miRTarBase - #MIRT077515


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pre-miRNA Information
pre-miRNA hsa-mir-651   
Genomic Coordinates chrX: 8126965 - 8127061
Synonyms MIRN651, hsa-mir-651, MIR651
Description Homo sapiens miR-651 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-651-3p
Sequence 54| AAAGGAAAGUGUAUCCUAAAAG |75
Evidence Experimental
Experiments Illumina
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 1 X + 8127018 29233923 MiREDiBase
A-to-I 2 X + 8127019 29233923 MiREDiBase
A-to-I 3 X + 8127020 29233923 MiREDiBase
A-to-I 8 X + 8127025 29233923 MiREDiBase
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1432177941 9 dbSNP
rs755244358 11 dbSNP
rs1377072248 15 dbSNP
rs1235303566 17 dbSNP
rs781363578 20 dbSNP
Putative Targets

Gene Information
Gene Symbol UBE2Z   
Synonyms HOYS7, USE1
Description ubiquitin conjugating enzyme E2 Z
Transcript NM_023079   
Expression
Putative miRNA Targets on UBE2Z
3'UTR of UBE2Z
(miRNA target sites are highlighted)		 
>UBE2Z|NM_023079|3'UTR
   1 ACCCTGCTCCCATCTCCCCTTCCCCCACTCAAGAGTCCCAGCAGAATCCCTTCCCCCCACCCCAGGGATGGAGAGGCACT
  81 GTGTATCTCCCTCCAGACTCGAAGTCATCCTGCAAGATGGCAAGAACCAAGCAAGCTCCGATCCCAGGGTGTGGGAGTGG
 161 GGGCCTGTTCCCGGTCTGACCTCCTTGGCACTGGAGCATCTGGGGCTTCGTTCATCCATTCATCCCGTATCAGGGGCCAA
 241 GGTACCTTTACAGGAGCACCTAGAGCGAGGGCCTTTGGCAAAAACAAAACAACCAACACACCTCTCCACAGGGCCAGCTC
 321 CTTAGGGATAAGTGGAAGATGGAAATTGCAATTCCAAGAGGGAGTGTGCCCAAATGATTTATGGGGATACCTGGAAGGGA
 401 GCTTGGGGTGGGGGCTGTCTGTGACACTTAAGCAGTCTGGGTGGTTGTCTATTTGTCTGTCTTCAGTCTTGAAGCAGGGC
 481 TTCCCAATGCCCTTTTCCTCCCTGCCTTCCTTCCCCCATTATTTCCCACAGGCCAGCATAATTTTGTTTTTCCTAATTTA
 561 TAGTCACTGTTCTAGACAGACCAAAGAGAAGGAACAGTGGTGGAGTCTAGGCTGCTGATCAGTAAGCTTTACCTAGCACC
 641 TGAGCACCTTTCTCCCCTCCCCTCTTTCCTCACCCTTTTCTAGATGTAAGACAGAAAGTAAATGTGACTGGGACTTAACC
 721 AAGGTCTTGGTAAAGCCTGCATGGCACCGTAAGAAGCTGAAAATACTGTTTGTTCCCGCAATCACTGATTTGAAAAGTTC
 801 CCAACACAGGCAGCTGCTGTGTATATGGGATTAGAGCCACTACATAGAATAGTCTCTTACAGATTTTCATAAATACTAGT
 881 CACAATAAGGGTATTTTTCTTGGGGGTGGAGTAAGGGGGAGACTGATGCTAGTCCTTGTTGTATTTTGTTGGGCTGTCCT
 961 TGTGTATTTTCACCCCAGCCTGTAGTCCTCCTCACTTCAACCCCAGGGATTTTTGGGGAGCAAGGGTAGCCAATGGCAGA
1041 GGGGGTTGGGGCTGGGACTCTGGAGGCTCCTCCCCTTCTTTCTCTTCCTTCCGCCTCCCCCGTGCCCCCAGCTGCTCTTG
1121 TCACTGTCTCTGATGGGTATTTGCCTGGCTTTGTTGCTTCTCTATCTGTATTTAGCTGCAGTGATCCTTTAGCTGGTTGG
1201 CTCAGAAAAAAAAAAATGTGCTTTAGGTGCCCTGTAATCCTGGGCATCAAGGGAATCCATCCTTCCCCTTTTTGATATGT
1281 TCTCCCCGTACTTCCAGATTTATTGTTATGGCTCCCAGTGGGTATTGGCGATTCTTGTGATGCAGGGCCTCAGTCAGTGT
1361 CCAGCCATGCATAAGGGAGAGGATAGTGTGTACCTGCCCTGCCCTCTGCTATGAAGGTCTCTGCCTTGTGGATCATGGGA
1441 CTCCCCTTGGAGGATCTGTGCAAAGGGGGGCTGGGCACAAAGGAGAATGTCCTATTTGGGAGGGCAGGAAGCAAAGGAAC
1521 TGGACAGGGATTGGTGGGCTTGGGGAACGGAAGTTTATCTTGGATACCCTTGAAGAGGCTGGGTCTCTTCACATGAAGAT
1601 CGAAAAGGGACCCTGCTTCCAATTTCCCTCTTCCATTCCTCGAGCTACTCCAGGGCTTAGAAGAATGCTCTTGGTCTGTG
1681 GGTCCAGTGTTGTCTGTCATCCATTTAAGTGTTCCCACTTTCAAGTGACAATCCTCTCCTTGGCCCTGCCATAGGGCAGA
1761 GCATGTCTGGCATAGCAGCCTGACTTTTATGCCCTAATCTTGAGTTGAGGAAATATATGCACAGGAGTCAAAGAGATGTC
1841 TTTATATCTGACTGTATATAAATGAAGTTTTTTTGTTTTTTTTGTTTTCCTTTTTGGTGCAATAAAGTTTGTTTTGGCAG
1921 AAGGAGAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' gaAAAUCCUAUGUGAAAGGAAa 5'
            |||    | :::||||||| 
Target 5' ttTTT----TTTGTTTTCCTTt 3'
 1876 - 1893 146.00 -8.00
2 
miRNA  3' gaaAAUCCUAUGUGAAAGGAAa 5'
             | |||:|  |:|||:||| 
Target 5' caaTAAGGGT--ATTTTTCTTg 3'
 883 - 902 143.00 -10.00
3 
miRNA  3' gaaaauccUAUGUG-AAAGGAaa 5'
                  ||:| | ||||||  
Target 5' gcttcccaATGCCCTTTTCCTcc 3'
 479 - 501 130.00 -6.60
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30504296 8 COSMIC
COSN30493296 34 COSMIC
COSN31590255 74 COSMIC
COSN20719776 90 COSMIC
COSN31480834 114 COSMIC
