miRTarBase - #MIRT067617


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pre-miRNA Information
pre-miRNA hsa-mir-3973   
Genomic Coordinates chr11: 36010098 - 36010204
Description Homo sapiens miR-3973 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-3973
Sequence 84| ACAAAGUACAGCAUUAGCCUUAG |106
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs770990564 3 dbSNP
rs1265409247 6 dbSNP
rs776720932 7 dbSNP
rs1303596672 18 dbSNP
rs183016698 23 dbSNP
Putative Targets

Gene Information
Gene Symbol TMPO   
Synonyms CMD1T, LAP2, LEMD4, PRO0868, TP
Description thymopoietin
Transcript NM_001032283   
Other Transcripts NM_001032284 , NM_003276   
Expression
Putative miRNA Targets on TMPO
3'UTR of TMPO
(miRNA target sites are highlighted)		 
>TMPO|NM_001032283|3'UTR
   1 ATGGTATCTCTTTGGCACGTTCAACTTGGTCTCCTATTTTCAATAACTGTTGAAAAACATTTGTGTACACTTGTTGACTC
  81 CAAGAACTAAAAATAATGTGATTTCGCCTCAATAAATGTAGTATTTCATTGAAAAGCAAACAAAATATATATAAATGGAC
 161 TTCATTAAAATGTTTTTGAACTTTGGACTAGTAGGAGATCACTTTGTGCCATATGAATAATCTTTTTTAGCTCTGGAACT
 241 TTTTGTAGGCTTTATTTTTTTAATGTGGGCATCTTATTTCATTTTTGAAAAAATGTATATGTTTTTTGTGTATTTGGGAA
 321 ACGAAGGGTGAAACATGGTAGTATAATGTGAAGCTACACATTTAAATACTTAGAATTCTTACAGAAAAGATTTTAAGAAT
 401 TATTCTCTGCTGAATAAAAACTGCAAATATGTGAAACATAATGAAATTCAGTAAGAGGAAAAGTAACTTGGTTGTACTTT
 481 TTGTAACTGCAACAAAGTTTGATGGTGTTTATGAGGAAAAGTACAGCAATAATCTCTTCTGTAACCTTTATTAATAGTAA
 561 TGTTGTTGTAGCCCTATCATACTCACTTTTTAAGACACAGTATCATGAAAGTCCTATTTCAGTAAGACCCATTTACATAC
 641 AGTAGATTTTTAGCAGAGATCTTTTAGTGTAACATACATATTTTAGAGAATTGTTGGCTAGCTGTACATGTTTTGAAAAG
 721 CTGTTTAGCTAGCTATAAGGCTATAATTGGAAATTTGTATTTTTTATTTACAGCAAAACATTTATTCAGTCATCCAGTTT
 801 GCTACCAAAATATGTTTTAGATAAGTGTGTGTATGTTTGTTTAGAAGTTAGAAATTGTAAACACTGGTCTTATGTTTCAT
 881 TTGGATTCATTATTGCATTGTCTTGTTACCAGAAACAAATTTTGCCGAGCTTTTTTTGCCCTATATTTCCCAGCATAATT
 961 TGATTAGAAAGTACAAAAAGGGCCAGGCGCGGTGGCTTACGCCTGTAATCCCAGCACTTTGGGAGGCCAGGGCGGGTGGA
1041 TCACGAGGTCAAGAGATCAAGACCATCCTGGCCAACATGGTGAAACCCCGTCTCTACTAAAAATACAAAAAAATTAGCTG
1121 GGCGTGATGATGTGCGCCTGTAGTCCTGTCTACTAGGGAGACTGAGGCAGGAGAATCGTTTGAACCCAGGAGGCAGAGGT
1201 TGCAGTGAGCAGAGATTACGTCACTGCACTGTAGCCTGGCGACAGAGCAAGACTCCATCTCAAAAAAAATAAAAAAGTAC
1281 AAAAAGTACTTGCTTTTATATTACATCATAAGCAGTAGTTAATAAAGTTGTATACTCTTAAGAGGTGGGCATTATGATTA
1361 TTTTTTATTTTTTTATTTTTTATGAGATGGAGTCTCACTCTTGTCACCCAGACTGTAGTGCAGTGGCACGATCTGGGCTC
1441 GATGCAACCTCTGCCTCCCAGGTTCAAGCAATTTTCCTGCCTCGGCAGAGACGGGGTTTCACCATGTTGGCCAGGCTGGT
1521 CTCGAACCCCTGACCTCAAGTGATCAGCCCACCTCAGCTTCCCAAAGTGCTGGGATTACAGGTGTGATCCACTGCACCCG
1601 GCCGGCATTATGATTTTGTGTACTCTTGAAATGGTTATCTTTGTGGATGATTTTTTTTTTTAAGCTGAAACTTACCTCAT
1681 GAATAACTTGATTAAAGTAGTAGGTGATTAAAATTTCAATAGAATCAAATGAGACAAAAATTTTAAACTGACTCATTTGA
1761 GTTTCAACTTTACAGTCATTGACCATAAAGCACACTAAAAATGTAAGTTATTTTTAAATACATCTGAAATAAAAATACTT
1841 ACTAAAAAGGAAGAAGCCGAAGATGTATATTTAGACCAGCACACAATTTTGATTTCAATTAGCCTTATTCTAATATTTAG
1921 CTTTTAGATCTTTCATACACATTTTCACGTACTTTGCAATTGAGACCAGAAAGACTTGTAGGTCTTTCTGCAGAATGAGT
2001 GGGTCCTTGCAAAGTGAGTGGGAAACTTACTCCTAGATCAGAAATGTTTGCCTCTCTGAGTAAAATGTTTCTTTCAGATG
2081 AGCCATAGAGGGGGCACCTTTTACTCAACTTTTCTTTGTTTTGAAACTTTGTTTCCCATACTGTTTTCAGCCTTTTGTTT
2161 ATAATTAGAAATTGTGAGAAGCTTCATTTAGTGTTTAAAAATGTGGGGAGATAAATCAGACTTAACATGTATGTAAGATC
2241 AATTCACTTAAAAGTATGGTCCAAATAGCAAAAATAGGACCAGGTGAAACATGTAGTCATTTTTTAAAAACATGTACTTG
2321 GTCTTTTGTGTGTGTCTGTTTTATTCCATTAGAATAAATGTGTCCTTGATGTAAATGCAAAGCATTTCTTCCTGATTAAA
