miRTarBase - #MIRT092735


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pre-miRNA Information
pre-miRNA hsa-mir-646   
Genomic Coordinates chr20: 60308474 - 60308567
Synonyms MIRN646, hsa-mir-646, MIR646
Description Homo sapiens miR-646 stem-loop
Comment None
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-646
Sequence 61| AAGCAGCUGCCUCUGAGGC |79
Evidence Experimental
Experiments SAGE
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs750684400 6 dbSNP
rs112880289 10 dbSNP
rs553679341 11 dbSNP
rs941692683 13 dbSNP
rs6513497 14 dbSNP
rs1431341059 18 dbSNP
rs1479355932 19 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol SETD5   
Synonyms -
Description SET domain containing 5
Transcript NM_001080517   
Expression
Putative miRNA Targets on SETD5
3'UTR of SETD5
(miRNA target sites are highlighted)		 
>SETD5|NM_001080517|3'UTR
   1 GGCTTCTGGATTTGGGCAAACAGAACTGAATGAGCCCATAGCTGCTTCCTTCCAGCTGCCTCTGGAACCTAGGCCGAGCA
  81 TATTGCTGAGGAACGGGGGGTACAAGGTGCCAGAGGATTGGGTCTGGTGGACAAGAAACAAGACTTGTGGTCACAATTGG
 161 CCTCTGGCCTTGGAGAAAGCTGTAAATCTTGTCTGAAGCAGAGACTATAAAGAAGTTTCTCCCTGCTGTCAAGGGTACAT
 241 TGTTGACAAGCAAATGGTGTTTCGGTTAGTAACGGTTCTAAGTGCAATGAGTTGTGTTGAAGCCTCCGTCTCCCATCCTT
 321 GCCTGTAGCCCGTAGTCACTTGTGCAGTGAGGACATCTTTTTAAATTTAAAAAAAAAAAAAAAAAAAGTTTTCAAAGGAA
 401 AAAAAGTTAAAAGAGCCAATCTCAAAGCCCCAAGCCATCTGAGTACTGTTAGGGTTTTATGCACTTAAGAAAAAAGGTAG
 481 GTATGTAAATGTTCATCCTAAGACAACCATTCCAAAAGCAGGTATCTGGCCAATGTGTGTCCACCAAGAATACTGTTTAT
 561 CTTTGTCTTAAGATCACCAAGAAATAGGCAAGGATAGTAAAGCTTGGAACCTGCACCAACTGGAGGGTGCCTGGCTCTTT
 641 GAAGAAAAGCTCATGGTCAGCTCTTGATTATTCGGGAGCAGATTATTTGAGTAGATTGTCTGAGCCTCCAACTGTTACCA
 721 TCCTACTCCCCCTTCCCAAGCTATTTCACAGCTCAGTAACCCATGAAGTAAGTAGACAAGAAAAGGAGGAATGAGACATG
 801 ATATAGGCCAATTGCATTGCTACTTACCAGCTTTTGGCAATAAATTTCATTAGGAAGGATACCGAGTGGTTTGGGAATGC
 881 TTCGAATTTTATTTTTTCTACTCCCAATTAATCAGGAGTTGATGATCCCATGAGCAGGACCGCCTCCATGATTGGGGAGC
 961 ATGCACTTGTGACTGCAGGGTAAGAGTGGGAAGATAGGTTTGTGGAGTGGCACCGACAGGACTGTGATTGTGTGTGGGCC
1041 TGCCCCACATTTCTCTGGGGGATGCTTATGTGAGAGTGGGCCCAGTGAAAGAGTTACCAAGCCACCCACACCCCTAACAC
1121 TGTTCTGGATGAGAGATGAGAGCAGACCGGCTTCTCCCCATCAGTGCATTGTGCCTGTTGTACACCCCTGGAGGAGCCCT
1201 GGAGCCAGCCCAGGTGGGGTACACAATCTTTTTAAATTCCATATGGTTGCCAGCTTATTTCTTTCACTTGTTTACTGTAA
1281 TATCTGGCGTGTTTTTATTTATCTAATTTTGTATTCAGTTATAACCATGGTAGGGGTAGTGAATATATGACAGGTGTAAT
1361 CCCTGGTGCTGCAGTGGACCTTCTTTTCTTTTGGACAAGATAATACTGTGAGTTTCCCTCCTTCCTTCCCTCTAATTTGT
1441 TTTCCTTTTTTCCCCAGCCTCTTGCATCCCCTTCTTTTCTACCCTGTCCTACAACTATCATATGCACAGTCTTCTCTCTT
1521 TGTGTGTGACTGTTACAAAATTTCACTTTTCAAAATCGAAATCAGGTGTTTGCTCAAATGAGGGGAGATTTTTTTTTTTT
1601 TTTTTTTTTTAAATGCTGAGACCTCAGCAGAGTACTTTTCTTTTTGTTGTTTCCCCCACAAACCCATCAGTCTGGGAGAG
1681 CATTGGGAGTGGAAATCATGTTGCCTGGGATGCTGGTTTCTTTGTATATTATATAAAACGTATGTAAATGTCTCTCCATT
1761 TGGGCTGGGGTTTGCATTCTCCCCTTGGCTATTTAACCAAGGGGAGAGGCCAGCGGGCAGGCGGCCCTCACCCTGCCTGG
1841 CACGTGCAGAGACCCCAGCCACTCTGTGTGGGCAGGGTGCTGTCAAGACCAGACCTCTTGGGGGGGTAGGGGCGGGGGGG
1921 TGGGGGGAACTCTTGGAAGGGAAGAAGTATCACTTCTTTCTCAAGTGGAGTGTTTACACCTTGCTGTAACATTTGAACTT
2001 TCACAAGAGATGTAATAATTTTGATAATAAAATTCTTAACCATAATAATCATAAAGTTGAGAAAAAAAAAAAAAAAAAAA
2081 AAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' cgGAGU--CUCCG---UCGACGAa 5'
            || |  ||| |   ||||||| 
Target 5' aaCTGAATGAGCCCATAGCTGCTt 3'
 24 - 47 147.00 -14.70
2 
miRNA  3' cgGAGUCUCCGUCGACGaa 5'
            ||::|||  |||||:  
Target 5' gcCTTGGAGAAAGCTGTaa 3'
 167 - 185 125.00 -18.00
3 
miRNA  3' cgGAGUCUCCGUCGACGAa 5'
            |||| :| ||||| :| 
Target 5' agCTCATGGTCAGCTCTTg 3'
 648 - 666 117.00 -13.80
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
1205727 332 ClinVar
COSM8235341 1 COSMIC
COSN14083423 13 COSMIC
COSN14083424 23 COSMIC
COSN31525762 24 COSMIC
COSN31579576 36 COSMIC
COSN30509084 40 COSMIC
COSN30737636 57 COSMIC
COSN7717943 117 COSMIC
COSN20074791 158 COSMIC
COSN20090763 167 COSMIC
COSN16248510 208 COSMIC
COSN31534377 324 COSMIC
COSN20098083 388 COSMIC
COSN26573578 470 COSMIC
COSN31530312 885 COSMIC
COSN28767360 1033 COSMIC
COSN31562037 1149 COSMIC
