miRTarBase - #MIRT070247


—
pre-miRNA Information
pre-miRNA hsa-mir-5197   
Genomic Coordinates chr5: 143679860 - 143679971
Description Homo sapiens miR-5197 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-5197-3p
Sequence 64| AAGAAGAGACUGAGUCAUCGAAU |86
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs77549240 8 dbSNP
rs1411653302 10 dbSNP
rs1347866830 14 dbSNP
rs892818585 19 dbSNP
rs1405555825 20 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol FRMD6   
Synonyms C14orf31, EX1, Willin, c14_5320
Description FERM domain containing 6
Transcript NM_001042481   
Other Transcripts NM_152330   
Expression
Putative miRNA Targets on FRMD6
3'UTR of FRMD6
(miRNA target sites are highlighted)		 
>FRMD6|NM_001042481|3'UTR
   1 AGTCCGTCTGTGTGCAGCTGTACAGGCAGCTTACTGTTTGCTAGAGGATGCGAAAGTCATAAGTTCTTTACATATTACTT
  81 GTGCCATATCTTCTTCACCCTAAACATAGCTCTTTCTTTATAATATTTGTGATGATGGAAACAAAAGCCTTGGAACAATT
 161 GCACTTTAAGTATTACACAGAAGTAAAAGAACTACAGAAAATGTACAGCAAGACAAGTGCCCGGAAGTTCACTGATCCTT
 241 CAGAAGGAAATGCGCTTTACTGATTGCAAAGCCTTCAGAATATTGGAGTGTGGTGTGTTTGCTCATCTGATGCTTTTTAG
 321 TTCAGTTACATGTAACATCACATTTTTTTATCACGTGAAAGATGTTAGATTTGTTTGCTTATAAATTTTTTACCACTCCC
 401 ACATAAAATGCTCATAGTTTGGGAGAGGAAAGAGGGAAGATTCTCTCTTCTTTTAACAGAGAGATGATTGCTCTGTATAC
 481 CCATTGCTTCCTCCCTGAGGCTGTCCCAAAGTGAACACTGATGGAGTGGTCAAAATCATAAGGTTGTAGCAAGCCAAAGA
 561 TACGTATGTGACAGAAGCACATAAGCAATAAGCAGAAAACCAGAAGTGCATGCTGTGATGCCTGTGACTCCTTCATCCCG
 641 CTCAGTGCCATGTCCTCTTTTGTGATCTTCCAGAAAGCTCCAGGATTCATTTGAGTTCCACATCCAAGTAACAGATGAAT
 721 TATATTCATGTTGTAATGCATTTTGTGGAGTTTACAAAACCAGTGTCTGTTAAAACTTTGGAAAATGTCTTAGAAAACGT
 801 TGGTGCTTGGTGATGCTTTATTTGTTTAATTATCAAGAACAAATTATGGCAATGCTAGTTTCTGCTTAACCAAAATACTC
 881 TGTGTATATATTATACATATATAAATACATGGGATTGTGTATGTCTATATGTGTTTAAAGCTTACTATGTCTTCATTTTG
 961 GCTTCCATGACTATCTTTTATACATGGAATTCCTTAAGATTGAGAATATGTCACTGAGTGAATGATACCTGCAGACAGTC
1041 AGTTGATATATGTAGAGTTCAGAATGACTGTTTTCTCATGTGCCTTTGGCCATGATTCTCAACACTGATTGTATAACAGA
1121 ATTTTGGGGGGAGCTTTTAAAAAATAATGACTGAGTCTCCCACCAGACCGATTACATCATTCTCTTGTGGCGGGACCCAA
1201 GTAGAATTGCCTTTTCTTTTAAAGTTCTCCAGATGGAGCTAATATGCAACAAAGTTGAAAACCACTGATCCTGGGGGTGT
1281 CTTGTTAATTTTGAAGTAAAAGTGTACAGAAGACGTAGTGTATGAGAAAGGGCCATTTTTAAGACAGTTACCTGTTGTGC
1361 TGCTGTTACAATATATAATGAAACCAAGTCAGGGGAGTGAATTTATCAATCTTTTGATGTAAAGTAAAAACGTAGTTCAC
1441 ACTTCAGGAGAGAACTTCATAGCACAATGTCTTTCTATAAGATATTTTTAATGATTTAGTATTTTACAACATTTGTTTAC
1521 CATATTTTGATATACCATTTTTTTCTATCTGCCCAGTTTTATTAAAAAAACTATATATTATTTTCTAAAGAAACAATCAT
1601 ATTTTTATACAAAATTATGTTTTCAGGTAACGAAATAGATGTAGGGTACAGTGGAACATAAGCAGTGTTACCCCTGGCTG
1681 GGAGTCAGTATTATACAACAAATGGTGAGCTGGAACATGCCCTGTCTGTGCTGTCCCTCCTGTGCTGGGTCGCGGATGTG
1761 TAGGCAACATTGCCTTATCACGCTAGGTTCACCTGACACTTTAAAAGGAAAAAAAGTTCCATAGAGTTCTGTGGTCACAA
1841 AATTGTTTTGCTTTTATCAAATACTTTAATAGAACCAAAGTTGCAGATATTGGAATGTATGGAAGTATCTCAGTCTCTGC
1921 ATAAGAGGATTAAAGTATGAAAGGATCATTTAATGACTGTTTTACTTATAAGTCATTAAGTAATCCACCATTTCTTATGG
2001 ATGATGCTTAAGCCTGGTGAGGTTTGTACTCTAAGGAGCCCAGATCATAATGCAGTGCATTTCCTTAGCCCTTAGAGTTT
2081 CTTGCAAACATTTAAAAAAAGACATATTTAAGAAAGAAAGATAAAGAAAAAACATATTTAATTACTGTAAACAGGTACTG
2161 CTTTATGTTTATTTTCTCTCTACTTCAACCAAAATCAGATCTTTGAGGTTTTGCTGACATTGTTGGTGGTTTTGCACATG
2241 TTCTTTCTAATTGGATTTATGAATAGTTCTATGGGTTTTCAAAGATGAATCATGCTAAGAACACTTCTGCTTTTTGATCC
