miRTarBase - #MIRT078461


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pre-miRNA Information
pre-miRNA hsa-mir-19a   
Genomic Coordinates chr13: 91350891 - 91350972
Synonyms MIRN19A, hsa-mir-19a, miR-19a, miRNA19A, MIR19A
Description Homo sapiens miR-19a stem-loop
Comment This sequence maps to chromosome 13 and is named miR-19a precursor-13 in reference .
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-19a-5p
Sequence 14| AGUUUUGCAUAGUUGCACUACA |35
Evidence Experimental
Experiments Cloned
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs756288295 2 dbSNP
rs1051963210 6 dbSNP
rs780315531 8 dbSNP
rs1162564162 9 dbSNP
rs1170543143 13 dbSNP
rs1388542964 15 dbSNP
rs1442807536 18 dbSNP
rs1403138754 20 dbSNP
rs764765453 21 dbSNP
Putative Targets

miRNA Expression profile
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Biomarker Information
Biomarker ID Name Type Discovered From Mode Level Source Testing Methods
BST0O9 miR-19a Predictive Biomarker (PRD) Clinical/Experimental Data Expression Decrease Tumor tissue Quantitative real-time PCR
Gene Information
Gene Symbol MAP3K3   
Synonyms MAPKKK3, MEKK3
Description mitogen-activated protein kinase kinase kinase 3
Transcript NM_002401   
Other Transcripts NM_203351   
Expression
Putative miRNA Targets on MAP3K3
3'UTR of MAP3K3
(miRNA target sites are highlighted)		 
>MAP3K3|NM_002401|3'UTR
   1 GCTCTCACGGCCACACAGCTGCCGGTCGCCCTTTGCTGCATGGCAGGGGGCTGCTGCTGGGCTCAGTGAAGTTGCTGCTT
  81 CTCCCAGGCAAGGCTGTGGACCATGGAGTGGCAGCCCAGCCAGCGTCGGTCTGTGCCCCTTCCGCCACTGGGGCTCAGAG
 161 CCGGGGTGGGGTGGCTGCAGCCTCAGGACTGGGAGCCCCCAGCCTGTCAGATCCAGGAGCTCCAGTGTCCTGAGCTCAGC
 241 GTGGAGGGGTAGGGGCTGGGAACAGTGTGCAAGGCAGCCGTGGGCCCCACCCTCGGGGATGTGTCCTGACACTGCAATTG
 321 GCACCGAAGCCCAGAGGGTCTGGGGGCACAAGACTGACGCCAGGGTATGAAGAGTGTTATTTTCATTCAAAGTGTTATTT
 401 TGTTTTTCCTTCCAATGTCTGGAGACCACCAGGGCATCTCTGGGCTGGATGAGCTCCCACAAGCCTGAGGGAAAGGCCAG
 481 CACTCGCTAGCAGTGGCAGGCAGAGGCCCAGGCTGCCGTCCCCTAGAGTCCCAGGTTGGCTCTGCCAGTCCTGTCCTTTA
 561 CCAAAGATGAATGAAGCAAATGTCATGCTGCCTTATTCAGGGAAGGAGGAGCCTGTCCTGCCTGTGGCCATGACCCTGCC
 641 TCTCCCAGGCAGGGGCCCGCGATGTGGAACTGCTGCCACTGAGGGGGGATCCAGTTTTGTCAATGCAGTTGTCTCTGTTT
 721 TACAAGTTGGAGTCACTCTTATGCTGTACCCAGTTTCTAAACTGGAGACTGTGTGTGCCCTCTGGGCTCTGAGTACCCCT
 801 GCTTTGGGCTTGGGCCTAGGCTGCATTGAAAAGAGCTGAAGGTTGTGGCCTTTGCGCTCCTGGCCCAGCCTTTGTTCCCC
 881 ACTGGAGCAGAAGGGGAGATGGACGACACGGTCGGGGCATCTGGCCTGGCCAGTGCCCTGATCCCAGAGAGCCCGAGGAG
 961 GTGTCTCAGGCTGCCTGAGTCGTGACCTGCTAGGCCAGAGCCCACTCCATCTGGTAGAAGGGAAAGCCCATATGCTACCA
1041 CCAGCTGTGTCCAAAACCGCCAGCTCTGTTCTTCCTCAGCCAGCCTCGCCCATCCCCTTGAGGTCTCAGCCCCTTTCCCT
1121 TGTAGCTCCTCCCCTGGAGGGGGAATGGCAGCAGGGGTTGGGGAAACAGCATCTCCAAGCAGCTTAGAGTTGGCCATATT
1201 TACCTCAGCCTGGGCGCTGGTCCTTTCTTCCGGCCCCTCCCCTCCAAAATGTGCCTATTGCTAGAGCTCCTCCCTCTCAA
1281 CACCCAGTTTCCTTGGGAGTTGTCATTAAAGGAAAAAAAAAAAAAAAAAAGCCAGTGCCCAGGGATGGGCATCTCCAGGG
1361 AGCTGGGGATTAGTGCCAGGCAGCCCTGCCAGCCATGCCTACATCCCCATGGGCACAGAACAAGCCAAAGCCTTCGTTGT
1441 ATGTTGACGATGCACTTTTATGAATGTAGTTTCTATCGCTGTTTTTAGCCTTTTCACATCATGTAATGTGAGGCCTTGTA
1521 CTTGTTAATTTATATCTCAGATCATATTTGATGGTTTTTATATATATCAATTCTAGACTGTTACAGGTGACGGACGCCTC
1601 AAGAGAGAGAAGAGAAAATGAAAGCAGCTGGTTTTGCAGAAGTGTGTGTCGCATGCGCCAGTTGGGCCTGGACCCTCCTG
1681 TGTCCATCCCTGTTCCCCCAGGGGCTCTATCAGCCCCTGTACCCCACACTGCCCTCTGAAGACAACACAGGCTCCTGCTT
1761 CCACCTCGGCCCTTGCCCAGGGTGGGGCCTGGCCCTCATCTTGACCAAAGCTGCTGTGTGGCAGCTCGGCCTCTCTACGA
1841 CCCCATCTTGGTGGCTGCACACTCTTCCTGGCCCGCACCCCCATCCCCAGTCCCTGTTCCCCAAGAGGATACAGAGCACG
1921 GTGCTGGCTGACTCAACTGTGCGTCCCAGGTTCAGGGTCTTACAGAGCTCCACCCCCTGGGGTCTTACCTCACTGGGAAT
