miRTarBase - #MIRT071722


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pre-miRNA Information
pre-miRNA hsa-mir-216b   
Genomic Coordinates chr2: 56000714 - 56000795
Description Homo sapiens miR-216b stem-loop
Comment This sequence was identified as a miRNA candidate by Berezikov et al. using RAKE and MPSS techniques .
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-216b-3p
Sequence 49| ACACACUUACCCGUAGAGAUUCUA |72
Evidence Experimental
Experiments Illumina
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 9 2 - 56000739 29233923 MiREDiBase
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1032185572 4 dbSNP
rs1291886633 6 dbSNP
rs1195180466 10 dbSNP
rs761473579 10 dbSNP
rs751204276 12 dbSNP
rs368125248 13 dbSNP
rs755646560 13 dbSNP
rs1307586870 14 dbSNP
rs907200088 16 dbSNP
rs763696104 22 dbSNP
rs762699560 24 dbSNP
Putative Targets

miRNA Expression profile
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Biomarker Information
Biomarker ID Name Type Discovered From Mode Level Source Testing Methods
B5PHM2 miR-216b Safety Biomarker (SAF) Clinical/Experimental Data Expression Increase Plasma MiRNA qPCR analyses
Gene Information
Gene Symbol CCNK   
Synonyms CPR4
Description cyclin K
Transcript NM_001099402   
Expression
Putative miRNA Targets on CCNK
3'UTR of CCNK
(miRNA target sites are highlighted)		 
>CCNK|NM_001099402|3'UTR
   1 CGTGAGCCTTTTTTCCCTCTTTGTTTTTTTAACAAGATTTTCTAATCGACTTGCAGAGTAGTTGAAGTGGGTAAGCAGCA
  81 GGGTACCTTGTATAATGCACGACAGTTGCAGTATGGGAAGAATGGACCGGGCCCCTGGGATAAAATCAGAGTGGTCCTCA
 161 CACCTAGAGGACGGGGACAACCAGCTTTCAGAGTAGCCTCATCAGTGCCCTTGCAGTCTGACTGTGTACACTTGGTTCAG
 241 CTAATGTCTGAGAGTCCTGCACTGGGTTACTTTATACTAGTGAGGACGTTAACCAGCCATATTGGCTCAATAAATAGCTT
 321 CGGTAAGGAGTTAATTTCCTTCTAGAAATCAGTGCCTATTTTTCCTGGAAACTCAATTTTAAATAGTCCAATTCCATCTG
 401 AAGCCAAGCTGTTGTCATTTTCATTCGGTGACATTCTCTCCCATGACACCCAGAAGGGGCAGAAGAACCACATTTTTCAT
 481 TTATAGATGTTTGCATCCTTTGTATTAAAATTATTTTGAAGGGGTTGCCTCATTGGATGGCTTTTTTTTTTTCCTCCAGG
 561 GAGAAGGGGAGAAATGTACTTGGAAATTAATGTATGTTTACATCTCTTTGCAAATTCCTGTACATAGAGATATATTTTTT
 641 AAGTGTGAATGTAACAACATACTGTGAATTCCATCTTGGTTACAAATGAGACTCCTTCAGTCAGTTATCCAAATAAAAGC
 721 AGTTCTGAAACTAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' auCU-UAGAGAUGCCCAUUCACACa 5'
            || || |:| :   |||||||| 
Target 5' gaGATATATTTTT---TAAGTGTGa 3'
 627 - 648 151.00 -9.10
2 
miRNA  3' aucUUAG--AGAUGCC----CA--UUCACACa 5'
             ||||   :|:| |    ||  ||||| | 
Target 5' tctAATCGACTTGCAGAGTAGTTGAAGTGGGt 3'
 41 - 72 115.00 -11.16
3 
miRNA  3' aucUUA--GAGAUG-CCCAUUCACACa 5'
             |:|  | :|:| |  |:| |||| 
