miRTarBase - #MIRT070774


—
pre-miRNA Information
pre-miRNA hsa-mir-4282   
Genomic Coordinates chr6: 72967687 - 72967753
Description Homo sapiens miR-4282 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4282
Sequence 40| UAAAAUUUGCAUCCAGGA |57
Evidence Experimental
Experiments SOLiD
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSN32074657 13 COSMIC
COSN6331413 18 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1195771339 5 dbSNP
rs755058572 6 dbSNP
rs1245753664 11 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol HIF1A   
Synonyms HIF-1-alpha, HIF-1A, HIF-1alpha, HIF1, HIF1-ALPHA, MOP1, PASD8, bHLHe78
Description hypoxia inducible factor 1 alpha subunit
Transcript NM_181054   
Other Transcripts NM_001530   
Expression
Putative miRNA Targets on HIF1A
3'UTR of HIF1A
(miRNA target sites are highlighted)		 
>HIF1A|NM_181054|3'UTR
   1 CATGTAGACTGCTGGGGCAATCAATGGATGAAAGTGGATTACCACAGCTGACCAGTTATGATTGTGAAGTTAATGCTCCT
  81 ATACAAGGCAGCAGAAACCTACTGCAGGGTGAAGAATTACTCAGAGCTTTGGATCAAGTTAACTGAGCTTTTTCTTAATT
 161 TCATTCCTTTTTTTGGACACTGGTGGCTCATTACCTAAAGCAGTCTATTTATATTTTCTACATCTAATTTTAGAAGCCTG
 241 GCTACAATACTGCACAAACTTGGTTAGTTCAATTTTGATCCCCTTTCTACTTAATTTACATTAATGCTCTTTTTTAGTAT
 321 GTTCTTTAATGCTGGATCACAGACAGCTCATTTTCTCAGTTTTTTGGTATTTAAACCATTGCATTGCAGTAGCATCATTT
 401 TAAAAAATGCACCTTTTTATTTATTTATTTTTGGCTAGGGAGTTTATCCCTTTTTCGAATTATTTTTAAGAAGATGCCAA
 481 TATAATTTTTGTAAGAAGGCAGTAACCTTTCATCATGATCATAGGCAGTTGAAAAATTTTTACACCTTTTTTTTCACATT
 561 TTACATAAATAATAATGCTTTGCCAGCAGTACGTGGTAGCCACAATTGCACAATATATTTTCTTAAAAAATACCAGCAGT
 641 TACTCATGGAATATATTCTGCGTTTATAAAACTAGTTTTTAAGAAGAAATTTTTTTTGGCCTATGAAATTGTTAAACCTG
 721 GAACATGACATTGTTAATCATATAATAATGATTCTTAAATGCTGTATGGTTTATTATTTAAATGGGTAAAGCCATTTACA
 801 TAATATAGAAAGATATGCATATATCTAGAAGGTATGTGGCATTTATTTGGATAAAATTCTCAATTCAGAGAAATCATCTG
 881 ATGTTTCTATAGTCACTTTGCCAGCTCAAAAGAAAACAATACCCTATGTAGTTGTGGAAGTTTATGCTAATATTGTGTAA
 961 CTGATATTAAACCTAAATGTTCTGCCTACCCTGTTGGTATAAAGATATTTTGAGCAGACTGTAAACAAGAAAAAAAAAAT
1041 CATGCATTCTTAGCAAAATTGCCTAGTATGTTAATTTGCTCAAAATACAATGTTTGATTTTATGCACTTTGTCGCTATTA
1121 ACATCCTTTTTTTCATGTAGATTTCAATAATTGAGTAATTTTAGAAGCATTATTTTAGGAATATATAGTTGTCACAGTAA
1201 ATATCTTGTTTTTTCTATGTACATTGTACAAATTTTTCATTCCTTTTGCTCTTTGTGGTTGGATCTAACACTAACTGTAT
1281 TGTTTTGTTACATCAAATAAACATCTTCTGTGGACCAGGCAAAAAAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' agGACCUACGUUUAAAAu 5'
            :|||||  ||||| | 
Target 5' atTTGGAT-AAAATTCTc 3'
 845 - 861 123.00 -5.82
2 
miRNA  3' aggaccUACGUUUAAAau 5'
                |||:|:||||  
Target 5' tttttcATGTAGATTTca 3'
 1129 - 1146 120.00 -5.30
3 
miRNA  3' agGA-CCUACGUUUAAAau 5'
            || | |||: |||||  
Target 5' gcCTAGTATGTTAATTTgc 3'
 1061 - 1079 108.00 -5.80
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
709474 18 ClinVar
COSM8236443 25 COSMIC
COSM2247247 35 COSMIC
COSM956814 48 COSMIC
COSM2247248 50 COSMIC
COSM1159287 53 COSMIC
COSM9470578 72 COSMIC
COSM3386615 73 COSMIC
COSM7702681 79 COSMIC
COSM8720098 82 COSMIC
COSM1158010 89 COSMIC
COSM4577931 90 COSMIC
COSM6328155 92 COSMIC
COSM4636919 104 COSMIC
COSN31598380 154 COSMIC
COSN22510195 156 COSMIC
COSN30146484 163 COSMIC
COSN30479229 168 COSMIC
COSN5853537 175 COSMIC
COSN20389672 179 COSMIC
COSN31497155 184 COSMIC
COSN20087972 192 COSMIC
COSN30511452 209 COSMIC
COSN26307819 237 COSMIC
COSN30166240 249 COSMIC
COSN31513196 252 COSMIC
COSN21620339 254 COSMIC
COSN24313377 271 COSMIC
COSN20111388 277 COSMIC
COSN20066277 279 COSMIC
COSN30524741 305 COSMIC
COSN31535736 366 COSMIC
COSN26581982 390 COSMIC
COSN31595948 448 COSMIC