COSN19660126 228 COSMIC
COSN21666629 238 COSMIC
COSN31547722 380 COSMIC
COSN20093312 400 COSMIC
COSN30539327 415 COSMIC
COSN5840537 592 COSMIC
COSN8603318 736 COSMIC
COSN17427059 915 COSMIC
COSN27393052 1217 COSMIC
COSN28988544 1217 COSMIC
COSN32063139 1289 COSMIC
COSN31518881 1370 COSMIC
COSN31550703 1387 COSMIC
COSN31577392 1448 COSMIC
COSN31610752 1532 COSMIC
COSN8837905 1549 COSMIC
COSN20114135 1574 COSMIC
COSN31553242 1810 COSMIC
COSN31521849 1875 COSMIC
COSN19658217 1884 COSMIC
rs2088138 228 GWAS
rs1057902 1093 GWAS
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs780694428 2 dbSNP
rs370323738 3 dbSNP
rs1341988774 4 dbSNP
rs1350498988 5 dbSNP
rs747862204 12 dbSNP
rs1278579838 14 dbSNP
rs769238796 14 dbSNP
rs1342769798 15 dbSNP
rs1310580342 16 dbSNP
rs1230720889 18 dbSNP
rs375182716 24 dbSNP
rs752464191 25 dbSNP
rs1046088854 27 dbSNP
rs373393504 31 dbSNP
rs1201204532 32 dbSNP
rs1424865541 33 dbSNP
rs1258509336 36 dbSNP
rs772731933 37 dbSNP
rs1187273543 42 dbSNP
rs955795056 49 dbSNP
rs762880607 53 dbSNP
rs1415711385 57 dbSNP
rs906179137 58 dbSNP
rs758061472 59 dbSNP
rs879203141 63 dbSNP
rs1215162215 64 dbSNP
rs540148072 65 dbSNP
rs1052612318 67 dbSNP
rs1203609997 79 dbSNP
rs559871901 81 dbSNP
rs893520545 85 dbSNP
rs926707887 86 dbSNP
rs974090766 86 dbSNP
rs1428607185 90 dbSNP
rs1344352059 92 dbSNP
rs1318760155 93 dbSNP
rs1429343196 96 dbSNP
rs1415969068 101 dbSNP
rs1475571403 101 dbSNP
rs777646756 102 dbSNP
rs1195368424 108 dbSNP
rs1427318508 114 dbSNP
rs529109663 118 dbSNP
rs1175671009 119 dbSNP
rs558437177 119 dbSNP
rs1429736252 123 dbSNP
rs1467441645 133 dbSNP
rs548771558 136 dbSNP
rs917115571 137 dbSNP
rs562588657 140 dbSNP
rs781158895 141 dbSNP
rs1299443903 144 dbSNP
rs1019644451 151 dbSNP
rs1361207621 156 dbSNP
rs1270492280 163 dbSNP
rs902818810 163 dbSNP
rs965755149 164 dbSNP
rs972718389 165 dbSNP
rs1325450302 168 dbSNP
rs1462204145 170 dbSNP
rs1396741122 173 dbSNP
rs527679814 174 dbSNP
rs1284557484 180 dbSNP
rs1420856310 182 dbSNP
rs952744978 183 dbSNP
rs529682476 188 dbSNP
rs547853159 189 dbSNP
rs996630049 190 dbSNP
rs1237251485 191 dbSNP
rs1192581805 195 dbSNP
rs551393992 204 dbSNP
rs1468666754 209 dbSNP
rs1260540256 210 dbSNP
rs571303708 211 dbSNP
rs534453806 221 dbSNP
rs948027083 227 dbSNP
rs2088138 228 dbSNP
rs1302455715 232 dbSNP
rs891306865 232 dbSNP
rs927692963 235 dbSNP
rs934996559 239 dbSNP
rs1441858380 247 dbSNP
rs1373488490 249 dbSNP
rs1296458921 253 dbSNP
rs371315163 266 dbSNP
rs572097149 266 dbSNP
rs148572493 267 dbSNP
rs893573402 269 dbSNP
rs962972477 286 dbSNP
rs1010590983 291 dbSNP
rs1429836938 302 dbSNP
rs1174677433 309 dbSNP
rs1442726232 317 dbSNP
rs995460855 321 dbSNP
rs1043233130 332 dbSNP
rs1434838401 335 dbSNP
rs1175183580 336 dbSNP
rs1156615864 343 dbSNP
rs1033671290 347 dbSNP
rs1232997447 359 dbSNP
rs1363030379 367 dbSNP
rs1345673887 369 dbSNP
rs748419470 380 dbSNP
rs1234756239 385 dbSNP
rs542960145 400 dbSNP
rs1160124338 403 dbSNP
rs1363164263 409 dbSNP
rs1391089323 410 dbSNP
rs1403861351 411 dbSNP
rs1299998685 416 dbSNP
rs1020287555 420 dbSNP
rs1413421249 420 dbSNP
rs1303236357 426 dbSNP
rs1375386120 431 dbSNP
rs1370309463 442 dbSNP
rs1390191805 448 dbSNP
rs1306710442 452 dbSNP
rs965623245 452 dbSNP
rs1317943234 455 dbSNP
rs1362476107 464 dbSNP
rs1242583977 468 dbSNP
rs1418185534 484 dbSNP
rs556512664 485 dbSNP
rs1408014466 487 dbSNP
rs994588330 499 dbSNP
rs1359018344 502 dbSNP
rs1223226433 503 dbSNP
rs971264628 505 dbSNP
rs1256714161 507 dbSNP
rs977290152 509 dbSNP
rs1025626895 510 dbSNP
rs554890722 519 dbSNP
rs78183148 523 dbSNP
rs772271394 528 dbSNP
rs935931316 535 dbSNP
rs879392472 536 dbSNP
rs1231532363 547 dbSNP
rs754944006 547 dbSNP
rs1249518230 555 dbSNP
rs1398350533 563 dbSNP
