miRTarBase - #MIRT077512


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pre-miRNA Information
pre-miRNA hsa-mir-367   
Genomic Coordinates chr4: 112647874 - 112647941
Synonyms MIRN367, hsa-mir-367, MIR367
Description Homo sapiens miR-367 stem-loop
Comment None
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-367-3p
Sequence 44| AAUUGCACUUUAGCAAUGGUGA |65
Evidence Experimental
Experiments Cloned
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSN24411246 17 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs535597757 1 dbSNP
rs1013348949 11 dbSNP
rs896333735 12 dbSNP
rs751269136 14 dbSNP
rs1163501507 16 dbSNP
rs757092597 21 dbSNP
Putative Targets

Gene Information
Gene Symbol UBE2Z   
Synonyms HOYS7, USE1
Description ubiquitin conjugating enzyme E2 Z
Transcript NM_023079   
Expression
Putative miRNA Targets on UBE2Z
3'UTR of UBE2Z
(miRNA target sites are highlighted)		 
>UBE2Z|NM_023079|3'UTR
   1 ACCCTGCTCCCATCTCCCCTTCCCCCACTCAAGAGTCCCAGCAGAATCCCTTCCCCCCACCCCAGGGATGGAGAGGCACT
  81 GTGTATCTCCCTCCAGACTCGAAGTCATCCTGCAAGATGGCAAGAACCAAGCAAGCTCCGATCCCAGGGTGTGGGAGTGG
 161 GGGCCTGTTCCCGGTCTGACCTCCTTGGCACTGGAGCATCTGGGGCTTCGTTCATCCATTCATCCCGTATCAGGGGCCAA
 241 GGTACCTTTACAGGAGCACCTAGAGCGAGGGCCTTTGGCAAAAACAAAACAACCAACACACCTCTCCACAGGGCCAGCTC
 321 CTTAGGGATAAGTGGAAGATGGAAATTGCAATTCCAAGAGGGAGTGTGCCCAAATGATTTATGGGGATACCTGGAAGGGA
 401 GCTTGGGGTGGGGGCTGTCTGTGACACTTAAGCAGTCTGGGTGGTTGTCTATTTGTCTGTCTTCAGTCTTGAAGCAGGGC
 481 TTCCCAATGCCCTTTTCCTCCCTGCCTTCCTTCCCCCATTATTTCCCACAGGCCAGCATAATTTTGTTTTTCCTAATTTA
 561 TAGTCACTGTTCTAGACAGACCAAAGAGAAGGAACAGTGGTGGAGTCTAGGCTGCTGATCAGTAAGCTTTACCTAGCACC
 641 TGAGCACCTTTCTCCCCTCCCCTCTTTCCTCACCCTTTTCTAGATGTAAGACAGAAAGTAAATGTGACTGGGACTTAACC
 721 AAGGTCTTGGTAAAGCCTGCATGGCACCGTAAGAAGCTGAAAATACTGTTTGTTCCCGCAATCACTGATTTGAAAAGTTC
 801 CCAACACAGGCAGCTGCTGTGTATATGGGATTAGAGCCACTACATAGAATAGTCTCTTACAGATTTTCATAAATACTAGT
 881 CACAATAAGGGTATTTTTCTTGGGGGTGGAGTAAGGGGGAGACTGATGCTAGTCCTTGTTGTATTTTGTTGGGCTGTCCT
 961 TGTGTATTTTCACCCCAGCCTGTAGTCCTCCTCACTTCAACCCCAGGGATTTTTGGGGAGCAAGGGTAGCCAATGGCAGA
1041 GGGGGTTGGGGCTGGGACTCTGGAGGCTCCTCCCCTTCTTTCTCTTCCTTCCGCCTCCCCCGTGCCCCCAGCTGCTCTTG
1121 TCACTGTCTCTGATGGGTATTTGCCTGGCTTTGTTGCTTCTCTATCTGTATTTAGCTGCAGTGATCCTTTAGCTGGTTGG
1201 CTCAGAAAAAAAAAAATGTGCTTTAGGTGCCCTGTAATCCTGGGCATCAAGGGAATCCATCCTTCCCCTTTTTGATATGT
1281 TCTCCCCGTACTTCCAGATTTATTGTTATGGCTCCCAGTGGGTATTGGCGATTCTTGTGATGCAGGGCCTCAGTCAGTGT
1361 CCAGCCATGCATAAGGGAGAGGATAGTGTGTACCTGCCCTGCCCTCTGCTATGAAGGTCTCTGCCTTGTGGATCATGGGA
1441 CTCCCCTTGGAGGATCTGTGCAAAGGGGGGCTGGGCACAAAGGAGAATGTCCTATTTGGGAGGGCAGGAAGCAAAGGAAC
1521 TGGACAGGGATTGGTGGGCTTGGGGAACGGAAGTTTATCTTGGATACCCTTGAAGAGGCTGGGTCTCTTCACATGAAGAT
1601 CGAAAAGGGACCCTGCTTCCAATTTCCCTCTTCCATTCCTCGAGCTACTCCAGGGCTTAGAAGAATGCTCTTGGTCTGTG
1681 GGTCCAGTGTTGTCTGTCATCCATTTAAGTGTTCCCACTTTCAAGTGACAATCCTCTCCTTGGCCCTGCCATAGGGCAGA
1761 GCATGTCTGGCATAGCAGCCTGACTTTTATGCCCTAATCTTGAGTTGAGGAAATATATGCACAGGAGTCAAAGAGATGTC
1841 TTTATATCTGACTGTATATAAATGAAGTTTTTTTGTTTTTTTTGTTTTCCTTTTTGGTGCAATAAAGTTTGTTTTGGCAG
1921 AAGGAGAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' aguGGUAACGAUUUCACGUUAa 5'
             :| || :|  :||||||| 
Target 5' tttTCCTTTTT--GGTGCAATa 3'
 1885 - 1904 147.00 -8.40
2 
miRNA  3' aguGGUAACGAUUU---CACGUUaa 5'
             || |||  ::|   ||||||  
Target 5' ctcCCCTTGGAGGATCTGTGCAAag 3'
 1441 - 1465 131.00 -7.60
3 
miRNA  3' aguGGUAACGAUUUCAC-GUUAa 5'
             ||| | :| ||||| |||| 
Target 5' ttcCCACT-TTCAAGTGACAATc 3'
 1712 - 1733 130.00 -7.30
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30504296 8 COSMIC
COSN30493296 34 COSMIC
COSN31590255 74 COSMIC
COSN20719776 90 COSMIC
COSN31480834 114 COSMIC
COSN19660126 228 COSMIC
COSN21666629 238 COSMIC
COSN31547722 380 COSMIC
COSN20093312 400 COSMIC
COSN30539327 415 COSMIC
COSN5840537 592 COSMIC
COSN8603318 736 COSMIC
COSN17427059 915 COSMIC
COSN27393052 1217 COSMIC
COSN28988544 1217 COSMIC
COSN32063139 1289 COSMIC
COSN31518881 1370 COSMIC
COSN31550703 1387 COSMIC
COSN31577392 1448 COSMIC
COSN31610752 1532 COSMIC
COSN8837905 1549 COSMIC
COSN20114135 1574 COSMIC
COSN31553242 1810 COSMIC
COSN31521849 1875 COSMIC
COSN19658217 1884 COSMIC
rs2088138 228 GWAS
rs1057902 1093 GWAS
