miRTarBase - #MIRT093533


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pre-miRNA Information
pre-miRNA hsa-mir-367   
Genomic Coordinates chr4: 112647874 - 112647941
Synonyms MIRN367, hsa-mir-367, MIR367
Description Homo sapiens miR-367 stem-loop
Comment None
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-367-3p
Sequence 44| AAUUGCACUUUAGCAAUGGUGA |65
Evidence Experimental
Experiments Cloned
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSN24411246 17 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs535597757 1 dbSNP
rs1013348949 11 dbSNP
rs896333735 12 dbSNP
rs751269136 14 dbSNP
rs1163501507 16 dbSNP
rs757092597 21 dbSNP
Putative Targets

Gene Information
Gene Symbol GALNT7   
Synonyms GALNAC-T7, GalNAcT7
Description polypeptide N-acetylgalactosaminyltransferase 7
Transcript NM_017423   
Expression
Putative miRNA Targets on GALNT7
3'UTR of GALNT7
(miRNA target sites are highlighted)		 
>GALNT7|NM_017423|3'UTR
   1 AGAGAAAAAAATAAACCAATAACCTACCTACTGACAAGTAAATTTATACAGGACTGAAAACCGCCTGAAACCTGCTGCAA
  81 CTATTGTTATTAACTCTGTATAGCTCCAAACCTGGAACCTCCTGATCAGTTTGAAGGACATTGATAAACTGTGATTTTAC
 161 AATAACATTATCATCTGCAGTTACTGTTTACAAGACTGCTTTTACCTTAAACTTTGTAGATGTTTACATCTTTTTGTTGT
 241 GTTTTAAGATGATGTTGGTAATTTGTGCCTTTAGCTCTGTTTTATTAGACAGAGTTAAAGCATGTTGTCTTCTTTGGGAT
 321 TACACTCAGGGGTCTGAAAGGCAGTTTGATTTTTATTTTTAACACACTTGAAAAAAGGTTGGAGTAGCCAGACTTTCATA
 401 TATAACTTGGTGATTATCAACCTGTTGTGTCTTTATTTAATTTTACATCTTTTTGAAGCACTGCCACAGGTTATTAGCCA
 481 AGGTGGCCTTCCTTCACAGTCATGCTGCTTTTTTGAAAGGTGAATTTCAACACATTTAGTGCCTCTTTCATTTCTCAGTA
 561 TATATTTCAAGAGCTTGTGATGAAATCTATAGGATGGTAATGATGGACTTGTCACCTGTATGGGGAATACTTTTACTACT
 641 CAGAAATGAATTTATGTGCTGCCATTTGCTATAAAGTTGAACTTTGTATGGCTTGAAAAAGAAATGACAATATGGAACAT
 721 CCCAAGGCTGTCCCATAGGGTTGGAAGTTGTGTAGCATTCACTCCCTTACCTACTGGCATTCCCAGTGCCCTCTGTCCAT
 801 ACCTACTTCTAGGATTGCAAAGGAGTCTTCCAACTAGAGAAAAATTGTCCACTGACATTTGGGATTTACTTTTCTCCAAT
 881 ACCTGCCAATACAGAAAACTATTATCAGTTGTTATTGTTATCCCTTGAAAGCGAGGGTGACAAAAACAACAAAACACCGT
 961 TATAAACACATCAAAGGTTCATTCTGACTGAGGTAAGACTTTCCAAGCCCTTGTTAGATTAGGCCTTATAAAACTTGTGT
1041 GCATTATAACCTAAGCTGTGCAACCTGTGAAGCCAAGAGTGAACTGATGTTTCATTTATATTTTCATCCAAATGACATTA
1121 TCTGCACGTTTTTAAAATTTAAAAACAAAGGACTATTTAAAAATACAGTTTATTAACAAACGTGAACTACTTTCTGTTAC
1201 ATTAGGTGTTCCCTAGTGTTTCTTAATTTCTTTTTAGAAAGTGTATTTTTATTAGTATTTTTCCGGTGAACAGAAGATTT
1281 GTTTGGATTTAAACATTTACTAAGACAGTACCTATTAGGAAAACCAAATATTGCAAATGGTCAATTCGATTTTAATTTCT
1361 CAAAAGATACTCTGTTATCCAGAAGATTAAAATGCCTACATTGAGTGCTTAAAAAAAAAAAAACAACTGTGATGATGTGA
1441 GCAGAATGGCAAGTAAGTTAAGCATTTTTGATCCTGTAATCATGGTATCATTACAATGAAAGGAATTCACAAACTACTGC
1521 CAGAGGAAGTTTGTTTTTTAATTTAAGAGGGAAATATAACCTATAAATTTGTTTCTTCCAAGCTTAGCTCTTAAATTTGG
