miRTarBase - #MIRT076945


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pre-miRNA Information
pre-miRNA hsa-mir-548t   
Genomic Coordinates chr4: 173268160 - 173268233
Description Homo sapiens miR-548t stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-548t-3p
Sequence 46| AAAAACCACAAUUACUUUUGCACCA |70
Evidence Not_experimental
Experiments
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 2 4 + 173268206 29233923 MiREDiBase
A-to-I 3 4 + 173268207 29233923 MiREDiBase
A-to-I 4 4 + 173268208 29233923 MiREDiBase
A-to-I 10 4 + 173268214 29233923 MiREDiBase
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs73872515 5 dbSNP
rs1426966747 6 dbSNP
rs1158401109 21 dbSNP
rs943938928 24 dbSNP
Putative Targets

Gene Information
Gene Symbol PCGF2   
Synonyms MEL-18, RNF110, ZNF144
Description polycomb group ring finger 2
Transcript NM_007144   
Expression
Putative miRNA Targets on PCGF2
3'UTR of PCGF2
(miRNA target sites are highlighted)		 
>PCGF2|NM_007144|3'UTR
   1 GGCCAGGGACCCTCTCCCTTCTTCCAGCCAAGCCTCTCCACTCCTTCCACTTTTTCTGGGCCCTTTTTTCCACCTCTTCT
  81 ACTTTCCCCAGCTCTTCCCACCTTGGGGGTGGGGGGCGGGTTTTATAAATAAATATATATATATATGTACATAGGAAAAA
 161 CCAAATATACATACTTATTTTCTATGGACCAACCAGATTAATTTAAATGCCACAGGAAACAAACTTTATGTGTGTGTGTA
 241 TGTGTGGAAAATGGTGTTCATTTTTTTTGGGGGGGGTCTTGTGTAATTTGCTGTTTTTGGGGGTGCCTGGAGATGAACTG
 321 GATGGGCCACTGGAGTCTCAATAAAGCTCTGCACCATCCTCGCTGTTTCCCAAGGCAGGTGGTGTGTTGGGGGCCCCTTC
 401 AGACCCAAAGCTTTAGGCATGATTCCAACTGGCTGCATATAGGAGTCAGTTAGAATCGTTTCTTTCTCTCCCCGTTTCTC
 481 TCCCCATCTTGGCTGCTGTCCTGCCTCTGACCAGTGGCCGCCCCCCACGTTGTTGAATGTCCAGAAATTGCTAAGAACAG
 561 TGCCTTTTACAAATGCAGTTTATCCCTGGTTCTGAGGAGCAAGTGCAGGGTGGAGGTGGCACCTGCATCACCTCCTCCTC
 641 TTGCAGTGGAAACTTTGTGCAAAGAATAGATAGTTCTGCCTCTTTTTTTTTTTTTCCTGTGTGTGTGGCCTTTGCATCAT
 721 TTATCTTGTGGAAAAGAAGATTCAGGCCCTGAGAGGTCTCAGCTCTTGGAGGAGGGCTAAGGCTTTAGCATTGTGAAGCG
 801 CTGCACCCCCACCAACCTTACCCTCACCGGGGAACCCTCACTAGCAGGACTGGTGGTGGAGTCTCACCTGGGGCCTAGAG
 881 TGGAAGTGGGGGTGGGTTAACCTCACACAAGCACAGATCCCAGACTTTGCCAGAGGCAAACAGCCTTCCAATTGCCCCTC
 961 CACCCCCAGCTGAGGCCCGGTCACCTGGTCAGGACAGAGCAACTGCATCTAAAAGCACAAGAAGACAGAAACCTGTAAGC
1041 TCTGACCCCACCCCCACCCCTTGAGAGGTCAGCGGACCACCTCCTTAGGGACAGACCCTGGCAGGTCGCTGCCCACCGAG
1121 ATTTCCTCAAGTGTGCATAGATCTGAGAGGAGTCGGGAGTCGAGACTCGAGATTCCATCATAGCGTAGGTGTGTGGGGTT
1201 GGGAGCCCCCTGATGGGCTTGTCTGTGTTTGCACCTTGTCCTGTGTCTGAGGTCCTGTGACTGTACCCTCCTTTGCCCTG
1281 GGACATCTGTATCTCTTGGCTTTGTAATAAATGCTGCATACTTTCTAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' accacguuuuCAUU-AAC-ACCAAAAa 5'
                    |||| ||| || |||| 
Target 5' ggggtcttgtGTAATTTGCTGTTTTTg 3'
 273 - 299 127.00 -9.10
2 
miRNA  3' accACGUUUUCAUUAA-----CACCAAAAa 5'
             | |||| | |:||      ||||| | 
Target 5' tttTACAAATGCAGTTTATCCCTGGTTCTg 3'
 565 - 594 126.00 -6.55
3 
miRNA  3' acCACGUUUUCAUUAACACCAAAAa 5'
            |||:::||  ||   |||| || 
Target 5' atGTGTGGAA--AA---TGGTGTTc 3'
 240 - 259 124.00 -5.27
