miRTarBase - #MIRT074768


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pre-miRNA Information
pre-miRNA hsa-mir-216b   
Genomic Coordinates chr2: 56000714 - 56000795
Description Homo sapiens miR-216b stem-loop
Comment This sequence was identified as a miRNA candidate by Berezikov et al. using RAKE and MPSS techniques .
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-216b-3p
Sequence 49| ACACACUUACCCGUAGAGAUUCUA |72
Evidence Experimental
Experiments Illumina
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 9 2 - 56000739 29233923 MiREDiBase
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1032185572 4 dbSNP
rs1291886633 6 dbSNP
rs1195180466 10 dbSNP
rs761473579 10 dbSNP
rs751204276 12 dbSNP
rs368125248 13 dbSNP
rs755646560 13 dbSNP
rs1307586870 14 dbSNP
rs907200088 16 dbSNP
rs763696104 22 dbSNP
rs762699560 24 dbSNP
Putative Targets

miRNA Expression profile
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Biomarker Information
Biomarker ID Name Type Discovered From Mode Level Source Testing Methods
B5PHM2 miR-216b Safety Biomarker (SAF) Clinical/Experimental Data Expression Increase Plasma MiRNA qPCR analyses
Gene Information
Gene Symbol CNEP1R1   
Synonyms C16orf69, NEP1-R1, NEP1R1, TMEM188, TMP125
Description CTD nuclear envelope phosphatase 1 regulatory subunit 1
Transcript NM_153261   
Expression
Putative miRNA Targets on CNEP1R1
3'UTR of CNEP1R1
(miRNA target sites are highlighted)		 
>CNEP1R1|NM_153261|3'UTR
   1 CAATCTTCACTCATTGTTATGGGACTTAAAATAGCCTTTCTTCGAATAAGTGATACAGCAAAAAGCCATAAAGGATTCCT
  81 TTTGCGGTTGGATATGTAAAGGTCATAGCAGCAACTGACAAGAAGTGTGCAATATTTACCTGGATTATCTTGATGATGGT
 161 GACTCATTATCAGTGCTTTGGTACTTTTGATTACCTGTGTTTCAGTATTAGTGTCACTTTAGTACTTCAGATCCTGCAAA
 241 TATTTTTGCAGATGAAGTATGTATGTATGTTACTAAGTTAAACTTAGAAACAGAACCTCATTCAGTTTTTATAATGTATT
 321 TTTGCAAACTACTGTAAATAGCAAATCAATGCCAATGTTAAACAAAGAGGAAAACGTTGTGTGGACTTTGTTCTCTTGCA
 401 CCAGTATTTCAGGAACATCTGCTTGCCATCCCCACAGCTCTTTAAAACTGGCTATTATGTGTGCCTTTCATTCTTACATT
 481 TCTAATCATACTGCAGGAAAAACATTGGATTCAGCTTAGACTGAGGAAAACTCTCCATTATGTTGTAAGAAATTATAGAT
 561 GTTTTGAGAGACACTTTTTGTTAAACCAGATATTGAACTCCAGCAACTATTGTGGTTATATTTTTAGTTCATTGTTCTCA
 641 TTTAATGCTAAATATCCTTTATATTGCTTTAATAATTTTCTTTTTTTTTTTTTTTTTTTTAGACGGAGTCTCGCTCTGTT
 721 GCCAGGCTGGAGGGCAGTGGCACGATCTTGGCTTTCTGCAACCTCTGCCTCCCAGGTTCAAGCGATTCTCCTGCTTCAGC
 801 CTTCTGAGTAGCTGGGACTACAGGCGCATGCCACCATGCCCAGCTAATTTTTTTGTATTTTTAGTAGAGACGGGGTTTCA
 881 CCACGTTGGCCAGGATGGTTTCGATCTCCTGACCTCGTGATCCTCCTGCCTCATCCTCCCAAAATGCTGGGATTACAGGC
 961 ATAAGCCACCGTGCCTGGCCTCTTTAATAATTTTTAAAATACCCTAAAGGCTTGTGAATATACAAGTCTACTGATAAATT