2321 ACTGTTTGCAGCAGAATTATATATATGTATAGGAAAAATCCACTTTGAATAATCCATGTTTTGTATTTGGAAATTGTTTT
2401 TAAAAATAAAAAGGAAAGGAAATATATAAAGCTGTTATTTATTCTGCATTTCTTACATATCTATCGCTTGTCAGTATACC
2481 CGTTTTGGTATATATTGCCTCTGCACATCTACATTTGTATATGCAACAGTGAGCTTTATATCTACATAAACTGTAAATAA
2561 TCCTTTCTGTGAAAGGATCATCATATCAAGATGATACCAAAAGTATGTAAAAAGAAACCTGCATTATTTTGTAATTATTT
2641 CTTATAGATATTTCATGGTAAGATTAGCAGTCAATAAAGTTACTTTTTTGCCTTTAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' uaagCUACUGAGUCAGAGAAGAa 5'
              || ||:||  |||||||| 
Target 5' gaggGAAGATTC--TCTCTTCTt 3'
 432 - 452 163.00 -15.30
2 
miRNA  3' uaaGCUACUG-AGUCAGAGAAGAa 5'
             |||| || ||| |||||| | 
Target 5' gacCGATTACATCATTCTCTTGTg 3'
 1166 - 1189 144.00 -13.60
3 
miRNA  3' uaAGCUACUGAGUCAGAGAAGAa 5'
            || :|| | ::  |||||:| 
Target 5' gcTCAGTGCCATGTCCTCTTTTg 3'
 640 - 662 137.00 -11.30
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30538809 5 COSMIC
COSN31510694 35 COSMIC
COSN26976751 52 COSMIC
COSN30492387 63 COSMIC
COSN30101948 67 COSMIC
COSN5387352 89 COSMIC
COSN30116284 99 COSMIC
COSN31535532 103 COSMIC
COSN25264940 223 COSMIC
COSN31611198 234 COSMIC
COSN17705660 349 COSMIC
COSN20111258 350 COSMIC
COSN22537598 369 COSMIC
COSN32064504 414 COSMIC
COSN31480080 446 COSMIC
COSN1653404 460 COSMIC
COSN7236382 483 COSMIC
COSN31480075 532 COSMIC
COSN17965383 544 COSMIC
COSN26571470 574 COSMIC
COSN31480094 644 COSMIC
COSN28788832 649 COSMIC
COSN21980788 796 COSMIC
COSN23839546 1188 COSMIC
COSN17454963 1222 COSMIC
COSN22237821 1233 COSMIC
COSN31597084 1315 COSMIC
COSN31553569 1316 COSMIC
COSN30177042 1325 COSMIC
COSN26584970 1366 COSMIC
COSN30538598 1391 COSMIC
COSN31513642 1545 COSMIC
COSN25427576 1565 COSMIC
COSN31577358 1571 COSMIC
COSN6253283 1598 COSMIC
COSN31537953 1692 COSMIC
COSN24653850 1708 COSMIC
COSN30544602 2013 COSMIC
COSN29314092 2353 COSMIC
COSN23714614 2370 COSMIC
COSN31596377 2472 COSMIC
COSN5387353 2479 COSMIC
COSN31527871 2568 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs769555375 6 dbSNP
rs375396408 7 dbSNP
rs369157465 9 dbSNP
rs1006320373 10 dbSNP
rs1176329719 11 dbSNP
rs757241871 12 dbSNP
rs778661218 13 dbSNP
rs750238716 15 dbSNP
rs1341479694 20 dbSNP
rs758189152 36 dbSNP
rs781455318 37 dbSNP
rs1018483251 39 dbSNP
rs748334240 44 dbSNP
rs374771129 52 dbSNP
rs777928146 53 dbSNP
rs1298760396 58 dbSNP
rs773128955 60 dbSNP
rs1490310266 67 dbSNP
rs1198139412 70 dbSNP
rs1479695311 75 dbSNP
rs1250866670 76 dbSNP
rs977060548 82 dbSNP
rs3742542 87 dbSNP
rs996366048 89 dbSNP
rs1028027791 91 dbSNP
rs1222682375 95 dbSNP
rs762645145 97 dbSNP
rs1350975755 111 dbSNP
rs983171686 112 dbSNP
rs907634400 113 dbSNP
rs1389672991 134 dbSNP
rs766759942 150 dbSNP
rs1302973353 154 dbSNP
rs1037938810 157 dbSNP
rs113205157 163 dbSNP
rs575109418 164 dbSNP
rs1465948294 165 dbSNP
rs1480306505 167 dbSNP
rs1188857338 168 dbSNP
rs774742989 169 dbSNP
rs759780350 170 dbSNP
rs955870155 171 dbSNP
rs990010028 179 dbSNP
rs927185721 184 dbSNP
rs1462768970 191 dbSNP
rs1252137270 195 dbSNP
rs1203343933 202 dbSNP
rs914389291 203 dbSNP
rs111955691 204 dbSNP
rs544536918 210 dbSNP
rs1057063980 211 dbSNP
rs1200745608 217 dbSNP
rs35354191 220 dbSNP
rs895791235 223 dbSNP
rs564429565 224 dbSNP
