miRTarBase - #MIRT080216


—
pre-miRNA Information
pre-miRNA hsa-mir-4526   
Genomic Coordinates chr18: 13611114 - 13611200
Description Homo sapiens miR-4526 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4526
Sequence 54| GCUGACAGCAGGGCUGGCCGCU |75
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1418307303 1 dbSNP
rs1168108556 5 dbSNP
rs1050044717 6 dbSNP
rs1250280154 7 dbSNP
rs370878033 10 dbSNP
rs1008988805 19 dbSNP
rs536331678 20 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol PRKACB   
Synonyms PKA C-beta, PKACB
Description protein kinase cAMP-activated catalytic subunit beta
Transcript NM_002731   
Other Transcripts NM_182948 , NM_207578   
Expression
Putative miRNA Targets on PRKACB
3'UTR of PRKACB
(miRNA target sites are highlighted)		 
>PRKACB|NM_002731|3'UTR
   1 AGAGGAACAAGATGACATCTGAGCTCACACTCAGTGTTTGCACTCTGTTGAGAGATAAGGTAGAGCTGAGACCGTCCTTG
  81 TTGAAGCAGTTACCTAGTTCCTTCATTCCAACGACTGAGTGAGGTCTTTATTGCCATCATCCCGTGTGCGCACTCTGCAT
 161 CCACCTATGTAACAAGGCACCGCTAAGCAAGCATTGTCTGTGCCATAACACAGTACTAGACCACTTTCTTACTTCTCTTT
 241 GGGTTGTCTTTCTCCTCTCCTATATCCATTTCTTCCTTTTCCAATTTCATTGGTTTTCTCTAAACAGTGCTCCATTTTAT
 321 TTTGTTGGTGTTTCAGATGGGCAGTGTTATGGCTACGTGATATTTGAAGGGAAGGATAAGTGTTGCTTTCAGTAGTTATT
 401 GCCAATATTGTTGTTGGTCAATGGCTTGAAGATAAACTTTCTAATAATTATTATTTCTTTGAGTAGCTCAGACTTGGTTT
 481 TGCCAAAACTCTTGGTAATTTTTGAAGATAGACTGTCTTATCACCAAGGAAATTTATACAAATTAAGACTAACTTTCTTG
 561 GAATTCACTATTCTGGCAATAAATTTTGGTAGACTAATACAGTACAGCTAGACCCAGAAATTTGGAAGGCTGTAGATCAG
 641 AGGTTCTAGTTCCCTTTCCCTCCTTTTATATCCTCCTCTCCTTGAGTAATGAAGTGACCAGCCTGTGTAGTGTGACAAAC
 721 GTGTCTCATTCAGCAGGAAAAACTAATGATATGGATCATCACCCAGATTCTCTCACTTGGTACCAGCATTTCTGTAGGTA
 801 TTAGAGAAGAGTTCTAAGTTTTCTAAACCTTAACTGTTCCTTAAGGATTTTAGCCAGTATTTTAATAGAACATGATTAAT
 881 GAAAGTGACAAATTTTAAATTTTCTCTAATAGTCCTCATCATAAACTTTTTAAAGGAAAATAAGCAAACTAAAAAGAACA
 961 TTGGTTTAGATAAATACTTATACTTTGCAAAGTCAAAAATGGCTTGATTTTTGGAAACAATATAGAGGTATTCATATTTA
1041 AATGAGGGTTTACATTTGTTTTGTTTTGTAACCGTTAAAAAGAAGTTGTTTCCAGCTAATTATTGTGGTGTACTATATTT
1121 GTGAGCCTAGGGTAGGGGCACTGCTGCAACTTCTGCTTTCATCCCATGCCTCATCAATGAGGAAAGGGAACAAAGTGTAT
1201 AAAACTGCCACAATTGTATTTTAATTTTGAGGTATGATATTTTCAGATATTTCATAATTTCTAACCTCTGTTCTCTCAGT
1281 AAACAGAATGTCTGATCGATCATGCAGATACAATGTTGGTATTTGAGAGGTTAGTTTTTTTCCTACACTTTTTTTTGCCA
1361 ACTGACTTAACAACATTGCTGTCAGGTGGAAATTTCAAGCACTTTTGCACATTTAGTTCAGTGTTTGTTGAGAATCCATG
1441 GCTTAACCCACTTGTTTTGCTATTTTTTTCTTTGCTTTTAATTTTCCCCATCTGATTTTATCTCTGCGTTTCAGTGACCT
1521 ACCTTAAAACAACACACGAGAAGAGTTAAACTGGGTTCATTTTAATGATCAATTTACCTGCATATAAAATTTATTTTTAA
1601 TCAAGCTGATCTTAATGTATATAATCATTCTATTTGCTTTATTATCGGTGCAGGTAGGTCATTAACACCACTTCTTTTCA
1681 TCTGTACCACACCCTGGTGAAACCTTTGAAGACATAAAAAAAACCTGTCTGAGATGTTCTTTCTACCAATCTATATGTCT
1761 TTCGGTTATCAAGTGTTTCTGCATGGTAATGTCATGTAAATGCTGATATTGATTTCACTGGTCCATCTATATTTAAAACG
1841 TGCAAGAAAAAAATAAAATACTCTGCTCTAGCAAGTTTTGTGTAACAAAGGCATATCGTCATGTTAATAAATTTAAAACA
1921 TCATTCGTATAAAATATTTTAATTTTCTTGTATTTCATTTAGACCCAAGAACATGCTGACCAATGTGTTCTATATGTAAA
2001 CTACAAATTCTATGGTAGCTTTGTTGTATATTATTGTAAAATTATTTTAATAAGTCATGGGGATGACAATTTGATTATTA
2081 CAATTTAGTTTTCAGTAATCAAAAAGATTTCTATGAATTCTAAAAAATATTTTTTTCTATGAAATTACTAGTGCCCAGCT
2161 GTAGAATCTACCTTAGGTAGATGATCCCTAGACATACGTTGGTTTTGAGGGCTATTCAGCCATTCCATTTTACTCTCTAT
2241 TTAAAGGCCGTGAGCAAGCTTGTCATGAGCAAATATGTCAAGGGAGTCAATTTCTGACCAATCAAGTACACTAAATTAGA
