| pre-miRNA Information | |
|---|---|
| pre-miRNA | hsa-mir-367 |
| Genomic Coordinates | chr4: 112647874 - 112647941 |
| Synonyms | MIRN367, hsa-mir-367, MIR367 |
| Description | Homo sapiens miR-367 stem-loop |
| Comment | None |
| RNA Secondary Structure |  |
| Associated Diseases |  |
| Mature miRNA Information | ||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Mature miRNA | hsa-miR-367-3p | |||||||||||||||||||||
| Sequence | 44| AAUUGCACUUUAGCAAUGGUGA |65 | |||||||||||||||||||||
| Evidence | Experimental | |||||||||||||||||||||
| Experiments | Cloned | DRVs in miRNA |
|
|||||||||||||||||||
| SNPs in miRNA |
|
|||||||||||||||||||||
| Putative Targets | ||||||||||||||||||||||
| Gene Information | |||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Gene Symbol | HMGA2 | ||||||||||||||||||||
| Synonyms | BABL, HMGI-C, HMGIC, LIPO, STQTL9 | ||||||||||||||||||||
| Description | high mobility group AT-hook 2 | ||||||||||||||||||||
| Transcript | NM_003483 | ||||||||||||||||||||
| Other Transcripts | NM_003484 | ||||||||||||||||||||
| Expression | |||||||||||||||||||||
| Putative miRNA Targets on HMGA2 | |||||||||||||||||||||
| 3'UTR of HMGA2 (miRNA target sites are highlighted) |
>HMGA2|NM_003483|3'UTR 1 GGGGCGCCAACGTTCGATTTCTACCTCAGCAGCAGTTGGATCTTTTGAAGGGAGAAGACACTGCAGTGACCACTTATTCT 81 GTATTGCCATGGTCTTTCCACTTTCATCTGGGGTGGGGTGGGGTGGGGTGGGGGAGGGGGGGGTGGGGTGGGGAGAAATC 161 ACATAACCTTAAAAAGGACTATATTAATCACCTTCTTTGTAATCCCTTCACAGTCCCAGGTTTAGTGAAAAACTGCTGTA 241 AACACAGGGGACACAGCTTAACAATGCAACTTTTAATTACTGTTTTCTTTTTTCTTAACCTACTAATAGTTTGTTGATCT 321 GATAAGCAAGAGTGGGCGGGTGAGAAAAACCGAATTGGGTTTAGTCAATCACTGCACTGCATGCAAACAAGAAACGTGTC 401 ACACTTGTGACGTCGGGCATTCATATAGGAAGAACGCGGTGTGTAACACTGTGTACACCTCAAATACCACCCCAACCCAC 481 TCCCTGTAGTGAATCCTCTGTTTAGAACACCAAAGATAAGGACTAGATACTACTTTCTCTTTTTCGTATAATCTTGTAGA 561 CACTTACTTGATGATTTTTAACTTTTTATTTCTAAATGAGACGAAATGCTGATGTATCCTTTCATTCAGCTAACAAACTA 641 GAAAAGGTTATGTTCATTTTTCAAAAAGGGAAGTAAGCAAACAAATATTGCCAACTCTTCTATTTATGGATATCACACAT 721 ATCAGCAGGAGTAATAAATTTACTCACAGCACTTGTTTTCAGGACAACACTTCATTTTCAGGAAATCTACTTCCTACAGA 801 GCCAAAATGCCATTTAGCAATAAATAACACTTGTCAGCCTCAGAGCATTTAAGGAAACTAGACAAGTAAAATTATCCTCT 881 TTGTAATTTAATGAAAAGGTACAACAGAATAATGCATGATGAACTCACCTAATTATGAGGTGGGAGGAGCGAAATCTAAA 961 TTTCTTTTGCTATAGTTATACATCAATTTAAAAAGCAAAAAAAAAAAAGGGGGGGGCAATCTCTCTCTGTGTCTTTCTCT 1041 CTCTCTCTTCCTCTCCCTCTCTCTTTTCATTGTGTATCAGTTTCCATGAAAGACCTGAATACCACTTACCTCAAATTAAG 1121 CATATGTGTTACTTCAAGTAATACGTTTTGACATAAGATGGTTGACCAAGGTGCTTTTCTTCGGCTTGAGTTCACCATCT 1201 CTTCATTCAAACTGCACTTTTAGCCAGAGATGCAATATATCCCCACTACTCAATACTACCTCTGAATGTTACAACGAATT 1281 TACAGTCTAGTACTTATTACATGCTGCTATACACAAGCAATGCAAGAAAAAAACTTACTGGGTAGGTGATTCTAATCATC 1361 TGCAGTTCTTTTTGTACACTTAATTACAGTTAAAGAAGCAATCTCCTTACTGTGTTTCAGCATGACTATGTATTTTTCTA 1441 TGTTTTTTTAATTAAAAATTTTTAAAATACTTGTTTCAGCTTCTCTGCTAGATTTCTACATTAACTTGAAAATTTTTTAA 1521 CCAAGTCGCTCCTAGGTTCTTAAGGATAATTTTCCTCAATCACACTACACATCACACAAGATTTGACTGTAATATTTAAA 1601 TATTACCCTCCAAGTCTGTACCTCAAATGAATTCTTTAAGGAGATGGACTAATTGACTTGCAAAGACCTACCTCCAGACT 1681 TCAAAAGGAATGAACTTGTTACTTGCAGCATTCATTTGTTTTTTCAATGTTTGAAATAGTTCAAACTGCAGCTAACCCTA 1761 GTCAAAACTATTTTTGTAAAAGACATTTGATAGAAAGGAACACGTTTTTACATACTTTTGCAAAATAAGTAAATAATAAA 1841 TAAAATAAAAGCCAACCTTCAAAGAAACTTGAAGCTTTGTAGGTGAGATGCAACAAGCCCTGCTTTTGCATAATGCAATC 1921 AAAAATATGTGTTTTTAAGATTAGTTGAATATAAGAAAATGCTTGACAAATATTTTCATGTATTTTACACAAATGTGATT 