2001 GTGTTTTGAAAATGAATTTGAAGACAAGCCAACAAACCCTGCACTCCAAAAAAGCAAAACAGACCCTAATTTTTTTGTGC
2081 CAAAAACTGTGGACATGCTGGCTCAGCATCCTCAGGACCAAGTTGTTGCTTAATTTATTGTTTTTTAATAACTAATCCAG
2161 ATAAAAAGTTGTGGGGCTTCAGGGTGACCTGGGCCCAAAGGTTCTGAAGGGCAGTTCCTGGCAGCCCCAGGCTTGCTGTG
2241 GGAAGGGGCCGTGCCGTCACTTTCTCATCATTCCATGGGGTGTGTCTGCCTGGGCCAACTCTGCATGGAGAGGCCAGGGC
2321 TGGGGACAGTCCGCACTCTGCCACCCTCCTGCCCCTTCCACCCACCCCAGCTCTATGTCTGTGTCTGAATTGTGGATCGT
2401 GCAGCCATGGTTATTGTGGAACTGTGGAACCTGCAGCCATAGTTATTTGACTATATCTTGACCGAGGGCTTGCAGTGCAA
2481 AGCCAGGCCAGTGTTGCGCATTACTTACAATAAAAGGGATCATTTATATCAGAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' acaUCACGUUGAUACGUUUUGa 5'
             | | |||  | ||||||| 
Target 5' tgcACTCCAAAAAAGCAAAACa 3'
 2040 - 2061 155.00 -6.40
2 
miRNA  3' acaUCACG-UUGAUACGUUUUGa 5'
             || ||  :| :||||||:| 
Target 5' ccgAGGGCTTGCAGTGCAAAGCc 3'
 2462 - 2484 139.00 -10.70
3 
miRNA  3' acaucacGUUGAUAC--GUUUUGa 5'
                 ||:||:||  |||||| 
Target 5' ctaccacCAGCTGTGTCCAAAACc 3'
 1035 - 1058 127.00 -12.30
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN26983655 9 COSMIC
COSN28040683 15 COSMIC
COSN19703995 24 COSMIC
COSN30498960 25 COSMIC
COSN30106591 41 COSMIC
COSN20078757 49 COSMIC
COSN31495286 51 COSMIC
COSN26307847 55 COSMIC
COSN31537982 129 COSMIC
COSN30177087 159 COSMIC
COSN31551285 171 COSMIC
COSN20696029 215 COSMIC
COSN8603600 280 COSMIC
COSN31543857 290 COSMIC
COSN31537983 359 COSMIC
COSN31555057 360 COSMIC
COSN8603601 457 COSMIC
COSN31482920 585 COSMIC
COSN62516 638 COSMIC
COSN26677708 673 COSMIC
COSN29333472 787 COSMIC
COSN31551969 915 COSMIC
COSN30161572 1059 COSMIC
COSN30543302 1101 COSMIC
COSN22923030 1242 COSMIC
COSN26507242 1312 COSMIC
COSN19657799 1313 COSMIC
COSN18770699 1331 COSMIC
COSN29836011 1331 COSMIC
COSN31589378 1437 COSMIC
COSN32154201 1474 COSMIC
COSN25371536 1607 COSMIC
COSN26321673 1688 COSMIC
COSN2521055 1697 COSMIC
COSN22761314 1801 COSMIC
COSN31593418 1829 COSMIC
COSN24759684 1839 COSMIC
COSN31579005 1902 COSMIC
COSN20778228 2000 COSMIC
COSN6109147 2033 COSMIC
COSN31533414 2112 COSMIC
COSN31534328 2204 COSMIC
COSN26552163 2215 COSMIC
COSN4770066 2376 COSMIC
COSN1199709 2388 COSMIC
COSN24306283 2489 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs373679160 2 dbSNP
rs1376188188 7 dbSNP
rs1446445430 8 dbSNP
rs45550042 9 dbSNP
rs759020124 10 dbSNP
rs780677885 12 dbSNP
rs1023713635 18 dbSNP
rs971177100 19 dbSNP
rs1311375495 20 dbSNP
rs1434703820 23 dbSNP
rs747155622 24 dbSNP
rs375158743 25 dbSNP
rs369463266 26 dbSNP
rs147831640 28 dbSNP
rs774148273 29 dbSNP
rs1476271976 34 dbSNP
rs745642617 39 dbSNP
rs1421972199 41 dbSNP
rs756203244 44 dbSNP
rs973628944 50 dbSNP
rs199668197 51 dbSNP
rs1208448708 52 dbSNP
rs932129859 54 dbSNP
rs749482716 57 dbSNP
rs908719502 59 dbSNP
rs941517706 61 dbSNP
rs1287082561 88 dbSNP
rs1233535819 90 dbSNP
rs573570273 99 dbSNP
rs1291892014 109 dbSNP
rs542302618 111 dbSNP
rs996887007 112 dbSNP
rs1291166372 122 dbSNP
rs188571578 125 dbSNP
rs1165674863 126 dbSNP
rs771464819 128 dbSNP
rs141422179 144 dbSNP
rs999420146 146 dbSNP
rs1267507672 157 dbSNP
rs113599770 161 dbSNP
rs1423008852 162 dbSNP
rs771267664 163 dbSNP
rs1452418754 164 dbSNP
rs763626238 168 dbSNP
rs1201210853 169 dbSNP
rs1012033505 170 dbSNP
rs1213764105 171 dbSNP
rs968309782 185 dbSNP
rs1270857047 199 dbSNP
rs545191896 200 dbSNP
rs1327421070 201 dbSNP
rs1183609791 206 dbSNP
rs145320176 208 dbSNP
rs1034048867 215 dbSNP
rs1326742485 221 dbSNP
rs1443160715 225 dbSNP
rs1456051871 231 dbSNP
rs1162916822 239 dbSNP