2321 ATATTTTTAAAGTATGTAACATTCCCAGTTTCAGCCACAATTTAGCCAAGAATAAGATAAAAACTTGAATAAGAAGTAAG
2401 TAGCATAAATCAGTATTTAACCTAAAATTACATATTTGAAACAGAAGATATTATGTTATGCTCAGTAAATAATTAAGAGA
2481 TGGCATTGTGTAAGAAGGAGCCCTAGACTGAAAGTCAAGACATCTGAATTTCAGGCTGGAAAACTATCAGTATGATCTCA
2561 GCCTCAGTTCTCTTGTCTGTAAAATGGAAGAACTGGATTAGGCAGTTTGTAAGATTCCTCCTAACTTTCACAGTCGATGA
2641 CAAGATTGTCTTTTTATCTGATATTTTGAAGGGTATATTGCTTTGAAGTAAGTCTCAATAAGGCAATATATTTTAGGGCA
2721 TCTTTCTTCTTATCTCTGACAGTGTTCTTAAAATTATTTGAATATCATAAGAGCCTTGGTGTCTGTCCTAATTCCTTTCT
2801 CACTCACCGATGCTGAATACCCAGTTGAATCAAACTGTCAACCTACCAAAAACGATATTGTGGCTTATGGGTATTGCTGT
2881 CTCATTCTTGGTATATTCTTGTGTTAACTGCCCATTGGCCTGAAAATACTCATTGTAAGCCTGAAAAAAAAAATCTTTCC
2961 CACTGTTTTTTCTGCTTGTTGTAAGAATCAAATGAAATAATGTATGTGAAAGCACCTTGTAAACTGTAACCTATCAATGT
3041 AAAATGTTAAGGTGTGTTGTTATTTCATTAATTACTTCTTTGTTTAGAATGGAATTTCCTATGCACTACTGTAGCTAGGA
3121 AATGCTGAAAACAACTGTGTTTTTTAATTAATCAATAACTGCAAAATTAAAGTACCTTCAATGGATAAGACAAAAAAAAA
3201 AAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' ucgccgGUCGGGACGACAGUCg 5'
                || | :||||||||| 
Target 5' acttaaCAACATTGCTGTCAGg 3'
 1365 - 1386 160.00 -16.90
2 
miRNA  3' ucgccggUCGGGACGACAGUCg 5'
                 ||: :|||| |||| 
Target 5' aaggataAGTGTTGCTTTCAGt 3'
 372 - 393 127.00 -17.10
3 
miRNA  3' ucgccGGUCGG-GAC--GACAGUCg 5'
               |:| || |||  || |||| 
Target 5' aatttCTAACCTCTGTTCTCTCAGt 3'
 1256 - 1280 123.00 -11.80
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN8638801 3 COSMIC
COSN30171857 6 COSMIC
COSN30158795 25 COSMIC
COSN31503637 48 COSMIC
COSN32053871 64 COSMIC
COSN1109248 69 COSMIC
COSN30512947 71 COSMIC
COSN30152670 84 COSMIC
COSN13563050 113 COSMIC
COSN30710108 117 COSMIC
COSN30145968 118 COSMIC
COSN30500267 123 COSMIC
COSN28858379 135 COSMIC
COSN31589689 150 COSMIC
COSN28890661 166 COSMIC
COSN15679982 226 COSMIC
COSN31607448 273 COSMIC
COSN8638802 285 COSMIC
COSN20090269 377 COSMIC
COSN31515369 458 COSMIC
COSN30109954 485 COSMIC
COSN31582926 623 COSMIC
COSN1461023 767 COSMIC
COSN31546382 813 COSMIC
COSN31489524 882 COSMIC
COSN25166405 1063 COSMIC
COSN31522781 1144 COSMIC
COSN31595598 1165 COSMIC
COSN31595152 1187 COSMIC
COSN31584901 1298 COSMIC
COSN31556708 1299 COSMIC
COSN30164571 1328 COSMIC
COSN31519418 1366 COSMIC
COSN31544473 1418 COSMIC
COSN6471072 1487 COSMIC
COSN30542187 1494 COSMIC
COSN31607839 1614 COSMIC
COSN193624 1734 COSMIC
COSN193625 1735 COSMIC
COSN28292703 1760 COSMIC
COSN10055045 1803 COSMIC
COSN31488307 1806 COSMIC
COSN24037783 1812 COSMIC
COSN31522770 1919 COSMIC
COSN31520540 1947 COSMIC
COSN31584691 1948 COSMIC
COSN8511889 1967 COSMIC
COSN31520796 1991 COSMIC
COSN31482991 2011 COSMIC
COSN31532701 2013 COSMIC
COSN31609278 2026 COSMIC
COSN31528510 2057 COSMIC
COSN31515165 2107 COSMIC
COSN8511890 2776 COSMIC
COSN5169990 2832 COSMIC
COSN19552239 2859 COSMIC
COSN31486548 2902 COSMIC
COSN8145851 2915 COSMIC
COSN29515201 2954 COSMIC
COSN31585737 2954 COSMIC
COSN31607270 2956 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1460716808 4 dbSNP
rs201502546 9 dbSNP
rs1223707258 12 dbSNP
rs1322367624 13 dbSNP
rs372591216 15 dbSNP
rs751130772 19 dbSNP
rs759526728 23 dbSNP
rs1316960018 29 dbSNP
rs764146524 30 dbSNP
rs1337968233 32 dbSNP
rs751434962 34 dbSNP
rs757079312 35 dbSNP
rs890130665 41 dbSNP
rs1330059845 43 dbSNP
rs532543813 45 dbSNP
rs1391332185 57 dbSNP
rs1007689780 58 dbSNP
rs1470367101 60 dbSNP
