiopoietin 4 2 2
MIRT662720 C10orf111 chromosome 10 open reading frame 111 2 4
MIRT662838 LY6G5B lymphocyte antigen 6 family member G5B 2 2
MIRT662894 PCDHA6 protocadherin alpha 6 2 2
MIRT663007 TMEM59 transmembrane protein 59 2 2
MIRT663247 MPHOSPH8 M-phase phosphoprotein 8 2 2
MIRT663432 ZNF607 zinc finger protein 607 2 2
MIRT663714 ABHD17B abhydrolase domain containing 17B 2 2
MIRT663837 AGBL5 ATP/GTP binding protein like 5 2 4
MIRT663873 MUC20 mucin 20, cell surface associated 2 2
MIRT664271 NMUR1 neuromedin U receptor 1 2 2
MIRT664853 HUS1 HUS1 checkpoint clamp component 2 2
MIRT664948 CARD6 caspase recruitment domain family member 6 2 4
MIRT665519 UTP15 UTP15, small subunit processome component 2 2
MIRT665652 TRPM7 transient receptor potential cation channel subfamily M member 7 2 2
MIRT665672 TRAF1 TNF receptor associated factor 1 2 2
MIRT665697 TNPO3 transportin 3 2 2
MIRT665854 TIAL1 TIA1 cytotoxic granule associated RNA binding protein like 1 2 2
MIRT665944 TBC1D19 TBC1 domain family member 19 2 4
MIRT666009 SYNJ2BP synaptojanin 2 binding protein 2 2
MIRT666110 SSR1 signal sequence receptor subunit 1 2 2
MIRT666176 SNX27 sorting nexin family member 27 2 4
MIRT666377 SHOX short stature homeobox 2 2
MIRT667008 PDPN podoplanin 2 4
MIRT667189 NR2F6 nuclear receptor subfamily 2 group F member 6 2 4
MIRT667608 LIPC lipase C, hepatic type 2 2
MIRT667832 IRGQ immunity related GTPase Q 2 2
MIRT667866 IPCEF1 interaction protein for cytohesin exchange factors 1 2 2
MIRT668300 FOSL2 FOS like 2, AP-1 transcription factor subunit 2 4
MIRT668584 ELMSAN1 ELM2 and Myb/SANT domain containing 1 2 4
MIRT669016 CHORDC1 cysteine and histidine rich domain containing 1 2 2
MIRT669107 CDK19 cyclin dependent kinase 19 2 2
MIRT670077 ZNF783 zinc finger family member 783 2 2
MIRT670968 UGGT1 UDP-glucose glycoprotein glucosyltransferase 1 2 4
MIRT671199 ZNF891 zinc finger protein 891 2 2
MIRT671414 ERCC6L2 ERCC excision repair 6 like 2 2 2
MIRT671750 ZNF451 zinc finger protein 451 2 2
MIRT672051 SMTNL2 smoothelin like 2 2 2
MIRT672589 RNF24 ring finger protein 24 2 2
MIRT673456 ZNF583 zinc finger protein 583 2 2
MIRT673921 DCTN6 dynactin subunit 6 2 2
MIRT673956 ZNF500 zinc finger protein 500 2 2
MIRT674171 BLOC1S3 biogenesis of lysosomal organelles complex 1 subunit 3 2 2
MIRT674210 FUT2 fucosyltransferase 2 2 2
MIRT674691 PLCE1 phospholipase C epsilon 1 2 2
MIRT675251 MAK male germ cell associated kinase 2 2
MIRT675365 KLHL26 kelch like family member 26 2 2
MIRT676016 CRKL CRK like proto-oncogene, adaptor protein 2 2
MIRT678297 PTRH2 peptidyl-tRNA hydrolase 2 2 2
MIRT680264 NDUFA7 NADH:ubiquinone oxidoreductase subunit A7 2 2
MIRT680944 EVC EvC ciliary complex subunit 1 2 2
MIRT680968 SLC15A1 solute carrier family 15 member 1 2 4
MIRT681069 PAQR7 progestin and adipoQ receptor family member 7 2 2
MIRT681213 ZNF638 zinc finger protein 638 2 2
MIRT681578 ABHD15 abhydrolase domain containing 15 2 2
MIRT681601 SNRPD1 small nuclear ribonucleoprotein D1 polypeptide 2 2
MIRT681916 SLC11A2 solute carrier family 11 member 2 2 2
MIRT682041 AGXT2 alanine--glyoxylate aminotransferase 2 2 4
MIRT682344 PPP1R15B protein phosphatase 1 regulatory subunit 15B 2 4
MIRT682669 CASP8 caspase 8 2 2
MIRT683287 ZNF99 zinc finger protein 99 2 2
MIRT683363 SCARF1 scavenger receptor class F member 1 2 2
MIRT683457 ACOT2 acyl-CoA thioesterase 2 2 2