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs780694428 2 dbSNP
rs370323738 3 dbSNP
rs1341988774 4 dbSNP
rs1350498988 5 dbSNP
rs747862204 12 dbSNP
rs1278579838 14 dbSNP
rs769238796 14 dbSNP
rs1342769798 15 dbSNP
rs1310580342 16 dbSNP
rs1230720889 18 dbSNP
rs375182716 24 dbSNP
rs752464191 25 dbSNP
rs1046088854 27 dbSNP
rs373393504 31 dbSNP
rs1201204532 32 dbSNP
rs1424865541 33 dbSNP
rs1258509336 36 dbSNP
rs772731933 37 dbSNP
rs1187273543 42 dbSNP
rs955795056 49 dbSNP
rs762880607 53 dbSNP
rs1415711385 57 dbSNP
rs906179137 58 dbSNP
rs758061472 59 dbSNP
rs879203141 63 dbSNP
rs1215162215 64 dbSNP
rs540148072 65 dbSNP
rs1052612318 67 dbSNP
rs1203609997 79 dbSNP
rs559871901 81 dbSNP
rs893520545 85 dbSNP
rs926707887 86 dbSNP
rs974090766 86 dbSNP
rs1428607185 90 dbSNP
rs1344352059 92 dbSNP
rs1318760155 93 dbSNP
rs1429343196 96 dbSNP
rs1415969068 101 dbSNP
rs1475571403 101 dbSNP
rs777646756 102 dbSNP
rs1195368424 108 dbSNP
rs1427318508 114 dbSNP
rs529109663 118 dbSNP
rs1175671009 119 dbSNP
rs558437177 119 dbSNP
rs1429736252 123 dbSNP
rs1467441645 133 dbSNP
rs548771558 136 dbSNP
rs917115571 137 dbSNP
rs562588657 140 dbSNP
rs781158895 141 dbSNP
rs1299443903 144 dbSNP
rs1019644451 151 dbSNP
rs1361207621 156 dbSNP
rs1270492280 163 dbSNP
rs902818810 163 dbSNP
rs965755149 164 dbSNP
rs972718389 165 dbSNP
rs1325450302 168 dbSNP
rs1462204145 170 dbSNP
rs1396741122 173 dbSNP
rs527679814 174 dbSNP
rs1284557484 180 dbSNP
rs1420856310 182 dbSNP
rs952744978 183 dbSNP
rs529682476 188 dbSNP
rs547853159 189 dbSNP
rs996630049 190 dbSNP
rs1237251485 191 dbSNP
rs1192581805 195 dbSNP
rs551393992 204 dbSNP
rs1468666754 209 dbSNP
rs1260540256 210 dbSNP
rs571303708 211 dbSNP
rs534453806 221 dbSNP
rs948027083 227 dbSNP
rs2088138 228 dbSNP
rs1302455715 232 dbSNP
rs891306865 232 dbSNP
rs927692963 235 dbSNP
rs934996559 239 dbSNP
rs1441858380 247 dbSNP
rs1373488490 249 dbSNP
rs1296458921 253 dbSNP
rs371315163 266 dbSNP
rs572097149 266 dbSNP
rs148572493 267 dbSNP
rs893573402 269 dbSNP
rs962972477 286 dbSNP
rs1010590983 291 dbSNP
rs1429836938 302 dbSNP
rs1174677433 309 dbSNP
rs1442726232 317 dbSNP
rs995460855 321 dbSNP
rs1043233130 332 dbSNP
rs1434838401 335 dbSNP
rs1175183580 336 dbSNP
rs1156615864 343 dbSNP
rs1033671290 347 dbSNP
rs1232997447 359 dbSNP
rs1363030379 367 dbSNP
rs1345673887 369 dbSNP
rs748419470 380 dbSNP
rs1234756239 385 dbSNP
rs542960145 400 dbSNP
rs1160124338 403 dbSNP
rs1363164263 409 dbSNP
rs1391089323 410 dbSNP
rs1403861351 411 dbSNP
rs1299998685 416 dbSNP
rs1020287555 420 dbSNP
rs1413421249 420 dbSNP
rs1303236357 426 dbSNP
rs1375386120 431 dbSNP
rs1370309463 442 dbSNP
rs1390191805 448 dbSNP
rs1306710442 452 dbSNP
rs965623245 452 dbSNP
rs1317943234 455 dbSNP
rs1362476107 464 dbSNP
rs1242583977 468 dbSNP
rs1418185534 484 dbSNP
rs556512664 485 dbSNP
rs1408014466 487 dbSNP
rs994588330 499 dbSNP
rs1359018344 502 dbSNP
rs1223226433 503 dbSNP
rs971264628 505 dbSNP
rs1256714161 507 dbSNP
rs977290152 509 dbSNP
rs1025626895 510 dbSNP
rs554890722 519 dbSNP
rs78183148 523 dbSNP
rs772271394 528 dbSNP
rs935931316 535 dbSNP
rs879392472 536 dbSNP
rs1231532363 547 dbSNP
rs754944006 547 dbSNP
rs1249518230 555 dbSNP
rs1398350533 563 dbSNP
rs920949722 573 dbSNP
rs1288681611 583 dbSNP
rs1419523457 589 dbSNP
rs984192965 596 dbSNP
rs932364194 599 dbSNP
rs1161013991 606 dbSNP
rs558485216 634 dbSNP
rs916453123 640 dbSNP
rs969626143 646 dbSNP
rs1473932147 651 dbSNP
rs1416590972 653 dbSNP
rs1188527847 662 dbSNP
rs1425519328 664 dbSNP
rs1382935274 684 dbSNP
rs1259338825 689 dbSNP
rs1204343462 690 dbSNP
rs1423642032 693 dbSNP
rs981929807 695 dbSNP
rs15563 698 dbSNP
rs1212114069 704 dbSNP
rs1004383305 717 dbSNP
rs1294021119 721 dbSNP
rs1351167140 730 dbSNP
rs760982011 736 dbSNP
rs935236006 749 dbSNP
rs1325217189 750 dbSNP
rs752445256 767 dbSNP
rs1383123955 768 dbSNP
rs1037196207 769 dbSNP
rs1298177560 773 dbSNP
rs1322112773 776 dbSNP
rs540109810 778 dbSNP
rs995738773 779 dbSNP
rs771444084 796 dbSNP
rs1165037560 809 dbSNP
rs1459325974 814 dbSNP
rs1033619209 835 dbSNP
rs1192461526 837 dbSNP
rs959415992 840 dbSNP
rs1249710247 845 dbSNP
rs1247014408 846 dbSNP
rs1191945520 853 dbSNP
rs1292082805 855 dbSNP