rs1405594102 61 dbSNP
rs1017358697 63 dbSNP
rs898951236 67 dbSNP
rs1350764269 72 dbSNP
rs1364179682 73 dbSNP
rs1225233203 74 dbSNP
rs754434068 75 dbSNP
rs1258231808 79 dbSNP
rs1311526670 81 dbSNP
rs1000629715 88 dbSNP
rs1460530376 88 dbSNP
rs1260856183 93 dbSNP
rs1210212867 96 dbSNP
rs1026596065 101 dbSNP
rs1353212368 103 dbSNP
rs1054460894 109 dbSNP
rs1238908695 110 dbSNP
rs950596113 112 dbSNP
rs781174593 113 dbSNP
rs1019116693 120 dbSNP
rs552754264 124 dbSNP
rs996272512 125 dbSNP
rs776407513 130 dbSNP
rs1313931318 140 dbSNP
rs865849992 143 dbSNP
rs1252774075 144 dbSNP
rs960030808 145 dbSNP
rs991937789 150 dbSNP
rs574076031 151 dbSNP
rs1240737145 153 dbSNP
rs1014600020 155 dbSNP
rs1447251518 162 dbSNP
rs1424991516 165 dbSNP
rs531802093 168 dbSNP
rs1349056332 169 dbSNP
rs1294502134 172 dbSNP
rs961975003 182 dbSNP
rs947485399 183 dbSNP
rs548510892 186 dbSNP
rs148489326 190 dbSNP
rs1427221933 194 dbSNP
rs978932965 210 dbSNP
rs1306921874 214 dbSNP
rs11552591 223 dbSNP
rs1327228550 233 dbSNP
rs1354735103 234 dbSNP
rs561017694 241 dbSNP
rs145309062 243 dbSNP
rs917809179 248 dbSNP
rs1367210754 253 dbSNP
rs1444007606 255 dbSNP
rs924797874 263 dbSNP
rs600674 264 dbSNP
rs1169109678 265 dbSNP
rs1366571062 268 dbSNP
rs1475483570 269 dbSNP
rs927402262 277 dbSNP
rs936093902 278 dbSNP
rs1340018877 283 dbSNP
rs41301190 284 dbSNP
rs147184083 285 dbSNP
rs546549480 289 dbSNP
rs1359314465 291 dbSNP
rs539043967 294 dbSNP
rs1216394439 301 dbSNP
rs1040618451 303 dbSNP
rs766601722 319 dbSNP
rs1439775516 332 dbSNP
rs1225531408 345 dbSNP
rs555691182 357 dbSNP
rs1039146195 358 dbSNP
rs1303566131 365 dbSNP
rs1404149735 367 dbSNP
rs1363613095 374 dbSNP
rs369858724 375 dbSNP
rs575741094 377 dbSNP
rs1418183558 383 dbSNP
rs996338502 392 dbSNP
rs1481232150 400 dbSNP
rs1200576104 406 dbSNP
rs995020483 406 dbSNP
rs1488984427 408 dbSNP
rs777570175 415 dbSNP
rs1026128449 417 dbSNP
rs887908811 422 dbSNP
rs41301192 427 dbSNP
rs1388825781 433 dbSNP
rs1015062325 435 dbSNP
rs1449449075 451 dbSNP
rs1284222064 454 dbSNP
rs768124966 457 dbSNP
rs616790 462 dbSNP
rs991809496 473 dbSNP
rs1442865321 477 dbSNP
rs1353374943 486 dbSNP
rs1034932485 503 dbSNP
rs1326246165 509 dbSNP
rs959584544 515 dbSNP
rs1411165894 524 dbSNP
rs1470699541 530 dbSNP
rs1406345106 532 dbSNP
rs1175354277 538 dbSNP
rs1480278490 542 dbSNP
rs991492271 547 dbSNP
rs1423517212 564 dbSNP
rs572190612 568 dbSNP
rs1470815159 574 dbSNP
rs968807285 588 dbSNP
rs763512192 590 dbSNP
rs979266155 595 dbSNP
rs1232848407 596 dbSNP
rs924746869 598 dbSNP
rs1462757094 601 dbSNP
rs956212259 606 dbSNP
rs980637060 608 dbSNP
rs181252049 612 dbSNP
rs912140269 615 dbSNP
rs1310169834 616 dbSNP
rs1286125687 618 dbSNP
rs771229157 626 dbSNP
rs1224170214 633 dbSNP
rs755980472 638 dbSNP
rs879458438 640 dbSNP
rs564371968 643 dbSNP
rs1382897510 644 dbSNP
rs1047514793 650 dbSNP
rs111670440 655 dbSNP
rs746025056 659 dbSNP
rs1401697849 660 dbSNP
rs1056339895 667 dbSNP
rs1215922118 670 dbSNP
rs932243799 671 dbSNP
rs144259212 673 dbSNP
rs753872826 678 dbSNP
rs1006770729 685 dbSNP
rs1482382144 702 dbSNP
rs1244355953 703 dbSNP
rs1036141005 710 dbSNP
rs1316195272 712 dbSNP
rs1283721450 713 dbSNP
rs897550350 721 dbSNP
rs1022934630 722 dbSNP
rs1359468561 725 dbSNP
rs1160991050 734 dbSNP
rs576057119 745 dbSNP
rs151182362 749 dbSNP
rs1313773215 753 dbSNP
rs1000200159 754 dbSNP
rs544098010 756 dbSNP