2401 TTGTAGATGTAGACTTTACAATATAATTCAATAATAAAAAGTAATTAACCTCTAGTTTTGTCGTTGCAATAAATGGTTTT
2481 CAGATAGCACAAACTGTGATTTCTGGATAACATTTCTTATGAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' gauuccgauUACGA---CAUGAAACa 5'
                   || :|   |||||||| 
Target 5' ttcatacacATTTTCACGTACTTTGc 3'
 1932 - 1957 146.00 -8.40
2 
miRNA  3' gaUUCCGAUU--A-CGACAUGAAAca 5'
            |||  |||  | |:||||||||  
Target 5' aaAAG--TAACTTGGTTGTACTTTtt 3'
 459 - 482 143.00 -11.20
3 
miRNA  3' gaUUCCG--AUUA--C----GACAUGAAAca 5'
            |||||  ||||  |    :||||:|||  
Target 5' atAAGGCTATAATTGGAAATTTGTATTTTtt 3'
 735 - 765 131.00 -14.14
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
165478 2 ClinVar
1191173 8 ClinVar
1208058 106 ClinVar
1202553 116 ClinVar
COSN31612232 13 COSMIC
COSN30668588 16 COSMIC
COSN26999184 20 COSMIC
COSN30112789 29 COSMIC
COSN30155833 53 COSMIC
COSN31578609 64 COSMIC
COSN20256746 106 COSMIC
COSN30495775 113 COSMIC
COSN1595816 146 COSMIC
COSN31599675 146 COSMIC
COSN22678710 189 COSMIC
COSN29175983 344 COSMIC
COSN31582570 385 COSMIC
COSN18932141 390 COSMIC
COSN31568023 390 COSMIC
COSN9740226 895 COSMIC
COSN9740227 896 COSMIC
COSN1595817 1078 COSMIC
COSN23305266 1091 COSMIC
COSN27265411 1647 COSMIC
COSN17918890 1654 COSMIC
COSN17915325 1655 COSMIC
COSN27258768 1662 COSMIC
COSN17917778 1669 COSMIC
COSN17950902 1760 COSMIC
COSN17952949 1773 COSMIC
COSN17897997 1780 COSMIC
COSN1595818 1783 COSMIC
COSN17954522 1796 COSMIC
COSN27621883 1866 COSMIC
COSN5796706 1933 COSMIC
COSN17905657 1950 COSMIC
COSN17901958 1951 COSMIC
COSN7388928 2258 COSMIC
COSN16467692 2352 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1058300 2 dbSNP
rs779195760 4 dbSNP
rs1471894531 5 dbSNP
rs140261783 6 dbSNP
rs1415779270 7 dbSNP
rs557563034 8 dbSNP
rs769442587 9 dbSNP
rs753340029 13 dbSNP
rs1410444575 14 dbSNP
rs762240701 17 dbSNP
rs371223654 19 dbSNP
rs765768388 20 dbSNP
rs929453380 22 dbSNP
rs1445439051 25 dbSNP
rs1285583395 29 dbSNP
rs750881740 33 dbSNP
rs758820565 35 dbSNP
rs1296069960 36 dbSNP
rs575316861 37 dbSNP
rs751763147 40 dbSNP
rs755180248 44 dbSNP
rs781146184 46 dbSNP
rs748196612 47 dbSNP
rs774635973 48 dbSNP
rs1473017511 50 dbSNP
rs1047541442 64 dbSNP
rs1253088307 65 dbSNP
rs750885955 69 dbSNP
rs1003230881 71 dbSNP
rs1249046973 71 dbSNP
rs1485933551 74 dbSNP
rs1255360130 82 dbSNP
rs758838059 86 dbSNP
rs963797805 88 dbSNP
rs1033738029 89 dbSNP
rs542319188 98 dbSNP
rs1475917147 99 dbSNP
rs7966614 106 dbSNP
rs572798790 107 dbSNP
rs1229309461 108 dbSNP
rs1802615 116 dbSNP
rs1286577844 118 dbSNP
rs1299724843 119 dbSNP
rs1396935831 121 dbSNP
rs1302792297 142 dbSNP
rs1464854331 145 dbSNP
rs774271985 148 dbSNP
rs576941099 149 dbSNP
rs977716909 150 dbSNP
rs1261534404 162 dbSNP
rs1395166591 173 dbSNP
rs1189385644 185 dbSNP
rs977879516 193 dbSNP
rs1255300358 198 dbSNP
rs192775311 212 dbSNP
rs1486719861 213 dbSNP
rs532253363 214 dbSNP
rs1353742462 215 dbSNP
rs767619165 222 dbSNP
rs1328703548 223 dbSNP
rs1266498585 226 dbSNP
rs1235151697 229 dbSNP
rs1341147369 230 dbSNP
rs1235249115 240 dbSNP
rs1312615024 252 dbSNP
rs879127229 262 dbSNP
rs990603850 267 dbSNP
rs1321592237 268 dbSNP
rs1293949610 274 dbSNP
rs915987441 277 dbSNP
rs35567478 288 dbSNP
rs763044316 288 dbSNP
rs1385909946 293 dbSNP
rs1166649148 294 dbSNP
rs1457962539 295 dbSNP
rs943382486 298 dbSNP
rs1162576101 300 dbSNP
rs1430282866 301 dbSNP
rs974098584 302 dbSNP
rs920842764 307 dbSNP
rs1187644902 315 dbSNP
rs1463387896 317 dbSNP
