miRTarBase - #MIRT071388


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pre-miRNA Information
pre-miRNA hsa-mir-520e   
Genomic Coordinates chr19: 53675711 - 53675797
Description Homo sapiens miR-520e stem-loop
Comment None
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-520e
Sequence 54| AAAGUGCUUCCUUUUUGAGGG |74
Evidence Experimental
Experiments Array-cloned
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol CMPK1   
Synonyms CK, CMK, CMPK, UMK, UMP-CMPK, UMPK
Description cytidine/uridine monophosphate kinase 1
Transcript NM_001136140   
Other Transcripts NM_016308   
Expression
Putative miRNA Targets on CMPK1
3'UTR of CMPK1
(miRNA target sites are highlighted)		 
>CMPK1|NM_001136140|3'UTR
   1 TTCTAAACCTGAAGGCATCCTTGAAATCATGCTTGAATATTGCTTTGATAGCTGCTATCATGACCCCTTTTTAAGGCAAT
  81 TCTAATCTTTCATAACTACATCTCAATTAGTGGCTGGAAAGTACATGGTAAAACAAAGTAAATTTTTTTATGTTCTTTTT
 161 TTTGGTCACAGGAGTAGACAGTGAATTCAGGTTTAACTTCACCTTAGTTATGGTGCTCACCAAACGAAGGGTATCAGCTA
 241 TTTTTTTTAAAATTCAAAAAGAATATCCCTTTTATAGTTTGTGCCTTCTGTGAGCAAAACTTTTTAGTACGCGTATATAT
 321 CCCTCTAGTAATCACAACATTTTAGGATTTAGGGATACCCGCTTCCTCTTTTTCTTGCAAGTTTTAAATTTCCAACCTTA
 401 AGTGAATTTGTGGACCAAATTTCAAAGGAACTTTTTGTGTAGTCAGTTCTTGCACAATGTGTTTGGTAAACAAACTCAAA
 481 ATGGATTCTTAGGAGCATTTTAGTGTTTATTAAATAACTGACCATTTGCTGTAGAAAGATGAGAAAACTTAAGCTTTGTT
 561 TTACTACAACTTGTACAAAGTTGTATGACAGGGCATATTCTTTGCTTCCAAGATTTGGGTTGGGGGCACTAGGGGTTCAG
 641 AGCCTGGCAGAATTGTCAGCTTTAGTCTGACATAATCTAAGGGTATGGGGCAAGGATCACATCTAATGCTTGTGTTCCTT
 721 ATACTCTATTATATAGTGTTATTCATGATTCAGCTGATCTTAACAAAATTCGTAGCAGTGGAACCTTGAAATGCATGTGG
 801 CTAGATTTATGCTAAAATGATTCTCAGTTAGCATTTTAGTAACACTTCAAAGGTTTTTTTTTGTTTGTTTTCTAGACTTA
 881 ATAAAAGCTTAGGATTAATTAGAAGAAGCAATCTAGTTAAATTTCCCATTTGTATTTTATTTTCTTGAATACTTTTTTCA
 961 TAGTTATTTGTTTAAAAAGATTTAAAAATCATTGCACTTTGGTCAGAAAAATAATAAATATATCTTATAAATGTTTGATT
1041 CCCTTCCTTGCTATTTTTATTCAGTAGATTTTTGTTTGGCATCATGTTGAAGCACCGAAAGATAAATGATTTTTAAAAGG
1121 CTATAGAGTCCAAAGGAATATTCTTTTACACCAATTCTTCCTTTAAAAATCTCTGAGGAATTTGTTTTCGCCTTACTTTT
1201 TTTTCTTCTGTCACAATGCTAAGTGGTATCCGAGGTTCTTAATATGAGATTTAAAATCTTAAAATGTTTCTTATTTTCAG
1281 CACTTACATCATTTGGTACACAGGGTCAAATAGGGCAAATAATTTTGTCTTTGTATAATAGATTTGATATTTAAAGTCAC
1361 TGGAAATAGGACAAGTTAATGGATGTTTTTATATTTTAATAGAATCATTTATTTCTATGTGTTATGAAATTCACTTAATG
1441 ATAAATTTTTCAACATACTTGCCATTAGAAAACAAAGTATTGCTAAGTACTATAACATATTGGCCACTAAAATTCATATT
1521 GAGATTATCTTGGTTTCTTGGAAGAGATAGGAATGAGTTCTTATCTAGTGTTGCAGGCCAGCAAATACAGAGGTGGTTTA
1601 ATCAAACAGCTCTAGTATGAAGCAAGAGTAAAGACTAAGGTTTCGAGAGCATTCCTACTCACATAAGTGAAGAAATCTGT
1681 CAGATAGGAATCTAAATATTTATAGTGAGATTGTGAAAGCAACCTTAAAGTTTTGAAGAAGACTGATGAGACTAGGTGCT
1761 TTGCTTCCTTTCATCAGGTATCTTTCTGTGGCATTTGAGAACAGAAACCAAGAAACATGGTAATTACTAAATTATGAGGC
1841 TTTGCTTTTTGTTTGCTTTTAAGTAGAAAAACATGTTGGCAACATTGAGTTTTGGAGTTGATTGAGATAATATGACTTAA
1921 CTAGTTTTGTCATTCCATTTGTTAAAGATACAGTCACCAAGAATGTTTTGAGTTTTTTGAAAGACCCCAATTTAAGCCTT
2001 GCTTATTTTTAAATTATTTCCATTCAGTGATGTTGGATGTATATCAGTTATTTAGTAAATAATCTCAATAAATTTTGTGC
2081 TGTGGCCTTTGCTAAAAAAAAAAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' ggGAGUUUUUCCU--------UCGUGAAa 5'
            ||||||| |||        ||||:|| 
Target 5' aaCTCAAAATGGATTCTTAGGAGCATTTt 3'
 473 - 501 149.00 -15.10
2 
miRNA  3' ggGAGUUUUUC-----CU-----UCGUGAAa 5'
            ||:|||| |      |     ||||||| 
Target 5' atCTTAAAATGTTTCTTATTTTCAGCACTTa 3'
 1256 - 1286 143.00 -9.27
3 
miRNA  3' ggGAGUUUUUCCU-UCGUGAAa 5'
            :|:|||||  |  |||||| 
Target 5' gaTTTAAAAATCATTGCACTTt 3'
 979 - 1000 131.00 -9.80
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30123969 16 COSMIC
COSN31572823 45 COSMIC
COSN30178130 98 COSMIC
COSN30155879 105 COSMIC
COSN30166247 140 COSMIC
COSN31598991 141 COSMIC
COSN31570859 146 COSMIC
COSN30643319 150 COSMIC
COSN31581859 150 COSMIC
COSN29267317 156 COSMIC
COSN30127041 226 COSMIC
COSN31534627 227 COSMIC
COSN31534259 249 COSMIC
COSN31568855 251 COSMIC
COSN26548569 299 COSMIC
COSN24296915 338 COSMIC
COSN24296925 863 COSMIC
COSN31483235 863 COSMIC
COSN31596754 1004 COSMIC
COSN31577080 1039 COSMIC
COSN29468430 1087 COSMIC
COSN32056902 1143 COSMIC
COSN29707418 1205 COSMIC
COSN1446999 1319 COSMIC
COSN24294616 1650 COSMIC
COSN17794164 2004 COSMIC
COSN19090186 2046 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs3125648 15 dbSNP
rs867076992 16 dbSNP
rs1246062425 19 dbSNP
rs771523327 30 dbSNP
rs185243869 31 dbSNP
rs956424126 33 dbSNP
rs746725181 35 dbSNP
rs1421895087 41 dbSNP
rs770588462 42 dbSNP
rs1365801525 44 dbSNP
rs1334784300 48 dbSNP
rs1457794181 50 dbSNP
rs954262438 60 dbSNP
rs1292546352 63 dbSNP
rs1010365974 66 dbSNP
rs531332693 78 dbSNP
rs1390893055 80 dbSNP
rs543090281 85 dbSNP
rs1019903392 100 dbSNP
rs1276306505 101 dbSNP
rs191223317 113 dbSNP
rs781259877 114 dbSNP
rs1460930422 117 dbSNP
rs1373630579 119 dbSNP
rs1279804599 121 dbSNP
rs1309519228 126 dbSNP
rs927302631 127 dbSNP
rs1265068954 128 dbSNP
rs1159798060 135 dbSNP
rs952049969 139 dbSNP
rs913620566 141 dbSNP
rs529020626 142 dbSNP
rs907913601 152 dbSNP
rs1248040306 156 dbSNP