rs1031716207 758 dbSNP
rs1412590224 759 dbSNP
rs969010382 763 dbSNP
rs1002126185 769 dbSNP
rs915137839 770 dbSNP
rs1032652862 777 dbSNP
rs868573371 788 dbSNP
rs1162983411 799 dbSNP
rs185551158 803 dbSNP
rs956160128 805 dbSNP
rs1264115354 815 dbSNP
rs988367377 816 dbSNP
rs200089197 818 dbSNP
rs913341114 823 dbSNP
rs967426258 825 dbSNP
rs548639457 829 dbSNP
rs188700583 837 dbSNP
rs1386099250 840 dbSNP
rs1434111001 860 dbSNP
rs1318838280 867 dbSNP
rs912070905 873 dbSNP
rs778570616 877 dbSNP
rs11552592 883 dbSNP
rs1241969379 889 dbSNP
rs1308819103 890 dbSNP
rs945092446 893 dbSNP
rs931959463 894 dbSNP
rs527877064 895 dbSNP
rs1295764231 907 dbSNP
rs1335717212 910 dbSNP
rs180770222 914 dbSNP
rs570811520 916 dbSNP
rs1266484145 921 dbSNP
rs920240570 922 dbSNP
rs539702047 924 dbSNP
rs1456395004 926 dbSNP
rs34428513 927 dbSNP
rs909439005 932 dbSNP
rs140086419 936 dbSNP
rs1428179911 937 dbSNP
rs1421814309 938 dbSNP
rs1036934018 942 dbSNP
rs569289313 943 dbSNP
rs1047463121 964 dbSNP
rs907611447 970 dbSNP
rs1268093981 978 dbSNP
rs939105819 982 dbSNP
rs1251406791 983 dbSNP
rs1203257146 984 dbSNP
rs1056284840 988 dbSNP
rs894982457 989 dbSNP
rs1284867113 995 dbSNP
rs1315658359 995 dbSNP
rs1225727570 1000 dbSNP
rs1346542509 1005 dbSNP
rs1236456796 1007 dbSNP
rs1385611164 1010 dbSNP
rs1475252517 1016 dbSNP
rs1012130319 1020 dbSNP
rs1189553832 1021 dbSNP
rs1013351442 1023 dbSNP
rs535232398 1026 dbSNP
rs1046142769 1029 dbSNP
rs778909729 1031 dbSNP
rs186137437 1035 dbSNP
rs903809893 1036 dbSNP
rs1398364515 1038 dbSNP
rs572197127 1039 dbSNP
rs534822439 1042 dbSNP
rs1480603177 1043 dbSNP
rs1032289636 1046 dbSNP
rs149885023 1049 dbSNP
rs1031663882 1053 dbSNP
rs1009443390 1055 dbSNP
rs1251216471 1072 dbSNP
rs1176108245 1073 dbSNP
rs1412751467 1074 dbSNP
rs546499624 1075 dbSNP
rs1203914908 1077 dbSNP
rs1356103060 1098 dbSNP
rs1324650171 1104 dbSNP
rs965143686 1111 dbSNP
rs956107870 1116 dbSNP
rs191904497 1122 dbSNP
rs1308411450 1130 dbSNP
rs1446127501 1131 dbSNP
rs1374773341 1132 dbSNP
rs1338881380 1137 dbSNP
rs1286638667 1139 dbSNP
rs1019084117 1144 dbSNP
rs923329420 1160 dbSNP
rs953406353 1162 dbSNP
rs965254831 1167 dbSNP
rs974977148 1171 dbSNP
rs1240179545 1174 dbSNP
rs1281698243 1179 dbSNP
rs909503739 1188 dbSNP
rs1343488586 1191 dbSNP
rs1244465137 1195 dbSNP
rs1183776472 1197 dbSNP
rs766113312 1199 dbSNP
rs751169865 1201 dbSNP
rs1199083769 1206 dbSNP
rs1028312827 1217 dbSNP
rs949508980 1227 dbSNP
rs1240080806 1230 dbSNP
rs1281684157 1244 dbSNP
rs1351537970 1247 dbSNP
rs1046193353 1248 dbSNP
rs1485685847 1249 dbSNP
rs1212442805 1250 dbSNP
rs1249127938 1255 dbSNP
rs952303175 1262 dbSNP
rs1472090443 1264 dbSNP
rs759122931 1270 dbSNP
rs1385417062 1271 dbSNP
rs1365255063 1274 dbSNP
rs1476924344 1287 dbSNP
rs1157921021 1288 dbSNP
rs1417816781 1289 dbSNP
rs1387050579 1298 dbSNP
rs983096726 1299 dbSNP
rs1366351145 1304 dbSNP
rs1171877853 1305 dbSNP
rs144903009 1307 dbSNP
rs1436625292 1309 dbSNP
rs41301194 1312 dbSNP
rs145166827 1314 dbSNP
rs893437271 1320 dbSNP
rs916375894 1328 dbSNP
rs184157822 1330 dbSNP
rs1294658814 1331 dbSNP
rs1043602055 1336 dbSNP
rs1355733699 1341 dbSNP
rs1329656026 1348 dbSNP
rs1020844174 1349 dbSNP
rs1297317650 1349 dbSNP
rs903758103 1350 dbSNP
rs935276126 1358 dbSNP
rs1350734808 1382 dbSNP
rs1367358479 1396 dbSNP
rs1235826458 1404 dbSNP
rs528980989 1412 dbSNP
rs571336316 1417 dbSNP