1041 ATGTATTGTCTGGGAATTTGATAGTCATTGTTTTAGATAACTGGATTTTACGCTGTGGTAGACAGGCTGTGACACTAGTG
1121 TTGCACAGGTGTAATTGGTCATCCTATGCCTTCACCAGAATAACTTGGGAGTGGTGCCAGAAACTAGAGTCTACAATTCT
1201 CACTGTTTAGAGAGTGTTAATGACATACTGTGTATGCATAATAGCCGCATGTACTATAATAGCCCTTAAAATTAAACTAT
1281 TGGGATTGCTGTAAATATTTTAAAGTACTGGAGGTGCCTTTTACCTGTTTATTAGATTTTGAAAAGGTTTAAATTATTTC
1361 ATGAGCAATCTTTTAAATTTCATTTAACATAAAGCTGAAAATTCAATAACAGGATAAAAAAGCTTTTTAACAAGGCTGCC
1441 ATTTAACTTAAATGTGTTCATCTTAGCTTTCACTTGTATAAAATTTGATTCTTTGAACTGCAGCAATAAAACCCTCAGCT
1521 CCTAAGAAGTCTTAAGAGGGTATTCTATATATTCTGCTTTGTTTTATTTTCTGTAAATTTTGTAGGTAAATATGTGCATT
1601 AAAAATAAATACTTTATATATAACTCGTGAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' auCUUAGAGAUGCCCAUUCACACa 5'
            | | ||  ||  | ||||||| 
Target 5' caGCAACT-GACAAG-AAGTGTGc 3'
 109 - 130 144.00 -11.00
2 
miRNA  3' aucuUAGAGAUGCCCA-UUCACACa 5'
              ||:|:|:| | | |||| || 
Target 5' aaatATTTTTGCAGATGAAGTATGt 3'
 238 - 262 132.00 -8.50
3 
miRNA  3' aucuuAGAGAUGCCCAUUCACaca 5'
               |:||| ||  ||||||   
Target 5' tagccTTTCTTCGAATAAGTGata 3'
 32 - 55 127.00 -11.42
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30122903 21 COSMIC
COSN30765961 34 COSMIC
COSN30141267 44 COSMIC
COSN31545958 59 COSMIC
COSN31576173 86 COSMIC
COSN1187443 131 COSMIC
COSN29468168 238 COSMIC
COSN26636484 382 COSMIC
COSN31483866 385 COSMIC
COSN7259026 403 COSMIC
COSN30538901 474 COSMIC
COSN26585386 494 COSMIC
COSN26819482 506 COSMIC
COSN31576923 516 COSMIC
COSN5407391 548 COSMIC
COSN31527671 649 COSMIC
COSN29984854 680 COSMIC
COSN29984306 681 COSMIC
COSN8601723 689 COSMIC
COSN22460987 1034 COSMIC
COSN15310013 1092 COSMIC
COSN30174692 1141 COSMIC
COSN30165586 1223 COSMIC
COSN31555244 1363 COSMIC
COSN31585579 1492 COSMIC
COSN31603660 1532 COSMIC
COSN31609635 1613 COSMIC
COSN31546468 1624 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs747187457 2 dbSNP
rs771129348 4 dbSNP
rs1400444070 5 dbSNP
rs369053494 6 dbSNP
rs746195751 7 dbSNP
rs950265235 10 dbSNP
rs770163275 11 dbSNP
rs747715588 12 dbSNP
rs1174737301 14 dbSNP
rs757827144 15 dbSNP
rs55653857 19 dbSNP
rs775949974 20 dbSNP
rs763553501 21 dbSNP
rs562539278 25 dbSNP
rs1177087763 28 dbSNP
rs779233705 38 dbSNP
rs772835338 42 dbSNP
rs373420066 44 dbSNP
rs766062916 45 dbSNP
rs531670648 47 dbSNP
rs1441589632 54 dbSNP
rs1450720858 55 dbSNP
rs1182034773 57 dbSNP
rs370646179 66 dbSNP
rs1368106241 68 dbSNP
rs1046280001 70 dbSNP
rs185459967 80 dbSNP
rs1472384590 86 dbSNP
rs561603319 87 dbSNP
rs1275267578 88 dbSNP
rs528092040 89 dbSNP
