miRTarBase - #MIRT071004


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pre-miRNA Information
pre-miRNA hsa-mir-519c   
Genomic Coordinates chr19: 53686469 - 53686555
Description Homo sapiens miR-519c stem-loop
Comment The 5' arm of this precursor expresses a product related to miR-526 (previously named miR-526c here). Landgraf et al. confirm mature miRNA expression from both arms of the precursor .
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-519c-3p
Sequence 54| AAAGUGCAUCUUUUUAGAGGAU |75
Evidence Experimental
Experiments Array-cloned
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 2 19 + 53686523 29233923 MiREDiBase
A-to-I 3 19 + 53686524 29233923 MiREDiBase
A-to-I 8 19 + 53686529 29233923 MiREDiBase
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1164669230 4 dbSNP
rs764425172 8 dbSNP
rs1377433094 10 dbSNP
rs751997873 19 dbSNP
Putative Targets

miRNA Expression profile
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol SMOC1   
Synonyms OAS
Description SPARC related modular calcium binding 1
Transcript NM_001034852   
Other Transcripts NM_022137   
Expression
Putative miRNA Targets on SMOC1
3'UTR of SMOC1
(miRNA target sites are highlighted)		 
>SMOC1|NM_001034852|3'UTR
   1 GGAGCAGAAAACCCAAGGGCAGGTGGAGAGTCCAGGGAGGCAGGATGGATCACCAGACACCTAACCTTCAGCGTTGCCCA
  81 TGGCCCTGCCACATCCCGTGTAACATAAGTGGTGCCCACCATGTTTGCACTTTTAATAACTCTTACTTGCGTGTTTTGTT
 161 TTTGGTTTCATTTTAAAACACCAATATCTAATACCACAGTGGGAAAAGGAAAGGGAAGAAAGACTTTATTCTCTCTCTTA
 241 TTGTAAGTTTTTGGATCTGCTACTGACAACTTTTAGAGGGTTTTGGGGGGGTGGGGGAGGGTGTTGTTGGGGCTGAGAAG
 321 AAAGAGATTTATATGCTGTATATAAATATATATGTAAATTGTATAGTTCTTTTGTACAGGCATTGGCATTGCTGTTTGTT
 401 TATTTCTCTCCCTCTGCCTGCTGTGGGTGGTGGGCACTCTGGACACATAGTCCAGCTTTCTAAAATCCAGGACTCTATCC
 481 TGGGCCTACTAAACTTCTGTTTGGAGACTGACCCTTGTGTATAAAGACGGGAGTCCTGCAATTGTACTGCGGACTCCACG
 561 AGTTCTTTTCTGGTGGGAGGACTATATTGCCCCATGCCATTAGTTGTCAAAATTGATAAGTCACTTGGCTCTCGGCCTTG
 641 TCCAGGGAGGTTGGGCTAAGGAGAGATGGAAACTGCCCTGGGAGAGGAAGGGAGTCCAGATCCCATGAATAGCCCACACA
 721 GGTACCGGCTCTCAGAGGGTCCGTGCATTCCTGCTCTCCGGACCCCCAAAGGGCCCAGCATTGGTGGGTGCACCAGTATC
 801 TTAGTGACCCTCGGAGCAAATTATCCACAAAGGATTTGCATTACGTCACTCGAAACGTTTTCATCCATGCTTAGCATCTA
 881 CTCTGTATAACGCATGAGAGGGGAGGCAAAGAAGAAAAAGACACACAGAAGGGCCTTTAAAAAAGTAGATATTTAATATC
 961 TAAGCAGGGGAGGGGACAGGACAGAAAGCCTGCACTGAGGGGTGCGGTGCCAACAGGGAAACTCTTCACCTCCCTGCAAA
1041 CCTACCAGTGAGGCTCCCAGAGACGCAGCTGTCTCAGTGCCAGGGGCAGATTGGGTGTGACCTCTCCACTCCTCCATCTC
1121 CTGCTGTTGTCCTAGTGGCTATCACAGGCCTGGGTGGGTGGGTTGGGGGAGGTGTCAGTCACCTTGTTGGTAACACTAAA
1201 GTTGTTTTGTTGGTTTTTTAAAAACCCAATACTGAGGTTCTTCCTGTTCCCTCAAGTTTTCTTATGGGCTTCCAGGCTTT
1281 AAGCTAATTCCAGAAGTAAAACTGATCTTGGGTTTCCTATTCTGCCTCCCCTAGAAGGGCAGGGGTGATAACCCAGCTAC
1361 AGGGAAATCCCGGCCCAGCTTTCCACAGGCATCACAGGCATCTTCCGCGGATTCTAGGGTGGGCTGCCCAGCCTTCTGGT
1441 CTGAGGCGCAGCTCCCTCTGCCCAGGTGCTGTGCCTATTCAAGTGGCCTTCAGGCAGAGCAGCAAGTGGCCCTTAGCGCC
1521 CCTTCCCATAAGCAGCTGTGGTGGCAGTGAGGGAGGTTGGGTAGCCCTGGACTGGTCCCCTCCTCAGATCACCCTTGCAA
1601 ATCTGGCCTCATCTTGTATTCCAACCCGACATCCCTAAAAGTACCTCCACCCGTTCCGGGTCTGGAAGGCGTTGGCACCA
1681 CAAGCACTGTCCCTGTGGGAGGAGCACAACCTTCTCGGGACAGGATCTGATGGGGTCTTGGGCTAAAGGAGGTCCCTGCT
1761 GTCCTGGAGAAAGTCCTAGAGGTTATCTCAGGAATGACTGGTGGCCCTGCCCCAACGTGGAAAGGTGGGAAGGAAGCCTT
1841 CTCCCATTAGCCCCAATGAGAGAACTCAACGTGCCGGAGCTGAGTGGGCCTTGCACGAGACACTGGCCCCACTTTCAGGC
1921 CTGGAGGAAGCATGCACACATGGAGACGGCGCCTGCCTGTAGATGTTTGGATCTTCGAGATCTCCCCAGGCATCTTGTCT
2001 CCCACAGGATCGTGTGTGTAGGTGGTGTTGTGTGGTTTTCCTTTGTGAAGGAGAGAGGGAAACTATTTGTAGCTTGTTTT
2081 ATAAAAAATAAAAAATGGGTAAATCTTGAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' uaggagauuuuucuACGUGAAa 5'
                        ||||||| 
Target 5' gtgcccaccatgttTGCACTTt 3'
 112 - 133 140.00 -9.09
2 
miRNA  3' uaggagaUUUUUC-UACGUGAaa 5'
                 |:||||  ||||||  
Target 5' acaggacAGAAAGCCTGCACTga 3'
 976 - 998 135.00 -8.40
3 
miRNA  3' uaGGAGAUUUUUC-UACGUGaaa 5'
            |||  |::||| ||||||   
Target 5' ggCCTGGAGGAAGCATGCACaca 3'
 1918 - 1940 128.00 -15.32
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
1179798 81 ClinVar
COSM7894425 1 COSMIC
COSN31498861 14 COSMIC
COSN26995828 27 COSMIC
COSN30471586 38 COSMIC
COSN30474649 41 COSMIC
COSN30473617 44 COSMIC
COSN30180704 52 COSMIC
COSN30523177 55 COSMIC
COSN30109137 59 COSMIC
COSN30493640 73 COSMIC
COSN7025247 74 COSMIC
COSN30450005 80 COSMIC
COSN510799 81 COSMIC
COSN30758225 84 COSMIC
COSN31566862 86 COSMIC
COSN30186935 87 COSMIC
COSN30468626 97 COSMIC
COSN30455479 98 COSMIC
COSN30101405 107 COSMIC
COSN17132580 110 COSMIC
COSN30105495 157 COSMIC