rs979061458 156 dbSNP
rs547975641 162 dbSNP
rs1488219533 169 dbSNP
rs1269381635 170 dbSNP
rs1211098038 184 dbSNP
rs566287088 191 dbSNP
rs922435459 192 dbSNP
rs113534701 203 dbSNP
rs1049617445 208 dbSNP
rs1422409894 213 dbSNP
rs762721411 221 dbSNP
rs1273231470 225 dbSNP
rs1440339637 226 dbSNP
rs1321185639 236 dbSNP
rs1163710076 241 dbSNP
rs1036886114 249 dbSNP
rs112300032 249 dbSNP
rs2820981 250 dbSNP
rs995557751 251 dbSNP
rs1026904973 276 dbSNP
rs200994093 277 dbSNP
rs117696989 279 dbSNP
rs1054618202 282 dbSNP
rs891511120 291 dbSNP
rs1485190891 301 dbSNP
rs761320410 307 dbSNP
rs575938684 311 dbSNP
rs907351591 312 dbSNP
rs11554567 313 dbSNP
rs537439324 314 dbSNP
rs1366153543 322 dbSNP
rs867680617 323 dbSNP
rs1020476544 334 dbSNP
rs761057260 338 dbSNP
rs1044457 361 dbSNP
rs1322493937 362 dbSNP
rs1288215490 367 dbSNP
rs1466408898 379 dbSNP
rs984773870 394 dbSNP
rs182966385 397 dbSNP
rs1171403647 410 dbSNP
rs925059187 419 dbSNP
rs1015330496 422 dbSNP
rs962190808 423 dbSNP
rs1426152682 424 dbSNP
rs1261719701 432 dbSNP
rs534804633 447 dbSNP
rs990527117 453 dbSNP
rs530211460 456 dbSNP
rs976117420 458 dbSNP
rs553507540 460 dbSNP
rs571912569 462 dbSNP
rs1210552889 470 dbSNP
rs1343161935 484 dbSNP
rs922466390 503 dbSNP
rs879678130 505 dbSNP
rs1276959178 510 dbSNP
rs917803147 519 dbSNP
rs1306981903 531 dbSNP
rs933799044 532 dbSNP
rs985365173 533 dbSNP
rs1294827665 536 dbSNP
rs539301652 544 dbSNP
rs1396500790 545 dbSNP
rs949345313 547 dbSNP
rs1310867005 557 dbSNP
rs1181573079 558 dbSNP
rs868763332 559 dbSNP
rs935675075 574 dbSNP
rs1413877417 576 dbSNP
rs1370790095 578 dbSNP
rs188113417 579 dbSNP
rs891454394 581 dbSNP
rs1460071244 591 dbSNP
rs896997573 596 dbSNP
rs1164818461 612 dbSNP
rs931185079 621 dbSNP
rs771751143 624 dbSNP
rs889894209 625 dbSNP
rs1483585835 626 dbSNP
rs1358913235 631 dbSNP
rs1007281336 632 dbSNP
rs546733194 634 dbSNP
rs1266138700 635 dbSNP
rs1247016889 647 dbSNP
rs1336876017 654 dbSNP
rs907387568 658 dbSNP
rs1232524738 659 dbSNP
rs1350869884 660 dbSNP
rs1309516482 665 dbSNP
rs114542090 666 dbSNP
rs1020424309 674 dbSNP
rs1293621031 678 dbSNP
rs1458937824 683 dbSNP
rs775028074 692 dbSNP
rs1419752663 696 dbSNP
rs754153282 699 dbSNP
rs1035021860 704 dbSNP
rs888068728 705 dbSNP
rs1462856216 708 dbSNP
rs1006880353 710 dbSNP
rs1473152996 713 dbSNP
rs755207436 715 dbSNP
rs1180053978 718 dbSNP
rs1418740712 721 dbSNP
rs1268246439 728 dbSNP
rs1211719048 729 dbSNP
rs779043267 734 dbSNP
rs1000394987 756 dbSNP
rs1447028457 758 dbSNP
rs1303159942 761 dbSNP
rs1212958238 769 dbSNP
rs543379745 772 dbSNP
rs976148582 773 dbSNP
rs1334812411 775 dbSNP
rs1030352002 776 dbSNP
rs955213110 777 dbSNP
rs1380206639 789 dbSNP
rs1454817687 790 dbSNP
rs985227894 796 dbSNP
rs1458256069 800 dbSNP
rs1391403436 809 dbSNP
rs1157201071 824 dbSNP
rs971013830 826 dbSNP
rs752915746 827 dbSNP
rs972623021 838 dbSNP
rs935972744 840 dbSNP
rs1376325197 849 dbSNP
rs918536577 852 dbSNP
rs1286180760 854 dbSNP
rs911280051 854 dbSNP
rs931133236 854 dbSNP
rs561684776 855 dbSNP
rs1256279582 860 dbSNP
rs1240962321 864 dbSNP
rs1286963080 868 dbSNP
rs1041409964 880 dbSNP
rs901175157 899 dbSNP
rs1302087804 901 dbSNP
rs1435113107 909 dbSNP
rs912927222 910 dbSNP
rs1010689148 915 dbSNP
rs1382070179 920 dbSNP
rs945669980 924 dbSNP
rs1045509289 927 dbSNP
rs10198 937 dbSNP
rs906917811 946 dbSNP
rs937065661 951 dbSNP
rs1394644268 954 dbSNP
rs1439774120 956 dbSNP
rs1178369874 961 dbSNP
rs191207375 962 dbSNP
rs541131173 964 dbSNP
rs1243837583 968 dbSNP
rs559539654 981 dbSNP
rs1034532447 991 dbSNP
rs1446256659 992 dbSNP
rs959350762 998 dbSNP
rs1212690661 1006 dbSNP
rs1345305147 1011 dbSNP
rs370728568 1021 dbSNP
rs1012002699 1022 dbSNP
rs1463853315 1044 dbSNP
rs1329640306 1047 dbSNP
rs551724003 1052 dbSNP
rs1268980749 1058 dbSNP
rs1025185315 1064 dbSNP
rs1006500817 1079 dbSNP
rs970410245 1085 dbSNP
rs1447628891 1094 dbSNP
rs1315200362 1097 dbSNP
rs972399563 1098 dbSNP
rs1281305397 1104 dbSNP
rs760271138 1106 dbSNP
rs78590846 1107 dbSNP
rs1302564271 1115 dbSNP
rs1417429736 1117 dbSNP
rs1167369750 1125 dbSNP
rs1326171802 1137 dbSNP
rs1197067550 1144 dbSNP
rs1475054768 1153 dbSNP
rs1257043938 1160 dbSNP
rs1368922398 1175 dbSNP
rs997434602 1176 dbSNP
rs1030383314 1178 dbSNP
rs745854327 1182 dbSNP
rs1205398095 1187 dbSNP
rs911065217 1190 dbSNP
rs1270303320 1191 dbSNP
rs1213418995 1197 dbSNP
rs1357677993 1197 dbSNP
rs1244515828 1206 dbSNP
rs1477395465 1209 dbSNP
rs1191756213 1211 dbSNP
rs1431344315 1213 dbSNP
rs1476721979 1214 dbSNP
rs953499994 1218 dbSNP
rs1355204764 1219 dbSNP
rs145943145 1226 dbSNP
rs780012973 1232 dbSNP
rs1352926532 1236 dbSNP
rs1328284135 1237 dbSNP
rs1331102404 1239 dbSNP
rs1348263898 1247 dbSNP
rs1395209785 1253 dbSNP
rs1166992021 1272 dbSNP
rs1435833631 1289 dbSNP
rs1474131088 1291 dbSNP
rs1294700718 1300 dbSNP
rs1182580218 1301 dbSNP
rs922708813 1305 dbSNP
rs1230754565 1306 dbSNP
rs182786283 1308 dbSNP
rs17103161 1312 dbSNP
rs1275658415 1313 dbSNP
rs749029954 1316 dbSNP
rs1212336739 1323 dbSNP