Target 5' atcAGTGCCCTTGCAGTCTGACTGTGt 3'
 201 - 227 103.00 -6.60
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN26969691 31 COSMIC
COSN20092891 126 COSMIC
COSN1668767 301 COSMIC
COSN27493679 553 COSMIC
COSN29003495 553 COSMIC
COSN31483697 728 COSMIC
COSN30540808 911 COSMIC
COSN26577358 1021 COSMIC
COSN31483629 1029 COSMIC
COSN22546094 1110 COSMIC
COSN16040017 1588 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs542787565 2 dbSNP
rs753953415 3 dbSNP
rs776794029 9 dbSNP
rs1474413517 12 dbSNP
rs1057500571 13 dbSNP
rs762125168 17 dbSNP
rs559873312 18 dbSNP
rs778926708 19 dbSNP
rs769954154 20 dbSNP
rs894761881 20 dbSNP
rs751539159 22 dbSNP
rs757165035 26 dbSNP
rs1296452847 34 dbSNP
rs750853717 48 dbSNP
rs769407837 49 dbSNP
rs779768159 50 dbSNP
rs1370625652 58 dbSNP
rs993662247 70 dbSNP
rs1440555376 72 dbSNP
rs1466911596 73 dbSNP
rs1160779159 96 dbSNP
rs758744749 97 dbSNP
rs1393677973 99 dbSNP
rs3918125 100 dbSNP
rs539655114 101 dbSNP
rs549815043 102 dbSNP
rs1044490070 116 dbSNP
rs188264130 120 dbSNP
rs1017504356 129 dbSNP
rs1180252884 130 dbSNP
rs964642036 135 dbSNP
rs1252072394 136 dbSNP
rs1203944675 141 dbSNP
rs975369404 147 dbSNP
rs3918126 153 dbSNP
rs1283090599 158 dbSNP
rs1293360456 166 dbSNP
rs1235750906 171 dbSNP
rs1375617623 173 dbSNP
rs565536102 174 dbSNP
rs1033155637 176 dbSNP
rs956299340 177 dbSNP
rs968779718 181 dbSNP
rs977904783 189 dbSNP
rs1360457948 191 dbSNP
rs1173701305 194 dbSNP
rs190948481 198 dbSNP
rs1393164331 208 dbSNP
rs1020668039 216 dbSNP
rs549716119 218 dbSNP
rs1313893103 220 dbSNP
rs1251535859 223 dbSNP
rs938837496 225 dbSNP
rs1479776582 228 dbSNP
rs3918127 229 dbSNP
rs1211655638 231 dbSNP
rs1347839792 234 dbSNP
rs916140110 236 dbSNP
rs3918128 244 dbSNP
rs1317835547 251 dbSNP
rs1306731743 252 dbSNP
rs1221773317 255 dbSNP
rs1356950750 266 dbSNP
rs1313000950 273 dbSNP
rs1458343951 274 dbSNP
rs548853061 275 dbSNP
rs1251486987 277 dbSNP
rs4905841 278 dbSNP
rs1290503086 281 dbSNP
rs910314656 288 dbSNP
rs991454579 289 dbSNP
rs1192271572 292 dbSNP
rs201589535 293 dbSNP
rs993199871 294 dbSNP
rs1188787049 301 dbSNP
rs1485356787 309 dbSNP
rs574365914 311 dbSNP
rs1207479327 313 dbSNP
rs1167869410 315 dbSNP
rs565861187 316 dbSNP
rs1214052218 322 dbSNP
rs867332738 323 dbSNP
rs1293479677 325 dbSNP
rs1047921195 336 dbSNP
rs1352948891 352 dbSNP
rs1333001178 358 dbSNP
rs1382763855 359 dbSNP
rs534472378 368 dbSNP
rs182338033 369 dbSNP
rs1047636450 380 dbSNP
rs1017448985 387 dbSNP
rs964586621 393 dbSNP
rs917116288 410 dbSNP
rs950089872 411 dbSNP
rs1415848626 412 dbSNP
rs1195390353 414 dbSNP
rs1369590163 424 dbSNP