1601 AGACTCAAAGTTAAACATCCTCAACAGAGTTTTATTTATAATTTTGAATTGTCAATTTGTATTTTGCTACTGATCTGTGA
1681 TCAACCATTTTAACTTTCATCTCTAGGGATGTTTAACATTTATAATTGCAAAATAAACCAACTATAAAAAAAGAAACTAA
1761 GAGAGAATTGGTACTTTAATTACTTGTGTGTTTGCAAATAGGCTCCATTTTCCATGTTGAGTAGATTATAACCTTATTAA
1841 CTATGCATAGGCCTAAGAAAGGTGGCAATGAACTGTGCATGTAAATTTTAAATGGGTACTTTGTGCAATTCGTTAAAAGA
1921 AGATACTCTATGAATATGATTCTATATATTGAAATCAGAAAACCTACCAAACAAAAACATCAGAAGCTGCTGCCATAATG
2001 ACTATTTTCTACTGTAGGCTGCTTTGGAAATAATTCCCATATCCTTGCTTTGTAAGTTGGTAATATCACTATGCATTTCT
2081 ACACATTTTATAAATTTGATTTATGCAGATTTTGATACACTGTATGTTTCTGTAGAAATTGTATAAATATTCAAAATTTT
2161 ATTAGGATAAATTTGAGAAACTTACGTATATCTTAATTCTGGGTTGCTTGTTTTTTAGGTGACAAAAATAAAATATTGTA
2241 TTTTAATTCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' aguggUAACGAU--UUCACGUUAa 5'
               || | ||    ||||||| 
Target 5' tttaaATGGGTACTTTGTGCAATt 3'
 1887 - 1910 143.00 -9.10
2 
miRNA  3' agUGGUA-ACGAUUU--CACGUUaa 5'
            |::||   ||||:  ||||||  
Target 5' gcATTATAACCTAAGCTGTGCAAcc 3'
 1041 - 1065 134.00 -11.20
3 
miRNA  3' agugGUAAC--GA----UUUCA-CGUUAa 5'
              ||| |  ||    ||:|| ||||| 
Target 5' tatgCATAGGCCTAAGAAAGGTGGCAATg 3'
 1842 - 1870 122.00 -7.30
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30170336 3 COSMIC
COSN28866847 12 COSMIC
COSN30457432 18 COSMIC
COSN19657175 29 COSMIC
COSN30506851 30 COSMIC
COSN20075011 45 COSMIC
COSN14102551 64 COSMIC
COSN28185957 106 COSMIC
COSN30715037 108 COSMIC
COSN20075118 113 COSMIC
COSN30162780 120 COSMIC
COSN31480759 128 COSMIC
COSN24720747 150 COSMIC
COSN31585632 194 COSMIC
COSN30165650 516 COSMIC
COSN31526884 631 COSMIC
COSN16740958 852 COSMIC
COSN8374136 1042 COSMIC
COSN31609991 1386 COSMIC
COSN27420538 1424 COSMIC
COSN31515627 1504 COSMIC
COSN24424798 1567 COSMIC
COSN22505752 1691 COSMIC
COSN24300480 1712 COSMIC
COSN26671234 1903 COSMIC
COSN26573215 1912 COSMIC
COSN31538702 1912 COSMIC
COSN28692036 1943 COSMIC
COSN31480466 1959 COSMIC
COSN6814777 2068 COSMIC
COSN31528102 2094 COSMIC
COSN31562904 2186 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1005505657 4 dbSNP
rs1228930216 5 dbSNP
rs1409972965 5 dbSNP
rs1164725583 9 dbSNP
rs779436570 13 dbSNP
rs1427082471 14 dbSNP
rs35007233 16 dbSNP
rs746399267 17 dbSNP
rs771685808 18 dbSNP
rs183336314 20 dbSNP
rs959030914 28 dbSNP
rs757213717 29 dbSNP
rs1227763851 30 dbSNP
rs371601909 33 dbSNP
rs1350142596 34 dbSNP
rs373630379 36 dbSNP
rs1224607824 37 dbSNP
rs377469489 41 dbSNP
rs1292300905 47 dbSNP
rs761600369 48 dbSNP
rs1213218702 50 dbSNP
rs1039098647 63 dbSNP
rs901821956 64 dbSNP
rs1184929968 67 dbSNP
rs1240782974 71 dbSNP
rs997499841 79 dbSNP
rs1489642603 84 dbSNP