rs904747348 1328 dbSNP
rs552073989 1335 dbSNP
rs990097428 1336 dbSNP
rs1000460217 1350 dbSNP
rs1371458983 1351 dbSNP
rs913100368 1380 dbSNP
rs1279180134 1388 dbSNP
rs1216011147 1407 dbSNP
rs1437349280 1407 dbSNP
rs967042517 1413 dbSNP
rs1287285583 1418 dbSNP
rs1327891432 1432 dbSNP
rs1055935390 1433 dbSNP
rs1221579632 1435 dbSNP
rs1270980991 1439 dbSNP
rs981138365 1444 dbSNP
rs1405415236 1446 dbSNP
rs1487240575 1447 dbSNP
rs894642888 1448 dbSNP
rs116147582 1453 dbSNP
rs1024711953 1455 dbSNP
rs1191158399 1456 dbSNP
rs138974275 1465 dbSNP
rs1424127618 1469 dbSNP
rs1269241960 1472 dbSNP
rs1369861055 1473 dbSNP
rs1218462280 1474 dbSNP
rs993768353 1476 dbSNP
rs1283883725 1478 dbSNP
rs1220001731 1483 dbSNP
rs1350272949 1484 dbSNP
rs937095087 1488 dbSNP
rs1055935763 1491 dbSNP
rs1476260254 1492 dbSNP
rs1301365989 1493 dbSNP
rs1169929521 1494 dbSNP
rs1440177832 1495 dbSNP
rs571446549 1496 dbSNP
rs1370241740 1497 dbSNP
rs539602870 1509 dbSNP
rs111466903 1518 dbSNP
rs1303782131 1520 dbSNP
rs984005374 1524 dbSNP
rs1158055739 1531 dbSNP
rs576253238 1533 dbSNP
rs1396454240 1549 dbSNP
rs1368033608 1550 dbSNP
rs942167909 1554 dbSNP
rs879484786 1565 dbSNP
rs1188777106 1566 dbSNP
rs922687329 1591 dbSNP
rs1036621116 1594 dbSNP
rs3088062 1601 dbSNP
rs1211982936 1605 dbSNP
rs1486780010 1609 dbSNP
rs997718623 1617 dbSNP
rs925948936 1623 dbSNP
rs1342936528 1633 dbSNP
rs555355359 1645 dbSNP
rs573678683 1646 dbSNP
rs1359723004 1651 dbSNP
rs1288091258 1653 dbSNP
rs1282070491 1667 dbSNP
rs1415096131 1674 dbSNP
rs774212843 1676 dbSNP
rs1056045222 1712 dbSNP
rs1433611827 1721 dbSNP
rs747741314 1723 dbSNP
rs1373119682 1725 dbSNP
rs1171851736 1732 dbSNP
rs569073503 1735 dbSNP
rs1419354512 1741 dbSNP
rs1189175653 1749 dbSNP
rs1293273133 1754 dbSNP
rs1007673597 1757 dbSNP
rs1350823887 1758 dbSNP
rs1210403947 1765 dbSNP
rs1215873063 1768 dbSNP
rs771654473 1778 dbSNP
rs1481061147 1781 dbSNP
rs1046337188 1785 dbSNP
rs1202461161 1789 dbSNP
rs1032813269 1798 dbSNP
rs1294762411 1803 dbSNP
rs957230014 1809 dbSNP
rs1233730870 1810 dbSNP
rs772558703 1821 dbSNP
rs541071605 1827 dbSNP
rs1025223723 1842 dbSNP
rs967327141 1850 dbSNP
rs1299398094 1857 dbSNP
rs1459965581 1866 dbSNP
rs888109388 1872 dbSNP
rs981336486 1881 dbSNP
rs1448590614 1882 dbSNP
rs761267385 1886 dbSNP
rs1416188703 1890 dbSNP
rs1187623165 1893 dbSNP
rs537680955 1898 dbSNP
rs1252849573 1905 dbSNP
rs1472567290 1910 dbSNP
rs1005208080 1912 dbSNP
rs1164413745 1923 dbSNP
rs1257396397 1948 dbSNP
rs139870385 1950 dbSNP
rs187432473 1952 dbSNP
rs577695495 1957 dbSNP
rs1029918721 1964 dbSNP
rs991270625 1984 dbSNP
rs1386224555 1985 dbSNP
rs1402821724 1987 dbSNP
rs1332554727 1990 dbSNP
rs1335984847 1991 dbSNP
rs1389227456 2003 dbSNP
rs1371945901 2011 dbSNP
rs1325947813 2013 dbSNP
rs750978109 2023 dbSNP
rs3835608 2028 dbSNP
rs908917597 2032 dbSNP
rs1164669253 2033 dbSNP
rs1454630292 2046 dbSNP
rs6795 2048 dbSNP
rs1316695822 2057 dbSNP
rs1418617178 2061 dbSNP
rs563743539 2069 dbSNP
rs1195525625 2071 dbSNP
rs1238788243 2080 dbSNP
rs1036974925 2088 dbSNP
rs1250988559 2093 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM545216. RNA binding protein: AGO2. Condition:miR-124 transfection PAR-CLIP data was present in GSM545217. RNA binding protein: AGO2. Condition:miR-7 transfection ...

- Hafner M; Landthaler M; Burger L; Khorshid et al., 2010, Cell.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' gggaguuuuuccuUCGUGAAa 5'
                       ||||||| 
Target 5' ---ucuuauuuucAGCACUUa 3'
 		1 - 18
Article - Hafner M; Landthaler M; Burger L; Khorshid et al.
- Cell, 2010
RNA transcripts are subject to posttranscriptional gene regulation involving hundreds of RNA-binding proteins (RBPs) and microRNA-containing ribonucleoprotein complexes (miRNPs) expressed in a cell-type dependent fashion. We developed a cell-based crosslinking approach to determine at high resolution and transcriptome-wide the binding sites of cellular RBPs and miRNPs. The crosslinked sites are revealed by thymidine to cytidine transitions in the cDNAs prepared from immunopurified RNPs of 4-thiouridine-treated cells. We determined the binding sites and regulatory consequences for several intensely studied RBPs and miRNPs, including PUM2, QKI, IGF2BP1-3, AGO/EIF2C1-4 and TNRC6A-C. Our study revealed that these factors bind thousands of sites containing defined sequence motifs and have distinct preferences for exonic versus intronic or coding versus untranslated transcript regions. The precise mapping of binding sites across the transcriptome will be critical to the interpretation of the rapidly emerging data on genetic variation between individuals and how these variations contribute to complex genetic diseases.
LinkOut: [PMID: 20371350]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Disease 51727.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM714644. RNA binding protein: AGO2. Condition:completeT1 ...

- Kishore S; Jaskiewicz L; Burger L; Hausser et al., 2011, Nature methods.