rs1462656543 240 dbSNP
rs530781711 242 dbSNP
rs1172249802 252 dbSNP
rs1426728917 257 dbSNP
rs1247306560 262 dbSNP
rs1014944327 265 dbSNP
rs959280560 267 dbSNP
rs962020907 275 dbSNP
rs1390767760 280 dbSNP
rs1406770567 281 dbSNP
rs1208874003 283 dbSNP
rs1321147028 293 dbSNP
rs1253510496 295 dbSNP
rs772456755 296 dbSNP
rs1342127927 299 dbSNP
rs544530261 302 dbSNP
rs147562286 318 dbSNP
rs763548643 320 dbSNP
rs529285779 326 dbSNP
rs1392238312 327 dbSNP
rs908945897 334 dbSNP
rs1299703360 338 dbSNP
rs941558766 342 dbSNP
rs149021216 347 dbSNP
rs759162560 359 dbSNP
rs1227647528 360 dbSNP
rs1392739483 368 dbSNP
rs1197535181 375 dbSNP
rs566150269 376 dbSNP
rs923635801 379 dbSNP
rs1260240589 385 dbSNP
rs1194491680 390 dbSNP
rs1482948130 391 dbSNP
rs1281447740 397 dbSNP
rs181499006 399 dbSNP
rs1357092994 409 dbSNP
rs1053671119 414 dbSNP
rs1051318713 419 dbSNP
rs1337802942 421 dbSNP
rs551512374 423 dbSNP
rs143033309 434 dbSNP
rs891150436 450 dbSNP
rs764955159 459 dbSNP
rs1009553165 460 dbSNP
rs1490307916 464 dbSNP
rs1436567000 472 dbSNP
rs1399976720 475 dbSNP
rs1171529056 479 dbSNP
rs537288245 486 dbSNP
rs1012085792 487 dbSNP
rs761430030 488 dbSNP
rs1471910536 490 dbSNP
rs1179612314 491 dbSNP
rs1182041743 492 dbSNP
rs903931171 493 dbSNP
rs111454356 495 dbSNP
rs1161159457 496 dbSNP
rs906336386 498 dbSNP
rs1484998250 508 dbSNP
rs1003655383 517 dbSNP
rs1033478394 519 dbSNP
rs1389556937 521 dbSNP
rs1352971548 529 dbSNP
rs1258969635 532 dbSNP
rs750177517 536 dbSNP
rs1356322225 540 dbSNP
rs1293751193 550 dbSNP
rs1416361149 553 dbSNP
rs1015414245 557 dbSNP
rs897866817 566 dbSNP
rs762578136 571 dbSNP
rs1309633924 581 dbSNP
rs1368413870 589 dbSNP
rs959166518 590 dbSNP
rs1013471569 591 dbSNP
rs1024827094 592 dbSNP
rs1409167919 592 dbSNP
rs1386531870 597 dbSNP
rs1479093711 609 dbSNP
rs1156251636 613 dbSNP
rs950462020 614 dbSNP
rs1190591642 617 dbSNP
rs1472023820 624 dbSNP
rs1237198349 629 dbSNP
rs994841532 630 dbSNP
rs1449188906 640 dbSNP
rs1259802047 641 dbSNP
rs1208152469 646 dbSNP
rs567889306 648 dbSNP
rs1335815004 656 dbSNP
rs140222424 659 dbSNP
rs368096233 660 dbSNP
rs963159897 661 dbSNP
rs1328101954 662 dbSNP
rs974863872 673 dbSNP
rs1282435537 679 dbSNP
rs1359015251 683 dbSNP
rs1433699263 683 dbSNP
rs1166655902 686 dbSNP
rs56379166 694 dbSNP
rs932782596 702 dbSNP
rs966595941 714 dbSNP
rs976564362 716 dbSNP
rs538743267 718 dbSNP
rs558746859 731 dbSNP
rs945403251 733 dbSNP
rs1188069795 741 dbSNP
rs1468975089 742 dbSNP
rs935045237 743 dbSNP
rs1257470437 751 dbSNP
rs1219680532 760 dbSNP
rs1451200399 768 dbSNP
rs1443703825 770 dbSNP
rs1184780680 771 dbSNP
rs989116239 772 dbSNP
rs1341461561 777 dbSNP
rs575503847 779 dbSNP
rs914881739 785 dbSNP
rs751513633 788 dbSNP
rs1295338059 790 dbSNP
rs1449718951 792 dbSNP
rs751463902 797 dbSNP
rs1042390149 799 dbSNP
rs948016081 827 dbSNP
rs756295317 830 dbSNP
rs1170050953 831 dbSNP
rs936780036 834 dbSNP
rs866980635 856 dbSNP
rs777970649 857 dbSNP
rs757202721 858 dbSNP
rs1330051782 860 dbSNP
rs1411987693 872 dbSNP
rs1428841903 873 dbSNP
rs906396366 878 dbSNP
rs544465033 879 dbSNP
rs561215005 881 dbSNP
rs990198767 882 dbSNP
rs895004002 897 dbSNP
rs575077101 898 dbSNP
rs1024879708 900 dbSNP
rs767262754 904 dbSNP
rs574679615 905 dbSNP
rs150451034 906 dbSNP
rs542979180 910 dbSNP
rs1272166863 911 dbSNP
rs1015939093 912 dbSNP
rs15637 914 dbSNP
rs746227242 915 dbSNP
rs974508123 930 dbSNP
rs1279784297 935 dbSNP
rs772426990 939 dbSNP
rs541403321 955 dbSNP
rs954223447 956 dbSNP
rs747479854 960 dbSNP
rs912858982 964 dbSNP
rs966278378 974 dbSNP
rs551452522 982 dbSNP