rs1436001800 91 dbSNP
rs1003912631 106 dbSNP
rs1320365063 127 dbSNP
rs1392816397 128 dbSNP
rs1038043074 133 dbSNP
rs898149495 139 dbSNP
rs1455823965 151 dbSNP
rs1396034055 159 dbSNP
rs527312214 168 dbSNP
rs1400452345 170 dbSNP
rs1244684662 171 dbSNP
rs1217242737 172 dbSNP
rs1488346830 175 dbSNP
rs1448332874 184 dbSNP
rs1028256811 189 dbSNP
rs955426587 191 dbSNP
rs34922460 192 dbSNP
rs1008066879 200 dbSNP
rs1218497350 221 dbSNP
rs1365675507 222 dbSNP
rs1020792417 223 dbSNP
rs1400639032 231 dbSNP
rs1339978808 236 dbSNP
rs1339443785 240 dbSNP
rs1296465127 241 dbSNP
rs1175250746 257 dbSNP
rs1437098963 260 dbSNP
rs967495096 270 dbSNP
rs546362775 273 dbSNP
rs1286271602 279 dbSNP
rs1422564912 286 dbSNP
rs925970466 289 dbSNP
rs957408396 290 dbSNP
rs1338053816 291 dbSNP
rs991875896 291 dbSNP
rs1477968502 292 dbSNP
rs916168183 294 dbSNP
rs950314487 296 dbSNP
rs1486609632 306 dbSNP
rs1256523090 309 dbSNP
rs1209092353 310 dbSNP
rs1310241033 331 dbSNP
rs1198618640 343 dbSNP
rs1259243591 350 dbSNP
rs780166468 351 dbSNP
rs1276367349 354 dbSNP
rs908715676 357 dbSNP
rs748258846 360 dbSNP
rs939799321 360 dbSNP
rs771672060 364 dbSNP
rs1491414859 365 dbSNP
rs1171895153 371 dbSNP
rs1465808475 376 dbSNP
rs898226033 377 dbSNP
rs747058329 381 dbSNP
rs996526168 385 dbSNP
rs1256711355 389 dbSNP
rs755023968 390 dbSNP
rs1199097440 394 dbSNP
rs1255749371 399 dbSNP
rs570562070 400 dbSNP
rs1008558650 401 dbSNP
rs1322442421 403 dbSNP
rs4640178 404 dbSNP
rs1227085357 405 dbSNP
rs1188032797 410 dbSNP
rs1376240421 413 dbSNP
rs1332455927 414 dbSNP
rs1446515681 418 dbSNP
rs966518772 426 dbSNP
rs1328901867 430 dbSNP
rs1458958280 430 dbSNP
rs1368506156 438 dbSNP
rs1370015627 444 dbSNP
rs189986920 449 dbSNP
rs1169948544 452 dbSNP
rs1033114645 462 dbSNP
rs957645765 468 dbSNP
rs991514869 472 dbSNP
rs1286642523 478 dbSNP
rs144082948 478 dbSNP
rs1300508372 479 dbSNP
rs1401081898 494 dbSNP
rs1488959498 496 dbSNP
rs535288646 497 dbSNP
rs981642737 506 dbSNP
rs908745328 507 dbSNP
rs1310648125 512 dbSNP
rs1239814769 520 dbSNP
rs774269033 522 dbSNP
rs1325104920 523 dbSNP
rs1306137936 527 dbSNP
rs1388125853 533 dbSNP
rs1391073757 535 dbSNP
rs1292426580 541 dbSNP
rs1218399855 542 dbSNP
rs1279463455 546 dbSNP
rs1320545490 562 dbSNP
rs192972171 566 dbSNP
rs940208943 573 dbSNP
rs1221783997 574 dbSNP
rs150882268 579 dbSNP
rs1255444376 583 dbSNP
rs12935292 586 dbSNP
rs1200811863 593 dbSNP
rs1483600436 621 dbSNP
rs1266949053 631 dbSNP
rs1189493987 636 dbSNP
rs1489325138 646 dbSNP
rs1287321889 655 dbSNP
rs1202446580 675 dbSNP
rs1259895906 676 dbSNP