Article - Kishore S; Jaskiewicz L; Burger L; Hausser et al.
- Nature methods, 2011
Cross-linking and immunoprecipitation (CLIP) is increasingly used to map transcriptome-wide binding sites of RNA-binding proteins. We developed a method for CLIP data analysis, and applied it to compare CLIP with photoactivatable ribonucleoside-enhanced CLIP (PAR-CLIP) and to uncover how differences in cross-linking and ribonuclease digestion affect the identified sites. We found only small differences in accuracies of these methods in identifying binding sites of HuR, which binds low-complexity sequences, and Argonaute 2, which has a complex binding specificity. We found that cross-link-induced mutations led to single-nucleotide resolution for both PAR-CLIP and CLIP. Our results confirm the expectation from original CLIP publications that RNA-binding proteins do not protect their binding sites sufficiently under the denaturing conditions used during the CLIP procedure, and we show that extensive digestion with sequence-specific RNases strongly biases the recovered binding sites. This bias can be substantially reduced by milder nuclease digestion conditions.
LinkOut: [PMID: 21572407]
Experimental Support 3 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Disease 51727.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM1065668. RNA binding protein: AGO1. Condition:4-thiouridine "PAR-CLIP data was present in GSM1065670. RNA binding protein: AGO2. Condition:4-thiouridine ...

- Memczak S; Jens M; Elefsinioti A; Torti F; et al., 2013, Nature.

Article - Memczak S; Jens M; Elefsinioti A; Torti F; et al.
- Nature, 2013
Circular RNAs (circRNAs) in animals are an enigmatic class of RNA with unknown function. To explore circRNAs systematically, we sequenced and computationally analysed human, mouse and nematode RNA. We detected thousands of well-expressed, stable circRNAs, often showing tissue/developmental-stage-specific expression. Sequence analysis indicated important regulatory functions for circRNAs. We found that a human circRNA, antisense to the cerebellar degeneration-related protein 1 transcript (CDR1as), is densely bound by microRNA (miRNA) effector complexes and harbours 63 conserved binding sites for the ancient miRNA miR-7. Further analyses indicated that CDR1as functions to bind miR-7 in neuronal tissues. Human CDR1as expression in zebrafish impaired midbrain development, similar to knocking down miR-7, suggesting that CDR1as is a miRNA antagonist with a miRNA-binding capacity ten times higher than any other known transcript. Together, our data provide evidence that circRNAs form a large class of post-transcriptional regulators. Numerous circRNAs form by head-to-tail splicing of exons, suggesting previously unrecognized regulatory potential of coding sequences.
LinkOut: [PMID: 23446348]
CLIP-seq Support 1 for dataset GSM545216
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / miR-124 transfection
Location of target site ENST00000371873.5 | 3UTR | UUUCUUAUUUUCAGCACUUACAUCAUUUGGUACACAGGGUCAAAUA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 20371350 / GSE21578
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM545217
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / miR-7 transfection
Location of target site ENST00000371873.5 | 3UTR | UCUUAUUUUCAGCACUUACAUCAUUUGGUACACAGGGUCA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 20371350 / GSE21578
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM714644
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / completeT1, repA
Location of target site ENST00000371873.5 | 3UTR | UGUUUCUUAUUUUCAGCACUUACAUCAUUUGGUACACAGGGUCAAAUAGGGCAAAU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 21572407 / GSE28865
CLIP-seq Viewer Link
CLIP-seq Support 4 for dataset GSM1065668
Method / RBP PAR-CLIP / AGO1
Cell line / Condition HEK293 / 4-thiouridine, ML_MM_7
Location of target site ENST00000371873.5 | 3UTR | CACUUACAUCAUUUGGUACACAGGGUCA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23446348 / GSE43573
CLIP-seq Viewer Link
CLIP-seq Support 5 for dataset GSM1065670
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / 4-thiouridine, 3_ML_LG
Location of target site ENST00000371873.5 | 3UTR | UUUCUUAUUUUCAGCACUUACAUCAUUUGGUACACAGGGUCA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23446348 / GSE43573
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE28260 Renal cortex and medulla -0.82 3.0e-4 -0.758 1.3e-3 13 Click to see details
GSE42095 Differentiated embryonic stem cells -0.413 2.5e-2 -0.340 5.6e-2 23 Click to see details
GSE38974 Chronic obstructive pulmonary disease -0.305 6.9e-2 -0.268 9.8e-2 25 Click to see details
GSE35602 Colorectal cancer stromal tissue -0.248 1.2e-1 0.112 3.0e-1 25 Click to see details
GSE32688 Pancreatic cancer -0.187 1.5e-1 -0.235 9.8e-2 32 Click to see details
GSE14794 Lymphoblastoid cells 0.099 1.8e-1 0.165 6.0e-2 90 Click to see details
GSE15076 Monocyte-derived dendritic cells -0.31 2.3e-1 0.042 4.6e-1 8 Click to see details
GSE17498 Multiple myeloma -0.119 2.3e-1 -0.126 2.2e-1 40 Click to see details
GSE26953 Aortic valvular endothelial cells 0.136 2.6e-1 0.296 8.0e-2 24 Click to see details
GSE17306 Multiple myeloma -0.072 3.1e-1 -0.107 2.3e-1 49 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis 0.102 3.3e-1 -0.265 1.3e-1 20 Click to see details
GSE19350 CNS germ cell tumors 0.131 3.4e-1 -0.038 4.5e-1 12 Click to see details
GSE21849 B cell lymphoma 0.074 3.5e-1 0.066 3.7e-1 29 Click to see details
GSE21687 Ependynoma primary tumors -0.04 3.8e-1 -0.030 4.1e-1 64 Click to see details
GSE28544 Breast cancer 0.064 3.8e-1 -0.086 3.4e-1 24 Click to see details
GSE38226 Liver fibrosis 0.059 4.0e-1 0.509 9.2e-3 21 Click to see details
GSE27834 Pluripotent stem cells 0.057 4.2e-1 0.100 3.6e-1 16 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
0.057 4.2e-1 0.100 3.6e-1 16 Click to see details