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1350928396 1 dbSNP
rs377749543 9 dbSNP
rs953417116 13 dbSNP
rs141585937 19 dbSNP
rs975877842 22 dbSNP
rs962245366 23 dbSNP
rs1359982196 28 dbSNP
rs1178308232 29 dbSNP
rs376471012 33 dbSNP
rs1203681351 35 dbSNP
rs1277388200 39 dbSNP
rs747546989 40 dbSNP
rs1030873311 49 dbSNP
rs999830118 51 dbSNP
rs534053659 60 dbSNP
rs1034948802 61 dbSNP
rs568255159 63 dbSNP
rs1011886287 70 dbSNP
rs1061140 74 dbSNP
rs1182627975 83 dbSNP
rs1371100718 87 dbSNP
rs1404628140 91 dbSNP
rs1015265817 95 dbSNP
rs939151007 100 dbSNP
rs1272321040 111 dbSNP
rs368418582 117 dbSNP
rs907363730 117 dbSNP
rs1312216307 132 dbSNP
rs1226260132 136 dbSNP
rs1277498884 136 dbSNP
rs1299846915 136 dbSNP
rs1209729026 139 dbSNP
rs1217165365 142 dbSNP
rs1453663803 144 dbSNP
rs1352350958 145 dbSNP
rs557470857 147 dbSNP
rs756266788 147 dbSNP
rs777067529 147 dbSNP
rs940929435 147 dbSNP
rs1447221599 151 dbSNP
rs1290670839 152 dbSNP
rs1373111425 176 dbSNP
rs1472439274 183 dbSNP
rs756894383 184 dbSNP
rs909479606 188 dbSNP
rs984748425 194 dbSNP
rs1027848135 202 dbSNP
rs1388200952 207 dbSNP
rs996760735 207 dbSNP
rs537147613 210 dbSNP
rs921960266 214 dbSNP
rs976161308 222 dbSNP
rs966176406 225 dbSNP
rs1358988774 228 dbSNP
rs569311139 228 dbSNP
rs1031238778 230 dbSNP
rs1306647349 233 dbSNP
rs552672290 236 dbSNP
rs1267822775 238 dbSNP
rs977965137 240 dbSNP
rs968347097 244 dbSNP
rs1359868290 247 dbSNP
rs1261879930 251 dbSNP
rs1022171949 253 dbSNP
rs1175412473 260 dbSNP
rs1413048803 261 dbSNP
rs1185411479 263 dbSNP
rs1040604839 265 dbSNP
rs1159653140 267 dbSNP
rs1060338 268 dbSNP
rs1011833919 269 dbSNP
rs1409440225 269 dbSNP
rs1455863998 269 dbSNP
rs1160495469 270 dbSNP
rs1385817231 274 dbSNP
rs1395524229 276 dbSNP
rs1342785471 277 dbSNP
rs138572530 277 dbSNP
rs555557931 277 dbSNP
rs1289194514 278 dbSNP
rs1327490960 283 dbSNP
rs753801312 288 dbSNP
rs1034688704 298 dbSNP
rs1343742171 301 dbSNP
rs1236424961 303 dbSNP
rs1257579320 305 dbSNP
rs1003687402 307 dbSNP
rs896934455 328 dbSNP
rs1036911287 335 dbSNP
rs760079760 340 dbSNP
rs540477925 341 dbSNP
rs1229399908 348 dbSNP
rs1049332878 352 dbSNP
rs763952410 354 dbSNP
rs568223592 356 dbSNP
rs932260600 359 dbSNP
rs372690822 361 dbSNP
rs1042769109 362 dbSNP
rs1307922104 367 dbSNP
rs1349089526 378 dbSNP
rs755872962 379 dbSNP
rs924068712 381 dbSNP
rs978290115 393 dbSNP
rs967863459 394 dbSNP
rs946844015 395 dbSNP
rs1286825957 397 dbSNP
rs915111057 400 dbSNP
rs1347945026 401 dbSNP
rs1230571855 419 dbSNP
rs915329281 426 dbSNP
rs990892371 435 dbSNP
rs937851647 440 dbSNP
rs1483948420 442 dbSNP
rs1177587332 449 dbSNP
rs866258491 451 dbSNP
rs1266357512 454 dbSNP
rs1860837 457 dbSNP
rs546524179 464 dbSNP
rs1003225700 473 dbSNP
rs1168576442 475 dbSNP
rs1321422943 475 dbSNP
rs544917961 483 dbSNP
rs1014522678 486 dbSNP
rs1463918324 492 dbSNP
rs1299131189 493 dbSNP
rs1060342 507 dbSNP
rs535112584 520 dbSNP
rs1384768854 521 dbSNP