rs1041742848 228 dbSNP
rs1335669391 229 dbSNP
rs904613369 238 dbSNP
rs147692126 251 dbSNP
rs181655937 254 dbSNP
rs1160673432 255 dbSNP
rs566413625 270 dbSNP
rs1452210198 276 dbSNP
rs535327768 289 dbSNP
rs1363731049 292 dbSNP
rs907924125 296 dbSNP
rs1446511602 303 dbSNP
rs1158027571 305 dbSNP
rs1183196175 308 dbSNP
rs1465553761 310 dbSNP
rs756711168 321 dbSNP
rs1203198266 329 dbSNP
rs964268502 332 dbSNP
rs1386599081 336 dbSNP
rs1356603235 337 dbSNP
rs11426856 343 dbSNP
rs397844286 343 dbSNP
rs577864653 343 dbSNP
rs1435298547 345 dbSNP
rs998821728 350 dbSNP
rs764494443 355 dbSNP
rs1029933965 356 dbSNP
rs996418624 358 dbSNP
rs1164341301 365 dbSNP
rs183901281 384 dbSNP
rs1370535105 385 dbSNP
rs1385395761 386 dbSNP
rs1383442236 390 dbSNP
rs149192990 395 dbSNP
rs890815039 396 dbSNP
rs1375008137 399 dbSNP
rs983119555 400 dbSNP
rs567379496 422 dbSNP
rs1446208305 432 dbSNP
rs543610783 444 dbSNP
rs1224599965 452 dbSNP
rs1489844741 453 dbSNP
rs540380602 462 dbSNP
rs1228498898 464 dbSNP
rs1031321371 468 dbSNP
rs1268034930 469 dbSNP
rs1226326528 476 dbSNP
rs955796924 478 dbSNP
rs1324682037 492 dbSNP
rs963118471 494 dbSNP
rs1407242232 495 dbSNP
rs973209294 498 dbSNP
rs1330671999 501 dbSNP
rs189671210 501 dbSNP
rs34982464 505 dbSNP
rs1021499721 507 dbSNP
rs1430502116 514 dbSNP
rs754276534 518 dbSNP
rs1166337087 520 dbSNP
rs927094072 522 dbSNP
rs573624442 525 dbSNP
rs1201352627 527 dbSNP
rs11544525 533 dbSNP
rs937201695 539 dbSNP
rs180734826 541 dbSNP
rs7150275 544 dbSNP
rs946005545 547 dbSNP
rs1439041115 548 dbSNP
rs1270327993 549 dbSNP
rs528408378 564 dbSNP
rs1345311419 572 dbSNP
rs1284285131 573 dbSNP
rs7149810 574 dbSNP
rs564798436 577 dbSNP
rs143321378 578 dbSNP
rs904561147 586 dbSNP
rs1443610628 591 dbSNP
rs907864170 593 dbSNP
rs1326956772 600 dbSNP
rs1000670426 602 dbSNP
rs1418400181 607 dbSNP
rs942160102 610 dbSNP
rs1039808662 618 dbSNP
rs1473574695 623 dbSNP
rs922111490 624 dbSNP
rs35468904 631 dbSNP
rs72186768 631 dbSNP
rs757391479 631 dbSNP
rs1471149732 632 dbSNP
rs1160102890 639 dbSNP
rs899971394 640 dbSNP
rs550473885 641 dbSNP
rs1295617699 642 dbSNP
rs148381485 648 dbSNP
rs754566915 650 dbSNP
rs1029881701 656 dbSNP
rs887355870 663 dbSNP
rs1004503722 666 dbSNP
rs1014587923 671 dbSNP
rs963102939 674 dbSNP
rs1262962547 683 dbSNP
rs780689424 685 dbSNP
rs1376204343 686 dbSNP
rs1277779639 687 dbSNP
rs1228414859 689 dbSNP
rs1383692258 692 dbSNP
rs1338937416 697 dbSNP
rs891458065 706 dbSNP
rs1034107243 707 dbSNP
rs185990932 709 dbSNP
rs1021342697 736 dbSNP
rs992613975 751 dbSNP
rs917120798 756 dbSNP
rs549401207 770 dbSNP
rs1001747889 772 dbSNP
rs566078951 778 dbSNP
rs1480221133 782 dbSNP
rs115864239 799 dbSNP
rs960253684 800 dbSNP
rs1253811680 803 dbSNP
rs552111212 810 dbSNP
rs1319188854 814 dbSNP
rs1282749992 817 dbSNP
rs1223780097 821 dbSNP
rs374820802 823 dbSNP
rs1360221416 836 dbSNP
rs1182937662 837 dbSNP
rs1413211206 841 dbSNP
rs370312002 846 dbSNP
rs1040153544 851 dbSNP
rs1167242947 855 dbSNP
rs1450664600 856 dbSNP
rs899921145 858 dbSNP
rs769831265 863 dbSNP
rs1289164505 867 dbSNP
rs1432655763 871 dbSNP
rs1051260546 873 dbSNP
rs1317556274 881 dbSNP
rs116289056 887 dbSNP
rs1004453225 891 dbSNP
rs1017218309 894 dbSNP
rs1390412738 906 dbSNP
rs898789411 915 dbSNP