COSN31569975 458 COSMIC
COSN26586676 500 COSMIC
COSN31611055 608 COSMIC
COSN30541333 683 COSMIC
COSN18936091 787 COSMIC
COSN31585350 813 COSMIC
COSN23687473 821 COSMIC
COSN8846910 826 COSMIC
COSN31547288 871 COSMIC
COSN31606639 871 COSMIC
COSN9089004 881 COSMIC
COSN31484977 897 COSMIC
COSN29683013 1040 COSMIC
COSN21324998 1080 COSMIC
COSN1169739 1134 COSMIC
COSN31593408 1215 COSMIC
COSN31516638 1232 COSMIC
COSN31563647 1316 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs539549822 5 dbSNP
rs772563698 15 dbSNP
rs74054863 18 dbSNP
rs761301966 25 dbSNP
rs764342882 27 dbSNP
rs1434107649 30 dbSNP
rs777173441 32 dbSNP
rs148149561 45 dbSNP
rs762084100 46 dbSNP
rs1332732959 48 dbSNP
rs1400361157 51 dbSNP
rs1802821 52 dbSNP
rs765575235 56 dbSNP
rs545874061 60 dbSNP
rs762942023 63 dbSNP
rs758032673 64 dbSNP
rs1294810529 71 dbSNP
rs1315936022 72 dbSNP
rs1220369809 75 dbSNP
rs1354416944 79 dbSNP
rs1002016670 80 dbSNP
rs1258843938 82 dbSNP
rs1334246808 84 dbSNP
rs766542880 85 dbSNP
rs140173615 90 dbSNP
rs754986249 92 dbSNP
rs780928465 93 dbSNP
rs559651239 99 dbSNP
rs145319047 103 dbSNP
rs1325345716 105 dbSNP
rs1172010116 111 dbSNP
rs1295805684 112 dbSNP
rs1423792468 115 dbSNP
rs1434851318 120 dbSNP
rs1366526923 127 dbSNP
rs1404187796 128 dbSNP
rs1162266976 129 dbSNP
rs777407997 132 dbSNP
rs759636243 142 dbSNP
rs1389320297 145 dbSNP
rs770333662 146 dbSNP
rs371720529 148 dbSNP
rs1387964413 149 dbSNP
rs1338114141 152 dbSNP
rs778533208 153 dbSNP
rs747441284 156 dbSNP
rs1026312234 157 dbSNP
rs552985977 165 dbSNP
rs371778537 166 dbSNP
rs769316153 167 dbSNP
rs1292325060 168 dbSNP
rs779790779 168 dbSNP
rs780828413 168 dbSNP
rs1322499060 169 dbSNP
rs1215298795 173 dbSNP
rs1284371531 178 dbSNP
rs1489469817 181 dbSNP
rs777085247 182 dbSNP
rs762278418 186 dbSNP
rs1472198228 188 dbSNP
rs2057482 192 dbSNP
rs773559645 194 dbSNP
rs763289041 196 dbSNP
rs1210541354 200 dbSNP
rs542082268 202 dbSNP
rs750111993 208 dbSNP
rs964865492 222 dbSNP
rs978881402 231 dbSNP
rs1272811246 236 dbSNP
rs775751381 241 dbSNP
rs1343396726 242 dbSNP
rs561963703 247 dbSNP
rs1272414694 248 dbSNP
rs983334130 253 dbSNP
rs1033251976 254 dbSNP
rs769353565 258 dbSNP
rs1406298050 263 dbSNP
rs530984621 263 dbSNP
rs1203608510 264 dbSNP
rs549497743 268 dbSNP
rs1307099949 270 dbSNP
rs1249381070 271 dbSNP
rs199915104 273 dbSNP
rs397897404 273 dbSNP
rs5809121 273 dbSNP
rs913568799 283 dbSNP
rs563032969 292 dbSNP
rs1477633716 294 dbSNP
rs949034822 299 dbSNP
rs981877125 300 dbSNP
rs949635893 307 dbSNP
rs1199642529 325 dbSNP
rs1249880441 333 dbSNP
rs532181605 337 dbSNP
rs551891037 355 dbSNP
rs1483509684 356 dbSNP
rs982365060 360 dbSNP
rs926344697 373 dbSNP
rs1199119871 377 dbSNP
rs937859002 380 dbSNP
rs926624286 385 dbSNP
rs1224815816 389 dbSNP
rs1348150414 390 dbSNP
rs938038646 399 dbSNP
rs1200937897 402 dbSNP
rs1037532137 403 dbSNP
rs1331894483 404 dbSNP
rs1413747297 419 dbSNP
rs1053786420 437 dbSNP
rs1170221751 456 dbSNP
rs893855163 457 dbSNP
rs763243537 458 dbSNP
rs1432176686 460 dbSNP
rs1309109880 463 dbSNP
rs1041908240 464 dbSNP
rs1473015674 478 dbSNP
rs1365494899 481 dbSNP
rs565632163 483 dbSNP
rs1403254921 486 dbSNP
rs151303260 487 dbSNP
rs1442274612 490 dbSNP
rs1297315230 492 dbSNP
rs1279938106 502 dbSNP
rs1008558586 508 dbSNP
rs17099190 518 dbSNP
rs1019564762 521 dbSNP
rs1266893123 522 dbSNP
rs140525186 530 dbSNP
rs1293213243 547 dbSNP
rs996483325 547 dbSNP
rs1026672127 555 dbSNP
rs1308966626 556 dbSNP
rs1048073800 558 dbSNP
rs1291015828 559 dbSNP
rs952532711 564 dbSNP
rs890474693 593 dbSNP
rs1401402955 594 dbSNP