rs1212753794 425 dbSNP
rs768534672 427 dbSNP
rs1261594604 428 dbSNP
rs1227319240 434 dbSNP
rs1318740771 437 dbSNP
rs1022258502 439 dbSNP
rs1212761426 444 dbSNP
rs969107026 451 dbSNP
rs1227474854 459 dbSNP
rs977479499 459 dbSNP
rs1271572362 460 dbSNP
rs1293293479 462 dbSNP
rs1442847585 464 dbSNP
rs924664209 474 dbSNP
rs1324959027 481 dbSNP
rs1461168166 483 dbSNP
rs1388808546 484 dbSNP
rs960172351 485 dbSNP
rs1462520836 487 dbSNP
rs1265819233 491 dbSNP
rs745707450 515 dbSNP
rs916087748 517 dbSNP
rs571182098 522 dbSNP
rs1193375170 524 dbSNP
rs1466886729 535 dbSNP
rs948924349 538 dbSNP
rs1338110289 541 dbSNP
rs1249549661 542 dbSNP
rs1348477937 542 dbSNP
rs200466804 542 dbSNP
rs796274631 542 dbSNP
rs186672115 545 dbSNP
rs891962729 553 dbSNP
rs1329588335 554 dbSNP
rs1248855555 557 dbSNP
rs1474685938 558 dbSNP
rs1193638337 559 dbSNP
rs34625381 559 dbSNP
rs1331072806 581 dbSNP
rs928935552 582 dbSNP
rs771963548 584 dbSNP
rs557306688 585 dbSNP
rs1422249352 590 dbSNP
rs35839257 592 dbSNP
rs1166786014 597 dbSNP
rs1437172359 600 dbSNP
rs1173439499 601 dbSNP
rs1477901220 601 dbSNP
rs375083143 603 dbSNP
rs891343218 605 dbSNP
rs1008582147 610 dbSNP
rs531583077 620 dbSNP
rs1172207090 621 dbSNP
rs1017667341 624 dbSNP
rs1436857316 630 dbSNP
rs964457216 631 dbSNP
rs1212368158 633 dbSNP
rs1485977655 633 dbSNP
rs1411091707 634 dbSNP
rs1279463090 645 dbSNP
rs973117701 652 dbSNP
rs1352496229 653 dbSNP
rs1279923644 656 dbSNP
rs3918129 658 dbSNP
rs369414287 660 dbSNP
rs944445056 664 dbSNP
rs1038834353 666 dbSNP
rs1398032845 671 dbSNP
rs1391659789 691 dbSNP
rs1297572456 697 dbSNP
rs950557714 697 dbSNP
rs1413124534 700 dbSNP
rs1341200763 703 dbSNP
rs775607697 709 dbSNP
rs983215711 715 dbSNP
rs1469346271 716 dbSNP
rs1409262354 722 dbSNP
rs1220488048 728 dbSNP
rs1282509865 734 dbSNP
rs1256727190 737 dbSNP
rs1355863432 737 dbSNP
rs1229124959 742 dbSNP
rs1448652358 742 dbSNP
rs900332613 743 dbSNP
rs1292443180 744 dbSNP
rs1286628817 749 dbSNP
rs917189115 750 dbSNP
rs949987162 754 dbSNP
rs760900498 757 dbSNP
rs1010767061 760 dbSNP
rs1292744173 764 dbSNP
rs1446536690 773 dbSNP
rs34115053 774 dbSNP
rs1347432788 775 dbSNP
rs1445678370 777 dbSNP
rs192558201 778 dbSNP
rs1221962201 779 dbSNP
rs1166570123 781 dbSNP
rs1461637978 785 dbSNP
rs573384662 792 dbSNP
rs1264455095 794 dbSNP
rs936105110 796 dbSNP
rs1054543823 798 dbSNP
rs1179589976 801 dbSNP
rs1031674743 806 dbSNP
rs1489558232 807 dbSNP
rs1242586224 812 dbSNP
rs1192228680 825 dbSNP
rs1463330894 829 dbSNP
rs3918130 830 dbSNP
rs542011060 831 dbSNP
rs1023046313 832 dbSNP
rs970185763 833 dbSNP
rs1226639244 840 dbSNP
rs1051675742 844 dbSNP