COSN21091192 1163 COSMIC
COSN31608267 1262 COSMIC
COSN31520668 1276 COSMIC
COSN26635351 1312 COSMIC
COSN15842899 1380 COSMIC
COSN30173223 1564 COSMIC
COSN31529298 1588 COSMIC
COSN26671765 1641 COSMIC
COSN7717954 1665 COSMIC
COSN31607990 1681 COSMIC
COSN6784880 1739 COSMIC
COSN31479518 2024 COSMIC
COSN1972796 2054 COSMIC
rs2279440 737 GWAS
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1329713055 9 dbSNP
rs1474698023 11 dbSNP
rs770483513 16 dbSNP
rs773789004 20 dbSNP
rs761939358 22 dbSNP
rs929175073 22 dbSNP
rs550369785 23 dbSNP
rs1214819415 28 dbSNP
rs377088655 29 dbSNP
rs1385659623 32 dbSNP
rs1006148417 33 dbSNP
rs1292760205 33 dbSNP
rs1441972515 37 dbSNP
rs775260332 38 dbSNP
rs369475282 42 dbSNP
rs1264897533 47 dbSNP
rs1228094788 48 dbSNP
rs1328074257 65 dbSNP
rs1276078877 74 dbSNP
rs1382862728 75 dbSNP
rs750636537 76 dbSNP
rs756459872 77 dbSNP
rs1422315451 84 dbSNP
rs868476727 88 dbSNP
rs977041496 92 dbSNP
rs1038784995 94 dbSNP
rs1167931292 95 dbSNP
rs562194227 95 dbSNP
rs529596973 96 dbSNP
rs1477687957 98 dbSNP
rs146711037 99 dbSNP
rs1450036067 100 dbSNP
rs574639643 101 dbSNP
rs1341472048 103 dbSNP
rs985209105 103 dbSNP
rs1256068756 104 dbSNP
rs1456637594 104 dbSNP
rs1217826363 105 dbSNP
rs1284901325 106 dbSNP
rs565669026 108 dbSNP
rs766721714 113 dbSNP
rs891465326 119 dbSNP
rs192905198 120 dbSNP
rs1392611645 125 dbSNP
rs1403145720 131 dbSNP
rs1010224544 134 dbSNP
rs1430456464 136 dbSNP
rs1186127024 145 dbSNP
rs561566665 145 dbSNP
rs754344270 146 dbSNP
rs551047652 157 dbSNP
rs1246345930 158 dbSNP
rs1475993773 163 dbSNP
rs569430092 167 dbSNP
rs1182699673 173 dbSNP
rs184678645 174 dbSNP
rs1421882950 176 dbSNP
rs1236386200 193 dbSNP
rs777323321 194 dbSNP
rs1197954327 196 dbSNP
rs1463754229 199 dbSNP
rs1330234619 209 dbSNP
rs1461665145 210 dbSNP
rs913110940 210 dbSNP
rs1406258939 211 dbSNP
rs1264774667 216 dbSNP
rs1428975353 218 dbSNP
rs1217260696 224 dbSNP
rs76610781 229 dbSNP
rs189465678 250 dbSNP
rs1331559497 258 dbSNP
rs1002354211 264 dbSNP
rs1045657575 265 dbSNP
rs1033821925 273 dbSNP
rs1315808886 274 dbSNP
rs573794988 275 dbSNP
rs1407401032 282 dbSNP
rs992205248 283 dbSNP
rs906519093 284 dbSNP
rs1413111362 288 dbSNP
rs1424791294 303 dbSNP
rs1263982154 306 dbSNP
rs1159395042 308 dbSNP
rs142730352 309 dbSNP
rs1378559282 311 dbSNP
rs1055189067 322 dbSNP
rs1461764654 323 dbSNP
rs888538804 330 dbSNP
rs11928554 332 dbSNP
rs1448110737 333 dbSNP
rs1284647715 335 dbSNP
rs1015769449 344 dbSNP
rs1196405970 345 dbSNP
rs1206550014 356 dbSNP
rs1350980361 359 dbSNP
rs770698236 366 dbSNP
rs779767477 366 dbSNP
rs62246322 367 dbSNP
rs1384260139 368 dbSNP
rs1491582899 368 dbSNP
rs1158183239 369 dbSNP
rs1358855217 369 dbSNP
rs1415925103 369 dbSNP
rs1445291903 369 dbSNP
rs1491513219 369 dbSNP
rs5846639 369 dbSNP
rs867499586 369 dbSNP
rs909156144 369 dbSNP
rs62964260 370 dbSNP
rs998425645 371 dbSNP
rs943170833 372 dbSNP
rs1487144301 376 dbSNP
rs1038860329 387 dbSNP
rs1170334185 389 dbSNP
rs1400818351 390 dbSNP
rs911067777 394 dbSNP
rs753011240 399 dbSNP
rs1360942208 400 dbSNP
rs1287064652 401 dbSNP
rs1227114996 402 dbSNP
rs1299925614 403 dbSNP
rs1396086501 406 dbSNP
rs1029943851 407 dbSNP
rs1402224991 408 dbSNP
rs1399147592 411 dbSNP
rs1283615464 412 dbSNP
rs953714441 417 dbSNP
rs1351710815 419 dbSNP
rs1162699452 424 dbSNP
rs1420137656 432 dbSNP
rs985543164 440 dbSNP
rs933020086 442 dbSNP
rs1262076214 443 dbSNP
rs1255511497 449 dbSNP
rs116540535 452 dbSNP
rs1219524526 457 dbSNP
rs546233346 460 dbSNP
rs1220177177 472 dbSNP
rs564541524 473 dbSNP
rs957349763 479 dbSNP
rs752156125 481 dbSNP
rs745472041 482 dbSNP
rs1044353091 484 dbSNP
rs1277909579 485 dbSNP
rs913058473 490 dbSNP
rs1269868508 501 dbSNP
rs1405796548 503 dbSNP
rs1434571174 506 dbSNP
rs949914291 507 dbSNP
rs1172698519 510 dbSNP
rs1463967355 519 dbSNP
rs1422667219 521 dbSNP
rs981303312 522 dbSNP
rs927218318 523 dbSNP
rs1196283576 529 dbSNP
rs1434610170 531 dbSNP
rs1376617415 534 dbSNP
rs1419768821 538 dbSNP
rs1480654910 545 dbSNP
rs1239425876 546 dbSNP
rs147980693 556 dbSNP