rs192094869 918 dbSNP
rs973477299 930 dbSNP
rs921991424 931 dbSNP
rs1311713289 934 dbSNP
rs1376402806 935 dbSNP
rs780275997 941 dbSNP
rs1229664929 946 dbSNP
rs1313073331 955 dbSNP
rs1243882738 962 dbSNP
rs1034466136 974 dbSNP
rs958480853 976 dbSNP
rs1359575438 978 dbSNP
rs932071309 985 dbSNP
rs988067931 990 dbSNP
rs557249394 1007 dbSNP
rs1300677830 1011 dbSNP
rs1423437553 1015 dbSNP
rs1320235837 1030 dbSNP
rs1172044503 1035 dbSNP
rs1417756284 1036 dbSNP
rs549132975 1036 dbSNP
rs1193439532 1040 dbSNP
rs1481014114 1048 dbSNP
rs1271700384 1049 dbSNP
rs1220978542 1050 dbSNP
rs368245298 1060 dbSNP
rs1252008686 1062 dbSNP
rs1052665695 1066 dbSNP
rs1306013642 1074 dbSNP
rs749206855 1075 dbSNP
rs967197258 1076 dbSNP
rs1347226470 1078 dbSNP
rs947014906 1080 dbSNP
rs1404296538 1092 dbSNP
rs1042844009 1093 dbSNP
rs200846457 1101 dbSNP
rs1257054540 1106 dbSNP
rs925895285 1109 dbSNP
rs115284553 1110 dbSNP
rs1167060816 1114 dbSNP
rs770868284 1118 dbSNP
rs1392462073 1126 dbSNP
rs1431989165 1126 dbSNP
rs1197857383 1128 dbSNP
rs975430895 1144 dbSNP
rs921301973 1146 dbSNP
rs895643600 1148 dbSNP
rs1176051249 1160 dbSNP
rs1005215887 1166 dbSNP
rs35992978 1166 dbSNP
rs1250952341 1167 dbSNP
rs1014755615 1170 dbSNP
rs934043530 1171 dbSNP
rs552595406 1179 dbSNP
rs1222774004 1188 dbSNP
rs572507119 1192 dbSNP
rs931190597 1222 dbSNP
rs1360790554 1223 dbSNP
rs774226042 1224 dbSNP
rs750052898 1225 dbSNP
rs544571585 1233 dbSNP
rs1336978197 1239 dbSNP
rs1365730125 1241 dbSNP
rs1028931919 1248 dbSNP
rs564859714 1249 dbSNP
rs1408732433 1250 dbSNP
rs953626053 1263 dbSNP
rs887242734 1271 dbSNP
rs1364892211 1273 dbSNP
rs1161987294 1274 dbSNP
rs1417392553 1278 dbSNP
rs1237687275 1294 dbSNP
rs759837364 1297 dbSNP
rs987564133 1300 dbSNP
rs940176541 1305 dbSNP
rs1240997215 1307 dbSNP
rs1038599283 1316 dbSNP
rs140589627 1319 dbSNP
rs1262409675 1321 dbSNP
rs767847151 1328 dbSNP
rs1315782725 1348 dbSNP
rs1315206300 1349 dbSNP
rs1212274772 1352 dbSNP
rs1380125809 1355 dbSNP
rs1335069007 1359 dbSNP
rs72675849 1369 dbSNP
rs894162434 1374 dbSNP
rs988408512 1378 dbSNP
rs1013930658 1379 dbSNP
rs1282995303 1391 dbSNP
rs915470451 1391 dbSNP
rs946941320 1412 dbSNP
rs1042769060 1415 dbSNP
rs145878487 1422 dbSNP
rs1383632828 1426 dbSNP
rs1187177588 1432 dbSNP
rs755714083 1433 dbSNP
rs1263638099 1442 dbSNP
rs1203293508 1446 dbSNP
rs1487936263 1454 dbSNP
rs1056849763 1459 dbSNP
rs998652228 1460 dbSNP
rs181913038 1478 dbSNP
rs549504629 1495 dbSNP
rs1327365905 1506 dbSNP
rs975757236 1512 dbSNP
rs1380983337 1515 dbSNP
rs1360458532 1516 dbSNP
rs1376308641 1524 dbSNP
rs994709048 1528 dbSNP
rs1028982802 1529 dbSNP
rs1363863269 1534 dbSNP
rs137902138 1535 dbSNP
rs74054411 1537 dbSNP
rs1365475962 1538 dbSNP
rs1374536177 1546 dbSNP
rs1019002748 1548 dbSNP
rs957108589 1550 dbSNP
rs988339756 1553 dbSNP
rs112049431 1554 dbSNP
rs1288588587 1557 dbSNP
rs968330174 1558 dbSNP
rs1341075626 1562 dbSNP
rs1219787389 1564 dbSNP
rs878903573 1564 dbSNP
rs908637420 1565 dbSNP
rs926960904 1567 dbSNP
rs186556712 1571 dbSNP
rs1343698587 1572 dbSNP
rs1407348256 1572 dbSNP
rs1323000554 1573 dbSNP
rs1328650608 1574 dbSNP
rs1207055076 1576 dbSNP
rs1410707322 1578 dbSNP
rs1398921437 1579 dbSNP
rs1166428512 1583 dbSNP
rs190567770 1588 dbSNP