rs1247558644 91 dbSNP
rs977711146 95 dbSNP
rs1472173524 98 dbSNP
rs1158840431 99 dbSNP
rs1409627753 101 dbSNP
rs768741426 112 dbSNP
rs73872559 120 dbSNP
rs1281262953 122 dbSNP
rs1220764597 124 dbSNP
rs376076318 126 dbSNP
rs1269297352 134 dbSNP
rs935694202 140 dbSNP
rs1016810783 146 dbSNP
rs959569123 149 dbSNP
rs1390309057 150 dbSNP
rs1320639761 154 dbSNP
rs113077097 155 dbSNP
rs538919191 155 dbSNP
rs141053550 181 dbSNP
rs572267728 182 dbSNP
rs1174547387 200 dbSNP
rs910326344 206 dbSNP
rs1435318161 212 dbSNP
rs971040279 216 dbSNP
rs192584005 217 dbSNP
rs762164660 221 dbSNP
rs372990613 222 dbSNP
rs981128489 223 dbSNP
rs1447374801 228 dbSNP
rs1209478879 245 dbSNP
rs1460891431 267 dbSNP
rs150260684 271 dbSNP
rs901301412 282 dbSNP
rs1312614350 287 dbSNP
rs1221894541 293 dbSNP
rs1267210124 301 dbSNP
rs990094059 305 dbSNP
rs1366955248 319 dbSNP
rs1297810566 323 dbSNP
rs1451339829 324 dbSNP
rs1323967966 326 dbSNP
rs1301676498 333 dbSNP
rs1205553894 342 dbSNP
rs1360195035 346 dbSNP
rs1170194820 350 dbSNP
rs930246410 354 dbSNP
rs1428178591 361 dbSNP
rs765792472 370 dbSNP
rs1047339919 376 dbSNP
rs1189434304 380 dbSNP
rs1444131710 381 dbSNP
rs773653201 383 dbSNP
rs759051441 386 dbSNP
rs1483537308 387 dbSNP
rs1234283942 388 dbSNP
rs574828987 399 dbSNP
rs1468238439 401 dbSNP
rs1034296251 405 dbSNP
rs1202790338 407 dbSNP
rs894577680 410 dbSNP
rs1344010754 412 dbSNP
rs1274956919 413 dbSNP
rs943225336 432 dbSNP
rs1319464112 434 dbSNP
rs1314268502 440 dbSNP
rs138946471 444 dbSNP
rs149244596 445 dbSNP
rs1298062698 447 dbSNP
rs967579504 448 dbSNP
rs1372769802 459 dbSNP
rs1169540899 467 dbSNP
rs933319155 472 dbSNP
rs755839164 475 dbSNP
rs1032964387 478 dbSNP
rs1167037130 480 dbSNP
rs1413984395 495 dbSNP
rs1329580902 529 dbSNP
rs1048224356 549 dbSNP
rs1408290668 551 dbSNP
rs1287934627 563 dbSNP
rs1345972865 570 dbSNP
rs779972925 571 dbSNP
rs747148049 584 dbSNP
rs763620753 590 dbSNP
rs1266804832 592 dbSNP
rs957255024 596 dbSNP
rs532572089 597 dbSNP
rs910188916 601 dbSNP
rs545288303 607 dbSNP
rs1288317147 612 dbSNP
rs944478264 616 dbSNP
rs1227090736 626 dbSNP
rs753054112 635 dbSNP
rs1309020403 639 dbSNP
rs1016534043 647 dbSNP
rs1388869774 649 dbSNP
rs1295483170 655 dbSNP
rs1458510600 656 dbSNP
rs1363296171 657 dbSNP
rs976198210 672 dbSNP
rs1426627203 679 dbSNP
rs919011180 683 dbSNP
rs1012449853 685 dbSNP
rs1344163356 686 dbSNP
rs1022703411 707 dbSNP
rs930169182 711 dbSNP
rs565185377 727 dbSNP
rs1047204838 730 dbSNP
rs1204085786 736 dbSNP
rs753752399 738 dbSNP
rs888722429 740 dbSNP
rs981098902 753 dbSNP
rs73872561 763 dbSNP
rs3775590 764 dbSNP
rs990451474 771 dbSNP
rs184568522 772 dbSNP
rs1376468526 775 dbSNP
rs529735023 794 dbSNP
