miRTarBase - #MIRT074502


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pre-miRNA Information
pre-miRNA hsa-mir-16-2   
Genomic Coordinates chr3: 160404745 - 160404825
Description Homo sapiens miR-16-2 stem-loop
Comment This entry represents a second putative hairpin precursor sequence for miR-16, located on chromosome 3 (see also MIR:MI0000070). The sequence was previously named mir-16-3 here and in references .
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-16-2-3p
Sequence 53| CCAAUAUUACUGUGCUGCUUUA |74
Evidence Experimental
Experiments Cloned
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSN30477465 2 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs746992239 2 dbSNP
rs775368833 4 dbSNP
rs373202341 10 dbSNP
rs768780684 13 dbSNP
rs1341798864 22 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol NFATC2IP   
Synonyms ESC2, NIP45, RAD60
Description nuclear factor of activated T-cells 2 interacting protein
Transcript NM_032815   
Expression
Putative miRNA Targets on NFATC2IP
3'UTR of NFATC2IP
(miRNA target sites are highlighted)		 
>NFATC2IP|NM_032815|3'UTR
   1 CACCCCACTCCCTGTTTGACGGCCCAGCCTGGACTTGGGGAGAATGACTTTCCCTTTTTTGCCCCATAAGGGCTAGCATA
  81 AGCTGAGGTAGAACTTATCTTTAAGCTGCAGCAAAATCAAGGAGTGACTTTTGTCCCCTCTCCTGTTGACCCTGGTTTAG
 161 AGCCGTTAACCACTTGGTGAGTTATGTGGGTGTTGTTGCCCTGGGTGGCCTGTGGCTCCGTCCACAAGTCATGCTGAGTT
 241 TTGCAGCCTCTGTGACTTGGAGATGTCCCTTCACCCCTCCCCTTTCACCACCATCCTCTTTTCCTCATGGAAATGTCTGC
 321 TTTATGAAACTATGCACATATTGAAAGTGAGTTGAAACAAATGAGGGTTGGGTAGGAGCTTCCAGGCCTGGGATTTACAC
 401 CACGCCTAGCCCAGCAGAGGCCTTAGTCCCATTTGGGGCTTGGGAGTGACATTTGCTTGAGGCTTATACACTGGTGTGGT
 481 TGCCTGGCTTGCAGGAAATGACCAAGCTCACACATGCTGGCTGAAGCGTAAGCAGACAACTGAGGTACTCTTTTGAAGGA
 561 TGAAGGTGGTGGATTCTCAGCCCTGGGGGTCTTCCTCACCTGAGGACCCTTCAGAGCCACCCTTTCTAGTTTGCATTTCC
 641 TGGTGCACACATTTAAGGCATAACAGCACATTCATCCCTTTGGTTTGGGATCTCAGGAATACAGTCCCATGCAAAGATTC
 721 TCTGGTTTTATGGCTTTTTTCCCTTTCTTTACACCATCCTCTCCCATAAGCACCCATGTCTTTGAATATGAATGTATTTG
 801 TAAAATACCACGTTTCATGTGTGAATATGTGCTTTTACTGTACATAGTGCTATTGTGCAATAGGTCTTATGCTGTTTTCA
 881 CTCAATGTGTGCTAAGATCTAGCCCCATTGACTCTTCTAGAAATGCAGTATTGCTTTGACCTGCCATGTGGCACTCCACA
 961 ATGTCAATTGCAGTTTACACACATTGCCTAAAGTGGGGGACACCTGGGTGCCCCTGACCCCTTGGCACCGGATACAGGCC
1041 ACGATAAACATCCTTTCGTGTGTTCCCTTCTGTGCTTGTGTGGCATGTGTACCCAGGATGGGCCTATAGGTCACAGAGGT
1121 CAGTTTCTCTTTGGTTTTCCAGATTTTCTTTAGAACGGTGACTGACCCTCCTACTTGAGGCCGCCCTTTTCTCCTTATCC
1201 TTGCCAGCACTTGTATTGCCAGACTACCTAATTTTTGCCAGTCTCATGGGTAGATAGTGGTGCAGTGCTTTAACATACAT
1281 TCATCTGATCAGCATTAATTTGGGGAATTTTTTCACTTAGCCTTTCTGGTTTCCCTTCCTGTGCATTGCCCATTTTCTCA
1361 TGGAGTTTCTTATCTTTTTTGGTTTATTCTCAGGAGTTGCTTGTACATTCTTGGGCAATTGCAGATAATTCCAAGAATGC
1441 ATATTTGGGCTGGGTATGGAGGTTCACTGGTAATCCCAGCACTTTGGGAGGCCCAGGCAGAAGGATCGCTGCAGCCCAGG
1521 AGTTCGAGACTAGCCTGGGCAACATAGCGAGACCTCGTCTCTACAAAAAAAAATTAAAAAGGGGGCTTTGGGAGGCCAAG
1601 GCGGGCAGATCATGAGGGCAGGAGATTGAGACCCTCCTGGCCAACATGGTGAAACCCCGTCTCTACTAAAATACAAAAAA
1681 TTAGCTGGGCATGGTGGCGCACACCTGTAGTCCCAGCTACTCTGGAGGCTGAGGCAGGGGAATCGCTTAAACCCAGGAGG
1761 CGGAGATTGCAGTGAGCCAAGGTTCCACCACTGCACTCCAGCCTGGCGACAGAGCAAGGCTCCACTCAAAAAAAAGATTT
1841 AAAGGGGAAAAAATTGAAATTTTCTTTGTATCTAGGGGTATCCGTCACTGAACAGAAATTCTTAATTTTGGCTAGGCGTG
1921 ATGGCTCAGGTCTGTAATCCCAGCACTTTCGGTGGCCGGGGTGGGTGGATCACTTGAGGCCAGGAGTTCAAGACCACCCT
2001 GACCAACTTGGTGAAATCCCATCTCTACTAAAAATACAAAAATTAGCTGGGTGCAGTGGCGCATGCTTGTAATCCCAGCT
2081 ACTCAGGAGGCAGAGGCAGGAGAATCACTTGAACCCGGGAGGTGGAGGCTGCAGTGAACAGAGACAGTGCCACTGCACAT
2161 CAGCCTGAGTGACAGAGAGACTTTGTCTCAAAAAAAAAAGAAAATTTTAATTTTAATGTAGACAGTATGAATTATCTTGT
2241 TCTGCAGTTGGTTGCTTTTTGATTGCTTATTTAATAGAGTTGTTAAGATATTTTACATCTTCTCCTGTTAGCTGTTCAGC
2321 TTTTCCTTTCATATTGAGAACACTACACAGTGCTGAAGTCCAGCTGGTACACACCGGGGTGACACCTTGGCTGCATCTGT
2401 TCTCAACAGTCAGACACTTCTTCTAATTGGTTGATGCTGGGCTGTACTGGTTGCTAAATATTGCACATCATTTTAAAACT
2481 ATTTGAGATGCACTTTTGTACTCAGGAGGCCAAGGCAGGAGGATTGCTTGAGCCCAGGAGTTTGAGACCAGCCTGGGCAA
2561 CACAGCGAGACCTTGTCTCTTAAAAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' auUUCGUCGUG-UCA-----UUAUAACc 5'