rs145676549 680 dbSNP
rs1043468644 681 dbSNP
rs1298334972 681 dbSNP
rs1341807757 681 dbSNP
rs1384513746 681 dbSNP
rs1387390971 681 dbSNP
rs769938628 681 dbSNP
rs28419572 685 dbSNP
rs919693213 686 dbSNP
rs1478735028 687 dbSNP
rs60157102 688 dbSNP
rs199696128 689 dbSNP
rs932382399 689 dbSNP
rs1466087984 690 dbSNP
rs1174028797 691 dbSNP
rs1478947520 692 dbSNP
rs1263970737 695 dbSNP
rs79797833 700 dbSNP
rs1193112891 701 dbSNP
rs1258874086 701 dbSNP
rs76059759 702 dbSNP
rs75441817 703 dbSNP
rs1358230097 704 dbSNP
rs546079172 706 dbSNP
rs1255007962 707 dbSNP
rs1399789619 709 dbSNP
rs1299128962 713 dbSNP
rs1342966378 715 dbSNP
rs1049445278 716 dbSNP
rs1398856814 718 dbSNP
rs1338263104 719 dbSNP
rs1336118528 723 dbSNP
rs1305997800 729 dbSNP
rs890768733 739 dbSNP
rs943964214 744 dbSNP
rs183939922 745 dbSNP
rs1467366135 753 dbSNP
rs556116464 762 dbSNP
rs902409398 764 dbSNP
rs372219586 766 dbSNP
rs1370651165 774 dbSNP
rs1188885601 775 dbSNP
rs1353183318 776 dbSNP
rs1215658386 784 dbSNP
rs1254499727 786 dbSNP
rs1200993039 805 dbSNP
rs12709076 806 dbSNP
rs1489131978 807 dbSNP
rs1217434511 816 dbSNP
rs111314750 817 dbSNP
rs1285490023 825 dbSNP
rs1245397963 826 dbSNP
rs1189453778 827 dbSNP
rs1331944461 828 dbSNP
rs1448722726 837 dbSNP
rs893255556 848 dbSNP
rs868448447 849 dbSNP
rs1330954783 850 dbSNP
rs1134181 856 dbSNP
rs535049391 857 dbSNP
rs1134182 858 dbSNP
rs1416011265 868 dbSNP
rs1163971011 871 dbSNP
rs1433337780 871 dbSNP
rs199583170 872 dbSNP
rs1378116976 873 dbSNP
rs1180841815 874 dbSNP
rs369762702 879 dbSNP
rs374468334 880 dbSNP
rs557842319 885 dbSNP
rs971793337 886 dbSNP
rs578084042 895 dbSNP
rs771810540 903 dbSNP
rs1362898686 904 dbSNP
rs1291383828 907 dbSNP
rs371245944 913 dbSNP
rs1319298758 918 dbSNP
rs1015799532 931 dbSNP
rs1312846425 932 dbSNP
rs974244100 944 dbSNP
rs920085541 958 dbSNP
rs1308308616 966 dbSNP
rs1368835453 968 dbSNP
rs932441560 971 dbSNP
rs543541642 972 dbSNP
rs1324215881 978 dbSNP
rs985600367 996 dbSNP
rs1241202329 997 dbSNP
rs1389144411 1002 dbSNP
rs912283651 1005 dbSNP
rs1420880495 1009 dbSNP
rs1380054841 1011 dbSNP
rs1177221493 1015 dbSNP
rs1468277211 1021 dbSNP
rs943704307 1022 dbSNP
rs760175895 1027 dbSNP
rs1288400362 1037 dbSNP
rs1450558527 1040 dbSNP
rs1289450104 1042 dbSNP
rs1218660346 1046 dbSNP
rs1042036829 1074 dbSNP
rs1285042949 1086 dbSNP
rs1221866800 1091 dbSNP
rs766150524 1092 dbSNP
rs180740279 1093 dbSNP
rs1264803324 1096 dbSNP
rs1343686593 1100 dbSNP
rs1300171702 1105 dbSNP
rs1401130393 1108 dbSNP
rs1053667481 1115 dbSNP
rs1488736195 1120 dbSNP
rs1211139639 1124 dbSNP