MIRT683600 GSTCD glutathione S-transferase C-terminal domain containing 2 2
MIRT683665 ZNF695 zinc finger protein 695 2 2
MIRT683740 EIF3L eukaryotic translation initiation factor 3 subunit L 2 2
MIRT683774 CPE carboxypeptidase E 2 2
MIRT683811 NOTO notochord homeobox 2 2
MIRT684466 MFSD4 major facilitator superfamily domain containing 4A 2 2
MIRT684529 C1orf174 chromosome 1 open reading frame 174 2 2
MIRT684989 MINOS1 mitochondrial inner membrane organizing system 1 2 2
MIRT685016 CXorf56 chromosome X open reading frame 56 2 2
MIRT685119 DTD2 D-tyrosyl-tRNA deacylase 2 (putative) 2 2
MIRT685481 CACNG8 calcium voltage-gated channel auxiliary subunit gamma 8 2 2
MIRT686014 NEK4 NIMA related kinase 4 2 2
MIRT686036 UMPS uridine monophosphate synthetase 2 2
MIRT686563 TPM3 tropomyosin 3 2 2
MIRT686734 TANGO2 transport and golgi organization 2 homolog 2 2
MIRT686970 SFT2D2 SFT2 domain containing 2 2 2
MIRT687291 PARP2 poly(ADP-ribose) polymerase 2 2 2
MIRT687340 OSBPL2 oxysterol binding protein like 2 2 2
MIRT687558 MLEC malectin 2 2
MIRT687762 KIAA1328 KIAA1328 2 2
MIRT688089 GLUL glutamate-ammonia ligase 2 2
MIRT688605 CYCS cytochrome c, somatic 2 2
MIRT688925 C11orf84 chromosome 11 open reading frame 84 2 2
MIRT689289 C5AR2 complement component 5a receptor 2 2 2
MIRT689446 CYB561 cytochrome b561 2 2
MIRT689559 XPO6 exportin 6 2 2
MIRT690055 C6orf141 chromosome 6 open reading frame 141 2 2
MIRT690208 C5orf45 MRN complex interacting protein 2 2
MIRT690275 CAMLG calcium modulating ligand 2 2
MIRT690335 MRPS30 mitochondrial ribosomal protein S30 2 2
MIRT690530 ZNF566 zinc finger protein 566 2 2
MIRT690585 MICA MHC class I polypeptide-related sequence A 2 2
MIRT690877 PLEKHG2 pleckstrin homology and RhoGEF domain containing G2 2 2
MIRT691162 APOL6 apolipoprotein L6 2 2
MIRT691292 CENPM centromere protein M 2 2
MIRT691768 BCL2L15 BCL2 like 15 2 2
MIRT691786 SLC24A4 solute carrier family 24 member 4 2 2
MIRT691837 TMCO1 transmembrane and coiled-coil domains 1 2 2
MIRT691972 PLCXD1 phosphatidylinositol specific phospholipase C X domain containing 1 2 2
MIRT692051 PAK1IP1 PAK1 interacting protein 1 2 2
MIRT692197 POLR1E RNA polymerase I subunit E 2 2
MIRT692771 NDUFS5 NADH:ubiquinone oxidoreductase subunit S5 2 2
MIRT692863 ZSWIM1 zinc finger SWIM-type containing 1 2 2
MIRT693076 AS3MT arsenite methyltransferase 2 2
MIRT693125 SCNM1 sodium channel modifier 1 2 2
MIRT693182 NPR1 natriuretic peptide receptor 1 2 2
MIRT693518 MOB3A MOB kinase activator 3A 2 2
MIRT693579 PIGR polymeric immunoglobulin receptor 2 2
MIRT693803 RHOG ras homolog family member G 2 2
MIRT694082 RNASEH2B ribonuclease H2 subunit B 2 2
MIRT694167 SLC36A2 solute carrier family 36 member 2 2 2
MIRT694266 RGS9BP regulator of G protein signaling 9 binding protein 2 2
MIRT694560 BPNT1 3'(2'), 5'-bisphosphate nucleotidase 1 2 2
MIRT694783 BVES blood vessel epicardial substance 2 2
MIRT695049 ALG10B ALG10B, alpha-1,2-glucosyltransferase 2 2
MIRT695438 TCF23 transcription factor 23 2 2
MIRT695570 ZNF562 zinc finger protein 562 2 2
MIRT696372 EIF2S3 eukaryotic translation initiation factor 2 subunit gamma 2 2
MIRT696537 C3 complement C3 2 2
MIRT696582 TTC21B tetratricopeptide repeat domain 21B 2 2
MIRT696783 DHODH dihydroorotate dehydrogenase (quinone) 2 2
MIRT697079 PSMC4 proteasome 26S subunit, ATPase 4 2 2
MIRT697108 GPKOW G-patch domain and KOW motifs 2 2
