miRTarBase - #MIRT078065


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pre-miRNA Information
pre-miRNA hsa-mir-5694   
Genomic Coordinates chr14: 67441855 - 67441930
Description Homo sapiens miR-5694 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-5694
Sequence 9| CAGAUCAUGGGACUGUCUCAG |29
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs115811718 9 dbSNP
rs186792979 10 dbSNP
rs905691898 13 dbSNP
rs1400928606 20 dbSNP
Putative Targets

Gene Information
Gene Symbol PCTP   
Synonyms PC-TP, STARD2
Description phosphatidylcholine transfer protein
Transcript NM_001102402   
Other Transcripts NM_021213   
Expression
Putative miRNA Targets on PCTP
3'UTR of PCTP
(miRNA target sites are highlighted)		 
>PCTP|NM_001102402|3'UTR
   1 GAAAGAGAACTGGGAACATTGCATCCATGGGTTGATGTCTCTGGAAGTGCAACCACCCAATGTCTCTGGAAGTGCCACCT
  81 GGAAGTGCCACCTGGAAGTGTCTCTGGAAGAGCACCCACCACTGTTCAGCCTTCCCCTGCTGTTTCTGTCTTCAGAGGCC
 161 TACACACTACCACATCCTTTCTAAGCATGTTTGCCTGACATCCAGCTCACTCGTCTGCTTCCTTTCTCGCTCCCCCCATC
 241 CTGGGCTGGGCTGCCTTCTTCTACAGTTCAATATGGGGCAGACTAGGGAAACCTTTGCTTGCTTACTATTAGGAGGGGAA
 321 GTCTTCAGTAGGGAACACGATCATTCCATTGTGCAATTTTACGGGGATGGGTGGGCGGAGGGACACAACAAAATTTAAGA
 401 ATGACTATTTGGGCGGGCTGGCTCTTTTGCAGCTTGTGATTTCTTCCAGCTTGGGAGGGGCTGCTGGAAGTGGCATTTCG
 481 TTCAGAGCTGACTTTCAGTGCACCCAAACTGGATGACGTGCCAATGTCCATTTGCCTTATGCTTTGTGGAGCTGATTAGG
 561 CTGGGATTTGAGGTGATAATCCAGTAAGTCTTTCCTCGTTCCTACTTGTGGAGGATCAGTAGCTGTTATGATGCCAGACC
 641 ATTTGGAGAAGTATCAGAGGCCTGACCGGACACATAATATGACAACCACATTTTTCCTCATCATCCATGAGGAAATGGAT
 721 GATTTCTCTTTTCCATATGTCACTGGGGGAAAGGCTGCCTGTACCTCTCAAGCTTTGCATTTTACTGGAAACTGAGGCGT
 801 CAAGATGGCTGTGGCAGCTAGCAAAAGCAAAGATGCTTTGTGCATAGCCTTGTGAAAAAGTATCTTTCTATGCAATAAGA
 881 TGAATTTTCCTCCCAGAATATTTAGAAATGTAGAAGGGATAACAGTTCACAGCCAGGTAAAATTTAACTGGTGGCTTAAT
 961 GACTCTGCACCTTTTTCTCAGGAATTCTGCCTAAGTTGTCTGCCTTTTCTACCACCAAAAAGACTTTTAGTTTTCTATGC
1041 TTTCTCCTGAATTTTGGTAGGGTAAGGTATTTCTATGTCAAAGGCACAGCCTTGATGATCTCAGGGAAAAATTTTAATCA
1121 CTGTGTATAATGATACTGAACCTTGATTAATAACAGAAATTCAGGATGTAAAGCCACAGAATGGGATTTATTAATGTGGG
1201 ATACCTCAGACTGTTTGTTTTCTTTCTGGGAAGAAAAGTGTGTTCTATAATGAATAAATATAGAGTGGTTTTTACTTGTC
1281 CTGTGTAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' gaCUCUGUCAGGG-UACUAGAc 5'
            |: |||| |:: ||||||| 
Target 5' aaGGCACAGCCTTGATGATCTc 3'
 1081 - 1102 159.00 -13.50
2 
miRNA  3' gaCUCUGUCAGGGUACUAGAc 5'
            |||: | |   |||||:| 
Target 5' atGAGGAAAT-GGATGATTTc 3'
 707 - 726 130.00 -8.42
3 
miRNA  3' gacucUGUCAGGGUACUAGAc 5'
               :||| |:::||||:| 
Target 5' cttttGCAG-CTTGTGATTTc 3'
 424 - 443 123.00 -10.30
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30113162 8 COSMIC
