miRTarBase - #MIRT080581


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pre-miRNA Information
pre-miRNA hsa-mir-488   
Genomic Coordinates chr1: 177029363 - 177029445
Synonyms MIRN488, hsa-mir-488, MIR488
Description Homo sapiens miR-488 stem-loop
Comment miR-488-3p cloned in has a 1 nt 3' extension (U), which is incompatible with the genome sequence.
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-488-5p
Sequence 14| CCCAGAUAAUGGCACUCUCAA |34
Evidence Experimental
Experiments Array-cloned
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 14 1 - 177029419 29233923 MiREDiBase
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSN216801 2 COSMIC
COSN30173753 3 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1333804746 2 dbSNP
rs186200318 4 dbSNP
rs199722070 5 dbSNP
rs1306874660 6 dbSNP
rs1460081115 7 dbSNP
rs756247271 10 dbSNP
rs1176767140 11 dbSNP
rs902346881 12 dbSNP
rs1426977290 13 dbSNP
rs750676501 14 dbSNP
rs181176070 21 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol PMAIP1   
Synonyms APR, NOXA
Description phorbol-12-myristate-13-acetate-induced protein 1
Transcript NM_021127   
Expression
Putative miRNA Targets on PMAIP1
3'UTR of PMAIP1
(miRNA target sites are highlighted)		 
>PMAIP1|NM_021127|3'UTR
   1 CTGCATCAAAAACTTGCATGAGGGGACTCCTTCAAAAGAGTTTTCTCAGGAGGTGCACGTTTCATCAATTTGAAGAAAGA
  81 CTGCATTGTAATTGAGAGGAATGTGAAGGTGCATTCATGGGTGCCCTTGGAAACGGAAGATGGAATACATCAAAGTGAAT
 161 TTCTGTTCAAGTTTTCCCAGATTATCATTCTTTGGGATGAGAGAACATTATAAAACCACTTTGTTTATTTTAAAGCAAGA
 241 ATGGAAGACCCTTGAAAATAAAGAAGTAATTATTGACACATTTCTTTTTTACTTAGAGAATCGTTCTAGTGTTTTTGCCG
 321 AAGATTACCGCTGGCCTACTGTGAAGGGAGATGACCTGTGATTAGACTGGGCGGCTGGGGAGAAACAGTTCAGTGCATTG
 401 TTGTTGTTGCTGTTTTTGGTGTTTTGCTTTTCAGTGCCAACTCAGCACATTGTATATGATTCGGTTTATACATATTACCT
 481 TGTTATAATGAAAAAACTCATTCTGAGAACACTGAAATGTTATACTCAGTGTTGATTTCTTCGGTCACTACACAACGTAA
 561 AATCATTTGTTTCTTTTGACTCAAATTGTATTGCTTCTGTTCAGATGATCTTTCATTCAATGTGTTCCTGTTGGGCGTTA
 641 CTAGAAACTATGGAAAACTGGAAAATAACTTTGAAAAAATTGGATAAAGTATAGGAGGGTTACTTGGGGCCAGTAAATCA
 721 GTAGACTGAACATTCAATATAATAAAAGAACATGGGGATTTTGTATAACCAGGGATAATAAAAAGAAAAAAGAAGTTAAT
 801 TTTTAATTGATGTTTTTGAAACTTAGTAGAACAAATATTCAGAAGTAACTTGATAAGATATGAATGTTTCTAAAGAAGTT
 881 TCTAAAGGTTCGGAAAATGCTCCTTGTCACATTAGTGTGCATCCTACAAAAAGTGATCTCTTAATGTAAATTAAGAATAT
 961 TTTCATAATTGGAATATACTTTTCTTAAAAAAAAGGAACAGTTAGTTCTCATCTAGAATGAAAGTTCCATATATGCATTG
1041 GTGAATATATATGTATACACATACTTACATACTTATATGGGTATCTGTATAGATAATTTGTATTAGAGTATTATATAGCT
1121 TCTTAGTAGGGTCTCAAGTAAGTTTCATTTTTTTTATCTGGGCTATATACAGTCCTCAAATAAATAATGTCTTGATTTTA
1201 TTTCAGCAGGAATAATTTTATTTATTTTGCCTATTTATAATTAAAGTATTTTTCTTTAGTTTGAAAATGTGTATTAAAGT
1281 TACATTTTTGAGTTACAAGAGTCTTATAACTACTTGAATTTTTAGTTAAAATGTCTTAATGTAGGTTGTAGTCACTTTAG
1361 ATGGAAAATTACCTCACATCTGTTTTCTTCAGTATTACTTAAGATTGTTTATTTAGTGGTAGAGAGTTTTTTTTTTCAGC
1441 CTAGAGGCAGCTATTTTACCATCTGGTATTTATGGTCTAATTTGTATTTAAACATATGCACACATATAAAAGTTGATACT
1521 GTGGCAGTAAACTATTAAAAGTTTTCACTGTTCAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' aacucUCACGGU------AAUAGACCc 5'