rs1307473056 318 dbSNP
rs1215850027 322 dbSNP
rs1242740718 323 dbSNP
rs929484458 323 dbSNP
rs868531481 324 dbSNP
rs948819584 338 dbSNP
rs1434738693 339 dbSNP
rs1047904274 340 dbSNP
rs1253530168 342 dbSNP
rs1481172777 348 dbSNP
rs1045742875 361 dbSNP
rs865862004 366 dbSNP
rs1327490465 367 dbSNP
rs907231810 371 dbSNP
rs939235782 374 dbSNP
rs1389355103 377 dbSNP
rs906296396 380 dbSNP
rs544023045 388 dbSNP
rs796478581 390 dbSNP
rs1054803631 393 dbSNP
rs1167891099 399 dbSNP
rs1447430546 400 dbSNP
rs894841617 406 dbSNP
rs1201237673 408 dbSNP
rs1266967703 416 dbSNP
rs1486433510 421 dbSNP
rs1208075398 425 dbSNP
rs1481659011 427 dbSNP
rs1275970070 432 dbSNP
rs184293463 433 dbSNP
rs779490688 438 dbSNP
rs1046992161 444 dbSNP
rs1234463449 446 dbSNP
rs1330103012 452 dbSNP
rs188145139 454 dbSNP
rs750583989 465 dbSNP
rs181982566 484 dbSNP
rs902418117 500 dbSNP
rs1172449851 511 dbSNP
rs1307325711 514 dbSNP
rs1005378359 515 dbSNP
rs1016764030 524 dbSNP
rs1427784908 527 dbSNP
rs1373512460 532 dbSNP
rs567743962 545 dbSNP
rs999333327 547 dbSNP
rs1029422044 552 dbSNP
rs1058309 554 dbSNP
rs1009356840 555 dbSNP
rs899574631 558 dbSNP
rs1373912672 559 dbSNP
rs775355654 561 dbSNP
rs11109526 572 dbSNP
rs1205040265 572 dbSNP
rs965103759 574 dbSNP
rs996583611 577 dbSNP
rs1201331579 578 dbSNP
rs920866636 580 dbSNP
rs1272714612 587 dbSNP
rs1029257680 592 dbSNP
rs528533277 598 dbSNP
rs1350533007 601 dbSNP
rs137958470 612 dbSNP
rs1407480041 620 dbSNP
rs1357224414 621 dbSNP
rs1308561479 623 dbSNP
rs1413692289 623 dbSNP
rs371174437 626 dbSNP
rs1399870481 629 dbSNP
rs1171012021 632 dbSNP
rs771880334 633 dbSNP
rs756410435 642 dbSNP
rs1413019192 662 dbSNP
rs939534175 675 dbSNP
rs1239658739 678 dbSNP
rs957890161 682 dbSNP
rs1055315100 692 dbSNP
rs990312310 705 dbSNP
rs1211004566 708 dbSNP
rs1329360942 723 dbSNP
rs1267116546 726 dbSNP
rs946396179 727 dbSNP
rs374141361 736 dbSNP
rs1211148856 744 dbSNP
rs916103570 748 dbSNP
rs1241089758 760 dbSNP
rs1380789213 760 dbSNP
rs568211593 775 dbSNP
rs1484612426 782 dbSNP
rs1187711703 784 dbSNP
rs1338457164 792 dbSNP
rs1319999399 793 dbSNP
rs1435577861 796 dbSNP
rs902452262 802 dbSNP
rs970116247 807 dbSNP
rs571994072 814 dbSNP
rs1416127351 815 dbSNP
rs981536805 817 dbSNP
rs1472733049 827 dbSNP
rs928595789 828 dbSNP
rs1190843743 829 dbSNP
rs878960887 830 dbSNP
rs1465634464 836 dbSNP
rs539306775 843 dbSNP
rs766642705 846 dbSNP
rs1322973241 848 dbSNP
rs557543224 852 dbSNP
rs1290014207 862 dbSNP
rs1018129522 863 dbSNP
rs1354112616 867 dbSNP
rs569308170 870 dbSNP
rs754296887 874 dbSNP
rs1228787898 880 dbSNP
rs1344781860 887 dbSNP
rs941298994 890 dbSNP
rs1433231755 901 dbSNP
rs1351660150 905 dbSNP
rs755400555 910 dbSNP
rs75544449 913 dbSNP
rs1412174730 918 dbSNP
rs1171108901 924 dbSNP
rs1363335681 925 dbSNP
rs1440806852 926 dbSNP
rs748688451 927 dbSNP
rs756786122 928 dbSNP
rs1235402230 932 dbSNP
rs1283143959 933 dbSNP
rs1314718852 938 dbSNP
rs1217359847 940 dbSNP
rs1260780248 942 dbSNP
rs1468022756 944 dbSNP
rs1191675214 945 dbSNP
rs1254752871 946 dbSNP
rs928191922 955 dbSNP
rs1276684825 957 dbSNP
rs1454568387 958 dbSNP
rs1205859730 964 dbSNP
rs780793470 966 dbSNP
rs890750865 969 dbSNP
rs1341170580 971 dbSNP
rs745485006 972 dbSNP
rs1407586397 976 dbSNP
rs769542202 981 dbSNP
rs1399156776 984 dbSNP
rs998521634 989 dbSNP
rs554408424 990 dbSNP
rs1363847903 991 dbSNP
rs572880195 992 dbSNP
rs990984141 994 dbSNP
rs1011862976 996 dbSNP
