miRTarBase - #MIRT083315


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pre-miRNA Information
pre-miRNA hsa-mir-4500   
Genomic Coordinates chr13: 87618665 - 87618740
Description Homo sapiens miR-4500 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4500
Sequence 54| UGAGGUAGUAGUUUCUU |70
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1322800324 2 dbSNP
rs1401270256 3 dbSNP
rs1382127193 7 dbSNP
rs1156555764 9 dbSNP
rs1438864054 10 dbSNP
rs1379842540 13 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol ZCCHC3   
Synonyms C20orf99
Description zinc finger CCHC-type containing 3
Transcript NM_033089   
Expression
Putative miRNA Targets on ZCCHC3
3'UTR of ZCCHC3
(miRNA target sites are highlighted)		 
>ZCCHC3|NM_033089|3'UTR
   1 ACACCCGCCTGCCTGCCAGGGTGAACACACAGCCAGCTTATCCCTCTTAAGTGCCAAAACTTTTTTTTAAACCATTTTTT
  81 ATCGTTTTTGAAGGAGATCTTTTTAAAACCTACAAGAGACATCTCTCTATGCCTTCTTAAACCGAGTTTACTCCATTTCA
 161 GCCTGTTCTGAATTGGTGACTCTGTCACCAATAACGACTGCGGAGAACTGTAGCGTGCAGATGTGTTGCCCCTCCCTTTT
 241 AAAATTTTATTTTCGTTTTTCTATTGGGTATTTGTTTTGTTTCTTGTACTTTTTCTCTCTCTCCTTGCCCCCCTCCCGCC
 321 CTCCCCGCCCCATACCTTTTCTTCCCCTGGATTTTCACCCTTTGGGCTGCCTTGCTCATCTTTATGCCCCAGCACTAGGT
 401 ACGGGGCCCAACACGTGGTAGGCACTCCATCAGTGTTTGCTGAATTGAAAACATTGTTGACTGTGGCTTCTATCAGAGTG
 481 TCTACCTTTTGCAGCTCTTCCCCTCCCTCATTTAATTTGCTGCTTTTAATCTACGTGGTCTGAGAATTTGTGAAACCAGT
 561 GTTGTTAGAAGTGTATATAATCTGAATCAATAAGCTCTGAATGGTGGCCAAGGGCCTCTCTTATGGCACAAAGATGCATG
 641 GACTTCATGACAGCTCTTTTGGTGGCTCAGAAGCCATTTTTTATAGAATCATGGAATCTAGAATATTCCTGCTGGAAAGA
 721 ACCTGAGAGTTGGTTTGGACCAATTCCCTGGTTTTCCAGCAGATGAAACAGGCCCAAAGAGGTTAAATGACTGGGTGAAA
 801 ATCACATAGCTGTCTGGTGCCAGAGCCAGCCTATAGTAGAGTCCCCTGACCCCAAGCCCGGTGCTCATTCCACTACCTCT
 881 CACACTTCACAACAATTTCCTCAACACTTGAGGGCCCAGAAAGTCTGATCTCTCCAGAATGATCAGCCCAGAGGAATGCT
 961 GAGAAATCACCTGGAGGAGGGAGCAGAAAGAGAAGGTTTTTAAGGAGGGGCTTCTGAATACTTGGGAGATACGGAACGGA
1041 CCAAGGACCACACTCCAGGGTGCATTCGTTGCTCCCTGGGGCACCACTTCTGGATTACAGTGTGCCAGGTCCTTTGGAGG
1121 CCCTACCCCTTCCCCATTCATTGCCACCAGTGAGAAATGGGGGTGCCCCTGTGTAAAGAAACCTACCAAAGGTTTACATT
1201 TGCACCTTAGCCTCAATAGCTACGAACCCTAGAGAAGCAGCTAGCTGGAGCTCATGTGCAACTCCTGATTCTCAGGAGAA
1281 AGATGGATTTTAACCCAAAATTATGAGTGAGCTGTTAACTCTAAAATGTACTTGGGAGATAGGCCAAGCGAGAGGTCATG
1361 GGCCAACTAAGTGTTATCCAGTAGAAAAGACAGTACACTGCTTTTCTTTTAGTGTTTGCTTTTCCTTTGCTATATGTTTT
1441 GCTATTTCCTTGTGGCTTAGAATGTAAAATTGATTGTTAAAAGTTTTGTTCTGAATAAATATTTATCTTTTGTATTGCTA
1521 AAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' uucuuuGAUGAUGGAGu 5'
                | |||||||| 
Target 5' ctcattCCACTACCTCt 3'
 864 - 880 147.00 -10.90
2 
miRNA  3' uucUUUGAU-GAUGGAGu 5'
             |:| |: ||||||: 
Target 5' atcAGAGTGTCTACCTTt 3'
 472 - 489 130.00 -10.60
3 
miRNA  3' uuCUUUGAUGAUGGagu 5'
            |||||  |||||   
Target 5' aaGAAAC--CTACCaaa 3'
 1176 - 1190 115.00 -9.32
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30511536 7 COSMIC
COSN1082990 59 COSMIC
COSN13244990 69 COSMIC
COSN30525342 75 COSMIC
COSN30123952 100 COSMIC
COSN30116279 319 COSMIC
COSN15627012 332 COSMIC
COSN15627013 428 COSMIC
COSN30133479 433 COSMIC
COSN31548555 471 COSMIC
COSN30534195 612 COSMIC
COSN15627014 615 COSMIC
COSN15627015 632 COSMIC
COSN30544215 763 COSMIC
COSN31572242 806 COSMIC
COSN26637881 813 COSMIC
COSN26190232 909 COSMIC
COSN31482781 964 COSMIC
COSN31489569 964 COSMIC
COSN31540856 1033 COSMIC
COSN21903558 1035 COSMIC
COSN30112209 1068 COSMIC
COSN8610684 1086 COSMIC
COSN23396393 1194 COSMIC
COSN26708746 1221 COSMIC
COSN30143387 1225 COSMIC
COSN31489557 1306 COSMIC
COSN26585103 1351 COSMIC
COSN31529735 1371 COSMIC
COSN5968419 1403 COSMIC
