miRTarBase - #MIRT090615


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pre-miRNA Information
pre-miRNA hsa-mir-137   
Genomic Coordinates chr1: 98046070 - 98046171
Description Homo sapiens miR-137 stem-loop
Comment This miRNA sequence is predicted based on homology to a verified miRNA from mouse .
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-137
Sequence 59| UUAUUGCUUAAGAAUACGCGUAG |81
Evidence Experimental
Experiments Cloned
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Biomarker Information
Biomarker ID Name Type Discovered From Mode Level Source Testing Methods
B41RDC miR-137 Safety Biomarker (SAF) Clinical/Experimental Data Expression Decrease Neuron Reverse transcription-polymerase chain reaction
Gene Information
Gene Symbol PLS1   
Synonyms -
Description plastin 1
Transcript NM_001145319   
Other Transcripts NM_001172312 , NM_002670   
Expression
Putative miRNA Targets on PLS1
3'UTR of PLS1
(miRNA target sites are highlighted)		 
>PLS1|NM_001145319|3'UTR
   1 TCATTTCATATGATTTTCTGCCACATTAAACATATTGTATGCCTCACAGTTTACAGGATTCTGAAATGTAGTGGGTGTAA
  81 AACCAGAGATTATTTGTATGCTCAAAATAGTTATATATTCATTAATGAATTCAATATCCTGTTCATACTAGTTAGAGCTG
 161 GTCAGCCTTTTTGGGTAACACAGTTAATTTACCAACTGATACAGATAATAGAATATATTCATAATCAAGCTGATACTTCA
 241 TGATTAAATTATTTTTGTTGCTTAAAAGTCGTATTAGACAAGACTAAATCATTCTTTTTTATGGTTCAAAAAAGATGAAT
 321 ACAAACGTTTTTGCAGGTTCTGCTGTGAAATGTGGTTTGATTTTTTTGGTGTGTTAATTTTGATCATAAATGCATTCATA
 401 CTCATAATCCAGTTTAATCCTTTTATTTGCTTCCTCCAACTATTTAAAGTGGTCCAAAAACACTTTTCTGTAAGTTTCTA
 481 TACTGTCTAAAACCTTATGGTGACCAGAATTGTTTATTAATATCAAACTTTTTTATATATGAGAACTAATTCTTGAATAA
 561 ACCCCAAAGTTCACTCTCTTGTTTAAGTAGCAGCAGCTTTTTACTTAAAATTTAATTTTAACTACATTGATACTTTACAC
 641 ATCCTAGTTTGGTAACACAGCTTTAACTATGTCATGCAACATATATATGTTGGTAGGATGTTATTAGAGAGATATGTGTG
 721 CATATATATTTTTTTGCACCTGAATCACCCAGCTTTTCATAAGTGGTATGTTTAATTGGTCATTCAGCCAACCATCAGTA
 801 TTTTCCCCCCACAACATGTGTAACACTTTTCAGTCTGTGGATATCTGATACATTAAGATTTCTTTTTATAAGTATTCATT
 881 TTGAATGTGCATATAGTTATTTGACCCCTTCCAAATACTTGTAGCCAAACATTGGCTAGAACATCCCAAGATATGCTGAC
 961 ACTGTCCTGTTAGCTTCATATTATACTTGCTAGTTTAGGTCTCTATAGAAGCCCTATATAATTTAGAATATGCCCACTGA
1041 ATATCTTTAATAGAAAGTAACATAAAGCTAGTATTCAATGTAGAGTATTTTCATATGTTTTTCACAGCCCGTTACAAATT
1121 GGCAATGTTTGGTTAATGTTTGTATTACTTGGAAATCGCTACAGCTTGGACTATTTTTTTCTAAATTTTTAGCATTAGTC
1201 CATTTCTGCTGCTAACAATTGAATCCAGAAATCTACTTTCTCCATCTTCCACTGTTAGTGCCAGTGAGCAATACTGTTGT
1281 GCAACAAAAATGTCACTTTATCTCAGTGTGAATGAGTAGTCTAAATTCCCTTTCTACCATTGATTTAAATATATATATTG
1361 GTAAGAGAGACTGCCCATGTGTTTAGAATAGAATTTTTTAAATGAAATGATCAACAGGTGGAATTTGAAATATATTCTTC
1441 TACAAAAGAGATTTCTTTCCCTTTTATATTTTGATGATTGTTTTCTTAAGATTAAGATATGTTCTTGCTCTTTTATAAGA
1521 TTATTTAAATTATGTTTCCCTCTGATTTTTTTTCACCATTGTATTTACTAAGTTATTGGATTTACATGAAATCTGGCACT