rs551196560 1600 dbSNP
rs1429781837 1601 dbSNP
rs1465531075 1602 dbSNP
rs917033788 1609 dbSNP
rs1245582246 1612 dbSNP
rs1221243994 1618 dbSNP
rs1245384433 1619 dbSNP
rs1439136242 1624 dbSNP
rs754336066 1632 dbSNP
rs567753390 1633 dbSNP
rs757714763 1641 dbSNP
rs1264201923 1644 dbSNP
rs879178549 1647 dbSNP
rs1471284375 1650 dbSNP
rs1160757154 1655 dbSNP
rs1388858280 1662 dbSNP
rs1225841651 1671 dbSNP
rs1343535506 1673 dbSNP
rs1274265262 1674 dbSNP
rs1036191377 1688 dbSNP
rs894117940 1689 dbSNP
rs1329520977 1698 dbSNP
rs1013878603 1706 dbSNP
rs536805808 1708 dbSNP
rs902932546 1713 dbSNP
rs998599844 1714 dbSNP
rs1178359958 1723 dbSNP
rs1468104751 1724 dbSNP
rs780352389 1726 dbSNP
rs1348562911 1732 dbSNP
rs1050321683 1746 dbSNP
rs552667256 1752 dbSNP
rs1032825452 1753 dbSNP
rs1290324830 1754 dbSNP
rs145970398 1755 dbSNP
rs66677264 1759 dbSNP
rs1205976300 1762 dbSNP
rs1441103064 1765 dbSNP
rs553729736 1774 dbSNP
rs558115571 1782 dbSNP
rs955327371 1783 dbSNP
rs986793522 1790 dbSNP
rs956838069 1793 dbSNP
rs550937559 1798 dbSNP
rs750720662 1800 dbSNP
rs1022506760 1808 dbSNP
rs1251651518 1809 dbSNP
rs961436894 1810 dbSNP
rs1358432467 1819 dbSNP
rs1318853975 1820 dbSNP
rs974593301 1822 dbSNP
rs1183666474 1825 dbSNP
rs1377897741 1826 dbSNP
rs575538191 1827 dbSNP
rs1444798916 1840 dbSNP
rs1472250466 1841 dbSNP
rs544179498 1854 dbSNP
rs554803853 1859 dbSNP
rs1181438505 1865 dbSNP
rs1471995144 1869 dbSNP
rs1237311619 1876 dbSNP
rs926872165 1878 dbSNP
rs961233570 1881 dbSNP
rs992530490 1897 dbSNP
rs780813933 1900 dbSNP
rs1415692358 1901 dbSNP
rs918176701 1906 dbSNP
rs1360333941 1907 dbSNP
rs746165422 1910 dbSNP
rs573257329 1916 dbSNP
rs1317423757 1928 dbSNP
rs916898155 1934 dbSNP
rs61543509 1935 dbSNP
rs1036035024 1939 dbSNP
rs1411624965 1944 dbSNP
rs1045369006 1954 dbSNP
rs1296982748 1960 dbSNP
rs920429934 1960 dbSNP
rs902878675 1969 dbSNP
rs138560610 1971 dbSNP
rs1366938032 1972 dbSNP
rs1050783472 1988 dbSNP
rs1404416581 1998 dbSNP
rs889069714 1999 dbSNP
rs1187475835 2004 dbSNP
rs559905900 2013 dbSNP
rs1054624768 2016 dbSNP
rs528571786 2023 dbSNP
rs1447562637 2027 dbSNP
rs1294106111 2030 dbSNP
rs1282572104 2034 dbSNP
rs1321385900 2037 dbSNP
rs892465238 2041 dbSNP
rs1216125562 2043 dbSNP
rs529725080 2049 dbSNP
rs1338226891 2054 dbSNP
rs565125099 2058 dbSNP
rs115569816 2067 dbSNP
rs1022351414 2077 dbSNP
rs1340623968 2086 dbSNP
rs1207986061 2094 dbSNP
rs550994038 2095 dbSNP
rs1441407318 2098 dbSNP
rs1065490 2102 dbSNP
rs1065491 2104 dbSNP
rs753988072 2104 dbSNP
rs1238789046 2105 dbSNP
rs1472936606 2109 dbSNP
rs1167694312 2110 dbSNP
rs1065492 2117 dbSNP
rs1388141137 2119 dbSNP
rs891047173 2120 dbSNP
rs1233656467 2122 dbSNP
rs1206936626 2123 dbSNP
rs1431535232 2127 dbSNP
rs75635698 2139 dbSNP
rs1315808821 2147 dbSNP
rs570710221 2151 dbSNP
rs1401412529 2159 dbSNP
rs1223994938 2175 dbSNP
rs1325592651 2183 dbSNP
rs1298484271 2190 dbSNP
rs183120513 2196 dbSNP
rs1373513736 2198 dbSNP
rs1002345222 2199 dbSNP
rs10138459 2206 dbSNP
rs530252860 2209 dbSNP
rs546769705 2210 dbSNP
rs1379899853 2229 dbSNP
rs368281635 2230 dbSNP
rs992811359 2239 dbSNP
rs1297297330 2241 dbSNP
rs1408865161 2241 dbSNP
rs1456632688 2242 dbSNP
rs1023980420 2249 dbSNP
rs1231251092 2272 dbSNP
rs12879179 2277 dbSNP