COSN15627017 1425 COSMIC
COSN15627016 1429 COSMIC
COSN15627018 1493 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs763872038 4 dbSNP
rs751191179 6 dbSNP
rs371820165 7 dbSNP
rs1027913841 8 dbSNP
rs1206959284 11 dbSNP
rs1247628078 15 dbSNP
rs767113214 17 dbSNP
rs749900419 24 dbSNP
rs541476404 27 dbSNP
rs1232376398 30 dbSNP
rs780406252 31 dbSNP
rs1178246922 38 dbSNP
rs932517594 40 dbSNP
rs1046560 42 dbSNP
rs1455171892 44 dbSNP
rs1157855549 46 dbSNP
rs779108519 50 dbSNP
rs1201000522 61 dbSNP
rs1364271979 61 dbSNP
rs983687778 69 dbSNP
rs1461338953 70 dbSNP
rs1009423738 72 dbSNP
rs1464652242 72 dbSNP
rs1379848970 75 dbSNP
rs907555469 79 dbSNP
rs1021107005 85 dbSNP
rs1246577799 85 dbSNP
rs773297580 87 dbSNP
rs949725500 95 dbSNP
rs981225913 98 dbSNP
rs903643638 100 dbSNP
rs1342340492 103 dbSNP
rs143206307 110 dbSNP
rs1234952464 111 dbSNP
rs1033342766 113 dbSNP
rs1367774082 114 dbSNP
rs1389020332 121 dbSNP
rs1437488359 124 dbSNP
rs924483250 126 dbSNP
rs1294119648 130 dbSNP
rs991667512 131 dbSNP
rs937177959 137 dbSNP
rs1326177769 144 dbSNP
rs1429705488 147 dbSNP
rs867007805 155 dbSNP
rs543635316 156 dbSNP
rs1388655300 160 dbSNP
rs1170846748 162 dbSNP
rs1024572801 163 dbSNP
rs1219584053 167 dbSNP
rs1280513249 168 dbSNP
rs1186468120 169 dbSNP
rs1054256281 171 dbSNP
rs563611902 173 dbSNP
rs1332873255 180 dbSNP
rs568625842 192 dbSNP
rs945995933 199 dbSNP
rs111892073 202 dbSNP
rs982993778 203 dbSNP
rs908613350 206 dbSNP
rs902532413 209 dbSNP
rs548715833 211 dbSNP
rs941466437 214 dbSNP
rs1009286414 215 dbSNP
rs559258427 218 dbSNP
rs921231392 223 dbSNP
rs900550323 225 dbSNP
rs1409338192 231 dbSNP
rs932654944 233 dbSNP
rs1051432121 241 dbSNP
rs1390487632 243 dbSNP
rs1162213577 244 dbSNP
rs996262390 245 dbSNP
rs1474018101 255 dbSNP
rs528174354 256 dbSNP
rs1042256045 262 dbSNP
rs952170165 264 dbSNP
rs1206612060 269 dbSNP
rs903607997 271 dbSNP
rs1288917887 274 dbSNP
rs551106709 276 dbSNP
rs1208235442 291 dbSNP
rs983720367 294 dbSNP
rs1015561308 302 dbSNP
rs1000529446 304 dbSNP
rs1227854321 308 dbSNP
rs143844000 308 dbSNP
rs534402324 308 dbSNP
rs543148031 308 dbSNP
rs1286640631 313 dbSNP
rs894785004 313 dbSNP
rs1349625224 315 dbSNP
rs1384808169 316 dbSNP
rs1401155731 318 dbSNP
rs1280419736 319 dbSNP
rs1354034029 323 dbSNP
rs1202824194 328 dbSNP
rs1409134207 330 dbSNP
rs1313770513 331 dbSNP
rs1409176468 332 dbSNP
rs1046561 333 dbSNP
rs1246102235 333 dbSNP
rs1323550708 334 dbSNP
rs1236924527 336 dbSNP
rs1260243891 338 dbSNP
rs1487889823 341 dbSNP
rs1217333535 343 dbSNP
rs1196438206 344 dbSNP
rs1265043396 344 dbSNP
rs1013270373 347 dbSNP
rs1484595849 352 dbSNP
rs1208355780 356 dbSNP
rs138536096 357 dbSNP
rs1414015225 358 dbSNP
rs1224780739 359 dbSNP
rs1425207223 368 dbSNP
rs971094273 382 dbSNP
rs1156240756 385 dbSNP
rs185299499 388 dbSNP
rs981474126 392 dbSNP
rs1273624686 403 dbSNP
rs374576318 404 dbSNP
rs1362710871 407 dbSNP
rs34131242 407 dbSNP
rs1420837016 410 dbSNP
rs1300656404 417 dbSNP
rs1326096893 422 dbSNP
rs1374007996 424 dbSNP
rs1385743584 430 dbSNP
rs1160627336 436 dbSNP
rs1024959279 442 dbSNP
rs1424362474 446 dbSNP
rs188172008 453 dbSNP
rs1462629141 462 dbSNP
rs572871638 463 dbSNP
rs989845810 464 dbSNP
rs971701251 468 dbSNP
rs1463731836 471 dbSNP
rs1354573948 475 dbSNP
rs1004787800 482 dbSNP
rs1311748458 485 dbSNP
rs1240756355 487 dbSNP
rs146779563 492 dbSNP
rs751424700 502 dbSNP
rs1345677743 504 dbSNP
rs1209098401 510 dbSNP
rs1237850231 530 dbSNP
rs962879913 533 dbSNP
rs974125881 534 dbSNP
rs1362540223 541 dbSNP
rs945860482 545 dbSNP
rs954012411 550 dbSNP
rs986850299 553 dbSNP
rs1358082949 559 dbSNP
rs1332031304 564 dbSNP
