miRTarBase - #MIRT085407


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pre-miRNA Information
pre-miRNA hsa-mir-548ap   
Genomic Coordinates chr15: 85825635 - 85825730
Description Homo sapiens miR-548ap stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-548ap-3p
Sequence 58| AAAAACCACAAUUACUUUU |76
Evidence Not_experimental
Experiments
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 8 15 + 85825699 29233923 MiREDiBase
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1391959840 4 dbSNP
rs1164149363 6 dbSNP
rs150751643 7 dbSNP
rs1414633461 15 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol ETS2   
Synonyms ETS2IT1
Description ETS proto-oncogene 2, transcription factor
Transcript NM_005239   
Expression
Putative miRNA Targets on ETS2
3'UTR of ETS2
(miRNA target sites are highlighted)		 
>ETS2|NM_005239|3'UTR
   1 GGTCGCCGGGACCACCCTGAGCCGGCCCCAGGCTCGTGGACTGAGTGGGAAGCCCATCCTGACCAGCTGCTCCGAGGACC
  81 CAGGAAAGGCAGGATTGAAAATGTCCAGGAAAGTGGCCAAGAAGCAGTGGCCTTATTGCATCCCAAACCACGCCTCTTGA
 161 CCAGGCTGCCTCCCTTGTGGCAGCAACGGCACAGCTAATTCTACTCACAGTGCTTTTAAGTGAAAATGGTCGAGAAAGAG
 241 GCACCAGGAAGCCGTCCTGGCGCCTGGCAGTCCGTGGGACGGGATGGTTCTGGCTGTTTGAGATTCTCAAAGGAGCGAGC
 321 ATGTCGTGGACACACACAGACTATTTTTAGATTTTCTTTTGCCTTTTGCAACCAGGAACAGCAAATGCAAAAACTCTTTG
 401 AGAGGGTAGGAGGGTGGGAAGGAAACAACCATGTCATTTCAGAAGTTAGTTTGTATATATTATTATAATCTTATAATTGT
 481 TCTCAGAATCCCTTAACAGTTGTATTTAACAGAAATTGTATATTGTAATTTAAAATAATTATATAACTGTATTTGAAATA
 561 AGAATTCAGACATCTGAGGTTTTATTTCATTTTTCAATAGCACATATGGAATTTTGCAAAGATTTAATCTGCCAAGGGCC
 641 GACTAAGAGAAGTTGTAAAGTATGTATTATTTACATTTAATAGACTTACAGGGATAAGGCCTGTGGGGGGTAATCCCTGC
 721 TTTTTGTGTTTTTTTGTTTGTTTGTTTGTTTGTTTTTGGGGGGTTTTCTTGCCTTGGTTGTCTGGCAAGGACTTTGTACA
 801 TTTGGGAGTTTTTATGAGAAACTTAAATGTTATTATCTGGGCTTATATCTGGCCTCTGCTTTCTCCTTTAATTGTAAAGT
 881 AAAAGCTATAAAGCAGTATTTTTCTTGACAAATGGCATATGTTTTCCACTTCTTTGCATGCGTTTAAGTCAGTTTATACA
 961 CAAAATGGATTTTATTTTTTAGTTTAACTGTGTTTCTCCGACAGCTCACCTCTCTCTGACCACCCAGCCATTTCCTTCCT
1041 GTGCTCCACGTTCTTCTGTGTGATTAAAATAAGAATATTATTTTTGGAAATATGCAACTCCTTTTCAGAGATCAGGAGGG
1121 ATTTATGTAGCAGCTATTTTTACTGCAAAAGTAATTCACTGGAAAAAAAATGTAATTTGTAAGAAAGCTTTATTTTTATC
1201 TCAGCTCTATGTAAAGTTAAAGTTACTGTACAGAGCTGAAGGACGGGGGGCGGTAGGGGTCTTGATGAAACCTCTTGAAC
1281 GAAGCACAGTTTGTCCCATCTTTGTTCACTCGTGTGTCTCAACCATCTTAATAGCATGCTGCTCCTTTTTGCTCAGTGTC
1361 CACAGCAAGATGACGTGATTCTTATTTTCTTGGACACAGACTATTCTGAGGCACAGAGCGGGGACTTAAGATGGGAAAGA
1441 GAAAGCATCGGAGCCATTCATTCGGAGAAAACGTTTTGATCAAAATGGAGACTTTTGTAGTCGTTTCAAAAGAGCACCTG
1521 AGTCATGTGTATTCCCGGCCTTTATAAATGACCCGGTCAAGTTGGTTTCAAAGTCCGACAGGCTTGTCTGTTTACTAGCT
1601 GCGTGGCCTTGGACGGGTGGCTGACATCTGTAAAGAATCCTCCTGTGATGAAACTGAGGAATCGGGTGGCCGGGCAAGCT
1681 GGGAAGAGCAAAGCCAGAGCTGCGCTGCCTCAATACCCACAAAAGACCATTCCCAGTATACATAAGCACAGGATGTTTTT
1761 CTCAAGAGGGATGTATTTATCACTTGGACATCTGTTTATAATATAAACAGACATGTGACTGGGAACATCTTGCTGCCAAA
