miRTarBase - #MIRT085323


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pre-miRNA Information
pre-miRNA hsa-mir-758   
Genomic Coordinates chr14: 101026020 - 101026107
Synonyms MIRN758, hsa-mir-758, MIR758
Description Homo sapiens miR-758 stem-loop
Comment None
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-758-5p
Sequence 15| GAUGGUUGACCAGAGAGCACAC |36
Evidence Experimental
Experiments SOLiD
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 16 14 + 101026049 29233923 MiREDiBase
A-to-I 21 14 + 101026054 29233923 MiREDiBase
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs372417522 1 dbSNP
rs748092616 2 dbSNP
rs1270901332 4 dbSNP
rs1364206491 5 dbSNP
rs1483583954 8 dbSNP
rs770931807 10 dbSNP
rs776760808 11 dbSNP
rs1360350664 12 dbSNP
rs759742151 13 dbSNP
rs1002938972 15 dbSNP
rs770107042 17 dbSNP
rs369242818 20 dbSNP
rs1217090272 21 dbSNP
rs763341052 22 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol MORC3   
Synonyms NXP2, ZCW5, ZCWCC3
Description MORC family CW-type zinc finger 3
Transcript NM_015358   
Expression
Putative miRNA Targets on MORC3
3'UTR of MORC3
(miRNA target sites are highlighted)		 
>MORC3|NM_015358|3'UTR
   1 AGTATATGTTATGTAAGATAAAATATTTGCTCAATTCTTTTGGTTGTACAGCTTTCAAAATATAATTAATTTTGTTTTAT
  81 AGATATGATAGGCAACAGACTGAAAACCATAATCTTTACTGTATTCTATGCATTCAAATGTGGTCACAAATATTGTGGAC
 161 ACATTATCTTATGTTTTGAAATACCTGTGAATTGTTGGCATTGAGCAGCTGAAGCTAACTCATGACTCTGTTTTGAATGT
 241 AAATATTTGTAATTAAGCCTGCACATATTTTTTTATTGCCCTAGAGTACTCAAGTGTTTTTCACCAAGAGCTTTTCAGGT
 321 TGCCCCTAAGCTTTGTGCAATTTTTTCTGGTTCCCCAAAGTGTATTTTTCTCTAAGTCGAGGGCTATGCCATAATACAAA
 401 TGGAAATGTTACCTTTGATTTTCTTATAAAGGAGTTTAAATAGGATTTTTAAATAATGTAGTAACACTCCTGATACAACT
 481 CTGGTTATAAGTGAATTGAGCATTAATGTTTCTTTTGTATAAATTCCTGTCCTGAAATATTTTATTCATGAAAATAAGGT
 561 AAGCAAAAACCAACTCCATTTTGCCAGGATTTTGTTGTGCTGAGATTGCCAATCACGGTTAAACACAAAGTGTTTTTATA
 641 GAATGAAGAAACAGTCTTTAACAGAAAAAAGGTATTGAAATATTAAATGGCCACCAAGTTTACTTTGAAGCCCATTTTTG
 721 GCTGTTTAGTCAGCATGAAGTGGGCATGATAATTTTTTAATATTTCTTTTTGTGAAATTTCCTGTACAGCCTTTTGTAGG
 801 ATTACTACAGGTTAATGTGAGTTGAGGAAGACAGTCTTTCTCAAACAATACTACATACCTTTTATTATATTACAAACCTA
 881 AGTGTTTTATATCCTAGAGTCAAGGAACAAATTTCCTTAGGATTATAGTATTACATGCCATAAAATACTATGCTTTATTG
 961 GTCCCATGTTTTGTGCAATTTTAAAGAGATGGCTTTCTATTAAGTATAAACTATGTATATATAAGAACCATATTTTCCAC
1041 AACTAAAATGTGCATTATTTTTTCCAAAGTTTTATCATTGCTATTTATTTTTACCTTTGTTTTTGAACATTCAATCCGTT
1121 CATTTTGTATGTATGCTTAATACGTGTCGGTCATATACAGTATTGAATTTTTACTGTATAGTAATTCTGGAAAGAGCAAA
1201 TAAATGAAGATTGTTTTTATTTGCCTGATAAAGTAATTGAAAGTGTATTTTTGGTATGAAGCTGGTTTTCTGTCACAATT
1281 GTAATTTCCCAAATTTTAAAATATCTTATAATAAAATAAAAATATATGATGGCTAACTGTTCAAATGCTA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' cacacgagagaccagUUGGUAg 5'
                         |||||| 
Target 5' aggcaacagactgaaAACCATa 3'
 90 - 111 120.00 -9.10
2 
miRNA  3' caCACGA-GAGACCAGUUGGUag 5'
            |||||    | | |||:||  
Target 5' ttGTGCTGAGATTGCCAATCAcg 3'
 595 - 617 116.00 -10.60
3 
miRNA  3' cacaCGAGAGACCA--GUUGGUAg 5'
              |:|:||| ||  |||:::| 
Target 5' gctgGTTTTCT-GTCACAATTGTa 3'
 1261 - 1283 111.00 -12.09
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30494113 30 COSMIC