rs1436542145 572 dbSNP
rs1439828532 574 dbSNP
rs1395407898 578 dbSNP
rs549939790 587 dbSNP
rs1160945020 589 dbSNP
rs1167708839 589 dbSNP
rs759314956 591 dbSNP
rs1289128502 598 dbSNP
rs139935493 602 dbSNP
rs1187387202 604 dbSNP
rs1177171134 610 dbSNP
rs945350428 612 dbSNP
rs1042697054 617 dbSNP
rs1440270921 619 dbSNP
rs1486271209 623 dbSNP
rs944728742 624 dbSNP
rs1297866165 638 dbSNP
rs925080885 639 dbSNP
rs1040818710 643 dbSNP
rs536111709 653 dbSNP
rs767243172 663 dbSNP
rs1449029998 666 dbSNP
rs936521008 667 dbSNP
rs192747351 674 dbSNP
rs1290931548 677 dbSNP
rs1368621830 677 dbSNP
rs996283177 681 dbSNP
rs1416145825 683 dbSNP
rs572359788 684 dbSNP
rs1307419691 693 dbSNP
rs1279060184 704 dbSNP
rs1427568412 707 dbSNP
rs887956633 709 dbSNP
rs1313799346 710 dbSNP
rs1005425290 714 dbSNP
rs1411956202 715 dbSNP
rs1190117466 716 dbSNP
rs1013656464 719 dbSNP
rs545876059 720 dbSNP
rs1475614707 723 dbSNP
rs752297363 724 dbSNP
rs1201980603 728 dbSNP
rs755752964 734 dbSNP
rs183507323 756 dbSNP
rs1046104961 759 dbSNP
rs1457961754 760 dbSNP
rs1252284798 769 dbSNP
rs1179920563 774 dbSNP
rs558325924 776 dbSNP
rs1291103031 795 dbSNP
rs188169139 804 dbSNP
rs1355607278 806 dbSNP
rs1192342255 816 dbSNP
rs1287583524 818 dbSNP
rs1427670319 821 dbSNP
rs1408609456 822 dbSNP
rs6047890 832 dbSNP
rs1034459530 838 dbSNP
rs142800891 845 dbSNP
rs1015867694 847 dbSNP
rs1180597999 850 dbSNP
rs563459869 850 dbSNP
rs962849559 856 dbSNP
rs73572500 858 dbSNP
rs1487750422 861 dbSNP
rs1215191330 862 dbSNP
rs1323894020 875 dbSNP
rs1334847899 877 dbSNP
rs1266975987 889 dbSNP
rs1393921426 895 dbSNP
rs1236312560 899 dbSNP
rs1307699556 903 dbSNP
rs1028399989 906 dbSNP
rs1368526735 924 dbSNP
rs914295112 930 dbSNP
rs967193835 950 dbSNP
rs1441953700 955 dbSNP
rs1387934262 957 dbSNP
rs752955443 961 dbSNP
rs542858627 972 dbSNP
rs1212547731 977 dbSNP
rs1277358395 983 dbSNP
rs756526310 985 dbSNP
rs1431747223 986 dbSNP
rs912524662 995 dbSNP
rs538374451 996 dbSNP
rs978004424 997 dbSNP
rs1247071624 998 dbSNP
rs528128129 1006 dbSNP
rs115623645 1008 dbSNP
rs1261179104 1010 dbSNP
rs1039603111 1017 dbSNP
rs564666167 1021 dbSNP
rs921943855 1023 dbSNP
rs1424790301 1024 dbSNP
rs931939898 1029 dbSNP
rs1316589514 1032 dbSNP
rs1383987304 1033 dbSNP
rs1385786311 1034 dbSNP
rs916321795 1038 dbSNP
rs949125591 1039 dbSNP
rs1049180704 1040 dbSNP
rs530493281 1054 dbSNP
rs1449311475 1068 dbSNP
rs753365032 1073 dbSNP
rs1190594843 1079 dbSNP
rs1004975429 1083 dbSNP
rs758866968 1085 dbSNP
rs907355778 1091 dbSNP
rs184674478 1101 dbSNP
rs1034540277 1106 dbSNP
rs958379381 1110 dbSNP
rs1011164846 1124 dbSNP
rs995668330 1136 dbSNP
rs1341275925 1137 dbSNP
rs1028537200 1151 dbSNP
rs570191338 1152 dbSNP
rs1021333613 1159 dbSNP
rs529564186 1161 dbSNP
rs889952246 1162 dbSNP
rs1312125972 1165 dbSNP
rs1220060472 1172 dbSNP
rs967564718 1179 dbSNP
rs1377791691 1186 dbSNP
rs977193242 1187 dbSNP
rs1314083575 1193 dbSNP
rs1429447196 1194 dbSNP
rs1394788334 1211 dbSNP
rs150607885 1213 dbSNP
rs1476200430 1215 dbSNP
rs1373338833 1216 dbSNP
rs566236348 1220 dbSNP
rs975756886 1224 dbSNP
rs921144601 1225 dbSNP
rs931979308 1228 dbSNP
rs14181 1230 dbSNP
rs190528845 1233 dbSNP
rs1032206421 1245 dbSNP
rs957981806 1246 dbSNP
rs990700758 1255 dbSNP
rs558164311 1259 dbSNP
rs769152727 1276 dbSNP
rs1231513528 1283 dbSNP
rs940795360 1284 dbSNP
rs1216603329 1289 dbSNP
rs1294370816 1295 dbSNP
rs1409776044 1306 dbSNP
rs775264314 1308 dbSNP
rs34756351 1323 dbSNP
rs1331262312 1337 dbSNP
rs1264329277 1339 dbSNP
rs1396766746 1342 dbSNP
rs1489504830 1342 dbSNP
rs374936391 1342 dbSNP
rs571794160 1346 dbSNP
rs1163838250 1349 dbSNP