2001 TTTGTAATATGTCTCAACCAGATTTATTTTAAACGCTTCTTATGTAGAGTTTTTATGCCTTTCTCTCCTAGTGAGTGTGC 2081 TGACTTTTTAACATGGTATTATCAACTGGGCCAGGAGGTAGTTTCTCATGACGGCTTTTGTCAGTATGGCTTTTAGTACT 2161 GAAGCCAAATGAAACTCAAAACCATCTCTCTTCCAGCTGCTTCAGGGAGGTAGTTTCAAAGGCCACATACCTCTCTGAGA 2241 CTGGCAGATCGCTCACTGTTGTGAATCACCAAAGGAGCTATGGAGAGAATTAAAACTCAACATTACTGTTAACTGTGCGT 2321 TAAATAAGCAAATAAACAGTGGCTCATAAAAATAAAAGTCGCATTCCATATCTTTGGATGGGCCTTTTAGAAACCTCATT 2401 GGCCAGCTCATAAAATGGAAGCAATTGCTCATGTTGGCCAAACATGGTGCACCGAGTGATTTCCATCTCTGGTAAAGTTA 2481 CACTTTTATTTCCTGTATGTTGTACAATCAAAACACACTACTACCTCTTAAGTCCCAGTATACCTCATTTTTCATACTGA 2561 AAAAAAAAGCTTGTGGCCAATGGAACAGTAAGAACATCATAAAATTTTTATATATATAGTTTATTTTTGTGGGAGATAAA 2641 TTTTATAGGACTGTTCTTTGCTGTTGTTGGTCGCAGCTACATAAGACTGGACATTTAACTTTTCTACCATTTCTGCAAGT 2721 TAGGTATGTTTGCAGGAGAAAAGTATCAAGACGTTTAACTGCAGTTGACTTTCTCCCTGTTCCTTTGAGTGTCTTCTAAC 2801 TTTATTCTTTGTTCTTTATGTAGAATTGCTGTCTATGATTGTACTTTGAATCGCTTGCTTGTTGAAAATATTTCTCTAGT 2881 GTATTATCACTGTCTGTTCTGCACAATAAACATAACAGCCTCTGTGATCCCCATGTGTTTTGATTCCTGCTCTTTGTTAC 2961 AGTTCCATTAAATGAGTAATAAAGTTTGGTCAAAACAGAAAAAAAAAAA Target sites
Provided by authors
Predicted by miRanda
DRVs
SNPs
DRVs & SNPs
|
||||||||||||||||||||
| miRNA-target interactions (Predicted by miRanda) |
|
||||||||||||||||||||
| DRVs in gene 3'UTRs | |||||||||||||||||||||
| SNPs in gene 3'UTRs | |||||||||||||||||||||
| Experimental Support 1 for Functional miRNA-Target Interaction | |
|---|---|
| miRNA:Target | ---- |
| Validation Method |
|
| Conditions | HEK293 |
| Disease | 8091.0 |
| Location of target site | 3'UTR |
| Tools used in this research | TargetScan , miRTarCLIP , Piranha |
| Original Description (Extracted from the article) |
...
"PAR-CLIP data was present in GSM714644. RNA binding protein: AGO2. Condition:completeT1
... - Kishore S; Jaskiewicz L; Burger L; Hausser et al., 2011, Nature methods. |
| Article |
- Kishore S; Jaskiewicz L; Burger L; Hausser et al. - Nature methods, 2011
Cross-linking and immunoprecipitation (CLIP) is increasingly used to map transcriptome-wide binding sites of RNA-binding proteins. We developed a method for CLIP data analysis, and applied it to compare CLIP with photoactivatable ribonucleoside-enhanced CLIP (PAR-CLIP) and to uncover how differences in cross-linking and ribonuclease digestion affect the identified sites. We found only small differences in accuracies of these methods in identifying binding sites of HuR, which binds low-complexity sequences, and Argonaute 2, which has a complex binding specificity. We found that cross-link-induced mutations led to single-nucleotide resolution for both PAR-CLIP and CLIP. Our results confirm the expectation from original CLIP publications that RNA-binding proteins do not protect their binding sites sufficiently under the denaturing conditions used during the CLIP procedure, and we show that extensive digestion with sequence-specific RNases strongly biases the recovered binding sites. This bias can be substantially reduced by milder nuclease digestion conditions.
LinkOut: [PMID: 21572407]
|
| Experimental Support 2 for Functional miRNA-Target Interaction | |
|---|---|
| miRNA:Target | ---- |
| Validation Method |
|
| Conditions | HCT116 |
| Location of target site | 3'UTR |
| Tools used in this research | TargetScan , miRTarCLIP , Piranha |
| Original Description (Extracted from the article) |
...