rs550495041 858 dbSNP
rs1211722241 859 dbSNP
rs1273830495 859 dbSNP
rs553667689 860 dbSNP
rs1305876841 861 dbSNP
rs1251233918 869 dbSNP
rs573888085 872 dbSNP
rs1250749155 884 dbSNP
rs3744611 886 dbSNP
rs1344720033 892 dbSNP
rs1025063078 894 dbSNP
rs1438199336 901 dbSNP
rs946501224 907 dbSNP
rs967229362 913 dbSNP
rs35412283 920 dbSNP
rs1388003181 923 dbSNP
rs1393763440 930 dbSNP
rs1241064989 936 dbSNP
rs977237732 944 dbSNP
rs777332932 949 dbSNP
rs759111902 955 dbSNP
rs764843058 956 dbSNP
rs114544818 957 dbSNP
rs990080055 960 dbSNP
rs1436133800 961 dbSNP
rs920894277 963 dbSNP
rs1169154772 975 dbSNP
rs1344964011 983 dbSNP
rs551250375 986 dbSNP
rs562587672 989 dbSNP
rs1349132043 991 dbSNP
rs1467668539 991 dbSNP
rs1335080290 999 dbSNP
rs1275058243 1005 dbSNP
rs1057897 1014 dbSNP
rs912307126 1017 dbSNP
rs1453611260 1026 dbSNP
rs780199445 1034 dbSNP
rs939795734 1038 dbSNP
rs1286241277 1042 dbSNP
rs1372338443 1043 dbSNP
rs1037144206 1045 dbSNP
rs55685312 1047 dbSNP
rs1359939120 1048 dbSNP
rs1425671248 1051 dbSNP
rs1174503806 1054 dbSNP
rs1468827551 1056 dbSNP
rs1304298462 1061 dbSNP
rs28384242 1063 dbSNP
rs898687057 1067 dbSNP
rs1183003447 1068 dbSNP
rs1214000677 1071 dbSNP
rs545134568 1073 dbSNP
rs1256019133 1075 dbSNP
rs1486188094 1079 dbSNP
rs931538900 1079 dbSNP
rs1281215238 1083 dbSNP
rs1057902 1093 dbSNP
rs895101744 1094 dbSNP
rs1200507253 1095 dbSNP
rs1278377099 1096 dbSNP
rs1260991691 1100 dbSNP
rs888442786 1102 dbSNP
rs1210375314 1103 dbSNP
rs1212861353 1105 dbSNP
rs1238792151 1106 dbSNP
rs1005680990 1108 dbSNP
rs763695949 1112 dbSNP
rs527304002 1115 dbSNP
rs1399116302 1116 dbSNP
rs902576602 1118 dbSNP
rs1023730283 1137 dbSNP
rs1473604187 1140 dbSNP
rs1415830109 1146 dbSNP
rs999627356 1154 dbSNP
rs1473428932 1157 dbSNP
rs969467435 1159 dbSNP
rs957200164 1165 dbSNP
rs1419636069 1180 dbSNP
rs1283107760 1182 dbSNP
rs183523260 1189 dbSNP
rs1209019992 1198 dbSNP
rs1330567668 1200 dbSNP
rs751349199 1201 dbSNP
rs1028237220 1204 dbSNP
rs1325699418 1206 dbSNP
rs201929916 1206 dbSNP
rs954134729 1206 dbSNP
rs986471283 1206 dbSNP
rs912238268 1207 dbSNP
rs982370083 1211 dbSNP
rs1164327835 1212 dbSNP
rs1174954217 1218 dbSNP
rs757060295 1225 dbSNP
rs1185349968 1228 dbSNP
rs567930192 1234 dbSNP
rs988008406 1237 dbSNP
rs1250535452 1251 dbSNP
rs1220191685 1255 dbSNP
rs1336571732 1256 dbSNP
rs530352744 1263 dbSNP
rs946386861 1266 dbSNP
rs1298100493 1267 dbSNP
rs1289501796 1268 dbSNP
rs1342496641 1269 dbSNP
rs1220388791 1275 dbSNP
rs985725201 1276 dbSNP
rs1322752876 1278 dbSNP
rs1219526885 1280 dbSNP
rs550343444 1281 dbSNP
rs1444870086 1283 dbSNP
rs113236693 1284 dbSNP
rs1437269536 1288 dbSNP
rs866794801 1289 dbSNP
rs1168914036 1292 dbSNP
rs7221215 1299 dbSNP
rs538702827 1301 dbSNP
rs1391119513 1303 dbSNP
rs1046366857 1310 dbSNP
rs1250747293 1316 dbSNP
rs999576691 1316 dbSNP
rs901328801 1326 dbSNP
rs558651244 1331 dbSNP
rs1268727788 1338 dbSNP
rs930246788 1341 dbSNP
rs1202302492 1348 dbSNP
rs1032429906 1350 dbSNP
rs1478645582 1350 dbSNP
rs1230334485 1352 dbSNP
rs1345542592 1356 dbSNP
rs1308595486 1365 dbSNP
rs1300827501 1372 dbSNP
rs1174628020 1373 dbSNP
rs1220078642 1374 dbSNP
rs867349933 1376 dbSNP
rs866183830 1385 dbSNP
rs1160195986 1388 dbSNP
rs1362527997 1392 dbSNP
rs1310458542 1394 dbSNP
rs1433229944 1396 dbSNP
rs1394906111 1397 dbSNP
rs1174874004 1398 dbSNP
rs1028604104 1402 dbSNP
rs192998454 1403 dbSNP
rs1302637555 1404 dbSNP
rs1174985119 1405 dbSNP
rs1472018663 1412 dbSNP
rs1252436166 1420 dbSNP
rs1207273844 1426 dbSNP
rs1484551828 1434 dbSNP
rs781106346 1438 dbSNP
rs1211026993 1440 dbSNP
rs1005565173 1443 dbSNP
rs1314180464 1445 dbSNP
rs1437128644 1465 dbSNP
rs1304882717 1466 dbSNP
rs534685601 1467 dbSNP
rs1413516040 1469 dbSNP
rs1207074478 1470 dbSNP
rs1375174007 1479 dbSNP
rs1023608940 1493 dbSNP
rs905296556 1494 dbSNP
rs750362080 1495 dbSNP
rs1466177782 1509 dbSNP
rs1003615964 1511 dbSNP
rs1276366981 1528 dbSNP
rs375342301 1529 dbSNP
rs1471967146 1539 dbSNP
rs1348322207 1548 dbSNP
rs1474198052 1549 dbSNP
rs1479812743 1549 dbSNP
rs1255147872 1550 dbSNP
rs1182239036 1552 dbSNP
rs1484152141 1554 dbSNP
rs754988922 1554 dbSNP
rs1035296608 1558 dbSNP
rs1222844260 1569 dbSNP