rs1053026482 1423 dbSNP
rs891811317 1425 dbSNP
rs1008904745 1449 dbSNP
rs1480026238 1455 dbSNP
rs1195957679 1456 dbSNP
rs371253249 1457 dbSNP
rs1387969748 1463 dbSNP
rs1169237567 1467 dbSNP
rs1030396321 1469 dbSNP
rs1252254784 1471 dbSNP
rs562208668 1475 dbSNP
rs1197951493 1476 dbSNP
rs1193377339 1481 dbSNP
rs7528226 1483 dbSNP
rs17131308 1487 dbSNP
rs1222964390 1490 dbSNP
rs1027846364 1491 dbSNP
rs186740577 1503 dbSNP
rs756081085 1505 dbSNP
rs983715234 1508 dbSNP
rs777544301 1509 dbSNP
rs1277874117 1515 dbSNP
rs550801000 1518 dbSNP
rs1389562891 1520 dbSNP
rs1283787068 1524 dbSNP
rs1014561880 1527 dbSNP
rs960361602 1530 dbSNP
rs1347574226 1531 dbSNP
rs41301196 1538 dbSNP
rs1300066442 1539 dbSNP
rs138917925 1553 dbSNP
rs775844631 1556 dbSNP
rs979659709 1570 dbSNP
rs772370368 1573 dbSNP
rs935221371 1579 dbSNP
rs1052312384 1580 dbSNP
rs1053499568 1581 dbSNP
rs893479108 1607 dbSNP
rs539655245 1611 dbSNP
rs945029918 1616 dbSNP
rs944708046 1618 dbSNP
rs1257596165 1622 dbSNP
rs1040403189 1624 dbSNP
rs1197002271 1635 dbSNP
rs900565802 1646 dbSNP
rs996293749 1647 dbSNP
rs192041352 1648 dbSNP
rs1353878217 1649 dbSNP
rs887950270 1651 dbSNP
rs1365379769 1657 dbSNP
rs1281278805 1658 dbSNP
rs1375532456 1685 dbSNP
rs568865971 1688 dbSNP
rs1454272320 1689 dbSNP
rs41301198 1697 dbSNP
rs960983575 1704 dbSNP
rs1469653820 1706 dbSNP
rs112374386 1708 dbSNP
rs1414312671 1715 dbSNP
rs1008061044 1716 dbSNP
rs1013658229 1716 dbSNP
rs1016328089 1716 dbSNP
rs534388713 1717 dbSNP
rs1176960649 1724 dbSNP
rs963722361 1724 dbSNP
rs1260985500 1726 dbSNP
rs972077631 1729 dbSNP
rs1172677557 1732 dbSNP
rs1023325866 1747 dbSNP
rs969522900 1750 dbSNP
rs558002501 1754 dbSNP
rs979219060 1755 dbSNP
rs1286190049 1759 dbSNP
rs1166102399 1765 dbSNP
rs1352282551 1780 dbSNP
rs1306412921 1797 dbSNP
rs776990849 1799 dbSNP
rs1397061610 1801 dbSNP
rs925083855 1806 dbSNP
rs956541962 1810 dbSNP
rs1301960635 1813 dbSNP
rs1447678740 1819 dbSNP
rs1320797199 1830 dbSNP
rs1420872517 1837 dbSNP
rs41301200 1840 dbSNP
rs1156909525 1841 dbSNP
rs1446582466 1844 dbSNP
rs1414795616 1847 dbSNP
rs1181510518 1850 dbSNP
rs1385689200 1853 dbSNP
rs1363317014 1859 dbSNP
rs1382273628 1861 dbSNP
rs11552593 1863 dbSNP
rs1482124389 1865 dbSNP
rs1243662294 1869 dbSNP
rs1297171127 1876 dbSNP
rs938167558 1881 dbSNP
rs1232229534 1893 dbSNP
rs912465834 1894 dbSNP
rs1273440173 1898 dbSNP
rs537375077 1899 dbSNP
rs943991723 1902 dbSNP
rs1226281720 1910 dbSNP
rs1377383139 1911 dbSNP
rs41301202 1924 dbSNP
rs921968917 1928 dbSNP
rs537878145 1943 dbSNP
rs1360435445 1950 dbSNP
rs922556200 1951 dbSNP
rs1254254280 1952 dbSNP
rs41301204 1958 dbSNP
rs1188857656 1967 dbSNP
rs1420329481 1969 dbSNP
rs1422253418 1972 dbSNP
rs887899464 1982 dbSNP
rs11552594 1988 dbSNP
rs1158898227 2003 dbSNP
rs555433476 2011 dbSNP
rs1036563480 2018 dbSNP
rs115681692 2019 dbSNP
rs1488494863 2043 dbSNP
rs1013858035 2050 dbSNP
rs1005357040 2053 dbSNP
rs1455866092 2058 dbSNP
rs1218797452 2062 dbSNP
rs1301611791 2067 dbSNP
rs1399365451 2068 dbSNP
rs1308871884 2082 dbSNP
rs1258371000 2083 dbSNP
rs1023695318 2084 dbSNP
rs1219631878 2089 dbSNP
rs768652258 2094 dbSNP
rs969089930 2109 dbSNP
rs1276802195 2111 dbSNP
rs377644515 2113 dbSNP
rs899231875 2114 dbSNP
rs1293487032 2127 dbSNP
rs1292989427 2128 dbSNP
rs1456503061 2129 dbSNP
rs1356486855 2130 dbSNP
rs1032051002 2131 dbSNP