rs920949722 573 dbSNP
rs1288681611 583 dbSNP
rs1419523457 589 dbSNP
rs984192965 596 dbSNP
rs932364194 599 dbSNP
rs1161013991 606 dbSNP
rs558485216 634 dbSNP
rs916453123 640 dbSNP
rs969626143 646 dbSNP
rs1473932147 651 dbSNP
rs1416590972 653 dbSNP
rs1188527847 662 dbSNP
rs1425519328 664 dbSNP
rs1382935274 684 dbSNP
rs1259338825 689 dbSNP
rs1204343462 690 dbSNP
rs1423642032 693 dbSNP
rs981929807 695 dbSNP
rs15563 698 dbSNP
rs1212114069 704 dbSNP
rs1004383305 717 dbSNP
rs1294021119 721 dbSNP
rs1351167140 730 dbSNP
rs760982011 736 dbSNP
rs935236006 749 dbSNP
rs1325217189 750 dbSNP
rs752445256 767 dbSNP
rs1383123955 768 dbSNP
rs1037196207 769 dbSNP
rs1298177560 773 dbSNP
rs1322112773 776 dbSNP
rs540109810 778 dbSNP
rs995738773 779 dbSNP
rs771444084 796 dbSNP
rs1165037560 809 dbSNP
rs1459325974 814 dbSNP
rs1033619209 835 dbSNP
rs1192461526 837 dbSNP
rs959415992 840 dbSNP
rs1249710247 845 dbSNP
rs1247014408 846 dbSNP
rs1191945520 853 dbSNP
rs1292082805 855 dbSNP
rs550495041 858 dbSNP
rs1211722241 859 dbSNP
rs1273830495 859 dbSNP
rs553667689 860 dbSNP
rs1305876841 861 dbSNP
rs1251233918 869 dbSNP
rs573888085 872 dbSNP
rs1250749155 884 dbSNP
rs3744611 886 dbSNP
rs1344720033 892 dbSNP
rs1025063078 894 dbSNP
rs1438199336 901 dbSNP
rs946501224 907 dbSNP
rs967229362 913 dbSNP
rs35412283 920 dbSNP
rs1388003181 923 dbSNP
rs1393763440 930 dbSNP
rs1241064989 936 dbSNP
rs977237732 944 dbSNP
rs777332932 949 dbSNP
rs759111902 955 dbSNP
rs764843058 956 dbSNP
rs114544818 957 dbSNP
rs990080055 960 dbSNP
rs1436133800 961 dbSNP
rs920894277 963 dbSNP
rs1169154772 975 dbSNP
rs1344964011 983 dbSNP
rs551250375 986 dbSNP
rs562587672 989 dbSNP
rs1349132043 991 dbSNP
rs1467668539 991 dbSNP
rs1335080290 999 dbSNP
rs1275058243 1005 dbSNP
rs1057897 1014 dbSNP
rs912307126 1017 dbSNP
rs1453611260 1026 dbSNP
rs780199445 1034 dbSNP
rs939795734 1038 dbSNP
rs1286241277 1042 dbSNP
rs1372338443 1043 dbSNP
rs1037144206 1045 dbSNP
rs55685312 1047 dbSNP
rs1359939120 1048 dbSNP
rs1425671248 1051 dbSNP
rs1174503806 1054 dbSNP
rs1468827551 1056 dbSNP
rs1304298462 1061 dbSNP
rs28384242 1063 dbSNP
rs898687057 1067 dbSNP
rs1183003447 1068 dbSNP
rs1214000677 1071 dbSNP
rs545134568 1073 dbSNP
rs1256019133 1075 dbSNP
rs1486188094 1079 dbSNP
rs931538900 1079 dbSNP
rs1281215238 1083 dbSNP
rs1057902 1093 dbSNP
rs895101744 1094 dbSNP
rs1200507253 1095 dbSNP
rs1278377099 1096 dbSNP
rs1260991691 1100 dbSNP
rs888442786 1102 dbSNP
rs1210375314 1103 dbSNP
rs1212861353 1105 dbSNP
rs1238792151 1106 dbSNP
rs1005680990 1108 dbSNP
rs763695949 1112 dbSNP
rs527304002 1115 dbSNP
rs1399116302 1116 dbSNP
rs902576602 1118 dbSNP
rs1023730283 1137 dbSNP
rs1473604187 1140 dbSNP
rs1415830109 1146 dbSNP
rs999627356 1154 dbSNP
rs1473428932 1157 dbSNP
rs969467435 1159 dbSNP
rs957200164 1165 dbSNP
rs1419636069 1180 dbSNP
rs1283107760 1182 dbSNP
rs183523260 1189 dbSNP
rs1209019992 1198 dbSNP
rs1330567668 1200 dbSNP
rs751349199 1201 dbSNP
rs1028237220 1204 dbSNP
rs1325699418 1206 dbSNP
rs201929916 1206 dbSNP
rs954134729 1206 dbSNP
rs986471283 1206 dbSNP
rs912238268 1207 dbSNP
rs982370083 1211 dbSNP
rs1164327835 1212 dbSNP
rs1174954217 1218 dbSNP
rs757060295 1225 dbSNP
rs1185349968 1228 dbSNP
rs567930192 1234 dbSNP
rs988008406 1237 dbSNP
rs1250535452 1251 dbSNP
rs1220191685 1255 dbSNP
rs1336571732 1256 dbSNP
rs530352744 1263 dbSNP
rs946386861 1266 dbSNP
rs1298100493 1267 dbSNP
rs1289501796 1268 dbSNP
rs1342496641 1269 dbSNP
rs1220388791 1275 dbSNP
rs985725201 1276 dbSNP
rs1322752876 1278 dbSNP
rs1219526885 1280 dbSNP
rs550343444 1281 dbSNP
rs1444870086 1283 dbSNP
rs113236693 1284 dbSNP
rs1437269536 1288 dbSNP
rs866794801 1289 dbSNP
rs1168914036 1292 dbSNP
rs7221215 1299 dbSNP
rs538702827 1301 dbSNP
rs1391119513 1303 dbSNP
