pre-miRNA Information | |
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pre-miRNA | hsa-mir-4742 |
Genomic Coordinates | chr1: 224398227 - 224398311 |
Description | Homo sapiens miR-4742 stem-loop |
Comment | None |
RNA Secondary Structure |
Mature miRNA Information | |||||||||||||||||||||||||
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Mature miRNA | hsa-miR-4742-5p | ||||||||||||||||||||||||
Sequence | 1| UCAGGCAAAGGGAUAUUUACAGA |23 | ||||||||||||||||||||||||
Evidence | Experimental | ||||||||||||||||||||||||
Experiments | Illumina | ||||||||||||||||||||||||
SNPs in miRNA |
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Putative Targets |
Gene Information | |||||||||||||||||||||
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Gene Symbol | TXLNA | ||||||||||||||||||||
Synonyms | IL14, TXLN | ||||||||||||||||||||
Description | taxilin alpha | ||||||||||||||||||||
Transcript | NM_175852 | ||||||||||||||||||||
Expression | |||||||||||||||||||||
Putative miRNA Targets on TXLNA | |||||||||||||||||||||
3'UTR of TXLNA (miRNA target sites are highlighted) |
>TXLNA|NM_175852|3'UTR 1 AGAGCCTGGTGTTGGGTCATGCTGGGAAGGGAGCGGCAGCCCAGCCAGGCCTGGCCCATAAAAGGCTCCCATGCTGAGCA 81 GCCCATTGCTGAAGCCAGGATGTTCTGACCTGGCTGGCATCTGGCACTTGCAATTTTGGATTTTGTGGGTCAGTTTTACG 161 TACATAGGGCATTTTGCAAGGCCTTGCAAATGCATTTATACCTGTAAGTGTACAGTGGGCTTGCATTGGGGATGGGGGTG 241 TGTACAGATGAAGTCAGTGGCTTGTCTGTGAGCTGAAGAGTCTTGAGAGGGGCTGTCATCTGTAGCTGCCATCACAGTGA 321 GTTGGCAGAAGTGACTTGAGCATTTCTCTGTCTGATTTGAGGCTCAGACCCCTCCCTGCCCTTCAGAGCTCAAGACAAGT 401 AATACACCCAGGTCTTGACTGCATTTGTCTTGTGAGCAGGGCTTGCTTGGTCAGCTCAGGCCCTCCTAGCTGCTCTGGAG 481 GCTCCTTTGATTCTCTAGACCTGGAAAAGGTGTCCCTAGGCAGAGCCCTGGCAGGGCGCTCAGAGCTGGGGATTTCCTGC 561 CTGGAACAAGGGACCTGGAGAATGTTTTTGCGTGGGATGATGTGCTGGTCAGGAGCCCCTTGGGCATCGCTTCCCCTGCC 641 CTTTGGTAGTGCCAGGACCAGGCCAATGATGCTTCTCAGTAGCCTTATCATTCACAGGTGCCTCTCTAGCCTGCACAAAT 721 GATTGACAAGAGATCACCCAAAGGATTATTTCTGAAGGTGTTTTTTTCTTTATTTCTTTTTCTTTTTTTTTTTTTTTCTT 801 TTTCTTTTTTTTTTGCACATGACAGTGTTTGTATTGAGGACCTTCCAAGGAAGAGGGATGCTGTAGCAGTGGTGCCTGGG 881 TGCCTGGCCTCCAGTGTCCCACCTCCTTCACCACCCCACTTGGCTCCTTTGCCATCTTGATGCTGAGGTTTCCTGTTTGG 961 TGAGATCAGGTTGTTTGTGGTAAAAGAAAGGAAAGGGCTTCTGATGGCTTTGCCACAAGCTTACCTGTGGGTTTCAGTCC 1041 TGAGAGGCCACCACCAGTTCCCATCAGCACTGTCTCCATGCAGCAGTTGCTGGGTCCCATGTCCAGCTGCCTCTTTGGCT 1121 TCATGGGTTTTTCTGCTTCCTGCCCCCACCCCCACATGTGCAATCCTCAAGATTTGTCCTGATTCTATTTCCTGGCACCT 1201 CCCTGCCTGTCCTTGGGGATTCTACTTCTTCCTGTGTGGGAGCCCATAGCTGTTGTCTAACAGGTAAGAAATGAAATTGA 1281 ACTATTGACTGGGCCCCAGAAATCCATAAAATGGCTGCAGACAGTTGTTTCTGTGTCCTGTTCTACCCCCACTCCAGTAC 1361 ATAACTACTATGTACTGTGTAGAGCCATTCTATATGCTGAATGTTCTGCTGTTGCAAACTTGCCAGGGTATTAGCCAGTG 1441 TTTGTGCCAAGCAGTTTTCTGGGACAACAGAATGACTCAGACCAAGATGGATAGGATGGTTAGGGCTTTGCTTCTTGCTG 