miRTarBase - #MIRT078060


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pre-miRNA Information
pre-miRNA hsa-mir-4446   
Genomic Coordinates chr3: 113594876 - 113594942
Description Homo sapiens miR-4446 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4446-5p
Sequence 8| AUUUCCCUGCCAUUCCCUUGGC |29
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1356015605 6 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol PCTP   
Synonyms PC-TP, STARD2
Description phosphatidylcholine transfer protein
Transcript NM_001102402   
Other Transcripts NM_021213   
Expression
Putative miRNA Targets on PCTP
3'UTR of PCTP
(miRNA target sites are highlighted)		 
>PCTP|NM_001102402|3'UTR
   1 GAAAGAGAACTGGGAACATTGCATCCATGGGTTGATGTCTCTGGAAGTGCAACCACCCAATGTCTCTGGAAGTGCCACCT
  81 GGAAGTGCCACCTGGAAGTGTCTCTGGAAGAGCACCCACCACTGTTCAGCCTTCCCCTGCTGTTTCTGTCTTCAGAGGCC
 161 TACACACTACCACATCCTTTCTAAGCATGTTTGCCTGACATCCAGCTCACTCGTCTGCTTCCTTTCTCGCTCCCCCCATC
 241 CTGGGCTGGGCTGCCTTCTTCTACAGTTCAATATGGGGCAGACTAGGGAAACCTTTGCTTGCTTACTATTAGGAGGGGAA
 321 GTCTTCAGTAGGGAACACGATCATTCCATTGTGCAATTTTACGGGGATGGGTGGGCGGAGGGACACAACAAAATTTAAGA
 401 ATGACTATTTGGGCGGGCTGGCTCTTTTGCAGCTTGTGATTTCTTCCAGCTTGGGAGGGGCTGCTGGAAGTGGCATTTCG
 481 TTCAGAGCTGACTTTCAGTGCACCCAAACTGGATGACGTGCCAATGTCCATTTGCCTTATGCTTTGTGGAGCTGATTAGG
 561 CTGGGATTTGAGGTGATAATCCAGTAAGTCTTTCCTCGTTCCTACTTGTGGAGGATCAGTAGCTGTTATGATGCCAGACC
 641 ATTTGGAGAAGTATCAGAGGCCTGACCGGACACATAATATGACAACCACATTTTTCCTCATCATCCATGAGGAAATGGAT
 721 GATTTCTCTTTTCCATATGTCACTGGGGGAAAGGCTGCCTGTACCTCTCAAGCTTTGCATTTTACTGGAAACTGAGGCGT
 801 CAAGATGGCTGTGGCAGCTAGCAAAAGCAAAGATGCTTTGTGCATAGCCTTGTGAAAAAGTATCTTTCTATGCAATAAGA
 881 TGAATTTTCCTCCCAGAATATTTAGAAATGTAGAAGGGATAACAGTTCACAGCCAGGTAAAATTTAACTGGTGGCTTAAT
 961 GACTCTGCACCTTTTTCTCAGGAATTCTGCCTAAGTTGTCTGCCTTTTCTACCACCAAAAAGACTTTTAGTTTTCTATGC
1041 TTTCTCCTGAATTTTGGTAGGGTAAGGTATTTCTATGTCAAAGGCACAGCCTTGATGATCTCAGGGAAAAATTTTAATCA
1121 CTGTGTATAATGATACTGAACCTTGATTAATAACAGAAATTCAGGATGTAAAGCCACAGAATGGGATTTATTAATGTGGG
1201 ATACCTCAGACTGTTTGTTTTCTTTCTGGGAAGAAAAGTGTGTTCTATAATGAATAAATATAGAGTGGTTTTTACTTGTC
1281 CTGTGTAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' cgGUUCCCUUACCG-UCCCUUUa 5'
            :| |||:  | | ||||||| 
Target 5' aaTATGGGGCAGACTAGGGAAAc 3'
 270 - 292 152.00 -13.50
2 
miRNA  3' cgguucccUUACCGUCCCUUUa 5'
                  :||  |||||||| 
Target 5' gccttgatGATCTCAGGGAAAa 3'
 1089 - 1110 150.00 -13.90
3 
miRNA  3' cggUUCCCUU----A-CCGUCCCUUua 5'
             |:|||||    |  |:||||||  
Target 5' aggAGGGGAAGTCTTCAGTAGGGAAca 3'
 311 - 337 137.00 -16.70
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30113162 8 COSMIC
COSN21080838 23 COSMIC
COSN30484550 26 COSMIC
COSN20078906 60 COSMIC