rs1410435090 597 dbSNP
rs1161740541 598 dbSNP
rs1472599652 599 dbSNP
rs1246737090 602 dbSNP
rs1185844172 608 dbSNP
rs982562264 613 dbSNP
rs1248001518 615 dbSNP
rs1485359835 632 dbSNP
rs186070865 634 dbSNP
rs1184337665 636 dbSNP
rs1008828153 640 dbSNP
rs1016170938 640 dbSNP
rs970960593 648 dbSNP
rs1017666271 649 dbSNP
rs900581021 662 dbSNP
rs1356614289 663 dbSNP
rs982312779 665 dbSNP
rs1432702227 675 dbSNP
rs1417832408 681 dbSNP
rs1321218907 682 dbSNP
rs112980101 690 dbSNP
rs1431556853 704 dbSNP
rs537228141 710 dbSNP
rs1346981030 713 dbSNP
rs1000351887 718 dbSNP
rs926907138 723 dbSNP
rs751806225 725 dbSNP
rs1165838369 735 dbSNP
rs1448086868 741 dbSNP
rs1305448254 742 dbSNP
rs1390096297 743 dbSNP
rs1451785185 746 dbSNP
rs1169620714 749 dbSNP
rs1385201243 757 dbSNP
rs1033135776 762 dbSNP
rs1225899795 769 dbSNP
rs1293545948 769 dbSNP
rs1423265139 771 dbSNP
rs34873475 778 dbSNP
rs1341271847 783 dbSNP
rs1325634233 787 dbSNP
rs956362576 792 dbSNP
rs8019084 794 dbSNP
rs762252347 801 dbSNP
rs945443994 815 dbSNP
rs1042515017 817 dbSNP
rs1287270892 822 dbSNP
rs767862625 837 dbSNP
rs1428202134 847 dbSNP
rs1370274736 867 dbSNP
rs1228951010 872 dbSNP
rs1314065298 879 dbSNP
rs1357227551 887 dbSNP
rs981762514 890 dbSNP
rs1430768103 891 dbSNP
rs1248034618 893 dbSNP
rs926396778 900 dbSNP
rs1040910292 902 dbSNP
rs879291501 913 dbSNP
rs996771147 922 dbSNP
rs973110354 926 dbSNP
rs952877554 928 dbSNP
rs920448595 933 dbSNP
rs929103345 935 dbSNP
rs1310343873 936 dbSNP
rs1048503409 937 dbSNP
rs1047656959 953 dbSNP
rs888154356 954 dbSNP
rs1346293284 962 dbSNP
rs190860864 967 dbSNP
rs1408156600 985 dbSNP
rs1350131716 994 dbSNP
rs1299083231 995 dbSNP
rs1242865466 996 dbSNP
rs944737744 1000 dbSNP
rs1463890765 1001 dbSNP
rs539881963 1005 dbSNP
rs773972883 1016 dbSNP
rs1357928211 1020 dbSNP
rs1443359225 1027 dbSNP
rs1176055068 1028 dbSNP
rs1470597308 1029 dbSNP
rs1015368010 1030 dbSNP
rs1430709945 1030 dbSNP
rs971292665 1030 dbSNP
rs1165437560 1040 dbSNP
rs1039002996 1041 dbSNP
rs1178692650 1042 dbSNP
rs1414641588 1054 dbSNP
rs750960087 1073 dbSNP
rs900632992 1082 dbSNP
rs534696980 1085 dbSNP
rs867054308 1090 dbSNP
rs180837209 1091 dbSNP
rs1033476211 1093 dbSNP
rs1308063073 1106 dbSNP
rs573160553 1111 dbSNP
rs891975089 1114 dbSNP
rs989725139 1115 dbSNP
rs1436031645 1119 dbSNP
rs915224690 1120 dbSNP
rs1408971422 1124 dbSNP
rs186481938 1126 dbSNP
rs978566180 1127 dbSNP
rs1010804073 1132 dbSNP
rs370476266 1133 dbSNP
rs1364013357 1134 dbSNP
rs1160909738 1137 dbSNP
rs1421701348 1142 dbSNP
rs114812759 1148 dbSNP
rs1024591004 1149 dbSNP
rs756658648 1152 dbSNP
rs972050428 1154 dbSNP
rs1003250403 1157 dbSNP
rs1380222271 1165 dbSNP
rs1450147761 1166 dbSNP
rs1033348128 1186 dbSNP
rs574800089 1193 dbSNP
rs1206902487 1198 dbSNP
rs958994442 1203 dbSNP
rs1350125414 1205 dbSNP
rs778376665 1208 dbSNP
rs1241371052 1209 dbSNP
rs911949361 1209 dbSNP
rs944788994 1209 dbSNP
rs920314952 1218 dbSNP
rs1314742202 1220 dbSNP
rs1385575406 1224 dbSNP
rs1433694893 1247 dbSNP
rs752265561 1252 dbSNP
rs983676896 1259 dbSNP
rs555623016 1262 dbSNP
rs921108454 1264 dbSNP
rs1446294210 1287 dbSNP
rs1269456542 1289 dbSNP
rs765677998 1292 dbSNP
rs1447522222 1300 dbSNP
rs1262471493 1302 dbSNP
rs1206996164 1309 dbSNP
rs561456816 1312 dbSNP
rs1487616499 1317 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Disease 3091.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM714644. RNA binding protein: AGO2. Condition:completeT1 "PAR-CLIP data was present in GSM714645. RNA binding protein: AGO2. Condition:completeT1 ...