1601 TTAGGGTGTTCTTTTTCTCACAGAGTATATTTAATAAAAATGCTGTGTATATAGAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' gaugcgcauaagaAUUCGUUAUu 5'
                       |:||||||| 
Target 5' ctgttagtgccagTGAGCAATAc 3'
 1252 - 1274 146.00 -9.10
2 
miRNA  3' gaugCGCAUAAGAAUUCGUUAUu 5'
              || | ||| ||||:::|| 
Target 5' cccaGC-TTTTCATAAGTGGTAt 3'
 748 - 769 118.00 -5.80
3 
miRNA  3' gaUGCGCAUAAG---AAUUCGUUAUu 5'
            :| ||| | |   || :|||||: 
Target 5' caGCCCGT-TACAAATT-GGCAATGt 3'
 1105 - 1128 115.00 -7.66
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN14037858 3 COSMIC
COSN31583505 3 COSMIC
COSN30491197 13 COSMIC
COSN28817981 21 COSMIC
COSN30153555 40 COSMIC
COSN31597732 57 COSMIC
COSN30494855 92 COSMIC
COSN31500494 104 COSMIC
COSN31527591 133 COSMIC
COSN18728055 146 COSMIC
COSN31576159 205 COSMIC
COSN26645161 212 COSMIC
COSN31516431 421 COSMIC
COSN31528359 535 COSMIC
COSN16385950 597 COSMIC
COSN28772521 603 COSMIC
COSN30165673 664 COSMIC
COSN8488383 748 COSMIC
COSN30542390 816 COSMIC
COSN31569657 827 COSMIC
COSN31534672 863 COSMIC
COSN28196152 963 COSMIC
COSN31532156 1123 COSMIC
COSN30172048 1256 COSMIC
COSN9132415 1268 COSMIC
COSN28730141 1416 COSMIC
COSN19107720 1419 COSMIC
COSN31482443 1517 COSMIC
COSN31523439 1546 COSMIC
COSN28751611 1564 COSMIC
COSN21755616 1570 COSMIC
COSN31570580 1644 COSMIC
rs3773506 152 GWAS
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs371036980 3 dbSNP
rs747229015 5 dbSNP
rs373574744 10 dbSNP
rs749730736 12 dbSNP
rs3773505 21 dbSNP
rs761805558 26 dbSNP
rs1197113138 37 dbSNP
rs1431184867 38 dbSNP
rs931266556 43 dbSNP
rs751917054 49 dbSNP
rs1218241487 69 dbSNP
rs537458330 73 dbSNP
rs890911268 75 dbSNP
rs550414857 95 dbSNP
rs1316149592 97 dbSNP
rs1303424941 99 dbSNP
rs568680819 106 dbSNP
rs1039548195 115 dbSNP
rs567144440 135 dbSNP
rs1046181412 137 dbSNP
rs3773506 152 dbSNP
rs1156413743 154 dbSNP
rs1390576403 165 dbSNP
rs1378886240 176 dbSNP
rs1176111025 178 dbSNP
rs1401021317 178 dbSNP
rs779855540 179 dbSNP
rs1432062187 181 dbSNP
rs553083450 203 dbSNP
rs1425146630 206 dbSNP
rs1192295397 210 dbSNP
rs572715984 223 dbSNP
rs937746861 227 dbSNP
rs781578561 235 dbSNP
rs1032287256 237 dbSNP
rs1329245125 242 dbSNP
rs1438762455 243 dbSNP
rs1257865759 258 dbSNP
rs140467125 269 dbSNP
rs1311654044 271 dbSNP
rs558282952 272 dbSNP
rs1377386085 287 dbSNP
rs1010277544 291 dbSNP
rs1020702952 293 dbSNP
rs145639846 295 dbSNP
rs560400018 295 dbSNP
rs577935277 296 dbSNP
rs998787738 299 dbSNP
rs981897383 304 dbSNP
rs1350172064 308 dbSNP
rs1403957563 316 dbSNP
rs1303045830 317 dbSNP
rs1019668446 318 dbSNP
rs543476141 327 dbSNP
rs1034535903 328 dbSNP
rs1172319295 329 dbSNP
rs1442024809 335 dbSNP
rs1270195835 338 dbSNP
rs1351891138 341 dbSNP
rs1209588054 343 dbSNP
rs562143471 344 dbSNP
rs1417669014 352 dbSNP
rs1258585853 356 dbSNP
rs201019563 360 dbSNP