1521 TTTTTCTTTGAAGCTAGTTCATTGTCCTGCAGGTCCCTTCATCTTCCATACCTAGCCCACTCTTTTAGCCCTTACCTTAA 1601 ATCTCTCAGATAAGTTGGTTCACAAAGAATGTTAAGTACTGAATCATGTGTGACTGAGACCAGAGATGGCAAATGAATGG 1681 CACACCATTTCTCCTTCTCCTGCCCCAGGGCAGGTACCACTGATCTGCATCAGAGTTGCCTGCTATTCTCTGGTGTATCC 1761 TTCACATCTAGGTGCCCTCAAGCAGCTGTGTGAGTGTTGAGATCTCTGCCATCTCTGGCTGAGATACTGCTGTCCTGTGA 1841 AGTGTTTCCCATGACCTTTTTCTTCCCCTTTGAATCCCTCTGTCTGGAGTAGTCCTTGCCTCTTCCTGCTCCAGTAGGGC 1921 CTTTTCCCTACCCCAGCCCCTGTGCCAGGCTAAGCTGGTACAAGAGCTGCCAACCTCACAGAGTGTTTGCTAGGCGAGAG 2001 AGGTGCAGGGAAGAGGCAGAGGTATGCACCTTCCCCCTTGAAGAGAGGGGAAAGGCCTACAGTGGCCCACATAATTGCCT 2081 GACTCACACTTCAGCTACCTCTTAATGCCTGTGGAGGGACTGGAGCTGCTGGATCCCAGTGTGGTGGTGTAGGAGGCCAC 2161 AGTGAGCAGGTGGCCCCAGCTGGGTTTCCCAGGTCAGGAATGTGGGCCCCAGGCAAGGTGCAGCCTTTGCTCACAGCTCC 2241 ATCCATGTCTAGACCTTCAGGCCAGTCTGCAGATGAGGTTCCCTACCTTTTTCTTCTCTTCATTGACCAAATCAACCAAT 2321 CACTACAGCTGCTCTGCTTCTGCTTTCCAAAGTAGCCCAGGTCCTGGGCCAGATGCAGGGGAGGTGCCTATCCATGAGTG 2401 AAGGCCAGTGTCTTCCTCACCTGGGTGGGTCCCACACTTGTGACCTCAGTTTTAGGACCAAGATCTGTGTTGGTTTCTTA 2481 GATTGCTAGCTTTTCCTCCAGGGGACCACAGCAGGTGAAGCTCAAGAGCGCATGGCTCTGCTAATAGTAAATTGTTTTCA 2561 GGGCCTTGTCCAGCTGAGAGCTTCATGTCCACCAGATTCTGAGAGGTGTCAGCAGCACTTTTTTTTTTTATTTGTTGTTT 2641 GTTTTCCATGAGGTTATCGGACCATGGGCTGAGCTCAGGCACTTTCTGTAGGAGACTGTTATTTCTGTAAAGATGGTTAT 2721 TTAACCCTCCTCCACCCCATCACGGTGGCCCTGAGGGCTGACCCGGAGGCCAGTGGAGCTGCCTGGTGTCCACGGGGGAG 2801 GGCCAAGGCCTGCTGAGCTGATTCTCCAGCTGCTGCCCCAGCCTTTCCGCCTTGCACAGCACAGAGGTGGTCACCCCAGG 2881 GACAGCCAGGCACCTGCTCCTCTTGCCCTTCCTGGGGGAAGGGAGCTGCCTTCTGTCCCTGTAACTGCTTTCCTTATGGC 2961 CCAGCCCGGCCACTCAGACTTGTTTGAAGCTGCACTGGCAGCTTTTTTGTCTCCTTTGGGTATTCACAACAGCCAGGGAC 3041 TTGATTTTGATGTATTTTAAACCACATTAAATAAAGAGTCTGTTGCCTTAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA 3121 AAAAAAAAAAAAAAAAA Target sites
Provided by authors
Predicted by miRanda
DRVs
SNPs
DRVs & SNPs
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miRNA-target interactions (Predicted by miRanda) |
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DRVs in gene 3'UTRs | |||||||||||||||||||||
SNPs in gene 3'UTRs |
Experimental Support 1 for Functional miRNA-Target Interaction | |||||||
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miRNA:Target | ---- | ||||||
Validation Method |
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Conditions | HEK293 | ||||||
Disease | 200081.0 | ||||||
Location of target site | 3'UTR | ||||||
Tools used in this research | TargetScan , miRTarCLIP , Piranha | ||||||
Original Description (Extracted from the article) |
...
"PAR-CLIP data was present in GSM714644. RNA binding protein: AGO2. Condition:completeT1
... - Kishore S; Jaskiewicz L; Burger L; Hausser et al., 2011, Nature methods. |