rs894956299 1128 dbSNP
rs763506974 1136 dbSNP
rs150062829 1144 dbSNP
rs1381773636 1145 dbSNP
rs541596765 1147 dbSNP
rs1164447925 1155 dbSNP
rs1002835696 1158 dbSNP
rs1213331382 1165 dbSNP
rs1015537757 1175 dbSNP
rs1459862695 1177 dbSNP
rs759363377 1178 dbSNP
rs1218847100 1184 dbSNP
rs1321744636 1194 dbSNP
rs995696254 1195 dbSNP
rs1027183473 1200 dbSNP
rs1340391351 1209 dbSNP
rs34794738 1228 dbSNP
rs1450580531 1231 dbSNP
rs1447595396 1233 dbSNP
rs1311826771 1235 dbSNP
rs1360074533 1236 dbSNP
rs1333976706 1246 dbSNP
rs1468952409 1247 dbSNP
rs376303309 1248 dbSNP
rs1172125686 1251 dbSNP
rs1477877327 1257 dbSNP
rs985622788 1258 dbSNP
rs1184676995 1264 dbSNP
rs1484223434 1266 dbSNP
rs184726506 1274 dbSNP
rs1311690600 1277 dbSNP
rs1322064240 1278 dbSNP
rs1235108035 1280 dbSNP
rs1260249690 1281 dbSNP
rs1219277003 1287 dbSNP
rs965091364 1291 dbSNP
rs977786945 1303 dbSNP
rs1256062408 1318 dbSNP
rs923599136 1329 dbSNP
rs367572477 1331 dbSNP
rs527566432 1346 dbSNP
rs1403387645 1349 dbSNP
rs1332994511 1360 dbSNP
rs1054101536 1362 dbSNP
rs1456981661 1369 dbSNP
rs1198652304 1370 dbSNP
rs1167777945 1377 dbSNP
rs1425483863 1380 dbSNP
rs1239631798 1382 dbSNP
rs1482042700 1388 dbSNP
rs1414450171 1389 dbSNP
rs916473766 1390 dbSNP
rs1442567240 1406 dbSNP
rs947901574 1407 dbSNP
rs1199468597 1411 dbSNP
rs1457520290 1415 dbSNP
rs540656018 1436 dbSNP
rs1249672662 1441 dbSNP
rs73579207 1454 dbSNP
rs1322790456 1455 dbSNP
rs907330395 1459 dbSNP
rs144873058 1461 dbSNP
rs1037016738 1466 dbSNP
rs1379542256 1475 dbSNP
rs1310515065 1477 dbSNP
rs897149586 1479 dbSNP
rs549622634 1480 dbSNP
rs1295881449 1486 dbSNP
rs995490803 1506 dbSNP
rs1350347434 1514 dbSNP
rs1423536104 1516 dbSNP
rs569702835 1522 dbSNP
rs1422711824 1524 dbSNP
rs1333386482 1528 dbSNP
rs1381908499 1529 dbSNP
rs1179080924 1541 dbSNP
rs1418712694 1550 dbSNP
rs1357671195 1556 dbSNP
rs1192945870 1558 dbSNP
rs1027667593 1559 dbSNP
rs954282556 1562 dbSNP
rs765271713 1565 dbSNP
rs1220876844 1574 dbSNP
rs1007479126 1576 dbSNP
rs1019772537 1583 dbSNP
rs55777473 1590 dbSNP
rs1315899252 1593 dbSNP
rs1304441260 1602 dbSNP
rs1387966473 1603 dbSNP
rs965163618 1604 dbSNP
rs1302036405 1606 dbSNP
rs1379690383 1610 dbSNP
rs1234898450 1612 dbSNP
rs1276230464 1614 dbSNP
rs189171983 1621 dbSNP
rs549580482 1622 dbSNP
rs1362239159 1624 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Disease 255919.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM714644. RNA binding protein: AGO2. Condition:completeT1 "PAR-CLIP data was present in GSM714645. RNA binding protein: AGO2. Condition:completeT1 ...