rs1027487341 2283 dbSNP
rs1462532567 2286 dbSNP
rs1254169862 2291 dbSNP
rs188140356 2299 dbSNP
rs1252335455 2305 dbSNP
rs538338790 2310 dbSNP
rs1316965394 2320 dbSNP
rs959533708 2320 dbSNP
rs991387527 2325 dbSNP
rs755551627 2335 dbSNP
rs1308544220 2338 dbSNP
rs918124339 2341 dbSNP
rs971804172 2350 dbSNP
rs1331036621 2356 dbSNP
rs558179075 2364 dbSNP
rs1453822846 2367 dbSNP
rs1442616207 2368 dbSNP
rs920313804 2370 dbSNP
rs568765354 2376 dbSNP
rs924249694 2389 dbSNP
rs934336703 2398 dbSNP
rs539651557 2410 dbSNP
rs1160534744 2412 dbSNP
rs1437999775 2414 dbSNP
rs3207455 2428 dbSNP
rs1054169482 2429 dbSNP
rs1379903496 2430 dbSNP
rs1245955451 2456 dbSNP
rs892872285 2458 dbSNP
rs537810988 2464 dbSNP
rs1188988142 2467 dbSNP
rs1049572670 2471 dbSNP
rs890994790 2477 dbSNP
rs1008120348 2479 dbSNP
rs772442081 2480 dbSNP
rs191230837 2483 dbSNP
rs1287458636 2490 dbSNP
rs1213847004 2494 dbSNP
rs1170864036 2497 dbSNP
rs1404503836 2500 dbSNP
rs1015538889 2507 dbSNP
rs1470418703 2508 dbSNP
rs546738643 2509 dbSNP
rs1247772650 2532 dbSNP
rs944674839 2544 dbSNP
rs1320219940 2545 dbSNP
rs748756447 2548 dbSNP
rs1040663148 2552 dbSNP
rs574644939 2552 dbSNP
rs10141110 2554 dbSNP
rs1296773753 2557 dbSNP
rs945336583 2558 dbSNP
rs1417931227 2563 dbSNP
rs1231764590 2566 dbSNP
rs1164429409 2569 dbSNP
rs1459661112 2570 dbSNP
rs1366460663 2571 dbSNP
rs372451375 2575 dbSNP
rs553991552 2576 dbSNP
rs1186587553 2577 dbSNP
rs1428994292 2578 dbSNP
rs1265234780 2587 dbSNP
rs777286201 2598 dbSNP
rs1276090480 2604 dbSNP
rs1487660051 2612 dbSNP
rs749193050 2612 dbSNP
rs1291895396 2621 dbSNP
rs903961710 2622 dbSNP
rs770921413 2623 dbSNP
rs1263984551 2624 dbSNP
rs1244499988 2632 dbSNP
rs1002696610 2634 dbSNP
rs1280614058 2642 dbSNP
rs573415293 2644 dbSNP
rs1033885065 2645 dbSNP
rs149301797 2646 dbSNP
rs1205461008 2655 dbSNP
rs1025084406 2656 dbSNP
rs565333953 2658 dbSNP
rs970882057 2660 dbSNP
rs1431349185 2665 dbSNP
rs1015773270 2668 dbSNP
rs1200987443 2674 dbSNP
rs1162952056 2675 dbSNP
rs1379441092 2676 dbSNP
rs1462302374 2684 dbSNP
rs1480769336 2690 dbSNP
rs1425564017 2692 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084065. RNA binding protein: AGO2. Condition:CLIP_emetine_AbnovaAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' uaagCUACUGAGUCAGAGAAgaa 5'
              || ||:||  ||||||   
Target 5' gaggGAAGAUUC--UCUCUU--- 3'
 		5 - 22
Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM1084065
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_emetine_AbnovaAb
Location of target site ENST00000395718.2 | 3UTR | GAAAGAGGGAAGAUUCUCUCUU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
130 hsa-miR-5197-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT055372 PDCD4 programmed cell death 4 2 4
MIRT063381 ETNK1 ethanolamine kinase 1 2 2
MIRT068048 SAP18 Sin3A associated protein 18 2 6
MIRT070247 FRMD6 FERM domain containing 6 2 2
MIRT088320 RAB10 RAB10, member RAS oncogene family 2 4
MIRT097550 VCAN versican 2 2
MIRT130055 TRAF6 TNF receptor associated factor 6 2 2
MIRT164190 SCOC short coiled-coil protein 2 2
MIRT183552 BTG2 BTG anti-proliferation factor 2 2 4
MIRT194954 TNRC6A trinucleotide repeat containing 6A 2 2
MIRT199034 POLI DNA polymerase iota 2 2