rs1023109095 1001 dbSNP
rs970232228 1002 dbSNP
rs1190341951 1005 dbSNP
rs1460921528 1012 dbSNP
rs1324481664 1021 dbSNP
rs1373765248 1026 dbSNP
rs916332339 1028 dbSNP
rs981484454 1029 dbSNP
rs1482666126 1033 dbSNP
rs1272405605 1034 dbSNP
rs1279305087 1035 dbSNP
rs946457598 1043 dbSNP
rs928728957 1046 dbSNP
rs1225099696 1048 dbSNP
rs950903433 1049 dbSNP
rs1279579546 1053 dbSNP
rs1218908995 1056 dbSNP
rs1343681893 1057 dbSNP
rs1284425749 1061 dbSNP
rs12816564 1082 dbSNP
rs1410542429 1083 dbSNP
rs1350348174 1086 dbSNP
rs1333542365 1089 dbSNP
rs1043380339 1090 dbSNP
rs1467901815 1091 dbSNP
rs923569742 1096 dbSNP
rs1174888895 1099 dbSNP
rs1275010503 1116 dbSNP
rs1412444296 1119 dbSNP
rs983454764 1124 dbSNP
rs1050994166 1125 dbSNP
rs909234373 1131 dbSNP
rs1249523784 1132 dbSNP
rs1230951735 1133 dbSNP
rs1483439740 1135 dbSNP
rs1236718122 1136 dbSNP
rs891024451 1137 dbSNP
rs562809468 1143 dbSNP
rs1179178097 1144 dbSNP
rs941255290 1158 dbSNP
rs1321610035 1164 dbSNP
rs1270268760 1166 dbSNP
rs942547511 1170 dbSNP
rs1038270885 1172 dbSNP
rs533571806 1178 dbSNP
rs994894123 1179 dbSNP
rs1380312362 1184 dbSNP
rs1027740198 1185 dbSNP
rs886475613 1188 dbSNP
rs1004871707 1190 dbSNP
rs1162828838 1198 dbSNP
rs1035292047 1202 dbSNP
rs186285844 1205 dbSNP
rs867271121 1214 dbSNP
rs1390301337 1215 dbSNP
rs960962895 1216 dbSNP
rs576740751 1220 dbSNP
rs991408610 1221 dbSNP
rs1166787821 1229 dbSNP
rs1397369933 1232 dbSNP
rs1406436765 1241 dbSNP
rs932496046 1242 dbSNP
rs1328671328 1248 dbSNP
rs968204668 1250 dbSNP
rs200555771 1262 dbSNP
rs979190069 1262 dbSNP
rs1444744122 1267 dbSNP
rs1050917034 1270 dbSNP
rs544061446 1271 dbSNP
rs986407149 1271 dbSNP
rs189099847 1272 dbSNP
rs942601060 1274 dbSNP
rs1052772844 1278 dbSNP
rs574590258 1290 dbSNP
rs898371207 1295 dbSNP
rs892805500 1299 dbSNP
rs1294723707 1302 dbSNP
rs1457979933 1305 dbSNP
rs1367756365 1306 dbSNP
rs566786734 1310 dbSNP
rs1161670937 1315 dbSNP
rs931128944 1316 dbSNP
rs181561458 1319 dbSNP
rs1213918883 1328 dbSNP
rs1270721471 1331 dbSNP
rs1439353882 1337 dbSNP
rs1204889495 1338 dbSNP
rs1259945361 1344 dbSNP
rs149485655 1350 dbSNP
rs1488885133 1352 dbSNP
rs781082772 1357 dbSNP
rs1004904313 1358 dbSNP
rs1344714832 1358 dbSNP
rs1185958808 1360 dbSNP
rs1303325168 1361 dbSNP
rs1420095207 1361 dbSNP
rs1034988146 1362 dbSNP
rs896738204 1367 dbSNP
rs970332260 1372 dbSNP
rs1386841669 1376 dbSNP
rs1167847178 1401 dbSNP
rs1389460818 1401 dbSNP
rs1301194351 1404 dbSNP
rs1431599518 1406 dbSNP
rs1371125751 1407 dbSNP
rs1474313078 1408 dbSNP
rs1371550105 1409 dbSNP
rs1417933203 1413 dbSNP
rs1201348387 1414 dbSNP
rs1433819243 1415 dbSNP
rs1268315321 1430 dbSNP
rs560110834 1431 dbSNP
rs1275990934 1433 dbSNP
rs1204800229 1438 dbSNP
rs186744278 1440 dbSNP
rs191087791 1441 dbSNP
rs28535939 1443 dbSNP
rs1280767711 1444 dbSNP
rs532861926 1447 dbSNP
rs1350975498 1450 dbSNP
rs1307349165 1451 dbSNP
rs183137615 1456 dbSNP
rs1174498646 1461 dbSNP
rs546816225 1472 dbSNP
rs963352990 1474 dbSNP
rs536480871 1475 dbSNP
rs973928993 1477 dbSNP
rs1225990662 1484 dbSNP
rs921170288 1485 dbSNP
rs932607469 1487 dbSNP
rs1181793875 1490 dbSNP
rs912193374 1492 dbSNP
rs986631508 1493 dbSNP
rs912411660 1494 dbSNP
rs1347499972 1497 dbSNP
rs934398077 1502 dbSNP
rs1208990940 1506 dbSNP
rs186047886 1516 dbSNP
rs7973946 1517 dbSNP
rs942359153 1522 dbSNP
rs147137090 1524 dbSNP
rs892762878 1525 dbSNP
rs947042980 1528 dbSNP
rs919827190 1530 dbSNP
rs1192512901 1531 dbSNP