rs1409541264 522 dbSNP
rs1166608481 526 dbSNP
rs708692 527 dbSNP
rs1344237089 528 dbSNP
rs908238709 529 dbSNP
rs1264687580 531 dbSNP
rs1005745653 533 dbSNP
rs887941754 536 dbSNP
rs774600390 538 dbSNP
rs1049280951 541 dbSNP
rs1465807094 546 dbSNP
rs545462980 551 dbSNP
rs576540830 559 dbSNP
rs766429062 568 dbSNP
rs1207772225 570 dbSNP
rs780675751 572 dbSNP
rs1040754093 574 dbSNP
rs762952221 579 dbSNP
rs1368293895 593 dbSNP
rs1028496151 598 dbSNP
rs1259413129 599 dbSNP
rs1456714238 605 dbSNP
rs1327574781 606 dbSNP
rs996568588 608 dbSNP
rs944727146 609 dbSNP
rs964885041 612 dbSNP
rs1019060422 622 dbSNP
rs773699393 639 dbSNP
rs1215125469 641 dbSNP
rs902754388 647 dbSNP
rs1311910674 649 dbSNP
rs1042468544 653 dbSNP
rs946843542 667 dbSNP
rs1407193484 681 dbSNP
rs1469096321 682 dbSNP
rs768243256 682 dbSNP
rs1226717803 683 dbSNP
rs3066488 683 dbSNP
rs1491029912 684 dbSNP
rs566327867 684 dbSNP
rs1187685052 696 dbSNP
rs1374994407 696 dbSNP
rs33995757 696 dbSNP
rs386386025 696 dbSNP
rs5820265 696 dbSNP
rs915060152 696 dbSNP
rs202231429 697 dbSNP
rs1301691580 698 dbSNP
rs1449215750 698 dbSNP
rs758756201 698 dbSNP
rs760388095 698 dbSNP
rs1376891374 699 dbSNP
rs1298388864 701 dbSNP
rs1434694083 703 dbSNP
rs1328201821 707 dbSNP
rs1282420164 708 dbSNP
rs959255899 708 dbSNP
rs7210453 722 dbSNP
rs148289101 723 dbSNP
rs1386719525 741 dbSNP
rs1042619656 746 dbSNP
rs1295125735 751 dbSNP
rs1458169195 753 dbSNP
rs1258701984 755 dbSNP
rs1472464184 762 dbSNP
rs1011337473 772 dbSNP
rs1179638104 776 dbSNP
rs1349229217 777 dbSNP
rs927903931 791 dbSNP
rs553874276 794 dbSNP
rs549605063 800 dbSNP
rs1450816491 801 dbSNP
rs961063186 805 dbSNP
rs1055621760 812 dbSNP
rs1015700455 816 dbSNP
rs868646078 817 dbSNP
rs1268955273 818 dbSNP
rs1193293370 825 dbSNP
rs533745133 828 dbSNP
rs1375811475 829 dbSNP
rs1224506225 833 dbSNP
rs111988561 853 dbSNP
rs1345772315 858 dbSNP
rs554553725 873 dbSNP
rs538156057 888 dbSNP
rs1019205984 891 dbSNP
rs1234919494 896 dbSNP
rs1275524060 909 dbSNP
rs1009590543 930 dbSNP
rs772678561 935 dbSNP
rs775732069 943 dbSNP
rs1455191318 949 dbSNP
rs939945857 952 dbSNP
rs569248571 956 dbSNP
rs570914364 965 dbSNP
rs1180785398 968 dbSNP
rs984019601 970 dbSNP
rs1176709598 974 dbSNP
rs1330679596 976 dbSNP
rs1354853640 978 dbSNP
rs370251783 979 dbSNP
rs772549367 985 dbSNP
rs1274479156 987 dbSNP
rs1042820407 989 dbSNP
rs946792907 995 dbSNP
rs1304168725 999 dbSNP
rs893897546 1000 dbSNP
rs1275609692 1001 dbSNP
rs1054843608 1002 dbSNP
rs952483959 1003 dbSNP
rs920934343 1008 dbSNP
rs1469487002 1011 dbSNP
rs1193722057 1015 dbSNP
rs796997805 1017 dbSNP
rs1229959423 1018 dbSNP
rs927818153 1026 dbSNP
rs1420044565 1032 dbSNP
rs1176846293 1039 dbSNP
rs982034403 1042 dbSNP
rs975600091 1048 dbSNP
rs1321268236 1051 dbSNP
rs1392555415 1054 dbSNP
rs11653368 1055 dbSNP
rs1396219638 1056 dbSNP
rs552605655 1061 dbSNP
rs144991968 1063 dbSNP
rs952400880 1069 dbSNP
rs1028095378 1073 dbSNP