            ::|| |:|| :||     ||||||| 
Target 5' ctGGGCTGTACTGGTTGCTAAATATTGc 3'
 2437 - 2464 152.00 -9.80
2 
miRNA  3' auuucGUCGUGUCAUUAUAACc 5'
               :|| |  | |:||||| 
Target 5' tcttcTAGAAATGCAGTATTGc 3'
 913 - 934 133.00 -5.60
3 
miRNA  3' auUUCGU-CGUGUCAUUAUAACc 5'
            || :| ||||    |||||| 
Target 5' gaAACTATGCAC----ATATTGa 3'
 326 - 344 125.00 -5.10
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30162031 21 COSMIC
COSN28845608 23 COSMIC
COSN30518353 86 COSMIC
COSN9645357 109 COSMIC
COSN6083431 128 COSMIC
COSN25244132 1197 COSMIC
COSN22831720 1836 COSMIC
COSN20169760 1873 COSMIC
COSN7303869 2245 COSMIC
COSN24331685 2898 COSMIC
COSN26366314 3133 COSMIC
rs7500321 1837 GWAS
rs1137843 2530 GWAS
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs763727813 5 dbSNP
rs370474345 6 dbSNP
rs377208661 8 dbSNP
rs34270830 10 dbSNP
rs766675472 14 dbSNP
rs752064567 15 dbSNP
rs1232995765 16 dbSNP
rs1301810342 17 dbSNP
rs765181361 21 dbSNP
rs768198449 22 dbSNP
rs1274788926 23 dbSNP
rs539205571 25 dbSNP
rs752948369 33 dbSNP
rs778120474 39 dbSNP
rs1451907097 43 dbSNP
rs749498424 53 dbSNP
rs557911918 55 dbSNP
rs1206824638 60 dbSNP
rs1485600229 66 dbSNP
rs1261481858 67 dbSNP
rs930839301 71 dbSNP
rs1483557185 74 dbSNP
rs1310183294 79 dbSNP
rs752472156 91 dbSNP
rs1234916590 94 dbSNP
rs999492231 95 dbSNP
rs1373021187 99 dbSNP
rs1267345995 103 dbSNP
rs1491003797 109 dbSNP
rs1199497391 115 dbSNP
rs1049124584 121 dbSNP
rs1385084175 126 dbSNP
rs915969837 134 dbSNP
rs1371942983 136 dbSNP
rs1035019544 138 dbSNP
rs186123506 146 dbSNP
rs1173338823 148 dbSNP
rs1435731628 164 dbSNP
rs1012939133 165 dbSNP
rs536911384 166 dbSNP
rs1423743401 180 dbSNP
rs952325958 182 dbSNP
rs555261934 185 dbSNP
rs1367353801 186 dbSNP
rs1188501349 191 dbSNP
rs1484847723 192 dbSNP
rs75797916 193 dbSNP
rs541423235 194 dbSNP
rs543660910 205 dbSNP
rs1272329765 208 dbSNP
rs189258410 213 dbSNP
rs578044564 220 dbSNP
rs1011443259 221 dbSNP
rs1393802034 238 dbSNP
rs1354351459 239 dbSNP
rs1313142895 251 dbSNP
rs112492568 260 dbSNP
rs1377699340 263 dbSNP
rs1428745536 276 dbSNP
rs71387634 278 dbSNP
rs922970799 290 dbSNP
rs1007985199 293 dbSNP
rs551669513 294 dbSNP
rs986480167 296 dbSNP
rs961111184 298 dbSNP
rs972272005 299 dbSNP
rs531152661 303 dbSNP
rs566497518 305 dbSNP
rs750645089 308 dbSNP
rs1486518820 309 dbSNP
rs1248203299 314 dbSNP
rs1026554232 315 dbSNP
rs1340059416 325 dbSNP
rs181968292 341 dbSNP
rs984903757 342 dbSNP
rs751420512 352 dbSNP
rs3206851 359 dbSNP
rs1333549257 360 dbSNP
rs59675198 377 dbSNP
rs185069694 388 dbSNP
rs935458058 402 dbSNP
rs569340242 404 dbSNP
rs528835047 405 dbSNP
rs1459898050 413 dbSNP
rs1417311245 422 dbSNP
rs928622816 423 dbSNP
rs781200367 434 dbSNP
rs934671143 438 dbSNP
rs1361840405 443 dbSNP
rs1053011083 444 dbSNP
rs1056374372 457 dbSNP
rs1252515443 458 dbSNP
rs893029617 465 dbSNP
rs896522266 469 dbSNP
rs1443692442 471 dbSNP
rs1467612418 471 dbSNP
rs1181382646 474 dbSNP
rs11547490 479 dbSNP
rs769374189 493 dbSNP
rs1157874807 504 dbSNP
rs11547489 507 dbSNP
rs1278596931 510 dbSNP
rs1238732999 514 dbSNP
rs1336749985 515 dbSNP
rs889661477 522 dbSNP
rs9922735 529 dbSNP
rs1393828231 544 dbSNP
rs190946406 546 dbSNP
rs1019385402 551 dbSNP
rs1398989181 560 dbSNP
rs1320449937 562 dbSNP
rs1015134679 573 dbSNP
rs926826853 579 dbSNP
rs551202349 580 dbSNP
rs1191663758 585 dbSNP
rs896803612 589 dbSNP
rs961786868 603 dbSNP
rs748788795 617 dbSNP
rs1253560914 621 dbSNP
rs183109867 622 dbSNP
rs1029989100 623 dbSNP
rs1246015016 628 dbSNP
rs1307277188 630 dbSNP
rs953173470 633 dbSNP
rs1260628542 641 dbSNP
rs868569363 644 dbSNP
rs986039341 646 dbSNP
rs1206366280 656 dbSNP
rs952256684 667 dbSNP
rs914475624 674 dbSNP
rs541202289 675 dbSNP
rs1268141211 679 dbSNP
rs768484888 690 dbSNP
rs1438637776 692 dbSNP
rs977223509 693 dbSNP
rs774145488 698 dbSNP
rs1424150176 702 dbSNP
rs536850197 704 dbSNP
rs928763508 705 dbSNP