COSN31511114 79 COSMIC
COSN30127286 126 COSMIC
COSN18837868 343 COSMIC
COSN32055747 741 COSMIC
COSN14583834 768 COSMIC
COSN32056169 823 COSMIC
COSN31547327 1023 COSMIC
COSN31487785 1133 COSMIC
COSN28813298 1267 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1192135567 3 dbSNP
rs1446653116 4 dbSNP
rs180894805 9 dbSNP
rs776312472 11 dbSNP
rs761400564 13 dbSNP
rs1423367723 20 dbSNP
rs764750613 21 dbSNP
rs1172728084 22 dbSNP
rs1360963554 23 dbSNP
rs185946193 26 dbSNP
rs758264699 28 dbSNP
rs766298248 29 dbSNP
rs1436655905 32 dbSNP
rs751553532 35 dbSNP
rs754492085 35 dbSNP
rs1178015626 36 dbSNP
rs1023084148 41 dbSNP
rs1276228788 47 dbSNP
rs754781005 51 dbSNP
rs780890795 52 dbSNP
rs1310365611 53 dbSNP
rs1244458324 56 dbSNP
rs1298088820 59 dbSNP
rs975500871 61 dbSNP
rs1242288069 66 dbSNP
rs568172020 66 dbSNP
rs1319145096 80 dbSNP
rs1284312662 101 dbSNP
rs970200539 104 dbSNP
rs1360716674 114 dbSNP
rs554754075 118 dbSNP
rs984743959 121 dbSNP
rs1242869030 123 dbSNP
rs1378507046 133 dbSNP
rs1289711229 137 dbSNP
rs913154615 139 dbSNP
rs945916986 158 dbSNP
rs981290660 164 dbSNP
rs772460708 166 dbSNP
rs1425227181 168 dbSNP
rs750136093 169 dbSNP
rs928476300 170 dbSNP
rs1161155496 175 dbSNP
rs1422776417 180 dbSNP
rs1187963199 183 dbSNP
rs1261773081 183 dbSNP
rs1285250344 185 dbSNP
rs1484679436 186 dbSNP
rs555601609 189 dbSNP
rs76126995 211 dbSNP
rs1487246249 213 dbSNP
rs780693107 214 dbSNP
rs572776258 216 dbSNP
rs937150622 227 dbSNP
rs1261738876 229 dbSNP
rs971737511 230 dbSNP
rs1321267478 232 dbSNP
rs1422937031 233 dbSNP
rs1184953956 234 dbSNP
rs1055588041 236 dbSNP
rs918954949 237 dbSNP
rs533587297 238 dbSNP
rs887380260 239 dbSNP
rs1051551038 251 dbSNP
rs747635553 254 dbSNP
rs1422411561 255 dbSNP
rs888913243 257 dbSNP
rs535396131 262 dbSNP
rs943225682 265 dbSNP
rs1402739323 269 dbSNP
rs769398310 270 dbSNP
rs900042571 272 dbSNP
rs1421983734 275 dbSNP
rs1251972456 292 dbSNP
rs1043337965 298 dbSNP
rs556731066 300 dbSNP
rs1032428514 307 dbSNP
rs1277856718 309 dbSNP
rs1224319663 315 dbSNP
rs558540706 319 dbSNP
rs1401581571 320 dbSNP
rs1298900987 322 dbSNP
rs1386150942 323 dbSNP
rs999204513 330 dbSNP
rs1031622707 335 dbSNP
rs577440833 339 dbSNP
rs1460073653 350 dbSNP
rs1394553532 357 dbSNP
rs1336378265 358 dbSNP
rs1383739163 361 dbSNP
rs1481205963 363 dbSNP
rs1246483304 364 dbSNP
rs1197121910 370 dbSNP
rs1308175070 374 dbSNP
rs117573973 377 dbSNP
rs1020942954 378 dbSNP
rs1241080236 385 dbSNP
rs1023011992 388 dbSNP
rs1257495734 390 dbSNP
rs1260874331 394 dbSNP
rs1325853252 402 dbSNP
rs981386043 408 dbSNP
rs1198418950 412 dbSNP
rs562701483 415 dbSNP
rs762715351 416 dbSNP
rs770774590 419 dbSNP
rs1470755890 421 dbSNP
rs1403394709 425 dbSNP