rs1186040442 1350 dbSNP
rs1419401395 1350 dbSNP
rs1036436171 1351 dbSNP
rs115121514 1352 dbSNP
rs1473262086 1361 dbSNP
rs181752957 1366 dbSNP
rs2031 1368 dbSNP
rs757993576 1370 dbSNP
rs75572491 1374 dbSNP
rs1037407286 1378 dbSNP
rs894694975 1379 dbSNP
rs542446075 1385 dbSNP
rs1011774706 1390 dbSNP
rs1273910585 1394 dbSNP
rs931511612 1395 dbSNP
rs553265754 1401 dbSNP
rs1158036838 1408 dbSNP
rs902828275 1411 dbSNP
rs1050011332 1417 dbSNP
rs999026413 1420 dbSNP
rs1324728012 1421 dbSNP
rs1019338261 1422 dbSNP
rs371945893 1428 dbSNP
rs965592484 1433 dbSNP
rs1395972120 1437 dbSNP
rs1164982728 1443 dbSNP
rs1399658220 1445 dbSNP
rs748344908 1450 dbSNP
rs889930321 1451 dbSNP
rs1394284507 1454 dbSNP
rs975211740 1455 dbSNP
rs1191926380 1462 dbSNP
rs139209694 1474 dbSNP
rs1019677136 1476 dbSNP
rs1445411814 1480 dbSNP
rs149967120 1485 dbSNP
rs1224834791 1487 dbSNP
rs1344709383 1491 dbSNP
rs984020819 1499 dbSNP
rs909242076 1512 dbSNP
rs1326252176 1515 dbSNP
rs940673724 1516 dbSNP
rs958040446 1519 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Disease 85364.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM1065667. RNA binding protein: AGO1. Condition:4-thiouridine ...

- Memczak S; Jens M; Elefsinioti A; Torti F; et al., 2013, Nature.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' uucuuugaUGAUGGAGu 5'
                  |||||||| 
Target 5' -------cACUACCUCu 3'
 		1 - 10
2 
miRNA  3' uucuUUGAUGAUGGAGu 5'
              ||| |:| |||| 
Target 5' ucacAACAAUUUCCUCa 3'
 		17 - 33
Article - Memczak S; Jens M; Elefsinioti A; Torti F; et al.
- Nature, 2013
Circular RNAs (circRNAs) in animals are an enigmatic class of RNA with unknown function. To explore circRNAs systematically, we sequenced and computationally analysed human, mouse and nematode RNA. We detected thousands of well-expressed, stable circRNAs, often showing tissue/developmental-stage-specific expression. Sequence analysis indicated important regulatory functions for circRNAs. We found that a human circRNA, antisense to the cerebellar degeneration-related protein 1 transcript (CDR1as), is densely bound by microRNA (miRNA) effector complexes and harbours 63 conserved binding sites for the ancient miRNA miR-7. Further analyses indicated that CDR1as functions to bind miR-7 in neuronal tissues. Human CDR1as expression in zebrafish impaired midbrain development, similar to knocking down miR-7, suggesting that CDR1as is a miRNA antagonist with a miRNA-binding capacity ten times higher than any other known transcript. Together, our data provide evidence that circRNAs form a large class of post-transcriptional regulators. Numerous circRNAs form by head-to-tail splicing of exons, suggesting previously unrecognized regulatory potential of coding sequences.
LinkOut: [PMID: 23446348]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HCT116
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in ERX177612. RNA binding protein: AGO2. Condition:p53_V_AGO_CLIP_3_2 PAR-CLIP data was present in ERX177624. RNA binding protein: AGO2. Condition:p53_V_AGO_CLIP_4_2 PAR-CLIP data was present in ERX177600. RNA binding protein: AGO2. Condition:p53_V_Ago_CLIP_2_2 PAR-CLIP data was present in ERX177604. RNA binding protein: AGO2. Condition:p53_V_AGO_CLIP_2_6 PAR-CLIP data was present in ERX177616. RNA binding protein: AGO2. Condition:p53_V_AGO_CLIP_3_6 PAR-CLIP data was present in ERX177628. RNA binding protein: AGO2. Condition:p53_V_AGO_CLIP_4_6 ...

- Krell J; Stebbing J; Carissimi C; Dabrowska et al., 2016, Genome research.

Article - Krell J; Stebbing J; Carissimi C; Dabrowska et al.