rs1405904375 1086 dbSNP
rs1321677839 1094 dbSNP
rs1228123183 1095 dbSNP
rs1336540664 1096 dbSNP
rs1455622288 1100 dbSNP
rs1362396970 1101 dbSNP
rs1213878496 1102 dbSNP
rs966821056 1107 dbSNP
rs1021634410 1108 dbSNP
rs773148114 1110 dbSNP
rs1281209316 1112 dbSNP
rs1411371037 1113 dbSNP
rs974879241 1117 dbSNP
rs964893623 1118 dbSNP
rs1162565066 1129 dbSNP
rs1419697518 1132 dbSNP
rs1011119604 1136 dbSNP
rs769183102 1138 dbSNP
rs141292317 1139 dbSNP
rs1307298907 1141 dbSNP
rs1407485251 1145 dbSNP
rs1403786142 1150 dbSNP
rs1320305067 1151 dbSNP
rs1002319370 1152 dbSNP
rs1447898485 1154 dbSNP
rs1291851396 1155 dbSNP
rs547115531 1162 dbSNP
rs745511175 1165 dbSNP
rs1046494877 1168 dbSNP
rs1010862410 1169 dbSNP
rs1174742085 1169 dbSNP
rs1284295992 1170 dbSNP
rs939850570 1181 dbSNP
rs1185684587 1184 dbSNP
rs1413383526 1185 dbSNP
rs1259400422 1193 dbSNP
rs1475409692 1197 dbSNP
rs1188992763 1203 dbSNP
rs1182026914 1206 dbSNP
rs1055123650 1212 dbSNP
rs938123604 1221 dbSNP
rs1258434954 1224 dbSNP
rs908329787 1226 dbSNP
rs76161689 1228 dbSNP
rs1385702542 1232 dbSNP
rs561563842 1235 dbSNP
rs146587185 1237 dbSNP
rs201692804 1238 dbSNP
rs1329545742 1242 dbSNP
rs975030319 1246 dbSNP
rs1288043390 1249 dbSNP
rs531130384 1251 dbSNP
rs1240678143 1252 dbSNP
rs912324081 1262 dbSNP
rs930980015 1269 dbSNP
rs977106991 1277 dbSNP
rs770407449 1278 dbSNP
rs1282368108 1282 dbSNP
rs967283559 1283 dbSNP
rs1342185736 1285 dbSNP
rs1021122018 1289 dbSNP
rs1334305565 1299 dbSNP
rs1394884355 1303 dbSNP
rs990173858 1318 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM545216. RNA binding protein: AGO2. Condition:miR-124 transfection ...

- Hafner M; Landthaler M; Burger L; Khorshid et al., 2010, Cell.

Article - Hafner M; Landthaler M; Burger L; Khorshid et al.
- Cell, 2010
RNA transcripts are subject to posttranscriptional gene regulation involving hundreds of RNA-binding proteins (RBPs) and microRNA-containing ribonucleoprotein complexes (miRNPs) expressed in a cell-type dependent fashion. We developed a cell-based crosslinking approach to determine at high resolution and transcriptome-wide the binding sites of cellular RBPs and miRNPs. The crosslinked sites are revealed by thymidine to cytidine transitions in the cDNAs prepared from immunopurified RNPs of 4-thiouridine-treated cells. We determined the binding sites and regulatory consequences for several intensely studied RBPs and miRNPs, including PUM2, QKI, IGF2BP1-3, AGO/EIF2C1-4 and TNRC6A-C. Our study revealed that these factors bind thousands of sites containing defined sequence motifs and have distinct preferences for exonic versus intronic or coding versus untranslated transcript regions. The precise mapping of binding sites across the transcriptome will be critical to the interpretation of the rapidly emerging data on genetic variation between individuals and how these variations contribute to complex genetic diseases.