PAR-CLIP data was present in ERX177599. RNA binding protein: AGO2. Condition:p53_D_AGO_CLIP_2_1
PAR-CLIP data was present in ERX177623. RNA binding protein: AGO2. Condition:p53_D_AGO_CLIP_4_1
PAR-CLIP data was present in ERX177600. RNA binding protein: AGO2. Condition:p53_V_Ago_CLIP_2_2
PAR-CLIP data was present in ERX177612. RNA binding protein: AGO2. Condition:p53_V_AGO_CLIP_3_2
PAR-CLIP data was present in ERX177624. RNA binding protein: AGO2. Condition:p53_V_AGO_CLIP_4_2
... - Krell J; Stebbing J; Carissimi C; Dabrowska et al., 2016, Genome research. |
| Article |
- Krell J; Stebbing J; Carissimi C; Dabrowska et al. - Genome research, 2016
DNA damage activates TP53-regulated surveillance mechanisms that are crucial in suppressing tumorigenesis. TP53 orchestrates these responses directly by transcriptionally modulating genes, including microRNAs (miRNAs), and by regulating miRNA biogenesis through interacting with the DROSHA complex. However, whether the association between miRNAs and AGO2 is regulated following DNA damage is not yet known. Here, we show that, following DNA damage, TP53 interacts with AGO2 to induce or reduce AGO2's association of a subset of miRNAs, including multiple let-7 family members. Furthermore, we show that specific mutations in TP53 decrease rather than increase the association of let-7 family miRNAs, reducing their activity without preventing TP53 from interacting with AGO2. This is consistent with the oncogenic properties of these mutants. Using AGO2 RIP-seq and PAR-CLIP-seq, we show that the DNA damage-induced increase in binding of let-7 family members to the RISC complex is functional. We unambiguously determine the global miRNA-mRNA interaction networks involved in the DNA damage response, validating them through the identification of miRNA-target chimeras formed by endogenous ligation reactions. We find that the target complementary region of the let-7 seed tends to have highly fixed positions and more variable ones. Additionally, we observe that miRNAs, whose cellular abundance or differential association with AGO2 is regulated by TP53, are involved in an intricate network of regulatory feedback and feedforward circuits. TP53-mediated regulation of AGO2-miRNA interaction represents a new mechanism of miRNA regulation in carcinogenesis.
LinkOut: [PMID: 26701625]
|
| CLIP-seq Support 1 for dataset GSM714644 | |
|---|---|
| Method / RBP | PAR-CLIP / AGO2 |
| Cell line / Condition | HEK293 / completeT1, repA |
| Location of target site | ENST00000403681.2 | 3UTR | CAAUAUAUCCCCACUACUCAAUACUACCUCUGA |
| Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
| Article / Accession Series | PMID: 21572407 / GSE28865 |
| CLIP-seq Viewer | Link |
| MiRNA-Target Expression Profile | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
| MiRNA-Target Expression Profile (TCGA) | |||||||
|---|---|---|---|---|---|---|---|
|
255 hsa-miR-367-3p Target Genes:
Functional analysis:
ID |
Target | Description | Validation methods |
 |
 |
|||||||
| Strong evidence | Less strong evidence | |||||||||||
 |
 |
 |
 |
 |
 |
 |
 |
|||||
| MIRT055315 | DUSP5 | dual specificity phosphatase 5 |  |
|
2 | 8 | ||||||
| MIRT055791 | PLEKHA1 | pleckstrin homology domain containing A1 | |
|
2 | 12 | ||||||
| MIRT057114 | DDIT4 | DNA damage inducible transcript 4 | |
|
2 | 4 | ||||||
| MIRT059663 | GATAD2B | GATA zinc finger domain containing 2B | |
|
2 | 2 | ||||||
| MIRT059926 | ZDHHC5 | zinc finger DHHC-type containing 5 | |
|
2 | 2 | ||||||
| MIRT061610 | BTG2 | BTG anti-proliferation factor 2 | |
|
2 | 6 | ||||||
| MIRT066478 | HMGA2 | high mobility group AT-hook 2 | |
|
2 | 2 | ||||||
| MIRT069388 | ZFYVE21 | zinc finger FYVE-type containing 21 | |
|
2 | 2 | ||||||
| MIRT069972 | GEMIN2 | gem nuclear organelle associated protein 2 | |
|
2 | 2 | ||||||