rs1171211218 435 dbSNP
rs189666902 444 dbSNP
rs919701398 445 dbSNP
rs147250048 450 dbSNP
rs1438364306 452 dbSNP
rs1160434646 456 dbSNP
rs973429053 457 dbSNP
rs1377190848 458 dbSNP
rs1464629162 465 dbSNP
rs918923914 469 dbSNP
rs954364269 473 dbSNP
rs987185503 480 dbSNP
rs774154879 481 dbSNP
rs1262258512 503 dbSNP
rs943701324 512 dbSNP
rs1352812685 518 dbSNP
rs1446248903 519 dbSNP
rs796068019 524 dbSNP
rs1338166395 525 dbSNP
rs1333142878 526 dbSNP
rs1382431472 527 dbSNP
rs1386200704 529 dbSNP
rs1374374996 531 dbSNP
rs943175258 533 dbSNP
rs1418409081 540 dbSNP
rs1393107244 544 dbSNP
rs181213847 558 dbSNP
rs767371362 563 dbSNP
rs1366797696 569 dbSNP
rs934590012 583 dbSNP
rs1052966801 584 dbSNP
rs1187181034 585 dbSNP
rs185994947 593 dbSNP
rs1032893629 596 dbSNP
rs552252949 598 dbSNP
rs1044433663 599 dbSNP
rs564510346 605 dbSNP
rs1248037678 612 dbSNP
rs1353727474 626 dbSNP
rs1283070385 630 dbSNP
rs777757590 632 dbSNP
rs905928055 639 dbSNP
rs1327757853 642 dbSNP
rs1006077869 646 dbSNP
rs1267307147 664 dbSNP
rs1017094645 668 dbSNP
rs1035616260 669 dbSNP
rs1178698009 675 dbSNP
rs2303506 681 dbSNP
rs994391538 682 dbSNP
rs1029928998 691 dbSNP
rs10445322 698 dbSNP
rs1465360751 707 dbSNP
rs760875258 708 dbSNP
rs1162670589 712 dbSNP
rs919779720 720 dbSNP
rs954333212 720 dbSNP
rs1352595604 729 dbSNP
rs987154388 734 dbSNP
rs1463349093 736 dbSNP
rs557361200 738 dbSNP
rs1477395361 739 dbSNP
rs952565497 740 dbSNP
rs764385191 743 dbSNP
rs982531876 750 dbSNP
rs908294713 752 dbSNP
rs1195826069 755 dbSNP
rs779453808 758 dbSNP
rs1275958309 759 dbSNP
rs964482126 762 dbSNP
rs1217632588 766 dbSNP
rs1384944796 770 dbSNP
rs943707710 779 dbSNP
rs754167190 784 dbSNP
rs1439225960 786 dbSNP
rs190453563 791 dbSNP
rs1040652667 792 dbSNP
rs539781889 799 dbSNP
rs921530561 800 dbSNP
rs925767090 814 dbSNP
rs1168882886 820 dbSNP
rs1465285596 821 dbSNP
rs1429748828 829 dbSNP
rs934495380 831 dbSNP
rs9894355 840 dbSNP
rs1477016261 849 dbSNP
rs1246003718 853 dbSNP
rs183437034 860 dbSNP
rs1054021839 865 dbSNP
rs1205667694 871 dbSNP
rs536478557 872 dbSNP
rs1197644651 879 dbSNP
rs1323719612 887 dbSNP
rs917189605 905 dbSNP
rs1265171055 907 dbSNP
rs1487826204 913 dbSNP
rs1221247583 916 dbSNP
rs1365904407 918 dbSNP
rs893993982 920 dbSNP
rs779270040 924 dbSNP
rs1379283729 932 dbSNP
rs11556499 933 dbSNP
rs1044347589 934 dbSNP
rs1269741547 937 dbSNP
rs905867270 940 dbSNP
rs1477524277 953 dbSNP
rs1191534843 954 dbSNP
rs1421951315 963 dbSNP
rs548252826 967 dbSNP
rs1177990033 969 dbSNP
rs13477 971 dbSNP
rs750764787 992 dbSNP
rs140981103 1003 dbSNP
rs1424203300 1008 dbSNP
rs906582106 1019 dbSNP
rs1441408189 1023 dbSNP
rs1003558596 1024 dbSNP
rs1177425699 1024 dbSNP
rs1461509108 1025 dbSNP