0.057 4.2e-1 0.100 3.6e-1 16 Click to see details
0.057 4.2e-1 0.100 3.6e-1 16 Click to see details
0.057 4.2e-1 0.100 3.6e-1 16 Click to see details
423 hsa-miR-520e Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT006513 CD46 CD46 molecule 4 1
MIRT007338 PFKP phosphofructokinase, platelet 5 9
MIRT052929 MAP3K14 mitogen-activated protein kinase kinase kinase 14 3 1
MIRT052966 MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 3 1
MIRT057396 TNKS2 tankyrase 2 2 2
MIRT061195 MED17 mediator complex subunit 17 2 2
MIRT061366 WEE1 WEE1 G2 checkpoint kinase 2 2
MIRT063068 ULK1 unc-51 like autophagy activating kinase 1 2 2
MIRT064717 CCND2 cyclin D2 2 2
MIRT065871 GDF11 growth differentiation factor 11 2 2
MIRT066869 TMEM19 transmembrane protein 19 2 2
MIRT067243 FOXJ2 forkhead box J2 2 2
MIRT070853 EIF2S1 eukaryotic translation initiation factor 2 subunit alpha 2 4
MIRT071388 CMPK1 cytidine/uridine monophosphate kinase 1 2 6
MIRT075787 KIAA0513 KIAA0513 2 6
MIRT077844 MINK1 misshapen like kinase 1 2 2
MIRT078824 UNK unkempt family zinc finger 2 2
MIRT079424 FOXK2 forkhead box K2 2 4
MIRT080190 PRKACB protein kinase cAMP-activated catalytic subunit beta 2 2
MIRT083973 RAB22A RAB22A, member RAS oncogene family 2 4
MIRT084955 BACH1 BTB domain and CNC homolog 1 2 2
MIRT093815 KLF3 Kruppel like factor 3 2 2
MIRT093953 SLAIN2 SLAIN motif family member 2 2 2
MIRT108662 ZBTB33 zinc finger and BTB domain containing 33 2 4
MIRT112100 TIMM17A translocase of inner mitochondrial membrane 17A 2 6
MIRT122376 RGMB repulsive guidance molecule family member b 2 4
MIRT124139 GINS4 GINS complex subunit 4 2 4
MIRT130113 TXNIP thioredoxin interacting protein 2 8
MIRT138705 MPP5 membrane palmitoylated protein 5 2 2
MIRT147298 KPNA2 karyopherin subunit alpha 2 2 10
MIRT155916 SIK1 salt inducible kinase 1 2 2
MIRT165910 CREBRF CREB3 regulatory factor 2 2
MIRT173700 PRPF4 pre-mRNA processing factor 4 2 2
MIRT178673 FAM102B family with sequence similarity 102 member B 2 2
MIRT187262 DAZAP2 DAZ associated protein 2 2 10
MIRT199118 ZNF532 zinc finger protein 532 2 2
MIRT199293 SH3GLB1 SH3 domain containing GRB2 like, endophilin B1 2 2
MIRT200934 ZNF264 zinc finger protein 264 2 6
MIRT201032 ZNF805 zinc finger protein 805 2 2
MIRT213215 REST RE1 silencing transcription factor 2 6
MIRT216435 SERF1A small EDRK-rich factor 1A 2 2
MIRT216460 SERF1B small EDRK-rich factor 1B 2 2
MIRT242210 TTC9 tetratricopeptide repeat domain 9 2 4
MIRT242366 IGF1R insulin like growth factor 1 receptor 2 2
MIRT242511 SUZ12 SUZ12 polycomb repressive complex 2 subunit 2 2
MIRT243435 PAK2 p21 (RAC1) activated kinase 2 2 2
MIRT244600 HOOK3 hook microtubule tethering protein 3 2 2
MIRT281001 SPRED1 sprouty related EVH1 domain containing 1 2 2
MIRT302451 CLIP4 CAP-Gly domain containing linker protein family member 4 2 2
MIRT321784 FZD6 frizzled class receptor 6 2 8
MIRT322534 HMBOX1 homeobox containing 1 2 2
MIRT325522 PTPDC1 protein tyrosine phosphatase domain containing 1 2 2
MIRT356941 FEM1C fem-1 homolog C 2 8
MIRT383608 POU2F1 POU class 2 homeobox 1 2 2
MIRT441407 FAM9C family with sequence similarity 9 member C 2 2
MIRT442447 FGF7 fibroblast growth factor 7 2 6
MIRT443074 ABLIM1 actin binding LIM protein 1 2 2
MIRT444420 EMC1 ER membrane protein complex subunit 1 2 2
MIRT446616 HIP1 huntingtin interacting protein 1 2 4
MIRT446807 C5orf30 chromosome 5 open reading frame 30 2 2
MIRT448351 TSR1 TSR1, ribosome maturation factor 2 6
MIRT448743 ITGA2 integrin subunit alpha 2 2 2
MIRT449158 SORCS2 sortilin related VPS10 domain containing receptor 2 2 2
MIRT449251 MICA MHC class I polypeptide-related sequence A 2 2
MIRT450842 IFFO1 intermediate filament family orphan 1 2 2
MIRT450927 CADM2 cell adhesion molecule 2 2 2
MIRT450963 ATAD2 ATPase family, AAA domain containing 2 2 2
MIRT461251 COX10 COX10, heme A:farnesyltransferase cytochrome c oxidase assembly factor 2 6
MIRT463601 ZBTB34 zinc finger and BTB domain containing 34 2 2
MIRT467913 SLC22A23 solute carrier family 22 member 23 2 2
MIRT471996 NR1D2 nuclear receptor subfamily 1 group D member 2 2 2
MIRT473611 MARK2 microtubule affinity regulating kinase 2 2 2
MIRT474724 KIF13A kinesin family member 13A 2 6
MIRT476988 FAM73B mitoguardin 2 2 2
MIRT477098 FAM160B1 family with sequence similarity 160 member B1 2 6
MIRT477269 ERGIC2 ERGIC and golgi 2 2 2
MIRT478732 CSNK1A1 casein kinase 1 alpha 1 2 6
MIRT479996 CAPRIN2 caprin family member 2 2 4
MIRT480660 BSCL2 BSCL2, seipin lipid droplet biogenesis associated 2 2
MIRT480836 BLCAP bladder cancer associated protein 2 10
MIRT481755 APH1A aph-1 homolog A, gamma-secretase subunit 2 2
MIRT484830 ZNFX1 zinc finger NFX1-type containing 1 2 2
MIRT484929 ZFYVE26 zinc finger FYVE-type containing 26 2 4
MIRT485347 MYO1D myosin ID 2 2
MIRT485831 ARID4B AT-rich interaction domain 4B 2 4
MIRT486013 LPAR2 lysophosphatidic acid receptor 2 2 2
MIRT493131 MKNK2 MAP kinase interacting serine/threonine kinase 2 2 6
MIRT494082 DUSP2 dual specificity phosphatase 2 2 4
MIRT496048 MORC1 MORC family CW-type zinc finger 1 2 2
MIRT497456 DDR2 discoidin domain receptor tyrosine kinase 2 2 2
MIRT498047 SNX5 sorting nexin 5 2 6
MIRT500881 SUCO SUN domain containing ossification factor 2 4
MIRT501398 RBBP6 RB binding protein 6, ubiquitin ligase 2 8
MIRT503790 ZNF12 zinc finger protein 12 2 6
MIRT504083 C9orf40 chromosome 9 open reading frame 40 2 6
MIRT504278 PARP1 poly(ADP-ribose) polymerase 1 2 6
MIRT505169 YOD1 YOD1 deubiquitinase 2 4
MIRT505212 UBN2 ubinuclein 2 2 8
MIRT505985 RAB11FIP1 RAB11 family interacting protein 1 2 4
MIRT506266 PDPK1 3-phosphoinositide dependent protein kinase 1 2 2
MIRT506975 HNRNPR heterogeneous nuclear ribonucleoprotein R 2 2
MIRT507216 FZD9 frizzled class receptor 9 2 6
MIRT507422 ELK4 ELK4, ETS transcription factor 2 4
MIRT508560 CEP72 centrosomal protein 72 2 4
MIRT508729 ZNF682 zinc finger protein 682 2 4
MIRT508820 GPR155 G protein-coupled receptor 155 2 2