COSN31559953 31 COSMIC
COSN13882838 38 COSMIC
COSN30191377 63 COSMIC
COSN19121910 79 COSMIC
COSN30160017 103 COSMIC
COSN30175936 169 COSMIC
COSN31591648 184 COSMIC
COSN31609678 273 COSMIC
COSN26277328 405 COSMIC
COSN29100367 755 COSMIC
COSN30166716 927 COSMIC
COSN31547777 939 COSMIC
COSN1891936 1048 COSMIC
COSN5986274 1185 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1324873018 3 dbSNP
rs767204152 5 dbSNP
rs1226999993 6 dbSNP
rs1327535399 7 dbSNP
rs774978754 13 dbSNP
rs1063308 14 dbSNP
rs763611356 16 dbSNP
rs373001534 19 dbSNP
rs1231892619 20 dbSNP
rs766718623 23 dbSNP
rs751919262 24 dbSNP
rs1190344471 25 dbSNP
rs1489718908 27 dbSNP
rs992337265 29 dbSNP
rs1194587881 32 dbSNP
rs1251119700 33 dbSNP
rs755198660 36 dbSNP
rs1184586738 38 dbSNP
rs78289545 41 dbSNP
rs1207262885 48 dbSNP
rs752809855 50 dbSNP
rs1301056667 63 dbSNP
rs1258062942 77 dbSNP
rs144873225 82 dbSNP
rs1040518792 87 dbSNP
rs1407606142 88 dbSNP
rs1186828382 90 dbSNP
rs1308051081 101 dbSNP
rs902012265 102 dbSNP
rs546963169 110 dbSNP
rs1357316780 112 dbSNP
rs1026489481 120 dbSNP
rs369658034 129 dbSNP
rs1431151016 132 dbSNP
rs1006491068 136 dbSNP
rs1472353051 139 dbSNP
rs1252630737 140 dbSNP
rs977477419 148 dbSNP
rs924269957 149 dbSNP
rs1255969271 154 dbSNP
rs1211398491 162 dbSNP
rs969724050 168 dbSNP
rs981147835 173 dbSNP
rs1266615840 181 dbSNP
rs186653355 191 dbSNP
rs1226206989 196 dbSNP
rs1349425516 201 dbSNP
rs1035363894 222 dbSNP
rs955797624 223 dbSNP
rs1376317769 226 dbSNP
rs989023633 230 dbSNP
rs935685290 232 dbSNP
rs914431056 239 dbSNP
rs1304786317 240 dbSNP
rs1054093342 243 dbSNP
rs571143407 246 dbSNP
rs1412909557 254 dbSNP
rs190820022 265 dbSNP
rs1422172618 268 dbSNP
rs1308345806 270 dbSNP
rs888872772 280 dbSNP
rs985424997 287 dbSNP
rs943197404 291 dbSNP
rs549229143 294 dbSNP
rs1463004617 297 dbSNP
rs747075155 310 dbSNP
rs910550874 326 dbSNP
rs943391781 332 dbSNP
rs182059789 336 dbSNP
rs1240705588 338 dbSNP
rs1319461324 341 dbSNP
rs186296638 341 dbSNP
rs1040246072 350 dbSNP
rs901740002 351 dbSNP
rs1384852326 354 dbSNP
rs901891409 358 dbSNP
rs1434152982 361 dbSNP
rs1389058995 364 dbSNP
rs1295249328 366 dbSNP
rs993459210 371 dbSNP
rs1026663206 373 dbSNP
rs16994052 379 dbSNP
rs1006230825 380 dbSNP
rs1165494150 384 dbSNP
rs1033732430 393 dbSNP
rs1482153597 395 dbSNP
rs1188462421 403 dbSNP
rs1199605019 410 dbSNP
rs1465663771 413 dbSNP
rs959478659 428 dbSNP
rs1206540675 433 dbSNP
rs1487261723 447 dbSNP
rs1264382372 454 dbSNP
rs189850219 459 dbSNP
rs992325839 466 dbSNP
rs116006149 470 dbSNP
rs1295363084 472 dbSNP
rs111450902 473 dbSNP
rs1227564186 477 dbSNP
rs180753969 484 dbSNP
rs1319979142 497 dbSNP
rs1385317517 507 dbSNP
rs1179883482 514 dbSNP
rs1294220925 519 dbSNP
rs1426681373 534 dbSNP
rs967291785 538 dbSNP
rs527706373 540 dbSNP
rs1450575557 542 dbSNP
rs925527666 543 dbSNP
rs759312928 544 dbSNP
rs1431115526 545 dbSNP
rs1235959307 546 dbSNP
rs905533435 550 dbSNP
rs1002460525 560 dbSNP
rs185756612 572 dbSNP
rs955960119 579 dbSNP
rs1465868945 587 dbSNP
rs935634669 593 dbSNP
rs1308965857 599 dbSNP
rs988602617 602 dbSNP
rs1372983695 610 dbSNP
rs80088522 617 dbSNP
rs1307940243 618 dbSNP
rs1349407314 627 dbSNP