rs973554177 860 dbSNP
rs920820647 862 dbSNP
rs1430469507 865 dbSNP
rs1363553896 869 dbSNP
rs1328333241 871 dbSNP
rs1461690249 887 dbSNP
rs1393243068 900 dbSNP
rs891398491 905 dbSNP
rs1415687315 906 dbSNP
rs1417691970 909 dbSNP
rs1157844239 915 dbSNP
rs1361019735 918 dbSNP
rs1401807126 920 dbSNP
rs1420154012 923 dbSNP
rs929576892 927 dbSNP
rs1332225013 935 dbSNP
rs1007539839 936 dbSNP
rs1017304367 943 dbSNP
rs1447578006 945 dbSNP
rs911551772 951 dbSNP
rs900173518 954 dbSNP
rs1194006159 961 dbSNP
rs994422162 974 dbSNP
rs1351947556 980 dbSNP
rs1027368776 984 dbSNP
rs1309264128 985 dbSNP
rs1273803619 987 dbSNP
rs1287226366 988 dbSNP
rs950443122 992 dbSNP
rs1340635774 995 dbSNP
rs1356407146 997 dbSNP
rs370394896 998 dbSNP
rs900283502 1003 dbSNP
rs1024543694 1009 dbSNP
rs1253420762 1012 dbSNP
rs946505407 1013 dbSNP
rs971369515 1014 dbSNP
rs1427795913 1015 dbSNP
rs1043587199 1020 dbSNP
rs3918131 1021 dbSNP
rs1238785380 1022 dbSNP
rs999457091 1026 dbSNP
rs1189766003 1031 dbSNP
rs1481734081 1031 dbSNP
rs1035383193 1034 dbSNP
rs565499815 1034 dbSNP
rs561692501 1035 dbSNP
rs1235493062 1051 dbSNP
rs990119495 1054 dbSNP
rs913335570 1058 dbSNP
rs1311905648 1061 dbSNP
rs764963427 1061 dbSNP
rs1051300829 1062 dbSNP
rs1225172629 1070 dbSNP
rs973501683 1071 dbSNP
rs1421419753 1078 dbSNP
rs912713854 1078 dbSNP
rs1407400966 1080 dbSNP
rs1377215283 1086 dbSNP
rs544608796 1100 dbSNP
rs1313342595 1102 dbSNP
rs1170789932 1103 dbSNP
rs1401581370 1108 dbSNP
rs1415172025 1112 dbSNP
rs1160995415 1115 dbSNP
rs1421154047 1118 dbSNP
rs1336250134 1121 dbSNP
rs1408942109 1122 dbSNP
rs1374897881 1123 dbSNP
rs943004719 1130 dbSNP
rs1040361549 1131 dbSNP
rs563292236 1132 dbSNP
rs1483200554 1133 dbSNP
rs898718320 1135 dbSNP
rs1218349453 1141 dbSNP
rs1287258235 1142 dbSNP
rs1317177273 1142 dbSNP
rs1226044856 1144 dbSNP
rs1356889432 1150 dbSNP
rs3918132 1154 dbSNP
rs1255980552 1161 dbSNP
rs1184273862 1162 dbSNP
rs1290448636 1166 dbSNP
rs1048687471 1172 dbSNP
rs974419716 1173 dbSNP
rs921658036 1174 dbSNP
rs184839167 1182 dbSNP
rs1252520188 1184 dbSNP
rs377760540 1187 dbSNP
rs886213066 1190 dbSNP
rs1423784955 1191 dbSNP
rs1005029152 1198 dbSNP
rs374997897 1200 dbSNP
rs1456140002 1201 dbSNP
rs1024178428 1202 dbSNP
rs558979296 1204 dbSNP
rs1188681618 1205 dbSNP
rs1486360299 1207 dbSNP
rs1267888985 1218 dbSNP
rs971636524 1222 dbSNP
rs528195850 1223 dbSNP
rs1336468657 1224 dbSNP
rs1001337698 1225 dbSNP
rs935202664 1227 dbSNP
rs1056367248 1239 dbSNP
rs1034279250 1240 dbSNP
rs1297559565 1253 dbSNP
rs1382573336 1262 dbSNP
rs551129261 1268 dbSNP
rs1472302214 1270 dbSNP
rs1364273830 1271 dbSNP