MIRT697464 ZC3H4 zinc finger CCCH-type containing 4 2 2
MIRT697502 ZBTB8B zinc finger and BTB domain containing 8B 2 2
MIRT697634 WSB1 WD repeat and SOCS box containing 1 2 2
MIRT697971 TSPYL1 TSPY like 1 2 2
MIRT698375 TMED4 transmembrane p24 trafficking protein 4 2 2
MIRT698563 TFDP2 transcription factor Dp-2 2 2
MIRT698978 SPAST spastin 2 2
MIRT699051 SOAT1 sterol O-acyltransferase 1 2 2
MIRT699099 SNRPD3 small nuclear ribonucleoprotein D3 polypeptide 2 2
MIRT699494 SLC10A6 solute carrier family 10 member 6 2 2
MIRT699590 SIKE1 suppressor of IKBKE 1 2 2
MIRT699609 SHOC2 SHOC2, leucine rich repeat scaffold protein 2 2
MIRT700156 RNF115 ring finger protein 115 2 2
MIRT700422 QDPR quinoid dihydropteridine reductase 2 2
MIRT700474 PURB purine rich element binding protein B 2 2
MIRT700550 PTBP2 polypyrimidine tract binding protein 2 2 2
MIRT700778 PLA2G4A phospholipase A2 group IVA 2 2
MIRT700879 PER2 period circadian clock 2 2 2
MIRT700956 PDP2 pyruvate dehyrogenase phosphatase catalytic subunit 2 2 2
MIRT701176 PACS2 phosphofurin acidic cluster sorting protein 2 2 2
MIRT701285 NUP210 nucleoporin 210 2 2
MIRT701483 NEK9 NIMA related kinase 9 2 2
MIRT701665 MYH9 myosin heavy chain 9 2 2
MIRT701783 MSL2 MSL complex subunit 2 2 2
MIRT701794 MSANTD4 Myb/SANT DNA binding domain containing 4 with coiled-coils 2 2
MIRT702798 IFNAR2 interferon alpha and beta receptor subunit 2 2 2
MIRT703130 GPRC5A G protein-coupled receptor class C group 5 member A 2 2
MIRT703257 GNS glucosamine (N-acetyl)-6-sulfatase 2 2
MIRT703400 GABPB1 GA binding protein transcription factor beta subunit 1 2 2
MIRT703451 FYTTD1 forty-two-three domain containing 1 2 2
MIRT703661 FAM60A SIN3-HDAC complex associated factor 2 2
MIRT703769 FAM118A family with sequence similarity 118 member A 2 2
MIRT703866 ERN1 endoplasmic reticulum to nucleus signaling 1 2 2
MIRT704668 CLCC1 chloride channel CLIC like 1 2 2
MIRT704816 CDC73 cell division cycle 73 2 2
MIRT704952 CCDC120 coiled-coil domain containing 120 2 2
MIRT705548 ARL10 ADP ribosylation factor like GTPase 10 2 2
MIRT705629 AP1S3 adaptor related protein complex 1 sigma 3 subunit 2 2
MIRT705686 ANKRD40 ankyrin repeat domain 40 2 2
MIRT706242 SYT15 synaptotagmin 15 2 2
MIRT706571 EIF2AK2 eukaryotic translation initiation factor 2 alpha kinase 2 2 2
MIRT706693 COL13A1 collagen type XIII alpha 1 chain 2 2
MIRT708930 RPP14 ribonuclease P/MRP subunit p14 2 2
MIRT708950 FZR1 fizzy and cell division cycle 20 related 1 2 2
MIRT710613 ZNF555 zinc finger protein 555 2 2
MIRT711721 IREB2 iron responsive element binding protein 2 2 2
MIRT713161 YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta 2 2
MIRT714471 KLF13 Kruppel like factor 13 2 2
MIRT716875 PTK2B protein tyrosine kinase 2 beta 2 2
MIRT717148 DLEU1 deleted in lymphocytic leukemia 1 (non-protein coding) 2 2
MIRT717995 C9orf171 cilia and flagella associated protein 77 2 2
MIRT724122 PKNOX1 PBX/knotted 1 homeobox 1 2 2
MIRT725317 NLRC5 NLR family CARD domain containing 5 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-6808-5p Cisplatin 5460033 NSC119875 approved resistant High Hypopharyngeal Cancer cell line (FaDu)
hsa-miR-6808-5p Doxorubicin 31703 NSC123127 approved sensitive cell line (BAS)
hsa-miR-6808-5p Tamoxifen 2733525 NSC180973 approved sensitive cell line (LCC2)

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