rs144120233 1571 dbSNP
rs1255571022 1572 dbSNP
rs370886107 1572 dbSNP
rs113522189 1575 dbSNP
rs113446783 1578 dbSNP
rs919676302 1581 dbSNP
rs931100399 1586 dbSNP
rs956562579 1589 dbSNP
rs185251725 1591 dbSNP
rs1219534576 1594 dbSNP
rs990984153 1602 dbSNP
rs145544916 1603 dbSNP
rs542597475 1615 dbSNP
rs1360378778 1626 dbSNP
rs1201698327 1628 dbSNP
rs1022175285 1634 dbSNP
rs967909209 1636 dbSNP
rs1231527599 1642 dbSNP
rs1456411227 1661 dbSNP
rs147694058 1663 dbSNP
rs778981845 1666 dbSNP
rs1160762730 1668 dbSNP
rs985777672 1669 dbSNP
rs1179671698 1670 dbSNP
rs910201560 1671 dbSNP
rs576160999 1674 dbSNP
rs1425311036 1675 dbSNP
rs772310523 1682 dbSNP
rs565856862 1711 dbSNP
rs3205390 1718 dbSNP
rs551454124 1732 dbSNP
rs1188122608 1735 dbSNP
rs930132323 1740 dbSNP
rs1423013897 1743 dbSNP
rs935316196 1744 dbSNP
rs1162961008 1760 dbSNP
rs1266526834 1762 dbSNP
rs1391600770 1764 dbSNP
rs1306091343 1765 dbSNP
rs777908726 1768 dbSNP
rs1297358134 1774 dbSNP
rs1433827166 1783 dbSNP
rs1365479696 1795 dbSNP
rs1192571280 1800 dbSNP
rs1405845102 1801 dbSNP
rs1047229793 1807 dbSNP
rs910151356 1809 dbSNP
rs941572710 1811 dbSNP
rs1371079903 1817 dbSNP
rs1441136304 1827 dbSNP
rs1167736393 1828 dbSNP
rs893883757 1830 dbSNP
rs1045498604 1832 dbSNP
rs1049556817 1835 dbSNP
rs1378604001 1844 dbSNP
rs905182823 1845 dbSNP
rs1243378339 1847 dbSNP
rs889631258 1847 dbSNP
rs189626966 1855 dbSNP
rs1479951873 1859 dbSNP
rs1019954535 1868 dbSNP
rs1229594676 1868 dbSNP
rs1274285679 1868 dbSNP
rs1056553110 1872 dbSNP
rs753542757 1872 dbSNP
rs993788008 1873 dbSNP
rs1329961704 1875 dbSNP
rs1307413686 1876 dbSNP
rs1343147215 1876 dbSNP
rs1372225245 1876 dbSNP
rs1430149651 1876 dbSNP
rs564987923 1876 dbSNP
rs71369239 1876 dbSNP
rs952439833 1877 dbSNP
rs1477837775 1878 dbSNP
rs566448111 1879 dbSNP
rs527415185 1880 dbSNP
rs990986718 1881 dbSNP
rs1201097464 1884 dbSNP
rs200294094 1885 dbSNP
rs1009367560 1889 dbSNP
rs1271434214 1889 dbSNP
rs11557620 1890 dbSNP
rs1022060735 1895 dbSNP
rs916717976 1897 dbSNP
rs967961158 1903 dbSNP
rs1240443570 1904 dbSNP
rs1278674520 1905 dbSNP
rs1198322355 1907 dbSNP
rs1442981257 1919 dbSNP
rs3179960 1921 dbSNP
rs747389446 1922 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Disease 65264.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM714644. RNA binding protein: AGO2. Condition:completeT1 "PAR-CLIP data was present in GSM714645. RNA binding protein: AGO2. Condition:completeT1 ...

- Kishore S; Jaskiewicz L; Burger L; Hausser et al., 2011, Nature methods.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' aguGGUAACGAUUUCACGUUAa 5'
             :| || :|  :||||||| 
Target 5' uuuUCCUUUUU--GGUGCAAUa 3'
 		1 - 20
Article - Kishore S; Jaskiewicz L; Burger L; Hausser et al.
- Nature methods, 2011
Cross-linking and immunoprecipitation (CLIP) is increasingly used to map transcriptome-wide binding sites of RNA-binding proteins. We developed a method for CLIP data analysis, and applied it to compare CLIP with photoactivatable ribonucleoside-enhanced CLIP (PAR-CLIP) and to uncover how differences in cross-linking and ribonuclease digestion affect the identified sites. We found only small differences in accuracies of these methods in identifying binding sites of HuR, which binds low-complexity sequences, and Argonaute 2, which has a complex binding specificity. We found that cross-link-induced mutations led to single-nucleotide resolution for both PAR-CLIP and CLIP. Our results confirm the expectation from original CLIP publications that RNA-binding proteins do not protect their binding sites sufficiently under the denaturing conditions used during the CLIP procedure, and we show that extensive digestion with sequence-specific RNases strongly biases the recovered binding sites. This bias can be substantially reduced by milder nuclease digestion conditions.
LinkOut: [PMID: 21572407]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions MCF7
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in SRR1045082. RNA binding protein: AGO2. Condition:Untreated ...

- Farazi TA; Ten Hoeve JJ; Brown M; et al., 2014, Genome biology.

Article - Farazi TA; Ten Hoeve JJ; Brown M; et al.