rs935407213 709 dbSNP
rs1180868544 721 dbSNP
rs1433872973 724 dbSNP
rs1361992526 732 dbSNP
rs1195447159 735 dbSNP
rs1474129636 747 dbSNP
rs1241058426 748 dbSNP
rs1471153998 751 dbSNP
rs1159091231 776 dbSNP
rs879184236 782 dbSNP
rs1056487843 789 dbSNP
rs1448433549 790 dbSNP
rs1209093506 795 dbSNP
rs1277770306 795 dbSNP
rs1347634658 808 dbSNP
rs896462629 810 dbSNP
rs948053661 812 dbSNP
rs934744690 813 dbSNP
rs1337523883 816 dbSNP
rs1269733086 817 dbSNP
rs761108195 819 dbSNP
rs1342534929 821 dbSNP
rs1311327083 824 dbSNP
rs141475470 830 dbSNP
rs888018292 833 dbSNP
rs567211870 837 dbSNP
rs947279862 841 dbSNP
rs1408206298 842 dbSNP
rs1418153400 843 dbSNP
rs1167935409 849 dbSNP
rs534654320 861 dbSNP
rs1408639005 869 dbSNP
rs549139017 871 dbSNP
rs553318889 872 dbSNP
rs186362879 874 dbSNP
rs1041290822 884 dbSNP
rs896881751 886 dbSNP
rs1241720014 887 dbSNP
rs1320124275 888 dbSNP
rs200906440 892 dbSNP
rs993882802 894 dbSNP
rs1232943156 904 dbSNP
rs1030102062 909 dbSNP
rs1439775121 914 dbSNP
rs1353792287 918 dbSNP
rs1329499406 920 dbSNP
rs1322146076 926 dbSNP
rs1415070532 927 dbSNP
rs953034111 933 dbSNP
rs1163749862 934 dbSNP
rs986206706 938 dbSNP
rs545459095 942 dbSNP
rs1021331677 945 dbSNP
rs1023239162 948 dbSNP
rs1483409734 964 dbSNP
rs1195001343 967 dbSNP
rs1479880386 974 dbSNP
rs969023618 985 dbSNP
rs977340567 991 dbSNP
rs1459123304 1004 dbSNP
rs1248085889 1013 dbSNP
rs1247842107 1015 dbSNP
rs924421057 1020 dbSNP
rs1335655427 1021 dbSNP
rs959883965 1030 dbSNP
rs992164293 1031 dbSNP
rs918004135 1036 dbSNP
rs1003014438 1043 dbSNP
rs948198056 1044 dbSNP
rs1448988761 1050 dbSNP
rs752581752 1054 dbSNP
rs1428544850 1056 dbSNP
rs777218986 1058 dbSNP
rs909237930 1059 dbSNP
rs1174422505 1064 dbSNP
rs1379586648 1068 dbSNP
rs1351218177 1076 dbSNP
rs1156522874 1079 dbSNP
rs942245841 1088 dbSNP
rs1417681943 1094 dbSNP
rs191734017 1107 dbSNP
rs1407768333 1108 dbSNP
rs1292252838 1111 dbSNP
rs1442150831 1114 dbSNP
rs988929255 1130 dbSNP
rs759921381 1140 dbSNP
rs1213079301 1143 dbSNP
rs183096748 1149 dbSNP
rs1468991550 1150 dbSNP
rs1267409778 1156 dbSNP
rs1036628486 1157 dbSNP
rs145150742 1158 dbSNP
rs1242064623 1180 dbSNP
rs1368607160 1182 dbSNP
rs1394733047 1183 dbSNP
rs1440940036 1188 dbSNP
rs1393524084 1205 dbSNP
rs765702588 1206 dbSNP
rs1309142767 1214 dbSNP
rs1345476701 1216 dbSNP
rs1051476374 1224 dbSNP
rs1344963053 1225 dbSNP
rs888862175 1227 dbSNP
rs1421912585 1235 dbSNP
rs1393768162 1238 dbSNP
rs1193588676 1240 dbSNP
rs1433808666 1242 dbSNP
rs1269638832 1244 dbSNP
rs1184982192 1247 dbSNP
rs1485631080 1255 dbSNP
rs1242916998 1276 dbSNP
rs1218467691 1279 dbSNP
rs1284712187 1284 dbSNP
rs758231240 1294 dbSNP
rs1226161412 1297 dbSNP
rs1234980666 1303 dbSNP
rs1313437869 1308 dbSNP
rs1292896775 1318 dbSNP
rs1249295744 1319 dbSNP
rs752831814 1320 dbSNP
rs1205669682 1321 dbSNP
rs1402188552 1321 dbSNP
rs1173552886 1322 dbSNP
rs1268059182 1325 dbSNP
rs1021698854 1337 dbSNP
rs1489858882 1341 dbSNP
rs1379891955 1342 dbSNP
rs561513788 1352 dbSNP
rs763016514 1360 dbSNP
rs1269466441 1363 dbSNP
rs918425384 1373 dbSNP
rs929717273 1376 dbSNP
rs998705973 1380 dbSNP
rs1484555055 1389 dbSNP
rs1031552509 1405 dbSNP
rs1243451222 1407 dbSNP
rs1048169530 1408 dbSNP
rs1256613965 1415 dbSNP
rs528760837 1422 dbSNP
rs959833054 1425 dbSNP
rs1200958432 1434 dbSNP
rs888093007 1436 dbSNP
rs992613811 1450 dbSNP
rs1249557362 1451 dbSNP
rs540604253 1455 dbSNP
rs1011942234 1459 dbSNP
rs1045142538 1460 dbSNP
rs1279659854 1463 dbSNP
rs1231140624 1466 dbSNP
rs1169949778 1476 dbSNP
rs1353953677 1486 dbSNP
rs1371601650 1487 dbSNP
rs1312585418 1489 dbSNP
rs1396989694 1501 dbSNP
rs764302878 1509 dbSNP
rs1404921802 1512 dbSNP
rs1431978459 1518 dbSNP
rs1461519454 1519 dbSNP
rs969858496 1526 dbSNP
rs868809146 1527 dbSNP
rs909175741 1534 dbSNP
rs138980034 1538 dbSNP
rs1035855495 1539 dbSNP
rs1425355712 1545 dbSNP
rs1248274003 1549 dbSNP
rs1036574917 1550 dbSNP
rs1457800795 1554 dbSNP
rs751721508 1557 dbSNP
rs1021748606 1558 dbSNP