COSN30162191 170 COSMIC
COSN31525873 185 COSMIC
COSN20085335 189 COSMIC
COSN8387149 238 COSMIC
COSN19507632 399 COSMIC
COSN31961000 529 COSMIC
COSN8156495 715 COSMIC
COSN20981518 827 COSMIC
COSN8848924 846 COSMIC
COSN5172170 899 COSMIC
COSN26774337 946 COSMIC
COSN6257547 1259 COSMIC
COSN23498266 1408 COSMIC
COSN8156496 1409 COSMIC
COSN15062860 1519 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs751567810 1 dbSNP
rs1354562365 2 dbSNP
rs1211820190 11 dbSNP
rs1291792043 13 dbSNP
rs1468707398 14 dbSNP
rs1301687926 15 dbSNP
rs760656651 15 dbSNP
rs1187858887 16 dbSNP
rs566181977 19 dbSNP
rs201525786 20 dbSNP
rs770017964 23 dbSNP
rs368841209 24 dbSNP
rs936350059 26 dbSNP
rs1456090383 27 dbSNP
rs749646389 28 dbSNP
rs769106450 29 dbSNP
rs774707485 39 dbSNP
rs373029308 43 dbSNP
rs949190906 45 dbSNP
rs770497921 49 dbSNP
rs1465301406 62 dbSNP
rs754560347 66 dbSNP
rs1464704561 69 dbSNP
rs184678642 73 dbSNP
rs370194954 74 dbSNP
rs7152085 81 dbSNP
rs886293554 84 dbSNP
rs1378933156 92 dbSNP
rs1027609797 96 dbSNP
rs1440913141 98 dbSNP
rs1004676638 99 dbSNP
rs1012758803 118 dbSNP
rs77498272 122 dbSNP
rs757925210 123 dbSNP
rs1212703307 124 dbSNP
rs1337857913 128 dbSNP
rs1220069311 135 dbSNP
rs898486266 138 dbSNP
rs1278366864 139 dbSNP
rs1240780568 141 dbSNP
rs1379073045 142 dbSNP
rs574982474 151 dbSNP
rs995508330 152 dbSNP
rs1028526199 163 dbSNP
rs536000675 169 dbSNP
rs1401713909 178 dbSNP
rs954260656 181 dbSNP
rs554318128 182 dbSNP
rs1008480736 185 dbSNP
rs924263028 186 dbSNP
rs1261107998 195 dbSNP
rs777615788 202 dbSNP
rs868049820 204 dbSNP
rs1489279193 210 dbSNP
rs189175828 214 dbSNP
rs966914838 219 dbSNP
rs1424675964 220 dbSNP
rs1422761827 223 dbSNP
rs575114117 230 dbSNP
rs978232692 232 dbSNP
rs1379192675 238 dbSNP
rs1487138539 238 dbSNP
rs1435251804 242 dbSNP
rs990137929 244 dbSNP
rs1032115560 248 dbSNP
rs957688660 250 dbSNP
rs776064218 257 dbSNP
rs1352692851 259 dbSNP
rs1263642792 268 dbSNP
rs1242608913 271 dbSNP
rs1234859645 278 dbSNP
rs546239570 282 dbSNP
rs1273546369 285 dbSNP
rs1349761805 285 dbSNP
rs1338771028 286 dbSNP
rs990518321 288 dbSNP
rs1298307921 290 dbSNP
rs1366445041 292 dbSNP
rs1050571121 293 dbSNP
rs1303859432 299 dbSNP
rs1313214673 300 dbSNP
rs912084919 302 dbSNP
rs944778604 305 dbSNP
rs916253961 307 dbSNP
rs897825877 308 dbSNP
rs1489574533 311 dbSNP
rs759053173 313 dbSNP
rs1265103537 316 dbSNP
rs1209149135 318 dbSNP
rs1357045622 321 dbSNP
rs1273859492 336 dbSNP
rs930662066 339 dbSNP
rs1277842360 340 dbSNP
rs1431849092 351 dbSNP
rs564499094 354 dbSNP
rs1328576430 357 dbSNP
rs1322055041 360 dbSNP
rs1246249440 362 dbSNP
rs1487609208 363 dbSNP
rs1392139900 374 dbSNP
rs949260887 380 dbSNP
rs1193207520 387 dbSNP
rs1269183202 392 dbSNP
rs1049413267 403 dbSNP
rs11540035 407 dbSNP
rs1013143002 420 dbSNP
rs1476220886 431 dbSNP
rs907688091 434 dbSNP
rs1197957997 441 dbSNP
rs1452089434 443 dbSNP
rs1254843084 444 dbSNP
rs1215598462 447 dbSNP
rs907066593 448 dbSNP
rs1257601037 450 dbSNP
rs770876370 451 dbSNP
rs1378356157 454 dbSNP
rs1037522592 458 dbSNP
rs898621535 466 dbSNP
rs1421496841 489 dbSNP
rs1159159294 496 dbSNP
rs931406422 499 dbSNP
rs1031465057 502 dbSNP
rs1398899743 508 dbSNP
rs1331515887 512 dbSNP
rs1411262648 512 dbSNP
rs1399682021 514 dbSNP
rs1433839089 517 dbSNP
rs1294864074 518 dbSNP
rs957221781 523 dbSNP
rs879530920 526 dbSNP
rs889800488 529 dbSNP
rs557738546 530 dbSNP
rs1019891775 532 dbSNP
rs1237636777 540 dbSNP
rs1205362510 542 dbSNP
rs989840628 543 dbSNP
rs902661508 545 dbSNP
rs1022945714 547 dbSNP
rs953637025 548 dbSNP
rs986374163 551 dbSNP
rs912053158 552 dbSNP
rs1376861381 553 dbSNP
rs1356438375 556 dbSNP
rs944912860 560 dbSNP
rs45447998 561 dbSNP
rs1032085419 563 dbSNP
rs1333106769 571 dbSNP
rs111757119 572 dbSNP
rs1377035881 575 dbSNP
rs547940516 581 dbSNP
rs1156686810 582 dbSNP
rs930609095 591 dbSNP
rs372675264 592 dbSNP
rs1177810347 598 dbSNP
rs559830945 600 dbSNP
rs1471202107 601 dbSNP
rs990588537 602 dbSNP
rs1049080582 617 dbSNP
rs1187085367 618 dbSNP
rs1266188585 618 dbSNP
rs1282870534 629 dbSNP
rs1023278652 631 dbSNP
rs970410772 634 dbSNP
rs982419249 635 dbSNP
rs1177756021 636 dbSNP
rs1045715506 646 dbSNP
rs907033931 647 dbSNP
rs1415017637 652 dbSNP
rs749531821 665 dbSNP
rs907827605 667 dbSNP
rs1441464055 673 dbSNP
rs527413867 674 dbSNP
rs1412998714 676 dbSNP
rs1161213137 679 dbSNP
rs1403587086 680 dbSNP
rs1411711748 700 dbSNP
rs1164352215 702 dbSNP
rs1475644494 706 dbSNP
rs1403030846 710 dbSNP
rs1031391405 712 dbSNP
rs1191907787 718 dbSNP
rs182143181 727 dbSNP
rs111784304 728 dbSNP
rs1218549766 730 dbSNP
