miRTarBase - #MIRT091394


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pre-miRNA Information
pre-miRNA hsa-mir-7849   
Genomic Coordinates chr4: 146408583 - 146408688
Description Homo sapiens miR-7849 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-7849-3p
Sequence 64| GACAAUUGUUGAUCUUGGGCCU |85
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1386078731 3 dbSNP
rs144001291 10 dbSNP
rs1334425573 16 dbSNP
rs557644637 20 dbSNP
Putative Targets

Gene Information
Gene Symbol EIF4A2   
Synonyms BM-010, DDX2B, EIF4A, EIF4F, eIF-4A-II, eIF4A-II
Description eukaryotic translation initiation factor 4A2
Transcript NM_001967   
Expression
Putative miRNA Targets on EIF4A2
3'UTR of EIF4A2
(miRNA target sites are highlighted)		 
>EIF4A2|NM_001967|3'UTR
   1 TTCCTGGGATGAGAGTTTTGGATGCAGTGCTCGCTGTTGCTGAATAGGCGATCACAACGTGCATTGTGCTTCTTTCTTTG
  81 GGAATATTTGAATCTTGTCTCAATGCTCATAACGGATCAGAAATACAGATTTTGATAGCAAAGCGACGTTAGTCGTGAGC
 161 TCTTGTGAGGAAAGTCATTGGCTTTATCCTCTTTAGAGTTAGACTGTTGGGGTGGGTATAAAAGATGGGGTCTGTAAAAT
 241 CTTTCTTTCTTAGAAATTTATTTCCTAGTTCTGTAGAAATGGTTGTATTAGATGTTCTCTATCATTTAATAATATACTTG
 321 TGGACTAAAAGATATAAGTGCTGTATAAAATCAGCCAATTATGTTAAACTAGCATATCTGCCTTTATTGTGTTTGTCATT
 401 AGCCTGAGTAGAAAGGCCTTTAAAATTTTTTTAGAAAGCATTTGAATGCATTTTGTTTGGTATTGTATTTATTCAATAAA
 481 GTATTTAATTAGTGCTAAGTGTGAACTGGACCCTGTTGCTAAGCCCCAGCAAGCAATCCTAGGTAGGGTTTAATCCCCAG
 561 TAAAATTGCCATATTGCACATGTCTTAATGAAGTTTGAATGTTAAATAAATTGTATATTCACTTTAAAAAAAAAAAAAAA
 641 AA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' uccgggUUCUAGUU--GUUAACAg 5'
                || :|:||   |||||| 
Target 5' agtttgAATGTTAAATAAATTGTa 3'
 592 - 615 122.00 -5.30
2 
miRNA  3' uccGGGUUCUAG------UUGUUAACAg 5'
             :|| || ||      ||:::|||| 
Target 5' attTCCTAGTTCTGTAGAAATGGTTGTa 3'
 260 - 287 109.00 -7.10
3 
miRNA  3' uccGGG---UUCUAGUUGU-UAACag 5'
             |||   || ||:: || ||||  
Target 5' atcCCCAGTAAAATTGCCATATTGca 3'
 553 - 578 107.00 -6.96
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN31578432 9 COSMIC
COSN23273021 11 COSMIC
COSN31529753 12 COSMIC
COSN30105285 43 COSMIC
COSN26974805 51 COSMIC
COSN31594903 58 COSMIC
COSN19663440 74 COSMIC
COSN30463046 81 COSMIC
COSN30495416 83 COSMIC
COSN29571273 84 COSMIC
COSN30491676 95 COSMIC
COSN31485689 104 COSMIC
COSN19662438 146 COSMIC
COSN31599551 155 COSMIC
COSN30120971 171 COSMIC
COSN19479342 199 COSMIC
COSN30140471 229 COSMIC
COSN30166917 292 COSMIC
COSN31522249 302 COSMIC
COSN31515830 332 COSMIC
COSN30176632 439 COSMIC
COSN31519268 491 COSMIC
COSN21328950 499 COSMIC
COSN27696823 505 COSMIC
COSN30165555 510 COSMIC
COSN31550761 540 COSMIC
COSN26576112 547 COSMIC
COSN31540186 560 COSMIC
COSN1936757 589 COSMIC
COSN4815318 593 COSMIC
COSN30123337 610 COSMIC
COSN31577805 612 COSMIC
COSN31561243 618 COSMIC
COSN28187968 621 COSMIC
rs140225704 72 GWAS
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs576252744 3 dbSNP
rs777313627 4 dbSNP
rs34652223 5 dbSNP
rs757081149 6 dbSNP
rs778652756 7 dbSNP