rs1028196343 361 dbSNP
rs1278217564 361 dbSNP
rs1218737001 376 dbSNP
rs974193490 392 dbSNP
rs1354284156 399 dbSNP
rs1285186715 401 dbSNP
rs952645653 405 dbSNP
rs1268979649 413 dbSNP
rs574631156 434 dbSNP
rs1342029773 436 dbSNP
rs1313073373 438 dbSNP
rs542149987 440 dbSNP
rs908418864 442 dbSNP
rs758776272 443 dbSNP
rs930219566 454 dbSNP
rs1299442037 455 dbSNP
rs982451447 462 dbSNP
rs961045532 479 dbSNP
rs1470412610 481 dbSNP
rs912180537 499 dbSNP
rs943816554 502 dbSNP
rs927596280 505 dbSNP
rs1039838273 511 dbSNP
rs1370556324 521 dbSNP
rs1188509629 523 dbSNP
rs937815269 545 dbSNP
rs546233644 547 dbSNP
rs1388561149 553 dbSNP
rs1255535178 564 dbSNP
rs538803503 569 dbSNP
rs182984096 584 dbSNP
rs1053613347 589 dbSNP
rs947504926 621 dbSNP
rs1358209212 629 dbSNP
rs1265750137 632 dbSNP
rs1408034343 634 dbSNP
rs1332166006 638 dbSNP
rs1279663274 639 dbSNP
rs892429316 641 dbSNP
rs1400128380 648 dbSNP
rs1043309922 650 dbSNP
rs1290487354 658 dbSNP
rs1009447087 659 dbSNP
rs527486477 668 dbSNP
rs999048135 670 dbSNP
rs1041045780 679 dbSNP
rs901164175 684 dbSNP
rs61300208 685 dbSNP
rs907167387 692 dbSNP
rs1478227877 706 dbSNP
rs1262484393 712 dbSNP
rs1190955364 717 dbSNP
rs1282787198 720 dbSNP
rs1002974495 722 dbSNP
rs1028792451 726 dbSNP
rs1209062569 728 dbSNP
rs1358832929 728 dbSNP
rs952578471 740 dbSNP
rs1247360245 754 dbSNP
rs113701387 760 dbSNP
rs1316751355 766 dbSNP
rs1267836946 770 dbSNP
rs776640432 775 dbSNP
rs745954180 777 dbSNP
rs958768196 784 dbSNP
rs1440705005 786 dbSNP
rs772306705 790 dbSNP
rs1027106302 792 dbSNP
rs1392731988 797 dbSNP
rs144325701 799 dbSNP
rs1482457917 803 dbSNP
rs1423034147 805 dbSNP
rs1202367264 806 dbSNP
rs951640458 807 dbSNP
rs1479031109 809 dbSNP
rs1378181367 811 dbSNP
rs961308819 812 dbSNP
rs983411137 817 dbSNP
rs1467018965 847 dbSNP
rs1239699295 852 dbSNP
rs1198894358 853 dbSNP
rs1457012341 855 dbSNP
rs1270413394 860 dbSNP
rs769930632 864 dbSNP
rs965440838 866 dbSNP
rs775770833 869 dbSNP
rs1234115804 873 dbSNP
rs1369262174 879 dbSNP
rs1186656535 894 dbSNP
rs1311855305 897 dbSNP
rs1366499444 908 dbSNP
rs116737586 909 dbSNP
rs921049913 920 dbSNP
rs775536023 930 dbSNP
rs1416299684 942 dbSNP
rs35658082 945 dbSNP
rs1389446821 949 dbSNP
rs1402992250 951 dbSNP
rs936405445 955 dbSNP
rs1172938513 962 dbSNP
rs1053623306 964 dbSNP
rs1427964529 974 dbSNP
rs1381961049 979 dbSNP
rs13322816 985 dbSNP
rs1438831014 993 dbSNP
rs188771108 996 dbSNP
rs1395678117 1015 dbSNP
rs548113493 1017 dbSNP
rs544589907 1018 dbSNP
rs1342657594 1019 dbSNP
rs1453778447 1029 dbSNP
rs1297559056 1033 dbSNP
rs1340629928 1036 dbSNP
rs192089261 1038 dbSNP
rs1003314681 1041 dbSNP
rs1210827381 1048 dbSNP
rs1346291021 1052 dbSNP
rs1055791242 1058 dbSNP
rs934951407 1059 dbSNP
rs1241390104 1064 dbSNP
rs894603099 1065 dbSNP
rs995510048 1075 dbSNP
rs1041273622 1081 dbSNP