MIRT200619 BCL3 B-cell CLL/lymphoma 3 2 2
MIRT231349 SERPINH1 serpin family H member 1 2 2
MIRT243305 SLC25A36 solute carrier family 25 member 36 2 2
MIRT270950 GPRC5A G protein-coupled receptor class C group 5 member A 2 2
MIRT295297 BTBD3 BTB domain containing 3 2 6
MIRT295775 MAPRE1 microtubule associated protein RP/EB family member 1 2 2
MIRT297115 GCC2 GRIP and coiled-coil domain containing 2 2 6
MIRT333632 ZFP91 ZFP91 zinc finger protein 2 2
MIRT338923 HMGN2 high mobility group nucleosomal binding domain 2 2 2
MIRT344878 WIPF2 WAS/WASL interacting protein family member 2 2 2
MIRT352038 BZW1 basic leucine zipper and W2 domains 1 2 4
MIRT360289 HIST1H3E histone cluster 1 H3 family member e 2 2
MIRT362931 CLDN12 claudin 12 2 2
MIRT375251 MAPK8IP3 mitogen-activated protein kinase 8 interacting protein 3 2 4
MIRT405442 RAB5B RAB5B, member RAS oncogene family 2 2
MIRT442511 OSBP oxysterol binding protein 2 2
MIRT443281 TSPAN15 tetraspanin 15 2 2
MIRT443379 PLXNA2 plexin A2 2 2
MIRT443900 NUTM2E NUT family member 2E 2 2
MIRT445537 MOG myelin oligodendrocyte glycoprotein 2 2
MIRT446235 C17orf80 chromosome 17 open reading frame 80 2 2
MIRT446962 ZNF431 zinc finger protein 431 2 2
MIRT447545 RNF165 ring finger protein 165 2 2
MIRT447686 MTPAP mitochondrial poly(A) polymerase 2 2
MIRT450499 LIMD2 LIM domain containing 2 2 2
MIRT451257 ZNF444 zinc finger protein 444 2 2
MIRT453934 COMMD5 COMM domain containing 5 2 4
MIRT454042 DDT D-dopachrome tautomerase 2 2
MIRT454549 RABL2A RAB, member of RAS oncogene family like 2A 2 2
MIRT456455 TMEM81 transmembrane protein 81 2 2
MIRT456546 TMEM63A transmembrane protein 63A 2 2
MIRT456614 SFMBT2 Scm like with four mbt domains 2 2 2
MIRT456634 ARMCX6 armadillo repeat containing, X-linked 6 2 2
MIRT457258 RABL2B RAB, member of RAS oncogene family like 2B 2 2
MIRT458092 C8orf33 chromosome 8 open reading frame 33 2 2
MIRT458210 FOXL2 forkhead box L2 2 2
MIRT458459 RPRM reprimo, TP53 dependent G2 arrest mediator homolog 2 2
MIRT458700 LEPREL1 prolyl 3-hydroxylase 2 1 1
MIRT461649 ZSWIM4 zinc finger SWIM-type containing 4 2 2
MIRT461996 PACSIN1 protein kinase C and casein kinase substrate in neurons 1 2 2
MIRT462237 PRSS16 protease, serine 16 2 2
MIRT464774 UBE2G1 ubiquitin conjugating enzyme E2 G1 2 2
MIRT465051 TTC14 tetratricopeptide repeat domain 14 2 2
MIRT465393 TPD52L2 tumor protein D52 like 2 2 2
MIRT467612 SLC7A5 solute carrier family 7 member 5 2 2
MIRT467938 SLC16A6 solute carrier family 16 member 6 2 2
MIRT470022 PTP4A2 protein tyrosine phosphatase type IVA, member 2 2 2
MIRT470049 PTGFRN prostaglandin F2 receptor inhibitor 2 2
MIRT470514 PPP1R11 protein phosphatase 1 regulatory inhibitor subunit 11 2 2
MIRT471073 PIM2 Pim-2 proto-oncogene, serine/threonine kinase 2 2
MIRT471610 PAQR5 progestin and adipoQ receptor family member 5 2 18
MIRT472026 NPM1 nucleophosmin 1 2 2
MIRT474358 KMT2D lysine methyltransferase 2D 2 2
MIRT474681 KLF10 Kruppel like factor 10 2 2
MIRT474878 KDELR1 KDEL endoplasmic reticulum protein retention receptor 1 2 2
MIRT477137 FAM107B family with sequence similarity 107 member B 2 6
MIRT477850 DYRK3 dual specificity tyrosine phosphorylation regulated kinase 3 2 2
MIRT477922 DUSP2 dual specificity phosphatase 2 2 2