rs761838383 734 dbSNP
rs533243051 743 dbSNP
rs59918631 744 dbSNP
rs1336438423 755 dbSNP
rs144239370 760 dbSNP
rs78968793 761 dbSNP
rs1362378316 768 dbSNP
rs1290482055 773 dbSNP
rs966146301 774 dbSNP
rs944076580 775 dbSNP
rs972216517 781 dbSNP
rs184347786 783 dbSNP
rs45445899 787 dbSNP
rs1325246492 797 dbSNP
rs1443542373 799 dbSNP
rs45486993 802 dbSNP
rs1168813010 809 dbSNP
rs930728988 811 dbSNP
rs902798678 813 dbSNP
rs867799717 814 dbSNP
rs1000192835 816 dbSNP
rs1213701527 823 dbSNP
rs915908141 827 dbSNP
rs1032490097 829 dbSNP
rs146575108 837 dbSNP
rs761131829 841 dbSNP
rs928545547 844 dbSNP
rs1204962640 845 dbSNP
rs1023413051 846 dbSNP
rs535688780 851 dbSNP
rs554381260 852 dbSNP
rs1003246708 853 dbSNP
rs572653180 869 dbSNP
rs1052937598 877 dbSNP
rs892988366 884 dbSNP
rs1461646506 887 dbSNP
rs1015013338 892 dbSNP
rs961950128 895 dbSNP
rs763918288 897 dbSNP
rs973311492 901 dbSNP
rs1394941889 904 dbSNP
rs1011317524 914 dbSNP
rs1476457017 917 dbSNP
rs2273780 928 dbSNP
rs953240326 930 dbSNP
rs985489528 932 dbSNP
rs1480726049 960 dbSNP
rs911345783 968 dbSNP
rs1477288061 969 dbSNP
rs539971396 971 dbSNP
rs944028497 975 dbSNP
rs1207680865 976 dbSNP
rs1189335336 983 dbSNP
rs889408260 990 dbSNP
rs1007854528 991 dbSNP
rs1236402267 997 dbSNP
rs766736257 1000 dbSNP
rs1307155159 1001 dbSNP
rs1390919167 1003 dbSNP
rs369843484 1004 dbSNP
rs923939846 1006 dbSNP
rs754145236 1009 dbSNP
rs1410812891 1017 dbSNP
rs1464782021 1026 dbSNP
rs966283713 1030 dbSNP
rs1333953648 1031 dbSNP
rs1437100828 1037 dbSNP
rs759884939 1038 dbSNP
rs993736031 1040 dbSNP
rs1357909286 1046 dbSNP
rs1180412337 1047 dbSNP
rs1054069926 1048 dbSNP
rs139737105 1051 dbSNP
rs1252158698 1054 dbSNP
rs1012460964 1059 dbSNP
rs751429988 1064 dbSNP
rs952348862 1065 dbSNP
rs576404999 1066 dbSNP
rs984893234 1073 dbSNP
rs1212821692 1076 dbSNP
rs1351357144 1078 dbSNP
rs1216890795 1083 dbSNP
rs45527633 1086 dbSNP
rs1238344564 1087 dbSNP
rs906250360 1092 dbSNP
rs1003708607 1094 dbSNP
rs1014570592 1096 dbSNP
rs1280266782 1098 dbSNP
rs375761979 1110 dbSNP
rs994697617 1114 dbSNP
rs1214891549 1115 dbSNP
rs915983915 1123 dbSNP
rs1277713286 1131 dbSNP
rs1027549817 1132 dbSNP
rs953211687 1133 dbSNP
rs543752201 1141 dbSNP
rs562648261 1149 dbSNP
rs1257586093 1151 dbSNP
rs911721477 1155 dbSNP
rs899145564 1156 dbSNP
rs45622332 1157 dbSNP
rs1454817446 1159 dbSNP
rs1190880464 1160 dbSNP
rs1425270986 1161 dbSNP
rs45576440 1163 dbSNP
rs1411670321 1165 dbSNP
rs995468069 1165 dbSNP
rs45542132 1167 dbSNP
rs1423596597 1179 dbSNP
rs981454884 1181 dbSNP
rs928513828 1183 dbSNP
rs1260843935 1188 dbSNP
rs1313962407 1196 dbSNP
rs934550366 1198 dbSNP
rs977255012 1214 dbSNP
rs189236198 1215 dbSNP
rs1334389975 1220 dbSNP
rs1300141575 1221 dbSNP
rs866346218 1225 dbSNP
rs1338886894 1227 dbSNP
rs116283028 1230 dbSNP
rs752367262 1241 dbSNP
rs915532720 1255 dbSNP
rs1291244724 1258 dbSNP
rs1007823639 1262 dbSNP
rs1418047225 1272 dbSNP
rs948295138 1276 dbSNP
rs1166625896 1285 dbSNP
rs1476672650 1309 dbSNP
rs1045218956 1311 dbSNP
rs1274022417 1313 dbSNP
rs1040667606 1317 dbSNP
rs1193690107 1317 dbSNP
rs1265221615 1330 dbSNP
rs1211823376 1331 dbSNP
rs1468101253 1339 dbSNP
rs896857246 1341 dbSNP
rs906714311 1343 dbSNP
rs527474164 1344 dbSNP
rs1215785825 1348 dbSNP
rs61612924 1360 dbSNP
rs1269956742 1370 dbSNP
rs1228646147 1371 dbSNP
rs1036548386 1372 dbSNP
rs1301888769 1373 dbSNP
rs757865112 1375 dbSNP
rs3742912 1379 dbSNP
rs1006808541 1380 dbSNP
rs1327376921 1384 dbSNP
rs1027520428 1390 dbSNP
rs1263277086 1392 dbSNP
rs1168242354 1401 dbSNP
rs888998678 1407 dbSNP
rs3742913 1408 dbSNP
rs541985823 1409 dbSNP
rs1007432496 1410 dbSNP
rs1479172808 1418 dbSNP
rs1018756054 1419 dbSNP
rs966301414 1422 dbSNP
rs1436244318 1423 dbSNP
rs976845776 1424 dbSNP
rs1035684057 1425 dbSNP
rs1380173938 1426 dbSNP
rs751544588 1428 dbSNP
rs1234159114 1431 dbSNP
rs3742914 1433 dbSNP
rs989449162 1439 dbSNP
rs538933648 1449 dbSNP
rs1385846358 1456 dbSNP
rs948262563 1466 dbSNP
rs1411361520 1467 dbSNP
rs557274944 1477 dbSNP
rs1172825030 1478 dbSNP
rs145798773 1486 dbSNP
rs943778279 1488 dbSNP
rs148985334 1492 dbSNP
rs781285346 1496 dbSNP
rs1442773044 1517 dbSNP
rs769599437 1518 dbSNP
rs1232461211 1519 dbSNP
rs896826239 1520 dbSNP
rs929636285 1523 dbSNP
rs867329536 1526 dbSNP
rs79460286 1529 dbSNP
rs888039633 1532 dbSNP
rs930402818 1539 dbSNP
rs1350698221 1550 dbSNP
rs1349312899 1558 dbSNP
rs1279694018 1582 dbSNP
rs1443885666 1584 dbSNP
rs1006367123 1593 dbSNP
rs80262145 1601 dbSNP
rs566315460 1607 dbSNP
rs1469552746 1614 dbSNP