               ||| :||      |||||||| 
Target 5' aagtaAGTTTCATTTTTTTTATCTGGg 3'
 1136 - 1162 150.00 -15.00
2 
miRNA  3' aaCUCUCACGGUA-----AUAGACCc 5'
            |||:  ||:||      |||||| 
Target 5' taGAGGCAGCTATTTTACCATCTGGt 3'
 1442 - 1467 123.00 -13.70
3 
miRNA  3' aacUCUCACGGUAAUAGACCc 5'
             ||| | :|||| |:||| 
Target 5' cccAGATTATCATTCTTTGGg 3'
 176 - 196 122.00 -12.90
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN31523372 13 COSMIC
COSN20088094 28 COSMIC
COSN23015317 39 COSMIC
COSN5847125 40 COSMIC
COSN32053464 48 COSMIC
COSN1082150 85 COSMIC
COSN31612918 105 COSMIC
COSN30146601 117 COSMIC
COSN31549645 165 COSMIC
COSN31480386 169 COSMIC
COSN31559307 183 COSMIC
COSN30116454 211 COSMIC
COSN5430042 303 COSMIC
COSN5430043 306 COSMIC
COSN31527761 433 COSMIC
COSN31556395 437 COSMIC
COSN30173668 500 COSMIC
COSN30173566 540 COSMIC
COSN31588945 543 COSMIC
COSN28645187 544 COSMIC
COSN31606973 568 COSMIC
COSN6129261 611 COSMIC
COSN17226036 952 COSMIC
COSN9841439 1073 COSMIC
COSN16436086 1168 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs142504944 2 dbSNP
rs199746594 4 dbSNP
rs1394283053 7 dbSNP
rs1435186663 8 dbSNP
rs767708286 15 dbSNP
rs773344454 16 dbSNP
rs760723354 19 dbSNP
rs565088805 20 dbSNP
rs1363605172 23 dbSNP
rs369661307 24 dbSNP
rs755468477 26 dbSNP
rs765533777 27 dbSNP
rs753039812 30 dbSNP
rs1281348139 34 dbSNP
rs1315707157 35 dbSNP
rs758055156 38 dbSNP
rs1317618976 40 dbSNP
rs777557325 41 dbSNP
rs1466389045 49 dbSNP
rs751162307 54 dbSNP
rs753913594 56 dbSNP
rs531143556 59 dbSNP
rs200701850 60 dbSNP
rs769709864 62 dbSNP
rs1357351275 67 dbSNP
rs186289188 69 dbSNP
rs567995177 73 dbSNP
rs111493733 75 dbSNP
rs1290285211 76 dbSNP
rs1346462258 81 dbSNP
rs773395427 86 dbSNP
rs755817967 97 dbSNP
rs760850088 99 dbSNP
rs1344100592 103 dbSNP
rs771025863 104 dbSNP
rs776634359 109 dbSNP
rs559709122 110 dbSNP
rs765771009 111 dbSNP
rs753063688 112 dbSNP
rs1010120763 115 dbSNP
rs1331332621 117 dbSNP
rs763878145 119 dbSNP
rs1272778528 120 dbSNP
rs1475103308 122 dbSNP
rs1254451696 126 dbSNP
rs751287233 127 dbSNP
rs1188520396 134 dbSNP
rs750986075 135 dbSNP
rs756920899 136 dbSNP
rs1206958166 139 dbSNP
rs780859507 142 dbSNP
rs1177727104 143 dbSNP
rs1410147534 146 dbSNP
rs1232549705 150 dbSNP
rs1042039716 154 dbSNP
rs1338496924 156 dbSNP
rs953406595 171 dbSNP
rs1286511094 182 dbSNP
rs1382571868 185 dbSNP
rs1360915040 195 dbSNP
rs987452541 197 dbSNP
rs758732393 204 dbSNP
rs71357660 216 dbSNP
rs1394523772 238 dbSNP
rs935423304 243 dbSNP
rs1018362649 250 dbSNP
rs1357449536 263 dbSNP
rs988237836 267 dbSNP
rs964162487 273 dbSNP
rs549031554 275 dbSNP
rs913096882 292 dbSNP
rs780452079 299 dbSNP
rs7240965 303 dbSNP
rs1043023863 304 dbSNP
rs983028430 305 dbSNP
rs1469892348 306 dbSNP
rs1253637363 307 dbSNP
rs1199568219 317 dbSNP
rs191277486 320 dbSNP
rs1255529351 321 dbSNP
rs937216353 322 dbSNP
rs1057202920 330 dbSNP
rs918186125 331 dbSNP
rs1294988765 335 dbSNP
rs971073051 337 dbSNP
rs1041978 349 dbSNP
rs937055377 356 dbSNP