1841 AGAATCCTAGGCAGTGGCTCATTGTATGTGAGGTTGAACCACGTGAAATTGCCAATATTAGGCTGGCTTTTATCTACAAA
1921 GAAGGAGTTTCATGGGGTTCAGCCTAACAGTTATGGAAACTACAGTCCTTATAAACCATTGGCATGGTAATAAACAGATC
2001 TTAAGTATAAAAATTTTGTAATTGGGCCTTTACTCTCTCAATAATAAAGTATTTTGTTTATATAAAAAAAAAAAAAAAAA
2081 AAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' uuuUCAUUA-ACACCAAAAa 5'
             ||  || || |||||| 
Target 5' ttcAGACATCTGAGGTTTTa 3'
 565 - 584 124.00 -5.50
2 
miRNA  3' uuuucauuaacaCCAAAAa 5'
                      |||||| 
Target 5' ttgtttttggggGGTTTTc 3'
 750 - 768 120.00 -6.80
3 
miRNA  3' uuuucauuaacACCAAAAa 5'
                     ||||| | 
Target 5' gtgggacgggaTGGTTCTg 3'
 274 - 292 108.00 -5.54
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30143023 13 COSMIC
COSN13883637 36 COSMIC
COSN30100611 53 COSMIC
COSN21633139 178 COSMIC
COSN19662376 247 COSMIC
COSN31489875 309 COSMIC
COSN31544646 435 COSMIC
COSN9158611 458 COSMIC
COSN31520372 547 COSMIC
COSN31530538 678 COSMIC
COSN20116917 736 COSMIC
COSN20116920 753 COSMIC
COSN26576850 763 COSMIC
COSN26555526 785 COSMIC
COSN5136317 796 COSMIC
COSN4783778 807 COSMIC
COSN22868990 1171 COSMIC
COSN26507767 1174 COSMIC
COSN26565884 1242 COSMIC
COSN30540248 1245 COSMIC
COSN28201312 1259 COSMIC
COSN17539868 1431 COSMIC
COSN20116921 1543 COSMIC
COSN30540103 1738 COSMIC
COSN21754898 1788 COSMIC
COSN26504542 1822 COSMIC
COSN26554971 1943 COSMIC
COSN31540608 2049 COSMIC
rs11422952 730 GWAS
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs748411569 3 dbSNP
rs1012179576 5 dbSNP
rs756327386 8 dbSNP
rs368810027 9 dbSNP
rs1221089669 13 dbSNP
rs749321433 14 dbSNP
rs1175755742 15 dbSNP
rs1430254787 17 dbSNP
rs1471046923 18 dbSNP
rs541032626 24 dbSNP
rs745774816 25 dbSNP
rs1431450255 26 dbSNP
rs368226367 29 dbSNP
rs1431775687 30 dbSNP
rs766332190 36 dbSNP
rs760464569 37 dbSNP
rs776012464 42 dbSNP
rs761351035 43 dbSNP
rs1226187297 44 dbSNP
rs1282647630 51 dbSNP
rs1301474762 61 dbSNP
rs923591465 66 dbSNP
rs559989919 73 dbSNP
rs751390870 74 dbSNP
rs1021702154 75 dbSNP
rs573870357 77 dbSNP
rs1418841124 78 dbSNP
rs1315073624 83 dbSNP
rs902972387 84 dbSNP
rs989634862 85 dbSNP
rs77488352 92 dbSNP
rs947516194 95 dbSNP
rs960212943 112 dbSNP
rs974982847 115 dbSNP
rs75261542 141 dbSNP
rs933560935 150 dbSNP
rs1244007915 152 dbSNP
rs953066414 155 dbSNP
rs1209096674 159 dbSNP
rs759548162 162 dbSNP
rs1462792671 168 dbSNP
rs1310890323 174 dbSNP
rs149232522 180 dbSNP
rs1214598722 188 dbSNP
rs767662478 189 dbSNP
rs1275877791 193 dbSNP
rs1237856771 198 dbSNP
rs886436632 201 dbSNP
rs1445733753 203 dbSNP
rs1358462277 204 dbSNP
rs188181785 205 dbSNP
rs1409281082 206 dbSNP
rs933180295 209 dbSNP
rs1477587331 230 dbSNP
rs1174345060 232 dbSNP
rs1038158020 237 dbSNP
rs756381113 239 dbSNP
rs1258659508 242 dbSNP
rs1190465290 243 dbSNP
rs899001356 244 dbSNP
rs711 247 dbSNP
rs1023571475 250 dbSNP
rs1255824249 254 dbSNP
rs1042940953 261 dbSNP