rs968804825 1563 dbSNP
rs1342678865 1565 dbSNP
rs1480708303 1565 dbSNP
rs919516256 1565 dbSNP
rs1305464580 1569 dbSNP
rs1391381656 1571 dbSNP
rs140645606 1574 dbSNP
rs1333370821 1576 dbSNP
rs911218214 1577 dbSNP
rs965292508 1580 dbSNP
rs1164078526 1588 dbSNP
rs977105939 1593 dbSNP
rs1361894195 1601 dbSNP
rs918415503 1603 dbSNP
rs144679356 1604 dbSNP
rs1228866429 1614 dbSNP
rs1191156361 1619 dbSNP
rs889320011 1623 dbSNP
rs1290839935 1626 dbSNP
rs1007696107 1632 dbSNP
rs1042833439 1634 dbSNP
rs1211319097 1638 dbSNP
rs569420070 1642 dbSNP
rs904158436 1656 dbSNP
rs1488833025 1657 dbSNP
rs1186044705 1659 dbSNP
rs998485212 1660 dbSNP
rs1239881914 1661 dbSNP
rs1451623095 1669 dbSNP
rs1189468930 1675 dbSNP
rs947814067 1682 dbSNP
rs1384930387 1683 dbSNP
rs1031334745 1685 dbSNP
rs1370390427 1690 dbSNP
rs746448064 1691 dbSNP
rs906225186 1691 dbSNP
rs757094679 1697 dbSNP
rs1351028888 1699 dbSNP
rs530557971 1700 dbSNP
rs1286683859 1705 dbSNP
rs891954762 1710 dbSNP
rs1171733831 1712 dbSNP
rs1435278299 1712 dbSNP
rs1010379294 1714 dbSNP
rs548761020 1715 dbSNP
rs1200543978 1717 dbSNP
rs567149281 1722 dbSNP
rs1380236817 1724 dbSNP
rs904565047 1729 dbSNP
rs1216282031 1736 dbSNP
rs578106447 1741 dbSNP
rs1007392204 1743 dbSNP
rs1023206044 1745 dbSNP
rs1344377707 1753 dbSNP
rs553015593 1755 dbSNP
rs780805121 1756 dbSNP
rs1215139952 1758 dbSNP
rs756833149 1762 dbSNP
rs187637539 1763 dbSNP
rs1016349212 1771 dbSNP
rs1310980982 1772 dbSNP
rs1242788473 1773 dbSNP
rs963337408 1783 dbSNP
rs1173759731 1796 dbSNP
rs538666404 1800 dbSNP
rs972049127 1804 dbSNP
rs965801150 1808 dbSNP
rs1193981512 1809 dbSNP
rs1488807303 1810 dbSNP
rs141199395 1814 dbSNP
rs1415157373 1817 dbSNP
rs878900317 1828 dbSNP
rs7500321 1837 dbSNP
rs987756621 1844 dbSNP
rs1277783785 1848 dbSNP
rs1390147708 1848 dbSNP
rs983897234 1849 dbSNP
rs1342136432 1854 dbSNP
rs1310778942 1855 dbSNP
rs910689818 1858 dbSNP
rs909722328 1859 dbSNP
rs1446115668 1860 dbSNP
rs1457329269 1862 dbSNP
rs1170928732 1865 dbSNP
rs1478635246 1865 dbSNP
rs575805600 1871 dbSNP
rs868186182 1876 dbSNP
rs1043166349 1879 dbSNP
rs764825305 1884 dbSNP
rs904274491 1885 dbSNP
rs1238528958 1886 dbSNP
rs934451734 1889 dbSNP
rs1052699913 1891 dbSNP
rs192459527 1895 dbSNP
rs1436142424 1901 dbSNP
rs1014558790 1903 dbSNP
rs1385058753 1904 dbSNP
rs1404091985 1906 dbSNP
rs927632631 1918 dbSNP
rs1284625864 1919 dbSNP
rs1022900267 1931 dbSNP
rs1372360694 1932 dbSNP
rs1320196683 1935 dbSNP
rs1291689959 1948 dbSNP
rs905651516 1951 dbSNP
rs1005390042 1952 dbSNP
rs545412817 1953 dbSNP
rs939042795 1955 dbSNP
rs1290173711 1958 dbSNP
rs376438423 1959 dbSNP
rs963452659 1961 dbSNP
rs892028042 1962 dbSNP
rs1391788244 1963 dbSNP
rs972173324 1977 dbSNP
rs1163688527 1983 dbSNP
rs1405120977 1987 dbSNP
rs573371747 1990 dbSNP
rs1415051248 1993 dbSNP
rs946281547 1995 dbSNP
rs540892366 2004 dbSNP
rs1238116691 2007 dbSNP
rs1179279995 2009 dbSNP
rs756058734 2016 dbSNP
rs954714342 2022 dbSNP
rs1173236179 2028 dbSNP
rs1262719889 2045 dbSNP
rs780130084 2047 dbSNP
rs910813152 2049 dbSNP
rs1212673000 2050 dbSNP
rs1322083970 2052 dbSNP
rs1291841287 2057 dbSNP
rs200213537 2061 dbSNP
rs943652975 2062 dbSNP
rs1480527597 2063 dbSNP
rs565441057 2064 dbSNP
rs201295379 2068 dbSNP
rs1414894833 2075 dbSNP
rs1472613139 2083 dbSNP
rs926147951 2100 dbSNP
rs150731329 2101 dbSNP
rs1175170342 2112 dbSNP
rs934396306 2117 dbSNP
rs901162088 2118 dbSNP
rs1415762420 2129 dbSNP
rs1418277581 2133 dbSNP
rs998114219 2147 dbSNP
rs1159824183 2150 dbSNP
rs370558373 2154 dbSNP
rs895461887 2166 dbSNP
rs1353668430 2170 dbSNP
rs1439784587 2173 dbSNP
rs1190822705 2174 dbSNP
rs1265425033 2174 dbSNP
rs1441594528 2174 dbSNP
rs1025619849 2180 dbSNP
rs1309751299 2181 dbSNP
rs1213341366 2182 dbSNP
rs1248681713 2182 dbSNP
rs544592322 2185 dbSNP
rs1016721509 2190 dbSNP
rs1219319555 2190 dbSNP
rs61680990 2190 dbSNP
rs984011750 2190 dbSNP
rs562988638 2191 dbSNP
rs1369225836 2196 dbSNP
rs969650676 2199 dbSNP