rs1160441092 562 dbSNP
rs1055540235 567 dbSNP
rs1358558733 568 dbSNP
rs1418949073 575 dbSNP
rs888495031 577 dbSNP
rs769523999 584 dbSNP
rs191204680 585 dbSNP
rs1037147302 588 dbSNP
rs897310152 593 dbSNP
rs1369400482 600 dbSNP
rs1218765729 607 dbSNP
rs1374193542 611 dbSNP
rs998373220 613 dbSNP
rs562301351 620 dbSNP
rs1399450173 628 dbSNP
rs1337211595 646 dbSNP
rs1013616960 653 dbSNP
rs1029885811 661 dbSNP
rs1174952898 666 dbSNP
rs1419250731 667 dbSNP
rs1381639245 670 dbSNP
rs74981768 674 dbSNP
rs1006517286 675 dbSNP
rs1238091240 680 dbSNP
rs950759275 682 dbSNP
rs576381521 699 dbSNP
rs984837854 701 dbSNP
rs775320962 712 dbSNP
rs988504924 715 dbSNP
rs1311638353 716 dbSNP
rs1238038607 720 dbSNP
rs548049653 721 dbSNP
rs1242424435 724 dbSNP
rs1020013620 727 dbSNP
rs1376128361 730 dbSNP
rs1283889818 732 dbSNP
rs141809438 733 dbSNP
rs1223820193 734 dbSNP
rs1267659761 736 dbSNP
rs2279440 737 dbSNP
rs1362059183 741 dbSNP
rs974661809 743 dbSNP
rs1189162185 747 dbSNP
rs1380271787 757 dbSNP
rs923068669 762 dbSNP
rs1426027163 764 dbSNP
rs927195658 769 dbSNP
rs1439860330 773 dbSNP
rs937254666 774 dbSNP
rs774368796 778 dbSNP
rs1179971574 783 dbSNP
rs1377904131 800 dbSNP
rs1214592930 805 dbSNP
rs1353113485 810 dbSNP
rs1266057353 812 dbSNP
rs984760734 815 dbSNP
rs1338561841 821 dbSNP
rs1311825470 825 dbSNP
rs532733025 827 dbSNP
rs1342044263 829 dbSNP
rs1295932975 830 dbSNP
rs913007181 836 dbSNP
rs947135716 839 dbSNP
rs1165365120 847 dbSNP
rs1164435746 849 dbSNP
rs1459954650 858 dbSNP
rs1367219099 860 dbSNP
rs1164571813 861 dbSNP
rs762018541 864 dbSNP
rs79402583 865 dbSNP
rs1268152275 866 dbSNP
rs777350114 870 dbSNP
rs934112818 873 dbSNP
rs150583070 884 dbSNP
rs1219054294 885 dbSNP
rs1319775086 885 dbSNP
rs773618963 886 dbSNP
rs1276017903 892 dbSNP
rs938230489 903 dbSNP
rs1055337101 907 dbSNP
rs1325014299 908 dbSNP
rs1384541879 916 dbSNP
rs1389250745 931 dbSNP
rs760921071 932 dbSNP
rs1456188057 940 dbSNP
rs558257432 942 dbSNP
rs1007544650 943 dbSNP
rs1426249341 945 dbSNP
rs1054742587 950 dbSNP
rs772490137 954 dbSNP
rs576781241 958 dbSNP
rs1449227785 962 dbSNP
rs1307207715 977 dbSNP
rs540741668 979 dbSNP
rs1026803937 980 dbSNP
rs1201156446 982 dbSNP
rs1229437403 984 dbSNP
rs886497986 995 dbSNP
rs1199222919 998 dbSNP
rs1315435824 999 dbSNP
rs1320350705 1015 dbSNP
rs536759454 1016 dbSNP
rs754217220 1017 dbSNP
rs1345336074 1023 dbSNP
rs17081119 1033 dbSNP
rs1252179809 1041 dbSNP
rs971125285 1049 dbSNP
rs1016230306 1050 dbSNP
rs1309284110 1057 dbSNP
rs1448171729 1058 dbSNP
rs1002668004 1061 dbSNP
rs1200086556 1066 dbSNP
rs1235879589 1068 dbSNP
rs1456906957 1071 dbSNP
rs765737097 1078 dbSNP
rs567432262 1087 dbSNP
rs574228410 1088 dbSNP
rs1030275538 1113 dbSNP
rs909149893 1117 dbSNP
rs954512314 1126 dbSNP
rs988630435 1130 dbSNP
rs962674669 1136 dbSNP
rs972736980 1137 dbSNP
rs756780660 1149 dbSNP
rs139957215 1150 dbSNP
rs780656569 1155 dbSNP
rs1197819176 1157 dbSNP
rs918634598 1169 dbSNP
rs1442816909 1172 dbSNP
rs1280410851 1184 dbSNP
rs913074178 1195 dbSNP
rs1467429792 1198 dbSNP
rs1309437131 1206 dbSNP
rs1329528894 1219 dbSNP
rs1399737544 1228 dbSNP
rs934059899 1241 dbSNP
rs553196519 1242 dbSNP
rs745544730 1244 dbSNP
rs1341469677 1255 dbSNP
rs1377623903 1258 dbSNP
rs1336497420 1273 dbSNP
rs1412988643 1276 dbSNP
rs755783693 1289 dbSNP
rs571584641 1290 dbSNP
rs1279256337 1293 dbSNP
rs542792700 1294 dbSNP
rs561194565 1295 dbSNP
rs1220130466 1297 dbSNP
rs926953563 1305 dbSNP
rs937048761 1318 dbSNP
rs1055285391 1328 dbSNP
rs1473048656 1330 dbSNP
rs1436808511 1343 dbSNP
rs1185127275 1353 dbSNP
rs1441556392 1355 dbSNP
rs1286247532 1398 dbSNP
rs745609275 1399 dbSNP
rs539794900 1401 dbSNP
rs1284635162 1425 dbSNP
rs942904830 1429 dbSNP
rs1047868796 1431 dbSNP
rs1055090558 1432 dbSNP
rs1286380463 1444 dbSNP
rs1446267241 1447 dbSNP
rs893400136 1451 dbSNP
rs1482248894 1453 dbSNP
rs1299058341 1457 dbSNP
rs1006273867 1462 dbSNP
rs1358710604 1468 dbSNP
rs779766702 1472 dbSNP
rs1158407418 1473 dbSNP
rs1405941633 1482 dbSNP
rs1037826146 1484 dbSNP
rs1009821694 1485 dbSNP