rs1316154940 1615 dbSNP
rs147757192 1617 dbSNP
rs1400107993 1623 dbSNP
rs1407305008 1627 dbSNP
rs1194633031 1628 dbSNP
rs1471250440 1629 dbSNP
rs1237994186 1632 dbSNP
rs558285075 1634 dbSNP
rs34130244 1647 dbSNP
rs888799261 1653 dbSNP
rs1007419347 1654 dbSNP
rs558808751 1658 dbSNP
rs956032053 1659 dbSNP
rs1364892271 1660 dbSNP
rs901674194 1661 dbSNP
rs1332167318 1665 dbSNP
rs141113901 1670 dbSNP
rs537064652 1671 dbSNP
rs1400733979 1672 dbSNP
rs1161563597 1673 dbSNP
rs1021516505 1679 dbSNP
rs969020427 1680 dbSNP
rs1319017794 1681 dbSNP
rs1458888326 1685 dbSNP
rs536812912 1705 dbSNP
rs1164460432 1710 dbSNP
rs761185178 1711 dbSNP
rs989584788 1713 dbSNP
rs181239668 1717 dbSNP
rs1375954577 1718 dbSNP
rs911049578 1735 dbSNP
rs1217228830 1736 dbSNP
rs573936416 1743 dbSNP
rs1444328730 1749 dbSNP
rs372662734 1752 dbSNP
rs1272056525 1758 dbSNP
rs541763428 1762 dbSNP
rs1213929935 1764 dbSNP
rs1336553404 1771 dbSNP
rs575549912 1775 dbSNP
rs1293112944 1777 dbSNP
rs969404902 1783 dbSNP
rs981027326 1795 dbSNP
rs1362487171 1796 dbSNP
rs1271868891 1797 dbSNP
rs1336310452 1799 dbSNP
rs1368869179 1800 dbSNP
rs1325353250 1803 dbSNP
rs1462143629 1807 dbSNP
rs1351859774 1808 dbSNP
rs1168730522 1811 dbSNP
rs943914452 1812 dbSNP
rs976434680 1815 dbSNP
rs918343759 1816 dbSNP
rs571912935 1817 dbSNP
rs939525654 1818 dbSNP
rs1336454663 1819 dbSNP
rs1214004696 1830 dbSNP
rs1048554708 1846 dbSNP
rs888143815 1847 dbSNP
rs1203482190 1851 dbSNP
rs1307844637 1853 dbSNP
rs942267255 1854 dbSNP
rs1044706639 1857 dbSNP
rs545555700 1865 dbSNP
rs919428630 1866 dbSNP
rs930370080 1871 dbSNP
rs1441775951 1874 dbSNP
rs1048809014 1876 dbSNP
rs1296683373 1877 dbSNP
rs888764795 1880 dbSNP
rs1355478065 1881 dbSNP
rs1420159978 1884 dbSNP
rs1475652462 1885 dbSNP
rs1433380765 1893 dbSNP
rs1170169842 1894 dbSNP
rs1173639720 1895 dbSNP
rs1434407848 1896 dbSNP
rs891891876 1898 dbSNP
rs943069117 1900 dbSNP
rs1040284183 1908 dbSNP
rs901723675 1920 dbSNP
rs1022029078 1921 dbSNP
rs998788180 1928 dbSNP
rs1208494739 1933 dbSNP
rs1053341113 1938 dbSNP
rs1347009185 1941 dbSNP
rs1280963610 1943 dbSNP
rs1235041595 1945 dbSNP
rs1305046693 1948 dbSNP
rs892989312 1948 dbSNP
rs564044129 1949 dbSNP
rs1022410387 1951 dbSNP
rs969373840 1952 dbSNP
rs1002647654 1954 dbSNP
rs1413322907 1958 dbSNP
rs1375309889 1960 dbSNP
rs1035034851 1962 dbSNP
rs1468088736 1965 dbSNP
rs1356877445 1972 dbSNP
rs147982176 1977 dbSNP
rs1419250832 1988 dbSNP
rs531411149 2002 dbSNP
rs1315710105 2003 dbSNP
rs1311780253 2004 dbSNP
rs972360643 2012 dbSNP
rs976568835 2015 dbSNP
rs1202107190 2016 dbSNP
rs919397506 2022 dbSNP
rs1483189827 2025 dbSNP
rs952238646 2026 dbSNP
rs984504287 2027 dbSNP
rs750458860 2029 dbSNP
rs185808601 2032 dbSNP
rs1290456656 2033 dbSNP
rs141666125 2044 dbSNP
rs1193084751 2066 dbSNP
rs1355218132 2068 dbSNP
rs1294330565 2073 dbSNP
rs1398282155 2076 dbSNP
rs943141991 2083 dbSNP
rs1430570161 2090 dbSNP
rs528885359 2092 dbSNP
rs548153484 2100 dbSNP
rs1453860790 2109 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Disease 64093.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM714645. RNA binding protein: AGO2. Condition:completeT1 ...

- Kishore S; Jaskiewicz L; Burger L; Hausser et al., 2011, Nature methods.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' uaggagauuuuucuACGUGAAa 5'
                        ||||||| 
Target 5' -------------uUGCACUUu 3'
 		1 - 9
Article - Kishore S; Jaskiewicz L; Burger L; Hausser et al.
- Nature methods, 2011
Cross-linking and immunoprecipitation (CLIP) is increasingly used to map transcriptome-wide binding sites of RNA-binding proteins. We developed a method for CLIP data analysis, and applied it to compare CLIP with photoactivatable ribonucleoside-enhanced CLIP (PAR-CLIP) and to uncover how differences in cross-linking and ribonuclease digestion affect the identified sites. We found only small differences in accuracies of these methods in identifying binding sites of HuR, which binds low-complexity sequences, and Argonaute 2, which has a complex binding specificity. We found that cross-link-induced mutations led to single-nucleotide resolution for both PAR-CLIP and CLIP. Our results confirm the expectation from original CLIP publications that RNA-binding proteins do not protect their binding sites sufficiently under the denaturing conditions used during the CLIP procedure, and we show that extensive digestion with sequence-specific RNases strongly biases the recovered binding sites. This bias can be substantially reduced by milder nuclease digestion conditions.