rs1441386697 1274 dbSNP
rs1318278539 1299 dbSNP
rs866369148 1306 dbSNP
rs1014184263 1307 dbSNP
rs1163937581 1308 dbSNP
rs1196651586 1310 dbSNP
rs1367239567 1313 dbSNP
rs1173248628 1318 dbSNP
rs1376943205 1330 dbSNP
rs1478332224 1335 dbSNP
rs1429617657 1340 dbSNP
rs1247851501 1345 dbSNP
rs188485709 1351 dbSNP
rs1469563264 1359 dbSNP
rs1398262898 1361 dbSNP
rs1465270470 1362 dbSNP
rs1057634 1364 dbSNP
rs905920730 1375 dbSNP
rs750045787 1379 dbSNP
rs1353560068 1383 dbSNP
rs994923633 1394 dbSNP
rs1385392859 1395 dbSNP
rs1341341295 1397 dbSNP
rs1301018830 1407 dbSNP
rs868825134 1410 dbSNP
rs750904592 1412 dbSNP
rs537328724 1419 dbSNP
rs1373496591 1422 dbSNP
rs1324381662 1427 dbSNP
rs1406204213 1429 dbSNP
rs550645350 1434 dbSNP
rs1019181644 1438 dbSNP
rs1315572404 1439 dbSNP
rs1197621843 1448 dbSNP
rs1455815668 1451 dbSNP
rs966302321 1456 dbSNP
rs1197804860 1457 dbSNP
rs1449497683 1459 dbSNP
rs1481419808 1460 dbSNP
rs369431524 1474 dbSNP
rs766723021 1479 dbSNP
rs921605562 1484 dbSNP
rs193144553 1486 dbSNP
rs1452085418 1488 dbSNP
rs1348516208 1494 dbSNP
rs536211359 1508 dbSNP
rs1329528579 1513 dbSNP
rs1421563965 1514 dbSNP
rs923712039 1518 dbSNP
rs796414757 1519 dbSNP
rs1306643989 1524 dbSNP
rs1056717546 1525 dbSNP
rs1403431379 1527 dbSNP
rs917791940 1528 dbSNP
rs1365142680 1530 dbSNP
rs373138565 1533 dbSNP
rs1293255913 1534 dbSNP
rs1213007672 1536 dbSNP
rs1391969690 1537 dbSNP
rs911650299 1544 dbSNP
rs1198471681 1545 dbSNP
rs1389005608 1546 dbSNP
rs905870054 1548 dbSNP
rs1229086217 1550 dbSNP
rs995269018 1551 dbSNP
rs1286521860 1556 dbSNP
rs1417219386 1559 dbSNP
rs1341565449 1565 dbSNP
rs1333961489 1573 dbSNP
rs1413076303 1579 dbSNP
rs1386701826 1584 dbSNP
rs1159357091 1588 dbSNP
rs1456366682 1592 dbSNP
rs1409191259 1595 dbSNP
rs1049131625 1598 dbSNP
rs1217427029 1602 dbSNP
rs1278286101 1603 dbSNP
rs1308843113 1608 dbSNP
rs1185156300 1610 dbSNP
rs184938586 1617 dbSNP
rs886534985 1618 dbSNP
rs1209663769 1619 dbSNP
rs1005029921 1620 dbSNP
rs1264604832 1625 dbSNP
rs1019126987 1626 dbSNP
rs966250375 1629 dbSNP
rs3918133 1635 dbSNP
rs1321616811 1639 dbSNP
rs1260861307 1640 dbSNP
rs1433955237 1644 dbSNP
rs1029289911 1647 dbSNP
rs1295048905 1647 dbSNP
rs1370529484 1647 dbSNP
rs1385937190 1647 dbSNP
rs1476346277 1647 dbSNP
rs376791507 1647 dbSNP
rs967723154 1647 dbSNP
rs1248469677 1648 dbSNP
rs189880485 1650 dbSNP
rs979538576 1652 dbSNP
rs1223884003 1657 dbSNP
rs1030724791 1659 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Disease 8812.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM714644. RNA binding protein: AGO2. Condition:completeT1 ...