- Kishore S; Jaskiewicz L; Burger L; Hausser et al., 2011, Nature methods.

Article - Kishore S; Jaskiewicz L; Burger L; Hausser et al.
- Nature methods, 2011
Cross-linking and immunoprecipitation (CLIP) is increasingly used to map transcriptome-wide binding sites of RNA-binding proteins. We developed a method for CLIP data analysis, and applied it to compare CLIP with photoactivatable ribonucleoside-enhanced CLIP (PAR-CLIP) and to uncover how differences in cross-linking and ribonuclease digestion affect the identified sites. We found only small differences in accuracies of these methods in identifying binding sites of HuR, which binds low-complexity sequences, and Argonaute 2, which has a complex binding specificity. We found that cross-link-induced mutations led to single-nucleotide resolution for both PAR-CLIP and CLIP. Our results confirm the expectation from original CLIP publications that RNA-binding proteins do not protect their binding sites sufficiently under the denaturing conditions used during the CLIP procedure, and we show that extensive digestion with sequence-specific RNases strongly biases the recovered binding sites. This bias can be substantially reduced by milder nuclease digestion conditions.
LinkOut: [PMID: 21572407]
CLIP-seq Support 1 for dataset GSM4903826
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / PID21_NS
Location of target site NM_181054 | 3UTR | UUUAAGAAGAAAUUUUU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161237
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM4903833
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_a
Location of target site NM_001530 | 3UTR | GAUAUUAAACCUAAAUGUUCUGCCUACCCUGUUGGUAUAAAGAUAUUUUGAGCAGACUGUAAACAAGAAAAAAAAAAUCAUGCAUUCUUAGCAAAAUUGCCUAGUAUGUUAAUUUGCUCAAAAUACAAUGUUUGAUUUUAUGCACUUUGUCGCUAUUAACAUCCUUUUUUUCAUGUAGAUUUCAAUAAUUGAGUAAUUUUAGAAGCAUUAUUUUAGGAAUAUAUAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM4903834
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_b
Location of target site NM_001530 | 3UTR | AUAAAGAUAUUUUGAGCAGACUGUAAACAAGAAAAAAAAAAUCAUGCAUUCUUAGCAAAAUUGCCUAGUAUGUUAAUUUGCUCAAAAUACAAUGUUUGAUUUUAUGCACUUUGUCGCUAUUAACAUCCUUUUUUUCAUGUAGAUUUCAAUAAUUGAGUAAUUUUAGAAGCAUUAUUUUAGGAAUAUAUAGUU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 4 for dataset GSM4903835
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_c
Location of target site NM_001530 | 3UTR | UUCUGCCUACCCUGUUGGUAUAAAGAUAUUUUGAGCAGACUGUAAACAAGAAAAAAAAAAUCAUGCAUUCUUAGCAAAAUUGCCUAGUAUGUUAAUUUGCUCAAAAUACAAUGUUUGAUUUUAUGCACUUUGUCGCUAUUAACAUCCUUUUUUUCAUGUAGAUUUCAAUAAUUGAGUAAUUUUAGAAGCAUUAUUUUAGGAAUAUAUAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 5 for dataset GSM4903836
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / 124_TD_21_a
Location of target site NM_001530 | 3UTR | AAUGUUCUGCCUACCCUGUUGGUAUAAAGAUAUUUUGAGCAGACUGUAAACAAGAAAAAAAAAAUCAUGCAUUCUUAGCAAAAUUGCCUAGUAUGUUAAUUUGCUCAAAAUACAAUGUUUGAUUUUAUGCACUUUGUCGCUAUUAACAUCCUUUUUUUCAUGUAGAUUUCAAUAAUUGAGUAAUUUUAGAAGCAUUAUUUUAGGAAUAUAUAGUU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 6 for dataset GSM4903837
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / 124_TD_21_b
Location of target site NM_001530 | 3UTR | GCAUUCUUAGCAAAAUUGCCUAGUAUGUUAAUUUGCUCAAAAUACAAUGUUUGAUUUUAUGCACUUUGUCGCUAUUAACAUCCUUUUUUUCAUGUAGAUUUCAAUAAUUGAGUAAUUUUAGAAGCAUUAUUUUAGGAAUAUAUAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 7 for dataset GSM4903838
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / 124_TD_21_c
Location of target site NM_001530 | 3UTR | UGUUCUGCCUACCCUGUUGGUAUAAAGAUAUUUUGAGCAGACUGUAAACAAGAAAAAAAAAAUCAUGCAUUCUUAGCAAAAUUGCCUAGUAUGUUAAUUUGCUCAAAAUACAAUGUUUGAUUUUAUGCACUUUGUCGCUAUUAACAUCCUUUUUUUCAUGUAGAUUUCAAUAAUUGAGUAAUUUUAGAAGCAUUAUUUUAGGAAUAUAUAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 8 for dataset GSM714644
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / completeT1, repA
Location of target site ENST00000323441.6 | 3UTR | UCUAUUUAUAUUUUCUACAUCUAAUUUUAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 21572407 / GSE28865