LinkOut: [PMID: 21572407]
CLIP-seq Support 1 for dataset GSM714645
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / completeT1, repB
Location of target site ENST00000381280.4 | 3UTR | UUGCACUUUUAAUAACUCUUACUUGC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 21572407 / GSE28865
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE28260 Renal cortex and medulla 0.902 1.2e-5 0.780 8.3e-4 13 Click to see details
GSE28544 Breast cancer -0.591 1.2e-3 -0.542 3.1e-3 24 Click to see details
GSE42095 Differentiated embryonic stem cells -0.44 1.8e-2 -0.774 7.3e-6 23 Click to see details
GSE21687 Ependynoma primary tumors -0.188 6.8e-2 -0.084 2.5e-1 64 Click to see details
GSE26953 Aortic valvular endothelial cells 0.283 9.0e-2 0.304 7.4e-2 24 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis -0.217 1.8e-1 0.177 2.3e-1 20 Click to see details
GSE27834 Pluripotent stem cells 0.244 1.8e-1 0.324 1.1e-1 16 Click to see details
GSE32688 Pancreatic cancer 0.152 2.0e-1 0.011 4.8e-1 32 Click to see details
GSE35602 Colorectal cancer stromal tissue -0.138 2.6e-1 0.354 4.1e-2 25 Click to see details
GSE38974 Chronic obstructive pulmonary disease 0.121 2.8e-1 -0.218 1.5e-1 25 Click to see details
GSE15076 Monocyte-derived dendritic cells 0.235 2.9e-1 0.333 2.1e-1 8 Click to see details
GSE17306 Multiple myeloma -0.08 2.9e-1 0.445 6.8e-4 49 Click to see details
GSE19350 CNS germ cell tumors -0.121 3.5e-1 0.044 4.5e-1 12 Click to see details
GSE38226 Liver fibrosis 0.061 4.0e-1 -0.129 2.9e-1 21 Click to see details
GSE14794 Lymphoblastoid cells 0.018 4.3e-1 0.033 3.8e-1 90 Click to see details
GSE14794 Lymphoblastoid cells 0.018 4.3e-1 0.033 3.8e-1 90 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
BRCA 0.614 0.14 0.700 0.09 5 Click to see details
HNSC -0.701 0.25 -0.500 0.33 3 Click to see details
LIHC -0.176 0.41 -0.400 0.3 4 Click to see details
LIHC -0.176 0.41 -0.400 0.3 4 Click to see details
LIHC -0.176 0.41 -0.400 0.3 4 Click to see details
LIHC -0.176 0.41 -0.400 0.3 4 Click to see details
325 hsa-miR-519c-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT000496 HIF1A hypoxia inducible factor 1 alpha subunit 4 1
MIRT000998 ABCG2 ATP binding cassette subfamily G member 2 (Junior blood group) 4 3
MIRT003732 ELAVL1 ELAV like RNA binding protein 1 3 1
MIRT006639 TIMP2 TIMP metallopeptidase inhibitor 2 3 1
MIRT006640 PTEN phosphatase and tensin homolog 3 1
MIRT006641 CDKN1A cyclin dependent kinase inhibitor 1A 3 1
MIRT055028 TPRG1L tumor protein p63 regulated 1 like 2 2
MIRT055393 SHOC2 SHOC2, leucine rich repeat scaffold protein 2 6
MIRT056828 REEP3 receptor accessory protein 3 2 2
MIRT060504 PPP6R3 protein phosphatase 6 regulatory subunit 3 2 2
MIRT061796 PPP1R15B protein phosphatase 1 regulatory subunit 15B 2 10
MIRT063354 ETNK1 ethanolamine kinase 1 2 2
MIRT064424 ARID4B AT-rich interaction domain 4B 2 2
MIRT064719 CCND2 cyclin D2 2 2
MIRT064805 ZBTB18 zinc finger and BTB domain containing 18 2 4
MIRT065609 DAZAP2 DAZ associated protein 2 2 10
MIRT065622 CLIC4 chloride intracellular channel 4 2 4
MIRT065872 GDF11 growth differentiation factor 11 2 2
MIRT065892 RAB5B RAB5B, member RAS oncogene family 2 8
MIRT068751 RB1 RB transcriptional corepressor 1 2 2
MIRT070050 FANCM Fanconi anemia complementation group M 2 2
MIRT071004 SMOC1 SPARC related modular calcium binding 1 2 2
MIRT071334 CMPK1 cytidine/uridine monophosphate kinase 1 2 6
MIRT071912 ZFYVE9 zinc finger FYVE-type containing 9 2 2
MIRT072732 GLCE glucuronic acid epimerase 2 2
MIRT076028 COX10 COX10, heme A:farnesyltransferase cytochrome c oxidase assembly factor 2 6
MIRT076046 PITPNA phosphatidylinositol transfer protein alpha 2 2
MIRT079353 CCDC137 coiled-coil domain containing 137 2 2
MIRT080227 SMAD4 SMAD family member 4 2 6
MIRT081122 LDLR low density lipoprotein receptor 2 8
MIRT081205 MIDN midnolin 2 10
MIRT085098 IFNAR2 interferon alpha and beta receptor subunit 2 2 6
MIRT085149 SLC5A3 solute carrier family 5 member 3 2 4
MIRT086436 NABP1 nucleic acid binding protein 1 2 6
MIRT088037 UBXN2A UBX domain protein 2A 2 2
MIRT088132 SEPT2 septin 2 2 4
MIRT088343 MAPRE3 microtubule associated protein RP/EB family member 3 2 8
MIRT090645 U2SURP U2 snRNP associated SURP domain containing 2 6
MIRT090805 MBNL1 muscleblind like splicing regulator 1 2 4
MIRT091692 TGFBR2 transforming growth factor beta receptor 2 2 4
MIRT092689 C3ORF38 chromosome 3 open reading frame 38 2 8
MIRT093954 SLAIN2 SLAIN motif family member 2 2 2
MIRT095727 ANKH ANKH inorganic pyrophosphate transport regulator 2 8
MIRT097158 FCHO2 FCH domain only 2 2 2
MIRT099319 QKI QKI, KH domain containing RNA binding 2 4
MIRT099835 SOX4 SRY-box 4 2 10
MIRT100773 ENPP4 ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative) 2 2
MIRT100955 CENPQ centromere protein Q 2 4
MIRT102229 HBP1 HMG-box transcription factor 1 2 2
MIRT102299 DNAJB9 DnaJ heat shock protein family (Hsp40) member B9 2 10
MIRT102621 UBN2 ubinuclein 2 2 8
MIRT103780 PURB purine rich element binding protein B 2 2
MIRT104168 PHTF2 putative homeodomain transcription factor 2 2 6
MIRT107279 FAM73B mitoguardin 2 2 2
MIRT107945 TMEM2 transmembrane protein 2 2 2
MIRT108265 HABP4 hyaluronan binding protein 4 2 2
MIRT124812 BICD2 BICD cargo adaptor 2 2 2
MIRT138707 MPP5 membrane palmitoylated protein 5 2 2
MIRT139880 BTF3L4 basic transcription factor 3 like 4 2 6