rs748275688 10 dbSNP
rs770116011 11 dbSNP
rs1319635845 13 dbSNP
rs1421648009 14 dbSNP
rs745861363 15 dbSNP
rs773586241 18 dbSNP
rs1429676396 19 dbSNP
rs758261570 20 dbSNP
rs779986953 22 dbSNP
rs762792787 23 dbSNP
rs1430907324 26 dbSNP
rs748201710 30 dbSNP
rs1475349057 32 dbSNP
rs371597681 33 dbSNP
rs749499275 34 dbSNP
rs1275159734 35 dbSNP
rs912449762 36 dbSNP
rs1482592335 39 dbSNP
rs1242598164 40 dbSNP
rs771481092 41 dbSNP
rs1326014249 42 dbSNP
rs977522915 43 dbSNP
rs1272347852 44 dbSNP
rs374862980 46 dbSNP
rs564710155 50 dbSNP
rs1218093303 51 dbSNP
rs767921628 52 dbSNP
rs1298963380 53 dbSNP
rs776013970 53 dbSNP
rs1437931839 54 dbSNP
rs1369188808 56 dbSNP
rs1424366887 56 dbSNP
rs1325660883 57 dbSNP
rs918688197 59 dbSNP
rs1351246881 64 dbSNP
rs931423852 65 dbSNP
rs1431285999 70 dbSNP
rs1170223927 71 dbSNP
rs140225704 72 dbSNP
rs1430682843 77 dbSNP
rs1307600304 79 dbSNP
rs1452504993 80 dbSNP
rs1352850477 82 dbSNP
rs1438621436 95 dbSNP
rs753529473 102 dbSNP
rs1248642829 104 dbSNP
rs1367505846 109 dbSNP
rs540748504 110 dbSNP
rs948024893 114 dbSNP
rs1046697968 115 dbSNP
rs906756760 121 dbSNP
rs1343254668 122 dbSNP
rs993255718 124 dbSNP
rs1387675136 125 dbSNP
rs1480880923 125 dbSNP
rs999703889 127 dbSNP
rs1296039301 130 dbSNP
rs1031619902 137 dbSNP
rs1221645031 145 dbSNP
rs893970467 146 dbSNP
rs887621882 147 dbSNP
rs758759080 148 dbSNP
rs758146089 149 dbSNP
rs1017960806 151 dbSNP
rs1011762644 155 dbSNP
rs977191168 161 dbSNP
rs777996203 163 dbSNP
rs953726443 165 dbSNP
rs1207370207 170 dbSNP
rs1484771631 178 dbSNP
rs985066892 179 dbSNP
rs1234629419 182 dbSNP
rs1314263887 183 dbSNP
rs1305308782 186 dbSNP
rs189228194 187 dbSNP
rs1417637497 188 dbSNP
rs1309540333 192 dbSNP
rs1350715504 192 dbSNP
rs775107524 193 dbSNP
rs1374374521 195 dbSNP
rs1165547747 197 dbSNP
rs1361783920 197 dbSNP
rs965640414 197 dbSNP
rs972669170 200 dbSNP
rs1439366348 201 dbSNP
rs1323067867 203 dbSNP
rs1184668682 204 dbSNP
rs1256934317 205 dbSNP
rs1474237267 205 dbSNP
rs926095586 207 dbSNP
rs957564153 209 dbSNP
rs1259542442 213 dbSNP
rs1215511638 215 dbSNP
rs1330289343 216 dbSNP
rs918456084 217 dbSNP
rs1354225538 221 dbSNP
rs1268107402 223 dbSNP
rs1312814793 231 dbSNP
rs1397657349 232 dbSNP
rs368637701 235 dbSNP
rs1201948770 238 dbSNP
rs1288288939 240 dbSNP
rs527890488 242 dbSNP
rs751725492 244 dbSNP
rs1288564002 245 dbSNP
rs949742163 246 dbSNP
rs984235697 249 dbSNP
rs191402072 252 dbSNP
rs1367903660 256 dbSNP
rs561673481 258 dbSNP
rs1046392753 260 dbSNP
rs1425702717 266 dbSNP
rs906524155 269 dbSNP
rs935619541 271 dbSNP
rs531893016 272 dbSNP
rs781403760 274 dbSNP
rs1210530401 280 dbSNP
rs1211364376 284 dbSNP
rs1268612579 285 dbSNP
rs1464328251 291 dbSNP
rs929009532 296 dbSNP
rs1246351233 298 dbSNP
rs1052681393 300 dbSNP
rs893992269 301 dbSNP
rs1294705848 318 dbSNP
rs183569905 321 dbSNP
rs1367005858 322 dbSNP
rs1323657289 329 dbSNP
rs1182629379 331 dbSNP
rs1010999986 332 dbSNP
rs1021348182 335 dbSNP
rs3917143 336 dbSNP