rs1044124630 1533 dbSNP
rs1240909538 1542 dbSNP
rs3177178 1552 dbSNP
rs1405535421 1553 dbSNP
rs1458878542 1554 dbSNP
rs1169691377 1555 dbSNP
rs138693048 1557 dbSNP
rs3177180 1566 dbSNP
rs1046904982 1571 dbSNP
rs558138081 1577 dbSNP
rs1461152416 1580 dbSNP
rs1240883050 1581 dbSNP
rs143292209 1585 dbSNP
rs112838469 1589 dbSNP
rs1056869808 1594 dbSNP
rs1221595062 1596 dbSNP
rs189533759 1600 dbSNP
rs574657734 1601 dbSNP
rs1045343983 1606 dbSNP
rs1380385924 1611 dbSNP
rs1334944511 1612 dbSNP
rs1389700804 1615 dbSNP
rs1004931725 1617 dbSNP
rs1399046047 1619 dbSNP
rs1402408293 1620 dbSNP
rs1393432384 1621 dbSNP
rs1164412331 1623 dbSNP
rs1444370156 1626 dbSNP
rs538696480 1627 dbSNP
rs1449644031 1634 dbSNP
rs1212953367 1635 dbSNP
rs1241169359 1635 dbSNP
rs541684887 1640 dbSNP
rs374509575 1644 dbSNP
rs1221723996 1647 dbSNP
rs1356969929 1648 dbSNP
rs963466651 1650 dbSNP
rs1228897225 1651 dbSNP
rs1362856569 1651 dbSNP
rs796871694 1654 dbSNP
rs796085526 1655 dbSNP
rs1324744963 1661 dbSNP
rs1368520169 1665 dbSNP
rs796668107 1669 dbSNP
rs755347230 1672 dbSNP
rs1345939988 1674 dbSNP
rs1204681258 1688 dbSNP
rs1282231730 1690 dbSNP
rs1449302223 1692 dbSNP
rs1189783682 1693 dbSNP
rs1001003264 1695 dbSNP
rs1184466829 1696 dbSNP
rs1478711176 1696 dbSNP
rs1252859063 1698 dbSNP
rs1452995207 1700 dbSNP
rs1195841652 1704 dbSNP
rs560261582 1705 dbSNP
rs1198104004 1708 dbSNP
rs1452571733 1711 dbSNP
rs1489825733 1717 dbSNP
rs1156359832 1718 dbSNP
rs1276710414 1719 dbSNP
rs569337287 1720 dbSNP
rs1306774291 1722 dbSNP
rs1457246852 1726 dbSNP
rs1272549860 1728 dbSNP
rs1325153805 1734 dbSNP
rs1392151423 1737 dbSNP
rs1213068448 1738 dbSNP
rs1442884337 1743 dbSNP
rs573386750 1755 dbSNP
rs1018089929 1760 dbSNP
rs1222519448 1772 dbSNP
rs796608486 1773 dbSNP
rs953949390 1775 dbSNP
rs976523442 1780 dbSNP
rs1443367845 1786 dbSNP
rs1354367525 1793 dbSNP
rs1331339989 1795 dbSNP
rs918378005 1796 dbSNP
rs1273139442 1803 dbSNP
rs1283860413 1804 dbSNP
rs951009463 1808 dbSNP
rs983756844 1809 dbSNP
rs910106184 1812 dbSNP
rs937625550 1814 dbSNP
rs1056472862 1817 dbSNP
rs879872869 1821 dbSNP
rs987133737 1822 dbSNP
rs912373201 1825 dbSNP
rs1182885550 1831 dbSNP
rs879369031 1831 dbSNP
rs1163542795 1836 dbSNP
rs1392262538 1837 dbSNP
rs934490649 1839 dbSNP
rs1462937624 1841 dbSNP
rs1293966988 1844 dbSNP
rs1230921667 1845 dbSNP
rs1211999868 1847 dbSNP
rs1395515031 1854 dbSNP
rs1389404917 1855 dbSNP
rs956460371 1859 dbSNP
rs988543730 1860 dbSNP
rs914322397 1864 dbSNP
rs796414747 1866 dbSNP
rs1290730139 1869 dbSNP
rs1224864354 1870 dbSNP
rs796504942 1877 dbSNP
rs540687840 1878 dbSNP
rs753224657 1881 dbSNP
rs1007972488 1883 dbSNP
rs1335757072 1893 dbSNP
rs796852050 1897 dbSNP
rs565377594 1899 dbSNP
rs1159294579 1900 dbSNP
rs1480518011 1903 dbSNP
rs796537726 1906 dbSNP
rs796641943 1913 dbSNP
rs148592104 1917 dbSNP
rs796214596 1919 dbSNP
rs1415018655 1930 dbSNP
rs1019776972 1932 dbSNP
rs1475865378 1937 dbSNP
rs1165417121 1939 dbSNP
rs963777211 1940 dbSNP
rs142900397 1949 dbSNP
rs73140468 1950 dbSNP
rs796317350 1951 dbSNP
rs886578230 1952 dbSNP
rs1410647925 1960 dbSNP
rs1450066370 1963 dbSNP
rs796600652 1973 dbSNP
rs796224547 1975 dbSNP
rs755580709 1980 dbSNP
rs57778879 1987 dbSNP
rs774308431 1991 dbSNP
rs1314094077 1992 dbSNP
rs908335488 2010 dbSNP
rs1307385284 2011 dbSNP
rs1181555573 2012 dbSNP
rs938491547 2027 dbSNP
rs536564031 2028 dbSNP
rs899234573 2031 dbSNP
rs1485624024 2032 dbSNP