rs1942918 358 dbSNP
rs914383592 363 dbSNP
rs1389883188 364 dbSNP
rs537293356 373 dbSNP
rs1441951578 374 dbSNP
rs1193154707 383 dbSNP
rs1395919108 383 dbSNP
rs1466853757 387 dbSNP
rs1331684532 389 dbSNP
rs899363524 392 dbSNP
rs1480200364 403 dbSNP
rs780715290 411 dbSNP
rs1041618361 413 dbSNP
rs77732188 419 dbSNP
rs1029095488 422 dbSNP
rs953633499 427 dbSNP
rs1341607069 431 dbSNP
rs1302206984 435 dbSNP
rs1218334182 442 dbSNP
rs1276696886 453 dbSNP
rs1320503848 455 dbSNP
rs181343195 460 dbSNP
rs149001141 464 dbSNP
rs552920759 465 dbSNP
rs572904263 469 dbSNP
rs545058893 473 dbSNP
rs988657611 475 dbSNP
rs915317667 476 dbSNP
rs1436958629 480 dbSNP
rs1376348988 483 dbSNP
rs1172186719 496 dbSNP
rs1477101904 497 dbSNP
rs968096940 509 dbSNP
rs1182457144 512 dbSNP
rs118066714 523 dbSNP
rs1249526106 527 dbSNP
rs1485953960 531 dbSNP
rs1027089439 543 dbSNP
rs1192925938 543 dbSNP
rs3826598 544 dbSNP
rs1352230086 546 dbSNP
rs1279561113 551 dbSNP
rs114858354 555 dbSNP
rs1350480402 556 dbSNP
rs1025218375 557 dbSNP
rs1057037759 558 dbSNP
rs561405337 566 dbSNP
rs1412925279 570 dbSNP
rs1170665256 589 dbSNP
rs916941588 617 dbSNP
rs940349970 621 dbSNP
rs926927156 626 dbSNP
rs530382215 629 dbSNP
rs1409712643 637 dbSNP
rs7240310 638 dbSNP
rs1475425173 642 dbSNP
rs143843017 645 dbSNP
rs1236621009 651 dbSNP
rs1402381245 659 dbSNP
rs898931017 660 dbSNP
rs1448436216 662 dbSNP
rs1284499366 665 dbSNP
rs914331805 670 dbSNP
rs994507813 670 dbSNP
rs1050562678 673 dbSNP
rs889275944 682 dbSNP
rs528105468 684 dbSNP
rs1009603260 690 dbSNP
rs945890052 692 dbSNP
rs770823107 693 dbSNP
rs763032410 695 dbSNP
rs1019178030 716 dbSNP
rs956953516 727 dbSNP
rs1041980136 731 dbSNP
rs1446275852 732 dbSNP
rs1401015869 739 dbSNP
rs774236204 740 dbSNP
rs943900406 749 dbSNP
rs759277656 753 dbSNP
rs1386480111 754 dbSNP
rs1235782008 758 dbSNP
rs899810903 771 dbSNP
rs1256649331 790 dbSNP
rs1353142215 791 dbSNP
rs931325018 791 dbSNP
rs3826599 799 dbSNP
rs1161301369 803 dbSNP
rs1476260081 804 dbSNP
rs980815746 807 dbSNP
rs1242382813 808 dbSNP
rs1187502660 815 dbSNP
rs571368595 822 dbSNP
rs536824219 827 dbSNP
rs1489122892 828 dbSNP
rs58665242 860 dbSNP
rs759482252 861 dbSNP
rs958524802 863 dbSNP
rs1025526043 883 dbSNP
rs1341859375 887 dbSNP
rs57686154 889 dbSNP
rs185902213 892 dbSNP
rs572441307 893 dbSNP
rs1036032297 894 dbSNP
rs1321477106 897 dbSNP
rs1395127162 899 dbSNP
rs1411484419 907 dbSNP
rs1419910067 910 dbSNP
rs535025708 912 dbSNP
rs930430307 918 dbSNP
rs1193785263 922 dbSNP
rs536095469 924 dbSNP
rs552856864 925 dbSNP
rs1246667054 928 dbSNP
rs1454566723 933 dbSNP
rs967491193 946 dbSNP
rs1275712678 949 dbSNP
rs1228113331 973 dbSNP
rs1293297812 987 dbSNP
rs1305868492 987 dbSNP
rs1365999056 990 dbSNP
rs1388717869 995 dbSNP
rs1302295929 997 dbSNP
rs1376205310 1000 dbSNP
rs889308803 1001 dbSNP
rs1273033476 1005 dbSNP
rs572891665 1011 dbSNP
rs1238090843 1012 dbSNP
rs1354901572 1022 dbSNP
rs977204453 1030 dbSNP
rs1254360166 1032 dbSNP
rs1376952765 1033 dbSNP
rs912353276 1037 dbSNP
rs538692412 1039 dbSNP