rs1252546350 1093 dbSNP
rs901181527 1094 dbSNP
rs558258157 1101 dbSNP
rs576586395 1109 dbSNP
rs1027124224 1110 dbSNP
rs73864409 1111 dbSNP
rs555470101 1112 dbSNP
rs184397020 1115 dbSNP
rs1164651231 1120 dbSNP
rs1472894960 1121 dbSNP
rs541713499 1128 dbSNP
rs1005622264 1131 dbSNP
rs1462518908 1136 dbSNP
rs1488971381 1145 dbSNP
rs1015475250 1158 dbSNP
rs367995120 1159 dbSNP
rs1003471701 1163 dbSNP
rs1035312605 1170 dbSNP
rs1247409513 1174 dbSNP
rs189542504 1176 dbSNP
rs1357266830 1179 dbSNP
rs1292885139 1208 dbSNP
rs148359397 1217 dbSNP
rs1373734306 1220 dbSNP
rs1021947021 1222 dbSNP
rs968223875 1230 dbSNP
rs545615083 1234 dbSNP
rs1343240190 1241 dbSNP
rs1465563272 1253 dbSNP
rs975524899 1267 dbSNP
rs977805802 1275 dbSNP
rs1408529019 1283 dbSNP
rs767574497 1285 dbSNP
rs1416778956 1292 dbSNP
rs1162332336 1293 dbSNP
rs924814077 1297 dbSNP
rs1423635231 1303 dbSNP
rs957780937 1306 dbSNP
rs1187623948 1307 dbSNP
rs989198881 1312 dbSNP
rs1320290261 1320 dbSNP
rs1224307253 1330 dbSNP
rs541153125 1331 dbSNP
rs1384423549 1335 dbSNP
rs1231617705 1337 dbSNP
rs922820181 1349 dbSNP
rs563967707 1354 dbSNP
rs1213948745 1359 dbSNP
rs945213399 1364 dbSNP
rs1359832391 1381 dbSNP
rs1295193114 1392 dbSNP
rs1437000882 1394 dbSNP
rs1046215673 1404 dbSNP
rs1393451399 1408 dbSNP
rs932681839 1411 dbSNP
rs866652558 1421 dbSNP
rs1050214530 1428 dbSNP
rs376056602 1431 dbSNP
rs1193425214 1435 dbSNP
rs369382953 1438 dbSNP
rs1454989003 1445 dbSNP
rs1296847610 1452 dbSNP
rs1212080093 1453 dbSNP
rs927904788 1456 dbSNP
rs941460022 1467 dbSNP
rs771763983 1475 dbSNP
rs937939581 1478 dbSNP
rs1203973701 1483 dbSNP
rs1305824285 1486 dbSNP
rs550342275 1486 dbSNP
rs1253931124 1488 dbSNP
rs201950991 1494 dbSNP
rs776214325 1494 dbSNP
rs192351659 1500 dbSNP
rs894452950 1501 dbSNP
rs931416333 1505 dbSNP
rs1369990182 1506 dbSNP
rs1300916183 1511 dbSNP
rs1048485908 1519 dbSNP
rs1448568966 1521 dbSNP
rs537550999 1523 dbSNP
rs1400625110 1527 dbSNP
rs1267266144 1538 dbSNP
rs1297240775 1540 dbSNP
rs1460087731 1541 dbSNP
rs1463335115 1546 dbSNP
rs141529177 1547 dbSNP
rs1004825325 1556 dbSNP
rs867554205 1557 dbSNP
rs1192199574 1559 dbSNP
rs1441907309 1560 dbSNP
rs1251585098 1564 dbSNP
rs1176830458 1569 dbSNP
rs1479700966 1573 dbSNP
rs1019780481 1584 dbSNP
rs1211531018 1586 dbSNP
rs901425976 1593 dbSNP
rs1432709894 1600 dbSNP
rs1196813518 1607 dbSNP
rs1347005657 1609 dbSNP
rs1278058597 1610 dbSNP
rs1431793963 1619 dbSNP
rs1242111784 1621 dbSNP
rs1377361025 1622 dbSNP
rs1012146513 1623 dbSNP
rs1022415133 1626 dbSNP
rs1380744196 1627 dbSNP
rs1302878327 1640 dbSNP
rs1413599561 1647 dbSNP
rs561522879 1653 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Disease 5357.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM714644. RNA binding protein: AGO2. Condition:completeT1 ...