- Kishore S; Jaskiewicz L; Burger L; Hausser et al., 2011, Nature methods.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' aucuuagagaugcccaUUCACACa 5'
                          ||||||| 
Target 5' ----------------AAGUGUGa 3'
 		1 - 8
Article - Kishore S; Jaskiewicz L; Burger L; Hausser et al.
- Nature methods, 2011
Cross-linking and immunoprecipitation (CLIP) is increasingly used to map transcriptome-wide binding sites of RNA-binding proteins. We developed a method for CLIP data analysis, and applied it to compare CLIP with photoactivatable ribonucleoside-enhanced CLIP (PAR-CLIP) and to uncover how differences in cross-linking and ribonuclease digestion affect the identified sites. We found only small differences in accuracies of these methods in identifying binding sites of HuR, which binds low-complexity sequences, and Argonaute 2, which has a complex binding specificity. We found that cross-link-induced mutations led to single-nucleotide resolution for both PAR-CLIP and CLIP. Our results confirm the expectation from original CLIP publications that RNA-binding proteins do not protect their binding sites sufficiently under the denaturing conditions used during the CLIP procedure, and we show that extensive digestion with sequence-specific RNases strongly biases the recovered binding sites. This bias can be substantially reduced by milder nuclease digestion conditions.
LinkOut: [PMID: 21572407]
CLIP-seq Support 1 for dataset GSM714644
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / completeT1, repA
Location of target site ENST00000389879.5 | 3UTR | AAGUGUGAAUGUAACAACAUACUGUGAAUUCCAUCUUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 21572407 / GSE28865
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
111 hsa-miR-216b-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT071722 CCNK cyclin K 2 2
MIRT074768 CNEP1R1 CTD nuclear envelope phosphatase 1 regulatory subunit 1 2 2
MIRT101407 SSR1 signal sequence receptor subunit 1 2 2
MIRT241289 AASDHPPT aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 2 4
MIRT268292 CCND1 cyclin D1 2 8
MIRT445347 IFNA6 interferon alpha 6 2 2
MIRT446663 MXI1 MAX interactor 1, dimerization protein 2 4
MIRT447595 MSH3 mutS homolog 3 2 2
MIRT448485 SEMA4F ssemaphorin 4F 2 2
MIRT450309 DRAXIN dorsal inhibitory axon guidance protein 2 2
MIRT451850 TXNDC5 thioredoxin domain containing 5 2 2
MIRT483613 SMC5 structural maintenance of chromosomes 5 2 2
MIRT485633 EEPD1 endonuclease/exonuclease/phosphatase family domain containing 1 2 2
MIRT499766 CIRH1A UTP4, small subunit processome component 2 6
MIRT503337 MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 2 2
MIRT513007 MAN1A2 mannosidase alpha class 1A member 2 2 2
MIRT513529 RHOQ ras homolog family member Q 2 4
MIRT521499 RAB11B RAB11B, member RAS oncogene family 2 2
MIRT524335 CRK CRK proto-oncogene, adaptor protein 2 4
MIRT524731 BRI3BP BRI3 binding protein 2 8
MIRT525326 SNX29 sorting nexin 29 2 2
MIRT526264 CCDC169 coiled-coil domain containing 169 2 2