COSN21080838 23 COSMIC
COSN30484550 26 COSMIC
COSN20078906 60 COSMIC
COSN31511114 79 COSMIC
COSN30127286 126 COSMIC
COSN18837868 343 COSMIC
COSN32055747 741 COSMIC
COSN14583834 768 COSMIC
COSN32056169 823 COSMIC
COSN31547327 1023 COSMIC
COSN31487785 1133 COSMIC
COSN28813298 1267 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1192135567 3 dbSNP
rs1446653116 4 dbSNP
rs180894805 9 dbSNP
rs776312472 11 dbSNP
rs761400564 13 dbSNP
rs1423367723 20 dbSNP
rs764750613 21 dbSNP
rs1172728084 22 dbSNP
rs1360963554 23 dbSNP
rs185946193 26 dbSNP
rs758264699 28 dbSNP
rs766298248 29 dbSNP
rs1436655905 32 dbSNP
rs751553532 35 dbSNP
rs754492085 35 dbSNP
rs1178015626 36 dbSNP
rs1023084148 41 dbSNP
rs1276228788 47 dbSNP
rs754781005 51 dbSNP
rs780890795 52 dbSNP
rs1310365611 53 dbSNP
rs1244458324 56 dbSNP
rs1298088820 59 dbSNP
rs975500871 61 dbSNP
rs1242288069 66 dbSNP
rs568172020 66 dbSNP
rs1319145096 80 dbSNP
rs1284312662 101 dbSNP
rs970200539 104 dbSNP
rs1360716674 114 dbSNP
rs554754075 118 dbSNP
rs984743959 121 dbSNP
rs1242869030 123 dbSNP
rs1378507046 133 dbSNP
rs1289711229 137 dbSNP
rs913154615 139 dbSNP
rs945916986 158 dbSNP
rs981290660 164 dbSNP
rs772460708 166 dbSNP
rs1425227181 168 dbSNP
rs750136093 169 dbSNP
rs928476300 170 dbSNP
rs1161155496 175 dbSNP
rs1422776417 180 dbSNP
rs1187963199 183 dbSNP
rs1261773081 183 dbSNP
rs1285250344 185 dbSNP
rs1484679436 186 dbSNP
rs555601609 189 dbSNP
rs76126995 211 dbSNP
rs1487246249 213 dbSNP
rs780693107 214 dbSNP
rs572776258 216 dbSNP
rs937150622 227 dbSNP
rs1261738876 229 dbSNP
rs971737511 230 dbSNP
rs1321267478 232 dbSNP
rs1422937031 233 dbSNP
rs1184953956 234 dbSNP
rs1055588041 236 dbSNP
rs918954949 237 dbSNP
rs533587297 238 dbSNP
rs887380260 239 dbSNP
rs1051551038 251 dbSNP
rs747635553 254 dbSNP
rs1422411561 255 dbSNP
rs888913243 257 dbSNP
rs535396131 262 dbSNP
rs943225682 265 dbSNP
rs1402739323 269 dbSNP
rs769398310 270 dbSNP
rs900042571 272 dbSNP
rs1421983734 275 dbSNP
rs1251972456 292 dbSNP
rs1043337965 298 dbSNP
rs556731066 300 dbSNP
rs1032428514 307 dbSNP
rs1277856718 309 dbSNP
rs1224319663 315 dbSNP
rs558540706 319 dbSNP
rs1401581571 320 dbSNP
rs1298900987 322 dbSNP
rs1386150942 323 dbSNP
rs999204513 330 dbSNP
rs1031622707 335 dbSNP
rs577440833 339 dbSNP
rs1460073653 350 dbSNP
rs1394553532 357 dbSNP
rs1336378265 358 dbSNP
rs1383739163 361 dbSNP
rs1481205963 363 dbSNP
rs1246483304 364 dbSNP
rs1197121910 370 dbSNP
rs1308175070 374 dbSNP
rs117573973 377 dbSNP
rs1020942954 378 dbSNP
rs1241080236 385 dbSNP
rs1023011992 388 dbSNP
rs1257495734 390 dbSNP
rs1260874331 394 dbSNP
rs1325853252 402 dbSNP
rs981386043 408 dbSNP
rs1198418950 412 dbSNP
rs562701483 415 dbSNP