- Kishore S; Jaskiewicz L; Burger L; Hausser et al., 2011, Nature methods.

Article - Kishore S; Jaskiewicz L; Burger L; Hausser et al.
- Nature methods, 2011
Cross-linking and immunoprecipitation (CLIP) is increasingly used to map transcriptome-wide binding sites of RNA-binding proteins. We developed a method for CLIP data analysis, and applied it to compare CLIP with photoactivatable ribonucleoside-enhanced CLIP (PAR-CLIP) and to uncover how differences in cross-linking and ribonuclease digestion affect the identified sites. We found only small differences in accuracies of these methods in identifying binding sites of HuR, which binds low-complexity sequences, and Argonaute 2, which has a complex binding specificity. We found that cross-link-induced mutations led to single-nucleotide resolution for both PAR-CLIP and CLIP. Our results confirm the expectation from original CLIP publications that RNA-binding proteins do not protect their binding sites sufficiently under the denaturing conditions used during the CLIP procedure, and we show that extensive digestion with sequence-specific RNases strongly biases the recovered binding sites. This bias can be substantially reduced by milder nuclease digestion conditions.
LinkOut: [PMID: 21572407]
CLIP-seq Support 1 for dataset GSM714644
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / completeT1, repA
Location of target site ENST00000457734.2 | 3UTR | AAUACUGUUGUGCAACAAAAAUGUCACUUUAUCUCAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 21572407 / GSE28865
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE28544 Breast cancer 0.617 6.6e-4 0.686 1.1e-4 24 Click to see details
GSE21849 B cell lymphoma 0.476 4.5e-3 0.591 3.7e-4 29 Click to see details
GSE21687 Ependynoma primary tumors 0.224 3.8e-2 0.217 4.3e-2 64 Click to see details
GSE38226 Liver fibrosis 0.385 4.2e-2 0.326 7.5e-2 21 Click to see details
GSE42095 Differentiated embryonic stem cells 0.316 7.1e-2 0.230 1.5e-1 23 Click to see details
GSE14794 Lymphoblastoid cells 0.149 8.1e-2 0.139 9.6e-2 90 Click to see details
GSE38974 Chronic obstructive pulmonary disease 0.288 8.1e-2 0.257 1.1e-1 25 Click to see details
GSE32688 Pancreatic cancer 0.245 8.8e-2 0.232 1.0e-1 32 Click to see details
GSE17498 Multiple myeloma 0.191 1.2e-1 0.185 1.3e-1 40 Click to see details
GSE19350 CNS germ cell tumors -0.367 1.2e-1 -0.196 2.7e-1 12 Click to see details
GSE27834 Pluripotent stem cells 0.28 1.5e-1 0.282 1.4e-1 16 Click to see details
GSE26953 Aortic valvular endothelial cells -0.208 1.6e-1 0.055 4.0e-1 24 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis 0.17 2.4e-1 -0.045 4.3e-1 20 Click to see details
GSE28260 Renal cortex and medulla 0.091 3.8e-1 0.148 3.1e-1 13 Click to see details
GSE28260 Renal cortex and medulla 0.091 3.8e-1 0.148 3.1e-1 13 Click to see details
GSE28260 Renal cortex and medulla 0.091 3.8e-1 0.148 3.1e-1 13 Click to see details
GSE28260 Renal cortex and medulla 0.091 3.8e-1 0.148 3.1e-1 13 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
ESCA -0.987 0.01 -1.000 0.5 4 Click to see details
UCEC -0.889 0.06 -1.000 0.5 4 Click to see details
LIHC -0.966 0.08 -1.000 0.5 3 Click to see details
KICH -0.756 0.12 -0.800 0.1 4 Click to see details
STAD -0.31 0.15 -0.324 0.14 13 Click to see details
PAAD 0.694 0.15 0.200 0.4 4 Click to see details