| MIRT074764 | CNEP1R1 | CTD nuclear envelope phosphatase 1 regulatory subunit 1 | |
|
2 | 2 | ||||||
| MIRT076199 | GID4 | GID complex subunit 4 homolog | |
|
2 | 6 | ||||||
| MIRT077512 | UBE2Z | ubiquitin conjugating enzyme E2 Z | |
|
2 | 4 | ||||||
| MIRT077903 | TOB1 | transducer of ERBB2, 1 | |
|
2 | 6 | ||||||
| MIRT082250 | MED29 | mediator complex subunit 29 | |
|
2 | 4 | ||||||
| MIRT082434 | CIC | capicua transcriptional repressor | |
|
2 | 6 | ||||||
| MIRT082474 | PPP1R37 | protein phosphatase 1 regulatory subunit 37 | |
|
2 | 2 | ||||||
| MIRT082778 | ZNF264 | zinc finger protein 264 | |
|
2 | 2 | ||||||
| MIRT084533 | BCL2L11 | BCL2 like 11 | |
|
2 | 8 | ||||||
| MIRT085309 | UBXN4 | UBX domain protein 4 | |
|
2 | 8 | ||||||
| MIRT086365 | SSFA2 | sperm specific antigen 2 | |
|
2 | 8 | ||||||
| MIRT087455 | NF2 | neurofibromin 2 | |
|
2 | 2 | ||||||
| MIRT088865 | FOXN2 | forkhead box N2 | |
|
2 | 12 | ||||||
| MIRT092185 | ITPR1 | inositol 1,4,5-trisphosphate receptor type 1 | |
|
2 | 6 | ||||||
| MIRT092326 | EDEM1 | ER degradation enhancing alpha-mannosidase like protein 1 | |
|
2 | 6 | ||||||
| MIRT093533 | GALNT7 | polypeptide N-acetylgalactosaminyltransferase 7 | |
|
2 | 6 | ||||||
| MIRT096935 | PAPD7 | poly(A) RNA polymerase D7, non-canonical | |
|
2 | 8 | ||||||
| MIRT097026 | MAP1B | microtubule associated protein 1B | |
|
2 | 4 | ||||||
| MIRT099137 | MYLIP | myosin regulatory light chain interacting protein | |
|
2 | 6 | ||||||
| MIRT099905 | SOX4 | SRY-box 4 | |
|
2 | 12 | ||||||
| MIRT102289 | DNAJB9 | DnaJ heat shock protein family (Hsp40) member B9 | |
|
2 | 10 | ||||||
| MIRT102507 | KLHDC10 | kelch domain containing 10 | |
|
2 | 2 | ||||||
| MIRT102891 | INSIG1 | insulin induced gene 1 | |
|
2 | 2 | ||||||
| MIRT109188 | VMA21 | VMA21, vacuolar ATPase assembly factor | |
|
2 | 4 | ||||||
| MIRT124567 | PRRC2B | proline rich coiled-coil 2B | |
|
2 | 2 | ||||||
| MIRT135568 | SPRYD4 | SPRY domain containing 4 | |
|
2 | 2 | ||||||
| MIRT161135 | SLC25A36 | solute carrier family 25 member 36 | |
|
2 | 6 | ||||||
| MIRT163995 | KIAA1109 | KIAA1109 | |
|
2 | 4 | ||||||
| MIRT164689 | RNF4 | ring finger protein 4 | |
|
2 | 2 | ||||||
| MIRT167705 | HIVEP1 | human immunodeficiency virus type I enhancer binding protein 1 | |
|
2 | 8 | ||||||
| MIRT178956 | USP28 | ubiquitin specific peptidase 28 | |
|
2 | 2 | ||||||
| MIRT185717 | ARNTL2 | aryl hydrocarbon receptor nuclear translocator like 2 | |
|
2 | 2 | ||||||
| MIRT186264 | TCEB3 | elongin A | |
|
2 | 2 | ||||||
| MIRT186537 | TWF1 | twinfilin actin binding protein 1 | |
|
2 | 4 | ||||||
| MIRT186628 | COX20 | COX20, cytochrome c oxidase assembly factor | |
|
2 | 8 | ||||||
| MIRT189373 | TXLNA | taxilin alpha | |
|
2 | 4 | ||||||
| MIRT197013 | EIF1 | eukaryotic translation initiation factor 1 | |
|
2 | 10 | ||||||
| MIRT206437 | YIPF4 | Yip1 domain family member 4 | |
|
2 | 2 | ||||||
| MIRT211228 | FGF2 | fibroblast growth factor 2 | |
|
2 | 10 | ||||||
| MIRT214529 | C5ORF24 | chromosome 5 open reading frame 24 | |
|
2 | 2 | ||||||
| MIRT216034 | IL6ST | interleukin 6 signal transducer | |
|
2 | 10 | ||||||
| MIRT218084 | TULP4 | tubby like protein 4 | |
|
2 | 2 | ||||||
| MIRT242418 | CCDC113 | coiled-coil domain containing 113 | |
|
2 | 2 | ||||||
| MIRT243162 | SOX11 | SRY-box 11 | |
|
2 | 2 | ||||||
| MIRT250943 | CDK5R1 | cyclin dependent kinase 5 regulatory subunit 1 | |
|
2 | 4 | ||||||
| MIRT253350 | ZNF417 | zinc finger protein 417 | |
|
2 | 2 | ||||||
| MIRT271968 | ARF1 | ADP ribosylation factor 1 | |
|
2 | 2 | ||||||
| MIRT273214 | ZNF695 | zinc finger protein 695 | |
|
2 | 4 | ||||||
| MIRT296114 | SLC12A5 | solute carrier family 12 member 5 | |
|
2 | 2 | ||||||
| MIRT301711 | TEF | TEF, PAR bZIP transcription factor | |
|
2 | 2 | ||||||
| MIRT316477 | ARID1B | AT-rich interaction domain 1B | |
|
2 | 6 | ||||||