rs978716756 983 dbSNP
rs755861555 993 dbSNP
rs1464929878 1003 dbSNP
rs1249411609 1005 dbSNP
rs1181151950 1011 dbSNP
rs1031768477 1012 dbSNP
rs1485997186 1018 dbSNP
rs1257676407 1019 dbSNP
rs1207861516 1031 dbSNP
rs1311107118 1034 dbSNP
rs1284298455 1040 dbSNP
rs1229874407 1050 dbSNP
rs113641709 1053 dbSNP
rs150772654 1057 dbSNP
rs185467883 1057 dbSNP
rs530984747 1059 dbSNP
rs1245803471 1060 dbSNP
rs1055163108 1062 dbSNP
rs895224521 1064 dbSNP
rs1415773428 1069 dbSNP
rs1427487455 1075 dbSNP
rs550926327 1078 dbSNP
rs1465947833 1085 dbSNP
rs1345885278 1088 dbSNP
rs989166959 1089 dbSNP
rs914934135 1090 dbSNP
rs947699882 1093 dbSNP
rs779128848 1097 dbSNP
rs1464511779 1098 dbSNP
rs1171899673 1103 dbSNP
rs1405507379 1104 dbSNP
rs886235712 1111 dbSNP
rs375081825 1116 dbSNP
rs1180075687 1120 dbSNP
rs980751147 1129 dbSNP
rs567913878 1132 dbSNP
rs1016571056 1134 dbSNP
rs939249278 1140 dbSNP
rs1210019642 1154 dbSNP
rs1267120782 1158 dbSNP
rs1326715425 1158 dbSNP
rs1036209694 1159 dbSNP
rs1323912906 1164 dbSNP
rs897636433 1171 dbSNP
rs930736003 1176 dbSNP
rs1310971084 1185 dbSNP
rs1396011419 1188 dbSNP
rs1363236954 1191 dbSNP
rs768202063 1193 dbSNP
rs1432975963 1196 dbSNP
rs1387923809 1202 dbSNP
rs1165930492 1206 dbSNP
rs1463172477 1212 dbSNP
rs190289443 1216 dbSNP
rs1162401596 1218 dbSNP
rs889154787 1223 dbSNP
rs1423212579 1224 dbSNP
rs11653941 1228 dbSNP
rs776101395 1232 dbSNP
rs1381802872 1233 dbSNP
rs768395090 1236 dbSNP
rs1040337806 1237 dbSNP
rs902103224 1241 dbSNP
rs1333147234 1254 dbSNP
rs1489246766 1264 dbSNP
rs1231754186 1267 dbSNP
rs987180626 1268 dbSNP
rs1019788880 1269 dbSNP
rs1308661877 1270 dbSNP
rs1300464412 1275 dbSNP
rs999036532 1282 dbSNP
rs1364586215 1295 dbSNP
rs1326600987 1298 dbSNP
rs1388793225 1300 dbSNP
rs1388805385 1301 dbSNP
rs1263037550 1303 dbSNP
rs1329313133 1308 dbSNP
rs1210051261 1311 dbSNP
rs1265633682 1312 dbSNP
rs1203660981 1313 dbSNP
rs1247394258 1313 dbSNP
rs1389070810 1313 dbSNP
rs1434614339 1313 dbSNP
rs1435166338 1313 dbSNP
rs1481166937 1313 dbSNP
rs200804576 1313 dbSNP
rs34163987 1313 dbSNP
rs546095896 1313 dbSNP
rs755763179 1313 dbSNP
rs1485353966 1314 dbSNP
rs1191375176 1315 dbSNP
rs1235507024 1321 dbSNP
rs1269251750 1332 dbSNP
rs978387665 1333 dbSNP
rs1198680487 1334 dbSNP
rs1031819313 1344 dbSNP
rs1412621643 1364 dbSNP
rs1392143399 1365 dbSNP
rs957516929 1368 dbSNP
rs370632620 1374 dbSNP
rs1427791296 1380 dbSNP
rs914552443 1381 dbSNP
rs566486410 1385 dbSNP
rs969124494 1387 dbSNP
rs1386476918 1393 dbSNP
rs916540462 1400 dbSNP
rs1419252230 1406 dbSNP
rs1254475806 1407 dbSNP
rs538681305 1410 dbSNP
rs907718615 1411 dbSNP
rs1281646609 1419 dbSNP
rs1202637705 1436 dbSNP
rs769441109 1437 dbSNP
rs1393392463 1447 dbSNP
rs558683342 1449 dbSNP
rs1037652781 1450 dbSNP
rs1283285507 1461 dbSNP
rs1290055763 1465 dbSNP
rs960925849 1466 dbSNP
rs1351658295 1467 dbSNP
rs1407754004 1469 dbSNP
rs899070688 1473 dbSNP
rs558774221 1479 dbSNP
rs575439731 1482 dbSNP
rs1399464110 1485 dbSNP
rs1050092623 1490 dbSNP
rs1457478160 1492 dbSNP
rs1315781455 1497 dbSNP
rs1221914443 1501 dbSNP
rs1157475811 1519 dbSNP
rs919118393 1520 dbSNP
rs1472474035 1521 dbSNP
rs1266834348 1522 dbSNP
rs1190255701 1525 dbSNP
rs1441173575 1536 dbSNP
rs890093254 1537 dbSNP
rs1205790390 1539 dbSNP
rs1331567188 1540 dbSNP
rs1266488654 1545 dbSNP
rs538029873 1549 dbSNP
rs930453119 1556 dbSNP
rs1020432784 1559 dbSNP
rs554484166 1559 dbSNP
rs1246961658 1561 dbSNP
rs1473542903 1571 dbSNP
rs1333002598 1573 dbSNP
rs1435167638 1579 dbSNP
rs138443735 1585 dbSNP
rs943434994 1592 dbSNP