rs1259476582 2037 dbSNP
rs539986385 2040 dbSNP
rs797022001 2055 dbSNP
rs1254890002 2057 dbSNP
rs1044435 2059 dbSNP
rs1181899887 2066 dbSNP
rs566682934 2067 dbSNP
rs1261008711 2068 dbSNP
rs954726893 2076 dbSNP
rs183276162 2077 dbSNP
rs1019957591 2083 dbSNP
rs904122375 2092 dbSNP
rs1172337858 2099 dbSNP
rs1381147264 2102 dbSNP
rs1359313497 2105 dbSNP
rs1390553329 2108 dbSNP
rs746823969 2111 dbSNP
rs1425176838 2112 dbSNP
rs956015951 2114 dbSNP
rs551900221 2125 dbSNP
rs555107545 2136 dbSNP
rs570200451 2139 dbSNP
rs1373813435 2141 dbSNP
rs768412629 2146 dbSNP
rs1374999338 2148 dbSNP
rs1194242962 2160 dbSNP
rs1008802069 2186 dbSNP
rs1259795296 2189 dbSNP
rs1201727081 2192 dbSNP
rs537475355 2194 dbSNP
rs1303470051 2204 dbSNP
rs968429368 2207 dbSNP
rs979867920 2212 dbSNP
rs1220709924 2226 dbSNP
rs556101682 2227 dbSNP
rs1381020726 2228 dbSNP
rs1251503977 2233 dbSNP
rs926909198 2235 dbSNP
rs964109400 2241 dbSNP
rs1305439414 2243 dbSNP
rs996536109 2251 dbSNP
rs1027031614 2260 dbSNP
rs1344724976 2279 dbSNP
rs1233963525 2282 dbSNP
rs778732546 2284 dbSNP
rs1397011757 2293 dbSNP
rs57900732 2304 dbSNP
rs1168683897 2306 dbSNP
rs1461638751 2319 dbSNP
rs1313562225 2329 dbSNP
rs1210275987 2330 dbSNP
rs1371566754 2333 dbSNP
rs568283595 2335 dbSNP
rs1056836678 2337 dbSNP
rs371446465 2339 dbSNP
rs369299135 2347 dbSNP
rs1251639959 2349 dbSNP
rs1195609480 2361 dbSNP
rs1044514 2371 dbSNP
rs1479421410 2382 dbSNP
rs1037819208 2383 dbSNP
rs1257400266 2384 dbSNP
rs1223590052 2402 dbSNP
rs1248508104 2404 dbSNP
rs1322294844 2407 dbSNP
rs1281279269 2408 dbSNP
rs899350725 2410 dbSNP
rs200354667 2412 dbSNP
rs535703113 2414 dbSNP
rs554014065 2418 dbSNP
rs1389461813 2419 dbSNP
rs150669486 2422 dbSNP
rs748066393 2424 dbSNP
rs1009304555 2429 dbSNP
rs573391914 2432 dbSNP
rs948101474 2440 dbSNP
rs980800113 2442 dbSNP
rs1471414323 2446 dbSNP
rs1364892189 2463 dbSNP
rs956138131 2464 dbSNP
rs936669647 2468 dbSNP
rs34963912 2469 dbSNP
rs892703575 2485 dbSNP
rs760753189 2487 dbSNP
rs1260665531 2488 dbSNP
rs1323160849 2489 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM545212. RNA binding protein: AGO1. Condition:Control ...

- Hafner M; Landthaler M; Burger L; Khorshid et al., 2010, Cell.

Article - Hafner M; Landthaler M; Burger L; Khorshid et al.
- Cell, 2010
RNA transcripts are subject to posttranscriptional gene regulation involving hundreds of RNA-binding proteins (RBPs) and microRNA-containing ribonucleoprotein complexes (miRNPs) expressed in a cell-type dependent fashion. We developed a cell-based crosslinking approach to determine at high resolution and transcriptome-wide the binding sites of cellular RBPs and miRNPs. The crosslinked sites are revealed by thymidine to cytidine transitions in the cDNAs prepared from immunopurified RNPs of 4-thiouridine-treated cells. We determined the binding sites and regulatory consequences for several intensely studied RBPs and miRNPs, including PUM2, QKI, IGF2BP1-3, AGO/EIF2C1-4 and TNRC6A-C. Our study revealed that these factors bind thousands of sites containing defined sequence motifs and have distinct preferences for exonic versus intronic or coding versus untranslated transcript regions. The precise mapping of binding sites across the transcriptome will be critical to the interpretation of the rapidly emerging data on genetic variation between individuals and how these variations contribute to complex genetic diseases.