| MIRT322174 | CLN8 | CLN8, transmembrane ER and ERGIC protein | |
|
2 | 4 | ||||||
| MIRT341538 | CNIH1 | cornichon family AMPA receptor auxiliary protein 1 | |
|
2 | 6 | ||||||
| MIRT356062 | SMARCA5 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 | |
|
2 | 2 | ||||||
| MIRT443579 | PPIC | peptidylprolyl isomerase C | |
|
2 | 2 | ||||||
| MIRT448825 | FKBP1A | FK506 binding protein 1A | |
|
2 | 4 | ||||||
| MIRT451494 | FOPNL | FGFR1OP N-terminal like | |
|
2 | 2 | ||||||
| MIRT452694 | MDM2 | MDM2 proto-oncogene | |
|
2 | 2 | ||||||
| MIRT453167 | CNOT4 | CCR4-NOT transcription complex subunit 4 | |
|
2 | 6 | ||||||
| MIRT454588 | SLC33A1 | solute carrier family 33 member 1 | |
|
2 | 4 | ||||||
| MIRT455794 | TAF8 | TATA-box binding protein associated factor 8 | |
|
2 | 4 | ||||||
| MIRT456010 | CYP2C19 | cytochrome P450 family 2 subfamily C member 19 | |
|
2 | 2 | ||||||
| MIRT456044 | KIAA1586 | KIAA1586 | |
|
2 | 2 | ||||||
| MIRT456763 | TMEM239 | transmembrane protein 239 | |
|
2 | 4 | ||||||
| MIRT458068 | NLRP9 | NLR family pyrin domain containing 9 | |
|
2 | 2 | ||||||
| MIRT459230 | MRPS21 | mitochondrial ribosomal protein S21 | |
|
2 | 2 | ||||||
| MIRT459534 | MFF | mitochondrial fission factor | |
|
2 | 6 | ||||||
| MIRT459759 | SNRPD1 | small nuclear ribonucleoprotein D1 polypeptide | |
|
2 | 2 | ||||||
| MIRT460236 | TNFRSF13C | TNF receptor superfamily member 13C | |
|
2 | 2 | ||||||
| MIRT461104 | OPA3 | OPA3, outer mitochondrial membrane lipid metabolism regulator | |
|
2 | 2 | ||||||
| MIRT462924 | ZNRF3 | zinc and ring finger 3 | |
|
2 | 2 | ||||||
| MIRT463476 | ZC3HAV1L | zinc finger CCCH-type containing, antiviral 1 like | |
|
2 | 2 | ||||||
| MIRT463516 | ZBTB8B | zinc finger and BTB domain containing 8B | |
|
2 | 4 | ||||||
| MIRT465503 | TOR1B | torsin family 1 member B | |
|
2 | 2 | ||||||
| MIRT469525 | RBFOX2 | RNA binding protein, fox-1 homolog 2 | |
|
2 | 8 | ||||||
| MIRT470079 | PTGES2 | prostaglandin E synthase 2 | |
|
2 | 2 | ||||||
| MIRT471581 | PARD6B | par-6 family cell polarity regulator beta | |
|
2 | 2 | ||||||
| MIRT473451 | MCOLN2 | mucolipin 2 | |
|
2 | 8 | ||||||
| MIRT475882 | H3F3C | H3 histone family member 3C | |
|
2 | 10 | ||||||
| MIRT475915 | H3F3B | H3 histone family member 3B | |
|
2 | 8 | ||||||
| MIRT476195 | GOLGA8A | golgin A8 family member A | |
|
2 | 10 | ||||||
| MIRT476318 | GM2A | GM2 ganglioside activator | |
|
2 | 2 | ||||||
| MIRT476676 | FUT11 | fucosyltransferase 11 | |
|
2 | 10 | ||||||
| MIRT478368 | DDI2 | DNA damage inducible 1 homolog 2 | |
|
2 | 2 | ||||||
| MIRT479545 | CDC5L | cell division cycle 5 like | |
|
2 | 2 | ||||||
| MIRT481024 | BAZ2B | bromodomain adjacent to zinc finger domain 2B | |
|
2 | 2 | ||||||
| MIRT491009 | ATF7IP | activating transcription factor 7 interacting protein | |
|
2 | 2 | ||||||
| MIRT493168 | MKNK2 | MAP kinase interacting serine/threonine kinase 2 | |
|
2 | 2 | ||||||
| MIRT494345 | CASKIN1 | CASK interacting protein 1 | |
|
2 | 2 | ||||||
| MIRT499087 | ZDHHC21 | zinc finger DHHC-type containing 21 | |
|
2 | 6 | ||||||
| MIRT500029 | ABCF2 | ATP binding cassette subfamily F member 2 | |
|
2 | 8 | ||||||
| MIRT501298 | RRN3 | RRN3 homolog, RNA polymerase I transcription factor | |
|
2 | 4 | ||||||
| MIRT503124 | BCL11B | B-cell CLL/lymphoma 11B | |
|
2 | 8 | ||||||
| MIRT503301 | GTF2A1 | general transcription factor IIA subunit 1 | |
|
2 | 6 | ||||||
| MIRT504328 | ASGR2 | asialoglycoprotein receptor 2 | |
|
2 | 6 | ||||||
| MIRT504471 | EID2B | EP300 interacting inhibitor of differentiation 2B | |
|
2 | 2 | ||||||
| MIRT504655 | RPL9 | ribosomal protein L9 | |
|
2 | 6 | ||||||
| MIRT505331 | TMF1 | TATA element modulatory factor 1 | |
|
2 | 8 | ||||||
| MIRT505732 | SERTAD3 | SERTA domain containing 3 | |
|
2 | 4 | ||||||
| MIRT505827 | RSBN1 | round spermatid basic protein 1 | |