MIRT527428 NRL neural retina leucine zipper 2 2
MIRT527512 ZNF134 zinc finger protein 134 2 2
MIRT528881 ATF3 activating transcription factor 3 2 2
MIRT529578 IGBP1 immunoglobulin binding protein 1 2 4
MIRT531122 ZYG11B zyg-11 family member B, cell cycle regulator 2 2
MIRT531341 TGIF2LX TGFB induced factor homeobox 2 like, X-linked 2 2
MIRT532433 DHX33 DEAH-box helicase 33 2 2
MIRT534032 STX7 syntaxin 7 2 2
MIRT534538 SACS sacsin molecular chaperone 2 4
MIRT538886 BRWD3 bromodomain and WD repeat domain containing 3 2 2
MIRT539628 CD19 CD19 molecule 2 8
MIRT540327 ATAT1 alpha tubulin acetyltransferase 1 2 8
MIRT540353 OCLN occludin 2 6
MIRT540699 ATG10 autophagy related 10 2 4
MIRT541033 STRBP spermatid perinuclear RNA binding protein 2 8
MIRT541945 NBPF10 NBPF member 10 2 4
MIRT543505 PLS1 plastin 1 2 2
MIRT551164 UBTF upstream binding transcription factor, RNA polymerase I 2 4
MIRT551790 ZNF117 zinc finger protein 117 2 4
MIRT553227 TWF1 twinfilin actin binding protein 1 2 2
MIRT559622 AKIRIN2 akirin 2 2 2
MIRT559719 ADORA2B adenosine A2b receptor 2 2
MIRT564600 ZNF781 zinc finger protein 781 2 2
MIRT567015 KLHL15 kelch like family member 15 2 2
MIRT569564 C7orf26 chromosome 7 open reading frame 26 2 2
MIRT572155 DDX3X DEAD-box helicase 3, X-linked 2 2
MIRT575399 Zdhhc22 zinc finger, DHHC-type containing 22 2 5
MIRT607322 PKNOX1 PBX/knotted 1 homeobox 1 2 4
MIRT607953 NFAM1 NFAT activating protein with ITAM motif 1 2 10
MIRT607979 ZDHHC22 zinc finger DHHC-type containing 22 2 7
MIRT609145 ZNF610 zinc finger protein 610 2 4
MIRT609206 GOSR2 golgi SNAP receptor complex member 2 2 4
MIRT609338 HRASLS5 HRAS like suppressor family member 5 2 2
MIRT609725 KIF5C kinesin family member 5C 2 4
MIRT610014 MED24 mediator complex subunit 24 2 4
MIRT610407 TMEM245 transmembrane protein 245 2 2
MIRT610559 NBPF14 NBPF member 14 2 2
MIRT611291 PAGR1 PAXIP1 associated glutamate rich protein 1 2 2
MIRT611399 ATP9A ATPase phospholipid transporting 9A (putative) 2 2
MIRT611432 C11orf45 chromosome 11 open reading frame 45 2 4
MIRT611710 SLFN13 schlafen family member 13 2 2
MIRT611721 ANK3 ankyrin 3 2 2
MIRT611830 CACNG8 calcium voltage-gated channel auxiliary subunit gamma 8 2 4
MIRT611977 ZNF175 zinc finger protein 175 2 2
MIRT612073 CEP135 centrosomal protein 135 2 4
MIRT612195 CCDC77 coiled-coil domain containing 77 2 2
MIRT612320 UBE2H ubiquitin conjugating enzyme E2 H 2 2
MIRT612354 TNRC6C trinucleotide repeat containing 6C 2 4
MIRT612635 PTEN phosphatase and tensin homolog 2 2
MIRT612773 MLXIP MLX interacting protein 2 4
MIRT612788 MAP3K9 mitogen-activated protein kinase kinase kinase 9 2 4
MIRT612853 JAZF1 JAZF zinc finger 1 2 2
MIRT612965 GID4 GID complex subunit 4 homolog 2 6
MIRT613132 DUSP6 dual specificity phosphatase 6 2 2
MIRT613388 AAK1 AP2 associated kinase 1 2 2
MIRT615058 CRY2 cryptochrome circadian clock 2 2 4
MIRT616046 HSPA12B heat shock protein family A (Hsp70) member 12B 2 2
MIRT617962 SEPT9 septin 9 2 2