LinkOut: [PMID: 20371350]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293
Disease 7703.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "HITS-CLIP data was present in GSM714642. RNA binding protein: AGO2. Condition:completeT1 "PAR-CLIP data was present in GSM714644. RNA binding protein: AGO2. Condition:completeT1 ...

- Kishore S; Jaskiewicz L; Burger L; Hausser et al., 2011, Nature methods.

Article - Kishore S; Jaskiewicz L; Burger L; Hausser et al.
- Nature methods, 2011
Cross-linking and immunoprecipitation (CLIP) is increasingly used to map transcriptome-wide binding sites of RNA-binding proteins. We developed a method for CLIP data analysis, and applied it to compare CLIP with photoactivatable ribonucleoside-enhanced CLIP (PAR-CLIP) and to uncover how differences in cross-linking and ribonuclease digestion affect the identified sites. We found only small differences in accuracies of these methods in identifying binding sites of HuR, which binds low-complexity sequences, and Argonaute 2, which has a complex binding specificity. We found that cross-link-induced mutations led to single-nucleotide resolution for both PAR-CLIP and CLIP. Our results confirm the expectation from original CLIP publications that RNA-binding proteins do not protect their binding sites sufficiently under the denaturing conditions used during the CLIP procedure, and we show that extensive digestion with sequence-specific RNases strongly biases the recovered binding sites. This bias can be substantially reduced by milder nuclease digestion conditions.
LinkOut: [PMID: 21572407]
Experimental Support 3 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Disease 7703.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM1065667. RNA binding protein: AGO1. Condition:4-thiouridine ...

- Memczak S; Jens M; Elefsinioti A; Torti F; et al., 2013, Nature.

Article - Memczak S; Jens M; Elefsinioti A; Torti F; et al.
- Nature, 2013
Circular RNAs (circRNAs) in animals are an enigmatic class of RNA with unknown function. To explore circRNAs systematically, we sequenced and computationally analysed human, mouse and nematode RNA. We detected thousands of well-expressed, stable circRNAs, often showing tissue/developmental-stage-specific expression. Sequence analysis indicated important regulatory functions for circRNAs. We found that a human circRNA, antisense to the cerebellar degeneration-related protein 1 transcript (CDR1as), is densely bound by microRNA (miRNA) effector complexes and harbours 63 conserved binding sites for the ancient miRNA miR-7. Further analyses indicated that CDR1as functions to bind miR-7 in neuronal tissues. Human CDR1as expression in zebrafish impaired midbrain development, similar to knocking down miR-7, suggesting that CDR1as is a miRNA antagonist with a miRNA-binding capacity ten times higher than any other known transcript. Together, our data provide evidence that circRNAs form a large class of post-transcriptional regulators. Numerous circRNAs form by head-to-tail splicing of exons, suggesting previously unrecognized regulatory potential of coding sequences.