rs74255491 1046 dbSNP
rs1487404724 1057 dbSNP
rs1471477484 1062 dbSNP
rs1211223020 1077 dbSNP
rs921210068 1081 dbSNP
rs1482259130 1082 dbSNP
rs1009056612 1085 dbSNP
rs1211031516 1090 dbSNP
rs1311698313 1103 dbSNP
rs1040916120 1105 dbSNP
rs558758218 1107 dbSNP
rs1438479967 1111 dbSNP
rs1351094412 1114 dbSNP
rs1287628015 1116 dbSNP
rs1407812479 1117 dbSNP
rs1176241040 1119 dbSNP
rs1303078829 1127 dbSNP
rs1465173221 1134 dbSNP
rs931293805 1138 dbSNP
rs1400757157 1148 dbSNP
rs1413393011 1148 dbSNP
rs573004852 1148 dbSNP
rs892738351 1149 dbSNP
rs765366709 1156 dbSNP
rs575723889 1160 dbSNP
rs1022310831 1164 dbSNP
rs1259981810 1166 dbSNP
rs112680252 1178 dbSNP
rs1483085956 1180 dbSNP
rs1235933013 1183 dbSNP
rs1218099741 1184 dbSNP
rs1459799723 1186 dbSNP
rs544391956 1193 dbSNP
rs1326774351 1215 dbSNP
rs1226436593 1232 dbSNP
rs1336677339 1239 dbSNP
rs1313245724 1248 dbSNP
rs1395220084 1249 dbSNP
rs903845497 1257 dbSNP
rs1290232740 1262 dbSNP
rs1387217464 1272 dbSNP
rs1435224939 1272 dbSNP
rs1399859725 1276 dbSNP
rs1159093603 1291 dbSNP
rs7227934 1299 dbSNP
rs1311551974 1308 dbSNP
rs1166007292 1320 dbSNP
rs1423579795 1321 dbSNP
rs1033745590 1327 dbSNP
rs1188469074 1330 dbSNP
rs958815749 1338 dbSNP
rs1377818244 1339 dbSNP
rs894097632 1340 dbSNP
rs1206895782 1348 dbSNP
rs1469809466 1349 dbSNP
rs574941137 1351 dbSNP
rs1243844057 1352 dbSNP
rs1319657393 1355 dbSNP
rs758854744 1356 dbSNP
rs1224253343 1363 dbSNP
rs1021673738 1368 dbSNP
rs1024534136 1369 dbSNP
rs961996968 1374 dbSNP
rs1318034211 1377 dbSNP
rs34120135 1380 dbSNP
rs7245349 1383 dbSNP
rs1319647872 1395 dbSNP
rs1294604184 1399 dbSNP
rs1457750049 1404 dbSNP
rs1367023221 1405 dbSNP
rs1170718735 1413 dbSNP
rs1450392903 1423 dbSNP
rs1389764098 1424 dbSNP
rs11376390 1427 dbSNP
rs560808893 1427 dbSNP
rs778258920 1427 dbSNP
rs138203769 1428 dbSNP
rs1273351603 1437 dbSNP
rs1457036207 1438 dbSNP
rs1487391649 1441 dbSNP
rs551426467 1448 dbSNP
rs1252782142 1451 dbSNP
rs965194626 1452 dbSNP
rs1196431702 1454 dbSNP
rs975277630 1473 dbSNP
rs1294922887 1479 dbSNP
rs190664610 1483 dbSNP
rs2849431 1484 dbSNP
rs985873459 1485 dbSNP
rs1331144024 1493 dbSNP
rs1181751890 1521 dbSNP
rs1386636316 1525 dbSNP
rs1389195743 1535 dbSNP
rs7232296 1543 dbSNP
rs199734220 1545 dbSNP
rs200740224 1548 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM545212. RNA binding protein: AGO1. Condition:Control PAR-CLIP data was present in GSM545214. RNA binding protein: AGO3. Condition:Control PAR-CLIP data was present in GSM545217. RNA binding protein: AGO2. Condition:miR-7 transfection ...

- Hafner M; Landthaler M; Burger L; Khorshid et al., 2010, Cell.

Article - Hafner M; Landthaler M; Burger L; Khorshid et al.
- Cell, 2010