|
2 | 8 | ||||||
| MIRT506004 | PURG | purine rich element binding protein G | |
|
2 | 8 | ||||||
| MIRT506308 | PCMTD1 | protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1 | |
|
2 | 6 | ||||||
| MIRT506806 | KLHL15 | kelch like family member 15 | |
|
2 | 6 | ||||||
| MIRT507119 | GOLGA8B | golgin A8 family member B | |
|
2 | 6 | ||||||
| MIRT507353 | FAM129A | family with sequence similarity 129 member A | |
|
2 | 6 | ||||||
| MIRT507591 | DDX3X | DEAD-box helicase 3, X-linked | |
|
2 | 4 | ||||||
| MIRT507674 | CPEB4 | cytoplasmic polyadenylation element binding protein 4 | |
|
2 | 4 | ||||||
| MIRT507703 | CNOT2 | CCR4-NOT transcription complex subunit 2 | |
|
2 | 8 | ||||||
| MIRT508012 | BCAT1 | branched chain amino acid transaminase 1 | |
|
2 | 4 | ||||||
| MIRT510439 | ZIC5 | Zic family member 5 | |
|
2 | 6 | ||||||
| MIRT510539 | XKR7 | XK related 7 | |
|
2 | 4 | ||||||
| MIRT510600 | TPPP | tubulin polymerization promoting protein | |
|
2 | 6 | ||||||
| MIRT511060 | NRAS | NRAS proto-oncogene, GTPase | |
|
2 | 4 | ||||||
| MIRT511855 | GOLGA8J | golgin A8 family member J | |
|
2 | 6 | ||||||
| MIRT511865 | GOLGA8I | golgin A8 family member I, pseudogene | |
1 | 3 | |||||||
| MIRT512570 | CTDSPL | CTD small phosphatase like | |
|
2 | 2 | ||||||
| MIRT512708 | ZNF134 | zinc finger protein 134 | |
|
2 | 6 | ||||||
| MIRT513177 | MOAP1 | modulator of apoptosis 1 | |
|
2 | 6 | ||||||
| MIRT513783 | PAWR | pro-apoptotic WT1 regulator | |
|
2 | 6 | ||||||
| MIRT515099 | IRGQ | immunity related GTPase Q | |
|
2 | 2 | ||||||
| MIRT515481 | INCENP | inner centromere protein | |
|
2 | 4 | ||||||
| MIRT517416 | BMP8A | bone morphogenetic protein 8a | |
|
2 | 2 | ||||||
| MIRT518754 | C1orf35 | chromosome 1 open reading frame 35 | |
|
2 | 2 | ||||||
| MIRT519780 | ZNF354B | zinc finger protein 354B | |
|
2 | 4 | ||||||
| MIRT519865 | ZFP62 | ZFP62 zinc finger protein | |
|
2 | 6 | ||||||
| MIRT520510 | TRAM2 | translocation associated membrane protein 2 | |
|
2 | 6 | ||||||
| MIRT521068 | SLC25A32 | solute carrier family 25 member 32 | |
|
2 | 6 | ||||||
| MIRT526912 | ZNF772 | zinc finger protein 772 | |
|
2 | 6 | ||||||
| MIRT527134 | GULP1 | GULP, engulfment adaptor PTB domain containing 1 | |
|
2 | 2 | ||||||
| MIRT527867 | SLC39A14 | solute carrier family 39 member 14 | |
|
2 | 2 | ||||||
| MIRT528404 | EIF4EBP2 | eukaryotic translation initiation factor 4E binding protein 2 | |
|
2 | 2 | ||||||
| MIRT532956 | ZNF24 | zinc finger protein 24 | |
|
2 | 4 | ||||||
| MIRT533021 | ZFC3H1 | zinc finger C3H1-type containing | |
|
2 | 4 | ||||||
| MIRT533191 | WASL | Wiskott-Aldrich syndrome like | |
|
2 | 6 | ||||||
| MIRT534191 | SLC7A11 | solute carrier family 7 member 11 | |
|
2 | 2 | ||||||
| MIRT534961 | PTAR1 | protein prenyltransferase alpha subunit repeat containing 1 | |
|
2 | 4 | ||||||
| MIRT536396 | LCOR | ligand dependent nuclear receptor corepressor | |
|
2 | 2 | ||||||
| MIRT537046 | GRAMD4 | GRAM domain containing 4 | |
|
2 | 2 | ||||||
| MIRT537125 | GOLGA3 | golgin A3 | |
|
2 | 4 | ||||||
| MIRT537183 | GFPT2 | glutamine-fructose-6-phosphate transaminase 2 | |
|
2 | 4 | ||||||
| MIRT537652 | ERGIC2 | ERGIC and golgi 2 | |
|
2 | 4 | ||||||
| MIRT538632 | CCSER2 | coiled-coil serine rich protein 2 | |
|
2 | 4 | ||||||
| MIRT539231 | ANP32E | acidic nuclear phosphoprotein 32 family member E | |
|
2 | 6 | ||||||
| MIRT540099 | NPY4R | neuropeptide Y receptor Y4 | |
|
2 | 2 | ||||||
| MIRT540998 | ZNF460 | zinc finger protein 460 | |
|
2 | 4 | ||||||
| MIRT541468 | AURKA | aurora kinase A | |
|
2 | 2 | ||||||
| MIRT542680 | SESN3 | sestrin 3 | |
|
2 | 2 | ||||||
| MIRT542757 | PRRG4 | proline rich and Gla domain 4 | |
|
2 | 2 | ||||||
| MIRT542863 | NUCKS1 | nuclear casein kinase and cyclin dependent kinase substrate 1 | |
|
2 | 2 | ||||||