rs1329680084 796 dbSNP
rs894433866 800 dbSNP
rs1387551316 803 dbSNP
rs1014345534 813 dbSNP
rs1024852458 816 dbSNP
rs1389319538 822 dbSNP
rs903260355 824 dbSNP
rs577402778 826 dbSNP
rs745729823 838 dbSNP
rs923347510 845 dbSNP
rs1379153047 849 dbSNP
rs998718400 852 dbSNP
rs1427556993 861 dbSNP
rs146941910 863 dbSNP
rs1039327296 882 dbSNP
rs1245773524 890 dbSNP
rs1032820629 898 dbSNP
rs1406573863 902 dbSNP
rs1269364494 907 dbSNP
rs907843257 915 dbSNP
rs957285878 915 dbSNP
rs1330274203 916 dbSNP
rs1258145736 917 dbSNP
rs569279016 924 dbSNP
rs1364775006 934 dbSNP
rs142395216 942 dbSNP
rs1228115904 945 dbSNP
rs942054908 959 dbSNP
rs986008854 960 dbSNP
rs758577746 964 dbSNP
rs1333508760 976 dbSNP
rs1412676251 977 dbSNP
rs1404195770 978 dbSNP
rs1292060868 991 dbSNP
rs1038346716 996 dbSNP
rs895425355 1001 dbSNP
rs1387987039 1035 dbSNP
rs1017271698 1038 dbSNP
rs1170059157 1064 dbSNP
rs1449616194 1065 dbSNP
rs1241971455 1070 dbSNP
rs1184704098 1079 dbSNP
rs538259266 1080 dbSNP
rs1225219955 1085 dbSNP
rs1258826171 1085 dbSNP
rs1012418629 1090 dbSNP
rs1046635129 1094 dbSNP
rs1451367810 1105 dbSNP
rs137995292 1108 dbSNP
rs1002999828 1112 dbSNP
rs566030851 1123 dbSNP
rs919029544 1128 dbSNP
rs950453169 1129 dbSNP
rs982932255 1132 dbSNP
rs1342216784 1135 dbSNP
rs1334711771 1149 dbSNP
rs955871382 1153 dbSNP
rs1011263488 1155 dbSNP
rs1167992653 1157 dbSNP
rs1430015886 1165 dbSNP
rs143552054 1165 dbSNP
rs1412535989 1178 dbSNP
rs113852863 1181 dbSNP
rs575005075 1182 dbSNP
rs1370751688 1183 dbSNP
rs1188818109 1191 dbSNP
rs1291970352 1193 dbSNP
rs1389830427 1197 dbSNP
rs186474233 1198 dbSNP
rs1207671134 1213 dbSNP
rs974637849 1222 dbSNP
rs950129573 1265 dbSNP
rs192538227 1266 dbSNP
rs114139762 1268 dbSNP
rs1284774742 1272 dbSNP
rs1428294188 1283 dbSNP
rs1433755627 1286 dbSNP
rs1315082151 1288 dbSNP
rs1227695373 1295 dbSNP
rs1348491935 1302 dbSNP
rs546219303 1303 dbSNP
rs998909785 1307 dbSNP
rs1360952313 1308 dbSNP
rs112436840 1310 dbSNP
rs1054296335 1327 dbSNP
rs768992199 1342 dbSNP
rs1348966532 1348 dbSNP
rs184851635 1349 dbSNP
rs1406642866 1350 dbSNP
rs527573091 1362 dbSNP
rs770005917 1364 dbSNP
rs3839159 1368 dbSNP
rs397841437 1368 dbSNP
rs1250473925 1370 dbSNP
rs1410316165 1376 dbSNP
rs1184813038 1378 dbSNP
rs1463893832 1396 dbSNP
rs965975448 1402 dbSNP
rs11427838 1411 dbSNP
rs397828101 1411 dbSNP
rs565676151 1411 dbSNP
rs878880543 1411 dbSNP
rs997614837 1411 dbSNP
rs1208110625 1418 dbSNP
rs1025957548 1422 dbSNP
rs948252831 1422 dbSNP
rs1046687224 1424 dbSNP
rs1231459651 1425 dbSNP
rs906677163 1434 dbSNP
rs950485687 1435 dbSNP
rs758717740 1453 dbSNP
rs1438156245 1473 dbSNP
rs541348368 1480 dbSNP
rs962891350 1495 dbSNP