rs1415041806 1593 dbSNP
rs540163940 1596 dbSNP
rs1472136668 1597 dbSNP
rs1165826393 1598 dbSNP
rs1189709424 1601 dbSNP
rs753340348 1601 dbSNP
rs1466315079 1605 dbSNP
rs916592689 1606 dbSNP
rs182259791 1618 dbSNP
rs1208368016 1626 dbSNP
rs970677675 1639 dbSNP
rs1290379269 1643 dbSNP
rs1040793314 1651 dbSNP
rs187309038 1652 dbSNP
rs1046229 1656 dbSNP
rs999087112 1657 dbSNP
rs1053287910 1658 dbSNP
rs189674375 1662 dbSNP
rs766156318 1666 dbSNP
rs374872710 1668 dbSNP
rs1294741802 1674 dbSNP
rs1011702707 1679 dbSNP
rs1433961479 1687 dbSNP
rs967311563 1695 dbSNP
rs931894383 1702 dbSNP
rs751493085 1707 dbSNP
rs565020335 1708 dbSNP
rs530925416 1710 dbSNP
rs890145664 1711 dbSNP
rs1008550895 1712 dbSNP
rs1041499571 1718 dbSNP
rs1314155573 1719 dbSNP
rs1319561635 1720 dbSNP
rs1046230 1723 dbSNP
rs999906216 1729 dbSNP
rs1275130217 1740 dbSNP
rs1449654978 1745 dbSNP
rs1032929656 1755 dbSNP
rs958169706 1768 dbSNP
rs1202999339 1769 dbSNP
rs1012469905 1771 dbSNP
rs969557280 1772 dbSNP
rs1001936756 1777 dbSNP
rs1353422997 1778 dbSNP
rs748311399 1780 dbSNP
rs1276254025 1790 dbSNP
rs1433808180 1790 dbSNP
rs1330908887 1793 dbSNP
rs1432210923 1795 dbSNP
rs1035120510 1798 dbSNP
rs1369240358 1799 dbSNP
rs970731559 1814 dbSNP
rs1415119441 1815 dbSNP
rs960386952 1819 dbSNP
rs1427272224 1824 dbSNP
rs1189724688 1825 dbSNP
rs972008073 1827 dbSNP
rs919172139 1828 dbSNP
rs951906062 1829 dbSNP
rs1182525673 1831 dbSNP
rs1477792132 1834 dbSNP
rs1267971798 1835 dbSNP
rs1182627834 1836 dbSNP
rs1415991480 1839 dbSNP
rs1272411689 1840 dbSNP
rs377337270 1843 dbSNP
rs1312297559 1862 dbSNP
rs910360248 1865 dbSNP
rs758477792 1875 dbSNP
rs1322360775 1876 dbSNP
rs1431999025 1879 dbSNP
rs1040442724 1882 dbSNP
rs561328019 1883 dbSNP
rs934655755 1888 dbSNP
rs1449318579 1890 dbSNP
rs530380287 1894 dbSNP
rs920440999 1895 dbSNP
rs772555456 1900 dbSNP
rs1449340461 1901 dbSNP
rs1360988592 1908 dbSNP
rs893396842 1916 dbSNP
rs947610130 1920 dbSNP
rs546971685 1921 dbSNP
rs1473453369 1925 dbSNP
rs906013073 1927 dbSNP
rs1249298653 1931 dbSNP
rs944424468 1939 dbSNP
rs1002389124 1941 dbSNP
rs1483524856 1943 dbSNP
rs1041777266 1944 dbSNP
rs1451517692 1950 dbSNP
rs1207406113 1957 dbSNP
rs567220792 1958 dbSNP
rs1344122315 1962 dbSNP
rs538616546 1964 dbSNP
rs1054185460 1969 dbSNP
rs773527166 1972 dbSNP
rs1327559845 1973 dbSNP
rs993164523 1975 dbSNP
rs1306673879 1977 dbSNP
rs1229440532 1979 dbSNP
rs1381966909 1982 dbSNP
rs893999579 1983 dbSNP
rs1312715155 1987 dbSNP
rs1447417198 1987 dbSNP
rs1025953919 1998 dbSNP
rs1012355611 2000 dbSNP
rs1409548651 2001 dbSNP
rs1158067096 2014 dbSNP
rs77562968 2022 dbSNP
rs1460018502 2029 dbSNP
rs1415856908 2040 dbSNP
rs559744845 2041 dbSNP
rs146138584 2060 dbSNP
rs1248873392 2061 dbSNP
rs1248055767 2062 dbSNP
rs180918043 2076 dbSNP
rs1003759883 2082 dbSNP
rs1166527275 2085 dbSNP
rs1222757790 2088 dbSNP
rs1260544293 2088 dbSNP
rs1015347239 2090 dbSNP
rs1415582680 2096 dbSNP
rs753964127 2098 dbSNP
rs1245833433 2099 dbSNP
rs757343056 2107 dbSNP
rs1366049640 2109 dbSNP
rs1299893189 2112 dbSNP
rs1178835200 2115 dbSNP
rs1384518515 2118 dbSNP
rs923379290 2121 dbSNP
rs1046232 2126 dbSNP
rs1458231574 2146 dbSNP
rs973915393 2147 dbSNP
rs1162629580 2156 dbSNP
rs200666716 2163 dbSNP
rs1390299400 2178 dbSNP
rs1189901106 2179 dbSNP
rs779021083 2183 dbSNP
rs1468822746 2186 dbSNP
rs934710972 2186 dbSNP
rs1320894629 2187 dbSNP
rs1366923800 2188 dbSNP
rs953223326 2193 dbSNP
rs750611728 2199 dbSNP
rs911853760 2202 dbSNP
rs914551252 2206 dbSNP
rs1263996043 2208 dbSNP
rs947662649 2217 dbSNP