rs1390282835 342 dbSNP
rs1164089681 345 dbSNP
rs1006518563 351 dbSNP
rs1019273936 363 dbSNP
rs1168467322 366 dbSNP
rs1450644377 368 dbSNP
rs1250226965 369 dbSNP
rs188694026 370 dbSNP
rs1038942185 371 dbSNP
rs1451467164 372 dbSNP
rs547919546 373 dbSNP
rs780677802 375 dbSNP
rs901722096 379 dbSNP
rs965072736 381 dbSNP
rs1030053624 384 dbSNP
rs1228972235 384 dbSNP
rs1301245156 388 dbSNP
rs1390000395 388 dbSNP
rs577857192 389 dbSNP
rs1324390330 390 dbSNP
rs1388776079 391 dbSNP
rs372243469 393 dbSNP
rs1316638103 396 dbSNP
rs1025547173 399 dbSNP
rs1361219460 403 dbSNP
rs1448331944 406 dbSNP
rs952668622 406 dbSNP
rs983934442 407 dbSNP
rs1172362373 409 dbSNP
rs1283182598 409 dbSNP
rs1392565666 409 dbSNP
rs1353027473 410 dbSNP
rs967365723 411 dbSNP
rs998882901 412 dbSNP
rs1033081641 414 dbSNP
rs1435726207 415 dbSNP
rs111872989 416 dbSNP
rs566168880 418 dbSNP
rs1328369619 419 dbSNP
rs992103281 420 dbSNP
rs1278070998 422 dbSNP
rs1218597914 423 dbSNP
rs1203207095 426 dbSNP
rs1345406617 426 dbSNP
rs916091225 429 dbSNP
rs536496773 433 dbSNP
rs1307734478 438 dbSNP
rs1410487175 440 dbSNP
rs1372545237 443 dbSNP
rs375665300 444 dbSNP
rs1311543983 452 dbSNP
rs981728523 460 dbSNP
rs1403281109 461 dbSNP
rs1211090596 465 dbSNP
rs1468982129 467 dbSNP
rs918911170 470 dbSNP
rs1473257887 473 dbSNP
rs769083056 473 dbSNP
rs982187922 475 dbSNP
rs1209257439 477 dbSNP
rs927976901 477 dbSNP
rs1442949011 478 dbSNP
rs1280723435 479 dbSNP
rs1203156178 482 dbSNP
rs569577777 482 dbSNP
rs935330751 483 dbSNP
rs1474298656 485 dbSNP
rs1053129317 487 dbSNP
rs1184410225 489 dbSNP
rs943140662 491 dbSNP
rs915472813 494 dbSNP
rs1413397052 496 dbSNP
rs1447461565 499 dbSNP
rs543296807 499 dbSNP
rs1470100631 504 dbSNP
rs3206822 508 dbSNP
rs946887794 514 dbSNP
rs1050519190 516 dbSNP
rs997815500 517 dbSNP
rs1414947794 518 dbSNP
rs1803534 520 dbSNP
rs1239102773 521 dbSNP
rs903173196 521 dbSNP
rs1191000362 525 dbSNP
rs554445341 526 dbSNP
rs1415337307 529 dbSNP
rs1033050793 533 dbSNP
rs1209531788 535 dbSNP
rs1331464677 537 dbSNP
rs1288066973 543 dbSNP
rs1333171573 549 dbSNP
rs1227778443 550 dbSNP
rs1380041714 554 dbSNP
rs957419740 556 dbSNP
rs1433564451 558 dbSNP
rs1364835273 568 dbSNP
rs1321660207 569 dbSNP
rs1437799490 571 dbSNP
rs773001179 572 dbSNP
rs900864955 575 dbSNP
rs1405428014 577 dbSNP
rs1415364551 578 dbSNP
rs1166050845 580 dbSNP
rs1411181722 580 dbSNP
rs1248626742 585 dbSNP
rs563474181 587 dbSNP
rs1466998766 588 dbSNP
rs1245177578 589 dbSNP
rs993822824 590 dbSNP
rs1322362801 591 dbSNP
rs1349296636 592 dbSNP
rs1236822941 594 dbSNP
rs1342059406 595 dbSNP
rs1299082782 598 dbSNP
rs1231034234 603 dbSNP
rs1365994947 603 dbSNP
rs982082067 604 dbSNP
rs1345531219 606 dbSNP
rs1026603698 607 dbSNP
rs1351053588 608 dbSNP
rs1305623469 610 dbSNP
rs1279940754 611 dbSNP
rs1428617429 612 dbSNP
rs1390674779 614 dbSNP
rs1484795877 614 dbSNP
rs1207509690 616 dbSNP
rs1452285754 617 dbSNP
rs569967330 618 dbSNP
rs536963132 621 dbSNP
rs1203105751 626 dbSNP
rs1248734162 626 dbSNP