- Kishore S; Jaskiewicz L; Burger L; Hausser et al., 2011, Nature methods.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' aucuuagagaugcccauUCACACa 5'
                           |||||| 
Target 5' -----------------AGUGUGc 3'
 		1 - 7
Article - Kishore S; Jaskiewicz L; Burger L; Hausser et al.
- Nature methods, 2011
Cross-linking and immunoprecipitation (CLIP) is increasingly used to map transcriptome-wide binding sites of RNA-binding proteins. We developed a method for CLIP data analysis, and applied it to compare CLIP with photoactivatable ribonucleoside-enhanced CLIP (PAR-CLIP) and to uncover how differences in cross-linking and ribonuclease digestion affect the identified sites. We found only small differences in accuracies of these methods in identifying binding sites of HuR, which binds low-complexity sequences, and Argonaute 2, which has a complex binding specificity. We found that cross-link-induced mutations led to single-nucleotide resolution for both PAR-CLIP and CLIP. Our results confirm the expectation from original CLIP publications that RNA-binding proteins do not protect their binding sites sufficiently under the denaturing conditions used during the CLIP procedure, and we show that extensive digestion with sequence-specific RNases strongly biases the recovered binding sites. This bias can be substantially reduced by milder nuclease digestion conditions.
LinkOut: [PMID: 21572407]
CLIP-seq Support 1 for dataset GSM714644
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / completeT1, repA
Location of target site ENST00000458059.3 | 3UTR | AAGUGUGCAAUAUUUACCUGGAUUAUCUUGAUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 21572407 / GSE28865
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM714645
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / completeT1, repB
Location of target site ENST00000458059.3 | 3UTR | AGUGUGCAAUAUUUACCUGGAUUAUCUUGAUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 21572407 / GSE28865
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
111 hsa-miR-216b-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT071722 CCNK cyclin K 2 2
MIRT074768 CNEP1R1 CTD nuclear envelope phosphatase 1 regulatory subunit 1 2 2
MIRT101407 SSR1 signal sequence receptor subunit 1 2 2
MIRT241289 AASDHPPT aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 2 4
MIRT268292 CCND1 cyclin D1 2 8
MIRT445347 IFNA6 interferon alpha 6 2 2
MIRT446663 MXI1 MAX interactor 1, dimerization protein 2 4
MIRT447595 MSH3 mutS homolog 3 2 2
MIRT448485 SEMA4F ssemaphorin 4F 2 2
MIRT450309 DRAXIN dorsal inhibitory axon guidance protein 2 2
MIRT451850 TXNDC5 thioredoxin domain containing 5 2 2
MIRT483613 SMC5 structural maintenance of chromosomes 5 2 2
MIRT485633 EEPD1 endonuclease/exonuclease/phosphatase family domain containing 1 2 2
MIRT499766 CIRH1A UTP4, small subunit processome component 2 6
MIRT503337 MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 2 2
MIRT513007 MAN1A2 mannosidase alpha class 1A member 2 2 2
MIRT513529 RHOQ ras homolog family member Q 2 4
MIRT521499 RAB11B RAB11B, member RAS oncogene family 2 2