rs1368001821 2218 dbSNP
rs1343462162 2219 dbSNP
rs1276945421 2225 dbSNP
rs944626055 2226 dbSNP
rs770948105 2228 dbSNP
rs758723781 2231 dbSNP
rs11558523 2232 dbSNP
rs935661194 2233 dbSNP
rs1369487430 2234 dbSNP
rs1321580752 2239 dbSNP
rs1423978980 2245 dbSNP
rs1057473434 2247 dbSNP
rs896246606 2248 dbSNP
rs1203115205 2250 dbSNP
rs1054161072 2251 dbSNP
rs185670272 2252 dbSNP
rs1026006394 2256 dbSNP
rs1191257217 2257 dbSNP
rs1199144705 2259 dbSNP
rs1483700466 2261 dbSNP
rs906669437 2267 dbSNP
rs568152264 2268 dbSNP
rs1338860800 2270 dbSNP
rs1256608641 2273 dbSNP
rs534039546 2274 dbSNP
rs1310628658 2276 dbSNP
rs1006580147 2281 dbSNP
rs1015153753 2283 dbSNP
rs1478549878 2289 dbSNP
rs1017514570 2290 dbSNP
rs897845948 2291 dbSNP
rs1427813438 2296 dbSNP
rs1395206858 2299 dbSNP
rs542511813 2308 dbSNP
rs1172624152 2314 dbSNP
rs1480358863 2319 dbSNP
rs964942378 2324 dbSNP
rs1175191862 2331 dbSNP
rs1390141154 2332 dbSNP
rs553626366 2333 dbSNP
rs1030091819 2334 dbSNP
rs956142162 2336 dbSNP
rs1317166877 2342 dbSNP
rs746254307 2346 dbSNP
rs1202241496 2348 dbSNP
rs988836985 2352 dbSNP
rs1262760437 2362 dbSNP
rs914603734 2373 dbSNP
rs201666054 2374 dbSNP
rs947380530 2374 dbSNP
rs980798866 2376 dbSNP
rs1438339229 2378 dbSNP
rs16421 2380 dbSNP
rs3833117 2380 dbSNP
rs953442720 2380 dbSNP
rs867730684 2382 dbSNP
rs1018801297 2391 dbSNP
rs190431118 2393 dbSNP
rs1397281732 2397 dbSNP
rs1403180431 2399 dbSNP
rs938896516 2406 dbSNP
rs924537945 2414 dbSNP
rs1414711081 2418 dbSNP
rs1228876692 2425 dbSNP
rs746807838 2442 dbSNP
rs1289097840 2443 dbSNP
rs1470130212 2444 dbSNP
rs1369535665 2447 dbSNP
rs1190144501 2452 dbSNP
rs1442892737 2464 dbSNP
rs1242563059 2465 dbSNP
rs1209655173 2478 dbSNP
rs572122854 2479 dbSNP
rs989772079 2485 dbSNP
rs1057314295 2498 dbSNP
rs918737385 2499 dbSNP
rs929066679 2500 dbSNP
rs544965599 2501 dbSNP
rs771133315 2501 dbSNP
rs928142411 2503 dbSNP
rs1452618186 2506 dbSNP
rs558548531 2527 dbSNP
rs887476515 2529 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Disease 4215.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM714644. RNA binding protein: AGO2. Condition:completeT1 ...

- Kishore S; Jaskiewicz L; Burger L; Hausser et al., 2011, Nature methods.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' acAUCACGUUGAUACG--UUUUGa 5'
            || | :  :|:|||  ||||| 
Target 5' ccUAAUUUUUUUGUGCCAAAAACu 3'
 		11 - 34
Article - Kishore S; Jaskiewicz L; Burger L; Hausser et al.
- Nature methods, 2011
Cross-linking and immunoprecipitation (CLIP) is increasingly used to map transcriptome-wide binding sites of RNA-binding proteins. We developed a method for CLIP data analysis, and applied it to compare CLIP with photoactivatable ribonucleoside-enhanced CLIP (PAR-CLIP) and to uncover how differences in cross-linking and ribonuclease digestion affect the identified sites. We found only small differences in accuracies of these methods in identifying binding sites of HuR, which binds low-complexity sequences, and Argonaute 2, which has a complex binding specificity. We found that cross-link-induced mutations led to single-nucleotide resolution for both PAR-CLIP and CLIP. Our results confirm the expectation from original CLIP publications that RNA-binding proteins do not protect their binding sites sufficiently under the denaturing conditions used during the CLIP procedure, and we show that extensive digestion with sequence-specific RNases strongly biases the recovered binding sites. This bias can be substantially reduced by milder nuclease digestion conditions.