rs551147066 262 dbSNP
rs564973656 263 dbSNP
rs1226349425 268 dbSNP
rs1399183479 274 dbSNP
rs1443922543 275 dbSNP
rs998497627 277 dbSNP
rs368795899 281 dbSNP
rs1443099434 300 dbSNP
rs1030708279 317 dbSNP
rs1402570101 318 dbSNP
rs1329325335 320 dbSNP
rs1465330893 321 dbSNP
rs956568384 325 dbSNP
rs1167413175 326 dbSNP
rs757620063 327 dbSNP
rs1413786954 336 dbSNP
rs1373888344 340 dbSNP
rs1178265757 341 dbSNP
rs1442024623 345 dbSNP
rs200475079 349 dbSNP
rs1235830567 357 dbSNP
rs1197408976 360 dbSNP
rs1218608709 364 dbSNP
rs1298858245 383 dbSNP
rs1022437538 387 dbSNP
rs1219193667 388 dbSNP
rs779341248 405 dbSNP
rs141493936 411 dbSNP
rs922084681 414 dbSNP
rs560721778 419 dbSNP
rs775564273 430 dbSNP
rs1013122915 431 dbSNP
rs1446104925 441 dbSNP
rs988120404 454 dbSNP
rs907878253 458 dbSNP
rs1456763249 465 dbSNP
rs530 465 dbSNP
rs1349677864 470 dbSNP
rs8133034 471 dbSNP
rs1442116234 476 dbSNP
rs71316657 481 dbSNP
rs899220185 511 dbSNP
rs1177516593 512 dbSNP
rs1454306904 526 dbSNP
rs147035130 531 dbSNP
rs1488410239 533 dbSNP
rs1189957453 534 dbSNP
rs1189114581 537 dbSNP
rs571239774 548 dbSNP
rs41276544 554 dbSNP
rs1217618339 559 dbSNP
rs1351484692 572 dbSNP
rs1285182775 585 dbSNP
rs1044944028 586 dbSNP
rs961379173 598 dbSNP
rs906364386 599 dbSNP
rs976704835 601 dbSNP
rs1003498697 603 dbSNP
rs1357040226 604 dbSNP
rs1289837799 605 dbSNP
rs922721171 608 dbSNP
rs1422401632 615 dbSNP
rs570141612 618 dbSNP
rs1359226755 639 dbSNP
rs539232105 641 dbSNP
rs191832014 642 dbSNP
rs1051420 652 dbSNP
rs1432259034 653 dbSNP
rs769486737 654 dbSNP
rs1195631510 656 dbSNP
rs1487184939 661 dbSNP
rs534668750 665 dbSNP
rs1051425 673 dbSNP
rs1301184863 681 dbSNP
rs1257866907 682 dbSNP
rs574806114 693 dbSNP
rs1231093574 703 dbSNP
rs934343681 705 dbSNP
rs1056809843 707 dbSNP
rs1402315518 708 dbSNP
rs1338921175 709 dbSNP
rs1347380091 710 dbSNP
rs140874343 714 dbSNP
rs201404243 721 dbSNP
rs11422952 729 dbSNP
rs397828592 729 dbSNP
rs746930778 729 dbSNP
rs776048795 729 dbSNP
rs563400088 730 dbSNP
rs1012672465 733 dbSNP
rs527990345 733 dbSNP
rs1005696479 734 dbSNP
rs1016285075 737 dbSNP
rs961595984 739 dbSNP
rs998177620 749 dbSNP
rs1029616461 758 dbSNP
rs1321161874 758 dbSNP
rs1219551082 764 dbSNP
rs1271668562 769 dbSNP
rs1277993690 772 dbSNP
rs954007465 777 dbSNP
rs985956912 787 dbSNP
rs1029151207 790 dbSNP
rs1332767896 791 dbSNP
rs184055024 807 dbSNP
rs1396607626 808 dbSNP
rs1332715010 812 dbSNP
rs1463762718 827 dbSNP
rs13046062 837 dbSNP
rs1399032296 842 dbSNP
rs1165436483 843 dbSNP
rs954841704 851 dbSNP
rs978604195 859 dbSNP
rs1186732587 860 dbSNP
rs3178021 864 dbSNP
rs3178022 866 dbSNP
rs3178023 867 dbSNP
rs934560040 870 dbSNP
rs770560670 874 dbSNP
rs1057030857 875 dbSNP
rs908096926 897 dbSNP
rs1216189033 904 dbSNP
rs11540812 911 dbSNP
rs1358894959 912 dbSNP
rs1169263722 914 dbSNP
rs1282730681 916 dbSNP
rs1244704110 920 dbSNP
rs962084419 921 dbSNP