- Genome biology, 2014
BACKGROUND: Various microRNAs (miRNAs) are up- or downregulated in tumors. However, the repression of cognate miRNA targets responsible for the phenotypic effects of this dysregulation in patients remains largely unexplored. To define miRNA targets and associated pathways, together with their relationship to outcome in breast cancer, we integrated patient-paired miRNA-mRNA expression data with a set of validated miRNA targets and pathway inference. RESULTS: To generate a biochemically-validated set of miRNA-binding sites, we performed argonaute-2 photoactivatable-ribonucleoside-enhanced crosslinking and immunoprecipitation (AGO2-PAR-CLIP) in MCF7 cells. We then defined putative miRNA-target interactions using a computational model, which ranked and selected additional TargetScan-predicted interactions based on features of our AGO2-PAR-CLIP binding-site data. We subselected modeled interactions according to the abundance of their constituent miRNA and mRNA transcripts in tumors, and we took advantage of the variability of miRNA expression within molecular subtypes to detect miRNA repression. Interestingly, our data suggest that miRNA families control subtype-specific pathways; for example, miR-17, miR-19a, miR-25, and miR-200b show high miRNA regulatory activity in the triple-negative, basal-like subtype, whereas miR-22 and miR-24 do so in the HER2 subtype. An independent dataset validated our findings for miR-17 and miR-25, and showed a correlation between the expression levels of miR-182 targets and overall patient survival. Pathway analysis associated miR-17, miR-19a, and miR-200b with leukocyte transendothelial migration. CONCLUSIONS: We combined PAR-CLIP data with patient expression data to predict regulatory miRNAs, revealing potential therapeutic targets and prognostic markers in breast cancer.
LinkOut: [PMID: 24398324]
CLIP-seq Support 1 for dataset GSM714644
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / completeT1, repA
Location of target site ENST00000360943.5 | 3UTR | UUUGUUUUCCUUUUUGGUGCAAUAAAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 21572407 / GSE28865
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM714645
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / completeT1, repB
Location of target site ENST00000360943.5 | 3UTR | UUUUCCUUUUUGGUGCAAUAAAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 21572407 / GSE28865
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset SRR1045082
Method / RBP PAR-CLIP / AGO2
Cell line / Condition MCF7 / Untreated
Location of target site ENST00000360943.5 | 3UTR | UUUUCCUUUUUGGUGCAAUAAAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 24398324 / SRX388831
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE28260 Renal cortex and medulla 0.888 2.5e-5 0.762 1.2e-3 13 Click to see details
GSE28544 Breast cancer -0.577 1.6e-3 -0.598 1.0e-3 24 Click to see details
GSE42095 Differentiated embryonic stem cells -0.395 3.1e-2 -0.494 8.3e-3 23 Click to see details
GSE19350 CNS germ cell tumors 0.516 4.3e-2 0.531 3.8e-2 12 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis 0.382 4.8e-2 0.254 1.4e-1 20 Click to see details
GSE21849 B cell lymphoma 0.247 9.8e-2 0.163 2.0e-1 29 Click to see details
GSE27834 Pluripotent stem cells -0.309 1.2e-1 -0.303 1.3e-1 16 Click to see details
GSE26953 Aortic valvular endothelial cells 0.245 1.2e-1 0.242 1.3e-1 24 Click to see details
GSE38226 Liver fibrosis -0.263 1.2e-1 -0.177 2.2e-1 21 Click to see details
GSE32688 Pancreatic cancer 0.198 1.4e-1 0.278 6.2e-2 32 Click to see details
GSE21687 Ependynoma primary tumors -0.122 1.7e-1 -0.277 1.3e-2 64 Click to see details
GSE17306 Multiple myeloma -0.139 1.7e-1 0.329 1.0e-2 49 Click to see details
GSE17498 Multiple myeloma -0.105 2.6e-1 0.002 5.0e-1 40 Click to see details
GSE38974 Chronic obstructive pulmonary disease 0.109 3.0e-1 0.285 8.4e-2 25 Click to see details
GSE14794 Lymphoblastoid cells 0.053 3.1e-1 0.069 2.6e-1 90 Click to see details
GSE15076 Monocyte-derived dendritic cells -0.105 4.3e-1 -0.100 4.4e-1 5 Click to see details
GSE15076 Monocyte-derived dendritic cells -0.105 4.3e-1 -0.100 4.4e-1 5 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
255 hsa-miR-367-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT055315 DUSP5 dual specificity phosphatase 5 2 8
MIRT055791 PLEKHA1 pleckstrin homology domain containing A1 2 12
MIRT057114 DDIT4 DNA damage inducible transcript 4 2 4
MIRT059663 GATAD2B GATA zinc finger domain containing 2B 2 2
MIRT059926 ZDHHC5 zinc finger DHHC-type containing 5 2 2
MIRT061610 BTG2 BTG anti-proliferation factor 2 2 6
MIRT066478 HMGA2 high mobility group AT-hook 2 2 2
MIRT069388 ZFYVE21 zinc finger FYVE-type containing 21 2 2
MIRT069972 GEMIN2 gem nuclear organelle associated protein 2 2 2
MIRT074764 CNEP1R1 CTD nuclear envelope phosphatase 1 regulatory subunit 1 2 2
MIRT076199 GID4 GID complex subunit 4 homolog 2 6
MIRT077512 UBE2Z ubiquitin conjugating enzyme E2 Z 2 4
MIRT077903 TOB1 transducer of ERBB2, 1 2 6
MIRT082250 MED29 mediator complex subunit 29 2 4
MIRT082434 CIC capicua transcriptional repressor 2 6