LinkOut: [PMID: 21572407]
CLIP-seq Support 1 for dataset GSM714644
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / completeT1, repA
Location of target site ENST00000361357.3 | 3UTR | CAAAACAGACCCUAAUUUUUUUGUGCCAAAAACUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 21572407 / GSE28865
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE32688 Pancreatic cancer -0.459 4.1e-3 -0.430 7.0e-3 32 Click to see details
GSE38974 Chronic obstructive pulmonary disease -0.403 2.3e-2 -0.670 1.2e-4 25 Click to see details
GSE28260 Renal cortex and medulla 0.556 2.4e-2 0.544 2.7e-2 13 Click to see details
GSE19350 CNS germ cell tumors 0.536 3.6e-2 0.573 2.6e-2 12 Click to see details
GSE28544 Breast cancer -0.369 3.8e-2 -0.391 2.9e-2 24 Click to see details
GSE42095 Differentiated embryonic stem cells -0.361 4.5e-2 -0.388 3.4e-2 23 Click to see details
GSE21687 Ependynoma primary tumors -0.17 9.0e-2 -0.159 1.0e-1 64 Click to see details
GSE35602 Colorectal cancer stromal tissue -0.176 2.0e-1 0.385 2.9e-2 25 Click to see details
GSE17498 Multiple myeloma -0.071 3.3e-1 -0.232 7.5e-2 40 Click to see details
GSE26953 Aortic valvular endothelial cells 0.081 3.5e-1 0.256 1.1e-1 24 Click to see details
GSE15076 Monocyte-derived dendritic cells 0.237 3.8e-1 0.400 3.0e-1 4 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis 0.059 4.0e-1 0.305 9.6e-2 20 Click to see details
GSE38226 Liver fibrosis 0.024 4.6e-1 -0.158 2.5e-1 21 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
UCEC -0.977 0.07 -1.000 0.5 3 Click to see details
LIHC 0.648 0.18 0.400 0.3 4 Click to see details
LIHC 0.648 0.18 0.400 0.3 4 Click to see details
LIHC 0.648 0.18 0.400 0.3 4 Click to see details
LIHC 0.648 0.18 0.400 0.3 4 Click to see details
LIHC 0.648 0.18 0.400 0.3 4 Click to see details
92 hsa-miR-19a-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT038980 WDR96 cilia and flagella associated protein 43 1 1
MIRT063864 RASSF8 Ras association domain family member 8 2 6
MIRT077656 IGF2BP1 insulin like growth factor 2 mRNA binding protein 1 2 2
MIRT078461 MAP3K3 mitogen-activated protein kinase kinase kinase 3 2 2
MIRT095248 FAM13B family with sequence similarity 13 member B 2 2
MIRT109490 KLHL15 kelch like family member 15 2 6
MIRT155378 CCNT2 cyclin T2 2 2
MIRT163208 EDEM1 ER degradation enhancing alpha-mannosidase like protein 1 2 2
MIRT188326 ARID1A AT-rich interaction domain 1A 2 2
MIRT204723 BZW1 basic leucine zipper and W2 domains 1 2 4
MIRT236399 HMGXB4 HMG-box containing 4 2 2
MIRT237114 P2RY1 purinergic receptor P2Y1 2 5
MIRT286942 SOCS7 suppressor of cytokine signaling 7 2 2
MIRT442523 MOB3B MOB kinase activator 3B 2 2
MIRT473428 MDM4 MDM4, p53 regulator 2 2
MIRT476783 FOS Fos proto-oncogene, AP-1 transcription factor subunit 2 2
MIRT476942 FAM83G family with sequence similarity 83 member G 2 2
MIRT480184 CALM2 calmodulin 2 2 6
MIRT489620 ZNF384 zinc finger protein 384 2 2
MIRT492246 SLC39A9 solute carrier family 39 member 9 2 2
MIRT492422 RGL2 ral guanine nucleotide dissociation stimulator like 2 2 2
MIRT494860 ZNF99 zinc finger protein 99 2 2
MIRT497001 SNAP25 synaptosome associated protein 25 2 2
MIRT501973 MAPK6 mitogen-activated protein kinase 6 2 2
MIRT504917 CD38 CD38 molecule 2 4
MIRT507019 HMGA2 high mobility group AT-hook 2 2 6
MIRT510820 SBNO1 strawberry notch homolog 1 2 4
MIRT514166 PGPEP1 pyroglutamyl-peptidase I 2 2
MIRT514328 PSMG2 proteasome assembly chaperone 2 2 4
MIRT514429 SLC38A7 solute carrier family 38 member 7 2 2
MIRT514537 ESR2 estrogen receptor 2 2 2
MIRT516117 SRPX2 sushi repeat containing protein, X-linked 2 2 4
MIRT517759 ZNF366 zinc finger protein 366 2 4
MIRT518495 FAM161B family with sequence similarity 161 member B 2 4
MIRT518512 CASP10 caspase 10 2 2
MIRT518561 GDPD1 glycerophosphodiester phosphodiesterase domain containing 1 2 2
MIRT518641 NOM1 nucleolar protein with MIF4G domain 1 2 2
MIRT518729 ABCG8 ATP binding cassette subfamily G member 8 2 2
MIRT523565 GGCX gamma-glutamyl carboxylase 2 4
MIRT526523 YIPF6 Yip1 domain family member 6 2 2
MIRT530254 ZNF620 zinc finger protein 620 2 2
MIRT531658 ZFP14 ZFP14 zinc finger protein 2 2
MIRT532699 TCN2 transcobalamin 2 2 4
MIRT534019 STXBP4 syntaxin binding protein 4 2 2
MIRT535748 MYO10 myosin X 2 4
MIRT544509 GTF2E2 general transcription factor IIE subunit 2 2 2
MIRT546758 RLIM ring finger protein, LIM domain interacting 2 2
MIRT547929 HNRNPR heterogeneous nuclear ribonucleoprotein R 2 2
MIRT550130 ZNF138 zinc finger protein 138 2 2
MIRT551763 MED21 mediator complex subunit 21 2 2
MIRT557727 FYCO1 FYVE and coiled-coil domain containing 1 2 2
MIRT558924 CBX1 chromobox 1 2 2
MIRT562466 CORO1C coronin 1C 2 2
MIRT562759 ZNF846 zinc finger protein 846 2 2
MIRT563061 ZNF28 zinc finger protein 28 2 2
MIRT563336 RPLP0 ribosomal protein lateral stalk subunit P0 2 2
MIRT569170 DMD dystrophin 2 2
MIRT573256 TNFAIP6 TNF alpha induced protein 6 2 2
MIRT575057 P2ry1 purinergic receptor P2Y, G-protein coupled 1 2 4
MIRT575360 Zxda zinc finger, X-linked, duplicated A 2 2
MIRT613233 CCDC39 coiled-coil domain containing 39 2 2