MIRT618413 ATP2A2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 2 2
MIRT622448 RNF213 ring finger protein 213 2 2
MIRT623611 IPCEF1 interaction protein for cytohesin exchange factors 1 2 2
MIRT625709 SHROOM1 shroom family member 1 2 2
MIRT630646 ELK1 ELK1, ETS transcription factor 2 2
MIRT630970 KIAA2022 neurite extension and migration factor 2 2
MIRT631003 SPAG7 sperm associated antigen 7 2 2
MIRT640385 EMC1 ER membrane protein complex subunit 1 2 4
MIRT641064 WBSCR17 polypeptide N-acetylgalactosaminyltransferase 17 2 2
MIRT641780 ZDHHC7 zinc finger DHHC-type containing 7 2 4
MIRT646310 MPHOSPH8 M-phase phosphoprotein 8 2 2
MIRT646624 CENPL centromere protein L 2 2
MIRT659653 CDH2 cadherin 2 2 2
MIRT666161 SP1 Sp1 transcription factor 2 2
MIRT667638 LHFPL2 LHFPL tetraspan subfamily member 2 2 2
MIRT668988 CHRFAM7A CHRNA7 (exons 5-10) and FAM7A (exons A-E) fusion 2 2
MIRT680949 PLCXD1 phosphatidylinositol specific phospholipase C X domain containing 1 2 2
MIRT695238 PBK PDZ binding kinase 2 2
MIRT700036 RPL22 ribosomal protein L22 2 2
MIRT707685 GPR50 G protein-coupled receptor 50 2 2
MIRT709324 HMBOX1 homeobox containing 1 2 2
MIRT710176 MTRF1L mitochondrial translational release factor 1 like 2 2
MIRT712007 F9 coagulation factor IX 2 2
MIRT714219 C10orf71 chromosome 10 open reading frame 71 2 2
MIRT714496 HSPA4 heat shock protein family A (Hsp70) member 4 2 2
MIRT714575 GALNT10 polypeptide N-acetylgalactosaminyltransferase 10 2 2
MIRT715982 TFRC transferrin receptor 2 2
MIRT717870 TRAPPC3L trafficking protein particle complex 3 like 2 2
MIRT718289 MINA ribosomal oxygenase 2 2 2
MIRT725200 PTRF caveolae associated protein 1 2 2
MIRT737338 TPX2 TPX2, microtubule nucleation factor 3 0
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-216b Perfluorooctane sulfonate NULL 74483 Microarray zebrafish embryos 20878907 2011 up-regulated
miR-216b 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) NULL 15625 Microarray embryos 22921993 2012 up-regulated
miR-216b Reversine NULL 210332 Microarray C2C12 myoblast cells 24513286 2014 up-regulated
miR-216b Hydroxycamptothecin (HCPT) NULL 97226 Microarray human Tenon's fibroblasts (HTFs) 24681041 2014 down-regulated
miR-216b Hydroxycamptothecin (HCPT) NULL 97226 Quantitative real-time PCR human Tenon's fibroblasts (HTFs) 24681041 2014 down-regulated
miR-216b Curcumin NULL 969516 Quantitative real-time PCR Y79 RB cells. 22510010 2012 down-regulated
miR-216b Doxorubicin approved 31703 Quantitative real-time PCR heart 22859947 2012 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-216b Paclitaxel 36314 NSC125973 approved sensitive cell line (A2780)
hsa-mir-216b Cisplatin 5460033 NSC119875 approved sensitive cell line (A2780)
hsa-miR-216b-3p Tripterygium wilfordii Hook F resistant tissue
hsa-miR-216b-3p Gefitinib 123631 NSC715055 approved sensitive cell line (HCC827)
hsa-miR-216b-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (MGC-803)

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