rs1044669284 2205 dbSNP
rs745502874 2210 dbSNP
rs1299330570 2211 dbSNP
rs1422131706 2219 dbSNP
rs537995768 2223 dbSNP
rs1342983180 2235 dbSNP
rs1221091817 2245 dbSNP
rs1279626800 2248 dbSNP
rs1433878162 2251 dbSNP
rs927674056 2252 dbSNP
rs1191840187 2262 dbSNP
rs183534247 2266 dbSNP
rs1263719924 2267 dbSNP
rs939131591 2267 dbSNP
rs1005919333 2278 dbSNP
rs1254582062 2285 dbSNP
rs1038190510 2290 dbSNP
rs74014829 2292 dbSNP
rs993559977 2296 dbSNP
rs1255363378 2297 dbSNP
rs913575738 2301 dbSNP
rs1199344867 2303 dbSNP
rs1026405725 2310 dbSNP
rs557117097 2313 dbSNP
rs796173463 2320 dbSNP
rs1043370131 2326 dbSNP
rs926126262 2335 dbSNP
rs1418413650 2342 dbSNP
rs942894135 2344 dbSNP
rs1170333231 2362 dbSNP
rs187705945 2376 dbSNP
rs1404201394 2377 dbSNP
rs375320956 2380 dbSNP
rs536671024 2387 dbSNP
rs1329364727 2400 dbSNP
rs1361031319 2403 dbSNP
rs571442232 2409 dbSNP
rs998228390 2416 dbSNP
rs1438758461 2417 dbSNP
rs964973686 2419 dbSNP
rs377615052 2424 dbSNP
rs1424622912 2426 dbSNP
rs1195517489 2433 dbSNP
rs1047017440 2434 dbSNP
rs1255345409 2435 dbSNP
rs1361603416 2436 dbSNP
rs778721859 2442 dbSNP
rs868393821 2443 dbSNP
rs143767664 2446 dbSNP
rs775685301 2453 dbSNP
rs1226633630 2462 dbSNP
rs367611984 2466 dbSNP
rs1318096631 2477 dbSNP
rs1259613987 2482 dbSNP
rs1220803665 2492 dbSNP
rs1343324234 2502 dbSNP
rs926093841 2503 dbSNP
rs1017294094 2504 dbSNP
rs1222345808 2505 dbSNP
rs1397194272 2510 dbSNP
rs1381977002 2511 dbSNP
rs1288377278 2513 dbSNP
rs956225348 2523 dbSNP
rs988480362 2527 dbSNP
rs1137843 2530 dbSNP
rs1002421851 2532 dbSNP
rs1199003878 2534 dbSNP
rs1173143100 2536 dbSNP
rs1456176847 2540 dbSNP
rs1188158861 2541 dbSNP
rs1241153660 2541 dbSNP
rs1425412306 2544 dbSNP
rs1236297568 2560 dbSNP
rs1177415015 2565 dbSNP
rs1457845116 2567 dbSNP
rs35988035 2567 dbSNP
rs200429878 2568 dbSNP
rs1190131644 2572 dbSNP
rs1207762374 2580 dbSNP
rs1158011729 2582 dbSNP
rs1265163597 2582 dbSNP
rs1329428145 2582 dbSNP
rs1354687861 2582 dbSNP
rs1378358660 2582 dbSNP
rs1439762076 2582 dbSNP
rs1459265933 2582 dbSNP
rs1390488192 2583 dbSNP
rs1423806755 2584 dbSNP
rs1161569645 2600 dbSNP
rs1392840835 2601 dbSNP
rs1407146231 2602 dbSNP
rs1450628100 2602 dbSNP
rs1284475296 2603 dbSNP
rs1490954797 2603 dbSNP
rs949871349 2603 dbSNP
rs1324344301 2604 dbSNP
rs1044063600 2605 dbSNP
rs1231173824 2606 dbSNP
rs1433085046 2607 dbSNP
rs1300133163 2609 dbSNP
rs1034861306 2614 dbSNP
rs536708567 2615 dbSNP
rs1388261163 2617 dbSNP
rs768994542 2620 dbSNP
rs1358456160 2621 dbSNP
rs960409291 2630 dbSNP
rs1420164152 2634 dbSNP
rs926973930 2636 dbSNP
rs555122367 2638 dbSNP
rs1359157878 2639 dbSNP
rs1038314591 2646 dbSNP
rs1282876339 2647 dbSNP
rs913565678 2651 dbSNP
rs539703466 2652 dbSNP
rs1261561671 2653 dbSNP
rs1216350854 2654 dbSNP
rs1210164910 2672 dbSNP
rs967732116 2673 dbSNP
rs896953827 2677 dbSNP
rs1198758499 2679 dbSNP
rs994012344 2680 dbSNP
rs1050949185 2681 dbSNP
rs1275637185 2702 dbSNP
rs926171140 2709 dbSNP
rs1443747869 2713 dbSNP
rs867316378 2716 dbSNP
rs1370101316 2717 dbSNP
rs1400408823 2718 dbSNP
rs1332161570 2723 dbSNP
rs914111758 2723 dbSNP
rs1413388411 2724 dbSNP
rs1175745735 2725 dbSNP
rs1186107551 2725 dbSNP
rs1205667047 2725 dbSNP
rs1244301480 2725 dbSNP
rs1257701607 2725 dbSNP
rs1279344769 2725 dbSNP
rs1316247196 2725 dbSNP
rs1441915507 2725 dbSNP
rs1459197809 2725 dbSNP
rs1478368722 2725 dbSNP
rs59070168 2725 dbSNP
rs79400818 2725 dbSNP
rs1473052008 2740 dbSNP
rs1189924998 2747 dbSNP
rs1384293618 2748 dbSNP
rs1282346429 2750 dbSNP
rs1455731059 2756 dbSNP
rs890543517 2760 dbSNP
rs534138827 2763 dbSNP
rs1340997932 2768 dbSNP
rs1338059567 2771 dbSNP
rs1463626484 2781 dbSNP
rs922803531 2782 dbSNP
rs1017592826 2789 dbSNP
rs1466446058 2790 dbSNP
rs965085707 2793 dbSNP
rs140531733 2805 dbSNP
rs4788108 2807 dbSNP
rs1033227126 2811 dbSNP
rs1472725618 2814 dbSNP
rs1238583140 2825 dbSNP
rs1185451746 2828 dbSNP
rs4788109 2830 dbSNP
rs1237779085 2831 dbSNP
rs761812459 2832 dbSNP