MIRT509114 BMP8B bone morphogenetic protein 8b 2 6
MIRT509421 MCM7 minichromosome maintenance complex component 7 2 6
MIRT509729 EFCAB11 EF-hand calcium binding domain 11 2 4
MIRT510013 CRISPLD2 cysteine rich secretory protein LCCL domain containing 2 2 4
MIRT510210 ZNF317 zinc finger protein 317 2 4
MIRT511304 KIAA1551 KIAA1551 2 2
MIRT511403 IFNAR2 interferon alpha and beta receptor subunit 2 2 6
MIRT511540 HMGB1 high mobility group box 1 2 6
MIRT512023 DNAJC10 DnaJ heat shock protein family (Hsp40) member C10 2 2
MIRT512967 PPP1R14C protein phosphatase 1 regulatory inhibitor subunit 14C 2 4
MIRT513811 NFIB nuclear factor I B 2 2
MIRT514121 SERF2 small EDRK-rich factor 2 2 2
MIRT514304 FXYD5 FXYD domain containing ion transport regulator 5 2 6
MIRT514466 FANCA Fanconi anemia complementation group A 2 2
MIRT515189 CRCP CGRP receptor component 2 2
MIRT515559 TMEM134 transmembrane protein 134 2 2
MIRT515916 MFAP2 microfibril associated protein 2 2 4
MIRT516044 MED18 mediator complex subunit 18 2 2
MIRT516355 GABPB1 GA binding protein transcription factor beta subunit 1 2 2
MIRT516543 MIXL1 Mix paired-like homeobox 2 2
MIRT516783 PTRF caveolae associated protein 1 2 4
MIRT517004 COX19 COX19, cytochrome c oxidase assembly factor 2 2
MIRT517171 SLC28A1 solute carrier family 28 member 1 2 2
MIRT517244 PRIM1 DNA primase subunit 1 2 4
MIRT518301 ZNF514 zinc finger protein 514 2 4
MIRT518452 KIF6 kinesin family member 6 2 2
MIRT518683 KCNMB1 potassium calcium-activated channel subfamily M regulatory beta subunit 1 2 2
MIRT518788 MED16 mediator complex subunit 16 2 4
MIRT518847 NEK8 NIMA related kinase 8 2 2
MIRT518956 GRK7 G protein-coupled receptor kinase 7 2 2
MIRT519256 PLA2G12A phospholipase A2 group XIIA 2 2
MIRT519416 KCNA7 potassium voltage-gated channel subfamily A member 7 2 4
MIRT519532 TMEM38A transmembrane protein 38A 2 2
MIRT520066 YIPF4 Yip1 domain family member 4 2 2
MIRT520140 WSB1 WD repeat and SOCS box containing 1 2 2
MIRT520294 UBXN2A UBX domain protein 2A 2 2
MIRT520557 TNRC6B trinucleotide repeat containing 6B 2 2
MIRT520818 TAOK1 TAO kinase 1 2 2
MIRT520994 SOCS5 suppressor of cytokine signaling 5 2 2
MIRT521224 SBNO1 strawberry notch homolog 1 2 2
MIRT521533 QSOX1 quiescin sulfhydryl oxidase 1 2 4
MIRT522156 NR2F6 nuclear receptor subfamily 2 group F member 6 2 4
MIRT522206 NR2C2 nuclear receptor subfamily 2 group C member 2 2 6
MIRT522517 MFN1 mitofusin 1 2 2
MIRT522954 IPO9 importin 9 2 2
MIRT523067 HYPK huntingtin interacting protein K 2 2
MIRT523424 GPR157 G protein-coupled receptor 157 2 4
MIRT523555 GIGYF1 GRB10 interacting GYF protein 1 2 6
MIRT523638 FOXK1 forkhead box K1 2 4
MIRT524236 DCTN6 dynactin subunit 6 2 2
MIRT524279 CYCS cytochrome c, somatic 2 2
MIRT524378 CREB1 cAMP responsive element binding protein 1 2 2
MIRT524441 CNKSR3 CNKSR family member 3 2 2
MIRT524758 BCL2L2 BCL2 like 2 2 2
MIRT524967 AGO3 argonaute 3, RISC catalytic component 2 2
MIRT525651 NHSL2 NHS like 2 2 2
MIRT525687 RPRD2 regulation of nuclear pre-mRNA domain containing 2 2 2
MIRT526623 NME6 NME/NM23 nucleoside diphosphate kinase 6 2 2
MIRT527536 DLGAP5 DLG associated protein 5 2 4
MIRT529523 ICMT isoprenylcysteine carboxyl methyltransferase 2 2
MIRT529987 TNFAIP8L1 TNF alpha induced protein 8 like 1 2 4
MIRT530134 HADHB hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit 2 2
MIRT530575 ABHD15 abhydrolase domain containing 15 2 2
MIRT530973 EXO5 exonuclease 5 2 4
MIRT531464 TNFRSF10B TNF receptor superfamily member 10b 2 4
MIRT531763 TXK TXK tyrosine kinase 2 4
MIRT532037 FHDC1 FH2 domain containing 1 2 2
MIRT532932 ZNF385A zinc finger protein 385A 2 2
MIRT534519 SAR1B secretion associated Ras related GTPase 1B 2 2
MIRT534615 RNASEH1 ribonuclease H1 2 4
MIRT534773 RASGEF1A RasGEF domain family member 1A 2 2
MIRT535257 PIGA phosphatidylinositol glycan anchor biosynthesis class A 2 4
MIRT535389 PER1 period circadian clock 1 2 2
MIRT536024 MCUR1 mitochondrial calcium uniporter regulator 1 2 2
MIRT536112 MBNL1 muscleblind like splicing regulator 1 2 4
MIRT536172 MAP1B microtubule associated protein 1B 2 3
MIRT536295 LIMA1 LIM domain and actin binding 1 2 2
MIRT536357 LEFTY1 left-right determination factor 1 2 2
MIRT536425 KREMEN1 kringle containing transmembrane protein 1 2 2
MIRT536548 KCNJ8 potassium voltage-gated channel subfamily J member 8 2 2
MIRT536616 IRF2 interferon regulatory factor 2 2 2
MIRT536630 INO80D INO80 complex subunit D 2 2
MIRT536868 HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 2 2
MIRT536954 HAS3 hyaluronan synthase 3 2 2
MIRT536981 HABP4 hyaluronan binding protein 4 2 4
MIRT537247 GALNT3 polypeptide N-acetylgalactosaminyltransferase 3 2 2
MIRT537434 FBXL7 F-box and leucine rich repeat protein 7 2 2
MIRT537550 ETNK1 ethanolamine kinase 1 2 2
MIRT537745 ELAVL2 ELAV like RNA binding protein 2 2 2
MIRT537960 DPYSL2 dihydropyrimidinase like 2 2 2
MIRT538003 DPP8 dipeptidyl peptidase 8 2 2
MIRT538258 CUL3 cullin 3 2 4
MIRT538513 CLCN3 chloride voltage-gated channel 3 2 2
MIRT538583 CECR2 CECR2, histone acetyl-lysine reader 2 2
MIRT538647 CCSAP centriole, cilia and spindle associated protein 2 2
MIRT538860 BTG1 BTG anti-proliferation factor 1 2 2
MIRT538911 BRI3BP BRI3 binding protein 2 2
MIRT539011 AVL9 AVL9 cell migration associated 2 2
MIRT539058 ATP6V1C1 ATPase H+ transporting V1 subunit C1 2 4
MIRT539102 ARL10 ADP ribosylation factor like GTPase 10 2 2
MIRT539437 ADAT2 adenosine deaminase, tRNA specific 2 2 2
MIRT540262 FAM89A family with sequence similarity 89 member A 2 2
MIRT540376 MASTL microtubule associated serine/threonine kinase like 2 2
MIRT541293 GLO1 glyoxalase I 2 2
MIRT542129 DIS3L DIS3 like exosome 3'-5' exoribonuclease 2 2
MIRT542255 HSPA4L heat shock protein family A (Hsp70) member 4 like 2 2
MIRT546546 SATB2 SATB homeobox 2 2 2
MIRT547480 MBNL3 muscleblind like splicing regulator 3 2 4
MIRT547639 LCLAT1 lysocardiolipin acyltransferase 1 2 4