MIRT082474 PPP1R37 protein phosphatase 1 regulatory subunit 37 2 2
MIRT082778 ZNF264 zinc finger protein 264 2 2
MIRT084533 BCL2L11 BCL2 like 11 2 8
MIRT085309 UBXN4 UBX domain protein 4 2 8
MIRT086365 SSFA2 sperm specific antigen 2 2 8
MIRT087455 NF2 neurofibromin 2 2 2
MIRT088865 FOXN2 forkhead box N2 2 12
MIRT092185 ITPR1 inositol 1,4,5-trisphosphate receptor type 1 2 6
MIRT092326 EDEM1 ER degradation enhancing alpha-mannosidase like protein 1 2 6
MIRT093533 GALNT7 polypeptide N-acetylgalactosaminyltransferase 7 2 6
MIRT096935 PAPD7 poly(A) RNA polymerase D7, non-canonical 2 8
MIRT097026 MAP1B microtubule associated protein 1B 2 4
MIRT099137 MYLIP myosin regulatory light chain interacting protein 2 6
MIRT099905 SOX4 SRY-box 4 2 12
MIRT102289 DNAJB9 DnaJ heat shock protein family (Hsp40) member B9 2 10
MIRT102507 KLHDC10 kelch domain containing 10 2 2
MIRT102891 INSIG1 insulin induced gene 1 2 2
MIRT109188 VMA21 VMA21, vacuolar ATPase assembly factor 2 4
MIRT124567 PRRC2B proline rich coiled-coil 2B 2 2
MIRT135568 SPRYD4 SPRY domain containing 4 2 2
MIRT161135 SLC25A36 solute carrier family 25 member 36 2 6
MIRT163995 KIAA1109 KIAA1109 2 4
MIRT164689 RNF4 ring finger protein 4 2 2
MIRT167705 HIVEP1 human immunodeficiency virus type I enhancer binding protein 1 2 8
MIRT178956 USP28 ubiquitin specific peptidase 28 2 2
MIRT185717 ARNTL2 aryl hydrocarbon receptor nuclear translocator like 2 2 2
MIRT186264 TCEB3 elongin A 2 2
MIRT186537 TWF1 twinfilin actin binding protein 1 2 4
MIRT186628 COX20 COX20, cytochrome c oxidase assembly factor 2 8
MIRT189373 TXLNA taxilin alpha 2 4
MIRT197013 EIF1 eukaryotic translation initiation factor 1 2 10
MIRT206437 YIPF4 Yip1 domain family member 4 2 2
MIRT211228 FGF2 fibroblast growth factor 2 2 10
MIRT214529 C5ORF24 chromosome 5 open reading frame 24 2 2
MIRT216034 IL6ST interleukin 6 signal transducer 2 10
MIRT218084 TULP4 tubby like protein 4 2 2
MIRT242418 CCDC113 coiled-coil domain containing 113 2 2
MIRT243162 SOX11 SRY-box 11 2 2
MIRT250943 CDK5R1 cyclin dependent kinase 5 regulatory subunit 1 2 4
MIRT253350 ZNF417 zinc finger protein 417 2 2
MIRT271968 ARF1 ADP ribosylation factor 1 2 2
MIRT273214 ZNF695 zinc finger protein 695 2 4
MIRT296114 SLC12A5 solute carrier family 12 member 5 2 2
MIRT301711 TEF TEF, PAR bZIP transcription factor 2 2
MIRT316477 ARID1B AT-rich interaction domain 1B 2 6
MIRT322174 CLN8 CLN8, transmembrane ER and ERGIC protein 2 4
MIRT341538 CNIH1 cornichon family AMPA receptor auxiliary protein 1 2 6
MIRT356062 SMARCA5 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 2 2
MIRT443579 PPIC peptidylprolyl isomerase C 2 2
MIRT448825 FKBP1A FK506 binding protein 1A 2 4
MIRT451494 FOPNL FGFR1OP N-terminal like 2 2
MIRT452694 MDM2 MDM2 proto-oncogene 2 2
MIRT453167 CNOT4 CCR4-NOT transcription complex subunit 4 2 6
MIRT454588 SLC33A1 solute carrier family 33 member 1 2 4
MIRT455794 TAF8 TATA-box binding protein associated factor 8 2 4
MIRT456010 CYP2C19 cytochrome P450 family 2 subfamily C member 19 2 2
MIRT456044 KIAA1586 KIAA1586 2 2
MIRT456763 TMEM239 transmembrane protein 239 2 4
MIRT458068 NLRP9 NLR family pyrin domain containing 9 2 2
MIRT459230 MRPS21 mitochondrial ribosomal protein S21 2 2
MIRT459534 MFF mitochondrial fission factor 2 6
MIRT459759 SNRPD1 small nuclear ribonucleoprotein D1 polypeptide 2 2
MIRT460236 TNFRSF13C TNF receptor superfamily member 13C 2 2
MIRT461104 OPA3 OPA3, outer mitochondrial membrane lipid metabolism regulator 2 2
MIRT462924 ZNRF3 zinc and ring finger 3 2 2
MIRT463476 ZC3HAV1L zinc finger CCCH-type containing, antiviral 1 like 2 2
MIRT463516 ZBTB8B zinc finger and BTB domain containing 8B 2 4
MIRT465503 TOR1B torsin family 1 member B 2 2
MIRT469525 RBFOX2 RNA binding protein, fox-1 homolog 2 2 8
MIRT470079 PTGES2 prostaglandin E synthase 2 2 2
MIRT471581 PARD6B par-6 family cell polarity regulator beta 2 2
MIRT473451 MCOLN2 mucolipin 2 2 8
MIRT475882 H3F3C H3 histone family member 3C 2 10
MIRT475915 H3F3B H3 histone family member 3B 2 8
MIRT476195 GOLGA8A golgin A8 family member A 2 10
MIRT476318 GM2A GM2 ganglioside activator 2 2
MIRT476676 FUT11 fucosyltransferase 11 2 10
MIRT478368 DDI2 DNA damage inducible 1 homolog 2 2 2
MIRT479545 CDC5L cell division cycle 5 like 2 2
MIRT481024 BAZ2B bromodomain adjacent to zinc finger domain 2B 2 2
MIRT491009 ATF7IP activating transcription factor 7 interacting protein 2 2
MIRT493168 MKNK2 MAP kinase interacting serine/threonine kinase 2 2 2
MIRT494345 CASKIN1 CASK interacting protein 1 2 2
MIRT499087 ZDHHC21 zinc finger DHHC-type containing 21 2 6
MIRT500029 ABCF2 ATP binding cassette subfamily F member 2 2 8
MIRT501298 RRN3 RRN3 homolog, RNA polymerase I transcription factor 2 4
MIRT503124 BCL11B B-cell CLL/lymphoma 11B 2 8
MIRT503301 GTF2A1 general transcription factor IIA subunit 1 2 6
MIRT504328 ASGR2 asialoglycoprotein receptor 2 2 6
MIRT504471 EID2B EP300 interacting inhibitor of differentiation 2B 2 2
MIRT504655 RPL9 ribosomal protein L9 2 6
MIRT505331 TMF1 TATA element modulatory factor 1 2 8
MIRT505732 SERTAD3 SERTA domain containing 3 2 4
MIRT505827 RSBN1 round spermatid basic protein 1 2 8