CLIP-seq Viewer Link
CLIP-seq Support 9 for dataset GSM714645
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / completeT1, repB
Location of target site ENST00000323441.6 | 3UTR | UCUAUUUAUAUUUUCUACAUCUAAUUUUAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 21572407 / GSE28865
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
280 hsa-miR-4282 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT057628 LCOR ligand dependent nuclear receptor corepressor 2 2
MIRT060732 RPS3 ribosomal protein S3 2 2
MIRT063371 ETNK1 ethanolamine kinase 1 2 2
MIRT066257 LRIG3 leucine rich repeats and immunoglobulin like domains 3 2 4
MIRT070774 HIF1A hypoxia inducible factor 1 alpha subunit 2 2
MIRT070871 EIF2S1 eukaryotic translation initiation factor 2 subunit alpha 2 4
MIRT078056 PCTP phosphatidylcholine transfer protein 2 2
MIRT078408 DCAF7 DDB1 and CUL4 associated factor 7 2 4
MIRT084059 PPP1R3D protein phosphatase 1 regulatory subunit 3D 2 2
MIRT093537 GALNT7 polypeptide N-acetylgalactosaminyltransferase 7 2 6
MIRT096072 SFXN1 sideroflexin 1 2 2
MIRT098316 REV3L REV3 like, DNA directed polymerase zeta catalytic subunit 2 2
MIRT100493 UHRF1BP1 UHRF1 binding protein 1 2 2
MIRT102254 HBP1 HMG-box transcription factor 1 2 4
MIRT105318 VPS37A VPS37A, ESCRT-I subunit 2 2
MIRT114143 MZT1 mitotic spindle organizing protein 1 2 4
MIRT114873 DICER1 dicer 1, ribonuclease III 2 2
MIRT134683 PNRC2 proline rich nuclear receptor coactivator 2 2 2
MIRT137640 RCOR1 REST corepressor 1 2 2
MIRT155449 CCNT2 cyclin T2 2 4
MIRT165656 DCTN4 dynactin subunit 4 2 2
MIRT177570 CSTF2T cleavage stimulation factor subunit 2 tau variant 2 4
MIRT188514 E2F7 E2F transcription factor 7 2 10
MIRT193019 TMOD3 tropomodulin 3 2 4
MIRT195823 GADD45A growth arrest and DNA damage inducible alpha 2 2
MIRT195885 DEPDC1 DEP domain containing 1 2 6
MIRT206029 NUP50 nucleoporin 50 2 6
MIRT212148 CLCN3 chloride voltage-gated channel 3 2 2
MIRT213999 DCP2 decapping mRNA 2 2 2
MIRT214650 HNRNPA0 heterogeneous nuclear ribonucleoprotein A0 2 2
MIRT221568 CBX3 chromobox 3 2 2
MIRT224544 ZNF623 zinc finger protein 623 2 2
MIRT227654 SET SET nuclear proto-oncogene 2 2
MIRT229992 CHIC1 cysteine rich hydrophobic domain 1 2 2
MIRT238968 QKI QKI, KH domain containing RNA binding 2 2
MIRT239825 ACTB actin beta 2 2
MIRT241084 ZXDA zinc finger, X-linked, duplicated A 2 4
MIRT244852 ZBTB5 zinc finger and BTB domain containing 5 2 2
MIRT264534 TARDBP TAR DNA binding protein 2 2
MIRT271438 SKI SKI proto-oncogene 2 2
MIRT271597 ENAH ENAH, actin regulator 2 2
MIRT294332 ZNF264 zinc finger protein 264 2 2
MIRT296341 PARD6B par-6 family cell polarity regulator beta 2 2
MIRT301715 TEF TEF, PAR bZIP transcription factor 2 2
MIRT308549 ZNF654 zinc finger protein 654 2 2
MIRT313866 DEPDC1B DEP domain containing 1B 2 2
MIRT315529 MARCKS myristoylated alanine rich protein kinase C substrate 2 2
MIRT321066 RABGEF1 RAB guanine nucleotide exchange factor 1 2 2
MIRT343777 NUTF2 nuclear transport factor 2 2 2
MIRT359109 MAP1B microtubule associated protein 1B 2 2
MIRT397393 GOLGA3 golgin A3 2 4
MIRT400822 CPEB2 cytoplasmic polyadenylation element binding protein 2 2 2
MIRT442171 DSEL dermatan sulfate epimerase-like 2 2
MIRT442777 JAG1 jagged 1 2 2
MIRT442862 SCARF1 scavenger receptor class F member 1 2 4
MIRT442919 PCBD2 pterin-4 alpha-carbinolamine dehydratase 2 2 2
MIRT444567 TRA2B transformer 2 beta homolog 2 2
MIRT444718 CMSS1 cms1 ribosomal small subunit homolog (yeast) 2 2
MIRT445018 RBMS3 RNA binding motif single stranded interacting protein 3 2 2
MIRT445853 LRRC1 leucine rich repeat containing 1 2 2
MIRT446242 HELZ helicase with zinc finger 2 2
MIRT446542 GOLGA8B golgin A8 family member B 2 2
MIRT446643 SPTY2D1 SPT2 chromatin protein domain containing 1 2 2
MIRT446948 ZMAT3 zinc finger matrin-type 3 2 4
MIRT447061 KCNAB1 potassium voltage-gated channel subfamily A member regulatory beta subunit 1 2 2
MIRT447327 ZSCAN21 zinc finger and SCAN domain containing 21 2 2