MIRT547880 HSPA13 heat shock protein family A (Hsp70) member 13 2 2
MIRT548567 DNAJB14 DnaJ heat shock protein family (Hsp40) member B14 2 2
MIRT550865 SNAP47 synaptosome associated protein 47 2 4
MIRT552161 DAD1 defender against cell death 1 2 2
MIRT552191 F2RL3 F2R like thrombin or trypsin receptor 3 2 2
MIRT553584 TMEM100 transmembrane protein 100 2 2
MIRT553680 TFAP4 transcription factor AP-4 2 4
MIRT554438 SAMD8 sterile alpha motif domain containing 8 2 2
MIRT554496 SAMD12 sterile alpha motif domain containing 12 2 2
MIRT554758 RHOC ras homolog family member C 2 2
MIRT555452 POLR3A RNA polymerase III subunit A 2 2
MIRT556536 LIN52 lin-52 DREAM MuvB core complex component 2 2
MIRT557069 HOXB3 homeobox B3 2 2
MIRT557649 GATA6 GATA binding protein 6 2 2
MIRT560236 KLHL21 kelch like family member 21 2 4
MIRT561335 ZBTB18 zinc finger and BTB domain containing 18 2 2
MIRT566274 PRRG4 proline rich and Gla domain 4 2 2
MIRT567080 KBTBD2 kelch repeat and BTB domain containing 2 2 2
MIRT567939 CRK CRK proto-oncogene, adaptor protein 2 2
MIRT567980 COX6B1 cytochrome c oxidase subunit 6B1 2 2
MIRT568167 CCDC6 coiled-coil domain containing 6 2 2
MIRT571711 RPL17-C18orf32 RPL17-C18orf32 readthrough 2 2
MIRT571762 PSD3 pleckstrin and Sec7 domain containing 3 2 2
MIRT572197 C18orf32 chromosome 18 open reading frame 32 2 2
MIRT572664 AGMAT agmatinase 2 4
MIRT573696 RBM12B RNA binding motif protein 12B 2 2
MIRT574574 NR2F2 nuclear receptor subfamily 2 group F member 2 2 2
MIRT574731 HAUS8 HAUS augmin like complex subunit 8 2 2
MIRT575713 Map1b microtubule-associated protein 1B 2 3
MIRT608736 MYH9 myosin heavy chain 9 2 2
MIRT612599 RANGAP1 Ran GTPase activating protein 1 2 2
MIRT614251 WDR53 WD repeat domain 53 2 4
MIRT615164 SPIB Spi-B transcription factor 2 2
MIRT616160 TCEB1 elongin C 2 2
MIRT616799 FEM1A fem-1 homolog A 2 2
MIRT617866 ESR1 estrogen receptor 1 2 2
MIRT619829 POLM DNA polymerase mu 2 4
MIRT620966 TM4SF5 transmembrane 4 L six family member 5 2 2
MIRT625853 SLC35C2 solute carrier family 35 member C2 2 2
MIRT626209 PNRC1 proline rich nuclear receptor coactivator 1 2 4
MIRT626918 HIST1H2BG histone cluster 1 H2B family member g 2 2
MIRT633110 CBX5 chromobox 5 2 2
MIRT634086 APOH apolipoprotein H 2 2
MIRT634943 GTF2H2C GTF2H2 family member C 2 4
MIRT640022 OSTM1 osteopetrosis associated transmembrane protein 1 2 2
MIRT641694 SPCS1 signal peptidase complex subunit 1 2 2
MIRT645203 POLR3F RNA polymerase III subunit F 2 2
MIRT656319 MELK maternal embryonic leucine zipper kinase 2 2
MIRT659545 CHCHD5 coiled-coil-helix-coiled-coil-helix domain containing 5 2 2
MIRT662395 ICA1L islet cell autoantigen 1 like 2 4
MIRT663613 SEC23B Sec23 homolog B, coat complex II component 2 2
MIRT663940 ZNF554 zinc finger protein 554 2 2
MIRT664216 LSM3 LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated 2 2
MIRT664382 CYB5A cytochrome b5 type A 2 2
MIRT673122 MFSD2A major facilitator superfamily domain containing 2A 2 2
MIRT677143 DEGS1 delta 4-desaturase, sphingolipid 1 2 2
MIRT677249 C15orf40 chromosome 15 open reading frame 40 2 2
MIRT678736 SRCAP Snf2 related CREBBP activator protein 2 2
MIRT679721 FBXL2 F-box and leucine rich repeat protein 2 2 2
MIRT680362 GATAD1 GATA zinc finger domain containing 1 2 4
MIRT680689 ZNF785 zinc finger protein 785 2 2
MIRT680767 WDR73 WD repeat domain 73 2 2
MIRT681399 RMND1 required for meiotic nuclear division 1 homolog 2 2
MIRT681693 ABI2 abl interactor 2 2 2
MIRT681829 N4BP2L2 NEDD4 binding protein 2 like 2 2 2
MIRT682320 RAB42 RAB42, member RAS oncogene family 2 2
MIRT683318 C19orf40 Fanconi anemia core complex associated protein 24 1 1
MIRT683388 ESR2 estrogen receptor 2 2 2
MIRT683492 ZNF7 zinc finger protein 7 2 2
MIRT683524 C11orf54 chromosome 11 open reading frame 54 2 2
MIRT683875 OCIAD1 OCIA domain containing 1 2 2
MIRT683948 MYLK3 myosin light chain kinase 3 2 2
MIRT683977 QRFPR pyroglutamylated RFamide peptide receptor 2 2
MIRT684080 TLR7 toll like receptor 7 2 2
MIRT684133 CEP104 centrosomal protein 104 2 2
MIRT684197 MSRB2 methionine sulfoxide reductase B2 2 2
MIRT684358 BCAS4 breast carcinoma amplified sequence 4 2 2
MIRT684492 GPR137B G protein-coupled receptor 137B 2 2
MIRT684574 ORAI2 ORAI calcium release-activated calcium modulator 2 2 2
MIRT684617 GTF2IRD2B GTF2I repeat domain containing 2B 2 2
MIRT684648 PDE4C phosphodiesterase 4C 2 2
MIRT684713 LRRD1 leucine rich repeats and death domain containing 1 2 2
MIRT684742 DNAJB13 DnaJ heat shock protein family (Hsp40) member B13 2 2
MIRT684787 MYO1F myosin IF 2 2
MIRT684919 CD28 CD28 molecule 2 2
MIRT685195 DCTN5 dynactin subunit 5 2 2
MIRT685248 F2RL1 F2R like trypsin receptor 1 2 2
MIRT685316 ASB16 ankyrin repeat and SOCS box containing 16 2 2
MIRT685351 CCL5 C-C motif chemokine ligand 5 2 2
MIRT685519 MSH3 mutS homolog 3 2 2
MIRT685578 KCNK6 potassium two pore domain channel subfamily K member 6 2 2
MIRT685635 C12orf49 chromosome 12 open reading frame 49 2 2
MIRT685660 C11orf1 chromosome 11 open reading frame 1 2 2
MIRT685709 BHMT2 betaine--homocysteine S-methyltransferase 2 2 2
MIRT685742 C12orf65 chromosome 12 open reading frame 65 2 2
MIRT685783 ZNF426 zinc finger protein 426 2 2
MIRT685883 RTN2 reticulon 2 2 2
MIRT685955 PTGIS prostaglandin I2 synthase 2 2
MIRT686106 TNIP3 TNFAIP3 interacting protein 3 2 2
MIRT686156 HS3ST1 heparan sulfate-glucosamine 3-sulfotransferase 1 2 2
MIRT686283 WWC1 WW and C2 domain containing 1 2 2
MIRT686321 VPS53 VPS53, GARP complex subunit 2 2
MIRT686362 USP15 ubiquitin specific peptidase 15 2 2
MIRT686390 UBE2V2 ubiquitin conjugating enzyme E2 V2 2 2
MIRT686444 LINC00598 long intergenic non-protein coding RNA 598 2 2
MIRT686491 TRIOBP TRIO and F-actin binding protein 2 2
MIRT686527 TRAF3IP2 TRAF3 interacting protein 2 2 2
MIRT686582 TMOD3 tropomodulin 3 2 2
MIRT686693 TIMM10 translocase of inner mitochondrial membrane 10 2 2
MIRT686827 SLC7A11 solute carrier family 7 member 11 2 2