RNA transcripts are subject to posttranscriptional gene regulation involving hundreds of RNA-binding proteins (RBPs) and microRNA-containing ribonucleoprotein complexes (miRNPs) expressed in a cell-type dependent fashion. We developed a cell-based crosslinking approach to determine at high resolution and transcriptome-wide the binding sites of cellular RBPs and miRNPs. The crosslinked sites are revealed by thymidine to cytidine transitions in the cDNAs prepared from immunopurified RNPs of 4-thiouridine-treated cells. We determined the binding sites and regulatory consequences for several intensely studied RBPs and miRNPs, including PUM2, QKI, IGF2BP1-3, AGO/EIF2C1-4 and TNRC6A-C. Our study revealed that these factors bind thousands of sites containing defined sequence motifs and have distinct preferences for exonic versus intronic or coding versus untranslated transcript regions. The precise mapping of binding sites across the transcriptome will be critical to the interpretation of the rapidly emerging data on genetic variation between individuals and how these variations contribute to complex genetic diseases.
LinkOut: [PMID: 20371350]
CLIP-seq Support 1 for dataset GSM545212
Method / RBP PAR-CLIP / AGO1
Cell line / Condition HEK293 / Control
Location of target site ENST00000316660.6 | 3UTR | UUUCAUUUUUUUUAUCUGGGCUAUAUAC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 20371350 / GSE21578
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM545214
Method / RBP PAR-CLIP / AGO3
Cell line / Condition HEK293 / Control
Location of target site ENST00000316660.6 | 3UTR | UUUCAUUUUUUUUAUCUGGGCUAUAU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 20371350 / GSE21578
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM545217
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / miR-7 transfection
Location of target site ENST00000316660.6 | 3UTR | UUUCAUUUUUUUUAUCUGGGCUAUAUACA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 20371350 / GSE21578
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE28544 Breast cancer -0.755 1.0e-5 -0.744 1.5e-5 24 Click to see details
GSE28260 Renal cortex and medulla 0.865 6.7e-5 0.727 2.4e-3 13 Click to see details
GSE17498 Multiple myeloma -0.278 4.1e-2 -0.268 4.7e-2 40 Click to see details
GSE26953 Aortic valvular endothelial cells 0.343 5.0e-2 0.094 3.3e-1 24 Click to see details
GSE14794 Lymphoblastoid cells -0.155 7.2e-2 -0.084 2.2e-1 90 Click to see details
GSE42095 Differentiated embryonic stem cells -0.219 1.6e-1 0.053 4.1e-1 23 Click to see details
GSE32688 Pancreatic cancer -0.161 1.9e-1 -0.130 2.4e-1 32 Click to see details
GSE27834 Pluripotent stem cells 0.204 2.2e-1 0.282 1.4e-1 16 Click to see details
GSE38974 Chronic obstructive pulmonary disease -0.101 3.2e-1 -0.025 4.5e-1 25 Click to see details
GSE15076 Monocyte-derived dendritic cells -0.193 4.0e-1 0.000 5.0e-1 4 Click to see details
GSE19350 CNS germ cell tumors 0.077 4.1e-1 0.084 4.0e-1 12 Click to see details
GSE38226 Liver fibrosis -0.04 4.3e-1 0.092 3.5e-1 21 Click to see details
GSE21849 B cell lymphoma -0.028 4.4e-1 0.023 4.5e-1 29 Click to see details
GSE21687 Ependynoma primary tumors -0.018 4.4e-1 -0.035 3.9e-1 64 Click to see details