- Genome research, 2016
DNA damage activates TP53-regulated surveillance mechanisms that are crucial in suppressing tumorigenesis. TP53 orchestrates these responses directly by transcriptionally modulating genes, including microRNAs (miRNAs), and by regulating miRNA biogenesis through interacting with the DROSHA complex. However, whether the association between miRNAs and AGO2 is regulated following DNA damage is not yet known. Here, we show that, following DNA damage, TP53 interacts with AGO2 to induce or reduce AGO2's association of a subset of miRNAs, including multiple let-7 family members. Furthermore, we show that specific mutations in TP53 decrease rather than increase the association of let-7 family miRNAs, reducing their activity without preventing TP53 from interacting with AGO2. This is consistent with the oncogenic properties of these mutants. Using AGO2 RIP-seq and PAR-CLIP-seq, we show that the DNA damage-induced increase in binding of let-7 family members to the RISC complex is functional. We unambiguously determine the global miRNA-mRNA interaction networks involved in the DNA damage response, validating them through the identification of miRNA-target chimeras formed by endogenous ligation reactions. We find that the target complementary region of the let-7 seed tends to have highly fixed positions and more variable ones. Additionally, we observe that miRNAs, whose cellular abundance or differential association with AGO2 is regulated by TP53, are involved in an intricate network of regulatory feedback and feedforward circuits. TP53-mediated regulation of AGO2-miRNA interaction represents a new mechanism of miRNA regulation in carcinogenesis.
LinkOut: [PMID: 26701625]
CLIP-seq Support 1 for dataset GSM1065667
Method / RBP PAR-CLIP / AGO1
Cell line / Condition HEK293 / 4-thiouridine, ML_MM_6
Location of target site ENST00000382352.3 | 3UTR | CACUACCUCUCACACUUCACAACAAUUUCCUCAACACUUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23446348 / GSE43573
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
278 hsa-miR-4500 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT063205 ADIPOR2 adiponectin receptor 2 2 2
MIRT065701 ESPL1 extra spindle pole bodies like 1, separase 2 4
MIRT066489 HMGA2 high mobility group AT-hook 2 2 4
MIRT067415 TMTC3 transmembrane and tetratricopeptide repeat containing 3 2 2
MIRT068169 TXLNA taxilin alpha 2 2
MIRT068540 NHLRC3 NHL repeat containing 3 2 6
MIRT068798 FNDC3A fibronectin type III domain containing 3A 2 2
MIRT073020 ARID3B AT-rich interaction domain 3B 2 6
MIRT073683 IGF1R insulin like growth factor 1 receptor 2 8
MIRT076241 SMCR8 Smith-Magenis syndrome chromosome region, candidate 8 2 6
MIRT077628 IGF2BP1 insulin like growth factor 2 mRNA binding protein 1 2 2
MIRT080409 ONECUT2 one cut homeobox 2 2 2
MIRT083315 ZCCHC3 zinc finger CCHC-type containing 3 2 2
MIRT084989 BACH1 BTB domain and CNC homolog 1 2 2
MIRT094172 PCGF3 polycomb group ring finger 3 2 6
MIRT094475 SMARCAD1 SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1 2 4
MIRT095781 GRPEL2 GrpE like 2, mitochondrial 2 10
MIRT100105 ABT1 activator of basal transcription 1 2 8
MIRT112254 MDM4 MDM4, p53 regulator 2 4
MIRT118595 STK4 serine/threonine kinase 4 2 2
MIRT120932 PDE12 phosphodiesterase 12 2 8
MIRT123336 CALU calumenin 2 2
MIRT123991 POLR3D RNA polymerase III subunit D 2 2
MIRT152317 TNFSF9 TNF superfamily member 9 2 2
MIRT153921 NCOA3 nuclear receptor coactivator 3 2 2
MIRT168608 HMGA1 high mobility group AT-hook 1 2 4
MIRT180614 CRY2 cryptochrome circadian clock 2 2 2
MIRT187726 SUOX sulfite oxidase 2 2
MIRT191415 NAA30 N(alpha)-acetyltransferase 30, NatC catalytic subunit 2 2
MIRT193113 MAPK6 mitogen-activated protein kinase 6 2 2
MIRT215732 C5ORF51 chromosome 5 open reading frame 51 2 10
MIRT218822 CDKN1A cyclin dependent kinase inhibitor 1A 2 2
MIRT240344 UBXN2B UBX domain protein 2B 2 2
MIRT243480 TRIM71 tripartite motif containing 71 2 2
MIRT244088 EDN1 endothelin 1 2 2
MIRT252341 SALL3 spalt like transcription factor 3 2 2
MIRT255327 CDV3 CDV3 homolog 2 2
MIRT259295 PGRMC1 progesterone receptor membrane component 1 2 2
MIRT259499 TXLNG taxilin gamma 2 2
MIRT260715 CLDN12 claudin 12 2 6
MIRT264701 C11ORF57 chromosome 11 open reading frame 57 2 4
MIRT266228 PEX11B peroxisomal biogenesis factor 11 beta 2 2
MIRT266635 CHTOP chromatin target of PRMT1 2 2