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miRNA-target interactions (Provided by authors) |
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Article |
- Kishore S; Jaskiewicz L; Burger L; Hausser et al. - Nature methods, 2011
Cross-linking and immunoprecipitation (CLIP) is increasingly used to map transcriptome-wide binding sites of RNA-binding proteins. We developed a method for CLIP data analysis, and applied it to compare CLIP with photoactivatable ribonucleoside-enhanced CLIP (PAR-CLIP) and to uncover how differences in cross-linking and ribonuclease digestion affect the identified sites. We found only small differences in accuracies of these methods in identifying binding sites of HuR, which binds low-complexity sequences, and Argonaute 2, which has a complex binding specificity. We found that cross-link-induced mutations led to single-nucleotide resolution for both PAR-CLIP and CLIP. Our results confirm the expectation from original CLIP publications that RNA-binding proteins do not protect their binding sites sufficiently under the denaturing conditions used during the CLIP procedure, and we show that extensive digestion with sequence-specific RNases strongly biases the recovered binding sites. This bias can be substantially reduced by milder nuclease digestion conditions.
LinkOut: [PMID: 21572407]
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CLIP-seq Support 1 for dataset GSM4903833 | |
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Method / RBP | HITS-CLIP / AGO |
Cell line / Condition | Dermal fibroblasts / CTL_TD_21_a |
Location of target site | NM_175852 | 3UTR | GUACCACUGAUCUGCAUCAGAGUUGCCUGCUAUUCUCUGGUGUAUCCUUCACAUCUAGGUGCCCUCAAGCAGCU |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Accession Series | GSE161239 |
CLIP-seq Viewer | Link |
CLIP-seq Support 2 for dataset GSM4903838 | |
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Method / RBP | HITS-CLIP / AGO |
Cell line / Condition | Dermal fibroblasts / 124_TD_21_c |
Location of target site | NM_175852 | 3UTR | UCCUUCUCCUGCCCCAGGGCAGGUACCACUGAUCUGCAUCAGAGUUGCCUGCUAUUCUCUGGUGUAUCCUUCACAUCUAGGUGCCCUCAAGCAGCU |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Accession Series | GSE161239 |
CLIP-seq Viewer | Link |
CLIP-seq Support 3 for dataset GSM714644 | |
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Method / RBP | PAR-CLIP / AGO2 |
Cell line / Condition | HEK293 / completeT1, repA |
Location of target site | ENST00000373610.3 | 3UTR | UAAUUGCCUGACUCACACUUCAGCUACCUCUUAAUG |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Article / Accession Series | PMID: 21572407 / GSE28865 |
CLIP-seq Viewer | Link |
MiRNA-Target Expression Profile | |||||||
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MiRNA-Target Expression Profile (TCGA) | |||||||