rs762715351 416 dbSNP
rs770774590 419 dbSNP
rs1470755890 421 dbSNP
rs1403394709 425 dbSNP
rs1171211218 435 dbSNP
rs189666902 444 dbSNP
rs919701398 445 dbSNP
rs147250048 450 dbSNP
rs1438364306 452 dbSNP
rs1160434646 456 dbSNP
rs973429053 457 dbSNP
rs1377190848 458 dbSNP
rs1464629162 465 dbSNP
rs918923914 469 dbSNP
rs954364269 473 dbSNP
rs987185503 480 dbSNP
rs774154879 481 dbSNP
rs1262258512 503 dbSNP
rs943701324 512 dbSNP
rs1352812685 518 dbSNP
rs1446248903 519 dbSNP
rs796068019 524 dbSNP
rs1338166395 525 dbSNP
rs1333142878 526 dbSNP
rs1382431472 527 dbSNP
rs1386200704 529 dbSNP
rs1374374996 531 dbSNP
rs943175258 533 dbSNP
rs1418409081 540 dbSNP
rs1393107244 544 dbSNP
rs181213847 558 dbSNP
rs767371362 563 dbSNP
rs1366797696 569 dbSNP
rs934590012 583 dbSNP
rs1052966801 584 dbSNP
rs1187181034 585 dbSNP
rs185994947 593 dbSNP
rs1032893629 596 dbSNP
rs552252949 598 dbSNP
rs1044433663 599 dbSNP
rs564510346 605 dbSNP
rs1248037678 612 dbSNP
rs1353727474 626 dbSNP
rs1283070385 630 dbSNP
rs777757590 632 dbSNP
rs905928055 639 dbSNP
rs1327757853 642 dbSNP
rs1006077869 646 dbSNP
rs1267307147 664 dbSNP
rs1017094645 668 dbSNP
rs1035616260 669 dbSNP
rs1178698009 675 dbSNP
rs2303506 681 dbSNP
rs994391538 682 dbSNP
rs1029928998 691 dbSNP
rs10445322 698 dbSNP
rs1465360751 707 dbSNP
rs760875258 708 dbSNP
rs1162670589 712 dbSNP
rs919779720 720 dbSNP
rs954333212 720 dbSNP
rs1352595604 729 dbSNP
rs987154388 734 dbSNP
rs1463349093 736 dbSNP
rs557361200 738 dbSNP
rs1477395361 739 dbSNP
rs952565497 740 dbSNP
rs764385191 743 dbSNP
rs982531876 750 dbSNP
rs908294713 752 dbSNP
rs1195826069 755 dbSNP
rs779453808 758 dbSNP
rs1275958309 759 dbSNP
rs964482126 762 dbSNP
rs1217632588 766 dbSNP
rs1384944796 770 dbSNP
rs943707710 779 dbSNP
rs754167190 784 dbSNP
rs1439225960 786 dbSNP
rs190453563 791 dbSNP
rs1040652667 792 dbSNP
rs539781889 799 dbSNP
rs921530561 800 dbSNP
rs925767090 814 dbSNP
rs1168882886 820 dbSNP
rs1465285596 821 dbSNP
rs1429748828 829 dbSNP
rs934495380 831 dbSNP
rs9894355 840 dbSNP
rs1477016261 849 dbSNP
rs1246003718 853 dbSNP
rs183437034 860 dbSNP
rs1054021839 865 dbSNP
rs1205667694 871 dbSNP
rs536478557 872 dbSNP
rs1197644651 879 dbSNP
rs1323719612 887 dbSNP
rs917189605 905 dbSNP
rs1265171055 907 dbSNP
rs1487826204 913 dbSNP
rs1221247583 916 dbSNP
rs1365904407 918 dbSNP
rs893993982 920 dbSNP
rs779270040 924 dbSNP
rs1379283729 932 dbSNP
rs11556499 933 dbSNP
rs1044347589 934 dbSNP
rs1269741547 937 dbSNP
rs905867270 940 dbSNP
rs1477524277 953 dbSNP
rs1191534843 954 dbSNP
rs1421951315 963 dbSNP
rs548252826 967 dbSNP
rs1177990033 969 dbSNP
rs13477 971 dbSNP
rs750764787 992 dbSNP
rs140981103 1003 dbSNP
rs1424203300 1008 dbSNP