MIRT144312 NFAT5 nuclear factor of activated T-cells 5 2 8
MIRT145605 LASP1 LIM and SH3 protein 1 2 2
MIRT153350 MAVS mitochondrial antiviral signaling protein 2 4
MIRT153986 PRNP prion protein 2 2
MIRT159129 NRBP1 nuclear receptor binding protein 1 2 2
MIRT164533 MSMO1 methylsterol monooxygenase 1 2 2
MIRT165912 CREBRF CREB3 regulatory factor 2 2
MIRT170858 TAX1BP1 Tax1 binding protein 1 2 4
MIRT172157 FZD6 frizzled class receptor 6 2 8
MIRT173701 PRPF4 pre-mRNA processing factor 4 2 2
MIRT175003 ZBTB5 zinc finger and BTB domain containing 5 2 4
MIRT175400 ACSL4 acyl-CoA synthetase long chain family member 4 2 2
MIRT178069 SAMD8 sterile alpha motif domain containing 8 2 2
MIRT178675 FAM102B family with sequence similarity 102 member B 2 2
MIRT180847 RPRD2 regulation of nuclear pre-mRNA domain containing 2 2 4
MIRT194911 RBBP6 RB binding protein 6, ubiquitin ligase 2 8
MIRT195755 ATMIN ATM interactor 2 6
MIRT196623 TAOK1 TAO kinase 1 2 6
MIRT205286 STK11IP serine/threonine kinase 11 interacting protein 2 2
MIRT206051 PPARA peroxisome proliferator activated receptor alpha 2 2
MIRT206198 RAB10 RAB10, member RAS oncogene family 2 4
MIRT208980 SKIL SKI like proto-oncogene 2 10
MIRT223637 ATP6V1C1 ATPase H+ transporting V1 subunit C1 2 4
MIRT224757 DPYSL2 dihydropyrimidinase like 2 2 2
MIRT227995 NFIB nuclear factor I B 2 4
MIRT230973 PRRG4 proline rich and Gla domain 4 2 2
MIRT238183 ANKRD33B ankyrin repeat domain 33B 2 10
MIRT242425 HAS3 hyaluronan synthase 3 2 2
MIRT242666 SALL3 spalt like transcription factor 3 2 4
MIRT242765 FNBP1L formin binding protein 1 like 2 6
MIRT243095 LCLAT1 lysocardiolipin acyltransferase 1 2 4
MIRT243437 PAK2 p21 (RAC1) activated kinase 2 2 2
MIRT243964 MAP1B microtubule associated protein 1B 2 2
MIRT244776 RABGAP1 RAB GTPase activating protein 1 2 2
MIRT246630 TMEM109 transmembrane protein 109 2 2
MIRT246968 TSKU tsukushi, small leucine rich proteoglycan 2 2
MIRT266055 FJX1 four jointed box 1 2 4
MIRT266858 SLC25A44 solute carrier family 25 member 44 2 2
MIRT283184 C16ORF52 chromosome 16 open reading frame 52 2 2
MIRT286955 SOCS7 suppressor of cytokine signaling 7 2 2
MIRT293651 PVR poliovirus receptor 2 4
MIRT295178 ZNF317 zinc finger protein 317 2 4
MIRT302453 CLIP4 CAP-Gly domain containing linker protein family member 4 2 2
MIRT303499 NAGK N-acetylglucosamine kinase 2 6
MIRT368755 CDADC1 cytidine and dCMP deaminase domain containing 1 2 2
MIRT383207 APH1A aph-1 homolog A, gamma-secretase subunit 2 2
MIRT383610 POU2F1 POU class 2 homeobox 1 2 2
MIRT396102 CASP2 caspase 2 2 2
MIRT441419 FAM9C family with sequence similarity 9 member C 2 2
MIRT446818 C5orf30 chromosome 5 open reading frame 30 2 2
MIRT448307 WNK3 WNK lysine deficient protein kinase 3 2 2
MIRT461781 MPDU1 mannose-P-dolichol utilization defect 1 2 2
MIRT462816 NTN1 netrin 1 2 2
MIRT463613 ZBTB34 zinc finger and BTB domain containing 34 2 2
MIRT464560 UBTF upstream binding transcription factor, RNA polymerase I 2 2
MIRT464842 RPS27A ribosomal protein S27a 2 12
MIRT465225 TRIP10 thyroid hormone receptor interactor 10 2 2
MIRT466446 TFAM transcription factor A, mitochondrial 2 8
MIRT466836 STX6 syntaxin 6 2 6
MIRT467185 SPTY2D1 SPT2 chromatin protein domain containing 1 2 2
MIRT468179 SGMS1 sphingomyelin synthase 1 2 2
MIRT469850 PXK PX domain containing serine/threonine kinase like 2 8
MIRT471612 PAQR5 progestin and adipoQ receptor family member 5 2 19
MIRT472008 NR1D2 nuclear receptor subfamily 1 group D member 2 2 2
MIRT472159 NIN ninein 2 4
MIRT472336 NETO2 neuropilin and tolloid like 2 2 4
MIRT473162 MLLT1 MLLT1, super elongation complex subunit 2 2
MIRT473623 MARK2 microtubule affinity regulating kinase 2 2 2
MIRT473682 MAPKBP1 mitogen-activated protein kinase binding protein 1 2 2
MIRT473805 MAP3K2 mitogen-activated protein kinase kinase kinase 2 2 2
MIRT474416 KLHL28 kelch like family member 28 2 8
MIRT474736 KIF13A kinesin family member 13A 2 6
MIRT474966 KCTD10 potassium channel tetramerization domain containing 10 2 4
MIRT475464 HSPA8 heat shock protein family A (Hsp70) member 8 2 6
MIRT476120 GPR157 G protein-coupled receptor 157 2 2
MIRT476203 GNS glucosamine (N-acetyl)-6-sulfatase 2 6
MIRT477180 F3 coagulation factor III, tissue factor 2 8
MIRT478103 DLG5 discs large MAGUK scaffold protein 5 2 6
MIRT478713 CSNK1A1 casein kinase 1 alpha 1 2 6
MIRT479055 CNOT6L CCR4-NOT transcription complex subunit 6 like 2 8
MIRT480008 CAPRIN2 caprin family member 2 2 4
MIRT480519 C11orf30 EMSY, BRCA2 interacting transcriptional repressor 2 10
MIRT480822 BLCAP bladder cancer associated protein 2 10
MIRT480944 BBX BBX, HMG-box containing 2 8
MIRT481336 ATL3 atlastin GTPase 3 2 2
MIRT481598 ARHGAP1 Rho GTPase activating protein 1 2 6
MIRT481877 ANKRD50 ankyrin repeat domain 50 2 2
MIRT482471 ADAR adenosine deaminase, RNA specific 2 4
MIRT484875 ZNF652 zinc finger protein 652 2 2
MIRT485090 SLC30A1 solute carrier family 30 member 1 2 4
MIRT485579 FOXQ1 forkhead box Q1 2 2
MIRT485618 FBXL5 F-box and leucine rich repeat protein 5 2 10
MIRT486751 CNOT4 CCR4-NOT transcription complex subunit 4 2 6
MIRT489599 ZDHHC20 zinc finger DHHC-type containing 20 2 10
MIRT489889 MPLKIP M-phase specific PLK1 interacting protein 2 2
MIRT491654 PDRG1 p53 and DNA damage regulated 1 2 10
MIRT492038 TSG101 tumor susceptibility 101 2 4
MIRT492361 SEMA7A semaphorin 7A (John Milton Hagen blood group) 2 2
MIRT492776 PDGFB platelet derived growth factor subunit B 2 2