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70 hsa-miR-4742-5p Target Genes:
Functional analysis:
ID | Target | Description | Validation methods | |||||||||
Strong evidence | Less strong evidence | |||||||||||
MIRT065632 | CLIC4 | chloride intracellular channel 4 | 2 | 4 | ||||||||
MIRT068170 | TXLNA | taxilin alpha | 2 | 2 | ||||||||
MIRT119024 | TSN | translin | 2 | 2 | ||||||||
MIRT165212 | GRAMD3 | GRAM domain containing 2B | 2 | 2 | ||||||||
MIRT175254 | PSAT1 | phosphoserine aminotransferase 1 | 2 | 4 | ||||||||
MIRT213228 | REST | RE1 silencing transcription factor | 2 | 6 | ||||||||
MIRT296337 | PARD6B | par-6 family cell polarity regulator beta | 2 | 2 | ||||||||
MIRT316776 | FOXC1 | forkhead box C1 | 2 | 2 | ||||||||
MIRT453943 | XRCC6 | X-ray repair cross complementing 6 | 2 | 6 | ||||||||
MIRT454599 | RPL13A | ribosomal protein L13a | 2 | 2 | ||||||||
MIRT458485 | RMI1 | RecQ mediated genome instability 1 | 2 | 6 | ||||||||
MIRT458650 | SGPP2 | sphingosine-1-phosphate phosphatase 2 | 2 | 2 | ||||||||
MIRT459240 | ADRBK1 | G protein-coupled receptor kinase 2 | 2 | 2 | ||||||||
MIRT461008 | SYT7 | synaptotagmin 7 | 2 | 2 | ||||||||
MIRT462026 | RIF1 | replication timing regulatory factor 1 | 2 | 2 | ||||||||
MIRT462103 | TMEM214 | transmembrane protein 214 | 2 | 2 | ||||||||
MIRT463255 | ZIC5 | Zic family member 5 | 2 | 4 | ||||||||
MIRT465190 | TRPS1 | transcriptional repressor GATA binding 1 | 2 | 2 | ||||||||
MIRT470507 | PPP1R11 | protein phosphatase 1 regulatory inhibitor subunit 11 | 2 | 2 | ||||||||
MIRT472356 | TSPAN1 | tetraspanin 1 | 2 | 2 | ||||||||
MIRT473260 | MIDN | midnolin | 2 | 2 | ||||||||
MIRT477527 | EIF4G2 | eukaryotic translation initiation factor 4 gamma 2 | 2 | 4 | ||||||||
MIRT485182 | PTP4A1 | protein tyrosine phosphatase type IVA, member 1 | 2 | 4 | ||||||||
MIRT486461 | MDM2 | MDM2 proto-oncogene | 2 | 2 | ||||||||
MIRT492760 | PER1 | period circadian clock 1 | 2 | 8 | ||||||||
MIRT496703 | TRIM39 | tripartite motif containing 39 | 2 | 2 | ||||||||
MIRT497227 | MORC2 | MORC family CW-type zinc finger 2 | 2 | 2 | ||||||||
MIRT499582 | INTU | inturned planar cell polarity protein | 2 | 4 | ||||||||
MIRT504081 | C9orf40 | chromosome 9 open reading frame 40 | 2 | 6 | ||||||||
MIRT505484 | SRSF2 | serine and arginine rich splicing factor 2 | 2 | 2 | ||||||||
MIRT513255 | FBXO17 | F-box protein 17 | 2 | 2 | ||||||||
MIRT525061 | FRK | fyn related Src family tyrosine kinase | 2 | 2 | ||||||||
MIRT528798 | RAB32 | RAB32, member RAS oncogene family | 2 | 2 | ||||||||
MIRT534357 | SFT2D2 | SFT2 domain containing 2 | 2 | 2 | ||||||||
MIRT538731 | CAPN1 | calpain 1 | 2 | 2 | ||||||||