rs1038900055 1028 dbSNP
rs1207551330 1033 dbSNP
rs1170892224 1036 dbSNP
rs780457644 1041 dbSNP
rs1033657263 1054 dbSNP
rs1278344424 1066 dbSNP
rs1224839764 1075 dbSNP
rs897313610 1076 dbSNP
rs994366090 1077 dbSNP
rs1422716982 1092 dbSNP
rs1383583571 1094 dbSNP
rs931385704 1102 dbSNP
rs1366066016 1118 dbSNP
rs1446078312 1126 dbSNP
rs1358380772 1131 dbSNP
rs1398886325 1134 dbSNP
rs747628611 1137 dbSNP
rs769343182 1143 dbSNP
rs1378352901 1149 dbSNP
rs1157953719 1155 dbSNP
rs1363656157 1163 dbSNP
rs142459599 1167 dbSNP
rs1179814608 1169 dbSNP
rs952694888 1178 dbSNP
rs1237269154 1182 dbSNP
rs1217748383 1185 dbSNP
rs1007160308 1187 dbSNP
rs1312543049 1187 dbSNP
rs1240014340 1190 dbSNP
rs1322468651 1197 dbSNP
rs1314874082 1202 dbSNP
rs186256815 1212 dbSNP
rs908305613 1212 dbSNP
rs1270575464 1234 dbSNP
rs1225429312 1236 dbSNP
rs1293167074 1239 dbSNP
rs1358358627 1243 dbSNP
rs576438545 1246 dbSNP
rs1214544058 1251 dbSNP
rs1243857455 1259 dbSNP
rs115562564 1261 dbSNP
rs1033207091 1263 dbSNP
rs1181468382 1264 dbSNP
rs192160159 1266 dbSNP
rs1422912445 1269 dbSNP
rs1419725532 1270 dbSNP
rs770578511 1275 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Disease 58488.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM714644. RNA binding protein: AGO2. Condition:completeT1 ...

- Kishore S; Jaskiewicz L; Burger L; Hausser et al., 2011, Nature methods.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' cgguucccuUACCGUCCCUUUa 5'
                   ||  |||||||| 
Target 5' ---------AUCUCAGGGAAAa 3'
 		1 - 13
Article - Kishore S; Jaskiewicz L; Burger L; Hausser et al.
- Nature methods, 2011
Cross-linking and immunoprecipitation (CLIP) is increasingly used to map transcriptome-wide binding sites of RNA-binding proteins. We developed a method for CLIP data analysis, and applied it to compare CLIP with photoactivatable ribonucleoside-enhanced CLIP (PAR-CLIP) and to uncover how differences in cross-linking and ribonuclease digestion affect the identified sites. We found only small differences in accuracies of these methods in identifying binding sites of HuR, which binds low-complexity sequences, and Argonaute 2, which has a complex binding specificity. We found that cross-link-induced mutations led to single-nucleotide resolution for both PAR-CLIP and CLIP. Our results confirm the expectation from original CLIP publications that RNA-binding proteins do not protect their binding sites sufficiently under the denaturing conditions used during the CLIP procedure, and we show that extensive digestion with sequence-specific RNases strongly biases the recovered binding sites. This bias can be substantially reduced by milder nuclease digestion conditions.