rs910299380 631 dbSNP
rs1330279051 647 dbSNP
rs1284213832 652 dbSNP
rs1406991219 654 dbSNP
rs191124898 657 dbSNP
rs968616427 660 dbSNP
rs575437761 673 dbSNP
rs1465887933 675 dbSNP
rs943145204 692 dbSNP
rs1378566402 699 dbSNP
rs1199766114 701 dbSNP
rs369007667 702 dbSNP
rs1248994719 703 dbSNP
rs770122231 705 dbSNP
rs1438350652 711 dbSNP
rs1275093267 722 dbSNP
rs1198632528 728 dbSNP
rs911105444 731 dbSNP
rs1310023389 735 dbSNP
rs943941359 736 dbSNP
rs1232296437 739 dbSNP
rs1348814541 741 dbSNP
rs868575252 749 dbSNP
rs901649483 763 dbSNP
rs1443083035 787 dbSNP
rs1337576006 800 dbSNP
rs1275135084 807 dbSNP
rs1332842913 808 dbSNP
rs1414384926 810 dbSNP
rs1407311452 813 dbSNP
rs138313100 821 dbSNP
rs544416680 831 dbSNP
rs923284693 839 dbSNP
rs1470772221 840 dbSNP
rs929150499 849 dbSNP
rs372652079 850 dbSNP
rs1203005673 852 dbSNP
rs1409254735 852 dbSNP
rs1047601687 854 dbSNP
rs1234112932 856 dbSNP
rs35658312 860 dbSNP
rs1185404668 867 dbSNP
rs887703966 876 dbSNP
rs1441714781 885 dbSNP
rs929363281 888 dbSNP
rs1006220932 894 dbSNP
rs1250982062 900 dbSNP
rs1047835689 906 dbSNP
rs1267781609 910 dbSNP
rs1192934275 911 dbSNP
rs1353002152 913 dbSNP
rs1033721018 916 dbSNP
rs1432782714 921 dbSNP
rs909363589 937 dbSNP
rs552253023 939 dbSNP
rs868485844 940 dbSNP
rs1339134074 942 dbSNP
rs564457321 951 dbSNP
rs966862346 952 dbSNP
rs1350911427 958 dbSNP
rs978672519 960 dbSNP
rs1294730716 972 dbSNP
rs531870127 979 dbSNP
rs1439768252 980 dbSNP
rs958321217 985 dbSNP
rs1160908679 987 dbSNP
rs989755762 990 dbSNP
rs910246892 993 dbSNP
rs891491450 997 dbSNP
rs1185311695 1002 dbSNP
rs1463428051 1005 dbSNP
rs1247167173 1014 dbSNP
rs183786695 1018 dbSNP
rs2633325 1022 dbSNP
rs1448885675 1037 dbSNP
rs975832924 1043 dbSNP
rs923016292 1068 dbSNP
rs1227766851 1070 dbSNP
rs929122277 1078 dbSNP
rs1317829478 1087 dbSNP
rs1048058742 1105 dbSNP
rs909127794 1110 dbSNP
rs941951680 1118 dbSNP
rs577966663 1119 dbSNP
rs1346548395 1122 dbSNP
rs540159491 1123 dbSNP
rs1223908424 1124 dbSNP
rs1321151263 1131 dbSNP
rs1423494441 1134 dbSNP
rs550295370 1144 dbSNP
rs1014005192 1145 dbSNP
rs1006692470 1149 dbSNP
rs1186852536 1150 dbSNP
rs1488187013 1151 dbSNP
rs1245252489 1156 dbSNP
rs9108 1159 dbSNP
rs965264077 1164 dbSNP
rs1294027375 1176 dbSNP
rs902630218 1179 dbSNP
rs1341990839 1181 dbSNP
rs1188267417 1182 dbSNP
rs999695792 1183 dbSNP
rs1365888005 1185 dbSNP
rs1032496372 1187 dbSNP
rs1407611089 1190 dbSNP
rs1163264643 1193 dbSNP
rs568711627 1204 dbSNP
rs1427771704 1221 dbSNP
rs958269413 1241 dbSNP
rs1024917008 1259 dbSNP
rs1018500026 1280 dbSNP
rs964308716 1292 dbSNP
rs976162351 1295 dbSNP
rs1460462305 1297 dbSNP
rs1422798163 1301 dbSNP
rs1320814685 1305 dbSNP
rs1366847091 1307 dbSNP
rs1432661871 1310 dbSNP
rs923038779 1314 dbSNP
rs529284735 1325 dbSNP
rs1180056615 1326 dbSNP
rs1379587185 1327 dbSNP
rs1230009953 1331 dbSNP
rs942122304 1332 dbSNP
rs549394725 1334 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Disease 23515.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM714644. RNA binding protein: AGO2. Condition:completeT1 ...

- Kishore S; Jaskiewicz L; Burger L; Hausser et al., 2011, Nature methods.