MIRT493336 LAPTM4A lysosomal protein transmembrane 4 alpha 2 12
MIRT493611 HMGB3 high mobility group box 3 2 6
MIRT497468 DDR2 discoidin domain receptor tyrosine kinase 2 2 2
MIRT498059 SNX5 sorting nexin 5 2 6
MIRT499901 KIAA1191 KIAA1191 2 4
MIRT500489 ZBTB4 zinc finger and BTB domain containing 4 2 6
MIRT500685 TRIM37 tripartite motif containing 37 2 2
MIRT500760 TMEM127 transmembrane protein 127 2 6
MIRT501456 PTPN4 protein tyrosine phosphatase, non-receptor type 4 2 8
MIRT501559 POC1B-GALNT4 POC1B-GALNT4 readthrough 2 2
MIRT501983 MAPK1 mitogen-activated protein kinase 1 2 10
MIRT502000 MAP7 microtubule associated protein 7 2 8
MIRT502049 LAMTOR1 late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 2 6
MIRT502423 GALNT4 polypeptide N-acetylgalactosaminyltransferase 4 2 2
MIRT503044 CAMSAP2 calmodulin regulated spectrin associated protein family member 2 2 2
MIRT503821 TMEM242 transmembrane protein 242 2 4
MIRT504290 PARP1 poly(ADP-ribose) polymerase 1 2 6
MIRT504560 ZNF417 zinc finger protein 417 2 6
MIRT505054 ZNF202 zinc finger protein 202 2 6
MIRT505486 SRSF2 serine and arginine rich splicing factor 2 2 4
MIRT505836 POLR1B RNA polymerase I subunit B 2 4
MIRT506372 NUFIP2 NUFIP2, FMR1 interacting protein 2 2 4
MIRT506451 NACC2 NACC family member 2 2 4
MIRT506673 LZIC leucine zipper and CTNNBIP1 domain containing 2 4
MIRT506834 KIF23 kinesin family member 23 2 4
MIRT506880 KIAA0101 PCNA clamp associated factor 2 6
MIRT507359 FAM129A family with sequence similarity 129 member A 2 6
MIRT507957 BNIP2 BCL2 interacting protein 2 2 6
MIRT509433 MCM7 minichromosome maintenance complex component 7 2 6
MIRT510872 RAN RAN, member RAS oncogene family 2 8
MIRT511078 NIPA1 non imprinted in Prader-Willi/Angelman syndrome 1 2 4
MIRT511254 KLHL36 kelch like family member 36 2 6
MIRT513699 RBM20 RNA binding motif protein 20 2 4
MIRT513742 PKNOX1 PBX/knotted 1 homeobox 1 2 2
MIRT513981 CEP97 centrosomal protein 97 2 2
MIRT514092 EPS15L1 epidermal growth factor receptor pathway substrate 15 like 1 2 6
MIRT515928 MFAP2 microfibril associated protein 2 2 4
MIRT519574 ZNFX1 zinc finger NFX1-type containing 1 2 4
MIRT521297 RRAGD Ras related GTP binding D 2 4
MIRT521348 RPP14 ribonuclease P/MRP subunit p14 2 2
MIRT521693 PRKAA1 protein kinase AMP-activated catalytic subunit alpha 1 2 8
MIRT521778 PPIG peptidylprolyl isomerase G 2 8
MIRT522191 NR2C2 nuclear receptor subfamily 2 group C member 2 2 6
MIRT524696 BTG3 BTG anti-proliferation factor 3 2 8
MIRT525663 NHSL2 NHS like 2 2 2
MIRT527252 TMEM196 transmembrane protein 196 2 2
MIRT527466 CLEC12B C-type lectin domain family 12 member B 2 2
MIRT529535 ICMT isoprenylcysteine carboxyl methyltransferase 2 2
MIRT530146 HADHB hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit 2 2
MIRT530851 RAG1 recombination activating 1 2 4
MIRT531109 PEX13 peroxisomal biogenesis factor 13 2 2
MIRT534263 SLC12A7 solute carrier family 12 member 7 2 2
MIRT534756 RASGEF1A RasGEF domain family member 1A 2 2
MIRT535175 PLEKHB2 pleckstrin homology domain containing B2 2 2
MIRT535246 PIGA phosphatidylinositol glycan anchor biosynthesis class A 2 4
MIRT535401 PER1 period circadian clock 1 2 2
MIRT536036 MCUR1 mitochondrial calcium uniporter regulator 1 2 2
MIRT536347 LEFTY1 left-right determination factor 1 2 2
MIRT536413 KREMEN1 kringle containing transmembrane protein 1 2 2
MIRT536437 KMT2B lysine methyltransferase 2B 2 6
MIRT536604 IRF2 interferon regulatory factor 2 2 2
MIRT536642 INO80D INO80 complex subunit D 2 2
MIRT536860 HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 2 2
MIRT537241 GALNT3 polypeptide N-acetylgalactosaminyltransferase 3 2 2
MIRT537728 ELAVL2 ELAV like RNA binding protein 2 2 2
MIRT537988 DPP8 dipeptidyl peptidase 8 2 2
MIRT538037 DNAJB6 DnaJ heat shock protein family (Hsp40) member B6 2 2
MIRT538255 CUL3 cullin 3 2 4
MIRT538525 CLCN3 chloride voltage-gated channel 3 2 2
MIRT538659 CCSAP centriole, cilia and spindle associated protein 2 2
MIRT538779 C7orf60 base methyltransferase of 25S rRNA 2 homolog 2 4
MIRT538849 BTG1 BTG anti-proliferation factor 1 2 2
MIRT538923 BRI3BP BRI3 binding protein 2 6
MIRT539114 ARL10 ADP ribosylation factor like GTPase 10 2 2
MIRT539454 ADARB2 adenosine deaminase, RNA specific B2 (inactive) 2 2
MIRT541085 RLIM ring finger protein, LIM domain interacting 2 2
MIRT543117 SKA2 spindle and kinetochore associated complex subunit 2 2 2
MIRT543181 FICD FIC domain containing 2 2
MIRT543575 RPF2 ribosome production factor 2 homolog 2 4
MIRT544113 IPMK inositol polyphosphate multikinase 2 2
MIRT544625 CSDE1 cold shock domain containing E1 2 2
MIRT544699 ZNF224 zinc finger protein 224 2 4
MIRT544992 MFF mitochondrial fission factor 2 4
MIRT546248 TNFRSF21 TNF receptor superfamily member 21 2 2
MIRT546282 TMEM30A transmembrane protein 30A 2 4
MIRT546290 TMEM200C transmembrane protein 200C 2 4
MIRT546558 SATB2 SATB homeobox 2 2 2
MIRT546815 RAP2C RAP2C, member of RAS oncogene family 2 2
MIRT547046 POGZ pogo transposable element derived with ZNF domain 2 2
MIRT547474 MBNL3 muscleblind like splicing regulator 3 2 4
MIRT547761 KATNAL1 katanin catalytic subunit A1 like 1 2 2
MIRT547892 HSPA13 heat shock protein family A (Hsp70) member 13 2 2
MIRT548315 EPHA4 EPH receptor A4 2 2
MIRT548383 ENPP5 ectonucleotide pyrophosphatase/phosphodiesterase 5 (putative) 2 4
MIRT548460 EGLN3 egl-9 family hypoxia inducible factor 3 2 2