LinkOut: [PMID: 20371350]
CLIP-seq Support 1 for dataset GSM545212
Method / RBP PAR-CLIP / AGO1
Cell line / Condition HEK293 / Control
Location of target site ENST00000266732.4 | 3UTR | ACCACACUUUGAGAAACACUUCUUUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 20371350 / GSE21578
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
136 hsa-miR-3973 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT060560 CCND1 cyclin D1 2 2
MIRT060977 LAMC1 laminin subunit gamma 1 2 2
MIRT067617 TMPO thymopoietin 2 2
MIRT072503 RAB8B RAB8B, member RAS oncogene family 2 2
MIRT092048 ABHD5 abhydrolase domain containing 5 2 6
MIRT093449 MSMO1 methylsterol monooxygenase 1 2 2
MIRT093538 GALNT7 polypeptide N-acetylgalactosaminyltransferase 7 2 6
MIRT095404 UBE2D2 ubiquitin conjugating enzyme E2 D2 2 2
MIRT103367 CBX3 chromobox 3 2 2
MIRT110447 PLEKHA1 pleckstrin homology domain containing A1 2 10
MIRT161196 ZBTB38 zinc finger and BTB domain containing 38 2 2
MIRT161903 FXR1 FMR1 autosomal homolog 1 2 2
MIRT192775 B2M beta-2-microglobulin 2 2
MIRT195782 ATMIN ATM interactor 2 6
MIRT228194 BNC2 basonuclin 2 2 2
MIRT237882 WHSC1 nuclear receptor binding SET domain protein 2 2 4
MIRT249021 PABPC3 poly(A) binding protein cytoplasmic 3 2 8
MIRT273958 SPRYD4 SPRY domain containing 4 2 2
MIRT309023 USP53 ubiquitin specific peptidase 53 2 2
MIRT312596 G3BP1 G3BP stress granule assembly factor 1 2 4
MIRT315536 MARCKS myristoylated alanine rich protein kinase C substrate 2 2
MIRT319305 CAV1 caveolin 1 2 2
MIRT324436 TBC1D13 TBC1 domain family member 13 2 2
MIRT325710 CSTF2 cleavage stimulation factor subunit 2 2 2
MIRT340681 THRAP3 thyroid hormone receptor associated protein 3 2 2
MIRT404628 LCOR ligand dependent nuclear receptor corepressor 2 2
MIRT443473 ACPP acid phosphatase, prostate 2 2
MIRT443545 ZNRF2 zinc and ring finger 2 2 2
MIRT446290 RIMKLB ribosomal modification protein rimK like family member B 2 2
MIRT447066 MCC mutated in colorectal cancers 2 2
MIRT447365 RASA2 RAS p21 protein activator 2 2 2
MIRT450079 ZNF354C zinc finger protein 354C 2 2
MIRT454270 PSMA1 proteasome subunit alpha 1 2 2
MIRT456032 CRYZ crystallin zeta 2 8
MIRT462069 CCDC77 coiled-coil domain containing 77 2 4
MIRT466379 TGOLN2 trans-golgi network protein 2 2 4
MIRT470352 PPP2R5E protein phosphatase 2 regulatory subunit B'epsilon 2 2
MIRT471866 NUFIP2 NUFIP2, FMR1 interacting protein 2 2 4
MIRT474453 KLHL11 kelch like family member 11 2 8
MIRT476188 GOLGA8A golgin A8 family member A 2 10
MIRT476645 G2E3 G2/M-phase specific E3 ubiquitin protein ligase 2 2
MIRT481544 ARL10 ADP ribosylation factor like GTPase 10 2 10
MIRT481791 APEX1 apurinic/apyrimidinic endodeoxyribonuclease 1 2 2
MIRT482527 ACTB actin beta 2 4
MIRT485570 FOXQ1 forkhead box Q1 2 2
MIRT486011 LPAR2 lysophosphatidic acid receptor 2 2 2
MIRT495182 MUC20 mucin 20, cell surface associated 2 2
MIRT496047 MORC1 MORC family CW-type zinc finger 1 2 2
MIRT497114 JRKL JRK like 2 2
MIRT497494 RGS17 regulator of G protein signaling 17 2 2
MIRT497752 OXGR1 oxoglutarate receptor 1 2 2
MIRT500217 INHBA inhibin beta A subunit 2 10
MIRT501079 SMAD7 SMAD family member 7 2 8
MIRT501453 PTPN4 protein tyrosine phosphatase, non-receptor type 4 2 8
MIRT502793 CELSR3 cadherin EGF LAG seven-pass G-type receptor 3 2 6
MIRT502879 CDK4 cyclin dependent kinase 4 2 8
MIRT505796 RSBN1 round spermatid basic protein 1 2 8
MIRT506345 NUP54 nucleoporin 54 2 6
MIRT507415 ELK4 ELK4, ETS transcription factor 2 4
MIRT509272 NPM3 nucleophosmin/nucleoplasmin 3 2 6
MIRT514931 TRIM73 tripartite motif containing 73 2 2
MIRT515441 TRIM74 tripartite motif containing 74 2 2
MIRT516026 A1CF APOBEC1 complementation factor 2 2
MIRT517375 CHST6 carbohydrate sulfotransferase 6 2 2
MIRT527925 FRY FRY microtubule binding protein 2 2
MIRT529611 H1F0 H1 histone family member 0 2 2
MIRT530606 C7orf33 chromosome 7 open reading frame 33 2 4
MIRT530970 EXO5 exonuclease 5 2 4
MIRT532108 RRP8 ribosomal RNA processing 8 2 2
MIRT533006 ZFHX3 zinc finger homeobox 3 2 4