rs749117288 1493 dbSNP
rs1263568365 1495 dbSNP
rs1478679446 1498 dbSNP
rs1261849097 1504 dbSNP
rs1221640819 1505 dbSNP
rs531876765 1505 dbSNP
rs1041364690 1507 dbSNP
rs1292625101 1510 dbSNP
rs866321526 1515 dbSNP
rs1168878380 1517 dbSNP
rs1334650730 1520 dbSNP
rs1279167032 1521 dbSNP
rs1220712740 1531 dbSNP
rs1423194935 1536 dbSNP
rs906913450 1537 dbSNP
rs1178357199 1538 dbSNP
rs900483176 1542 dbSNP
rs996205205 1546 dbSNP
rs1030349081 1547 dbSNP
rs954585532 1550 dbSNP
rs1010571508 1555 dbSNP
rs1003023845 1558 dbSNP
rs1034128168 1559 dbSNP
rs1418341896 1562 dbSNP
rs1191304083 1570 dbSNP
rs1489190997 1572 dbSNP
rs1244437276 1576 dbSNP
rs1212376044 1582 dbSNP
rs918525009 1587 dbSNP
rs1299310068 1588 dbSNP
rs958761513 1588 dbSNP
rs1219985843 1589 dbSNP
rs1259177433 1589 dbSNP
rs1273082259 1589 dbSNP
rs1316337881 1589 dbSNP
rs1333193776 1589 dbSNP
rs1369857190 1589 dbSNP
rs1400922680 1589 dbSNP
rs1440096464 1589 dbSNP
rs1463834365 1589 dbSNP
rs58994037 1589 dbSNP
rs764550942 1589 dbSNP
rs968990818 1593 dbSNP
rs558189001 1598 dbSNP
rs1006067588 1605 dbSNP
rs1176380333 1609 dbSNP
rs1016155492 1611 dbSNP
rs1422466172 1611 dbSNP
rs1454275660 1611 dbSNP
rs1342849458 1612 dbSNP
rs978532076 1613 dbSNP
rs1277892122 1614 dbSNP
rs1338380512 1615 dbSNP
rs1479875579 1618 dbSNP
rs927070029 1623 dbSNP
rs1280192506 1635 dbSNP
rs1309906363 1636 dbSNP
rs929839310 1641 dbSNP
rs550073941 1647 dbSNP
rs1276656932 1650 dbSNP
rs961957537 1653 dbSNP
rs1489195641 1654 dbSNP
rs1311335297 1657 dbSNP
rs1444434853 1658 dbSNP
rs992426166 1664 dbSNP
rs972014612 1666 dbSNP
rs918582148 1667 dbSNP
rs1467314291 1681 dbSNP
rs916933123 1684 dbSNP
rs949624472 1690 dbSNP
rs1419750636 1692 dbSNP
rs1381574527 1700 dbSNP
rs1181087279 1704 dbSNP
rs1417781123 1706 dbSNP
rs1048457881 1711 dbSNP
rs1250272358 1713 dbSNP
rs908030659 1714 dbSNP
rs1484396489 1717 dbSNP
rs1262147722 1727 dbSNP
rs955386104 1740 dbSNP
rs1354545020 1741 dbSNP
rs1047769550 1751 dbSNP
rs1423202196 1753 dbSNP
rs1316259643 1755 dbSNP
rs911326608 1757 dbSNP
rs1397530525 1765 dbSNP
rs1037774462 1769 dbSNP
rs576543991 1774 dbSNP
rs764125151 1777 dbSNP
rs1363013863 1778 dbSNP
rs543896801 1798 dbSNP
rs1400186944 1804 dbSNP
rs1361902985 1806 dbSNP
rs1054636023 1807 dbSNP
rs914783754 1808 dbSNP
rs1466379445 1812 dbSNP
rs555611242 1816 dbSNP
rs890459361 1819 dbSNP
rs1425897181 1820 dbSNP
rs1041981703 1823 dbSNP
rs1020660215 1825 dbSNP
rs927978987 1831 dbSNP
rs1436808161 1844 dbSNP
rs1276248890 1846 dbSNP
rs1203465645 1848 dbSNP
rs939472848 1853 dbSNP
rs1485526674 1866 dbSNP
rs1364951917 1898 dbSNP
rs1246839893 1900 dbSNP
rs1265938458 1900 dbSNP
rs988595233 1900 dbSNP
rs1000015198 1901 dbSNP
rs1034160627 1902 dbSNP
rs958425973 1903 dbSNP
rs1232951043 1907 dbSNP
rs1294650242 1908 dbSNP
rs1459841618 1908 dbSNP
rs1055198586 1909 dbSNP
rs1248368551 1909 dbSNP
rs992540942 1913 dbSNP
rs1379282573 1914 dbSNP
rs763232134 1914 dbSNP
rs7635794 1914 dbSNP
rs77085802 1915 dbSNP
rs77280788 1918 dbSNP
rs75718126 1919 dbSNP
rs1268097154 1920 dbSNP
rs1171415216 1922 dbSNP
rs867496023 1922 dbSNP
rs1272379454 1924 dbSNP
rs776738661 1926 dbSNP
rs916882257 1930 dbSNP
rs1268020089 1931 dbSNP
rs1283355355 1932 dbSNP
rs1451936641 1934 dbSNP
rs13085737 1935 dbSNP
rs1331207524 1935 dbSNP
rs1302693935 1944 dbSNP
rs951157812 1945 dbSNP
rs1325702870 1947 dbSNP
rs1466451116 1957 dbSNP
rs1402850004 1959 dbSNP
rs1166404769 1963 dbSNP
rs1458439842 1965 dbSNP
rs1378290820 1966 dbSNP
rs13085756 1972 dbSNP
rs13085758 1975 dbSNP
rs983721357 1978 dbSNP
rs1245186153 1991 dbSNP
rs1453940409 1994 dbSNP
rs906861192 2002 dbSNP
rs1179072227 2013 dbSNP
rs1458940363 2035 dbSNP
rs1270569355 2042 dbSNP
rs942307101 2046 dbSNP
rs973542452 2061 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Disease 55209.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM714644. RNA binding protein: AGO2. Condition:completeT1 ...

- Kishore S; Jaskiewicz L; Burger L; Hausser et al., 2011, Nature methods.

Article - Kishore S; Jaskiewicz L; Burger L; Hausser et al.