MIRT548579 DNAJB14 DnaJ heat shock protein family (Hsp40) member B14 2 2
MIRT548858 CERCAM cerebral endothelial cell adhesion molecule 2 2
MIRT548896 CHEK2 checkpoint kinase 2 2 4
MIRT549319 ARHGAP12 Rho GTPase activating protein 12 2 4
MIRT550302 ZNF681 zinc finger protein 681 2 2
MIRT551120 ZNF107 zinc finger protein 107 2 2
MIRT551406 DCTPP1 dCTP pyrophosphatase 1 2 2
MIRT552173 DAD1 defender against cell death 1 2 2
MIRT552856 WIPF2 WAS/WASL interacting protein family member 2 2 2
MIRT552892 WASL Wiskott-Aldrich syndrome like 2 4
MIRT553075 UEVLD UEV and lactate/malate dehyrogenase domains 2 2
MIRT553668 TFAP4 transcription factor AP-4 2 4
MIRT553700 TCF7L2 transcription factor 7 like 2 2 2
MIRT554608 RPS6KA5 ribosomal protein S6 kinase A5 2 2
MIRT554860 RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis) 2 2
MIRT556157 MECP2 methyl-CpG binding protein 2 2 2
MIRT556179 MCC mutated in colorectal cancers 2 2
MIRT556529 LIN52 lin-52 DREAM MuvB core complex component 2 2
MIRT556723 KLHL21 kelch like family member 21 2 4
MIRT557054 HOXB3 homeobox B3 2 2
MIRT557587 GNPTAB N-acetylglucosamine-1-phosphate transferase alpha and beta subunits 2 2
MIRT557661 GATA6 GATA binding protein 6 2 2
MIRT557753 FRS2 fibroblast growth factor receptor substrate 2 2 2
MIRT557881 FEM1B fem-1 homolog B 2 4
MIRT558215 EFCAB14 EF-hand calcium binding domain 14 2 4
MIRT558264 DYNC1LI2 dynein cytoplasmic 1 light intermediate chain 2 2 2
MIRT558327 DNAJC28 DnaJ heat shock protein family (Hsp40) member C28 2 4
MIRT558766 CFL2 cofilin 2 2 2
MIRT561037 ASB6 ankyrin repeat and SOCS box containing 6 2 2
MIRT561324 ZBTB37 zinc finger and BTB domain containing 37 2 2
MIRT561641 RUNX3 runt related transcription factor 3 2 2
MIRT562555 CCDC71L coiled-coil domain containing 71 like 2 4
MIRT562961 LRPAP1 LDL receptor related protein associated protein 1 2 2
MIRT564680 ZNF35 zinc finger protein 35 2 2
MIRT565694 SESN3 sestrin 3 2 2
MIRT565910 SCAMP2 secretory carrier membrane protein 2 2 2
MIRT566141 RACGAP1 Rac GTPase activating protein 1 2 2
MIRT567047 KCNB1 potassium voltage-gated channel subfamily B member 1 2 2
MIRT567076 KBTBD2 kelch repeat and BTB domain containing 2 2 2
MIRT567539 FGFR1OP FGFR1 oncogene partner 2 2
MIRT567624 FAM210A family with sequence similarity 210 member A 2 2
MIRT570321 ZNF70 zinc finger protein 70 2 2
MIRT571759 PSD3 pleckstrin and Sec7 domain containing 3 2 2
MIRT571857 NKIRAS1 NFKB inhibitor interacting Ras like 1 2 2
MIRT573372 LIMA1 LIM domain and actin binding 1 2 2
MIRT574561 NR2F2 nuclear receptor subfamily 2 group F member 2 2 2
MIRT614729 ATAT1 alpha tubulin acetyltransferase 1 2 4
MIRT617877 ESR1 estrogen receptor 1 2 2
MIRT624421 CBX8 chromobox 8 2 2
MIRT625865 SLC35C2 solute carrier family 35 member C2 2 2
MIRT630703 DICER1 dicer 1, ribonuclease III 2 4
MIRT632514 PTPN9 protein tyrosine phosphatase, non-receptor type 9 2 2
MIRT641797 USP32 ubiquitin specific peptidase 32 2 2
MIRT663625 SEC23B Sec23 homolog B, coat complex II component 2 2
MIRT680135 ADRBK2 G protein-coupled receptor kinase 3 2 2
MIRT702388 KLF10 Kruppel like factor 10 2 2
MIRT707830 TMEM133 transmembrane protein 133 2 2
MIRT708885 MOCS2 molybdenum cofactor synthesis 2 2 2
MIRT709122 C3orf18 chromosome 3 open reading frame 18 2 2
MIRT709635 KBTBD6 kelch repeat and BTB domain containing 6 2 2
MIRT710596 CDCA4 cell division cycle associated 4 2 2
MIRT710802 IFNLR1 interferon lambda receptor 1 2 2
MIRT711782 RFXAP regulatory factor X associated protein 2 2
MIRT713344 KLRD1 killer cell lectin like receptor D1 2 2
MIRT713640 MED8 mediator complex subunit 8 2 2
MIRT713916 IGF2R insulin like growth factor 2 receptor 2 2
MIRT715068 TMTC1 transmembrane and tetratricopeptide repeat containing 1 2 2
MIRT715206 FKTN fukutin 2 2
MIRT717819 FAM114A1 family with sequence similarity 114 member A1 2 2
MIRT720543 CHERP calcium homeostasis endoplasmic reticulum protein 2 2
MIRT720636 ELF5 E74 like ETS transcription factor 5 2 2
MIRT721703 ISY1 ISY1 splicing factor homolog 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-519c Bilobalide NULL 73581 Quantitative real-time PCR Human breast cancer MCF-7 cells 21796641 2011 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-519c Docetaxel+Cisplatin+5-Fluorouracil resistant tissue (hypopharyngeal squamous cell carcinoma)
hsa-miR-519c-3p Mitoxantrone 4212 NSC279836 approved sensitive Low Breast Cancer cell line (MCF-7)
hsa-miR-519c-3p Cisplatin 5460033 NSC119875 approved resistant High Germ Cell Tumor cell line (NTERA-2)
hsa-miR-519c-3p Vinorelbine 44424639 approved resistant High Non-Small Cell Lung Cancer cell line (H358, H1993)
hsa-miR-519c-3p Tamoxifen 2733525 NSC180973 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-519c-3p Gemcitabine 60750 NSC613327 approved sensitive Low Pancreatic Cancer cell line (MIA-PaCa-2)
hsa-miR-519c-3p Osimertinib 71496458 NSC779217 approved resistant cell line (PC9)
hsa-miR-519c-3p Vemurafenib 42611257 NSC761431 approved resistant cell line (451Lu)
hsa-miR-519c-3p Vemurafenib 42611257 NSC761431 approved resistant cell line (LM36)
hsa-miR-519c-3p Fluorouracil 3385 NSC19893 approved resistant cell line (KM12C) (72 h)
hsa-miR-519c-3p Sunitinib 5329102 NSC750690 approved resistant tissue (CardA)
hsa-miR-519c-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)

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