rs916925620 930 dbSNP
rs973841778 931 dbSNP
rs868028194 939 dbSNP
rs1367296793 942 dbSNP
rs150174386 943 dbSNP
rs188051027 948 dbSNP
rs1297301067 949 dbSNP
rs564938237 957 dbSNP
rs948160013 963 dbSNP
rs1324441601 968 dbSNP
rs1162395312 969 dbSNP
rs1045167818 975 dbSNP
rs1382076164 984 dbSNP
rs1432681403 989 dbSNP
rs114957306 991 dbSNP
rs939155768 999 dbSNP
rs374994045 1000 dbSNP
rs567542163 1001 dbSNP
rs897451604 1002 dbSNP
rs1010804171 1010 dbSNP
rs998396695 1011 dbSNP
rs1355102276 1012 dbSNP
rs1051475 1016 dbSNP
rs1051476 1024 dbSNP
rs996559328 1026 dbSNP
rs550167564 1033 dbSNP
rs1022829690 1038 dbSNP
rs1322708195 1045 dbSNP
rs954919916 1051 dbSNP
rs1362459736 1064 dbSNP
rs1156762585 1068 dbSNP
rs571831801 1081 dbSNP
rs968152353 1082 dbSNP
rs1173189993 1096 dbSNP
rs1479139977 1103 dbSNP
rs570331353 1117 dbSNP
rs1198640371 1120 dbSNP
rs1242278816 1126 dbSNP
rs1488819266 1130 dbSNP
rs1266045373 1131 dbSNP
rs1015081552 1134 dbSNP
rs1353569555 1137 dbSNP
rs962633222 1144 dbSNP
rs532572740 1147 dbSNP
rs1031509121 1148 dbSNP
rs371390624 1163 dbSNP
rs917146284 1163 dbSNP
rs992755176 1163 dbSNP
rs74551083 1164 dbSNP
rs1219077618 1172 dbSNP
rs948415708 1184 dbSNP
rs1296046590 1187 dbSNP
rs11540409 1195 dbSNP
rs1399358351 1199 dbSNP
rs191301928 1202 dbSNP
rs1359620041 1205 dbSNP
rs1334984522 1208 dbSNP
rs1416209558 1210 dbSNP
rs1423406915 1214 dbSNP
rs764363212 1223 dbSNP
rs1478237633 1228 dbSNP
rs1426236174 1245 dbSNP
rs909659863 1245 dbSNP
rs920630801 1245 dbSNP
rs565969307 1246 dbSNP
rs534774539 1251 dbSNP
rs1036701558 1253 dbSNP
rs554682628 1254 dbSNP
rs568321643 1256 dbSNP
rs1424796384 1258 dbSNP
rs753941977 1276 dbSNP
rs537453537 1281 dbSNP
rs1051307444 1282 dbSNP
rs1379853161 1285 dbSNP
rs890029860 1290 dbSNP
rs556153805 1294 dbSNP
rs1466359487 1303 dbSNP
rs1402702040 1310 dbSNP
rs980868306 1312 dbSNP
rs141757268 1313 dbSNP
rs1022291988 1323 dbSNP
rs939437259 1326 dbSNP
rs1318744991 1327 dbSNP
rs1184129523 1338 dbSNP
rs1472059745 1358 dbSNP
rs903813561 1360 dbSNP
rs1198667825 1365 dbSNP
rs1340028634 1366 dbSNP
rs545356002 1372 dbSNP
rs1197848260 1374 dbSNP
rs1052721262 1375 dbSNP
rs1317193085 1376 dbSNP
rs1031063136 1393 dbSNP
rs955875059 1399 dbSNP
rs567688281 1408 dbSNP
rs1278292406 1413 dbSNP
rs1024258145 1417 dbSNP
rs1461622830 1420 dbSNP
rs980214854 1421 dbSNP
rs116113541 1422 dbSNP
rs1336340670 1429 dbSNP
rs1043589351 1432 dbSNP
rs1441431138 1433 dbSNP
rs972471856 1448 dbSNP
rs1201360767 1450 dbSNP
rs1244634693 1451 dbSNP
rs1444709397 1460 dbSNP
rs1177525676 1464 dbSNP
rs868735460 1465 dbSNP
rs865835568 1466 dbSNP
rs1286647936 1471 dbSNP
rs1241036841 1473 dbSNP
rs541118875 1474 dbSNP
rs1307098881 1482 dbSNP
rs1391073603 1493 dbSNP
rs899510808 1500 dbSNP
rs185638636 1504 dbSNP
rs1158892520 1515 dbSNP
rs573666533 1516 dbSNP
rs1434723082 1518 dbSNP
rs1365574579 1526 dbSNP
rs1159765476 1527 dbSNP