MIRT479772 CCND1 cyclin D1 2 2
MIRT480108 CALR calreticulin 2 2
MIRT482161 AK2 adenylate kinase 2 2 2
MIRT482232 AHCYL2 adenosylhomocysteinase like 2 2 2
MIRT483455 ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor 6 2 4
MIRT487256 KHSRP KH-type splicing regulatory protein 2 2
MIRT488677 SPAM1 sperm adhesion molecule 1 2 2
MIRT488930 GFRAL GDNF family receptor alpha like 2 2
MIRT489980 DDB1 damage specific DNA binding protein 1 2 2
MIRT492360 SEMA7A semaphorin 7A (John Milton Hagen blood group) 2 2
MIRT493688 HAP1 huntingtin associated protein 1 2 2
MIRT497165 BBX BBX, HMG-box containing 2 2
MIRT498884 ZNF12 zinc finger protein 12 2 10
MIRT500182 CHRM3 cholinergic receptor muscarinic 3 2 2
MIRT501904 MED13 mediator complex subunit 13 2 2
MIRT505903 RIMS3 regulating synaptic membrane exocytosis 3 2 6
MIRT506597 MECP2 methyl-CpG binding protein 2 2 4
MIRT508945 AK4 adenylate kinase 4 2 4
MIRT510650 TMEM167A transmembrane protein 167A 2 4
MIRT512847 A1CF APOBEC1 complementation factor 2 6
MIRT514490 SLPI secretory leukocyte peptidase inhibitor 2 4
MIRT520637 NPM3 nucleophosmin/nucleoplasmin 3 2 6
MIRT528919 TOMM20 translocase of outer mitochondrial membrane 20 2 6
MIRT529866 DGAT1 diacylglycerol O-acyltransferase 1 2 2
MIRT533359 UBE2W ubiquitin conjugating enzyme E2 W 2 2
MIRT534688 RNF125 ring finger protein 125 2 2
MIRT535930 MIER1 MIER1 transcriptional regulator 2 2
MIRT538253 CUL3 cullin 3 2 4
MIRT546021 WDR26 WD repeat domain 26 2 4
MIRT547354 NAT8L N-acetyltransferase 8 like 2 2
MIRT549430 ACVR1 activin A receptor type 1 2 2
MIRT551488 TMEM192 transmembrane protein 192 2 4
MIRT554624 RPS6KA3 ribosomal protein S6 kinase A3 2 2
MIRT560155 MOB1A MOB kinase activator 1A 2 2
MIRT560447 ALG14 ALG14, UDP-N-acetylglucosaminyltransferase subunit 2 2
MIRT560711 ZNF324B zinc finger protein 324B 2 2
MIRT560962 WRN Werner syndrome RecQ like helicase 2 2
MIRT563870 FAM206A family with sequence similarity 206 member A 2 2
MIRT564138 ZNF689 zinc finger protein 689 2 2
MIRT568121 CDC27 cell division cycle 27 2 2
MIRT568141 CCDC88C coiled-coil domain containing 88C 2 2
MIRT568285 BCOR BCL6 corepressor 2 2
MIRT568469 ARMC12 armadillo repeat containing 12 2 2
MIRT569742 GPR173 G protein-coupled receptor 173 2 2
MIRT570175 LIPG lipase G, endothelial type 2 2
MIRT570545 RPH3A rabphilin 3A 2 2
MIRT570952 CPE carboxypeptidase E 2 2
MIRT572800 SIGLEC14 sialic acid binding Ig like lectin 14 2 2
MIRT573114 ERBB2IP erbb2 interacting protein 2 2
MIRT574212 SDCBP syndecan binding protein 2 2
MIRT574662 KIF5B kinesin family member 5B 2 2
MIRT662448 SERPINB5 serpin family B member 5 2 2
MIRT695768 C4orf33 chromosome 4 open reading frame 33 2 2
MIRT705832 AIFM2 apoptosis inducing factor, mitochondria associated 2 2 2
MIRT712185 SRSF10 serine and arginine rich splicing factor 10 2 2
MIRT712996 CDV3 CDV3 homolog 2 2
MIRT714411 ZNF706 zinc finger protein 706 2 2
MIRT719226 CAMK4 calcium/calmodulin dependent protein kinase IV 2 2
MIRT720279 EIF1AD eukaryotic translation initiation factor 1A domain containing 2 2
MIRT720946 PPP1R3E protein phosphatase 1 regulatory subunit 3E 2 2
MIRT723201 KLHDC10 kelch domain containing 10 2 2

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