rs1331270218 1496 dbSNP
rs1319313577 1497 dbSNP
rs1455153209 1498 dbSNP
rs999713892 1501 dbSNP
rs1368057448 1507 dbSNP
rs189317657 1508 dbSNP
rs891581411 1522 dbSNP
rs1424881103 1543 dbSNP
rs1386390240 1545 dbSNP
rs1479130303 1549 dbSNP
rs1253820972 1556 dbSNP
rs916179980 1557 dbSNP
rs748527927 1561 dbSNP
rs1463582873 1563 dbSNP
rs1337279719 1589 dbSNP
rs1269985775 1595 dbSNP
rs1046159341 1598 dbSNP
rs1011649480 1603 dbSNP
rs924600069 1605 dbSNP
rs1276265371 1606 dbSNP
rs1220676774 1609 dbSNP
rs1367908908 1617 dbSNP
rs1384451567 1618 dbSNP
rs1021209424 1619 dbSNP
rs879733747 1623 dbSNP
rs1366733445 1627 dbSNP
rs1323204410 1628 dbSNP
rs996025251 1630 dbSNP
rs1311571775 1636 dbSNP
rs1335936625 1639 dbSNP
rs557095730 1641 dbSNP
rs575307172 1642 dbSNP
rs73872562 1646 dbSNP
rs1270470661 1649 dbSNP
rs1007427333 1651 dbSNP
rs558185658 1656 dbSNP
rs907950143 1660 dbSNP
rs374375729 1661 dbSNP
rs997415880 1669 dbSNP
rs1482889848 1685 dbSNP
rs1235630817 1702 dbSNP
rs1212006019 1703 dbSNP
rs1026407972 1709 dbSNP
rs1484285769 1712 dbSNP
rs1225708687 1718 dbSNP
rs563049504 1718 dbSNP
rs950348722 1723 dbSNP
rs763339589 1730 dbSNP
rs1297699691 1732 dbSNP
rs1227205080 1738 dbSNP
rs766960024 1739 dbSNP
rs773739109 1742 dbSNP
rs916547697 1743 dbSNP
rs573975837 1745 dbSNP
rs948056399 1745 dbSNP
rs1450685007 1759 dbSNP
rs1255777527 1760 dbSNP
rs1005841644 1766 dbSNP
rs148655217 1769 dbSNP
rs1392188240 1773 dbSNP
rs1171266908 1774 dbSNP
rs1423271992 1776 dbSNP
rs928232706 1779 dbSNP
rs1183517492 1781 dbSNP
rs1485908181 1791 dbSNP
rs1250814799 1798 dbSNP
rs1202677618 1799 dbSNP
rs1184227166 1800 dbSNP
rs1251477475 1814 dbSNP
rs1220251339 1815 dbSNP
rs1409539915 1818 dbSNP
rs935493522 1820 dbSNP
rs578087117 1825 dbSNP
rs1456507770 1830 dbSNP
rs543661528 1833 dbSNP
rs1311292327 1839 dbSNP
rs1356598528 1848 dbSNP
rs1052649179 1852 dbSNP
rs1177143721 1855 dbSNP
rs893971479 1858 dbSNP
rs947115654 1860 dbSNP
rs1298942152 1863 dbSNP
rs551745807 1866 dbSNP
rs763401499 1869 dbSNP
rs959103154 1870 dbSNP
rs1042806333 1875 dbSNP
rs141262441 1879 dbSNP
rs1475495607 1881 dbSNP
rs1408118051 1882 dbSNP
rs534987065 1897 dbSNP
rs1023103275 1905 dbSNP
rs1396559933 1909 dbSNP
rs972063320 1911 dbSNP
rs879119587 1912 dbSNP
rs1030186666 1913 dbSNP
rs981676031 1928 dbSNP
rs924852798 1930 dbSNP
rs1213705509 1931 dbSNP
rs1336153721 1937 dbSNP
rs1392811786 1939 dbSNP
rs1268005502 1941 dbSNP
rs1005117419 1955 dbSNP
rs200296689 1969 dbSNP
rs934682383 1973 dbSNP
rs990136065 1976 dbSNP
rs1286063701 1996 dbSNP
rs766773308 2003 dbSNP
rs775105699 2005 dbSNP
rs1386434845 2007 dbSNP
rs914682044 2008 dbSNP
rs1314416415 2009 dbSNP
rs1461984532 2010 dbSNP
rs150784852 2015 dbSNP