MIRT524335 CRK CRK proto-oncogene, adaptor protein 2 4
MIRT524731 BRI3BP BRI3 binding protein 2 8
MIRT525326 SNX29 sorting nexin 29 2 2
MIRT526264 CCDC169 coiled-coil domain containing 169 2 2
MIRT527428 NRL neural retina leucine zipper 2 2
MIRT527512 ZNF134 zinc finger protein 134 2 2
MIRT528881 ATF3 activating transcription factor 3 2 2
MIRT529578 IGBP1 immunoglobulin binding protein 1 2 4
MIRT531122 ZYG11B zyg-11 family member B, cell cycle regulator 2 2
MIRT531341 TGIF2LX TGFB induced factor homeobox 2 like, X-linked 2 2
MIRT532433 DHX33 DEAH-box helicase 33 2 2
MIRT534032 STX7 syntaxin 7 2 2
MIRT534538 SACS sacsin molecular chaperone 2 4
MIRT538886 BRWD3 bromodomain and WD repeat domain containing 3 2 2
MIRT539628 CD19 CD19 molecule 2 8
MIRT540327 ATAT1 alpha tubulin acetyltransferase 1 2 8
MIRT540353 OCLN occludin 2 6
MIRT540699 ATG10 autophagy related 10 2 4
MIRT541033 STRBP spermatid perinuclear RNA binding protein 2 8
MIRT541945 NBPF10 NBPF member 10 2 4
MIRT543505 PLS1 plastin 1 2 2
MIRT551164 UBTF upstream binding transcription factor, RNA polymerase I 2 4
MIRT551790 ZNF117 zinc finger protein 117 2 4
MIRT553227 TWF1 twinfilin actin binding protein 1 2 2
MIRT559622 AKIRIN2 akirin 2 2 2
MIRT559719 ADORA2B adenosine A2b receptor 2 2
MIRT564600 ZNF781 zinc finger protein 781 2 2
MIRT567015 KLHL15 kelch like family member 15 2 2
MIRT569564 C7orf26 chromosome 7 open reading frame 26 2 2
MIRT572155 DDX3X DEAD-box helicase 3, X-linked 2 2
MIRT575399 Zdhhc22 zinc finger, DHHC-type containing 22 2 5
MIRT607322 PKNOX1 PBX/knotted 1 homeobox 1 2 4
MIRT607953 NFAM1 NFAT activating protein with ITAM motif 1 2 10
MIRT607979 ZDHHC22 zinc finger DHHC-type containing 22 2 7
MIRT609145 ZNF610 zinc finger protein 610 2 4
MIRT609206 GOSR2 golgi SNAP receptor complex member 2 2 4
MIRT609338 HRASLS5 HRAS like suppressor family member 5 2 2
MIRT609725 KIF5C kinesin family member 5C 2 4
MIRT610014 MED24 mediator complex subunit 24 2 4
MIRT610407 TMEM245 transmembrane protein 245 2 2
MIRT610559 NBPF14 NBPF member 14 2 2
MIRT611291 PAGR1 PAXIP1 associated glutamate rich protein 1 2 2
MIRT611399 ATP9A ATPase phospholipid transporting 9A (putative) 2 2
MIRT611432 C11orf45 chromosome 11 open reading frame 45 2 4
MIRT611710 SLFN13 schlafen family member 13 2 2
MIRT611721 ANK3 ankyrin 3 2 2
MIRT611830 CACNG8 calcium voltage-gated channel auxiliary subunit gamma 8 2 4
MIRT611977 ZNF175 zinc finger protein 175 2 2
MIRT612073 CEP135 centrosomal protein 135 2 4
MIRT612195 CCDC77 coiled-coil domain containing 77 2 2
MIRT612320 UBE2H ubiquitin conjugating enzyme E2 H 2 2
MIRT612354 TNRC6C trinucleotide repeat containing 6C 2 4
MIRT612635 PTEN phosphatase and tensin homolog 2 2
MIRT612773 MLXIP MLX interacting protein 2 4
MIRT612788 MAP3K9 mitogen-activated protein kinase kinase kinase 9 2 4
MIRT612853 JAZF1 JAZF zinc finger 1 2 2
MIRT612965 GID4 GID complex subunit 4 homolog 2 6
MIRT613132 DUSP6 dual specificity phosphatase 6 2 2
MIRT613388 AAK1 AP2 associated kinase 1 2 2
MIRT615058 CRY2 cryptochrome circadian clock 2 2 4