rs1279522080 2834 dbSNP
rs1287387023 2841 dbSNP
rs577463088 2845 dbSNP
rs4788110 2848 dbSNP
rs1038389762 2850 dbSNP
rs988928236 2851 dbSNP
rs767576376 2852 dbSNP
rs58601202 2853 dbSNP
rs1331591365 2854 dbSNP
rs1443842811 2857 dbSNP
rs1035255905 2858 dbSNP
rs1043818808 2864 dbSNP
rs1460638243 2868 dbSNP
rs960566153 2874 dbSNP
rs1009304721 2875 dbSNP
rs562927084 2876 dbSNP
rs967805616 2878 dbSNP
rs572848148 2881 dbSNP
rs1180935156 2889 dbSNP
rs540211551 2892 dbSNP
rs1409725591 2894 dbSNP
rs1245223239 2897 dbSNP
rs1481706585 2897 dbSNP
rs200185241 2898 dbSNP
rs397691249 2898 dbSNP
rs55964416 2898 dbSNP
rs903959520 2898 dbSNP
rs1309288437 2905 dbSNP
rs1224993820 2910 dbSNP
rs1365007957 2917 dbSNP
rs561560444 2918 dbSNP
rs1436180767 2920 dbSNP
rs1161550695 2922 dbSNP
rs1366644535 2926 dbSNP
rs1412958908 2932 dbSNP
rs1469432020 2937 dbSNP
rs926957188 2946 dbSNP
rs1171045737 2950 dbSNP
rs71389573 2956 dbSNP
rs964611370 2960 dbSNP
rs574917509 2968 dbSNP
rs941028760 2970 dbSNP
rs71389574 2971 dbSNP
rs867373070 2977 dbSNP
rs71389575 2978 dbSNP
rs1038262376 2980 dbSNP
rs918500197 2983 dbSNP
rs1190876922 2998 dbSNP
rs1420988991 2998 dbSNP
rs1423284521 2998 dbSNP
rs71389576 2998 dbSNP
rs1480631025 3015 dbSNP
rs542271149 3018 dbSNP
rs929917896 3025 dbSNP
rs1214198967 3032 dbSNP
rs1328731915 3033 dbSNP
rs144736336 3035 dbSNP
rs773334187 3040 dbSNP
rs528232289 3048 dbSNP
rs71389577 3052 dbSNP
rs1411109155 3057 dbSNP
rs1309982124 3067 dbSNP
rs1300152449 3070 dbSNP
rs1219516437 3080 dbSNP
rs776901154 3084 dbSNP
rs944777886 3085 dbSNP
rs1398563808 3101 dbSNP
rs1230563366 3103 dbSNP
rs1290009347 3105 dbSNP
rs941451204 3114 dbSNP
rs1357554849 3120 dbSNP
rs192320207 3121 dbSNP
rs796776067 3122 dbSNP
rs1470386086 3128 dbSNP
rs1431753318 3132 dbSNP
rs905225277 3136 dbSNP
rs937920657 3140 dbSNP
rs1195051729 3147 dbSNP
rs1056405629 3159 dbSNP
rs78686960 3172 dbSNP
rs1484028571 3175 dbSNP
rs532432550 3181 dbSNP
rs892041917 3182 dbSNP
rs1252550276 3184 dbSNP
rs550909063 3190 dbSNP
rs1432709768 3194 dbSNP
rs1255793362 3215 dbSNP
rs1217149172 3216 dbSNP
rs1340347617 3217 dbSNP
rs775909007 3219 dbSNP
rs1020820261 3220 dbSNP
rs1377627472 3221 dbSNP
rs1302290665 3223 dbSNP
rs763033035 3226 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM545216. RNA binding protein: AGO2. Condition:miR-124 transfection ...

- Hafner M; Landthaler M; Burger L; Khorshid et al., 2010, Cell.

Article - Hafner M; Landthaler M; Burger L; Khorshid et al.
- Cell, 2010
RNA transcripts are subject to posttranscriptional gene regulation involving hundreds of RNA-binding proteins (RBPs) and microRNA-containing ribonucleoprotein complexes (miRNPs) expressed in a cell-type dependent fashion. We developed a cell-based crosslinking approach to determine at high resolution and transcriptome-wide the binding sites of cellular RBPs and miRNPs. The crosslinked sites are revealed by thymidine to cytidine transitions in the cDNAs prepared from immunopurified RNPs of 4-thiouridine-treated cells. We determined the binding sites and regulatory consequences for several intensely studied RBPs and miRNPs, including PUM2, QKI, IGF2BP1-3, AGO/EIF2C1-4 and TNRC6A-C. Our study revealed that these factors bind thousands of sites containing defined sequence motifs and have distinct preferences for exonic versus intronic or coding versus untranslated transcript regions. The precise mapping of binding sites across the transcriptome will be critical to the interpretation of the rapidly emerging data on genetic variation between individuals and how these variations contribute to complex genetic diseases.
LinkOut: [PMID: 20371350]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Disease 84901.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM714644. RNA binding protein: AGO2. Condition:completeT1 ...

- Kishore S; Jaskiewicz L; Burger L; Hausser et al., 2011, Nature methods.

Article - Kishore S; Jaskiewicz L; Burger L; Hausser et al.