rs1023740133 2022 dbSNP
rs1255538604 2029 dbSNP
rs531052499 2039 dbSNP
rs1039292533 2040 dbSNP
rs1207651186 2050 dbSNP
rs1197831586 2051 dbSNP
rs982146757 2060 dbSNP
rs1268976632 2064 dbSNP
rs928196647 2066 dbSNP
rs901644472 2069 dbSNP
rs1207368866 2072 dbSNP
rs1427205284 2074 dbSNP
rs935561230 2077 dbSNP
rs1232934668 2080 dbSNP
rs866200355 2083 dbSNP
rs1431413881 2085 dbSNP
rs1175232245 2089 dbSNP
rs1354676876 2094 dbSNP
rs1463057961 2095 dbSNP
rs568526061 2100 dbSNP
rs1047680595 2101 dbSNP
rs781293940 2117 dbSNP
rs915387963 2121 dbSNP
rs1304081435 2122 dbSNP
rs946887154 2138 dbSNP
rs1385499308 2146 dbSNP
rs1171817663 2147 dbSNP
rs1042773687 2148 dbSNP
rs373139334 2151 dbSNP
rs886352231 2158 dbSNP
rs900283200 2163 dbSNP
rs1370154971 2173 dbSNP
rs1218025891 2178 dbSNP
rs1301185506 2182 dbSNP
rs1448408040 2182 dbSNP
rs1245675773 2184 dbSNP
rs1005874191 2186 dbSNP
rs1051412043 2187 dbSNP
rs930860005 2202 dbSNP
rs1015866373 2208 dbSNP
rs1004764554 2212 dbSNP
rs1235282285 2220 dbSNP
rs1295502430 2234 dbSNP
rs894918961 2235 dbSNP
rs537661263 2237 dbSNP
rs1326980731 2238 dbSNP
rs1482821513 2239 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM545212. RNA binding protein: AGO1. Condition:Control ...

- Hafner M; Landthaler M; Burger L; Khorshid et al., 2010, Cell.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' aguggUAACGAU--UUCACGUUAa 5'
               || | ||    ||||||| 
Target 5' uuuaaAUGGGUACUUUGUGCAAUu 3'
 		1 - 24
Article - Hafner M; Landthaler M; Burger L; Khorshid et al.
- Cell, 2010
RNA transcripts are subject to posttranscriptional gene regulation involving hundreds of RNA-binding proteins (RBPs) and microRNA-containing ribonucleoprotein complexes (miRNPs) expressed in a cell-type dependent fashion. We developed a cell-based crosslinking approach to determine at high resolution and transcriptome-wide the binding sites of cellular RBPs and miRNPs. The crosslinked sites are revealed by thymidine to cytidine transitions in the cDNAs prepared from immunopurified RNPs of 4-thiouridine-treated cells. We determined the binding sites and regulatory consequences for several intensely studied RBPs and miRNPs, including PUM2, QKI, IGF2BP1-3, AGO/EIF2C1-4 and TNRC6A-C. Our study revealed that these factors bind thousands of sites containing defined sequence motifs and have distinct preferences for exonic versus intronic or coding versus untranslated transcript regions. The precise mapping of binding sites across the transcriptome will be critical to the interpretation of the rapidly emerging data on genetic variation between individuals and how these variations contribute to complex genetic diseases.