rs1046366857 1310 dbSNP
rs1250747293 1316 dbSNP
rs999576691 1316 dbSNP
rs901328801 1326 dbSNP
rs558651244 1331 dbSNP
rs1268727788 1338 dbSNP
rs930246788 1341 dbSNP
rs1202302492 1348 dbSNP
rs1032429906 1350 dbSNP
rs1478645582 1350 dbSNP
rs1230334485 1352 dbSNP
rs1345542592 1356 dbSNP
rs1308595486 1365 dbSNP
rs1300827501 1372 dbSNP
rs1174628020 1373 dbSNP
rs1220078642 1374 dbSNP
rs867349933 1376 dbSNP
rs866183830 1385 dbSNP
rs1160195986 1388 dbSNP
rs1362527997 1392 dbSNP
rs1310458542 1394 dbSNP
rs1433229944 1396 dbSNP
rs1394906111 1397 dbSNP
rs1174874004 1398 dbSNP
rs1028604104 1402 dbSNP
rs192998454 1403 dbSNP
rs1302637555 1404 dbSNP
rs1174985119 1405 dbSNP
rs1472018663 1412 dbSNP
rs1252436166 1420 dbSNP
rs1207273844 1426 dbSNP
rs1484551828 1434 dbSNP
rs781106346 1438 dbSNP
rs1211026993 1440 dbSNP
rs1005565173 1443 dbSNP
rs1314180464 1445 dbSNP
rs1437128644 1465 dbSNP
rs1304882717 1466 dbSNP
rs534685601 1467 dbSNP
rs1413516040 1469 dbSNP
rs1207074478 1470 dbSNP
rs1375174007 1479 dbSNP
rs1023608940 1493 dbSNP
rs905296556 1494 dbSNP
rs750362080 1495 dbSNP
rs1466177782 1509 dbSNP
rs1003615964 1511 dbSNP
rs1276366981 1528 dbSNP
rs375342301 1529 dbSNP
rs1471967146 1539 dbSNP
rs1348322207 1548 dbSNP
rs1474198052 1549 dbSNP
rs1479812743 1549 dbSNP
rs1255147872 1550 dbSNP
rs1182239036 1552 dbSNP
rs1484152141 1554 dbSNP
rs754988922 1554 dbSNP
rs1035296608 1558 dbSNP
rs1222844260 1569 dbSNP
rs144120233 1571 dbSNP
rs1255571022 1572 dbSNP
rs370886107 1572 dbSNP
rs113522189 1575 dbSNP
rs113446783 1578 dbSNP
rs919676302 1581 dbSNP
rs931100399 1586 dbSNP
rs956562579 1589 dbSNP
rs185251725 1591 dbSNP
rs1219534576 1594 dbSNP
rs990984153 1602 dbSNP
rs145544916 1603 dbSNP
rs542597475 1615 dbSNP
rs1360378778 1626 dbSNP
rs1201698327 1628 dbSNP
rs1022175285 1634 dbSNP
rs967909209 1636 dbSNP
rs1231527599 1642 dbSNP
rs1456411227 1661 dbSNP
rs147694058 1663 dbSNP
rs778981845 1666 dbSNP
rs1160762730 1668 dbSNP
rs985777672 1669 dbSNP
rs1179671698 1670 dbSNP
rs910201560 1671 dbSNP
rs576160999 1674 dbSNP
rs1425311036 1675 dbSNP
rs772310523 1682 dbSNP
rs565856862 1711 dbSNP
rs3205390 1718 dbSNP
rs551454124 1732 dbSNP
rs1188122608 1735 dbSNP
rs930132323 1740 dbSNP
rs1423013897 1743 dbSNP
rs935316196 1744 dbSNP
rs1162961008 1760 dbSNP
rs1266526834 1762 dbSNP
rs1391600770 1764 dbSNP
rs1306091343 1765 dbSNP
rs777908726 1768 dbSNP
rs1297358134 1774 dbSNP
rs1433827166 1783 dbSNP
rs1365479696 1795 dbSNP
rs1192571280 1800 dbSNP
rs1405845102 1801 dbSNP
rs1047229793 1807 dbSNP
rs910151356 1809 dbSNP
rs941572710 1811 dbSNP
rs1371079903 1817 dbSNP
rs1441136304 1827 dbSNP
rs1167736393 1828 dbSNP
rs893883757 1830 dbSNP
rs1045498604 1832 dbSNP
rs1049556817 1835 dbSNP
rs1378604001 1844 dbSNP
rs905182823 1845 dbSNP
rs1243378339 1847 dbSNP
rs889631258 1847 dbSNP
rs189626966 1855 dbSNP
rs1479951873 1859 dbSNP
rs1019954535 1868 dbSNP
rs1229594676 1868 dbSNP
rs1274285679 1868 dbSNP
rs1056553110 1872 dbSNP
rs753542757 1872 dbSNP
rs993788008 1873 dbSNP
rs1329961704 1875 dbSNP
rs1307413686 1876 dbSNP
rs1343147215 1876 dbSNP
rs1372225245 1876 dbSNP
rs1430149651 1876 dbSNP
rs564987923 1876 dbSNP
rs71369239 1876 dbSNP
rs952439833 1877 dbSNP
rs1477837775 1878 dbSNP
rs566448111 1879 dbSNP
rs527415185 1880 dbSNP
rs990986718 1881 dbSNP
rs1201097464 1884 dbSNP
rs200294094 1885 dbSNP
rs1009367560 1889 dbSNP
rs1271434214 1889 dbSNP
rs11557620 1890 dbSNP
rs1022060735 1895 dbSNP
rs916717976 1897 dbSNP
rs967961158 1903 dbSNP
rs1240443570 1904 dbSNP
rs1278674520 1905 dbSNP
rs1198322355 1907 dbSNP
rs1442981257 1919 dbSNP
rs3179960 1921 dbSNP
rs747389446 1922 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Disease 65264.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM714644. RNA binding protein: AGO2. Condition:completeT1 "PAR-CLIP data was present in GSM714645. RNA binding protein: AGO2. Condition:completeT1 ...