- Nature methods, 2011
Cross-linking and immunoprecipitation (CLIP) is increasingly used to map transcriptome-wide binding sites of RNA-binding proteins. We developed a method for CLIP data analysis, and applied it to compare CLIP with photoactivatable ribonucleoside-enhanced CLIP (PAR-CLIP) and to uncover how differences in cross-linking and ribonuclease digestion affect the identified sites. We found only small differences in accuracies of these methods in identifying binding sites of HuR, which binds low-complexity sequences, and Argonaute 2, which has a complex binding specificity. We found that cross-link-induced mutations led to single-nucleotide resolution for both PAR-CLIP and CLIP. Our results confirm the expectation from original CLIP publications that RNA-binding proteins do not protect their binding sites sufficiently under the denaturing conditions used during the CLIP procedure, and we show that extensive digestion with sequence-specific RNases strongly biases the recovered binding sites. This bias can be substantially reduced by milder nuclease digestion conditions.
LinkOut: [PMID: 21572407]
CLIP-seq Support 1 for dataset GSM545216
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / miR-124 transfection
Location of target site ENST00000320805.4 | 3UTR | CUAAAUAUUGCACAUCAUUUUAAAACUAUUUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 20371350 / GSE21578
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM714644
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / completeT1, repA
Location of target site ENST00000320805.4 | 3UTR | CUAAAUAUUGCACAUCAUUUUAAAACUAUUUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 21572407 / GSE28865
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE42095 Differentiated embryonic stem cells 0.678 1.9e-4 0.598 1.3e-3 23 Click to see details
GSE19783 ER- ER- breast cancer 0.322 1.9e-3 0.352 7.3e-4 79 Click to see details
GSE19536 Breast cancer 0.285 2.0e-3 0.322 5.4e-4 100 Click to see details
GSE17498 Multiple myeloma 0.414 4.0e-3 0.384 7.2e-3 40 Click to see details
GSE28544 Breast cancer 0.449 1.4e-2 0.526 4.1e-3 24 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis -0.402 3.9e-2 -0.483 1.5e-2 20 Click to see details
GSE38226 Liver fibrosis -0.365 5.2e-2 -0.206 1.9e-1 21 Click to see details
GSE38974 Chronic obstructive pulmonary disease -0.28 8.8e-2 -0.277 9.0e-2 25 Click to see details
GSE32688 Pancreatic cancer 0.238 9.5e-2 0.185 1.6e-1 32 Click to see details
GSE28260 Renal cortex and medulla 0.323 1.4e-1 0.253 2.0e-1 13 Click to see details
GSE15076 Monocyte-derived dendritic cells 0.21 2.9e-1 0.333 1.9e-1 9 Click to see details
GSE26953 Aortic valvular endothelial cells 0.11 3.0e-1 0.233 1.4e-1 24 Click to see details
GSE21032 Prostate cancer 0.033 3.8e-1 -0.028 4.0e-1 83 Click to see details
GSE35602 Colorectal cancer stromal tissue -0.042 4.2e-1 0.054 4.0e-1 25 Click to see details
GSE19783 ER+ ER+ breast cancer -0.036 4.4e-1 0.165 2.4e-1 20 Click to see details
GSE19350 CNS germ cell tumors -0.023 4.7e-1 0.000 5.0e-1 12 Click to see details
GSE21687 Ependynoma primary tumors -0.002 4.9e-1 -0.050 3.5e-1 64 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
BRCA -0.249 0.01 -0.175 0.06 83 Click to see details
LUAD 0.549 0.03 0.441 0.08 12 Click to see details
LIHC 0.26 0.04 0.289 0.02 49 Click to see details
PAAD 0.927 0.04 0.800 0.1 4 Click to see details
LUSC 0.259 0.06 0.217 0.1 38 Click to see details
STAD 0.201 0.14 0.162 0.19 31 Click to see details
BLCA 0.264 0.14 0.160 0.26 18 Click to see details
HNSC 0.141 0.19 0.166 0.15 42 Click to see details
KIRP 0.147 0.21 0.154 0.2 32 Click to see details
THCA 0.092 0.24 0.048 0.36 59 Click to see details
KIRC 0.085 0.25 0.139 0.13 68 Click to see details
UCEC 0.143 0.28 0.112 0.32 19 Click to see details
KICH 0.12 0.28 0.113 0.3 25 Click to see details
CESC 0.472 0.34 0.500 0.33 3 Click to see details
ESCA 0.087 0.4 0.100 0.38 11 Click to see details
CHOL 0.03 0.47 -0.200 0.3 9 Click to see details
PRAD -0.005 0.49 0.045 0.38 48 Click to see details
PCPG 0.036 0.49 -0.500 0.33 3 Click to see details
PCPG 0.036 0.49 -0.500 0.33 3 Click to see details
PCPG 0.036 0.49 -0.500 0.33 3 Click to see details
75 hsa-miR-16-2-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT004488 RARB retinoic acid receptor beta 3 1
MIRT038707 NUCKS1 nuclear casein kinase and cyclin dependent kinase substrate 1 1 1
MIRT057208 PPIF peptidylprolyl isomerase F 2 4
MIRT058726 RSBN1 round spermatid basic protein 1 2 8
MIRT074502 NFATC2IP nuclear factor of activated T-cells 2 interacting protein 2 4
MIRT081544 ZNF431 zinc finger protein 431 2 4
MIRT096893 ERBB2IP erbb2 interacting protein 2 2
MIRT105124 MYC MYC proto-oncogene, bHLH transcription factor 2 2
MIRT107898 PTAR1 protein prenyltransferase alpha subunit repeat containing 1 2 4
MIRT109432 KLHL15 kelch like family member 15 2 6
MIRT166742 PAPD7 poly(A) RNA polymerase D7, non-canonical 2 6
MIRT171257 YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma 2 2
MIRT192760 B2M beta-2-microglobulin 2 2
MIRT194905 RBBP6 RB binding protein 6, ubiquitin ligase 2 8
MIRT215599 SUB1 SUB1 homolog, transcriptional regulator 2 2