rs564374369 2133 dbSNP
rs370944275 2135 dbSNP
rs1357021063 2140 dbSNP
rs993947559 2142 dbSNP
rs956490015 2151 dbSNP
rs773568951 2158 dbSNP
rs970683959 2176 dbSNP
rs987915104 2179 dbSNP
rs1433674327 2180 dbSNP
rs1266648450 2183 dbSNP
rs912413633 2198 dbSNP
rs571852580 2199 dbSNP
rs1258231084 2202 dbSNP
rs1197648106 2204 dbSNP
rs1317634655 2211 dbSNP
rs1256526704 2212 dbSNP
rs959833532 2218 dbSNP
rs1313279761 2222 dbSNP
rs148172520 2237 dbSNP
rs1211731654 2240 dbSNP
rs1332243171 2242 dbSNP
rs1259843795 2247 dbSNP
rs1471765577 2250 dbSNP
rs1176982380 2251 dbSNP
rs1466411498 2252 dbSNP
rs915014669 2253 dbSNP
rs1173878374 2263 dbSNP
rs1420294599 2266 dbSNP
rs1238288539 2271 dbSNP
rs761933264 2277 dbSNP
rs1456155477 2282 dbSNP
rs1244652518 2286 dbSNP
rs975362301 2306 dbSNP
rs1202534882 2307 dbSNP
rs966478461 2330 dbSNP
rs1231739022 2338 dbSNP
rs1310043922 2361 dbSNP
rs1355899466 2361 dbSNP
rs533341480 2366 dbSNP
rs922273422 2368 dbSNP
rs543753117 2372 dbSNP
rs1401252000 2380 dbSNP
rs1300967602 2382 dbSNP
rs1375340127 2385 dbSNP
rs931997579 2388 dbSNP
rs1380894006 2390 dbSNP
rs41301206 2394 dbSNP
rs1312898898 2398 dbSNP
rs1437348378 2404 dbSNP
rs374010719 2405 dbSNP
rs911128540 2410 dbSNP
rs909284723 2415 dbSNP
rs1255943142 2416 dbSNP
rs1038206392 2422 dbSNP
rs899282912 2424 dbSNP
rs1287439953 2430 dbSNP
rs1215982137 2433 dbSNP
rs993591557 2444 dbSNP
rs1407539727 2445 dbSNP
rs1286118405 2450 dbSNP
rs759210843 2452 dbSNP
rs1297243313 2456 dbSNP
rs1373853042 2460 dbSNP
rs1310281838 2464 dbSNP
rs1401675719 2477 dbSNP
rs1225232888 2487 dbSNP
rs767120230 2494 dbSNP
rs1417253929 2497 dbSNP
rs1392282638 2501 dbSNP
rs1163440680 2507 dbSNP
rs34554723 2507 dbSNP
rs896667189 2525 dbSNP
rs529522319 2528 dbSNP
rs41301208 2529 dbSNP
rs1366407278 2556 dbSNP
rs1003530475 2595 dbSNP
rs1038726333 2596 dbSNP
rs182915082 2600 dbSNP
rs905483114 2602 dbSNP
rs1264445483 2612 dbSNP
rs528220261 2613 dbSNP
rs1193592821 2616 dbSNP
rs1011525566 2630 dbSNP
rs1292073657 2636 dbSNP
rs1022468240 2637 dbSNP
rs1355893296 2638 dbSNP
rs1263968694 2639 dbSNP
rs1482113375 2645 dbSNP
rs967239400 2646 dbSNP
rs1233646134 2647 dbSNP
rs1000530120 2649 dbSNP
rs141828897 2658 dbSNP
rs1395032026 2661 dbSNP
rs34882982 2668 dbSNP
rs1323623968 2673 dbSNP
rs892191337 2674 dbSNP
rs1404309612 2675 dbSNP
rs186836627 2678 dbSNP
rs1172379204 2684 dbSNP
rs1467458662 2686 dbSNP
rs1019371726 2698 dbSNP
rs1424815724 2699 dbSNP
rs41301210 2701 dbSNP
rs985073397 2707 dbSNP
rs975689822 2709 dbSNP
rs1474699295 2710 dbSNP
rs1249025371 2713 dbSNP
rs1199667047 2717 dbSNP
rs1028232041 2718 dbSNP
rs1451115105 2719 dbSNP
rs952765152 2723 dbSNP
rs1251305947 2724 dbSNP
rs1407697645 2734 dbSNP
rs911170791 2735 dbSNP
rs1257160547 2738 dbSNP
rs1169362098 2742 dbSNP
rs1216626467 2750 dbSNP
rs1347023977 2764 dbSNP
rs1435044306 2765 dbSNP
rs984773056 2768 dbSNP
rs1328863189 2773 dbSNP
rs909232456 2774 dbSNP
rs1447104660 2779 dbSNP
rs940729096 2780 dbSNP
rs1170391425 2782 dbSNP
rs1323582366 2788 dbSNP
rs41301212 2797 dbSNP
rs1427787545 2804 dbSNP
rs1173682712 2808 dbSNP
rs918040084 2809 dbSNP
rs554089542 2810 dbSNP
rs1180628357 2819 dbSNP
rs1458368006 2822 dbSNP
rs1202182031 2825 dbSNP
rs1047869693 2842 dbSNP
rs1279169763 2843 dbSNP
rs1218600980 2850 dbSNP
rs1342211553 2854 dbSNP
rs557144876 2855 dbSNP
rs905431655 2858 dbSNP
rs1328877583 2859 dbSNP
rs1440398140 2864 dbSNP