HNSC 0.18 0.18 0.047 0.4 29 Click to see details
PCPG -0.818 0.2 -0.500 0.33 3 Click to see details
LUSC 0.382 0.2 0.321 0.24 7 Click to see details
BLCA 0.556 0.22 0.400 0.3 4 Click to see details
THCA 0.147 0.23 0.093 0.32 27 Click to see details
KIRP -0.251 0.27 -0.310 0.23 8 Click to see details
CHOL -0.372 0.31 0.200 0.4 4 Click to see details
PRAD -0.029 0.45 -0.083 0.35 24 Click to see details
BRCA 0.006 0.5 -0.429 0.2 6 Click to see details
BRCA 0.006 0.5 -0.429 0.2 6 Click to see details
BRCA 0.006 0.5 -0.429 0.2 6 Click to see details
BRCA 0.006 0.5 -0.429 0.2 6 Click to see details
140 hsa-miR-137 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT002489 E2F6 E2F transcription factor 6 4 1
MIRT002490 CDK6 cyclin dependent kinase 6 4 7
MIRT004004 NCOA2 nuclear receptor coactivator 2 4 1
MIRT004579 KDM1A lysine demethylase 1A 5 3
MIRT005485 CDC42 cell division cycle 42 4 4
MIRT005605 CTBP1 C-terminal binding protein 1 4 1
MIRT005883 MITF melanogenesis associated transcription factor 3 1
MIRT006329 PTGS2 prostaglandin-endoperoxide synthase 2 2 1
MIRT006957 ESRRA estrogen related receptor alpha 1 1
MIRT007068 ZNF804A zinc finger protein 804A 1 1
MIRT007092 YBX1 Y-box binding protein 1 3 3
MIRT007252 CSE1L chromosome segregation 1 like 2 1
MIRT007346 PXN paxillin 3 1
MIRT053056 GLIPR1 GLI pathogenesis related 1 3 1
MIRT053225 MET MET proto-oncogene, receptor tyrosine kinase 3 1
MIRT054547 FUNDC1 FUN14 domain containing 1 3 1
MIRT054568 BNIP3L BCL2 interacting protein 3 like 3 1
MIRT090615 PLS1 plastin 1 2 2
MIRT093393 TMA16 translation machinery associated 16 homolog 2 2
MIRT109230 VMA21 VMA21, vacuolar ATPase assembly factor 2 6
MIRT153687 NCOA3 nuclear receptor coactivator 3 2 2
MIRT170929 FOXK1 forkhead box K1 2 2
MIRT219251 RREB1 ras responsive element binding protein 1 2 2
MIRT259552 KLHL15 kelch like family member 15 2 4
MIRT271869 ZNF678 zinc finger protein 678 2 2
MIRT280623 BCL11B B-cell CLL/lymphoma 11B 2 8
MIRT293284 DR1 down-regulator of transcription 1 2 2
MIRT314017 PAPD7 poly(A) RNA polymerase D7, non-canonical 2 8
MIRT374677 AGO4 argonaute 4, RISC catalytic component 2 2
MIRT437385 FMNL2 formin like 2 1 1
MIRT437406 RORA RAR related orphan receptor A 1 1
MIRT437423 KIT KIT proto-oncogene receptor tyrosine kinase 3 1
MIRT437424 AKT2 AKT serine/threonine kinase 2 5 4
MIRT437425 TGFB2 transforming growth factor beta 2 3 1
MIRT437804 SERPINA3 serpin family A member 3 1 1
MIRT437978 COX2 cytochrome c oxidase subunit II 3 1
MIRT438078 TRIM13 tripartite motif containing 13 4 1
MIRT438287 TBX3 T-box 3 1 1
MIRT438288 KLF4 Kruppel like factor 4 1 1
MIRT438537 MTDH metadherin 2 1
MIRT438757 Nr1i3 nuclear receptor subfamily 1, group I, member 3 2 1
MIRT442564 CCDC59 coiled-coil domain containing 59 2 2
MIRT442778 JAG1 jagged 1 2 2
MIRT444302 SREK1IP1 SREK1 interacting protein 1 2 2
MIRT446969 SLCO4C1 solute carrier organic anion transporter family member 4C1 2 2
MIRT448824 FKBP1A FK506 binding protein 1A 2 4
MIRT453617 SNRPE small nuclear ribonucleoprotein polypeptide E 2 4
MIRT459217 MRPS21 mitochondrial ribosomal protein S21 2 2
MIRT463490 ZC3H11A zinc finger CCCH-type containing 11A 2 12
MIRT470084 PTGES2 prostaglandin E synthase 2 2 2
MIRT475876 H3F3C H3 histone family member 3C 2 10
MIRT475912 H3F3B H3 histone family member 3B 2 8