MIRT447995 CDX1 caudal type homeobox 1 2 2
MIRT448543 RHEBP1 RHEB pseudogene 1 2 6
MIRT448752 HINT1 histidine triad nucleotide binding protein 1 2 2
MIRT448772 GOLGA8A golgin A8 family member A 2 2
MIRT449342 WDR26 WD repeat domain 26 2 2
MIRT450011 SLC16A6 solute carrier family 16 member 6 2 4
MIRT450229 PCNX pecanex homolog 1 2 2
MIRT450340 MRPL17 mitochondrial ribosomal protein L17 2 4
MIRT450381 MSI2 musashi RNA binding protein 2 2 2
MIRT450759 PGGT1B protein geranylgeranyltransferase type I subunit beta 2 2
MIRT450809 NRCAM neuronal cell adhesion molecule 2 2
MIRT450947 ATAD2 ATPase family, AAA domain containing 2 2 2
MIRT459095 CCPG1 cell cycle progression 1 2 2
MIRT462428 TWISTNB TWIST neighbor 2 2
MIRT465200 TROVE2 TROVE domain family member 2 2 4
MIRT467382 SON SON DNA binding protein 2 4
MIRT468546 SERP1 stress associated endoplasmic reticulum protein 1 2 2
MIRT471506 PDE4D phosphodiesterase 4D 2 2
MIRT471981 NR3C1 nuclear receptor subfamily 3 group C member 1 2 2
MIRT474478 KLHL11 kelch like family member 11 2 8
MIRT475011 KANSL1 KAT8 regulatory NSL complex subunit 1 2 8
MIRT480341 C5orf51 chromosome 5 open reading frame 51 2 2
MIRT482696 TEX9 testis expressed 9 2 6
MIRT483462 YTHDF1 YTH N6-methyladenosine RNA binding protein 1 2 6
MIRT485623 FAM217B family with sequence similarity 217 member B 2 2
MIRT485714 CASP16 caspase 16, pseudogene 2 8
MIRT486279 SEC23A Sec23 homolog A, coat complex II component 2 2
MIRT491000 PEBP1 phosphatidylethanolamine binding protein 1 2 4
MIRT492594 PPIL4 peptidylprolyl isomerase like 4 2 2
MIRT493365 KIF5B kinesin family member 5B 2 2
MIRT494316 CDKN1B cyclin dependent kinase inhibitor 1B 2 2
MIRT495208 EDN3 endothelin 3 2 2
MIRT497011 TCF15 transcription factor 15 2 2
MIRT498512 FRK fyn related Src family tyrosine kinase 2 2
MIRT498778 PARP15 poly(ADP-ribose) polymerase family member 15 2 2
MIRT501045 SMG1 SMG1, nonsense mediated mRNA decay associated PI3K related kinase 2 6
MIRT502939 CDC37L1 cell division cycle 37 like 1 2 8
MIRT504806 VHL von Hippel-Lindau tumor suppressor 2 6
MIRT505656 SHMT1 serine hydroxymethyltransferase 1 2 6
MIRT505964 RAB5C RAB5C, member RAS oncogene family 2 6
MIRT506322 OTUD4 OTU deubiquitinase 4 2 4
MIRT506803 KLHL15 kelch like family member 15 2 6
MIRT506917 KBTBD8 kelch repeat and BTB domain containing 8 2 4
MIRT507400 EMC7 ER membrane protein complex subunit 7 2 8
MIRT507471 EDEM3 ER degradation enhancing alpha-mannosidase like protein 3 2 6
MIRT508058 ATP13A3 ATPase 13A3 2 4
MIRT508135 AMD1 adenosylmethionine decarboxylase 1 2 2
MIRT509895 RPS23 ribosomal protein S23 2 4
MIRT510881 RAN RAN, member RAS oncogene family 2 8
MIRT513766 PEX5L peroxisomal biogenesis factor 5 like 2 4
MIRT516898 COPS8 COP9 signalosome subunit 8 2 2
MIRT518703 TIMD4 T-cell immunoglobulin and mucin domain containing 4 2 4
MIRT520429 TTPAL alpha tocopherol transfer protein like 2 6
MIRT521843 PNISR PNN interacting serine and arginine rich protein 2 4
MIRT522116 NUDT3 nudix hydrolase 3 2 4
MIRT525467 TMPRSS12 transmembrane protease, serine 12 2 2
MIRT525583 MTRNR2L7 MT-RNR2-like 7 2 2
MIRT525906 BUB1 BUB1 mitotic checkpoint serine/threonine kinase 2 2
MIRT526072 C11orf54 chromosome 11 open reading frame 54 2 2
MIRT526232 MTRNR2L5 MT-RNR2-like 5 2 4
MIRT526455 FAM71F2 family with sequence similarity 71 member F2 2 4
MIRT526515 POU5F1B POU class 5 homeobox 1B 2 2
MIRT528032 FEZ2 fasciculation and elongation protein zeta 2 2 2
MIRT528422 MRPS16 mitochondrial ribosomal protein S16 2 2
MIRT528995 ISLR2 immunoglobulin superfamily containing leucine rich repeat 2 2 4
MIRT529311 ATRNL1 attractin like 1 2 2
MIRT529376 SKP1 S-phase kinase associated protein 1 2 4
MIRT530015 SRRM1 serine and arginine repetitive matrix 1 2 2
MIRT530089 FMN2 formin 2 2 2
MIRT530942 ENPP6 ectonucleotide pyrophosphatase/phosphodiesterase 6 2 2
MIRT531229 HIST1H2BD histone cluster 1 H2B family member d 2 2
MIRT533088 YTHDF3 YTH N6-methyladenosine RNA binding protein 3 2 2
MIRT533299 USP46 ubiquitin specific peptidase 46 2 2