LinkOut: [PMID: 23446348]
CLIP-seq Support 1 for dataset GSM714642
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293 / completeT1, repA
Location of target site ENST00000360797.2 | 3UTR | UUUUAUAAAUAAAUAUAUAUAUAUAUGUACAUAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 21572407 / GSE28865
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM545216
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / miR-124 transfection
Location of target site ENST00000360797.2 | 3UTR | UUUUAUAAAUAAAUAUAUAUAUAUA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 20371350 / GSE21578
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM714644
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / completeT1, repA
Location of target site ENST00000360797.2 | 3UTR | UUUUAUAAAUAAAUAUAUAUAUAUAUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 21572407 / GSE28865
CLIP-seq Viewer Link
CLIP-seq Support 4 for dataset GSM1065667
Method / RBP PAR-CLIP / AGO1
Cell line / Condition HEK293 / 4-thiouridine, ML_MM_6
Location of target site ENST00000360797.2 | 3UTR | UUUUAUAAAUAAAUAUAUAUAUAUA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23446348 / GSE43573
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
168 hsa-miR-548t-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT059365 ANP32E acidic nuclear phosphoprotein 32 family member E 2 2
MIRT072839 ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 2 6
MIRT076945 PCGF2 polycomb group ring finger 2 2 6
MIRT083941 TFAP2C transcription factor AP-2 gamma 2 2
MIRT085401 ETS2 ETS proto-oncogene 2, transcription factor 2 2
MIRT109790 KLHL15 kelch like family member 15 2 2
MIRT114046 AKAP11 A-kinase anchoring protein 11 2 10
MIRT130165 TXNIP thioredoxin interacting protein 2 6
MIRT150013 MIDN midnolin 2 2
MIRT181258 ASH1L ASH1 like histone lysine methyltransferase 2 2
MIRT205594 NCL nucleolin 2 2
MIRT222253 ACTB actin beta 2 4
MIRT245653 EIF5AL1 eukaryotic translation initiation factor 5A-like 1 2 4
MIRT250947 CDK5R1 cyclin dependent kinase 5 regulatory subunit 1 2 4
MIRT252497 NWD1 NACHT and WD repeat domain containing 1 2 2
MIRT271990 ARF1 ADP ribosylation factor 1 2 4
MIRT280804 RNF11 ring finger protein 11 2 2
MIRT293803 FEM1A fem-1 homolog A 2 2
MIRT318231 RREB1 ras responsive element binding protein 1 2 2
MIRT341455 ATP6V0B ATPase H+ transporting V0 subunit b 2 2
MIRT347413 CEBPG CCAAT/enhancer binding protein gamma 2 4
MIRT351860 PLEKHA3 pleckstrin homology domain containing A3 2 2
MIRT357983 GRPEL2 GrpE like 2, mitochondrial 2 2
MIRT377094 PPP1CB protein phosphatase 1 catalytic subunit beta 2 2
MIRT407303 IGFBP5 insulin like growth factor binding protein 5 2 2
MIRT441564 LMOD3 leiomodin 3 2 2
MIRT442364 ZC3H12C zinc finger CCCH-type containing 12C 2 2
MIRT443228 ARL5B ADP ribosylation factor like GTPase 5B 2 2
MIRT443404 HMX3 H6 family homeobox 3 2 2
MIRT446055 NR5A2 nuclear receptor subfamily 5 group A member 2 2 2
MIRT448277 ZNF652 zinc finger protein 652 2 2
MIRT450822 KCNB1 potassium voltage-gated channel subfamily B member 1 2 2
MIRT453016 CCDC115 coiled-coil domain containing 115 2 17
MIRT454463 PPP2R2B protein phosphatase 2 regulatory subunit Bbeta 2 2
MIRT456360 CITED2 Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2 2 2
MIRT460007 DNALI1 dynein axonemal light intermediate chain 1 2 2
MIRT463154 ZNF385A zinc finger protein 385A 2 6
MIRT463766 YPEL2 yippee like 2 2 2
MIRT468310 SFT2D2 SFT2 domain containing 2 2 2
MIRT470668 POLR2D RNA polymerase II subunit D 2 4
MIRT478517 CTTN cortactin 2 2
MIRT480507 C11orf57 chromosome 11 open reading frame 57 2 2
MIRT484718 INHBA inhibin beta A subunit 2 12
MIRT485494 HMGN2 high mobility group nucleosomal binding domain 2 2 2