rs1401265116 1537 dbSNP
rs1468083433 1538 dbSNP
rs58147311 1540 dbSNP
rs34669702 1541 dbSNP
rs1407204338 1555 dbSNP
rs1051195898 1556 dbSNP
rs1050815469 1557 dbSNP
rs750833413 1561 dbSNP
rs11254 1576 dbSNP
rs1015548268 1577 dbSNP
rs145301258 1578 dbSNP
rs1240414157 1583 dbSNP
rs554587088 1584 dbSNP
rs1238397218 1586 dbSNP
rs1313037521 1590 dbSNP
rs747640851 1591 dbSNP
rs1027871508 1597 dbSNP
rs903865970 1598 dbSNP
rs1341428543 1604 dbSNP
rs1225807399 1605 dbSNP
rs1402431043 1614 dbSNP
rs1264601591 1615 dbSNP
rs969388518 1616 dbSNP
rs556920424 1618 dbSNP
rs1466101582 1625 dbSNP
rs1052544029 1631 dbSNP
rs896560411 1637 dbSNP
rs980794400 1639 dbSNP
rs1479870077 1651 dbSNP
rs1439442048 1655 dbSNP
rs867197403 1664 dbSNP
rs1377044924 1665 dbSNP
rs1479333364 1671 dbSNP
rs142499825 1672 dbSNP
rs961114420 1673 dbSNP
rs545282560 1677 dbSNP
rs112931002 1679 dbSNP
rs1483609538 1682 dbSNP
rs1465327414 1694 dbSNP
rs755517151 1704 dbSNP
rs988234407 1705 dbSNP
rs552481035 1709 dbSNP
rs1218927206 1717 dbSNP
rs1398694086 1721 dbSNP
rs1392072580 1723 dbSNP
rs1323470401 1727 dbSNP
rs1344233223 1729 dbSNP
rs1295482932 1733 dbSNP
rs777345546 1743 dbSNP
rs1403727498 1746 dbSNP
rs1284329012 1747 dbSNP
rs1024139521 1753 dbSNP
rs979335956 1754 dbSNP
rs1226269100 1773 dbSNP
rs921152255 1774 dbSNP
rs1400547315 1776 dbSNP
rs1172611872 1778 dbSNP
rs1476713981 1786 dbSNP
rs1372489522 1790 dbSNP
rs115610654 1796 dbSNP
rs1425412266 1798 dbSNP
rs1050743759 1799 dbSNP
rs536137129 1803 dbSNP
rs1280077350 1805 dbSNP
rs1181778519 1815 dbSNP
rs548229218 1816 dbSNP
rs1461075489 1839 dbSNP
rs572728849 1845 dbSNP
rs1200981985 1852 dbSNP
rs1195947678 1856 dbSNP
rs1036751573 1865 dbSNP
rs568559864 1869 dbSNP
rs1246211921 1871 dbSNP
rs962426025 1880 dbSNP
rs748855794 1883 dbSNP
rs994973972 1884 dbSNP
rs918368267 1893 dbSNP
rs1027809371 1897 dbSNP
rs1463678847 1912 dbSNP
rs1395507581 1919 dbSNP
rs537015591 1925 dbSNP
rs1269358590 1928 dbSNP
rs911402802 1937 dbSNP
rs1181865672 1941 dbSNP
rs770642591 1946 dbSNP
rs774268681 1953 dbSNP
rs557308643 1954 dbSNP
rs570784300 1960 dbSNP
rs745699366 1965 dbSNP
rs1290215051 1967 dbSNP
rs988633335 1972 dbSNP
rs1021014243 1987 dbSNP
rs1462550416 1988 dbSNP
rs1244676523 1989 dbSNP
rs942833749 1990 dbSNP
rs538931076 1992 dbSNP
rs1044001095 1997 dbSNP
rs1364178004 2000 dbSNP
rs1427148046 2009 dbSNP
rs1304082779 2020 dbSNP
rs775626705 2021 dbSNP
rs1324021278 2027 dbSNP
rs558935006 2027 dbSNP
rs967868282 2034 dbSNP
rs1380925854 2045 dbSNP
rs935349221 2045 dbSNP
rs1420159252 2053 dbSNP
rs1292996805 2057 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Disease 2114.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM714644. RNA binding protein: AGO2. Condition:completeT1 ...

- Kishore S; Jaskiewicz L; Burger L; Hausser et al., 2011, Nature methods.

Article - Kishore S; Jaskiewicz L; Burger L; Hausser et al.