rs939370695 2870 dbSNP
rs1214029382 2871 dbSNP
rs936942433 2877 dbSNP
rs1055124820 2882 dbSNP
rs567559080 2890 dbSNP
rs1053354377 2897 dbSNP
rs150607894 2903 dbSNP
rs760159265 2910 dbSNP
rs1252689472 2912 dbSNP
rs1011159056 2915 dbSNP
rs555753348 2919 dbSNP
rs796884226 2927 dbSNP
rs1400917252 2933 dbSNP
rs1019356036 2934 dbSNP
rs1469183026 2936 dbSNP
rs1196113971 2939 dbSNP
rs900950229 2940 dbSNP
rs1022944350 2944 dbSNP
rs1175715045 2944 dbSNP
rs902703615 2944 dbSNP
rs1209214072 2951 dbSNP
rs1484641291 2962 dbSNP
rs1051529 2963 dbSNP
rs1246700216 2964 dbSNP
rs1474161031 2968 dbSNP
rs879332990 2969 dbSNP
rs1419810481 2974 dbSNP
rs996677186 2982 dbSNP
rs572333888 2985 dbSNP
rs745687591 2989 dbSNP
rs1216615078 2996 dbSNP
rs1352350363 3003 dbSNP
rs541167581 3006 dbSNP
rs1229704616 3008 dbSNP
rs1051544 3015 dbSNP
rs1029390891 3016 dbSNP
rs369254234 3017 dbSNP
rs565485368 3017 dbSNP
rs369459567 3023 dbSNP
rs557828879 3025 dbSNP
rs985566079 3032 dbSNP
rs984053579 3037 dbSNP
rs962654302 3041 dbSNP
rs1016241277 3045 dbSNP
rs962041679 3047 dbSNP
rs766211674 3053 dbSNP
rs929816502 3064 dbSNP
rs577671491 3074 dbSNP
rs918002124 3079 dbSNP
rs949530027 3080 dbSNP
rs1181063731 3081 dbSNP
rs981268119 3083 dbSNP
rs1265172793 3084 dbSNP
rs928067688 3107 dbSNP
rs13376116 3110 dbSNP
rs1055579376 3112 dbSNP
rs895166369 3113 dbSNP
rs1321937310 3133 dbSNP
rs556807537 3134 dbSNP
rs946679661 3135 dbSNP
rs1232986017 3136 dbSNP
rs1353970952 3139 dbSNP
rs1280600384 3141 dbSNP
rs1272764426 3150 dbSNP
rs1401182734 3161 dbSNP
rs190169204 3163 dbSNP
rs936890662 3177 dbSNP
rs1215904344 3182 dbSNP
rs573933050 3184 dbSNP
rs1044011964 3185 dbSNP
rs902755730 3186 dbSNP
rs999688529 3192 dbSNP
rs1164358055 3193 dbSNP
rs1350614472 3193 dbSNP
rs1459629122 3194 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Disease 5567.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM714644. RNA binding protein: AGO2. Condition:completeT1 ...

- Kishore S; Jaskiewicz L; Burger L; Hausser et al., 2011, Nature methods.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' ucgccggucgggacgacAGUCg 5'
                           |||| 
Target 5' -----------------UCAGg 3'
 		1 - 5
Article - Kishore S; Jaskiewicz L; Burger L; Hausser et al.
- Nature methods, 2011
Cross-linking and immunoprecipitation (CLIP) is increasingly used to map transcriptome-wide binding sites of RNA-binding proteins. We developed a method for CLIP data analysis, and applied it to compare CLIP with photoactivatable ribonucleoside-enhanced CLIP (PAR-CLIP) and to uncover how differences in cross-linking and ribonuclease digestion affect the identified sites. We found only small differences in accuracies of these methods in identifying binding sites of HuR, which binds low-complexity sequences, and Argonaute 2, which has a complex binding specificity. We found that cross-link-induced mutations led to single-nucleotide resolution for both PAR-CLIP and CLIP. Our results confirm the expectation from original CLIP publications that RNA-binding proteins do not protect their binding sites sufficiently under the denaturing conditions used during the CLIP procedure, and we show that extensive digestion with sequence-specific RNases strongly biases the recovered binding sites. This bias can be substantially reduced by milder nuclease digestion conditions.