- Kishore S; Jaskiewicz L; Burger L; Hausser et al., 2011, Nature methods.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' gaaaauccuauguGAAAGGAAa 5'
                       :||||||| 
Target 5' -------------UUUUCCUUu 3'
 		1 - 9
Article - Kishore S; Jaskiewicz L; Burger L; Hausser et al.
- Nature methods, 2011
Cross-linking and immunoprecipitation (CLIP) is increasingly used to map transcriptome-wide binding sites of RNA-binding proteins. We developed a method for CLIP data analysis, and applied it to compare CLIP with photoactivatable ribonucleoside-enhanced CLIP (PAR-CLIP) and to uncover how differences in cross-linking and ribonuclease digestion affect the identified sites. We found only small differences in accuracies of these methods in identifying binding sites of HuR, which binds low-complexity sequences, and Argonaute 2, which has a complex binding specificity. We found that cross-link-induced mutations led to single-nucleotide resolution for both PAR-CLIP and CLIP. Our results confirm the expectation from original CLIP publications that RNA-binding proteins do not protect their binding sites sufficiently under the denaturing conditions used during the CLIP procedure, and we show that extensive digestion with sequence-specific RNases strongly biases the recovered binding sites. This bias can be substantially reduced by milder nuclease digestion conditions.
LinkOut: [PMID: 21572407]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions MCF7
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in SRR1045082. RNA binding protein: AGO2. Condition:Untreated ...

- Farazi TA; Ten Hoeve JJ; Brown M; et al., 2014, Genome biology.

Article - Farazi TA; Ten Hoeve JJ; Brown M; et al.
- Genome biology, 2014
BACKGROUND: Various microRNAs (miRNAs) are up- or downregulated in tumors. However, the repression of cognate miRNA targets responsible for the phenotypic effects of this dysregulation in patients remains largely unexplored. To define miRNA targets and associated pathways, together with their relationship to outcome in breast cancer, we integrated patient-paired miRNA-mRNA expression data with a set of validated miRNA targets and pathway inference. RESULTS: To generate a biochemically-validated set of miRNA-binding sites, we performed argonaute-2 photoactivatable-ribonucleoside-enhanced crosslinking and immunoprecipitation (AGO2-PAR-CLIP) in MCF7 cells. We then defined putative miRNA-target interactions using a computational model, which ranked and selected additional TargetScan-predicted interactions based on features of our AGO2-PAR-CLIP binding-site data. We subselected modeled interactions according to the abundance of their constituent miRNA and mRNA transcripts in tumors, and we took advantage of the variability of miRNA expression within molecular subtypes to detect miRNA repression. Interestingly, our data suggest that miRNA families control subtype-specific pathways; for example, miR-17, miR-19a, miR-25, and miR-200b show high miRNA regulatory activity in the triple-negative, basal-like subtype, whereas miR-22 and miR-24 do so in the HER2 subtype. An independent dataset validated our findings for miR-17 and miR-25, and showed a correlation between the expression levels of miR-182 targets and overall patient survival. Pathway analysis associated miR-17, miR-19a, and miR-200b with leukocyte transendothelial migration. CONCLUSIONS: We combined PAR-CLIP data with patient expression data to predict regulatory miRNAs, revealing potential therapeutic targets and prognostic markers in breast cancer.