- Nature methods, 2011
Cross-linking and immunoprecipitation (CLIP) is increasingly used to map transcriptome-wide binding sites of RNA-binding proteins. We developed a method for CLIP data analysis, and applied it to compare CLIP with photoactivatable ribonucleoside-enhanced CLIP (PAR-CLIP) and to uncover how differences in cross-linking and ribonuclease digestion affect the identified sites. We found only small differences in accuracies of these methods in identifying binding sites of HuR, which binds low-complexity sequences, and Argonaute 2, which has a complex binding specificity. We found that cross-link-induced mutations led to single-nucleotide resolution for both PAR-CLIP and CLIP. Our results confirm the expectation from original CLIP publications that RNA-binding proteins do not protect their binding sites sufficiently under the denaturing conditions used during the CLIP procedure, and we show that extensive digestion with sequence-specific RNases strongly biases the recovered binding sites. This bias can be substantially reduced by milder nuclease digestion conditions.
LinkOut: [PMID: 21572407]
CLIP-seq Support 1 for dataset GSM714644
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / completeT1, repA
Location of target site ENST00000360214.3 | 3UTR | UUUUAUUUCAUUUUUCAAUAGCACAUAUGGAAU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 21572407 / GSE28865
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
168 hsa-miR-548ap-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT059371 ANP32E acidic nuclear phosphoprotein 32 family member E 2 2
MIRT072854 ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 2 6
MIRT076951 PCGF2 polycomb group ring finger 2 2 6
MIRT083943 TFAP2C transcription factor AP-2 gamma 2 2
MIRT085407 ETS2 ETS proto-oncogene 2, transcription factor 2 2
MIRT109797 KLHL15 kelch like family member 15 2 2
MIRT114053 AKAP11 A-kinase anchoring protein 11 2 10
MIRT130205 TXNIP thioredoxin interacting protein 2 6
MIRT150038 MIDN midnolin 2 2
MIRT181263 ASH1L ASH1 like histone lysine methyltransferase 2 2
MIRT205597 NCL nucleolin 2 2
MIRT222256 ACTB actin beta 2 4
MIRT245657 EIF5AL1 eukaryotic translation initiation factor 5A-like 1 2 4
MIRT250952 CDK5R1 cyclin dependent kinase 5 regulatory subunit 1 2 4
MIRT252500 NWD1 NACHT and WD repeat domain containing 1 2 2
MIRT271995 ARF1 ADP ribosylation factor 1 2 4
MIRT280806 RNF11 ring finger protein 11 2 2
MIRT293808 FEM1A fem-1 homolog A 2 2
MIRT318235 RREB1 ras responsive element binding protein 1 2 2
MIRT341461 ATP6V0B ATPase H+ transporting V0 subunit b 2 2
MIRT347424 CEBPG CCAAT/enhancer binding protein gamma 2 4
MIRT351865 PLEKHA3 pleckstrin homology domain containing A3 2 2
MIRT357988 GRPEL2 GrpE like 2, mitochondrial 2 2
MIRT377096 PPP1CB protein phosphatase 1 catalytic subunit beta 2 2
MIRT407313 IGFBP5 insulin like growth factor binding protein 5 2 2
MIRT441565 LMOD3 leiomodin 3 2 2
MIRT442365 ZC3H12C zinc finger CCCH-type containing 12C 2 2
MIRT443229 ARL5B ADP ribosylation factor like GTPase 5B 2 2
MIRT443405 HMX3 H6 family homeobox 3 2 2
MIRT446056 NR5A2 nuclear receptor subfamily 5 group A member 2 2 2
MIRT448278 ZNF652 zinc finger protein 652 2 2
MIRT450823 KCNB1 potassium voltage-gated channel subfamily B member 1 2 2
MIRT453017 CCDC115 coiled-coil domain containing 115 2 17
MIRT454464 PPP2R2B protein phosphatase 2 regulatory subunit Bbeta 2 2
MIRT456361 CITED2 Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2 2 2
MIRT460008 DNALI1 dynein axonemal light intermediate chain 1 2 2
MIRT463155 ZNF385A zinc finger protein 385A 2 6
MIRT463767 YPEL2 yippee like 2 2 2