- Nature methods, 2011
Cross-linking and immunoprecipitation (CLIP) is increasingly used to map transcriptome-wide binding sites of RNA-binding proteins. We developed a method for CLIP data analysis, and applied it to compare CLIP with photoactivatable ribonucleoside-enhanced CLIP (PAR-CLIP) and to uncover how differences in cross-linking and ribonuclease digestion affect the identified sites. We found only small differences in accuracies of these methods in identifying binding sites of HuR, which binds low-complexity sequences, and Argonaute 2, which has a complex binding specificity. We found that cross-link-induced mutations led to single-nucleotide resolution for both PAR-CLIP and CLIP. Our results confirm the expectation from original CLIP publications that RNA-binding proteins do not protect their binding sites sufficiently under the denaturing conditions used during the CLIP procedure, and we show that extensive digestion with sequence-specific RNases strongly biases the recovered binding sites. This bias can be substantially reduced by milder nuclease digestion conditions.
LinkOut: [PMID: 21572407]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions TZM-bl
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM1462574. RNA binding protein: AGO2. Condition:TZM-bl ami BaL ...

- Whisnant AW; Bogerd HP; Flores O; Ho P; et al., 2013, mBio.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' cggagucuccGUCGACGAa 5'
                    :||||||| 
Target 5' ----agcccaUAGCUGCUu 3'
 		1 - 15
2 
miRNA  3' cggagucuccGUCGAC-GAA---- 5'
                    |||||| ||     
Target 5' ugcuuccuucCAGCUGCCUCUGGA 3'
 		11 - 34
Article - Whisnant AW; Bogerd HP; Flores O; Ho P; et al.
- mBio, 2013
UNLABELLED: The question of how HIV-1 interfaces with cellular microRNA (miRNA) biogenesis and effector mechanisms has been highly controversial. Here, we first used deep sequencing of small RNAs present in two different infected cell lines (TZM-bl and C8166) and two types of primary human cells (CD4(+) peripheral blood mononuclear cells [PBMCs] and macrophages) to unequivocally demonstrate that HIV-1 does not encode any viral miRNAs. Perhaps surprisingly, we also observed that infection of T cells by HIV-1 has only a modest effect on the expression of cellular miRNAs at early times after infection. Comprehensive analysis of miRNA binding to the HIV-1 genome using the photoactivatable ribonucleoside-induced cross-linking and immunoprecipitation (PAR-CLIP) technique revealed several binding sites for cellular miRNAs, a subset of which were shown to be capable of mediating miRNA-mediated repression of gene expression. However, the main finding from this analysis is that HIV-1 transcripts are largely refractory to miRNA binding, most probably due to extensive viral RNA secondary structure. Together, these data demonstrate that HIV-1 neither encodes viral miRNAs nor strongly influences cellular miRNA expression, at least early after infection, and imply that HIV-1 transcripts have evolved to avoid inhibition by preexisting cellular miRNAs by adopting extensive RNA secondary structures that occlude most potential miRNA binding sites. IMPORTANCE: MicroRNAs (miRNAs) are a ubiquitous class of small regulatory RNAs that serve as posttranscriptional regulators of gene expression. Previous work has suggested that HIV-1 might subvert the function of the cellular miRNA machinery by expressing viral miRNAs or by dramatically altering the level of cellular miRNA expression. Using very sensitive approaches, we now demonstrate that neither of these ideas is in fact correct. Moreover, HIV-1 transcripts appear to largely avoid regulation by cellular miRNAs by adopting an extensive RNA secondary structure that occludes the ability of cellular miRNAs to interact with viral mRNAs. Together, these data suggest that HIV-1, rather than seeking to control miRNA function in infected cells, has instead evolved a mechanism to become largely invisible to cellular miRNA effector mechanisms.
LinkOut: [PMID: 23592263]
CLIP-seq Support 1 for dataset GSM4903825
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / PID14_NS
Location of target site NM_001080517 | 3UTR | GAAUGAGCCCAUAGCUGCUUCCUUCCAGCUGCCUCUGGAACCUAGGCCGAGCAUAUUGCUGAGGAACGGGGGGUACAAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161237
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM4903833
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_a
Location of target site NM_001080517 | 3UTR | GAAUGAGCCCAUAGCUGCUUCCUUCCAGCUGCCUCUGGAACCUAGGCCGAGCAUAUUGCUGAGGAACGGGGGGUACAAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM4903834
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_b
Location of target site NM_001080517 | 3UTR | AUAGCUGCUUCCUUCCAGCUGCCUCUGGAACCUAGGCCGAGCAUAUUGCUGAGGAACGGGGGGUACAAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 4 for dataset GSM4903835
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_c
Location of target site NM_001080517 | 3UTR | CCAUAGCUGCUUCCUUCCAGCUGCCUCUGGAACCUAGGCCGAGCAUAUUGCUGAGGAACGGGGGGUACAAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 5 for dataset GSM4903836
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / 124_TD_21_a
Location of target site NM_001080517 | 3UTR | GAGCCCAUAGCUGCUUCCUUCCAGCUGCCUCUGGAACCUAGGCCGAGCAUAUUGCUGAGGAACGGGGGGUACAAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 6 for dataset GSM4903837