LinkOut: [PMID: 21572407]
CLIP-seq Support 1 for dataset GSM4903833
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_a
Location of target site NM_001242857 | 3UTR | AGGUGGAAAUUUCAAGCACUUUUGCACAUUUAGUUCAGUGUUUGUUGAGAAUCCAUGGCUUAACCCACUUGUUUUGCUAUUUUUUUCUUUGCUUUUAAUUUUCCCCAUCUGAUUUUAUCUCUGC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM714644
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / completeT1, repA
Location of target site ENST00000370689.2 | 3UTR | UCAGGUGGAAAUUUCAAGCACUUUUGCACAUUUAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 21572407 / GSE28865
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
60 hsa-miR-4526 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT080216 PRKACB protein kinase cAMP-activated catalytic subunit beta 2 2
MIRT100350 DDX39B DExD-box helicase 39B 2 2
MIRT445480 KDM6A lysine demethylase 6A 2 2
MIRT450233 ZNF25 zinc finger protein 25 2 2
MIRT465783 TMOD3 tropomodulin 3 2 8
MIRT466253 TMBIM6 transmembrane BAX inhibitor motif containing 6 2 2
MIRT470395 PPP1R16B protein phosphatase 1 regulatory subunit 16B 2 2
MIRT470442 PPP1R15B protein phosphatase 1 regulatory subunit 15B 2 8
MIRT476323 GLTSCR1L BRD4 interacting chromatin remodeling complex associated protein like 2 2
MIRT479706 CCNT1 cyclin T1 2 2
MIRT481925 ANKRD33B ankyrin repeat domain 33B 2 2
MIRT484016 ZNF776 zinc finger protein 776 2 4
MIRT497022 INO80B INO80 complex subunit B 2 2
MIRT502526 EPHA2 EPH receptor A2 2 4
MIRT513497 SSR1 signal sequence receptor subunit 1 2 6
MIRT517846 RPS4X ribosomal protein S4, X-linked 2 4
MIRT533734 TMEM200C transmembrane protein 200C 2 2
MIRT535904 MKNK2 MAP kinase interacting serine/threonine kinase 2 2 2
MIRT537537 EZR ezrin 2 2
MIRT538756 CACUL1 CDK2 associated cullin domain 1 2 2
MIRT540307 GFPT1 glutamine--fructose-6-phosphate transaminase 1 2 2
MIRT545510 EPT1 selenoprotein I 2 2
MIRT548829 CHIC1 cysteine rich hydrophobic domain 1 2 2
MIRT569600 TRIM29 tripartite motif containing 29 2 2
MIRT572462 ZNF516 zinc finger protein 516 2 2
MIRT575457 Ints2 integrator complex subunit 2 2 3
MIRT609411 SLC25A45 solute carrier family 25 member 45 2 2
MIRT609622 TRPC4AP transient receptor potential cation channel subfamily C member 4 associated protein 2 2
MIRT609666 INTS2 integrator complex subunit 2 2 3
MIRT609994 PIGS phosphatidylinositol glycan anchor biosynthesis class S 2 2
MIRT611691 NODAL nodal growth differentiation factor 2 2
MIRT615720 BACE2 beta-site APP-cleaving enzyme 2 2 2
MIRT616383 C1orf87 chromosome 1 open reading frame 87 2 2
MIRT616593 KLHL9 kelch like family member 9 2 2
MIRT628162 HIP1 huntingtin interacting protein 1 2 2
MIRT628376 CAMK2N1 calcium/calmodulin dependent protein kinase II inhibitor 1 2 2
MIRT629203 PAPOLA poly(A) polymerase alpha 2 2
MIRT635006 ADPRH ADP-ribosylarginine hydrolase 2 2
MIRT645493 TRIM63 tripartite motif containing 63 2 2
MIRT646750 MUC4 mucin 4, cell surface associated 2 2
MIRT649613 ITPKC inositol-trisphosphate 3-kinase C 2 2
MIRT656228 MFSD6 major facilitator superfamily domain containing 6 2 2
MIRT658196 FBXO44 F-box protein 44 2 2
MIRT661757 MICA MHC class I polypeptide-related sequence A 2 2
MIRT662866 UPF3A UPF3A, regulator of nonsense mediated mRNA decay 2 2
MIRT666738 RALY RALY heterogeneous nuclear ribonucleoprotein 2 2
MIRT690391 PARP15 poly(ADP-ribose) polymerase family member 15 2 2
MIRT699795 SEC24A SEC24 homolog A, COPII coat complex component 2 2
MIRT700033 RPL22 ribosomal protein L22 2 2
MIRT701741 MTDH metadherin 2 2
MIRT702330 KMT2A lysine methyltransferase 2A 2 2
MIRT702672 IRS2 insulin receptor substrate 2 2 2
MIRT708730 LSAMP limbic system-associated membrane protein 2 2
MIRT709230 GPSM2 G protein signaling modulator 2 2 2
MIRT717503 UFL1 UFM1 specific ligase 1 2 2
MIRT718533 PIGQ phosphatidylinositol glycan anchor biosynthesis class Q 2 2
MIRT719845 MON1B MON1 homolog B, secretory trafficking associated 2 2
MIRT720957 TMEM151B transmembrane protein 151B 2 2
MIRT724816 MSX2 msh homeobox 2 2 2
MIRT725369 MTF2 metal response element binding transcription factor 2 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-4 Dexamethasone approved 5743 Microarray primary rat thymocytes 20847043 2010 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-4526 Cisplatin 5460033 NSC119875 approved resistant cell line (BxPC3)
hsa-miR-4526 Gefitinib 123631 NSC715055 approved resistant cell line (PC9)
hsa-miR-4526 Osimertinib 71496458 NSC779217 approved resistant cell line (PC9)
hsa-miR-4526 Platinum 23939 resistant tissue (non-small cell lung cancer)
hsa-miR-4526 Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (100 ng/ml)

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