MIRT268847 C1ORF21 chromosome 1 open reading frame 21 2 2
MIRT284540 PDP2 pyruvate dehyrogenase phosphatase catalytic subunit 2 2 2
MIRT294453 ZNF264 zinc finger protein 264 2 2
MIRT297023 RRM2 ribonucleotide reductase regulatory subunit M2 2 2
MIRT297451 SLC20A1 solute carrier family 20 member 1 2 4
MIRT300049 BZW1 basic leucine zipper and W2 domains 1 2 4
MIRT300907 KREMEN1 kringle containing transmembrane protein 1 2 2
MIRT303328 MXD1 MAX dimerization protein 1 2 2
MIRT309858 NAT8L N-acetyltransferase 8 like 2 2
MIRT322434 PPP2R2A protein phosphatase 2 regulatory subunit Balpha 2 2
MIRT324742 ACER2 alkaline ceramidase 2 2 2
MIRT402068 ATP6V1F ATPase H+ transporting V1 subunit F 2 4
MIRT442014 NDUFA4P1 NDUFA4, mitochondrial complex associated pseudogene 1 2 2
MIRT445653 ATP6V1G1 ATPase H+ transporting V1 subunit G1 2 6
MIRT447131 KIF27 kinesin family member 27 2 2
MIRT448262 ZNF774 zinc finger protein 774 2 2
MIRT449002 ANKRD46 ankyrin repeat domain 46 2 2
MIRT449949 FMNL3 formin like 3 2 2
MIRT451150 C19orf53 chromosome 19 open reading frame 53 2 2
MIRT451620 MEIS3P1 Meis homeobox 3 pseudogene 1 2 2
MIRT451689 C1RL complement C1r subcomponent like 2 2
MIRT452087 NUCB2 nucleobindin 2 2 2
MIRT452427 QDPR quinoid dihydropteridine reductase 2 2
MIRT452938 DISC1 disrupted in schizophrenia 1 2 2
MIRT453397 RHD Rh blood group D antigen 2 6
MIRT454159 HIST1H2BK histone cluster 1 H2B family member k 2 2
MIRT454275 FXN frataxin 2 2
MIRT454535 RABL2A RAB, member of RAS oncogene family like 2A 2 2
MIRT454849 ACOT9 acyl-CoA thioesterase 9 2 4
MIRT455671 GLO1 glyoxalase I 2 2
MIRT457243 RABL2B RAB, member of RAS oncogene family like 2B 2 2
MIRT457671 ZNF587 zinc finger protein 587 2 2
MIRT457882 THEM6 thioesterase superfamily member 6 2 4
MIRT458012 MRPL12 mitochondrial ribosomal protein L12 2 2
MIRT458275 FUT10 fucosyltransferase 10 2 2
MIRT459732 RRM1 ribonucleotide reductase catalytic subunit M1 2 2
MIRT460447 NOM1 nucleolar protein with MIF4G domain 1 2 4
MIRT460495 FAM105A family with sequence similarity 105 member A 2 6
MIRT460933 NOA1 nitric oxide associated 1 2 4
MIRT461088 OPA3 OPA3, outer mitochondrial membrane lipid metabolism regulator 2 2
MIRT461164 SLC11A2 solute carrier family 11 member 2 2 4
MIRT461360 COL8A1 collagen type VIII alpha 1 chain 2 2
MIRT462377 YAE1D1 Yae1 domain containing 1 2 2
MIRT462775 ZNF8 zinc finger protein 8 2 2
MIRT463426 ZC3HAV1L zinc finger CCCH-type containing, antiviral 1 like 2 2
MIRT463656 YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta 2 2
MIRT464260 VCL vinculin 2 2
MIRT465121 TSC22D2 TSC22 domain family member 2 2 4
MIRT466190 TMED5 transmembrane p24 trafficking protein 5 2 4
MIRT466728 SYNJ2BP synaptojanin 2 binding protein 2 2
MIRT469098 RNF144B ring finger protein 144B 2 2
MIRT469718 RAB40C RAB40C, member RAS oncogene family 2 2
MIRT470422 PPP1R15B protein phosphatase 1 regulatory subunit 15B 2 2
MIRT470684 POLR2D RNA polymerase II subunit D 2 4
MIRT470866 PLXND1 plexin D1 2 2
MIRT471269 PGM2L1 phosphoglucomutase 2 like 1 2 2
MIRT471960 NR6A1 nuclear receptor subfamily 6 group A member 1 2 2
MIRT472677 NAA20 N(alpha)-acetyltransferase 20, NatB catalytic subunit 2 2
MIRT472735 MTUS1 microtubule associated scaffold protein 1 2 6
MIRT473132 MLLT10 MLLT10, histone lysine methyltransferase DOT1L cofactor 2 2
MIRT473237 SMCR7L mitochondrial elongation factor 1 2 5
MIRT473824 MAP2K7 mitogen-activated protein kinase kinase 7 2 2
MIRT473935 LYN LYN proto-oncogene, Src family tyrosine kinase 2 2
MIRT474020 LRRC20 leucine rich repeat containing 20 2 2
MIRT474504 KLHDC8B kelch domain containing 8B 2 2
MIRT474762 KIAA0930 KIAA0930 2 2
MIRT474912 KCTD21 potassium channel tetramerization domain containing 21 2 2
MIRT475327 IFNLR1 interferon lambda receptor 1 2 2
MIRT475374 ICOSLG inducible T-cell costimulator ligand 2 2
MIRT475729 HERPUD1 homocysteine inducible ER protein with ubiquitin like domain 1 2 4
MIRT476544 GABPB1 GA binding protein transcription factor beta subunit 1 2 4
MIRT476982 FAM83G family with sequence similarity 83 member G 2 4
MIRT477539 EIF4G2 eukaryotic translation initiation factor 4 gamma 2 2 4
MIRT477676 EFHD2 EF-hand domain family member D2 2 2
MIRT479751 CCND1 cyclin D1 2 2
MIRT481189 ATXN7L3B ataxin 7 like 3B 2 4
MIRT481235 ATXN7L3 ataxin 7 like 3 2 2
MIRT481358 ATG9A autophagy related 9A 2 2