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / 124_TD_21_b
Location of target site NM_001080517 | 3UTR | GCCCAUAGCUGCUUCCUUCCAGCUGCCUCUGGAACCUAGGCCGAGCAUAUUGCUGAGGAACGGGGGGUACAAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 7 for dataset GSM4903838
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / 124_TD_21_c
Location of target site NM_001080517 | 3UTR | GAAUGAGCCCAUAGCUGCUUCCUUCCAGCUGCCUCUGGAACCUAGGCCGAGCAUAUUGCUGAGGAACGGGGGGUACAAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 8 for dataset GSM714644
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / completeT1, repA
Location of target site ENST00000402198.1 | 3UTR | AAUGAGCCCAUAGCUGCUUCCUUCCAGCUGCCUCUGGAACCUAGGCCGAGCAUAUUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 21572407 / GSE28865
CLIP-seq Viewer Link
CLIP-seq Support 9 for dataset GSM1462574
Method / RBP PAR-CLIP / AGO2
Cell line / Condition TZM-bl / TZM-bl ami BaL
Location of target site ENST00000402198.1 | 3UTR | AGCCCAUAGCUGCUUCCUUCCAGCUGCCUCUGGAACCU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23592263 / GSE59944
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE28260 Renal cortex and medulla 0.826 2.5e-4 0.615 1.3e-2 13 Click to see details
GSE17306 Multiple myeloma 0.228 5.8e-2 0.525 5.4e-5 49 Click to see details
GSE21687 Ependynoma primary tumors -0.165 9.6e-2 -0.190 6.6e-2 64 Click to see details
GSE26953 Aortic valvular endothelial cells -0.228 1.4e-1 -0.162 2.2e-1 24 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis -0.207 1.9e-1 -0.039 4.4e-1 20 Click to see details
GSE21849 B cell lymphoma -0.146 2.2e-1 0.287 6.6e-2 29 Click to see details
GSE28544 Breast cancer 0.156 2.3e-1 0.254 1.2e-1 24 Click to see details
GSE42095 Differentiated embryonic stem cells 0.127 2.8e-1 0.246 1.3e-1 23 Click to see details
GSE32688 Pancreatic cancer -0.101 2.9e-1 -0.049 3.9e-1 32 Click to see details
GSE17498 Multiple myeloma 0.06 3.6e-1 0.139 2.0e-1 40 Click to see details
GSE38226 Liver fibrosis 0.038 4.4e-1 -0.039 4.3e-1 21 Click to see details
GSE38974 Chronic obstructive pulmonary disease -0.023 4.6e-1 -0.072 3.7e-1 25 Click to see details
GSE38974 Chronic obstructive pulmonary disease -0.023 4.6e-1 -0.072 3.7e-1 25 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
243 hsa-miR-646 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT061535 BTG2 BTG anti-proliferation factor 2 2 4
MIRT064692 CCND2 cyclin D2 2 4
MIRT068834 FNDC3A fibronectin type III domain containing 3A 2 10
MIRT079080 BIRC5 baculoviral IAP repeat containing 5 2 6
MIRT092735 SETD5 SET domain containing 5 2 4
MIRT093692 PI4K2B phosphatidylinositol 4-kinase type 2 beta 2 6
MIRT096244 CANX calnexin 2 2
MIRT096296 SQSTM1 sequestosome 1 2 4
MIRT098839 PCMT1 protein-L-isoaspartate (D-aspartate) O-methyltransferase 2 2
MIRT100229 PRR3 proline rich 3 2 4
MIRT156479 ATP5G3 ATP synthase, H+ transporting, mitochondrial Fo complex subunit C3 (subunit 9) 2 2
MIRT186378 PNRC2 proline rich nuclear receptor coactivator 2 2 2
MIRT196460 TAOK1 TAO kinase 1 2 2
MIRT211252 FGF2 fibroblast growth factor 2 2 2
MIRT215233 NPM1 nucleophosmin 1 2 4
MIRT215383 CREBRF CREB3 regulatory factor 2 2
MIRT224972 BAG4 BCL2 associated athanogene 4 2 4
MIRT235598 KIF3B kinesin family member 3B 2 2
MIRT249860 CHAC1 ChaC glutathione specific gamma-glutamylcyclotransferase 1 2 2
MIRT258407 FOXK1 forkhead box K1 2 2
MIRT269359 WEE1 WEE1 G2 checkpoint kinase 2 4
MIRT310455 REST RE1 silencing transcription factor 2 2
MIRT314057 PIK3R1 phosphoinositide-3-kinase regulatory subunit 1 2 8
MIRT322288 SLC39A14 solute carrier family 39 member 14 2 2
MIRT326311 OCRL OCRL, inositol polyphosphate-5-phosphatase 2 2
MIRT329703 SCD stearoyl-CoA desaturase 2 2
MIRT341278 PABPN1 poly(A) binding protein nuclear 1 2 3
MIRT403798 AKIRIN1 akirin 1 2 2
MIRT438549 NOB1 NIN1/PSMD8 binding protein 1 homolog 1 1
MIRT441908 SEPN1 selenoprotein N 2 2
MIRT444125 ZNRF3 zinc and ring finger 3 2 2
MIRT445458 EXT1 exostosin glycosyltransferase 1 2 4
MIRT446500 ASCC1 activating signal cointegrator 1 complex subunit 1 2 2
MIRT446538 GOLGA8B golgin A8 family member B 2 2
MIRT447770 DMRT2 doublesex and mab-3 related transcription factor 2 2 2
MIRT448438 TLL1 tolloid like 1 2 2
MIRT448768 GOLGA8A golgin A8 family member A 2 2
MIRT460749 SRP14 signal recognition particle 14 2 2
MIRT461556 ACTR3B ARP3 actin related protein 3 homolog B 2 2
MIRT463163 ZNF367 zinc finger protein 367 2 10
MIRT464234 VEGFA vascular endothelial growth factor A 5 12
MIRT464496 UCK2 uridine-cytidine kinase 2 2 2
MIRT465157 TSC22D2 TSC22 domain family member 2 2 2
MIRT466429 TFAP2A transcription factor AP-2 alpha 2 8
MIRT467395 SOCS5 suppressor of cytokine signaling 5 2 2
MIRT468672 SEC24A SEC24 homolog A, COPII coat complex component 2 4
MIRT469407 REL REL proto-oncogene, NF-kB subunit 2 6
MIRT470750 PNPLA6 patatin like phospholipase domain containing 6 2 2
MIRT471947 NR6A1 nuclear receptor subfamily 6 group A member 1 2 2
MIRT472468 NAPG NSF attachment protein gamma 2 12
MIRT474571 KLHDC3 kelch domain containing 3 2 2
MIRT477443 ELOVL5 ELOVL fatty acid elongase 5 2 2
MIRT480541 BZW1 basic leucine zipper and W2 domains 1 2 12
MIRT482110 AKT3 AKT serine/threonine kinase 3 2 4
MIRT485206 PRKAR2A protein kinase cAMP-dependent type II regulatory subunit alpha 2 8
MIRT492318 SETD1B SET domain containing 1B 2 4