LinkOut: [PMID: 24398324]
CLIP-seq Support 1 for dataset GSM714644
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / completeT1, repA
Location of target site ENST00000360943.5 | 3UTR | UUUGUUUUCCUUUUUGGUGCAAUAAAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 21572407 / GSE28865
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM714645
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / completeT1, repB
Location of target site ENST00000360943.5 | 3UTR | UUUUCCUUUUUGGUGCAAUAAAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 21572407 / GSE28865
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset SRR1045082
Method / RBP PAR-CLIP / AGO2
Cell line / Condition MCF7 / Untreated
Location of target site ENST00000360943.5 | 3UTR | UUUUCCUUUUUGGUGCAAUAAAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 24398324 / SRX388831
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
194 hsa-miR-651-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT056057 COMMD3 COMM domain containing 3 2 6
MIRT063483 SKI SKI proto-oncogene 2 2
MIRT069866 SRP54 signal recognition particle 54 2 2
MIRT076184 GID4 GID complex subunit 4 homolog 2 4
MIRT076517 TNFAIP1 TNF alpha induced protein 1 2 2
MIRT077515 UBE2Z ubiquitin conjugating enzyme E2 Z 2 4
MIRT085102 IFNAR2 interferon alpha and beta receptor subunit 2 2 6
MIRT088657 EML4 echinoderm microtubule associated protein like 4 2 2
MIRT094746 SNX24 sorting nexin 24 2 2
MIRT113261 TMBIM6 transmembrane BAX inhibitor motif containing 6 2 4
MIRT121612 LMNB1 lamin B1 2 2
MIRT144320 NFAT5 nuclear factor of activated T-cells 5 2 6
MIRT145283 NUFIP2 NUFIP2, FMR1 interacting protein 2 2 2
MIRT164579 CASP3 caspase 3 2 2
MIRT180611 CRY2 cryptochrome circadian clock 2 2 2
MIRT188276 RAP1B RAP1B, member of RAS oncogene family 2 2
MIRT205619 PTMA prothymosin, alpha 2 2
MIRT213347 TADA2B transcriptional adaptor 2B 2 2
MIRT214460 C5ORF24 chromosome 5 open reading frame 24 2 2
MIRT220426 MKLN1 muskelin 1 2 2
MIRT222680 EIF4H eukaryotic translation initiation factor 4H 2 6
MIRT233424 BTF3L4 basic transcription factor 3 like 4 2 2
MIRT233779 MAZ MYC associated zinc finger protein 2 2
MIRT239476 TMEM106B transmembrane protein 106B 2 2
MIRT241597 AMOTL1 angiomotin like 1 2 2
MIRT242678 TPM4 tropomyosin 4 2 2
MIRT261814 BUB3 BUB3, mitotic checkpoint protein 2 4
MIRT265276 RRAS2 RAS related 2 2 4
MIRT270217 ATP2A2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 2 4
MIRT273432 DAZAP2 DAZ associated protein 2 2 6
MIRT285120 TERF2IP TERF2 interacting protein 2 6
MIRT286011 TVP23B trans-golgi network vesicle protein 23 homolog B 2 2
MIRT288782 KCNJ2 potassium voltage-gated channel subfamily J member 2 2 2
MIRT302480 CLIP4 CAP-Gly domain containing linker protein family member 4 2 2
MIRT302831 SOCS5 suppressor of cytokine signaling 5 2 2
MIRT307147 CTDSPL CTD small phosphatase like 2 4
MIRT312581 G3BP1 G3BP stress granule assembly factor 1 2 4
MIRT315678 NUS1 NUS1 dehydrodolichyl diphosphate synthase subunit 2 8
MIRT317806 GLO1 glyoxalase I 2 2
MIRT327636 ZXDB zinc finger, X-linked, duplicated B 2 6
MIRT333613 CTNND1 catenin delta 1 2 2
MIRT333717 FEN1 flap structure-specific endonuclease 1 2 2
MIRT355451 TRIM71 tripartite motif containing 71 2 2
MIRT362767 RAC1 Rac family small GTPase 1 2 4
MIRT366928 OGT O-linked N-acetylglucosamine (GlcNAc) transferase 2 2
MIRT379487 CD274 CD274 molecule 2 2
MIRT409156 FZD1 frizzled class receptor 1 2 2
MIRT441667 SEPT3 septin 3 2 2
MIRT441823 HS2ST1 heparan sulfate 2-O-sulfotransferase 1 2 4
MIRT443933 ZNF418 zinc finger protein 418 2 2
MIRT444572 UNC5C unc-5 netrin receptor C 2 2
MIRT445971 IKZF5 IKAROS family zinc finger 5 2 2
MIRT446108 TSC22D2 TSC22 domain family member 2 2 2
MIRT446224 SLC25A44 solute carrier family 25 member 44 2 2
MIRT446659 MINA ribosomal oxygenase 2 2 2
MIRT447016 RSF1 remodeling and spacing factor 1 2 2
MIRT448136 CCDC80 coiled-coil domain containing 80 2 2
MIRT448894 CNNM3 cyclin and CBS domain divalent metal cation transport mediator 3 2 2
MIRT449031 ADRB1 adrenoceptor beta 1 2 2
MIRT450646 ZMYM2 zinc finger MYM-type containing 2 2 2
MIRT453947 XRCC6 X-ray repair cross complementing 6 2 6