GSE17306 Multiple myeloma 0.02 4.5e-1 0.473 3.0e-4 49 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis 0.006 4.9e-1 -0.626 1.6e-3 20 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis 0.006 4.9e-1 -0.626 1.6e-3 20 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
BRCA 0.522 0.03 0.500 0.04 13 Click to see details
LIHC -0.554 0.08 -0.738 0.02 8 Click to see details
PRAD -0.576 0.09 -0.500 0.13 7 Click to see details
HNSC 0.405 0.21 0.600 0.1 6 Click to see details
PCPG 0.575 0.31 0.500 0.33 3 Click to see details
LUSC 0.285 0.32 0.000 0.5 5 Click to see details
UCEC 0.064 0.45 0.071 0.44 7 Click to see details
UCEC 0.064 0.45 0.071 0.44 7 Click to see details
UCEC 0.064 0.45 0.071 0.44 7 Click to see details
UCEC 0.064 0.45 0.071 0.44 7 Click to see details
UCEC 0.064 0.45 0.071 0.44 7 Click to see details
UCEC 0.064 0.45 0.071 0.44 7 Click to see details
UCEC 0.064 0.45 0.071 0.44 7 Click to see details
UCEC 0.064 0.45 0.071 0.44 7 Click to see details
UCEC 0.064 0.45 0.071 0.44 7 Click to see details
53 hsa-miR-488-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT003789 AR androgen receptor 4 1
MIRT041622 CYP2E1 cytochrome P450 family 2 subfamily E member 1 1 1
MIRT080581 PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 2 2
MIRT081895 KCTD15 potassium channel tetramerization domain containing 15 2 8
MIRT086202 HOXD13 homeobox D13 2 4
MIRT372238 MAK16 MAK16 homolog 2 2
MIRT443057 ENAM enamelin 2 2
MIRT445919 SHOC2 SHOC2, leucine rich repeat scaffold protein 2 2
MIRT457586 NCOA3 nuclear receptor coactivator 3 2 2
MIRT461689 ZNF426 zinc finger protein 426 2 2
MIRT463200 ZNF148 zinc finger protein 148 2 4
MIRT470582 POTEM POTE ankyrin domain family member M 2 2
MIRT470612 POTEG POTE ankyrin domain family member G 2 2
MIRT471142 PHF19 PHD finger protein 19 2 2
MIRT485233 PRICKLE1 prickle planar cell polarity protein 1 2 2
MIRT492251 SLC35F5 solute carrier family 35 member F5 2 2
MIRT495640 CDK1 cyclin dependent kinase 1 2 2
MIRT496379 ATP2B4 ATPase plasma membrane Ca2+ transporting 4 2 2
MIRT502257 HNRNPF heterogeneous nuclear ribonucleoprotein F 2 4
MIRT513392 TUBB4A tubulin beta 4A class IVa 2 2
MIRT516855 ATP5G1 ATP synthase, H+ transporting, mitochondrial Fo complex subunit C1 (subunit 9) 2 2
MIRT519449 CSTF1 cleavage stimulation factor subunit 1 2 2
MIRT520978 SPATA2 spermatogenesis associated 2 2 4
MIRT527525 CD59 CD59 molecule (CD59 blood group) 2 2
MIRT528206 NELFE negative elongation factor complex member E 2 2
MIRT528260 GPRIN2 G protein regulated inducer of neurite outgrowth 2 2 2
MIRT536670 IL6ST interleukin 6 signal transducer 2 2
MIRT536751 HOXD9 homeobox D9 2 2
MIRT544422 ZNF460 zinc finger protein 460 2 4
MIRT562453 CSDE1 cold shock domain containing E1 2 2
MIRT562635 ARL6IP1 ADP ribosylation factor like GTPase 6 interacting protein 1 2 2
MIRT566506 PAWR pro-apoptotic WT1 regulator 2 2
MIRT572230 ATG2A autophagy related 2A 2 2
MIRT613888 CRB2 crumbs 2, cell polarity complex component 2 2
MIRT615567 JPH2 junctophilin 2 2 2
MIRT615853 RASGRP1 RAS guanyl releasing protein 1 2 2