MIRT506004 PURG purine rich element binding protein G 2 8
MIRT506308 PCMTD1 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1 2 6
MIRT506806 KLHL15 kelch like family member 15 2 6
MIRT507119 GOLGA8B golgin A8 family member B 2 6
MIRT507353 FAM129A family with sequence similarity 129 member A 2 6
MIRT507591 DDX3X DEAD-box helicase 3, X-linked 2 4
MIRT507674 CPEB4 cytoplasmic polyadenylation element binding protein 4 2 4
MIRT507703 CNOT2 CCR4-NOT transcription complex subunit 2 2 8
MIRT508012 BCAT1 branched chain amino acid transaminase 1 2 4
MIRT510439 ZIC5 Zic family member 5 2 6
MIRT510539 XKR7 XK related 7 2 4
MIRT510600 TPPP tubulin polymerization promoting protein 2 6
MIRT511060 NRAS NRAS proto-oncogene, GTPase 2 4
MIRT511855 GOLGA8J golgin A8 family member J 2 6
MIRT511865 GOLGA8I golgin A8 family member I, pseudogene 1 3
MIRT512570 CTDSPL CTD small phosphatase like 2 2
MIRT512708 ZNF134 zinc finger protein 134 2 6
MIRT513177 MOAP1 modulator of apoptosis 1 2 6
MIRT513783 PAWR pro-apoptotic WT1 regulator 2 6
MIRT515099 IRGQ immunity related GTPase Q 2 2
MIRT515481 INCENP inner centromere protein 2 4
MIRT517416 BMP8A bone morphogenetic protein 8a 2 2
MIRT518754 C1orf35 chromosome 1 open reading frame 35 2 2
MIRT519780 ZNF354B zinc finger protein 354B 2 4
MIRT519865 ZFP62 ZFP62 zinc finger protein 2 6
MIRT520510 TRAM2 translocation associated membrane protein 2 2 6
MIRT521068 SLC25A32 solute carrier family 25 member 32 2 6
MIRT526912 ZNF772 zinc finger protein 772 2 6
MIRT527134 GULP1 GULP, engulfment adaptor PTB domain containing 1 2 2
MIRT527867 SLC39A14 solute carrier family 39 member 14 2 2
MIRT528404 EIF4EBP2 eukaryotic translation initiation factor 4E binding protein 2 2 2
MIRT532956 ZNF24 zinc finger protein 24 2 4
MIRT533021 ZFC3H1 zinc finger C3H1-type containing 2 4
MIRT533191 WASL Wiskott-Aldrich syndrome like 2 6
MIRT534191 SLC7A11 solute carrier family 7 member 11 2 2
MIRT534961 PTAR1 protein prenyltransferase alpha subunit repeat containing 1 2 4
MIRT536396 LCOR ligand dependent nuclear receptor corepressor 2 2
MIRT537046 GRAMD4 GRAM domain containing 4 2 2
MIRT537125 GOLGA3 golgin A3 2 4
MIRT537183 GFPT2 glutamine-fructose-6-phosphate transaminase 2 2 4
MIRT537652 ERGIC2 ERGIC and golgi 2 2 4
MIRT538632 CCSER2 coiled-coil serine rich protein 2 2 4
MIRT539231 ANP32E acidic nuclear phosphoprotein 32 family member E 2 6
MIRT540099 NPY4R neuropeptide Y receptor Y4 2 2
MIRT540998 ZNF460 zinc finger protein 460 2 4
MIRT541468 AURKA aurora kinase A 2 2
MIRT542680 SESN3 sestrin 3 2 2
MIRT542757 PRRG4 proline rich and Gla domain 4 2 2
MIRT542863 NUCKS1 nuclear casein kinase and cyclin dependent kinase substrate 1 2 2
MIRT542925 HOXC8 homeobox C8 2 2
MIRT543747 SZRD1 SUZ RNA binding domain containing 1 2 2
MIRT544404 ZSCAN12 zinc finger and SCAN domain containing 12 2 2
MIRT544583 AP5Z1 adaptor related protein complex 5 zeta 1 subunit 2 4
MIRT544662 MED19 mediator complex subunit 19 2 2
MIRT545251 GTF2E1 general transcription factor IIE subunit 1 2 2
MIRT545261 TRIM36 tripartite motif containing 36 2 4
MIRT545744 UHRF1BP1 UHRF1 binding protein 1 2 2
MIRT545999 WDR81 WD repeat domain 81 2 2
MIRT546038 VPS4B vacuolar protein sorting 4 homolog B 2 2
MIRT547170 PDZD8 PDZ domain containing 8 2 2
MIRT547273 NUFIP2 NUFIP2, FMR1 interacting protein 2 2 2
MIRT547729 KIF5B kinesin family member 5B 2 2
MIRT548127 GATA6 GATA binding protein 6 2 2
MIRT548203 FNIP1 folliculin interacting protein 1 2 2
MIRT548756 CNNM4 cyclin and CBS domain divalent metal cation transport mediator 4 2 2
MIRT549641 ZNF75A zinc finger protein 75a 2 2
MIRT549684 ZNF598 zinc finger protein 598 2 2
MIRT550197 MRO maestro 2 2
MIRT550340 IPP intracisternal A particle-promoted polypeptide 2 2
MIRT550536 MYZAP myocardial zonula adherens protein 2 2
MIRT550975 TOR4A torsin family 4 member A 2 2
MIRT551221 CIDEC cell death inducing DFFA like effector c 2 2
MIRT551355 AGBL5 ATP/GTP binding protein like 5 2 2
MIRT551571 LETM1 leucine zipper and EF-hand containing transmembrane protein 1 2 2
MIRT552277 RAB3D RAB3D, member RAS oncogene family 2 2
MIRT552661 ZADH2 zinc binding alcohol dehydrogenase domain containing 2 2 2
MIRT553081 UCK2 uridine-cytidine kinase 2 2 2
MIRT553753 TBC1D8 TBC1 domain family member 8 2 2
MIRT554030 SPCS3 signal peptidase complex subunit 3 2 2
MIRT554099 SMU1 DNA replication regulator and spliceosomal factor 2 2
MIRT554155 SLX4 SLX4 structure-specific endonuclease subunit 2 2
MIRT554815 REL REL proto-oncogene, NF-kB subunit 2 2
MIRT555522 PMEPA1 prostate transmembrane protein, androgen induced 1 2 2
MIRT555597 PIP5K1C phosphatidylinositol-4-phosphate 5-kinase type 1 gamma 2 2
MIRT555632 PHLPP2 PH domain and leucine rich repeat protein phosphatase 2 2 4
MIRT555679 PGAM4 phosphoglycerate mutase family member 4 2 4
MIRT555827 PAX9 paired box 9 2 2
MIRT555868 PAIP1 poly(A) binding protein interacting protein 1 2 2
MIRT555939 NUP43 nucleoporin 43 2 2
MIRT555994 NFYB nuclear transcription factor Y subunit beta 2 2
MIRT556340 MAP2K4 mitogen-activated protein kinase kinase 4 2 2
MIRT556432 LONRF3 LON peptidase N-terminal domain and ring finger 3 2 2