MIRT686880 SLC1A5 solute carrier family 1 member 5 2 2
MIRT686914 SGTB small glutamine rich tetratricopeptide repeat containing beta 2 2
MIRT686980 SERINC1 serine incorporator 1 2 2
MIRT687044 RNF115 ring finger protein 115 2 2
MIRT687079 RABGAP1L RAB GTPase activating protein 1 like 2 2
MIRT687254 PDHB pyruvate dehydrogenase E1 beta subunit 2 2
MIRT687596 MANEAL mannosidase endo-alpha like 2 2
MIRT687650 LRIF1 ligand dependent nuclear receptor interacting factor 1 2 2
MIRT687858 ISCA2 iron-sulfur cluster assembly 2 2 2
MIRT687983 GTF2IRD2 GTF2I repeat domain containing 2 2 2
MIRT688123 GEMIN8 gem nuclear organelle associated protein 8 2 2
MIRT688217 FKBP14 FK506 binding protein 14 2 2
MIRT688275 FAM213A family with sequence similarity 213 member A 2 2
MIRT688487 DNAJB4 DnaJ heat shock protein family (Hsp40) member B4 2 2
MIRT688506 DDI2 DNA damage inducible 1 homolog 2 2 2
MIRT688830 CAPZA2 capping actin protein of muscle Z-line alpha subunit 2 2 2
MIRT689174 ZNF665 zinc finger protein 665 2 2
MIRT689799 GTF2H3 general transcription factor IIH subunit 3 2 2
MIRT689844 HIST1H2BJ histone cluster 1 H2B family member j 2 2
MIRT690739 IRAK4 interleukin 1 receptor associated kinase 4 2 2
MIRT690984 ZNF578 zinc finger protein 578 2 2
MIRT691076 NUGGC nuclear GTPase, germinal center associated 2 2
MIRT691333 KIAA1841 KIAA1841 2 2
MIRT691497 FOXRED2 FAD dependent oxidoreductase domain containing 2 2 2
MIRT691578 CCDC125 coiled-coil domain containing 125 2 2
MIRT691614 IPP intracisternal A particle-promoted polypeptide 2 2
MIRT692074 ACOT9 acyl-CoA thioesterase 9 2 2
MIRT692111 CXorf38 chromosome X open reading frame 38 2 4
MIRT692212 NOL9 nucleolar protein 9 2 2
MIRT692320 RFK riboflavin kinase 2 2
MIRT692382 LY6G5B lymphocyte antigen 6 family member G5B 2 2
MIRT692443 METTL8 methyltransferase like 8 2 2
MIRT692478 APEX2 apurinic/apyrimidinic endodeoxyribonuclease 2 2 2
MIRT692546 PARD3 par-3 family cell polarity regulator 2 2
MIRT692607 GDF5OS growth differentiation factor 5 opposite strand 2 2
MIRT692788 SYNPO2L synaptopodin 2 like 2 2
MIRT692819 C1orf50 chromosome 1 open reading frame 50 2 2
MIRT692881 RBM41 RNA binding motif protein 41 2 2
MIRT692991 LGSN lengsin, lens protein with glutamine synthetase domain 2 2
MIRT693140 THEM4 thioesterase superfamily member 4 2 2
MIRT693353 RNF34 ring finger protein 34 2 2
MIRT694113 ZNF446 zinc finger protein 446 2 2
MIRT694197 ZNF347 zinc finger protein 347 2 2
MIRT694663 C14orf119 chromosome 14 open reading frame 119 2 2
MIRT694817 STX4 syntaxin 4 2 2
MIRT694939 ANKS4B ankyrin repeat and sterile alpha motif domain containing 4B 2 2
MIRT695183 SLC25A33 solute carrier family 25 member 33 2 2
MIRT695309 PIGO phosphatidylinositol glycan anchor biosynthesis class O 2 2
MIRT695663 MAN2B2 mannosidase alpha class 2B member 2 2 2
MIRT695836 ABCG8 ATP binding cassette subfamily G member 8 2 2
MIRT695928 ZNF174 zinc finger protein 174 2 2
MIRT695975 EIF2B2 eukaryotic translation initiation factor 2B subunit beta 2 2
MIRT696186 GNB5 G protein subunit beta 5 2 2
MIRT696447 SUGP1 SURP and G-patch domain containing 1 2 2
MIRT696863 UBOX5 U-box domain containing 5 2 2
MIRT696910 C14orf105 coiled-coil domain containing 198 2 2
MIRT697249 ZYG11A zyg-11 family member A, cell cycle regulator 2 2
MIRT697394 ZMAT3 zinc finger matrin-type 3 2 2
MIRT697988 TSPAN6 tetraspanin 6 2 2
MIRT698334 TMEM127 transmembrane protein 127 2 2
MIRT699274 SLC6A4 solute carrier family 6 member 4 2 2
MIRT699321 SLC35F5 solute carrier family 35 member F5 2 4
MIRT699637 SH3BP5 SH3 domain binding protein 5 2 2
MIRT699699 SF3B3 splicing factor 3b subunit 3 2 2
MIRT700048 RPL14 ribosomal protein L14 2 2
MIRT700106 RNF19B ring finger protein 19B 2 2
MIRT701114 PAPD5 poly(A) RNA polymerase D5, non-canonical 2 2
MIRT701298 NUDT3 nudix hydrolase 3 2 2
MIRT701579 MYPN myopalladin 2 2
MIRT702529 KCND3 potassium voltage-gated channel subfamily D member 3 2 2
MIRT703095 GPRIN3 GPRIN family member 3 2 2
MIRT704114 DRAXIN dorsal inhibitory axon guidance protein 2 2
MIRT704149 DNAL1 dynein axonemal light chain 1 2 2
MIRT704201 LDHD lactate dehydrogenase D 2 2
MIRT704466 CPT1A carnitine palmitoyltransferase 1A 2 2
MIRT704767 CDKN2AIPNL CDKN2A interacting protein N-terminal like 2 2
MIRT705088 C4orf29 abhydrolase domain containing 18 2 2
MIRT705353 ATP1B3 ATPase Na+/K+ transporting subunit beta 3 2 2
MIRT706109 ENTPD4 ectonucleoside triphosphate diphosphohydrolase 4 2 2
MIRT706280 SLC35F6 solute carrier family 35 member F6 2 2
MIRT706315 CCDC30 coiled-coil domain containing 30 2 2
MIRT706355 STAC2 SH3 and cysteine rich domain 2 2 2
MIRT706407 HAS2 hyaluronan synthase 2 2 2
MIRT706438 LIAS lipoic acid synthetase 2 2
MIRT706518 MTMR9 myotubularin related protein 9 2 2
MIRT707592 PCNXL2 pecanex homolog 2 2 2
MIRT708374 CDIPT CDP-diacylglycerol--inositol 3-phosphatidyltransferase 2 2
MIRT708452 MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 2 2
MIRT709076 FAHD1 fumarylacetoacetate hydrolase domain containing 1 2 2
MIRT709541 ZBED1 zinc finger BED-type containing 1 2 2
MIRT709623 KBTBD6 kelch repeat and BTB domain containing 6 2 2
MIRT714310 ZNF454 zinc finger protein 454 2 2
MIRT715601 ADAM17 ADAM metallopeptidase domain 17 2 2
MIRT716544 GOLGA2 golgin A2 2 2
MIRT717807 FAM114A1 family with sequence similarity 114 member A1 2 2
MIRT719076 ACOX1 acyl-CoA oxidase 1 2 2
MIRT732364 ZBTB7A zinc finger and BTB domain containing 7A 3 1
MIRT734579 MTDH metadherin 3 0
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-520e Glucose NULL 5793 Quantitative real-time PCR endothelial cells 24394957 2014 down-regulated
miR-520e Cisplatin approved 84093 Microarray CNE cells 22614822 2012 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-520e Paclitaxel 36314 NSC125973 approved sensitive cell line (A2780)
hsa-mir-520e Androstenedione+Anastrozole resistant cell line (MCF-7)

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