MIRT476669 FUT11 fucosyltransferase 11 2 10
MIRT477346 EOGT EGF domain specific O-linked N-acetylglucosamine transferase 2 4
MIRT477596 EIF1 eukaryotic translation initiation factor 1 2 10
MIRT478367 DDI2 DNA damage inducible 1 homolog 2 2 2
MIRT479111 CNN2 calponin 2 2 2
MIRT482926 CTPS2 CTP synthase 2 2 2
MIRT485083 SNRK SNF related kinase 2 12
MIRT497120 NBEAL1 neurobeachin like 1 2 2
MIRT498029 UBXN4 UBX domain protein 4 2 8
MIRT500603 UBE2Z ubiquitin conjugating enzyme E2 Z 2 4
MIRT500927 SSFA2 sperm specific antigen 2 2 8
MIRT504324 ASGR2 asialoglycoprotein receptor 2 2 6
MIRT504647 RPL9 ribosomal protein L9 2 6
MIRT506304 PCMTD1 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1 2 6
MIRT508007 BCAT1 branched chain amino acid transaminase 1 2 4
MIRT510538 XKR7 XK related 7 2 2
MIRT513051 LYPD6 LY6/PLAUR domain containing 6 2 6
MIRT515223 COX20 COX20, cytochrome c oxidase assembly factor 2 8
MIRT519857 ZFP62 ZFP62 zinc finger protein 2 6
MIRT520508 TRAM2 translocation associated membrane protein 2 2 6
MIRT522047 PAFAH1B2 platelet activating factor acetylhydrolase 1b catalytic subunit 2 2 4
MIRT524479 CHRM3 cholinergic receptor muscarinic 3 2 4
MIRT526904 ZNF772 zinc finger protein 772 2 6
MIRT527862 SLC39A14 solute carrier family 39 member 14 2 2
MIRT528601 ZNF326 zinc finger protein 326 2 2
MIRT532950 ZNF24 zinc finger protein 24 2 4
MIRT536275 LMOD2 leiomodin 2 2 2
MIRT537045 GRAMD4 GRAM domain containing 4 2 2
MIRT537124 GOLGA3 golgin A3 2 4
MIRT538884 BTBD1 BTB domain containing 1 2 2
MIRT541457 AURKA aurora kinase A 2 2
MIRT542924 HOXC8 homeobox C8 2 2
MIRT544580 AP5Z1 adaptor related protein complex 5 zeta 1 subunit 2 4
MIRT545175 RFTN2 raftlin family member 2 2 2
MIRT545248 GTF2E1 general transcription factor IIE subunit 1 2 2
MIRT546473 SLC1A5 solute carrier family 1 member 5 2 2
MIRT547523 MARCH9 membrane associated ring-CH-type finger 9 2 2
MIRT548071 GIGYF1 GRB10 interacting GYF protein 1 2 2
MIRT548200 FNIP1 folliculin interacting protein 1 2 2
MIRT551216 CIDEC cell death inducing DFFA like effector c 2 2
MIRT553046 USP28 ubiquitin specific peptidase 28 2 2
MIRT553875 SUPT7L SPT7 like, STAGA complex gamma subunit 2 4
MIRT554026 SPCS3 signal peptidase complex subunit 3 2 2
MIRT554153 SLX4 SLX4 structure-specific endonuclease subunit 2 2
MIRT554192 SLC35E2B solute carrier family 35 member E2B 2 2
MIRT554362 SFXN5 sideroflexin 5 2 4
MIRT555349 PPP1R37 protein phosphatase 1 regulatory subunit 37 2 2
MIRT555822 PAX9 paired box 9 2 2
MIRT555866 PAIP1 poly(A) binding protein interacting protein 1 2 2
MIRT555931 NUP43 nucleoporin 43 2 2
MIRT555993 NFYB nuclear transcription factor Y subunit beta 2 2
MIRT556429 LONRF3 LON peptidase N-terminal domain and ring finger 3 2 2
MIRT556582 LHFPL2 LHFPL tetraspan subfamily member 2 2 4
MIRT557220 HNRNPDL heterogeneous nuclear ribonucleoprotein D like 2 2
MIRT558490 DBN1 drebrin 1 2 2
MIRT560986 GPBP1L1 GC-rich promoter binding protein 1 like 1 2 2
MIRT562291 GLO1 glyoxalase I 2 2
MIRT564093 TLR3 toll like receptor 3 2 2
MIRT565312 TMEM41A transmembrane protein 41A 2 2
MIRT565424 TEF TEF, PAR bZIP transcription factor 2 2
MIRT566946 LIMCH1 LIM and calponin homology domains 1 2 2
MIRT572369 ATOX1 antioxidant 1 copper chaperone 2 2
MIRT686211 ZNF267 zinc finger protein 267 2 2
MIRT686935 SFT2D3 SFT2 domain containing 3 2 2