| MIRT542925 | HOXC8 | homeobox C8 | |
|
2 | 2 | ||||||
| MIRT543747 | SZRD1 | SUZ RNA binding domain containing 1 | |
|
2 | 2 | ||||||
| MIRT544404 | ZSCAN12 | zinc finger and SCAN domain containing 12 | |
|
2 | 2 | ||||||
| MIRT544583 | AP5Z1 | adaptor related protein complex 5 zeta 1 subunit | |
|
2 | 4 | ||||||
| MIRT544662 | MED19 | mediator complex subunit 19 | |
|
2 | 2 | ||||||
| MIRT545251 | GTF2E1 | general transcription factor IIE subunit 1 | |
|
2 | 2 | ||||||
| MIRT545261 | TRIM36 | tripartite motif containing 36 | |
|
2 | 4 | ||||||
| MIRT545744 | UHRF1BP1 | UHRF1 binding protein 1 | |
|
2 | 2 | ||||||
| MIRT545999 | WDR81 | WD repeat domain 81 | |
|
2 | 2 | ||||||
| MIRT546038 | VPS4B | vacuolar protein sorting 4 homolog B | |
|
2 | 2 | ||||||
| MIRT547170 | PDZD8 | PDZ domain containing 8 | |
|
2 | 2 | ||||||
| MIRT547273 | NUFIP2 | NUFIP2, FMR1 interacting protein 2 | |
|
2 | 2 | ||||||
| MIRT547729 | KIF5B | kinesin family member 5B | |
|
2 | 2 | ||||||
| MIRT548127 | GATA6 | GATA binding protein 6 | |
|
2 | 2 | ||||||
| MIRT548203 | FNIP1 | folliculin interacting protein 1 | |
|
2 | 2 | ||||||
| MIRT548756 | CNNM4 | cyclin and CBS domain divalent metal cation transport mediator 4 | |
|
2 | 2 | ||||||
| MIRT549641 | ZNF75A | zinc finger protein 75a | |
|
2 | 2 | ||||||
| MIRT549684 | ZNF598 | zinc finger protein 598 | |
|
2 | 2 | ||||||
| MIRT550197 | MRO | maestro | |
|
2 | 2 | ||||||
| MIRT550340 | IPP | intracisternal A particle-promoted polypeptide | |
|
2 | 2 | ||||||
| MIRT550536 | MYZAP | myocardial zonula adherens protein | |
|
2 | 2 | ||||||
| MIRT550975 | TOR4A | torsin family 4 member A | |
|
2 | 2 | ||||||
| MIRT551221 | CIDEC | cell death inducing DFFA like effector c | |
|
2 | 2 | ||||||
| MIRT551355 | AGBL5 | ATP/GTP binding protein like 5 | |
|
2 | 2 | ||||||
| MIRT551571 | LETM1 | leucine zipper and EF-hand containing transmembrane protein 1 | |
|
2 | 2 | ||||||
| MIRT552277 | RAB3D | RAB3D, member RAS oncogene family | |
|
2 | 2 | ||||||
| MIRT552661 | ZADH2 | zinc binding alcohol dehydrogenase domain containing 2 | |
|
2 | 2 | ||||||
| MIRT553081 | UCK2 | uridine-cytidine kinase 2 | |
|
2 | 2 | ||||||
| MIRT553753 | TBC1D8 | TBC1 domain family member 8 | |
|
2 | 2 | ||||||
| MIRT554030 | SPCS3 | signal peptidase complex subunit 3 | |
|
2 | 2 | ||||||
| MIRT554099 | SMU1 | DNA replication regulator and spliceosomal factor | |
|
2 | 2 | ||||||
| MIRT554155 | SLX4 | SLX4 structure-specific endonuclease subunit | |
|
2 | 2 | ||||||
| MIRT554815 | REL | REL proto-oncogene, NF-kB subunit | |
|
2 | 2 | ||||||
| MIRT555522 | PMEPA1 | prostate transmembrane protein, androgen induced 1 | |
|
2 | 2 | ||||||
| MIRT555597 | PIP5K1C | phosphatidylinositol-4-phosphate 5-kinase type 1 gamma | |
|
2 | 2 | ||||||
| MIRT555632 | PHLPP2 | PH domain and leucine rich repeat protein phosphatase 2 | |
|
2 | 4 | ||||||
| MIRT555679 | PGAM4 | phosphoglycerate mutase family member 4 | |
|
2 | 4 | ||||||
| MIRT555827 | PAX9 | paired box 9 | |
|
2 | 2 | ||||||
| MIRT555868 | PAIP1 | poly(A) binding protein interacting protein 1 | |
|
2 | 2 | ||||||
| MIRT555939 | NUP43 | nucleoporin 43 | |
|
2 | 2 | ||||||
| MIRT555994 | NFYB | nuclear transcription factor Y subunit beta | |
|
2 | 2 | ||||||
| MIRT556340 | MAP2K4 | mitogen-activated protein kinase kinase 4 | |
|
2 | 2 | ||||||
| MIRT556432 | LONRF3 | LON peptidase N-terminal domain and ring finger 3 | |
|
2 | 2 | ||||||
| MIRT556585 | LHFPL2 | LHFPL tetraspan subfamily member 2 | |
|
2 | 4 | ||||||
| MIRT556801 | KIAA1958 | KIAA1958 | |
|
2 | 2 | ||||||
| MIRT558047 | EXOC5 | exocyst complex component 5 | |
|
2 | 2 | ||||||
| MIRT558697 | CLTA | clathrin light chain A | |
|
2 | 2 | ||||||
| MIRT559191 | BMPR1A | bone morphogenetic protein receptor type 1A | |
|
2 | 4 | ||||||
| MIRT559639 | AKAP10 | A-kinase anchoring protein 10 | |