MIRT556585 LHFPL2 LHFPL tetraspan subfamily member 2 2 4
MIRT556801 KIAA1958 KIAA1958 2 2
MIRT558047 EXOC5 exocyst complex component 5 2 2
MIRT558697 CLTA clathrin light chain A 2 2
MIRT559191 BMPR1A bone morphogenetic protein receptor type 1A 2 4
MIRT559639 AKAP10 A-kinase anchoring protein 10 2 2
MIRT559707 AEN apoptosis enhancing nuclease 2 2
MIRT560673 SRFBP1 serum response factor binding protein 1 2 2
MIRT560990 GPBP1L1 GC-rich promoter binding protein 1 like 1 2 2
MIRT562170 HOXA13 homeobox A13 2 2
MIRT562275 GNAQ G protein subunit alpha q 2 2
MIRT563624 ZNF277 zinc finger protein 277 2 2
MIRT563815 FMN1 formin 1 2 2
MIRT564096 TLR3 toll like receptor 3 2 2
MIRT565320 TMEM41A transmembrane protein 41A 2 2
MIRT565986 RNF44 ring finger protein 44 2 2
MIRT566047 REV3L REV3 like, DNA directed polymerase zeta catalytic subunit 2 2
MIRT568236 C11orf24 chromosome 11 open reading frame 24 2 2
MIRT568310 BAK1 BCL2 antagonist/killer 1 2 2
MIRT572376 ATOX1 antioxidant 1 copper chaperone 2 2
MIRT574822 CPEB3 cytoplasmic polyadenylation element binding protein 3 2 2
MIRT609212 PELP1 proline, glutamate and leucine rich protein 1 2 2
MIRT616217 RBM27 RNA binding motif protein 27 2 2
MIRT629087 FASLG Fas ligand 2 2
MIRT632124 FKBP9 FK506 binding protein 9 2 2
MIRT632576 POLQ DNA polymerase theta 2 2
MIRT634799 ENTHD1 ENTH domain containing 1 2 2
MIRT636553 ESRP1 epithelial splicing regulatory protein 1 2 2
MIRT640977 ORAI2 ORAI calcium release-activated calcium modulator 2 2 2
MIRT653875 SH2B3 SH2B adaptor protein 3 2 2
MIRT655598 OTUD7B OTU deubiquitinase 7B 2 2
MIRT659764 CCDC171 coiled-coil domain containing 171 2 2
MIRT660744 ALG14 ALG14, UDP-N-acetylglucosaminyltransferase subunit 2 2
MIRT681037 AAED1 AhpC/TSA antioxidant enzyme domain containing 1 2 2
MIRT682305 RBM28 RNA binding motif protein 28 2 2
MIRT682573 EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 2 2
MIRT686217 ZNF267 zinc finger protein 267 2 2
MIRT687209 PLXNA3 plexin A3 2 2
MIRT690630 LAX1 lymphocyte transmembrane adaptor 1 2 2
MIRT692419 AGMAT agmatinase 2 2
MIRT694437 MCF2L2 MCF.2 cell line derived transforming sequence-like 2 2 2
MIRT700725 PNO1 partner of NOB1 homolog 2 2
MIRT701549 NARF nuclear prelamin A recognition factor 2 2
MIRT704379 DAND5 DAN domain BMP antagonist family member 5 2 2
MIRT707935 PPP1R3D protein phosphatase 1 regulatory subunit 3D 2 2
MIRT709939 MRPS16 mitochondrial ribosomal protein S16 2 2
MIRT711371 MED7 mediator complex subunit 7 2 2
MIRT712327 PER2 period circadian clock 2 2 2
MIRT714515 SHE Src homology 2 domain containing E 2 2
MIRT715520 G2E3 G2/M-phase specific E3 ubiquitin protein ligase 2 2
MIRT724294 OSMR oncostatin M receptor 2 2
MIRT725358 MUC21 mucin 21, cell surface associated 2 2
MIRT732242 KLF4 Kruppel like factor 4 3 1
MIRT735384 SPAG5 sperm associated antigen 5 3 0
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-367 Medpor NULL NULL Microarray osteoblast-like cells line (MG-63) 18408260 2008 up-regulated
miR-367 Activin A NULL 229455 Quantitative real-time PCR Human embryonic stem (hES) cells 19885849 2010 up-regulated
miR-367 Mistletoe lectin-I NULL NULL Microarray colorectal cancer cells CLY cells 20955366 2011 down-regulated
miR-367 Doxorubicin approved 31703 Quantitative real-time PCR heart 22859947 2012 up-regulated
miR-367 Paclitaxel approved 36314 Microarray Ovarian cancer cell lines 24220856 2014 up-regulated
miR-367 Glucose NULL 5793 Quantitative real-time PCR endothelial cells 24394957 2014 down-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-367 Paclitaxel 36314 NSC125973 approved sensitive cell line (A2780)
hsa-miR-367-3p Doxorubicin 31703 NSC123127 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-367-3p Verapamil 2520 NSC272366 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-367-3p Siop Treatment Protocol sensitive High Nephroblastoma tissue
hsa-miR-367-3p Paclitaxel 36314 NSC125973 approved resistant High Pan-Cancer cell line (NCI-H460, NCI-H522, NCI-H322M, HOP62, A549, EKVX, MALME-3M, NCI-H226, HT-29, HCT-116, SE-620, HCT-15, HCC2998, COLO205, HS-578T, NCI/ADR-RES, OVCAR8, OVCAR4, ACHN, SN-12C, 786-O, CAKI-1, UO-31, TK-10, A498, SK-MEL-28, UACC-257, M14, UACC-62, SK
hsa-miR-367-3p Doxorubicin 31703 NSC123127 approved sensitive High Hepatocellular Carcinoma tissue and cell line (HepG2)
hsa-miR-367-3p Mitoxantrone 4212 NSC279836 approved sensitive High Breast Cancer cell line (MCF-7)
hsa-miR-367-3p Sorafenib 216239 NSC747971 approved sensitive Low Hepatocellular Carcinoma cell line (SKhep1, HA22T)
hsa-miR-367-3p Osimertinib 71496458 NSC779217 approved resistant cell line (HCC827)
hsa-miR-367-3p Vemurafenib 42611257 NSC761431 approved resistant cell line (LM16)
hsa-miR-367-3p Vemurafenib 42611257 NSC761431 approved resistant cell line (LM36)
hsa-miR-367-3p Sunitinib 5329102 NSC750690 approved resistant tissue (CardA)
hsa-miR-367-3p Paclitaxel 36314 NSC125973 approved sensitive cell line (SKOV3)
hsa-miR-367-3p Cisplatin 5460033 NSC119875 approved resistant cell line (IGROV-1)
hsa-miR-367-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)

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