MIRT468311 SFT2D2 SFT2 domain containing 2 2 2
MIRT470669 POLR2D RNA polymerase II subunit D 2 4
MIRT478518 CTTN cortactin 2 2
MIRT480508 C11orf57 chromosome 11 open reading frame 57 2 2
MIRT484719 INHBA inhibin beta A subunit 2 12
MIRT485495 HMGN2 high mobility group nucleosomal binding domain 2 2 2
MIRT487303 SLC38A9 solute carrier family 38 member 9 2 2
MIRT487772 ANKEF1 ankyrin repeat and EF-hand domain containing 1 2 16
MIRT491877 YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta 2 2
MIRT494305 CEP120 centrosomal protein 120 2 2
MIRT495397 TRIM24 tripartite motif containing 24 2 2
MIRT495647 CDK1 cyclin dependent kinase 1 2 2
MIRT496666 TMEM237 transmembrane protein 237 2 2
MIRT496838 ZNF460 zinc finger protein 460 2 2
MIRT498639 CHD4 chromodomain helicase DNA binding protein 4 2 10
MIRT503929 FBXL13 F-box and leucine rich repeat protein 13 2 4
MIRT506064 PPP2R2A protein phosphatase 2 regulatory subunit Balpha 2 2
MIRT506583 MIER3 MIER family member 3 2 4
MIRT506607 MAT2A methionine adenosyltransferase 2A 2 4
MIRT506845 KIF23 kinesin family member 23 2 6
MIRT508537 RPP14 ribonuclease P/MRP subunit p14 2 4
MIRT509670 ZNF354B zinc finger protein 354B 2 10
MIRT511171 MBNL3 muscleblind like splicing regulator 3 2 6
MIRT512148 COX6B1 cytochrome c oxidase subunit 6B1 2 2
MIRT512832 ID4 inhibitor of DNA binding 4, HLH protein 2 6
MIRT514559 XRCC3 X-ray repair cross complementing 3 2 4
MIRT515857 AJAP1 adherens junctions associated protein 1 2 4
MIRT521849 PNISR PNN interacting serine and arginine rich protein 2 4
MIRT525365 SYNM synemin 2 2
MIRT527121 ARHGAP15 Rho GTPase activating protein 15 2 2
MIRT527272 FBLN2 fibulin 2 2 2
MIRT527440 COL4A3 collagen type IV alpha 3 chain 2 2
MIRT527659 CD300E CD300e molecule 2 2
MIRT528335 TBC1D22B TBC1 domain family member 22B 2 2
MIRT529035 EXOC8 exocyst complex component 8 2 2
MIRT529322 PDE5A phosphodiesterase 5A 2 2
MIRT529678 TRPV2 transient receptor potential cation channel subfamily V member 2 2 2
MIRT529847 SMTN smoothelin 2 2
MIRT530386 ZNF431 zinc finger protein 431 2 2
MIRT530914 GPR85 G protein-coupled receptor 85 2 2
MIRT531795 KDR kinase insert domain receptor 2 2
MIRT532247 KLF2 Kruppel like factor 2 2 4
MIRT532659 CBX7 chromobox 7 2 2
MIRT533632 TMX3 thioredoxin related transmembrane protein 3 2 2
MIRT534812 RAB33B RAB33B, member RAS oncogene family 2 2
MIRT534976 PSD3 pleckstrin and Sec7 domain containing 3 2 2
MIRT536589 ITPKB inositol-trisphosphate 3-kinase B 2 2
MIRT536780 HNRNPD heterogeneous nuclear ribonucleoprotein D 2 2
MIRT538765 CABLES1 Cdk5 and Abl enzyme substrate 1 2 2
MIRT539296 ANGEL2 angel homolog 2 2 2
MIRT539622 SHISA9 shisa family member 9 2 2
MIRT539652 BUB1 BUB1 mitotic checkpoint serine/threonine kinase 2 2
MIRT540348 OPHN1 oligophrenin 1 2 2
MIRT540414 PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 2 2
MIRT541397 CDC27 cell division cycle 27 2 2
MIRT542917 HSBP1 heat shock factor binding protein 1 2 2
MIRT544711 EIF5A eukaryotic translation initiation factor 5A 2 4
MIRT544999 MFF mitochondrial fission factor 2 4
MIRT553290 TSPAN3 tetraspanin 3 2 2
MIRT553456 TNRC6C trinucleotide repeat containing 6C 2 2
MIRT553783 TAF13 TATA-box binding protein associated factor 13 2 2
MIRT554657 ROBO1 roundabout guidance receptor 1 2 2
MIRT555105 PURB purine rich element binding protein B 2 2
MIRT557236 HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 2 2
MIRT560862 GAL3ST3 galactose-3-O-sulfotransferase 3 2 2
MIRT561544 SON SON DNA binding protein 2 2
MIRT561555 SLMO2 PRELI domain containing 3B 2 2
MIRT563765 ZNF678 zinc finger protein 678 2 2
MIRT565654 SIX4 SIX homeobox 4 2 2
MIRT568081 CELF2 CUGBP Elav-like family member 2 2 2