|
2 | 2 | ||||||
| MIRT559707 | AEN | apoptosis enhancing nuclease | |
|
2 | 2 | ||||||
| MIRT560673 | SRFBP1 | serum response factor binding protein 1 | |
|
2 | 2 | ||||||
| MIRT560990 | GPBP1L1 | GC-rich promoter binding protein 1 like 1 | |
|
2 | 2 | ||||||
| MIRT562170 | HOXA13 | homeobox A13 | |
|
2 | 2 | ||||||
| MIRT562275 | GNAQ | G protein subunit alpha q | |
|
2 | 2 | ||||||
| MIRT563624 | ZNF277 | zinc finger protein 277 | |
|
2 | 2 | ||||||
| MIRT563815 | FMN1 | formin 1 | |
|
2 | 2 | ||||||
| MIRT564096 | TLR3 | toll like receptor 3 | |
|
2 | 2 | ||||||
| MIRT565320 | TMEM41A | transmembrane protein 41A | |
|
2 | 2 | ||||||
| MIRT565986 | RNF44 | ring finger protein 44 | |
|
2 | 2 | ||||||
| MIRT566047 | REV3L | REV3 like, DNA directed polymerase zeta catalytic subunit | |
|
2 | 2 | ||||||
| MIRT568236 | C11orf24 | chromosome 11 open reading frame 24 | |
|
2 | 2 | ||||||
| MIRT568310 | BAK1 | BCL2 antagonist/killer 1 | |
|
2 | 2 | ||||||
| MIRT572376 | ATOX1 | antioxidant 1 copper chaperone | |
|
2 | 2 | ||||||
| MIRT574822 | CPEB3 | cytoplasmic polyadenylation element binding protein 3 | |
|
2 | 2 | ||||||
| MIRT609212 | PELP1 | proline, glutamate and leucine rich protein 1 | |
|
2 | 2 | ||||||
| MIRT616217 | RBM27 | RNA binding motif protein 27 | |
|
2 | 2 | ||||||
| MIRT629087 | FASLG | Fas ligand | |
|
2 | 2 | ||||||
| MIRT632124 | FKBP9 | FK506 binding protein 9 | |
|
2 | 2 | ||||||
| MIRT632576 | POLQ | DNA polymerase theta | |
|
2 | 2 | ||||||
| MIRT634799 | ENTHD1 | ENTH domain containing 1 | |
|
2 | 2 | ||||||
| MIRT636553 | ESRP1 | epithelial splicing regulatory protein 1 | |
|
2 | 2 | ||||||
| MIRT640977 | ORAI2 | ORAI calcium release-activated calcium modulator 2 | |
|
2 | 2 | ||||||
| MIRT653875 | SH2B3 | SH2B adaptor protein 3 | |
|
2 | 2 | ||||||
| MIRT655598 | OTUD7B | OTU deubiquitinase 7B | |
|
2 | 2 | ||||||
| MIRT659764 | CCDC171 | coiled-coil domain containing 171 | |
|
2 | 2 | ||||||
| MIRT660744 | ALG14 | ALG14, UDP-N-acetylglucosaminyltransferase subunit | |
|
2 | 2 | ||||||
| MIRT681037 | AAED1 | AhpC/TSA antioxidant enzyme domain containing 1 | |
|
2 | 2 | ||||||
| MIRT682305 | RBM28 | RNA binding motif protein 28 | |
|
2 | 2 | ||||||
| MIRT682573 | EIF4EBP1 | eukaryotic translation initiation factor 4E binding protein 1 | |
|
2 | 2 | ||||||
| MIRT686217 | ZNF267 | zinc finger protein 267 | |
|
2 | 2 | ||||||
| MIRT687209 | PLXNA3 | plexin A3 | |
|
2 | 2 | ||||||
| MIRT690630 | LAX1 | lymphocyte transmembrane adaptor 1 | |
|
2 | 2 | ||||||
| MIRT692419 | AGMAT | agmatinase | |
|
2 | 2 | ||||||
| MIRT694437 | MCF2L2 | MCF.2 cell line derived transforming sequence-like 2 | |
|
2 | 2 | ||||||
| MIRT700725 | PNO1 | partner of NOB1 homolog | |
|
2 | 2 | ||||||
| MIRT701549 | NARF | nuclear prelamin A recognition factor | |
|
2 | 2 | ||||||
| MIRT704379 | DAND5 | DAN domain BMP antagonist family member 5 | |
|
2 | 2 | ||||||
| MIRT707935 | PPP1R3D | protein phosphatase 1 regulatory subunit 3D | |
|
2 | 2 | ||||||
| MIRT709939 | MRPS16 | mitochondrial ribosomal protein S16 | |
|
2 | 2 | ||||||
| MIRT711371 | MED7 | mediator complex subunit 7 | |
|
2 | 2 | ||||||
| MIRT712327 | PER2 | period circadian clock 2 | |
|
2 | 2 | ||||||
| MIRT714515 | SHE | Src homology 2 domain containing E | |
|
2 | 2 | ||||||
| MIRT715520 | G2E3 | G2/M-phase specific E3 ubiquitin protein ligase | |
|
2 | 2 | ||||||
| MIRT724294 | OSMR | oncostatin M receptor | |
|
2 | 2 | ||||||
| MIRT725358 | MUC21 | mucin 21, cell surface associated | |
|
2 | 2 | ||||||
| MIRT732242 | KLF4 | Kruppel like factor 4 | |
|
|
3 | 1 | |||||
| MIRT735384 | SPAG5 | sperm associated antigen 5 | |
|
|
3 | 0 | |||||
| miRNA-Drug Associations | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
| miRNA-Drug Resistance Associations | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|