MIRT613347 ADRBK2 G protein-coupled receptor kinase 3 2 6
MIRT613952 TMEM59 transmembrane protein 59 2 2
MIRT615488 EDN1 endothelin 1 2 2
MIRT618710 ESD esterase D 2 2
MIRT630609 ARHGAP1 Rho GTPase activating protein 1 2 2
MIRT630619 CXCR6 C-X-C motif chemokine receptor 6 2 2
MIRT630631 IMPAD1 inositol monophosphatase domain containing 1 2 2
MIRT630674 KLF7 Kruppel like factor 7 2 2
MIRT630746 COG6 component of oligomeric golgi complex 6 2 2
MIRT636853 ZSCAN2 zinc finger and SCAN domain containing 2 2 2
MIRT638642 GPATCH8 G-patch domain containing 8 2 2
MIRT639106 MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 2 2
MIRT639422 PKP1 plakophilin 1 2 2
MIRT640187 ABCC12 ATP binding cassette subfamily C member 12 2 2
MIRT641757 SF3A1 splicing factor 3a subunit 1 2 2
MIRT666577 RHOBTB3 Rho related BTB domain containing 3 2 2
MIRT672166 FANCF Fanconi anemia complementation group F 2 2
MIRT688345 ETS1 ETS proto-oncogene 1, transcription factor 2 2
MIRT690120 ZFAND1 zinc finger AN1-type containing 1 2 2
MIRT696939 CERK ceramide kinase 2 2
MIRT701361 NR4A3 nuclear receptor subfamily 4 group A member 3 2 2
MIRT703288 GID4 GID complex subunit 4 homolog 2 2
MIRT709146 ZNF799 zinc finger protein 799 2 2
MIRT710848 FAM210A family with sequence similarity 210 member A 2 2
MIRT712621 GTF2H5 general transcription factor IIH subunit 5 2 2
MIRT714591 CMBL carboxymethylenebutenolidase homolog 2 2
MIRT716909 CACNB2 calcium voltage-gated channel auxiliary subunit beta 2 2 2
MIRT721165 FAM200B family with sequence similarity 200 member B 2 2
MIRT722404 BCAS2 BCAS2, pre-mRNA processing factor 2 2
MIRT722517 DSTYK dual serine/threonine and tyrosine protein kinase 2 2
MIRT724599 AP3B1 adaptor related protein complex 3 beta 1 subunit 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-19a Hydroxamic acid HDACi LAQ824 NULL NULL Microarray breast cancer cell line SKBr3 16452179 2006 down-regulated
miR-19a 5-Fluorouracil approved 3385 Quantitative real-time PCR colon cancer cells 17702597 2007 up-regulated
miR-19a Curcumin NULL 969516 Microarray BxPC-3 human pancreatic carcinoma cell line 18347134 2008 down-regulated
miR-19a 5-aza-2'-deoxycytidine (5-Aza-CdR) approved 451668 Microarray Pancreatic Cancer MiaPACA-2 cells 19407485 2009 up-regulated
miR-19a 5-aza-2'-deoxycytidine (5-Aza-CdR) + trichostatin A(TSA) NULL NULL Microarray Pancreatic Cancer MiaPACA-2 cells 19407485 2009 up-regulated
miR-19a Trichostatin A (TSA) NULL 444732 Microarray Pancreatic Cancer MiaPACA-2 cells 19407485 2009 up-regulated
miR-19a Histone deacetylase inhibitor ITF2357 NULL 9804992 Quantitative real-time PCR multiple myeloma 19713220 2009 down-regulated
miR-19a Activin A NULL 229455 Quantitative real-time PCR Human embryonic stem (hES) cells 19885849 2010 up-regulated
miR-19a Arsenic trioxide approved 14888 Quantitative real-time PCR bladder cancer cell line T24 20857258 2011 down-regulated
miR-19a Ibandronate approved 60852 Quantitative real-time PCR Periodontal ligament stem cells (PDLSCs) 21108928 2011 down-regulated
miR-19a Formaldehyde NULL 712 Microarray Human lung epithelial cells (A549) 21147603 2011 down-regulated
miR-19a 5-azacytidine (5-AzaC) approved 9444 Quantitative real-time PCR chronic myeloid leukemia (CML)K562 cell line 21176349 2011 down-regulated
miR-19a Arsenic trioxide approved 14888 Quantitative real-time PCR acute promyelocytic leukemia 22072212 2012 up-regulated
miR-19a 1,2,6-Tri-O-galloyl-beta-D-glucopyranose NULL NULL Microarray HepG2 hepatocarcinoma cells. 22506400 2011 down-regulated
miR-19a Vitamin D3 approved 5280795 Quantitative real-time PCR Plasma 22594500 2012 down-regulated
miR-19a (S)-3,5-dihydroxyphenylglycine (DHPG) NULL 443586 Quantitative real-time PCR mouse brain 22309833 2012 down-regulated
miR-19a Dexamethasone approved 5743 Microarray primary rat thymocytes 20847043 2010 down-regulated
miR-19a Isoproterenol approved 3779 Quantitative real-time PCR heart 22847192 2012 up-regulated
miR-19a Dexamethasone approved 5743 Quantitative real-time PCR adrenals and granulosa cells 24205079 2014 down-regulated
miR-19a Arsenic trioxide approved 14888 Microarray bladder cancer cell line T24 20857258 2011 down-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-19a Paclitaxel 36314 NSC125973 approved sensitive cell line (A2780)
hsa-miR-19a-5p Imatinib 5291 NSC743414 approved sensitive High Chronic Myelogenous Leukemia cell line (K562)
hsa-miR-19a-5p Fluorouracil 3385 NSC19893 approved resistant Low Colorectal Cancer cell line (HCT-8)
hsa-miR-19a-5p Oxaliplatin 6857599 NSC266046 approved sensitive Low Colorectal Cancer cell line (SW480)
hsa-miR-19a-5p Vemurafenib 42611257 NSC761431 approved resistant cell line (451Lu)
hsa-miR-19a-5p Cisplatin 5460033 NSC119875 approved resistant cell line (A549)
hsa-miR-19a-5p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-19a-5p Sunitinib 5329102 NSC750690 approved resistant tissue (CardB)
hsa-miR-19a-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-19a-5p Ceritinib 57379345 NSC776422 approved sensitive cell line (H3122)

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