MIRT481383 ATG12 autophagy related 12 2 2
MIRT481647 AREL1 apoptosis resistant E3 ubiquitin protein ligase 1 2 2
MIRT481843 AP1S1 adaptor related protein complex 1 sigma 1 subunit 2 2
MIRT482179 AHR aryl hydrocarbon receptor 2 2
MIRT482215 AHCYL2 adenosylhomocysteinase like 2 2 2
MIRT485301 PLAGL2 PLAG1 like zinc finger 2 2 2
MIRT486654 ZNF28 zinc finger protein 28 2 2
MIRT489409 TUBB2A tubulin beta 2A class IIa 2 2
MIRT491861 ZBTB5 zinc finger and BTB domain containing 5 2 8
MIRT492217 SOCS1 suppressor of cytokine signaling 1 2 2
MIRT492632 PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 2 2
MIRT493320 LIMD2 LIM domain containing 2 2 2
MIRT493897 FAM43A family with sequence similarity 43 member A 2 4
MIRT494259 CEP120 centrosomal protein 120 2 2
MIRT494681 ARID3A AT-rich interaction domain 3A 2 2
MIRT495963 TBC1D19 TBC1 domain family member 19 2 2
MIRT496117 SNX17 sorting nexin 17 2 2
MIRT497870 SLC12A7 solute carrier family 12 member 7 2 2
MIRT498115 PLEKHO1 pleckstrin homology domain containing O1 2 4
MIRT499400 PLCG2 phospholipase C gamma 2 2 4
MIRT499489 GGA3 golgi associated, gamma adaptin ear containing, ARF binding protein 3 2 2
MIRT499648 SDR42E1 short chain dehydrogenase/reductase family 42E, member 1 2 2
MIRT499937 MFSD8 major facilitator superfamily domain containing 8 2 2
MIRT499993 HIST1H2BD histone cluster 1 H2B family member d 2 4
MIRT500821 THBS1 thrombospondin 1 2 3
MIRT500900 STRN striatin 2 4
MIRT501111 SLC5A6 solute carrier family 5 member 6 2 4
MIRT501179 SLC10A7 solute carrier family 10 member 7 2 6
MIRT501206 SUMO1 small ubiquitin-like modifier 1 2 2
MIRT501249 SEMA4C semaphorin 4C 2 6
MIRT501334 RNFT1 ring finger protein, transmembrane 1 2 2
MIRT501357 RNF44 ring finger protein 44 2 4
MIRT501394 RBFOX2 RNA binding protein, fox-1 homolog 2 2 10
MIRT501437 RAB11FIP4 RAB11 family interacting protein 4 2 2
MIRT501749 NSD1 nuclear receptor binding SET domain protein 1 2 2
MIRT501939 MBD2 methyl-CpG binding domain protein 2 2 8
MIRT502104 KPNA5 karyopherin subunit alpha 5 2 8
MIRT502123 KMT2D lysine methyltransferase 2D 2 4
MIRT502787 CEP135 centrosomal protein 135 2 2
MIRT502839 CELF1 CUGBP Elav-like family member 1 2 2
MIRT504783 C12orf4 chromosome 12 open reading frame 4 2 2
MIRT505020 ZNF644 zinc finger protein 644 2 2
MIRT505577 SMC1A structural maintenance of chromosomes 1A 2 6
MIRT506359 NUP155 nucleoporin 155 2 6
MIRT506936 IGDCC4 immunoglobulin superfamily DCC subclass member 4 2 6
MIRT507248 FIGN fidgetin, microtubule severing factor 2 8
MIRT507691 COIL coilin 2 6
MIRT508397 C1orf210 chromosome 1 open reading frame 210 2 6
MIRT508660 DIABLO diablo IAP-binding mitochondrial protein 2 4
MIRT508927 AK4 adenylate kinase 4 2 4
MIRT510387 ZNF566 zinc finger protein 566 2 6
MIRT510521 YOD1 YOD1 deubiquitinase 2 6
MIRT511381 IKZF3 IKAROS family zinc finger 3 2 4
MIRT512740 CD59 CD59 molecule (CD59 blood group) 2 4
MIRT515949 C9orf156 tRNA methyltransferase O 2 2
MIRT516078 ZBTB8OS zinc finger and BTB domain containing 8 opposite strand 2 4
MIRT521392 RDX radixin 2 4
MIRT522344 NCKIPSD NCK interacting protein with SH3 domain 2 4
MIRT523623 FZD9 frizzled class receptor 9 2 4
MIRT523728 FBXW2 F-box and WD repeat domain containing 2 2 4
MIRT523981 DVL3 dishevelled segment polarity protein 3 2 2
MIRT524108 DNA2 DNA replication helicase/nuclease 2 2 2
MIRT525722 SOD2 superoxide dismutase 2 2 2
MIRT527758 RRAD RRAD, Ras related glycolysis inhibitor and calcium channel regulator 2 2
MIRT529722 OPRL1 opioid related nociceptin receptor 1 2 2
MIRT533183 WASL Wiskott-Aldrich syndrome like 2 6
MIRT536373 LEFTY1 left-right determination factor 1 2 2
MIRT543781 RBM12B RNA binding motif protein 12B 2 4
MIRT543863 SLC16A9 solute carrier family 16 member 9 2 2
MIRT545383 PM20D2 peptidase M20 domain containing 2 2 2
MIRT545895 ZNF200 zinc finger protein 200 2 4
MIRT546328 TGFBR3 transforming growth factor beta receptor 3 2 2
MIRT547374 MSI2 musashi RNA binding protein 2 2 2
MIRT547577 LRIG3 leucine rich repeats and immunoglobulin like domains 3 2 4
MIRT547834 IGF2BP3 insulin like growth factor 2 mRNA binding protein 3 2 4
MIRT548260 FBXL20 F-box and leucine rich repeat protein 20 2 2
MIRT548342 EPHA4 EPH receptor A4 2 2
MIRT548539 DUSP1 dual specificity phosphatase 1 2 2
MIRT548554 DNAL1 dynein axonemal light chain 1 2 2
MIRT548787 COLEC12 collectin subfamily member 12 2 2