MIRT454021 ALKBH5 alkB homolog 5, RNA demethylase 2 2
MIRT455880 SLC35C2 solute carrier family 35 member C2 2 2
MIRT458962 SAMD4B sterile alpha motif domain containing 4B 2 2
MIRT458975 ZNF436 zinc finger protein 436 2 2
MIRT463642 YY1 YY1 transcription factor 2 8
MIRT464573 UBQLN4 ubiquilin 4 2 2
MIRT464845 RPS27A ribosomal protein S27a 2 12
MIRT465761 TMPPE transmembrane protein with metallophosphoesterase domain 2 8
MIRT465897 TMEM43 transmembrane protein 43 2 2
MIRT470654 POM121C POM121 transmembrane nucleoporin C 2 2
MIRT471916 NSUN4 NOP2/Sun RNA methyltransferase family member 4 2 2
MIRT473395 MBD4 methyl-CpG binding domain 4, DNA glycosylase 2 6
MIRT473921 LYSMD3 LysM domain containing 3 2 4
MIRT474050 LONRF1 LON peptidase N-terminal domain and ring finger 1 2 2
MIRT474857 KHSRP KH-type splicing regulatory protein 2 2
MIRT474867 KDM5B lysine demethylase 5B 2 2
MIRT475271 IGDCC4 immunoglobulin superfamily DCC subclass member 4 2 2
MIRT476927 FBLIM1 filamin binding LIM protein 1 2 4
MIRT477435 EMP1 epithelial membrane protein 1 2 2
MIRT478409 DCAF8 DDB1 and CUL4 associated factor 8 2 2
MIRT479138 CNBP CCHC-type zinc finger nucleic acid binding protein 2 4
MIRT479331 CERS2 ceramide synthase 2 2 2
MIRT479417 CDKN1B cyclin dependent kinase inhibitor 1B 2 4
MIRT479615 CDC25A cell division cycle 25A 2 2
MIRT480063 CAND1 cullin associated and neddylation dissociated 1 2 2
MIRT481695 AR androgen receptor 2 2
MIRT481831 AP2M1 adaptor related protein complex 2 mu 1 subunit 2 2
MIRT488177 PRRC2B proline rich coiled-coil 2B 2 2
MIRT493104 MKNK2 MAP kinase interacting serine/threonine kinase 2 2 4
MIRT493339 LAPTM4A lysosomal protein transmembrane 4 alpha 2 12
MIRT494196 CNOT6L CCR4-NOT transcription complex subunit 6 like 2 2
MIRT496902 LGI3 leucine rich repeat LGI family member 3 2 2
MIRT497755 OXGR1 oxoglutarate receptor 1 2 2
MIRT498436 EHD4 EH domain containing 4 2 2
MIRT498677 SOD2 superoxide dismutase 2 2 4
MIRT498803 MDM2 MDM2 proto-oncogene 2 4
MIRT500531 YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta 2 6
MIRT501562 POC1B-GALNT4 POC1B-GALNT4 readthrough 2 2
MIRT502426 GALNT4 polypeptide N-acetylgalactosaminyltransferase 4 2 2
MIRT502925 CDC42SE1 CDC42 small effector 1 2 4
MIRT503060 CAB39 calcium binding protein 39 2 2
MIRT503160 ANKRD11 ankyrin repeat domain 11 2 8
MIRT503963 ZNF180 zinc finger protein 180 2 6
MIRT504001 NHS NHS actin remodeling regulator 2 2
MIRT504404 CSDE1 cold shock domain containing E1 2 6
MIRT505057 ZNF202 zinc finger protein 202 2 6
MIRT505698 SESN3 sestrin 3 2 4
MIRT506962 HOXA10 homeobox A10 2 4
MIRT510335 ZNFX1 zinc finger NFX1-type containing 1 2 4
MIRT510754 SLC7A1 solute carrier family 7 member 1 2 2
MIRT511419 HSPA13 heat shock protein family A (Hsp70) member 13 2 4
MIRT512116 CREBZF CREB/ATF bZIP transcription factor 2 2
MIRT512470 CCDC149 coiled-coil domain containing 149 2 2
MIRT512621 PUM1 pumilio RNA binding family member 1 2 6
MIRT513170 TVP23A trans-golgi network vesicle protein 23 homolog A 2 2
MIRT517532 ITM2C integral membrane protein 2C 2 6
MIRT518414 SSU72 SSU72 homolog, RNA polymerase II CTD phosphatase 2 4
MIRT521719 PPP3R1 protein phosphatase 3 regulatory subunit B, alpha 2 4
MIRT524839 ARPP19 cAMP regulated phosphoprotein 19 2 2
MIRT525537 FSIP2 fibrous sheath interacting protein 2 2 2
MIRT528986 HHLA3 HERV-H LTR-associating 3 2 2
MIRT529250 TRIM4 tripartite motif containing 4 2 4
MIRT531378 ARL11 ADP ribosylation factor like GTPase 11 2 2
MIRT534284 SLC12A7 solute carrier family 12 member 7 2 2
MIRT536160 MAP3K9 mitogen-activated protein kinase kinase kinase 9 2 2
MIRT536192 MAML3 mastermind like transcriptional coactivator 3 2 2
MIRT537123 GOLGA3 golgin A3 2 4
MIRT537415 FBXO47 F-box protein 47 2 2
MIRT538968 BLCAP bladder cancer associated protein 2 2
MIRT544316 TAB2 TGF-beta activated kinase 1/MAP3K7 binding protein 2 2 2
MIRT545502 CORO1C coronin 1C 2 2
MIRT545967 YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta 2 2
MIRT546842 RAB4A RAB4A, member RAS oncogene family 2 2
MIRT548510 DYNC1LI2 dynein cytoplasmic 1 light intermediate chain 2 2 2
MIRT549273 ASH1L ASH1 like histone lysine methyltransferase 2 2
MIRT549297 ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 2 4