MIRT568760 MYBL1 MYB proto-oncogene like 1 2 2
MIRT569079 CADM2 cell adhesion molecule 2 2 2
MIRT569510 THYN1 thymocyte nuclear protein 1 2 2
MIRT571269 CDKN2AIP CDKN2A interacting protein 2 2
MIRT571810 PHF19 PHD finger protein 19 2 2
MIRT572555 DKK3 dickkopf WNT signaling pathway inhibitor 3 2 2
MIRT573783 SLC24A4 solute carrier family 24 member 4 2 4
MIRT576442 Ccdc115 coiled-coil domain containing 115 2 10
MIRT576713 Slc30a3 solute carrier family 30 (zinc transporter), member 3 2 3
MIRT608378 PIWIL2 piwi like RNA-mediated gene silencing 2 2 2
MIRT608485 NKTR natural killer cell triggering receptor 2 6
MIRT610187 FAM49A family with sequence similarity 49 member A 2 2
MIRT611632 EDIL3 EGF like repeats and discoidin domains 3 2 2
MIRT613535 TRA2B transformer 2 beta homolog 2 2
MIRT616222 PTPN11 protein tyrosine phosphatase, non-receptor type 11 2 2
MIRT622371 SALL1 spalt like transcription factor 1 2 2
MIRT624372 CDK12 cyclin dependent kinase 12 2 2
MIRT624996 ZNF665 zinc finger protein 665 2 4
MIRT626876 AP3B1 adaptor related protein complex 3 beta 1 subunit 2 2
MIRT627738 RAP2B RAP2B, member of RAS oncogene family 2 4
MIRT628491 ADAT2 adenosine deaminase, tRNA specific 2 2 2
MIRT633648 PLEKHG7 pleckstrin homology and RhoGEF domain containing G7 2 4
MIRT634029 SLC30A3 solute carrier family 30 member 3 2 3
MIRT635924 GLTSCR2 NOP53 ribosome biogenesis factor 2 2
MIRT638288 SERBP1 SERPINE1 mRNA binding protein 1 2 2
MIRT641960 RNF115 ring finger protein 115 2 2
MIRT643574 CTNNA3 catenin alpha 3 2 2
MIRT645181 NOL9 nucleolar protein 9 2 4
MIRT647498 ZNF639 zinc finger protein 639 2 2
MIRT647683 PCK1 phosphoenolpyruvate carboxykinase 1 2 2
MIRT648423 MYOZ3 myozenin 3 2 2
MIRT650114 ZCCHC9 zinc finger CCHC-type containing 9 2 2
MIRT651077 ZNF518B zinc finger protein 518B 2 4
MIRT651416 ZADH2 zinc binding alcohol dehydrogenase domain containing 2 2 2
MIRT651457 XKR4 XK related 4 2 2
MIRT653620 SLC30A4 solute carrier family 30 member 4 2 2
MIRT653638 SLC30A1 solute carrier family 30 member 1 2 2
MIRT654897 POU2F1 POU class 2 homeobox 1 2 2
MIRT656484 MAP3K9 mitogen-activated protein kinase kinase kinase 9 2 2
MIRT658017 GABRA4 gamma-aminobutyric acid type A receptor alpha4 subunit 2 2
MIRT658042 FZD10 frizzled class receptor 10 2 2
MIRT660094 BTBD3 BTB domain containing 3 2 2
MIRT663924 MAGEF1 MAGE family member F1 2 2
MIRT665883 TGIF2 TGFB induced factor homeobox 2 2 2
MIRT669052 CEP128 centrosomal protein 128 2 2
MIRT669712 AAGAB alpha and gamma adaptin binding protein 2 2
MIRT686813 SNX2 sorting nexin 2 2 4
MIRT689884 SOD2 superoxide dismutase 2 2 2
MIRT693275 GLRX2 glutaredoxin 2 2 4
MIRT697057 BCAR1 BCAR1, Cas family scaffolding protein 2 2
MIRT703298 GID4 GID complex subunit 4 homolog 2 2
MIRT704088 DYRK2 dual specificity tyrosine phosphorylation regulated kinase 2 2 2
MIRT707720 CDC6 cell division cycle 6 2 2
MIRT708137 GK5 glycerol kinase 5 (putative) 2 2
MIRT709213 KLHL30 kelch like family member 30 2 2
MIRT710063 RWDD2A RWD domain containing 2A 2 2
MIRT712771 POU6F2 POU class 6 homeobox 2 2 2
MIRT715074 TMTC1 transmembrane and tetratricopeptide repeat containing 1 2 2
MIRT715388 TADA3 transcriptional adaptor 3 2 2
MIRT717713 NCKAP1 NCK associated protein 1 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-548ap Tripterygium wilfordii Hook F resistant tissue
hsa-miR-548ap-3p Gefitinib 123631 NSC715055 approved sensitive cell line (PC9)
hsa-miR-548ap-3p Osimertinib 71496458 NSC779217 approved sensitive cell line (PC9)
hsa-miR-548ap-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A2780)

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