MIRT548976 CCNT2 cyclin T2 2 2
MIRT549026 CBX5 chromobox 5 2 2
MIRT549213 BEND4 BEN domain containing 4 2 4
MIRT549759 ZNF611 zinc finger protein 611 2 6
MIRT549794 KIAA0391 KIAA0391 2 2
MIRT549843 ECHDC1 ethylmalonyl-CoA decarboxylase 1 2 2
MIRT550723 PMPCA peptidase, mitochondrial processing alpha subunit 2 4
MIRT550893 ACTA1 actin, alpha 1, skeletal muscle 2 2
MIRT551277 MCF2L2 MCF.2 cell line derived transforming sequence-like 2 2 6
MIRT551313 GSG2 histone H3 associated protein kinase 2 6
MIRT551928 AKAP8 A-kinase anchoring protein 8 2 4
MIRT551998 RAD18 RAD18, E3 ubiquitin protein ligase 2 2
MIRT552405 ZNF460 zinc finger protein 460 2 4
MIRT553016 USP38 ubiquitin specific peptidase 38 2 2
MIRT555544 PLEKHA3 pleckstrin homology domain containing A3 2 2
MIRT555716 PDZD8 PDZ domain containing 8 2 2
MIRT557377 HAND1 heart and neural crest derivatives expressed 1 2 2
MIRT557957 FAM222B family with sequence similarity 222 member B 2 2
MIRT559086 C19orf47 chromosome 19 open reading frame 47 2 4
MIRT559493 ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 2 2
MIRT561777 PEG10 paternally expressed 10 2 2
MIRT564396 EMILIN2 elastin microfibril interfacer 2 2 4
MIRT565445 SURF4 surfeit 4 2 2
MIRT566514 PARP16 poly(ADP-ribose) polymerase family member 16 2 2
MIRT567437 GNG5 G protein subunit gamma 5 2 2
MIRT567712 E2F6 E2F transcription factor 6 2 2
MIRT568652 ABHD17C abhydrolase domain containing 17C 2 2
MIRT569493 THYN1 thymocyte nuclear protein 1 2 2
MIRT573816 TGOLN2 trans-golgi network protein 2 2 2
MIRT574358 ZBTB37 zinc finger and BTB domain containing 37 2 2
MIRT574754 GOLGA4 golgin A4 2 2
MIRT574791 FAM104A family with sequence similarity 104 member A 2 2
MIRT576081 Poteg POTE ankyrin domain family, member G 2 2
MIRT576813 Thbs1 thrombospondin 1 2 3
MIRT616365 RWDD1 RWD domain containing 1 2 2
MIRT617846 FMO4 flavin containing monooxygenase 4 2 2
MIRT642389 ZNF556 zinc finger protein 556 2 2
MIRT680514 PRIM2 DNA primase subunit 2 2 2
MIRT680542 ZNF584 zinc finger protein 584 2 2
MIRT680795 ZNF578 zinc finger protein 578 2 2
MIRT680833 ARL8B ADP ribosylation factor like GTPase 8B 2 2
MIRT681136 INTS7 integrator complex subunit 7 2 2
MIRT681266 RFC2 replication factor C subunit 2 2 2
MIRT681318 ZFAND4 zinc finger AN1-type containing 4 2 4
MIRT681354 BRI3BP BRI3 binding protein 2 2
MIRT681501 STAT2 signal transducer and activator of transcription 2 2 2
MIRT681531 ZNF738 zinc finger protein 738 2 2
MIRT681653 DTX3L deltex E3 ubiquitin ligase 3L 2 2
MIRT681733 RAB19 RAB19, member RAS oncogene family 2 4
MIRT681756 CDKAL1 CDK5 regulatory subunit associated protein 1 like 1 2 2
MIRT681792 EIF4A3 eukaryotic translation initiation factor 4A3 2 2
MIRT681864 DNAH9 dynein axonemal heavy chain 9 2 2
MIRT681936 SLC19A3 solute carrier family 19 member 3 2 2
MIRT682097 ITGA3 integrin subunit alpha 3 2 4
MIRT682177 SLC38A7 solute carrier family 38 member 7 2 2
MIRT682233 SAR1A secretion associated Ras related GTPase 1A 2 2
MIRT682379 PHACTR4 phosphatase and actin regulator 4 2 2
MIRT682439 MTX3 metaxin 3 2 2
MIRT682599 CPA4 carboxypeptidase A4 2 2
MIRT682635 COX6B1 cytochrome c oxidase subunit 6B1 2 2
MIRT689323 FPR1 formyl peptide receptor 1 2 2
MIRT689725 ATXN2 ataxin 2 2 2
MIRT691031 ZNF799 zinc finger protein 799 2 2
MIRT691930 DNAJC28 DnaJ heat shock protein family (Hsp40) member C28 2 2
MIRT694879 ZNF417 zinc finger protein 417 2 2
MIRT695250 ZNF443 zinc finger protein 443 2 2
MIRT695408 ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide 2 2
MIRT700593 PRSS22 protease, serine 22 2 2
MIRT701434 NHLRC2 NHL repeat containing 2 2 2
MIRT702479 KIAA1328 KIAA1328 2 2
MIRT702716 IPO9 importin 9 2 2
MIRT704036 EDEM3 ER degradation enhancing alpha-mannosidase like protein 3 2 2
MIRT704415 CTPS1 CTP synthase 1 2 2
MIRT705745 AMD1 adenosylmethionine decarboxylase 1 2 2
MIRT712369 NAP1L1 nucleosome assembly protein 1 like 1 2 2
MIRT713515 PAFAH2 platelet activating factor acetylhydrolase 2 2 2
MIRT735773 STAT3 signal transducer and activator of transcription 3 6 1
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-4 Dexamethasone approved 5743 Microarray primary rat thymocytes 20847043 2010 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-4500 Osimertinib 71496458 NSC779217 approved sensitive cell line (H1975)

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