LinkOut: [PMID: 21572407]
CLIP-seq Support 1 for dataset GSM4903825
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / PID14_NS
Location of target site NM_001102402 | 3UTR | AGCCUUGAUGAUCUCAGGGAAAAAUUUUAAUCACUGUGUAUAAUGAUACUGAACCUUGAUUAAUAACAGAAAUUCAGGAUGUAAAGCCACAGAAUGGGAUU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161237
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM714644
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / completeT1, repA
Location of target site ENST00000576183.1 | 3UTR | AUCUCAGGGAAAAAUUUUAAUCACUGUGUAUAAUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 21572407 / GSE28865
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
223 hsa-miR-4446-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT078060 PCTP phosphatidylcholine transfer protein 2 2
MIRT099072 FOXC1 forkhead box C1 2 2
MIRT130186 TXNIP thioredoxin interacting protein 2 2
MIRT148786 NARS asparaginyl-tRNA synthetase 2 2
MIRT261965 SEPHS1 selenophosphate synthetase 1 2 2
MIRT345867 SRSF2 serine and arginine rich splicing factor 2 2 2
MIRT409087 HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 2 2
MIRT451883 SOD2 superoxide dismutase 2 2 4
MIRT469236 RHOB ras homolog family member B 2 2
MIRT469435 REL REL proto-oncogene, NF-kB subunit 2 2
MIRT483055 FOXB1 forkhead box B1 2 8
MIRT484640 TBC1D5 TBC1 domain family member 5 2 6
MIRT493106 MKNK2 MAP kinase interacting serine/threonine kinase 2 2 6
MIRT497307 TMEFF2 transmembrane protein with EGF like and two follistatin like domains 2 2 2
MIRT497798 GABRB1 gamma-aminobutyric acid type A receptor beta1 subunit 2 2
MIRT501273 SCARB2 scavenger receptor class B member 2 2 4
MIRT506756 KMT2D lysine methyltransferase 2D 2 2
MIRT511986 EEF2 eukaryotic translation elongation factor 2 2 4
MIRT513126 ZNF431 zinc finger protein 431 2 2
MIRT519733 ZNF394 zinc finger protein 394 2 4
MIRT520351 UBE2K ubiquitin conjugating enzyme E2 K 2 4
MIRT520542 TPPP tubulin polymerization promoting protein 2 8
MIRT530782 HDHD2 haloacid dehalogenase like hydrolase domain containing 2 2 2
MIRT531112 ZYG11B zyg-11 family member B, cell cycle regulator 2 2
MIRT532144 GALNT8 polypeptide N-acetylgalactosaminyltransferase 8 2 2
MIRT533208 WAPAL WAPL cohesin release factor 2 2
MIRT533419 TWF1 twinfilin actin binding protein 1 2 2
MIRT534063 SRSF10 serine and arginine rich splicing factor 10 2 2
MIRT534288 SLAIN2 SLAIN motif family member 2 2 2
MIRT537796 EFNB2 ephrin B2 2 2
MIRT538017 DNAJC10 DnaJ heat shock protein family (Hsp40) member C10 2 2
MIRT538058 DMD dystrophin 2 2
MIRT538132 DDI2 DNA damage inducible 1 homolog 2 2 2
MIRT538680 CCDC80 coiled-coil domain containing 80 2 2
MIRT538788 C3orf52 chromosome 3 open reading frame 52 2 2
MIRT542762 PPAP2B phospholipid phosphatase 3 2 2
MIRT546861 RAB10 RAB10, member RAS oncogene family 2 4
MIRT547418 MED4 mediator complex subunit 4 2 4
MIRT551633 TRUB1 TruB pseudouridine synthase family member 1 2 4
MIRT552329 ZNF704 zinc finger protein 704 2 2
MIRT556124 MFSD9 major facilitator superfamily domain containing 9 2 4
MIRT559290 ATXN1 ataxin 1 2 2
MIRT562125 IGFBP5 insulin like growth factor binding protein 5 2 2
MIRT563777 HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 2 2
MIRT564430 EIF2S3 eukaryotic translation initiation factor 2 subunit gamma 2 2
MIRT566102 RBPJ recombination signal binding protein for immunoglobulin kappa J region 2 2
MIRT567126 IRF2BP2 interferon regulatory factor 2 binding protein 2 2 2
MIRT571213 RRS1 ribosome biogenesis regulator homolog 2 2