MIRT223632 ATP6V1C1 ATPase H+ transporting V1 subunit C1 2 4
MIRT241605 AMOTL1 angiomotin like 1 2 4
MIRT291174 SH3GLB1 SH3 domain containing GRB2 like, endophilin B1 2 2
MIRT444286 ABCG2 ATP binding cassette subfamily G member 2 (Junior blood group) 2 2
MIRT463285 ZFX zinc finger protein, X-linked 2 4
MIRT471759 NUS1 NUS1 dehydrodolichyl diphosphate synthase subunit 2 8
MIRT479611 CDC25A cell division cycle 25A 2 2
MIRT481497 ARL6IP1 ADP ribosylation factor like GTPase 6 interacting protein 1 2 8
MIRT483117 SH3BP5 SH3 domain binding protein 5 2 2
MIRT502279 GRPEL2 GrpE like 2, mitochondrial 2 8
MIRT507838 CCNT1 cyclin T1 2 2
MIRT508179 MTRNR2L6 MT-RNR2-like 6 2 4
MIRT510576 UBE2D3 ubiquitin conjugating enzyme E2 D3 2 6
MIRT517853 RPS4X ribosomal protein S4, X-linked 2 4
MIRT521690 PRKAA1 protein kinase AMP-activated catalytic subunit alpha 1 2 8
MIRT525070 FRK fyn related Src family tyrosine kinase 2 2
MIRT527082 UBE2E3 ubiquitin conjugating enzyme E2 E3 2 2
MIRT529552 EI24 EI24, autophagy associated transmembrane protein 2 2
MIRT530426 SULT1B1 sulfotransferase family 1B member 1 2 2
MIRT533909 TBC1D15 TBC1 domain family member 15 2 2
MIRT536627 IPO7 importin 7 2 2
MIRT537647 ERGIC2 ERGIC and golgi 2 2 4
MIRT538512 CLCN3 chloride voltage-gated channel 3 2 2
MIRT539219 ANP32E acidic nuclear phosphoprotein 32 family member E 2 6
MIRT539348 AGO2 argonaute 2, RISC catalytic component 2 4
MIRT539954 CCT4 chaperonin containing TCP1 subunit 4 2 2
MIRT541208 HOXA10 homeobox A10 2 2
MIRT543216 TMEM117 transmembrane protein 117 2 2
MIRT543399 DROSHA drosha ribonuclease III 2 2
MIRT546648 RPS6KA5 ribosomal protein S6 kinase A5 2 2
MIRT546852 RAB1A RAB1A, member RAS oncogene family 2 2
MIRT549917 MRPS30 mitochondrial ribosomal protein S30 2 2
MIRT552998 USP46 ubiquitin specific peptidase 46 2 2
MIRT555254 PREPL prolyl endopeptidase-like 2 2
MIRT555956 NRIP1 nuclear receptor interacting protein 1 2 2
MIRT557095 HOXA9 homeobox A9 2 2
MIRT561396 TUBB2A tubulin beta 2A class IIa 2 2
MIRT561654 RNF219 ring finger protein 219 2 2
MIRT563101 PABPC4L poly(A) binding protein cytoplasmic 4 like 2 2
MIRT565979 RNF44 ring finger protein 44 2 2
MIRT572396 CCDC14 coiled-coil domain containing 14 2 2
MIRT574400 TM9SF3 transmembrane 9 superfamily member 3 2 2
MIRT607623 VSNL1 visinin like 1 2 2
MIRT610645 CTGF connective tissue growth factor 2 2
MIRT623379 LPP LIM domain containing preferred translocation partner in lipoma 2 2
MIRT624687 AR androgen receptor 2 2
MIRT632089 ALDH1A2 aldehyde dehydrogenase 1 family member A2 2 2
MIRT644216 CBS cystathionine-beta-synthase 2 2
MIRT647841 BID BH3 interacting domain death agonist 2 2
MIRT651649 WASF2 WAS protein family member 2 2 2
MIRT689064 AGMAT agmatinase 2 2
MIRT698150 TNPO1 transportin 1 2 2
MIRT700516 PTPN14 protein tyrosine phosphatase, non-receptor type 14 2 2
MIRT704081 DYRK2 dual specificity tyrosine phosphorylation regulated kinase 2 2 2
MIRT705970 ACBD5 acyl-CoA binding domain containing 5 2 2
MIRT715694 COMMD3-BMI1 COMMD3-BMI1 readthrough 2 2
MIRT717184 BMI1 BMI1 proto-oncogene, polycomb ring finger 2 2
MIRT724607 AP3B1 adaptor related protein complex 3 beta 1 subunit 2 2
MIRT724854 IGFBP5 insulin like growth factor binding protein 5 2 2
MIRT725401 LRIG2 leucine rich repeats and immunoglobulin like domains 2 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-16-2 Diethylstilbestrol approved 448537 Microarray mammosphere-derived epithelial cells (MDEC) 19549897 2009 down-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-16-2-3p Oxaliplatin 6857599 NSC266046 approved resistant High Colorectal Cancer cell line (HCT-116)
hsa-miR-16-2-3p Mitoxantrone 4212 NSC279836 approved sensitive High Breast Cancer cell line (MCF-7)
hsa-miR-16-2-3p Cisplatin 5460033 NSC119875 approved sensitive Low Osteosarcoma cell line (HOS)
hsa-miR-16-2-3p Doxorubicin 31703 NSC123127 approved sensitive Low Osteosarcoma cell line (HOS)
hsa-miR-16-2-3p Paclitaxel 36314 NSC125973 approved sensitive High Non-Small Cell Lung Cancer cell line (H460)
hsa-miR-16-2-3p Bortezomib 387447 NSC681239 approved resistant Low Multiple Myeloma tissue
hsa-miR-16-2-3p Gefitinib 123631 NSC715055 approved sensitive cell line (HCC827)
hsa-miR-16-2-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (CAL-27) (cytosolic RNA)
hsa-miR-16-2-3p Cisplatin 5460033 NSC119875 approved resistant cell line (CAL-27) (total RNA)
hsa-miR-16-2-3p Vemurafenib 42611257 NSC761431 approved sensitive cell line (451Lu)
hsa-miR-16-2-3p Doxorubicin 31703 NSC123127 approved sensitive cell line (BAS)
hsa-miR-16-2-3p Osimertinib 71496458 NSC779217 approved sensitive cell line (H1975)
hsa-miR-16-2-3p Sunitinib 5329102 NSC750690 approved resistant tissue (CardB)
hsa-miR-16-2-3p Cisplatin 5460033 NSC119875 approved resistant cell line (HCT8)
hsa-miR-16-2-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (IGROV-1)
hsa-miR-16-2-3p Gemcitabine 60750 NSC613327 approved sensitive cell line (MDA-231)
hsa-miR-16-2-3p Cisplatin 5460033 NSC119875 approved resistant cell line (A549)
hsa-miR-16-2-3p Gemcitabine 60750 NSC613327 approved resistant cell line (Panc1-GR4)

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