MIRT533318 UNKL unkempt family like zinc finger 2 2
MIRT533721 TMEM30A transmembrane protein 30A 2 2
MIRT534096 AZF1 azoospermia factor 1 2 2
MIRT534188 SLC7A11 solute carrier family 7 member 11 2 2
MIRT534493 SAR1B secretion associated Ras related GTPase 1B 2 2
MIRT536077 MBOAT2 membrane bound O-acyltransferase domain containing 2 2 2
MIRT536242 LRIG2 leucine rich repeats and immunoglobulin like domains 2 2 2
MIRT537524 FAM104A family with sequence similarity 104 member A 2 2
MIRT538088 DGKH diacylglycerol kinase eta 2 2
MIRT538475 CNBP CCHC-type zinc finger nucleic acid binding protein 2 2
MIRT538853 BTG1 BTG anti-proliferation factor 1 2 4
MIRT539075 GDNF glial cell derived neurotrophic factor 2 2
MIRT539480 ACVR2B activin A receptor type 2B 2 4
MIRT540210 ARHGAP18 Rho GTPase activating protein 18 2 2
MIRT541940 TSPAN2 tetraspanin 2 2 2
MIRT543812 COCH cochlin 2 2
MIRT545120 PDZRN4 PDZ domain containing ring finger 4 2 2
MIRT545571 GIMAP4 GTPase, IMAP family member 4 2 2
MIRT545989 XKR4 XK related 4 2 2
MIRT547213 PANK3 pantothenate kinase 3 2 4
MIRT547740 KIAA1468 KIAA1468 2 2
MIRT548022 GRB2 growth factor receptor bound protein 2 2 4
MIRT548032 GOLIM4 golgi integral membrane protein 4 2 2
MIRT548102 GFPT1 glutamine--fructose-6-phosphate transaminase 1 2 4
MIRT548217 FKBP1A FK506 binding protein 1A 2 2
MIRT548588 DDX3X DEAD-box helicase 3, X-linked 2 4
MIRT548953 CDC27 cell division cycle 27 2 2
MIRT549072 CACUL1 CDK2 associated cullin domain 1 2 2
MIRT550368 INCENP inner centromere protein 2 6
MIRT550546 MYZAP myocardial zonula adherens protein 2 2
MIRT551491 TMEM192 transmembrane protein 192 2 4
MIRT553078 UEVLD UEV and lactate/malate dehyrogenase domains 2 2
MIRT554104 SMU1 DNA replication regulator and spliceosomal factor 2 2
MIRT555127 PTPRG protein tyrosine phosphatase, receptor type G 2 2
MIRT555477 POC1B-GALNT4 POC1B-GALNT4 readthrough 2 2
MIRT555978 NPTN neuroplastin 2 2
MIRT557011 HPRT1 hypoxanthine phosphoribosyltransferase 1 2 2
MIRT557706 GALNT4 polypeptide N-acetylgalactosaminyltransferase 4 2 2
MIRT558333 DNAJC28 DnaJ heat shock protein family (Hsp40) member C28 2 4
MIRT558488 DBN1 drebrin 1 2 2
MIRT559942 ZNF567 zinc finger protein 567 2 2
MIRT561127 ATP2B1 ATPase plasma membrane Ca2+ transporting 1 2 2
MIRT561791 PAWR pro-apoptotic WT1 regulator 2 2
MIRT562438 EEF2 eukaryotic translation elongation factor 2 2 2
MIRT563102 PABPC4L poly(A) binding protein cytoplasmic 4 like 2 2
MIRT563212 ZNF813 zinc finger protein 813 2 2
MIRT563426 KIF3A kinesin family member 3A 2 2
MIRT563473 SPIN4 spindlin family member 4 2 2
MIRT564015 HSPA4 heat shock protein family A (Hsp70) member 4 2 4
MIRT564117 ZYG11B zyg-11 family member B, cell cycle regulator 2 2
MIRT564223 SDE2 SDE2 telomere maintenance homolog 2 2
MIRT564503 CACNG1 calcium voltage-gated channel auxiliary subunit gamma 1 2 2
MIRT564515 DUSP3 dual specificity phosphatase 3 2 2
MIRT564811 ZBTB21 zinc finger and BTB domain containing 21 2 2
MIRT565265 TPD52 tumor protein D52 2 2
MIRT566012 RHOB ras homolog family member B 2 2
MIRT566216 PTMA prothymosin, alpha 2 2
MIRT566638 NFYA nuclear transcription factor Y subunit alpha 2 2
MIRT566821 MAPK8 mitogen-activated protein kinase 8 2 2
MIRT566948 LEPROT leptin receptor overlapping transcript 2 2
MIRT567290 HNRNPAB heterogeneous nuclear ribonucleoprotein A/B 2 2
MIRT567895 CSTF2 cleavage stimulation factor subunit 2 2 2
MIRT568731 MTRNR2L3 MT-RNR2-like 3 2 2
MIRT571263 ZNF239 zinc finger protein 239 2 2
MIRT572593 EIF2AK4 eukaryotic translation initiation factor 2 alpha kinase 4 2 2
MIRT573827 TGOLN2 trans-golgi network protein 2 2 2
MIRT576391 Fhl2 four and a half LIM domains 2 2 2
MIRT609901 SMS spermine synthase 2 2
MIRT613710 ELMSAN1 ELM2 and Myb/SANT domain containing 1 2 2
MIRT614406 ADAT1 adenosine deaminase, tRNA specific 1 2 2
MIRT615042 DCX doublecortin 2 2
MIRT617514 C5orf45 MRN complex interacting protein 2 2
MIRT619476 PRDM10 PR/SET domain 10 2 2
MIRT620349 TLN1 talin 1 2 2
MIRT620910 PLA2G7 phospholipase A2 group VII 2 2