MIRT487302 SLC38A9 solute carrier family 38 member 9 2 2
MIRT487771 ANKEF1 ankyrin repeat and EF-hand domain containing 1 2 16
MIRT491876 YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta 2 2
MIRT494304 CEP120 centrosomal protein 120 2 2
MIRT495396 TRIM24 tripartite motif containing 24 2 2
MIRT495646 CDK1 cyclin dependent kinase 1 2 2
MIRT496665 TMEM237 transmembrane protein 237 2 2
MIRT496837 ZNF460 zinc finger protein 460 2 2
MIRT498638 CHD4 chromodomain helicase DNA binding protein 4 2 10
MIRT503928 FBXL13 F-box and leucine rich repeat protein 13 2 4
MIRT506063 PPP2R2A protein phosphatase 2 regulatory subunit Balpha 2 2
MIRT506582 MIER3 MIER family member 3 2 4
MIRT506606 MAT2A methionine adenosyltransferase 2A 2 4
MIRT506844 KIF23 kinesin family member 23 2 6
MIRT508536 RPP14 ribonuclease P/MRP subunit p14 2 4
MIRT509669 ZNF354B zinc finger protein 354B 2 10
MIRT511170 MBNL3 muscleblind like splicing regulator 3 2 6
MIRT512147 COX6B1 cytochrome c oxidase subunit 6B1 2 2
MIRT512831 ID4 inhibitor of DNA binding 4, HLH protein 2 6
MIRT514558 XRCC3 X-ray repair cross complementing 3 2 4
MIRT515856 AJAP1 adherens junctions associated protein 1 2 4
MIRT521848 PNISR PNN interacting serine and arginine rich protein 2 4
MIRT525364 SYNM synemin 2 2
MIRT527120 ARHGAP15 Rho GTPase activating protein 15 2 2
MIRT527271 FBLN2 fibulin 2 2 2
MIRT527439 COL4A3 collagen type IV alpha 3 chain 2 2
MIRT527658 CD300E CD300e molecule 2 2
MIRT528334 TBC1D22B TBC1 domain family member 22B 2 2
MIRT529033 EXOC8 exocyst complex component 8 2 2
MIRT529321 PDE5A phosphodiesterase 5A 2 2
MIRT529677 TRPV2 transient receptor potential cation channel subfamily V member 2 2 2
MIRT529846 SMTN smoothelin 2 2
MIRT530385 ZNF431 zinc finger protein 431 2 2
MIRT530913 GPR85 G protein-coupled receptor 85 2 2
MIRT531794 KDR kinase insert domain receptor 2 2
MIRT532246 KLF2 Kruppel like factor 2 2 4
MIRT532658 CBX7 chromobox 7 2 2
MIRT533630 TMX3 thioredoxin related transmembrane protein 3 2 2
MIRT534811 RAB33B RAB33B, member RAS oncogene family 2 2
MIRT534975 PSD3 pleckstrin and Sec7 domain containing 3 2 2
MIRT536588 ITPKB inositol-trisphosphate 3-kinase B 2 2
MIRT536779 HNRNPD heterogeneous nuclear ribonucleoprotein D 2 2
MIRT538764 CABLES1 Cdk5 and Abl enzyme substrate 1 2 2
MIRT539294 ANGEL2 angel homolog 2 2 2
MIRT539621 SHISA9 shisa family member 9 2 2
MIRT539651 BUB1 BUB1 mitotic checkpoint serine/threonine kinase 2 2
MIRT540347 OPHN1 oligophrenin 1 2 2
MIRT540413 PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 2 2
MIRT541396 CDC27 cell division cycle 27 2 2
MIRT542916 HSBP1 heat shock factor binding protein 1 2 2
MIRT544710 EIF5A eukaryotic translation initiation factor 5A 2 4
MIRT544998 MFF mitochondrial fission factor 2 4
MIRT553289 TSPAN3 tetraspanin 3 2 2
MIRT553455 TNRC6C trinucleotide repeat containing 6C 2 2
MIRT553782 TAF13 TATA-box binding protein associated factor 13 2 2
MIRT554656 ROBO1 roundabout guidance receptor 1 2 2
MIRT555104 PURB purine rich element binding protein B 2 2
MIRT557235 HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 2 2
MIRT560861 GAL3ST3 galactose-3-O-sulfotransferase 3 2 2
MIRT561545 SON SON DNA binding protein 2 2
MIRT561554 SLMO2 PRELI domain containing 3B 2 2
MIRT563764 ZNF678 zinc finger protein 678 2 2
MIRT565653 SIX4 SIX homeobox 4 2 2
MIRT568080 CELF2 CUGBP Elav-like family member 2 2 2
MIRT568759 MYBL1 MYB proto-oncogene like 1 2 2
MIRT569078 CADM2 cell adhesion molecule 2 2 2
MIRT569509 THYN1 thymocyte nuclear protein 1 2 2
MIRT571268 CDKN2AIP CDKN2A interacting protein 2 2
MIRT571809 PHF19 PHD finger protein 19 2 2
MIRT572554 DKK3 dickkopf WNT signaling pathway inhibitor 3 2 2