MIRT687448 NR3C1 nuclear receptor subfamily 3 group C member 1 2 2
MIRT710856 COQ7 coenzyme Q7, hydroxylase 2 2
MIRT719484 RBM27 RNA binding motif protein 27 2 2
MIRT719813 TXNDC17 thioredoxin domain containing 17 2 2
MIRT720076 YTHDF3 YTH N6-methyladenosine RNA binding protein 3 2 2
MIRT723920 ADAMTS15 ADAM metallopeptidase with thrombospondin type 1 motif 15 2 2
MIRT731305 CUL4A cullin 4A 3 1
MIRT732128 BMP7 bone morphogenetic protein 7 2 1
MIRT732466 EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 3 0
MIRT732962 TNC tenascin C 1 0
MIRT734856 KDM4A lysine demethylase 4A 3 0
MIRT735625 MEF2A myocyte enhancer factor 2A 2 0
MIRT735795 IL6 interleukin 6 3 0
MIRT736333 DELE1 KIAA0141 2 0
MIRT736610 RUNX2 runt related transcription factor 2 3 0
MIRT736830 NOTCH1 notch 1 3 0
MIRT736888 KCNA2 potassium voltage-gated channel subfamily A member 2 3 0
MIRT737349 EGFR epidermal growth factor receptor 3 0
MIRT755368 GLS glutaminase 2 1
MIRT755431 SPHK2 sphingosine kinase 2 3 1
MIRT756119 USP30 ubiquitin specific peptidase 30 4 1
MIRT756144 XIAP X-linked inhibitor of apoptosis 3 1
MIRT756170 COL5A1 collagen type V alpha 1 chain 3 1
MIRT756171 FSTL1 follistatin like 1 3 1
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-137 Curcumin NULL 969516 Microarray apoE−/− mice 22253797 2012 down-regulated
miR-137 Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) NULL 8490 Microarray mouse brain 19270793 2009 down-regulated
miR-137 Emodin NULL 3220 Microarray K562 cells 23744534 2013 down-regualted
miR-137 Emodin NULL 3220 Quantitative real-time PCR K562 cells 23744534 2013 down-regualted
miR-137 Olea europaea leaf extract NULL NULL Quantitative real-time PCR Glioblastoma multiforme tumors cell lines 25232498 2014 up-regualted
miR-137 Formaldehyde NULL 712 Microarray Human lung epithelial cells (A549) 21147603 2011 down-regulated
miR-137 Ginsenoside Rh2 NULL 119307 Microarray human glioma cells U251 21372826 2011 up-regulated
miR-137 Interleukin 13 (IL-13) NULL NULL Quantitative real-time PCR esophageal squamous cells 22453679 2012 up-regulated
miR-137 1,2,6-Tri-O-galloyl-beta-D-glucopyranose NULL NULL Microarray HepG2 hepatocarcinoma cells. 22506400 2011 down-regulated
miR-137 5-Fluorouracil approved 3385 Microarray CNE cells 22614822 2012 up-regulated
miR-137 Olea europaea leaf extract NULL NULL Quantitative real-time PCR glioblastoma cells. 22722712 2012 up-regulated
miR-137 Temozolomide approved 5394 Quantitative real-time PCR glioblastoma cells. 22722712 2012 up-regulated
miR-137 Nicotine approved 89594 Microarray Rat adrenal pheochromocytoma PC12 cell 18845019 2009 up-regulated
miR-137 Capecitabine approved 60953 Quantitative real-time PCR rectal cancer 18695884 2008 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-137 Cisplatin 5460033 NSC119875 approved sensitive Low Breast Cancer cell line (MDA-MB-231)
hsa-mir-137 Ceritinib 57379345 NSC776422 approved resistant High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-mir-137 Paclitaxel 36314 NSC125973 approved sensitive cell line (W1)
hsa-mir-137 Cisplatin 5460033 NSC119875 approved sensitive cell line (W1)
hsa-mir-137 Doxorubicin 31703 NSC123127 approved sensitive cell line (W1)
hsa-mir-137 Topotecan 60699 NSC609699 approved resistant cell line (W1)

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