MIRT615938 MAP1LC3B microtubule associated protein 1 light chain 3 beta 2 2
MIRT617637 RXRA retinoid X receptor alpha 2 2
MIRT645856 AFF2 AF4/FMR2 family member 2 2 2
MIRT653531 SLC38A9 solute carrier family 38 member 9 2 2
MIRT653592 SLC35B3 solute carrier family 35 member B3 2 2
MIRT654756 PRKCB protein kinase C beta 2 2
MIRT657213 IGF1R insulin like growth factor 1 receptor 2 2
MIRT658747 ELAVL4 ELAV like RNA binding protein 4 2 2
MIRT690654 RPF2 ribosome production factor 2 homolog 2 2
MIRT691746 IKBKG inhibitor of nuclear factor kappa B kinase subunit gamma 2 2
MIRT692854 ZSWIM1 zinc finger SWIM-type containing 1 2 2
MIRT700080 RNF38 ring finger protein 38 2 2
MIRT704431 CTNNBIP1 catenin beta interacting protein 1 2 2
MIRT717145 DLEU1 deleted in lymphocytic leukemia 1 (non-protein coding) 2 2
MIRT718664 HNF4A hepatocyte nuclear factor 4 alpha 2 2
MIRT722739 BRMS1 breast cancer metastasis suppressor 1 2 2
MIRT733774 PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 2 0
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-488 Glucose NULL 5793 Quantitative real-time PCR endothelial cells 24394957 2014 down-regulated
miR-488 Diethylstilbestrol approved 448537 Microarray mammosphere-derived epithelial cells (MDEC) 19549897 2009 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-488 Doxorubicin 31703 NSC123127 approved resistant High Chronic Myelogenous Leukemia cell line (K562)
hsa-miR-488 Chemotherapy sensitive High Epithelial Ovarian Cancer tissue
hsa-miR-488 Cisplatin 5460033 NSC119875 approved resistant Low Non-Small Cell Lung Cancer cell line (A549, H1299)
hsa-miR-488 Daunorubicin 30323 NSC82151 approved resistant High Acute Promyelocytic Leukemia cell line (HL60)
hsa-miR-488 Vemurafenib 42611257 NSC761431 approved sensitive High Melanoma cell line (A375)
hsa-miR-488 Taxane 9548828 sensitive High Breast Cancer tissue
hsa-miR-488 Doxorubicin 31703 NSC123127 approved sensitive High Anaplastic Thyroid Cancer tissue
hsa-mir-488 Paclitaxel 36314 NSC125973 approved sensitive cell line (A2780)
hsa-mir-488 Fluorouracil 3385 NSC19893 approved resistant cell line (OE19)
hsa-miR-488 Sunitinib 5329102 NSC750690 approved resistant tissue (CardA)
hsa-miR-488 Pegylated interferon alpha+Ribavirin sensitive tissue (chronic hepatitis C)
hsa-miR-488 Doxorubicin 31703 NSC123127 approved resistant cell line (K562)
hsa-miR-488 Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-488-5p Osimertinib 71496458 NSC779217 approved sensitive cell line (PC9)
hsa-miR-488-5p Paclitaxel 36314 NSC125973 approved resistant cell line (A2780)
hsa-miR-488-5p Sunitinib 5329102 NSC750690 approved resistant tissue (CardB)
hsa-miR-488-5p Paclitaxel 36314 NSC125973 approved resistant cell line (PC3PR20)
hsa-miR-488-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-488-5p Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (100 ng/ml)
hsa-miR-488-5p Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (1500 ng/ml)

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