MIRT573782 SLC24A4 solute carrier family 24 member 4 2 4
MIRT576441 Ccdc115 coiled-coil domain containing 115 2 10
MIRT576712 Slc30a3 solute carrier family 30 (zinc transporter), member 3 2 3
MIRT608377 PIWIL2 piwi like RNA-mediated gene silencing 2 2 2
MIRT608484 NKTR natural killer cell triggering receptor 2 6
MIRT610186 FAM49A family with sequence similarity 49 member A 2 2
MIRT611631 EDIL3 EGF like repeats and discoidin domains 3 2 2
MIRT613534 TRA2B transformer 2 beta homolog 2 2
MIRT616221 PTPN11 protein tyrosine phosphatase, non-receptor type 11 2 2
MIRT622370 SALL1 spalt like transcription factor 1 2 2
MIRT624371 CDK12 cyclin dependent kinase 12 2 2
MIRT624995 ZNF665 zinc finger protein 665 2 4
MIRT626875 AP3B1 adaptor related protein complex 3 beta 1 subunit 2 2
MIRT627737 RAP2B RAP2B, member of RAS oncogene family 2 4
MIRT628490 ADAT2 adenosine deaminase, tRNA specific 2 2 2
MIRT633647 PLEKHG7 pleckstrin homology and RhoGEF domain containing G7 2 4
MIRT634028 SLC30A3 solute carrier family 30 member 3 2 3
MIRT635923 GLTSCR2 NOP53 ribosome biogenesis factor 2 2
MIRT638287 SERBP1 SERPINE1 mRNA binding protein 1 2 2
MIRT641959 RNF115 ring finger protein 115 2 2
MIRT643573 CTNNA3 catenin alpha 3 2 2
MIRT645180 NOL9 nucleolar protein 9 2 4
MIRT647497 ZNF639 zinc finger protein 639 2 2
MIRT647682 PCK1 phosphoenolpyruvate carboxykinase 1 2 2
MIRT648422 MYOZ3 myozenin 3 2 2
MIRT650113 ZCCHC9 zinc finger CCHC-type containing 9 2 2
MIRT651076 ZNF518B zinc finger protein 518B 2 4
MIRT651415 ZADH2 zinc binding alcohol dehydrogenase domain containing 2 2 2
MIRT651456 XKR4 XK related 4 2 2
MIRT653619 SLC30A4 solute carrier family 30 member 4 2 2
MIRT653637 SLC30A1 solute carrier family 30 member 1 2 2
MIRT654896 POU2F1 POU class 2 homeobox 1 2 2
MIRT656483 MAP3K9 mitogen-activated protein kinase kinase kinase 9 2 2
MIRT658016 GABRA4 gamma-aminobutyric acid type A receptor alpha4 subunit 2 2
MIRT658041 FZD10 frizzled class receptor 10 2 2
MIRT660093 BTBD3 BTB domain containing 3 2 2
MIRT663923 MAGEF1 MAGE family member F1 2 2
MIRT665882 TGIF2 TGFB induced factor homeobox 2 2 2
MIRT669051 CEP128 centrosomal protein 128 2 2
MIRT669711 AAGAB alpha and gamma adaptin binding protein 2 2
MIRT686812 SNX2 sorting nexin 2 2 4
MIRT689883 SOD2 superoxide dismutase 2 2 2
MIRT693274 GLRX2 glutaredoxin 2 2 4
MIRT697056 BCAR1 BCAR1, Cas family scaffolding protein 2 2
MIRT703297 GID4 GID complex subunit 4 homolog 2 2
MIRT704087 DYRK2 dual specificity tyrosine phosphorylation regulated kinase 2 2 2
MIRT707719 CDC6 cell division cycle 6 2 2
MIRT708136 GK5 glycerol kinase 5 (putative) 2 2
MIRT709212 KLHL30 kelch like family member 30 2 2
MIRT710062 RWDD2A RWD domain containing 2A 2 2
MIRT712770 POU6F2 POU class 6 homeobox 2 2 2
MIRT715073 TMTC1 transmembrane and tetratricopeptide repeat containing 1 2 2
MIRT715387 TADA3 transcriptional adaptor 3 2 2
MIRT717712 NCKAP1 NCK associated protein 1 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-548t Paclitaxel 36314 NSC125973 approved sensitive cell line (W1)
hsa-mir-548t Cisplatin 5460033 NSC119875 approved sensitive cell line (W1)
hsa-mir-548t Doxorubicin 31703 NSC123127 approved sensitive cell line (W1)
hsa-mir-548t Topotecan 60699 NSC609699 approved sensitive cell line (W1)
hsa-mir-548t Vincristine 5978 approved sensitive cell line (W1)
hsa-miR-548t-3p Oxaliplatin 6857599 NSC266046 approved sensitive High Colorectal Cancer cell line (SW480, HCT-116)
hsa-miR-548t-3p Gefitinib 123631 NSC715055 approved sensitive cell line (PC9)
hsa-miR-548t-3p Osimertinib 71496458 NSC779217 approved sensitive cell line (HCC827)

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