MIRT549383 AMOT angiomotin 2 2
MIRT550090 TRAPPC2 trafficking protein particle complex 2 2 2
MIRT550434 ORC4 origin recognition complex subunit 4 2 4
MIRT551622 ZNF267 zinc finger protein 267 2 2
MIRT553262 TVP23C trans-golgi network vesicle protein 23 homolog C 2 2
MIRT554047 SOX6 SRY-box 6 2 2
MIRT554401 SERP1 stress associated endoplasmic reticulum protein 1 2 2
MIRT557452 GTPBP2 GTP binding protein 2 2 2
MIRT557860 FGFR1OP FGFR1 oncogene partner 2 4
MIRT560180 COA1 cytochrome c oxidase assembly factor 1 homolog 2 2
MIRT560271 SF1 splicing factor 1 2 2
MIRT560758 ARMC10 armadillo repeat containing 10 2 2
MIRT561014 PDPK1 3-phosphoinositide dependent protein kinase 1 2 2
MIRT561139 MRPL36 mitochondrial ribosomal protein L36 2 2
MIRT561550 SLMO2 PRELI domain containing 3B 2 2
MIRT562182 HNRNPF heterogeneous nuclear ribonucleoprotein F 2 2
MIRT564577 ZXDA zinc finger, X-linked, duplicated A 2 2
MIRT564955 XKR7 XK related 7 2 2
MIRT565363 TMCC1 transmembrane and coiled-coil domain family 1 2 2
MIRT566932 LIN28B lin-28 homolog B 2 2
MIRT567348 H3F3B H3 histone family member 3B 2 2
MIRT567884 CTDNEP1 CTD nuclear envelope phosphatase 1 2 2
MIRT571234 SYT9 synaptotagmin 9 2 2
MIRT574176 FTH1 ferritin heavy chain 1 2 2
MIRT574306 CMTM6 CKLF like MARVEL transmembrane domain containing 6 2 2
MIRT611663 ZYG11B zyg-11 family member B, cell cycle regulator 2 2
MIRT619654 COX19 COX19, cytochrome c oxidase assembly factor 2 2
MIRT621671 UBE4B ubiquitination factor E4B 2 2
MIRT621847 TFCP2 transcription factor CP2 2 2
MIRT623289 MAX MYC associated factor X 2 2
MIRT624890 AAGAB alpha and gamma adaptin binding protein 2 2
MIRT636209 SPATA13 spermatogenesis associated 13 2 2
MIRT636230 SLC44A1 solute carrier family 44 member 1 2 2
MIRT636306 PSMB5 proteasome subunit beta 5 2 2
MIRT640845 CHRDL1 chordin like 1 2 2
MIRT641052 PTPRB protein tyrosine phosphatase, receptor type B 2 2
MIRT648290 TRAPPC2L trafficking protein particle complex 2 like 2 2
MIRT650607 HSD3B1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 2 2
MIRT653900 SETBP1 SET binding protein 1 2 2
MIRT657869 GJD2 gap junction protein delta 2 2 2
MIRT660711 AMER2 APC membrane recruitment protein 2 2 2
MIRT664832 GALNT5 polypeptide N-acetylgalactosaminyltransferase 5 2 2
MIRT682852 DNAJC28 DnaJ heat shock protein family (Hsp40) member C28 2 2
MIRT692494 SPIN4 spindlin family member 4 2 2
MIRT700789 PIM1 Pim-1 proto-oncogene, serine/threonine kinase 2 2
MIRT702922 CRAMP1L cramped chromatin regulator homolog 1 2 2
MIRT704850 CD55 CD55 molecule (Cromer blood group) 2 2
MIRT705698 ANKRD13A ankyrin repeat domain 13A 2 2
MIRT712969 SPAG16 sperm associated antigen 16 2 2
MIRT715621 KCNJ6 potassium voltage-gated channel subfamily J member 6 2 2
MIRT716831 PSME4 proteasome activator subunit 4 2 2
MIRT720368 ZBTB8B zinc finger and BTB domain containing 8B 2 2
MIRT722012 TAF2 TATA-box binding protein associated factor 2 2 2
MIRT722860 CREB5 cAMP responsive element binding protein 5 2 2
MIRT722958 TSPAN1 tetraspanin 1 2 2
MIRT724631 CHSY1 chondroitin sulfate synthase 1 2 2
MIRT734801 EPHA7 EPH receptor A7 1 0
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-651 Atorvastatin approved 60823 Microarray PC3 prostate cancer cells 23936432 2013 down-regualted
miR-651 Glucose NULL 5793 Quantitative real-time PCR endothelial cells 24394957 2014 down-regulated
miR-651 Diethylstilbestrol approved 448537 Microarray mammosphere-derived epithelial cells (MDEC) 19549897 2009 up-regulated
miR-651 Trichostatin A (TSA) NULL 444732 Microarray apoptosis-resistant breast cancer cells 21971930 2011 down-regulated
miR-651 5-aza-2'-deoxycytidine (5-Aza-CdR) approved 451668 Microarray breast cancer HB2 22076154 2011 down-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-651 Cisplatin 5460033 NSC119875 approved sensitive cell line (A2780)
hsa-miR-651-3p Cisplatin 5460033 NSC119875 approved sensitive Low Hepatocellular Carcinoma cell line (HepG2, Hub7)
hsa-miR-651-3p Osimertinib 71496458 NSC779217 approved resistant cell line (PC9)
hsa-miR-651-3p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)

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