MIRT497144 TAPBP TAP binding protein 2 2
MIRT498976 ORC4 origin recognition complex subunit 4 2 8
MIRT499112 SNRPB2 small nuclear ribonucleoprotein polypeptide B2 2 8
MIRT499448 ODF2L outer dense fiber of sperm tails 2 like 2 8
MIRT500089 L2HGDH L-2-hydroxyglutarate dehydrogenase 2 8
MIRT500317 ZNF622 zinc finger protein 622 2 8
MIRT500414 ZMAT3 zinc finger matrin-type 3 2 8
MIRT500572 USP53 ubiquitin specific peptidase 53 2 2
MIRT500596 UBN2 ubinuclein 2 2 10
MIRT500797 TLK1 tousled like kinase 1 2 8
MIRT500932 SRPR SRP receptor alpha subunit 2 6
MIRT500946 SREK1 splicing regulatory glutamic acid and lysine rich protein 1 2 8
MIRT501081 SMAD7 SMAD family member 7 2 8
MIRT501515 PPTC7 PTC7 protein phosphatase homolog 2 6
MIRT501879 MOB4 MOB family member 4, phocein 2 8
MIRT502195 HSPE1-MOB4 HSPE1-MOB4 readthrough 2 8
MIRT502630 DDX3X DEAD-box helicase 3, X-linked 2 8
MIRT502650 DCTN5 dynactin subunit 5 2 8
MIRT502914 CDCA4 cell division cycle associated 4 2 8
MIRT502938 CDC37L1 cell division cycle 37 like 1 2 8
MIRT502987 CCND1 cyclin D1 6 3
MIRT503181 AGO2 argonaute 2, RISC catalytic component 2 6
MIRT504532 ZNF620 zinc finger protein 620 2 6
MIRT504715 DLC1 DLC1 Rho GTPase activating protein 2 6
MIRT504967 ZNRF2 zinc and ring finger 2 2 2
MIRT505073 ZFHX4 zinc finger homeobox 4 2 6
MIRT505109 YTHDC1 YTH domain containing 1 2 6
MIRT505342 TMEM245 transmembrane protein 245 2 6
MIRT505389 TMEM100 transmembrane protein 100 2 2
MIRT505681 SESTD1 SEC14 and spectrin domain containing 1 2 6
MIRT506162 PLAG1 PLAG1 zinc finger 2 8
MIRT506185 PHKA1 phosphorylase kinase regulatory subunit alpha 1 2 6
MIRT506354 NUP50 nucleoporin 50 2 6
MIRT506480 MYO5A myosin VA 2 6
MIRT506833 KIF23 kinesin family member 23 2 6
MIRT507310 FEM1B fem-1 homolog B 2 4
MIRT507847 CCNE2 cyclin E2 2 6
MIRT508670 DIABLO diablo IAP-binding mitochondrial protein 2 4
MIRT509137 ZNF691 zinc finger protein 691 2 4
MIRT509686 ATAD5 ATPase family, AAA domain containing 5 2 4
MIRT512205 C1orf21 chromosome 1 open reading frame 21 2 6
MIRT518087 TRIM35 tripartite motif containing 35 2 2
MIRT518990 NNT nicotinamide nucleotide transhydrogenase 2 4
MIRT520964 SPRED1 sprouty related EVH1 domain containing 1 2 2
MIRT521049 SLC2A3 solute carrier family 2 member 3 2 4
MIRT521192 SBNO1 strawberry notch homolog 1 2 6
MIRT521619 PSAT1 phosphoserine aminotransferase 1 2 6
MIRT522770 LAMTOR1 late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 2 2
MIRT533754 TMEM184B transmembrane protein 184B 2 2
MIRT534131 SNTB2 syntrophin beta 2 2 4
MIRT537159 GID8 GID complex subunit 8 homolog 2 2
MIRT537812 EFNB2 ephrin B2 2 4
MIRT538108 DDX6 DEAD-box helicase 6 2 2
MIRT540839 GNAT1 G protein subunit alpha transducin 1 2 4
MIRT541019 WIPI2 WD repeat domain, phosphoinositide interacting 2 2 2
MIRT541145 PISD phosphatidylserine decarboxylase 2 2
MIRT541387 CDC42SE2 CDC42 small effector 2 2 2
MIRT541422 CBX4 chromobox 4 2 2
MIRT543521 PRSS21 protease, serine 21 2 2
MIRT543794 RALGAPB Ral GTPase activating protein non-catalytic beta subunit 2 4
MIRT543831 GSG1 germ cell associated 1 2 2
MIRT544961 UGT2B4 UDP glucuronosyltransferase family 2 member B4 2 2
MIRT545182 MAP4K2 mitogen-activated protein kinase kinase kinase kinase 2 2 4
MIRT545343 CCDC83 coiled-coil domain containing 83 2 2
MIRT545367 LIN7C lin-7 homolog C, crumbs cell polarity complex component 2 2
MIRT545656 SPARC secreted protein acidic and cysteine rich 2 2
MIRT545678 DECR1 2,4-dienoyl-CoA reductase 1 2 2
MIRT545938 ZBTB44 zinc finger and BTB domain containing 44 2 4
MIRT546107 USP48 ubiquitin specific peptidase 48 2 4
MIRT546603 SALL1 spalt like transcription factor 1 2 4
MIRT546628 RTN4 reticulon 4 2 2
MIRT547321 NPTN neuroplastin 2 2
MIRT547660 KPNA3 karyopherin subunit alpha 3 2 2
MIRT547994 HCFC2 host cell factor C2 2 4
MIRT548048 GOLIM4 golgi integral membrane protein 4 2 2
MIRT548098 GFPT1 glutamine--fructose-6-phosphate transaminase 1 2 4
MIRT548721 CRK CRK proto-oncogene, adaptor protein 2 2
MIRT548938 CDK17 cyclin dependent kinase 17 2 2
MIRT549071 CACUL1 CDK2 associated cullin domain 1 2 2
MIRT549272 ASH1L ASH1 like histone lysine methyltransferase 2 2
MIRT549438 ACTR2 ARP2 actin related protein 2 homolog 2 2
MIRT550462 OSCAR osteoclast associated, immunoglobulin-like receptor 2 4
MIRT550794 WARS2 tryptophanyl tRNA synthetase 2, mitochondrial 2 2
MIRT550819 FAM229B family with sequence similarity 229 member B 2 2
MIRT551537 EMB embigin 2 2
MIRT552031 DNAJC10 DnaJ heat shock protein family (Hsp40) member C10 2 2
MIRT552340 ZNF704 zinc finger protein 704 2 2
MIRT552444 ZNF449 zinc finger protein 449 2 2
MIRT553116 UBR3 ubiquitin protein ligase E3 component n-recognin 3 (putative) 2 2
MIRT553448 TOX4 TOX high mobility group box family member 4 2 2
MIRT553725 TBX18 T-box 18 2 2
MIRT553805 SZRD1 SUZ RNA binding domain containing 1 2 4
MIRT554696 RNF149 ring finger protein 149 2 2
MIRT554831 RECK reversion inducing cysteine rich protein with kazal motifs 2 2
MIRT555139 PTPRD protein tyrosine phosphatase, receptor type D 2 2
MIRT555269 PRDM4 PR/SET domain 4 2 2
MIRT555312 PPP2R5C protein phosphatase 2 regulatory subunit B'gamma 2 4
MIRT555558 PLEKHA1 pleckstrin homology domain containing A1 2 2
MIRT556379 LURAP1L leucine rich adaptor protein 1 like 2 2
MIRT556669 KMT2D lysine methyltransferase 2D 2 4
MIRT556853 KANK1 KN motif and ankyrin repeat domains 1 2 4