rs1482794335 626 dbSNP
rs952569387 627 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM545216. RNA binding protein: AGO2. Condition:miR-124 transfection ...

- Hafner M; Landthaler M; Burger L; Khorshid et al., 2010, Cell.

Article - Hafner M; Landthaler M; Burger L; Khorshid et al.
- Cell, 2010
RNA transcripts are subject to posttranscriptional gene regulation involving hundreds of RNA-binding proteins (RBPs) and microRNA-containing ribonucleoprotein complexes (miRNPs) expressed in a cell-type dependent fashion. We developed a cell-based crosslinking approach to determine at high resolution and transcriptome-wide the binding sites of cellular RBPs and miRNPs. The crosslinked sites are revealed by thymidine to cytidine transitions in the cDNAs prepared from immunopurified RNPs of 4-thiouridine-treated cells. We determined the binding sites and regulatory consequences for several intensely studied RBPs and miRNPs, including PUM2, QKI, IGF2BP1-3, AGO/EIF2C1-4 and TNRC6A-C. Our study revealed that these factors bind thousands of sites containing defined sequence motifs and have distinct preferences for exonic versus intronic or coding versus untranslated transcript regions. The precise mapping of binding sites across the transcriptome will be critical to the interpretation of the rapidly emerging data on genetic variation between individuals and how these variations contribute to complex genetic diseases.
LinkOut: [PMID: 20371350]
CLIP-seq Support 1 for dataset GSM545216
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / miR-124 transfection
Location of target site ENST00000323963.5 | 3UTR | UAAAUAAAUUGUAUAUUCACUUU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 20371350 / GSE21578
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
69 hsa-miR-7849-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT062192 WNK1 WNK lysine deficient protein kinase 1 2 2
MIRT064755 CCND2 cyclin D2 2 8
MIRT076594 NUFIP2 NUFIP2, FMR1 interacting protein 2 2 2
MIRT086027 UBR3 ubiquitin protein ligase E3 component n-recognin 3 (putative) 2 2
MIRT091394 EIF4A2 eukaryotic translation initiation factor 4A2 2 2
MIRT104730 KLF10 Kruppel like factor 10 2 2
MIRT105345 SLC7A2 solute carrier family 7 member 2 2 2
MIRT105672 PNMA2 paraneoplastic Ma antigen 2 2 6
MIRT173218 TMEM64 transmembrane protein 64 2 2
MIRT228305 SMU1 DNA replication regulator and spliceosomal factor 2 2
MIRT229503 EIF1AX eukaryotic translation initiation factor 1A, X-linked 2 2
MIRT243387 SKIL SKI like proto-oncogene 2 2
MIRT257404 E2F3 E2F transcription factor 3 2 2
MIRT301069 SLC16A14 solute carrier family 16 member 14 2 4
MIRT307327 CTNNB1 catenin beta 1 2 2
MIRT443182 DENND4C DENN domain containing 4C 2 2
MIRT469272 RHOB ras homolog family member B 2 8
MIRT475106 IRF2BP2 interferon regulatory factor 2 binding protein 2 2 4
MIRT484134 C14orf142 GON7, KEOPS complex subunit homolog 2 2
MIRT491117 TMTC1 transmembrane and tetratricopeptide repeat containing 1 2 4