rs906582106 1019 dbSNP
rs1441408189 1023 dbSNP
rs1003558596 1024 dbSNP
rs1177425699 1024 dbSNP
rs1461509108 1025 dbSNP
rs1038900055 1028 dbSNP
rs1207551330 1033 dbSNP
rs1170892224 1036 dbSNP
rs780457644 1041 dbSNP
rs1033657263 1054 dbSNP
rs1278344424 1066 dbSNP
rs1224839764 1075 dbSNP
rs897313610 1076 dbSNP
rs994366090 1077 dbSNP
rs1422716982 1092 dbSNP
rs1383583571 1094 dbSNP
rs931385704 1102 dbSNP
rs1366066016 1118 dbSNP
rs1446078312 1126 dbSNP
rs1358380772 1131 dbSNP
rs1398886325 1134 dbSNP
rs747628611 1137 dbSNP
rs769343182 1143 dbSNP
rs1378352901 1149 dbSNP
rs1157953719 1155 dbSNP
rs1363656157 1163 dbSNP
rs142459599 1167 dbSNP
rs1179814608 1169 dbSNP
rs952694888 1178 dbSNP
rs1237269154 1182 dbSNP
rs1217748383 1185 dbSNP
rs1007160308 1187 dbSNP
rs1312543049 1187 dbSNP
rs1240014340 1190 dbSNP
rs1322468651 1197 dbSNP
rs1314874082 1202 dbSNP
rs186256815 1212 dbSNP
rs908305613 1212 dbSNP
rs1270575464 1234 dbSNP
rs1225429312 1236 dbSNP
rs1293167074 1239 dbSNP
rs1358358627 1243 dbSNP
rs576438545 1246 dbSNP
rs1214544058 1251 dbSNP
rs1243857455 1259 dbSNP
rs115562564 1261 dbSNP
rs1033207091 1263 dbSNP
rs1181468382 1264 dbSNP
rs192160159 1266 dbSNP
rs1422912445 1269 dbSNP
rs1419725532 1270 dbSNP
rs770578511 1275 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Disease 58488.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM714644. RNA binding protein: AGO2. Condition:completeT1 ...

- Kishore S; Jaskiewicz L; Burger L; Hausser et al., 2011, Nature methods.

Article - Kishore S; Jaskiewicz L; Burger L; Hausser et al.
- Nature methods, 2011
Cross-linking and immunoprecipitation (CLIP) is increasingly used to map transcriptome-wide binding sites of RNA-binding proteins. We developed a method for CLIP data analysis, and applied it to compare CLIP with photoactivatable ribonucleoside-enhanced CLIP (PAR-CLIP) and to uncover how differences in cross-linking and ribonuclease digestion affect the identified sites. We found only small differences in accuracies of these methods in identifying binding sites of HuR, which binds low-complexity sequences, and Argonaute 2, which has a complex binding specificity. We found that cross-link-induced mutations led to single-nucleotide resolution for both PAR-CLIP and CLIP. Our results confirm the expectation from original CLIP publications that RNA-binding proteins do not protect their binding sites sufficiently under the denaturing conditions used during the CLIP procedure, and we show that extensive digestion with sequence-specific RNases strongly biases the recovered binding sites. This bias can be substantially reduced by milder nuclease digestion conditions.