Article - Kishore S; Jaskiewicz L; Burger L; Hausser et al.
- Nature methods, 2011
Cross-linking and immunoprecipitation (CLIP) is increasingly used to map transcriptome-wide binding sites of RNA-binding proteins. We developed a method for CLIP data analysis, and applied it to compare CLIP with photoactivatable ribonucleoside-enhanced CLIP (PAR-CLIP) and to uncover how differences in cross-linking and ribonuclease digestion affect the identified sites. We found only small differences in accuracies of these methods in identifying binding sites of HuR, which binds low-complexity sequences, and Argonaute 2, which has a complex binding specificity. We found that cross-link-induced mutations led to single-nucleotide resolution for both PAR-CLIP and CLIP. Our results confirm the expectation from original CLIP publications that RNA-binding proteins do not protect their binding sites sufficiently under the denaturing conditions used during the CLIP procedure, and we show that extensive digestion with sequence-specific RNases strongly biases the recovered binding sites. This bias can be substantially reduced by milder nuclease digestion conditions.
LinkOut: [PMID: 21572407]
CLIP-seq Support 1 for dataset GSM714644
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / completeT1, repA
Location of target site ENST00000400485.1 | 3UTR | AAAACCAUAAUCUUUACUGUAUUCUAUGC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 21572407 / GSE28865
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
62 hsa-miR-758-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT085323 MORC3 MORC family CW-type zinc finger 3 2 2
MIRT089441 STAMBP STAM binding protein 2 2
MIRT089456 TET3 tet methylcytosine dioxygenase 3 2 2
MIRT111856 CCND1 cyclin D1 2 2
MIRT184933 ZNF268 zinc finger protein 268 2 2
MIRT215288 CREBRF CREB3 regulatory factor 2 2
MIRT237300 LPP LIM domain containing preferred translocation partner in lipoma 2 2
MIRT238446 MYO10 myosin X 2 4
MIRT273827 RPL41 ribosomal protein L41 2 2
MIRT282703 HOOK1 hook microtubule tethering protein 1 2 2
MIRT347970 ZNF850 zinc finger protein 850 2 2
MIRT371076 KLF3 Kruppel like factor 3 2 2
MIRT464339 USP6NL USP6 N-terminal like 2 2
MIRT470034 PTP4A1 protein tyrosine phosphatase type IVA, member 1 2 2
MIRT477506 ELL2 elongation factor for RNA polymerase II 2 2 2
MIRT482886 CACNA2D3 calcium voltage-gated channel auxiliary subunit alpha2delta 3 2 2
MIRT492606 POLR3E RNA polymerase III subunit E 2 2
MIRT502294 GNG12 G protein subunit gamma 12 2 6
MIRT507600 DCTN4 dynactin subunit 4 2 4
MIRT510728 SON SON DNA binding protein 2 6
MIRT514065 KCNJ6 potassium voltage-gated channel subfamily J member 6 2 8
MIRT519718 ZNF512B zinc finger protein 512B 2 4
MIRT520890 STRN striatin 2 2
MIRT521760 PPIL1 peptidylprolyl isomerase like 1 2 6
MIRT526874 ERCC8 ERCC excision repair 8, CSA ubiquitin ligase complex subunit 2 2
MIRT530232 WSB2 WD repeat and SOCS box containing 2 2 2
MIRT532003 ACTR2 ARP2 actin related protein 2 homolog 2 2
MIRT533371 UBE2D4 ubiquitin conjugating enzyme E2 D4 (putative) 2 4
MIRT547106 PIGW phosphatidylinositol glycan anchor biosynthesis class W 2 2