MIRT571939 LCLAT1 lysocardiolipin acyltransferase 1 2 2
MIRT571967 KIF21A kinesin family member 21A 2 2
MIRT606792 IL1RAPL1 interleukin 1 receptor accessory protein like 1 2 8
MIRT607351 TNS1 tensin 1 2 4
MIRT609416 GJB7 gap junction protein beta 7 2 4
MIRT609522 AZI2 5-azacytidine induced 2 2 4
MIRT611218 FAM174B family with sequence similarity 174 member B 2 2
MIRT611385 TRIP10 thyroid hormone receptor interactor 10 2 2
MIRT612053 KLB klotho beta 2 4
MIRT612102 CHRM3 cholinergic receptor muscarinic 3 2 2
MIRT612146 SIX1 SIX homeobox 1 2 4
MIRT612488 SIX3 SIX homeobox 3 2 4
MIRT613685 QPRT quinolinate phosphoribosyltransferase 2 2
MIRT613763 TTC38 tetratricopeptide repeat domain 38 2 2
MIRT613876 FGD1 FYVE, RhoGEF and PH domain containing 1 2 2
MIRT613965 PPP1R3D protein phosphatase 1 regulatory subunit 3D 2 4
MIRT614894 PAPOLG poly(A) polymerase gamma 2 2
MIRT614912 NFIA nuclear factor I A 2 2
MIRT615013 ERGIC2 ERGIC and golgi 2 2 2
MIRT615106 BCL7A BCL tumor suppressor 7A 2 2
MIRT615242 FAM227A family with sequence similarity 227 member A 2 4
MIRT615695 NEGR1 neuronal growth regulator 1 2 2
MIRT615956 ERBB3 erb-b2 receptor tyrosine kinase 3 2 4
MIRT615979 FSTL4 follistatin like 4 2 2
MIRT616053 PTPRE protein tyrosine phosphatase, receptor type E 2 4
MIRT616073 TBX2 T-box 2 2 4
MIRT616234 NPAS3 neuronal PAS domain protein 3 2 2
MIRT616306 CELF2 CUGBP Elav-like family member 2 2 2
MIRT616474 MACC1 MACC1, MET transcriptional regulator 2 2
MIRT616662 ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 2 2
MIRT616887 ATP5E ATP synthase, H+ transporting, mitochondrial F1 complex, epsilon subunit 2 2
MIRT616902 LINC00598 long intergenic non-protein coding RNA 598 2 2
MIRT617025 SYT6 synaptotagmin 6 2 2
MIRT617162 SLC16A5 solute carrier family 16 member 5 2 2
MIRT617318 DPF3 double PHD fingers 3 2 2
MIRT617792 CHRM2 cholinergic receptor muscarinic 2 2 2
MIRT618418 DNAJC30 DnaJ heat shock protein family (Hsp40) member C30 2 2
MIRT618663 RPP40 ribonuclease P/MRP subunit p40 2 2
MIRT620212 VN1R1 vomeronasal 1 receptor 1 2 2
MIRT620413 TFDP3 transcription factor Dp family member 3 2 2
MIRT620667 BBS5 Bardet-Biedl syndrome 5 2 2
MIRT620709 ASB16 ankyrin repeat and SOCS box containing 16 2 2
MIRT620956 SFT2D2 SFT2 domain containing 2 2 2
MIRT621225 LMAN1 lectin, mannose binding 1 2 2
MIRT621333 SLC11A1 solute carrier family 11 member 1 2 2
MIRT621696 TSKU tsukushi, small leucine rich proteoglycan 2 2
MIRT623484 KCTD11 potassium channel tetramerization domain containing 11 2 2
MIRT623777 GOSR1 golgi SNAP receptor complex member 1 2 2
MIRT624215 DCAF5 DDB1 and CUL4 associated factor 5 2 2
MIRT624675 ARAP2 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 2 2
MIRT627369 PRICKLE4 prickle planar cell polarity protein 4 2 2
MIRT628252 EFCAB14 EF-hand calcium binding domain 14 2 2
MIRT630790 TGIF2 TGFB induced factor homeobox 2 2 2
MIRT635631 PRR15L proline rich 15 like 2 2
MIRT636425 MARCH1 membrane associated ring-CH-type finger 1 2 2
MIRT637295 ACTN2 actinin alpha 2 2 2
MIRT637345 PIGP phosphatidylinositol glycan anchor biosynthesis class P 2 2
MIRT637842 SLC2A9 solute carrier family 2 member 9 2 2
MIRT638327 RCAN1 regulator of calcineurin 1 2 2
MIRT638375 RABL3 RAB, member of RAS oncogene family like 3 2 2
MIRT638751 EPHA4 EPH receptor A4 2 2
MIRT638965 ARHGAP6 Rho GTPase activating protein 6 2 2
MIRT639094 GLIPR1L2 GLI pathogenesis related 1 like 2 2 2
MIRT639172 CEP70 centrosomal protein 70 2 2
MIRT639254 SLC38A1 solute carrier family 38 member 1 2 4