MIRT622131 SP4 Sp4 transcription factor 2 2
MIRT622955 OTUD7B OTU deubiquitinase 7B 2 2
MIRT623351 MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3 2 2
MIRT623619 INTU inturned planar cell polarity protein 2 2
MIRT624409 CCDC171 coiled-coil domain containing 171 2 2
MIRT625171 CCS copper chaperone for superoxide dismutase 2 2
MIRT625685 RPP40 ribonuclease P/MRP subunit p40 2 2
MIRT625875 ALDH18A1 aldehyde dehydrogenase 18 family member A1 2 2
MIRT626002 FAM107A family with sequence similarity 107 member A 2 2
MIRT626872 HRH4 histamine receptor H4 2 4
MIRT628220 FKBP9 FK506 binding protein 9 2 2
MIRT628265 DIO2 iodothyronine deiodinase 2 2 2
MIRT628402 C8orf37 chromosome 8 open reading frame 37 2 2
MIRT630564 C3orf36 chromosome 3 open reading frame 36 2 4
MIRT631577 RASSF9 Ras association domain family member 9 2 2
MIRT635730 CCDC58 coiled-coil domain containing 58 2 2
MIRT636224 SLC8A1 solute carrier family 8 member A1 2 2
MIRT636613 CLIC5 chloride intracellular channel 5 2 2
MIRT638899 CDK9 cyclin dependent kinase 9 2 2
MIRT640167 ATXN7L1 ataxin 7 like 1 2 2
MIRT642070 GTDC1 glycosyltransferase like domain containing 1 2 2
MIRT643034 CHCHD7 coiled-coil-helix-coiled-coil-helix domain containing 7 2 2
MIRT644572 SPOP speckle type BTB/POZ protein 2 2
MIRT644954 IFNB1 interferon beta 1 2 2
MIRT645948 TTF2 transcription termination factor 2 2 2
MIRT646440 XRCC2 X-ray repair cross complementing 2 2 2
MIRT647896 EPN2 epsin 2 2 2
MIRT648276 ZNF582 zinc finger protein 582 2 2
MIRT649381 NEDD1 neural precursor cell expressed, developmentally down-regulated 1 2 2
MIRT650254 CD68 CD68 molecule 2 2
MIRT650333 ATP5S ATP synthase, H+ transporting, mitochondrial Fo complex subunit s (factor B) 2 2
MIRT651707 VMP1 vacuole membrane protein 1 2 2
MIRT651774 VASP vasodilator stimulated phosphoprotein 2 2
MIRT653144 SRPK2 SRSF protein kinase 2 2 2
MIRT654112 RPS6KA5 ribosomal protein S6 kinase A5 2 2
MIRT654161 RORB RAR related orphan receptor B 2 2
MIRT655716 MLF2 myeloid leukemia factor 2 2 2
MIRT657476 HDAC4 histone deacetylase 4 2 2
MIRT658095 FOXO1 forkhead box O1 2 2
MIRT658860 DTX3L deltex E3 ubiquitin ligase 3L 2 2
MIRT658988 DNAJA1 DnaJ heat shock protein family (Hsp40) member A1 2 2
MIRT660767 ALDH6A1 aldehyde dehydrogenase 6 family member A1 2 2
MIRT661622 C2orf15 chromosome 2 open reading frame 15 2 2
MIRT661694 TFDP2 transcription factor Dp-2 2 2
MIRT662208 PLA2G4E phospholipase A2 group IVE 2 2
MIRT662443 RALGAPA1 Ral GTPase activating protein catalytic alpha subunit 1 2 2
MIRT664422 ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide 2 2
MIRT687505 NECAB1 N-terminal EF-hand calcium binding protein 1 2 2
MIRT689910 SOD2 superoxide dismutase 2 2 2
MIRT690781 PLA2G2C phospholipase A2 group IIC 2 2
MIRT698488 TIAL1 TIA1 cytotoxic granule associated RNA binding protein like 1 2 2
MIRT699685 SFMBT2 Scm like with four mbt domains 2 2 2
MIRT700926 PDS5A PDS5 cohesin associated factor A 2 2
MIRT702258 LMNB1 lamin B1 2 2
MIRT703166 GPR137C G protein-coupled receptor 137C 2 2
MIRT703242 GNS glucosamine (N-acetyl)-6-sulfatase 2 2
MIRT704737 CENPQ centromere protein Q 2 2
MIRT707310 GLRX2 glutaredoxin 2 2 2
MIRT710021 KCNQ5 potassium voltage-gated channel subfamily Q member 5 2 2
MIRT712212 SCOC short coiled-coil protein 2 2
MIRT714742 SETBP1 SET binding protein 1 2 2
MIRT718268 ZNF749 zinc finger protein 749 2 2
MIRT720553 DYRK4 dual specificity tyrosine phosphorylation regulated kinase 4 2 2
MIRT722248 RBM41 RNA binding motif protein 41 2 2
MIRT723767 MPLKIP M-phase specific PLK1 interacting protein 2 2
MIRT723977 KIAA0146 scaffolding protein involved in DNA repair 1 1
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-4 Dexamethasone approved 5743 Microarray primary rat thymocytes 20847043 2010 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-4282 Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-4282 Neoadjuvant chemotherapy sensitive tissue (breast cancer)
hsa-miR-4282 Neoadjuvant chemotherapy sensitive tissue (breast cancer)

Error report submission