MIRT550792 | WARS2 | tryptophanyl tRNA synthetase 2, mitochondrial | 2 | 2 | ||||||||
MIRT553994 | SRPR | SRP receptor alpha subunit | 2 | 4 | ||||||||
MIRT568102 | CDKN1B | cyclin dependent kinase inhibitor 1B | 2 | 2 | ||||||||
MIRT570107 | SLC18B1 | solute carrier family 18 member B1 | 2 | 2 | ||||||||
MIRT570823 | RPL7L1 | ribosomal protein L7 like 1 | 2 | 2 | ||||||||
MIRT572004 | HMGB1 | high mobility group box 1 | 2 | 2 | ||||||||
MIRT572352 | PCYT2 | phosphate cytidylyltransferase 2, ethanolamine | 2 | 2 | ||||||||
MIRT609716 | TMEM132C | transmembrane protein 132C | 2 | 2 | ||||||||
MIRT613982 | LRRC40 | leucine rich repeat containing 40 | 2 | 2 | ||||||||
MIRT620740 | CCL16 | C-C motif chemokine ligand 16 | 2 | 2 | ||||||||
MIRT625074 | C15orf41 | chromosome 15 open reading frame 41 | 2 | 4 | ||||||||
MIRT627941 | NNT | nicotinamide nucleotide transhydrogenase | 2 | 2 | ||||||||
MIRT629941 | IGSF6 | immunoglobulin superfamily member 6 | 2 | 2 | ||||||||
MIRT633396 | FBXW8 | F-box and WD repeat domain containing 8 | 2 | 2 | ||||||||
MIRT635846 | ZNF264 | zinc finger protein 264 | 2 | 2 | ||||||||
MIRT638086 | ZNF652 | zinc finger protein 652 | 2 | 2 | ||||||||
MIRT643996 | TCHP | trichoplein keratin filament binding | 2 | 2 | ||||||||
MIRT660020 | C1GALT1 | core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 | 2 | 2 | ||||||||
MIRT660161 | BRCC3 | BRCA1/BRCA2-containing complex subunit 3 | 2 | 2 | ||||||||
MIRT668887 | CSRP1 | cysteine and glycine rich protein 1 | 2 | 2 | ||||||||
MIRT676729 | METTL14 | methyltransferase like 14 | 2 | 2 | ||||||||
MIRT677210 | MURC | caveolae associated protein 4 | 2 | 2 | ||||||||
MIRT685949 | PTGIS | prostaglandin I2 synthase | 2 | 2 | ||||||||
MIRT687816 | ITPRIPL2 | inositol 1,4,5-trisphosphate receptor interacting protein like 2 | 2 | 2 | ||||||||
MIRT689900 | SOD2 | superoxide dismutase 2 | 2 | 2 | ||||||||
MIRT698214 | TMEM248 | transmembrane protein 248 | 2 | 2 | ||||||||
MIRT698279 | TMEM2 | transmembrane protein 2 | 2 | 2 | ||||||||
MIRT698758 | STK4 | serine/threonine kinase 4 | 2 | 2 | ||||||||
MIRT698789 | STK38 | serine/threonine kinase 38 | 2 | 2 | ||||||||
MIRT703152 | GPR137C | G protein-coupled receptor 137C | 2 | 2 | ||||||||
MIRT704408 | CTPS1 | CTP synthase 1 | 2 | 2 | ||||||||
MIRT705067 | C4orf32 | family with sequence similarity 241 member A | 2 | 2 | ||||||||
MIRT710201 | FLVCR1 | feline leukemia virus subgroup C cellular receptor 1 | 2 | 2 | ||||||||
MIRT714495 | HSPA4 | heat shock protein family A (Hsp70) member 4 | 2 | 2 | ||||||||
MIRT720082 | TNRC6B | trinucleotide repeat containing 6B | 2 | 2 |
miRNA-Drug Resistance Associations | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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