MIRT548189 FOXA1 forkhead box A1 2 2
MIRT552935 VKORC1L1 vitamin K epoxide reductase complex subunit 1 like 1 2 2
MIRT560085 ZNF195 zinc finger protein 195 2 2
MIRT561726 PPP2CA protein phosphatase 2 catalytic subunit alpha 2 2
MIRT562713 ZNF415 zinc finger protein 415 2 2
MIRT562761 ZNF846 zinc finger protein 846 2 2
MIRT564159 ZNF117 zinc finger protein 117 2 2
MIRT565673 SETD5 SET domain containing 5 2 2
MIRT565718 SESN3 sestrin 3 2 2
MIRT566026 RFX1 regulatory factor X1 2 2
MIRT569048 ZNF655 zinc finger protein 655 2 2
MIRT570367 UBE2V1 ubiquitin conjugating enzyme E2 V1 2 2
MIRT570410 TMEM189-UBE2V1 TMEM189-UBE2V1 readthrough 2 2
MIRT570443 TMEM189 transmembrane protein 189 2 2
MIRT571738 RNF11 ring finger protein 11 2 2
MIRT575042 Tpgs2 tubulin polyglutamylase complex subunit 2 2 4
MIRT614330 ZDHHC22 zinc finger DHHC-type containing 22 2 2
MIRT617629 RAB3IP RAB3A interacting protein 2 2
MIRT621667 UBE4B ubiquitination factor E4B 2 2
MIRT639906 SRGAP2 SLIT-ROBO Rho GTPase activating protein 2 2 2
MIRT651436 XRCC5 X-ray repair cross complementing 5 2 2
MIRT683853 ZNF208 zinc finger protein 208 2 2
MIRT684841 TPGS2 tubulin polyglutamylase complex subunit 2 2 5
MIRT689347 ZNF83 zinc finger protein 83 2 2
MIRT692492 SPIN4 spindlin family member 4 2 2
MIRT695711 OLA1 Obg like ATPase 1 2 2
MIRT698219 TMEM248 transmembrane protein 248 2 2
MIRT711560 FAM20B FAM20B, glycosaminoglycan xylosylkinase 2 2
MIRT712867 TMEM67 transmembrane protein 67 2 2
MIRT722956 TSPAN1 tetraspanin 1 2 2
MIRT723622 SOBP sine oculis binding protein homolog 2 2
MIRT724176 ABCF2 ATP binding cassette subfamily F member 2 2 2
MIRT755363 LMBR1 limb development membrane protein 1 3 1
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-758 Hydroxycamptothecin (HCPT) NULL 97226 Microarray human Tenon's fibroblasts (HTFs) 24681041 2014 down-regulated
miR-758 Diethylstilbestrol approved 448537 Microarray mammosphere-derived epithelial cells (MDEC) 19549897 2009 up-regulated
miR-758 5-Fluorouracil approved 3385 Quantitative real-time PCR human squamous cell carcinoma cell line KYSE410 21743970 2011 up-regulated
miR-758 Reversine NULL 210332 Microarray C2C12 myoblast cells 24513286 2014 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-758 Ceritinib 57379345 NSC776422 approved resistant High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-mir-758 Fluorouracil 3385 NSC19893 approved resistant cell line (KYSE)
hsa-mir-758 Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)
hsa-miR-758-5p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-758-5p Osimertinib 71496458 NSC779217 approved sensitive cell line (HCC827)
hsa-miR-758-5p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-758-5p Paclitaxel 36314 NSC125973 approved sensitive cell line (BAS)
hsa-miR-758-5p Doxorubicin 31703 NSC123127 approved sensitive cell line (BAS)
hsa-miR-758-5p Osimertinib 71496458 NSC779217 approved resistant cell line (H1975)
hsa-miR-758-5p Gemcitabine 60750 NSC613327 approved resistant cell line (PANC-1) (1500 ng/ml)
hsa-miR-758-5p Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)

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