MIRT504856 HAUS3 HAUS augmin like complex subunit 3 2 4
MIRT505544 SNX16 sorting nexin 16 2 6
MIRT506752 LCOR ligand dependent nuclear receptor corepressor 2 8
MIRT507358 FAM129A family with sequence similarity 129 member A 2 6
MIRT507812 CDK6 cyclin dependent kinase 6 2 6
MIRT510730 SON SON DNA binding protein 2 6
MIRT521296 RRAGD Ras related GTP binding D 2 4
MIRT521371 RNF11 ring finger protein 11 2 6
MIRT525860 ARL13B ADP ribosylation factor like GTPase 13B 2 2
MIRT527352 FAM69C family with sequence similarity 69 member C 2 2
MIRT528796 RAB32 RAB32, member RAS oncogene family 2 2
MIRT530417 SULT1B1 sulfotransferase family 1B member 1 2 2
MIRT533425 TWF1 twinfilin actin binding protein 1 2 2
MIRT539512 ACSS3 acyl-CoA synthetase short chain family member 3 2 2
MIRT543660 ZNF589 zinc finger protein 589 2 4
MIRT544833 ZNF639 zinc finger protein 639 2 2
MIRT545266 TRIM36 tripartite motif containing 36 2 4
MIRT545425 SLC39A6 solute carrier family 39 member 6 2 2
MIRT546070 VEZF1 vascular endothelial zinc finger 1 2 2
MIRT546896 PTPRK protein tyrosine phosphatase, receptor type K 2 2
MIRT547932 HNRNPR heterogeneous nuclear ribonucleoprotein R 2 2
MIRT548836 CHD1 chromodomain helicase DNA binding protein 1 2 4
MIRT550937 ZNF100 zinc finger protein 100 2 2
MIRT551840 AASDHPPT aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 2 2
MIRT553749 TBC1D8 TBC1 domain family member 8 2 2
MIRT554070 SOBP sine oculis binding protein homolog 2 2
MIRT554254 SIX4 SIX homeobox 4 2 2
MIRT558254 DYRK2 dual specificity tyrosine phosphorylation regulated kinase 2 2 2
MIRT559252 BBX BBX, HMG-box containing 2 4
MIRT561110 OPA3 OPA3, outer mitochondrial membrane lipid metabolism regulator 2 2
MIRT561412 TSN translin 2 2
MIRT562154 ID4 inhibitor of DNA binding 4, HLH protein 2 2
MIRT563324 ORC4 origin recognition complex subunit 4 2 2
MIRT563985 SLFN11 schlafen family member 11 2 2
MIRT571387 JKAMP JNK1/MAPK8-associated membrane protein 2 2
MIRT575040 Fasl Fas ligand (TNF superfamily, member 6) 1 1
MIRT610374 C9orf64 chromosome 9 open reading frame 64 2 2
MIRT611045 FASLG Fas ligand 2 3
MIRT625440 RMDN1 regulator of microtubule dynamics 1 2 2
MIRT655071 PKIA cAMP-dependent protein kinase inhibitor alpha 2 2
MIRT656139 MSH6 mutS homolog 6 2 2
MIRT667042 PDE3A phosphodiesterase 3A 2 2
MIRT691264 ICOSLG inducible T-cell costimulator ligand 2 2
MIRT699773 SEMA4D semaphorin 4D 2 2
MIRT707809 TSPAN6 tetraspanin 6 2 2
MIRT711125 CYYR1 cysteine and tyrosine rich 1 2 2
MIRT714107 RLIM ring finger protein, LIM domain interacting 2 2
MIRT717792 TGFBR2 transforming growth factor beta receptor 2 2 2
MIRT717929 ZNF546 zinc finger protein 546 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-7849-3p Imatinib 5291 NSC743414 approved sensitive High Chronic Myelogenous Leukemia tissue
hsa-miR-7849-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)

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