MIRT639368 ZCCHC24 zinc finger CCHC-type containing 24 2 4
MIRT639504 CACNA1G calcium voltage-gated channel subunit alpha1 G 2 2
MIRT639644 WHAMM WAS protein homolog associated with actin, golgi membranes and microtubules 2 2
MIRT640486 EXOC5 exocyst complex component 5 2 2
MIRT641424 SCUBE3 signal peptide, CUB domain and EGF like domain containing 3 2 2
MIRT641550 LIPG lipase G, endothelial type 2 2
MIRT642180 TOR1AIP1 torsin 1A interacting protein 1 2 2
MIRT642656 RGS6 regulator of G protein signaling 6 2 2
MIRT642873 SAMD1 sterile alpha motif domain containing 1 2 2
MIRT643355 TRIM10 tripartite motif containing 10 2 2
MIRT643531 DNTTIP2 deoxynucleotidyltransferase terminal interacting protein 2 2 2
MIRT643998 PPP1R3G protein phosphatase 1 regulatory subunit 3G 2 2
MIRT644105 PHLPP1 PH domain and leucine rich repeat protein phosphatase 1 2 2
MIRT644421 VDR vitamin D receptor 2 2
MIRT644481 SLFN12 schlafen family member 12 2 2
MIRT644573 SPOP speckle type BTB/POZ protein 2 2
MIRT645354 SPNS1 sphingolipid transporter 1 (putative) 2 2
MIRT645383 FBLIM1 filamin binding LIM protein 1 2 2
MIRT645758 SURF6 surfeit 6 2 2
MIRT646060 VANGL2 VANGL planar cell polarity protein 2 2 2
MIRT646194 DUSP10 dual specificity phosphatase 10 2 2
MIRT647915 RGS5 regulator of G protein signaling 5 2 2
MIRT649216 AMMECR1L AMMECR1 like 2 2
MIRT649265 C17orf64 chromosome 17 open reading frame 64 2 2
MIRT649522 GTF3C3 general transcription factor IIIC subunit 3 2 2
MIRT649605 ITPKC inositol-trisphosphate 3-kinase C 2 2
MIRT650392 ORMDL2 ORMDL sphingolipid biosynthesis regulator 2 2 2
MIRT650835 SEMA4G semaphorin 4G 2 2
MIRT651273 ZDHHC5 zinc finger DHHC-type containing 5 2 2
MIRT651674 VPS37A VPS37A, ESCRT-I subunit 2 2
MIRT651763 VASP vasodilator stimulated phosphoprotein 2 2
MIRT652250 TPD52L3 tumor protein D52 like 3 2 2
MIRT652277 TOM1L2 target of myb1 like 2 membrane trafficking protein 2 2
MIRT652316 TNFSF15 TNF superfamily member 15 2 2
MIRT652342 TMOD3 tropomodulin 3 2 2
MIRT652373 TMEM57 transmembrane protein 57 2 2
MIRT652438 TMEM236 transmembrane protein 236 2 2
MIRT652723 TGFB2 transforming growth factor beta 2 2 2
MIRT652752 TET3 tet methylcytosine dioxygenase 3 2 2
MIRT653310 SMOC1 SPARC related modular calcium binding 1 2 2
MIRT653327 SMIM18 small integral membrane protein 18 2 2
MIRT653406 SLC7A2 solute carrier family 7 member 2 2 2
MIRT653512 SLC41A1 solute carrier family 41 member 1 2 2
MIRT653912 SERPINC1 serpin family C member 1 2 2
MIRT654111 RPS6KA5 ribosomal protein S6 kinase A5 2 2
MIRT654153 RORB RAR related orphan receptor B 2 2
MIRT654548 RAB14 RAB14, member RAS oncogene family 2 2
MIRT654920 POLR3D RNA polymerase III subunit D 2 2
MIRT655169 PHF19 PHD finger protein 19 2 2
MIRT655412 PAN2 PAN2 poly(A) specific ribonuclease subunit 2 2
MIRT655784 NOVA2 NOVA alternative splicing regulator 2 2 2
MIRT655836 NGDN neuroguidin 2 2
MIRT656079 MTA3 metastasis associated 1 family member 3 2 2
MIRT656404 MCTP1 multiple C2 and transmembrane domain containing 1 2 2
MIRT656720 LMLN leishmanolysin like peptidase 2 2
MIRT656774 LARP1 La ribonucleoprotein domain family member 1 2 2
MIRT656922 KIAA1462 junctional cadherin 5 associated 2 2
MIRT657004 KCNMB4 potassium calcium-activated channel subfamily M regulatory beta subunit 4 2 2
MIRT657477 HCAR2 hydroxycarboxylic acid receptor 2 2 2
MIRT657539 GSTO2 glutathione S-transferase omega 2 2 2
MIRT657911 GCC1 GRIP and coiled-coil domain containing 1 2 2
MIRT658478 EXOC8 exocyst complex component 8 2 2
MIRT658612 ENPP5 ectonucleotide pyrophosphatase/phosphodiesterase 5 (putative) 2 2