MIRT533103 YOD1 YOD1 deubiquitinase 2 2
MIRT533231 VLDLR very low density lipoprotein receptor 2 2
MIRT534073 SRPK1 SRSF protein kinase 1 2 2
MIRT534457 SCML2 Scm polycomb group protein like 2 2 4
MIRT536678 IKZF5 IKAROS family zinc finger 5 2 2
MIRT538224 CYR61 cysteine rich angiogenic inducer 61 2 2
MIRT539218 ANP32E acidic nuclear phosphoprotein 32 family member E 2 4
MIRT541157 PABPC1 poly(A) binding protein cytoplasmic 1 2 4
MIRT552682 YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta 2 2
MIRT554457 SAMD8 sterile alpha motif domain containing 8 2 2
MIRT556688 KLHL28 kelch like family member 28 2 2
MIRT558162 ELAVL2 ELAV like RNA binding protein 2 2 2
MIRT558195 EIF2S1 eukaryotic translation initiation factor 2 subunit alpha 2 4
MIRT558752 CHERP calcium homeostasis endoplasmic reticulum protein 2 2
MIRT561871 MSANTD4 Myb/SANT DNA binding domain containing 4 with coiled-coils 2 2
MIRT567443 GNG12 G protein subunit gamma 12 2 2
MIRT568399 ATF7IP activating transcription factor 7 interacting protein 2 2
MIRT569178 DMD dystrophin 2 2
MIRT571465 CCDC80 coiled-coil domain containing 80 2 2
MIRT575987 Fem1a feminization 1 homolog a (C. elegans) 2 5
MIRT606844 FEM1A fem-1 homolog A 2 7
MIRT615813 COQ7 coenzyme Q7, hydroxylase 2 2
MIRT619491 QSOX2 quiescin sulfhydryl oxidase 2 2 2
MIRT624354 CHRM3 cholinergic receptor muscarinic 3 2 2
MIRT625979 PIK3C2B phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta 2 2
MIRT628564 MELK maternal embryonic leucine zipper kinase 2 2
MIRT631329 CARHSP1 calcium regulated heat stable protein 1 2 2
MIRT639435 PKP1 plakophilin 1 2 2
MIRT640366 C1orf210 chromosome 1 open reading frame 210 2 2
MIRT640701 SKI SKI proto-oncogene 2 2
MIRT640718 CEP68 centrosomal protein 68 2 2
MIRT641217 TRIB1 tribbles pseudokinase 1 2 4
MIRT642271 SMIM17 small integral membrane protein 17 2 2
MIRT644011 PPP1R3G protein phosphatase 1 regulatory subunit 3G 2 2
MIRT645146 CUBN cubilin 2 2
MIRT653158 SPTY2D1 SPT2 chromatin protein domain containing 1 2 2
MIRT654475 RANBP2 RAN binding protein 2 2 2
MIRT656177 MRPL44 mitochondrial ribosomal protein L44 2 2
MIRT658719 ELMOD2 ELMO domain containing 2 2 2
MIRT658857 DTX3L deltex E3 ubiquitin ligase 3L 2 2
MIRT663935 ZNF554 zinc finger protein 554 2 2
MIRT664901 EMC7 ER membrane protein complex subunit 7 2 2
MIRT668801 CYP20A1 cytochrome P450 family 20 subfamily A member 1 2 2
MIRT673514 TNFAIP8L1 TNF alpha induced protein 8 like 1 2 4
MIRT683192 TAF1D TATA-box binding protein associated factor, RNA polymerase I subunit D 2 2
MIRT684049 FOLR1 folate receptor 1 2 2
MIRT685543 PI4K2B phosphatidylinositol 4-kinase type 2 beta 2 2
MIRT690365 RPL37A ribosomal protein L37a 2 2
MIRT691612 IPP intracisternal A particle-promoted polypeptide 2 2
MIRT691651 SLC43A3 solute carrier family 43 member 3 2 2
MIRT694108 ZNF446 zinc finger protein 446 2 2
MIRT695618 VBP1 VHL binding protein 1 2 2
MIRT695925 ZNF174 zinc finger protein 174 2 2
MIRT696445 SUGP1 SURP and G-patch domain containing 1 2 2
MIRT697983 TSPAN6 tetraspanin 6 2 2
MIRT699769 SEMA4D semaphorin 4D 2 2
MIRT702946 HIPK3 homeodomain interacting protein kinase 3 2 2
MIRT703385 GABPB1 GA binding protein transcription factor beta subunit 1 2 2
MIRT704011 EFCAB14 EF-hand calcium binding domain 14 2 2
MIRT704182 DNAJB4 DnaJ heat shock protein family (Hsp40) member B4 2 2
MIRT704446 CTNNB1 catenin beta 1 2 2
MIRT708514 CHCHD3 coiled-coil-helix-coiled-coil-helix domain containing 3 2 2
MIRT713068 ENTHD1 ENTH domain containing 1 2 2
MIRT715799 TBL3 transducin beta like 3 2 2
MIRT716441 RPS24 ribosomal protein S24 2 2
MIRT719421 B4GALNT3 beta-1,4-N-acetyl-galactosaminyltransferase 3 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-3973 Paclitaxel 36314 NSC125973 approved sensitive cell line (A2780)
hsa-miR-3973 Paclitaxel 36314 NSC125973 approved sensitive cell line (A2780)
hsa-miR-3973 Cisplatin 5460033 NSC119875 approved sensitive cell line (A2780)

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