MIRT557476 GPR27 G protein-coupled receptor 27 2 4
MIRT558361 DMTF1 cyclin D binding myb like transcription factor 1 2 2
MIRT558385 DHX33 DEAH-box helicase 33 2 2
MIRT558502 CYP26B1 cytochrome P450 family 26 subfamily B member 1 2 4
MIRT558515 CTDSPL CTD small phosphatase like 2 4
MIRT558583 CREBL2 cAMP responsive element binding protein like 2 2 4
MIRT558641 CNNM2 cyclin and CBS domain divalent metal cation transport mediator 2 2 2
MIRT558653 CNKSR3 CNKSR family member 3 2 2
MIRT558865 CD2AP CD2 associated protein 2 2
MIRT558888 CCNE1 cyclin E1 2 4
MIRT559002 CA8 carbonic anhydrase 8 2 2
MIRT559149 BTN3A3 butyrophilin subfamily 3 member A3 2 2
MIRT559999 RAB3IP RAB3A interacting protein 2 2
MIRT562023 LANCL1 LanC like 1 2 2
MIRT562474 CNOT6L CCR4-NOT transcription complex subunit 6 like 2 2
MIRT562586 CBX2 chromobox 2 2 2
MIRT562595 CAPZA2 capping actin protein of muscle Z-line alpha subunit 2 2 2
MIRT562873 KIAA1456 KIAA1456 2 2
MIRT562989 KIAA0408 KIAA0408 2 4
MIRT563082 SLC25A12 solute carrier family 25 member 12 2 2
MIRT563499 DLGAP3 DLG associated protein 3 2 2
MIRT563892 RAPH1 Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 2 2
MIRT564328 CCNT1 cyclin T1 2 2
MIRT564945 XKR7 XK related 7 2 2
MIRT564981 WNK3 WNK lysine deficient protein kinase 3 2 2
MIRT566302 PPM1A protein phosphatase, Mg2+/Mn2+ dependent 1A 2 2
MIRT566701 MTMR3 myotubularin related protein 3 2 2
MIRT566827 MAP3K7 mitogen-activated protein kinase kinase kinase 7 2 2
MIRT571236 SCAMP4 secretory carrier membrane protein 4 2 2
MIRT571424 RIF1 replication timing regulatory factor 1 2 2
MIRT571637 SKI SKI proto-oncogene 2 2
MIRT571836 NUFIP2 NUFIP2, FMR1 interacting protein 2 2 2
MIRT571962 KIF5B kinesin family member 5B 2 2
MIRT572104 DYNLL2 dynein light chain LC8-type 2 2 2
MIRT572183 CDK6 cyclin dependent kinase 6 2 2
MIRT572720 RBL1 RB transcriptional corepressor like 1 2 2
MIRT574589 N4BP1 NEDD4 binding protein 1 2 2
MIRT575878 Cask calcium/calmodulin-dependent serine protein kinase (MAGUK family) 2 3
MIRT609979 HERPUD2 HERPUD family member 2 2 2
MIRT612932 GPRIN3 GPRIN family member 3 2 2
MIRT614327 C1orf220 chromosome 1 open reading frame 220 2 2
MIRT614694 TRAK1 trafficking kinesin protein 1 2 2
MIRT618328 IPP intracisternal A particle-promoted polypeptide 2 2
MIRT618456 ZFP30 ZFP30 zinc finger protein 2 4
MIRT621135 EMC7 ER membrane protein complex subunit 7 2 4
MIRT622878 PDE12 phosphodiesterase 12 2 4
MIRT631163 CCBE1 collagen and calcium binding EGF domains 1 2 2
MIRT632793 KREMEN1 kringle containing transmembrane protein 1 2 2
MIRT636731 AFAP1 actin filament associated protein 1 2 2
MIRT649297 IRF8 interferon regulatory factor 8 2 2
MIRT650955 QPCTL glutaminyl-peptide cyclotransferase like 2 2
MIRT653267 SOGA3 SOGA family member 3 2 2
MIRT654665 PSMG1 proteasome assembly chaperone 1 2 2
MIRT656180 MPRIP myosin phosphatase Rho interacting protein 2 2
MIRT659252 CUL3 cullin 3 2 2
MIRT663826 NLRP12 NLR family pyrin domain containing 12 2 4
MIRT676632 CSNK1E casein kinase 1 epsilon 2 2
MIRT679503 ZNF106 zinc finger protein 106 2 2
MIRT680978 DCAF17 DDB1 and CUL4 associated factor 17 2 2
MIRT682272 RS1 retinoschisin 1 2 2
MIRT682421 OLR1 oxidized low density lipoprotein receptor 1 2 2
MIRT682510 GLP2R glucagon like peptide 2 receptor 2 2
MIRT693926 HNRNPA1L2 heterogeneous nuclear ribonucleoprotein A1-like 2 2 2
MIRT700660 PPP1R11 protein phosphatase 1 regulatory inhibitor subunit 11 2 2
MIRT700740 PLEKHA8 pleckstrin homology domain containing A8 2 2
MIRT702871 HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 2 2
MIRT703192 GPBP1 GC-rich promoter binding protein 1 2 2
MIRT704453 CSNK2A1 casein kinase 2 alpha 1 2 2
MIRT704709 CHEK1 checkpoint kinase 1 2 2
MIRT706164 CASK calcium/calmodulin dependent serine protein kinase 2 3
MIRT713334 DNAJC28 DnaJ heat shock protein family (Hsp40) member C28 2 2
MIRT713416 SLC35E2B solute carrier family 35 member E2B 2 2
MIRT716300 PAX1 paired box 1 2 2
MIRT717394 PTPRF protein tyrosine phosphatase, receptor type F 2 2
MIRT718453 BTNL9 butyrophilin like 9 2 2
MIRT718728 VWA9 integrator complex subunit 14 2 2
MIRT719029 SHROOM3 shroom family member 3 2 2
MIRT720367 ZBTB8B zinc finger and BTB domain containing 8B 2 2
MIRT723120 ZSCAN16 zinc finger and SCAN domain containing 16 2 2
MIRT733741 EGFR epidermal growth factor receptor 4 0
MIRT734281 HIF1A hypoxia inducible factor 1 alpha subunit 3 0
MIRT735934 EYA3 EYA transcriptional coactivator and phosphatase 3 3 0
MIRT755830 IGF1 insulin like growth factor 1 5 1
MIRT755831 BCL2 BCL2, apoptosis regulator 4 1
MIRT755832 CDK2 cyclin dependent kinase 2 4 1
MIRT755833 BAX BCL2 associated X, apoptosis regulator 4 1
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-646 Fluorouracil 3385 NSC19893 approved resistant cell line (OE19)
hsa-miR-646 Vemurafenib 42611257 NSC761431 approved sensitive cell line (LM16)
hsa-miR-646 Vemurafenib 42611257 NSC761431 approved sensitive cell line (LM43)
hsa-miR-646 Sunitinib 5329102 NSC750690 approved resistant tissue (CardB)
hsa-miR-646 Oxaliplatin 6857599 NSC266046 approved sensitive cell line (IGROV-1)
hsa-miR-646 Cisplatin 5460033 NSC119875 approved sensitive cell line (IGROV-1)
hsa-miR-646 Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-646 Cisplatin 5460033 NSC119875 approved sensitive cell line (H460)

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