MIRT658823 SRCAP Snf2 related CREBBP activator protein 2 2
MIRT658965 DNAJB5 DnaJ heat shock protein family (Hsp40) member B5 2 4
MIRT659706 CCDC93 coiled-coil domain containing 93 2 2
MIRT660034 C15orf61 chromosome 15 open reading frame 61 2 2
MIRT660108 BTBD3 BTB domain containing 3 2 2
MIRT660697 AMOTL2 angiomotin like 2 2 2
MIRT660763 ALDH6A1 aldehyde dehydrogenase 6 family member A1 2 2
MIRT660884 ADCYAP1R1 ADCYAP receptor type I 2 2
MIRT660956 ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 2 2
MIRT661217 SCIMP SLP adaptor and CSK interacting membrane protein 2 2
MIRT661596 C2orf15 chromosome 2 open reading frame 15 2 2
MIRT661624 UGT2B28 UDP glucuronosyltransferase family 2 member B28 2 2
MIRT662430 EID2 EP300 interacting inhibitor of differentiation 2 2 2
MIRT664816 NOX5 NADPH oxidase 5 2 2
MIRT665548 UCHL5 ubiquitin C-terminal hydrolase L5 2 2
MIRT665815 TMEM161B transmembrane protein 161B 2 2
MIRT666668 RBM23 RNA binding motif protein 23 2 2
MIRT667995 HCFC2 host cell factor C2 2 2
MIRT668064 GPR180 G protein-coupled receptor 180 2 2
MIRT669056 CELSR3 cadherin EGF LAG seven-pass G-type receptor 3 2 2
MIRT669637 ACSBG1 acyl-CoA synthetase bubblegum family member 1 2 2
MIRT699368 SLC30A6 solute carrier family 30 member 6 2 2
MIRT699882 RUNX1 runt related transcription factor 1 2 2
MIRT703834 ETV3 ETS variant 3 2 2
MIRT708528 ZNF177 zinc finger protein 177 2 2
MIRT709696 DMWD DM1 locus, WD repeat containing 2 2
MIRT710381 PARD6G par-6 family cell polarity regulator gamma 2 2
MIRT710639 GLUL glutamate-ammonia ligase 2 2
MIRT711584 SETD1A SET domain containing 1A 2 2
MIRT713208 FAM13A family with sequence similarity 13 member A 2 2
MIRT714129 IL20RB interleukin 20 receptor subunit beta 2 2
MIRT714204 MRE11A MRE11 homolog, double strand break repair nuclease 2 2
MIRT714733 CCNO cyclin O 2 2
MIRT714761 ZNF462 zinc finger protein 462 2 2
MIRT715624 ZBTB8B zinc finger and BTB domain containing 8B 2 2
MIRT715755 SKA2 spindle and kinetochore associated complex subunit 2 2 2
MIRT716075 RNF150 ring finger protein 150 2 2
MIRT716179 MTRNR2L1 MT-RNR2-like 1 2 2
MIRT717450 RWDD2A RWD domain containing 2A 2 2
MIRT717866 CACNA2D1 calcium voltage-gated channel auxiliary subunit alpha2delta 1 2 2
MIRT720964 ZBTB43 zinc finger and BTB domain containing 43 2 2
MIRT721564 SLC5A12 solute carrier family 5 member 12 2 2
MIRT722348 BAG2 BCL2 associated athanogene 2 2 2
MIRT723235 BTLA B and T lymphocyte associated 2 2
MIRT724018 LMBRD2 LMBR1 domain containing 2 2 2
MIRT724507 KLHL5 kelch like family member 5 2 2
MIRT725478 GPR26 G protein-coupled receptor 26 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-4446 Aed Therapy sensitive High Epilepsy tissue
hsa-mir-4446 Ceritinib 57379345 NSC776422 approved sensitive High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-mir-4446 Androstenedione+Letrozole sensitive cell line (MCF-7)
hsa-mir-4446 Tamoxifen 2733525 NSC180973 approved resistant cell line (MCF7)
hsa-mir-4446 Cisplatin 5460033 NSC119875 approved resistant cell line (BxPC3)
hsa-mir-4446 Ceritinib 57379345 NSC776422 approved sensitive cell line (H3122)
hsa-miR-4446-5p Cisplatin 5460033 NSC119875 approved resistant cell line (A549)
hsa-miR-4446-5p Paclitaxel 36314 NSC125973 approved resistant cell line (A2780)
hsa-miR-4446-5p Neoadjuvant chemotherapy resistant tissue (breast cancer)
hsa-miR-4446-5p Ceritinib 57379345 NSC776422 approved sensitive cell line (H3122)

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