MIRT616046 HSPA12B heat shock protein family A (Hsp70) member 12B 2 2
MIRT617962 SEPT9 septin 9 2 2
MIRT618413 ATP2A2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 2 2
MIRT622448 RNF213 ring finger protein 213 2 2
MIRT623611 IPCEF1 interaction protein for cytohesin exchange factors 1 2 2
MIRT625709 SHROOM1 shroom family member 1 2 2
MIRT630646 ELK1 ELK1, ETS transcription factor 2 2
MIRT630970 KIAA2022 neurite extension and migration factor 2 2
MIRT631003 SPAG7 sperm associated antigen 7 2 2
MIRT640385 EMC1 ER membrane protein complex subunit 1 2 4
MIRT641064 WBSCR17 polypeptide N-acetylgalactosaminyltransferase 17 2 2
MIRT641780 ZDHHC7 zinc finger DHHC-type containing 7 2 4
MIRT646310 MPHOSPH8 M-phase phosphoprotein 8 2 2
MIRT646624 CENPL centromere protein L 2 2
MIRT659653 CDH2 cadherin 2 2 2
MIRT666161 SP1 Sp1 transcription factor 2 2
MIRT667638 LHFPL2 LHFPL tetraspan subfamily member 2 2 2
MIRT668988 CHRFAM7A CHRNA7 (exons 5-10) and FAM7A (exons A-E) fusion 2 2
MIRT680949 PLCXD1 phosphatidylinositol specific phospholipase C X domain containing 1 2 2
MIRT695238 PBK PDZ binding kinase 2 2
MIRT700036 RPL22 ribosomal protein L22 2 2
MIRT707685 GPR50 G protein-coupled receptor 50 2 2
MIRT709324 HMBOX1 homeobox containing 1 2 2
MIRT710176 MTRF1L mitochondrial translational release factor 1 like 2 2
MIRT712007 F9 coagulation factor IX 2 2
MIRT714219 C10orf71 chromosome 10 open reading frame 71 2 2
MIRT714496 HSPA4 heat shock protein family A (Hsp70) member 4 2 2
MIRT714575 GALNT10 polypeptide N-acetylgalactosaminyltransferase 10 2 2
MIRT715982 TFRC transferrin receptor 2 2
MIRT717870 TRAPPC3L trafficking protein particle complex 3 like 2 2
MIRT718289 MINA ribosomal oxygenase 2 2 2
MIRT725200 PTRF caveolae associated protein 1 2 2
MIRT737338 TPX2 TPX2, microtubule nucleation factor 3 0
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-216b Perfluorooctane sulfonate NULL 74483 Microarray zebrafish embryos 20878907 2011 up-regulated
miR-216b 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) NULL 15625 Microarray embryos 22921993 2012 up-regulated
miR-216b Reversine NULL 210332 Microarray C2C12 myoblast cells 24513286 2014 up-regulated
miR-216b Hydroxycamptothecin (HCPT) NULL 97226 Microarray human Tenon's fibroblasts (HTFs) 24681041 2014 down-regulated
miR-216b Hydroxycamptothecin (HCPT) NULL 97226 Quantitative real-time PCR human Tenon's fibroblasts (HTFs) 24681041 2014 down-regulated
miR-216b Curcumin NULL 969516 Quantitative real-time PCR Y79 RB cells. 22510010 2012 down-regulated
miR-216b Doxorubicin approved 31703 Quantitative real-time PCR heart 22859947 2012 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-216b Paclitaxel 36314 NSC125973 approved sensitive cell line (A2780)
hsa-mir-216b Cisplatin 5460033 NSC119875 approved sensitive cell line (A2780)
hsa-miR-216b-3p Tripterygium wilfordii Hook F resistant tissue
hsa-miR-216b-3p Gefitinib 123631 NSC715055 approved sensitive cell line (HCC827)
hsa-miR-216b-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (MGC-803)

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