LinkOut: [PMID: 21572407]
CLIP-seq Support 1 for dataset GSM714644
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / completeT1, repA
Location of target site ENST00000576183.1 | 3UTR | AUCUCAGGGAAAAAUUUUAAUCACUGUGUAUAAUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 21572407 / GSE28865
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
62 hsa-miR-5694 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT078065 PCTP phosphatidylcholine transfer protein 2 2
MIRT088837 MSH6 mutS homolog 6 2 2
MIRT234353 MSL1 male specific lethal 1 homolog 2 8
MIRT342419 B2M beta-2-microglobulin 2 2
MIRT407505 PTMA prothymosin, alpha 2 2
MIRT441745 SSH3 slingshot protein phosphatase 3 2 2
MIRT449899 C11orf34 placenta expressed transcript 1 1 2
MIRT452523 TFDP2 transcription factor Dp-2 2 2
MIRT454862 ACOT9 acyl-CoA thioesterase 9 2 2
MIRT457703 ZNF587 zinc finger protein 587 2 4
MIRT459138 FADS6 fatty acid desaturase 6 2 2
MIRT460127 CXCL16 C-X-C motif chemokine ligand 16 2 2
MIRT473087 MORN4 MORN repeat containing 4 2 2
MIRT478869 CREBRF CREB3 regulatory factor 2 2
MIRT479435 CDKN1B cyclin dependent kinase inhibitor 1B 2 2
MIRT479722 CCNF cyclin F 2 2
MIRT484235 IER2 immediate early response 2 2 2
MIRT491770 ZNF385A zinc finger protein 385A 2 2
MIRT497233 APOL2 apolipoprotein L2 2 2
MIRT500142 POLD3 DNA polymerase delta 3, accessory subunit 2 8
MIRT500597 UBN2 ubinuclein 2 2 10
MIRT502858 CHEK2 checkpoint kinase 2 2 6
MIRT511900 FNBP1L formin binding protein 1 like 2 6
MIRT526061 CBR1 carbonyl reductase 1 2 2
MIRT529068 ZNF675 zinc finger protein 675 2 2
MIRT532845 ZNF699 zinc finger protein 699 2 2
MIRT533257 VCAM1 vascular cell adhesion molecule 1 2 2
MIRT533372 UBE2D4 ubiquitin conjugating enzyme E2 D4 (putative) 2 4
MIRT534669 RNF152 ring finger protein 152 2 2
MIRT539209 ANTXR2 anthrax toxin receptor 2 2 2
MIRT541962 GABPB1 GA binding protein transcription factor beta subunit 1 2 2
MIRT546575 SAR1A secretion associated Ras related GTPase 1A 2 2
MIRT548250 FBXW7 F-box and WD repeat domain containing 7 2 2
MIRT550661 ZFP37 ZFP37 zinc finger protein 2 2
MIRT553776 TAF13 TATA-box binding protein associated factor 13 2 4
MIRT553962 SRSF7 serine and arginine rich splicing factor 7 2 2
MIRT554375 SFPQ splicing factor proline and glutamine rich 2 2
MIRT554979 RAB5C RAB5C, member RAS oncogene family 2 2
MIRT555820 PCDH11Y protocadherin 11 Y-linked 2 4
MIRT557557 GOSR1 golgi SNAP receptor complex member 1 2 2
MIRT559876 ATXN3 ataxin 3 2 2
MIRT561382 TWF1 twinfilin actin binding protein 1 2 2
MIRT567382 GTPBP3 GTP binding protein 3, mitochondrial 2 2
MIRT569271 PCDH11X protocadherin 11 X-linked 2 2
MIRT608549 TBC1D24 TBC1 domain family member 24 2 2
MIRT612839 KCNJ12 potassium voltage-gated channel subfamily J member 12 2 4
MIRT617050 ZNF610 zinc finger protein 610 2 2
MIRT625215 SH3TC2 SH3 domain and tetratricopeptide repeats 2 2 2
MIRT629044 KLLN killin, p53-regulated DNA replication inhibitor 2 2
MIRT645081 UQCRQ ubiquinol-cytochrome c reductase complex III subunit VII 2 2
MIRT651756 VEGFA vascular endothelial growth factor A 2 2
MIRT668027 HAUS3 HAUS augmin like complex subunit 3 2 2
MIRT668467 FAM208A family with sequence similarity 208 member A 2 2
MIRT681917 SLC11A2 solute carrier family 11 member 2 2 2
MIRT687215 PLXNA3 plexin A3 2 2
MIRT690209 C5orf45 MRN complex interacting protein 2 2
MIRT692679 ZMYM1 zinc finger MYM-type containing 1 2 2
MIRT696230 POU2F3 POU class 2 homeobox 3 2 2
MIRT698200 TMEM30A transmembrane protein 30A 2 2
MIRT703726 FAM127A retrotransposon Gag like 8C 2 2
MIRT713459 SLC22A12 solute carrier family 22 member 12 2 2
MIRT725123 SYNRG synergin gamma 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-5694 Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-5694 Cisplatin 5460033 NSC119875 approved sensitive cell line (CP20)
hsa-miR-5694 Cisplatin 5460033 NSC119875 approved sensitive cell line (CIS)
hsa-miR-5694 Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (100 ng/ml)
hsa-miR-5694 Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (1500 ng/ml)

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