LinkOut: [PMID: 20371350]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Disease 51809.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM714644. RNA binding protein: AGO2. Condition:completeT1 "PAR-CLIP data was present in GSM714645. RNA binding protein: AGO2. Condition:completeT1 ...

- Kishore S; Jaskiewicz L; Burger L; Hausser et al., 2011, Nature methods.

Article - Kishore S; Jaskiewicz L; Burger L; Hausser et al.
- Nature methods, 2011
Cross-linking and immunoprecipitation (CLIP) is increasingly used to map transcriptome-wide binding sites of RNA-binding proteins. We developed a method for CLIP data analysis, and applied it to compare CLIP with photoactivatable ribonucleoside-enhanced CLIP (PAR-CLIP) and to uncover how differences in cross-linking and ribonuclease digestion affect the identified sites. We found only small differences in accuracies of these methods in identifying binding sites of HuR, which binds low-complexity sequences, and Argonaute 2, which has a complex binding specificity. We found that cross-link-induced mutations led to single-nucleotide resolution for both PAR-CLIP and CLIP. Our results confirm the expectation from original CLIP publications that RNA-binding proteins do not protect their binding sites sufficiently under the denaturing conditions used during the CLIP procedure, and we show that extensive digestion with sequence-specific RNases strongly biases the recovered binding sites. This bias can be substantially reduced by milder nuclease digestion conditions.
LinkOut: [PMID: 21572407]
Experimental Support 3 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions hESCs (WA-09)
Disease 51809.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in SRR359787. RNA binding protein: AGO2. Condition:4-thiouridine ...

- Lipchina I; Elkabetz Y; Hafner M; Sheridan et al., 2011, Genes & development.

Article - Lipchina I; Elkabetz Y; Hafner M; Sheridan et al.
- Genes & development, 2011
MicroRNAs are important regulators in many cellular processes, including stem cell self-renewal. Recent studies demonstrated their function as pluripotency factors with the capacity for somatic cell reprogramming. However, their role in human embryonic stem (ES) cells (hESCs) remains poorly understood, partially due to the lack of genome-wide strategies to identify their targets. Here, we performed comprehensive microRNA profiling in hESCs and in purified neural and mesenchymal derivatives. Using a combination of AGO cross-linking and microRNA perturbation experiments, together with computational prediction, we identified the targets of the miR-302/367 cluster, the most abundant microRNAs in hESCs. Functional studies identified novel roles of miR-302/367 in maintaining pluripotency and regulating hESC differentiation. We show that in addition to its role in TGF-beta signaling, miR-302/367 promotes bone morphogenetic protein (BMP) signaling by targeting BMP inhibitors TOB2, DAZAP2, and SLAIN1. This study broadens our understanding of microRNA function in hESCs and is a valuable resource for future studies in this area.
LinkOut: [PMID: 22012620]
CLIP-seq Support 1 for dataset GSM545212
Method / RBP PAR-CLIP / AGO1
Cell line / Condition HEK293 / Control
Location of target site ENST00000265000.4 | 3UTR | UUUAAAUGGGUACUUUGUGCAAUUCG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 20371350 / GSE21578
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM714644
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / completeT1, repA
Location of target site ENST00000265000.4 | 3UTR | UAAAUUUUAAAUGGGUACUUUGUGCAAUUCG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 21572407 / GSE28865
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM714645
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / completeT1, repB
Location of target site ENST00000265000.4 | 3UTR | UAAAUUUUAAAUGGGUACUUUGUGCAAUUCG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 21572407 / GSE28865
CLIP-seq Viewer Link
CLIP-seq Support 4 for dataset SRR359787
Method / RBP PAR-CLIP / AGO2
Cell line / Condition hESCs (WA-09) / 4-thiouridine, RNase T1
Location of target site ENST00000265000.4 | 3UTR | UAAAUUUUAAAUGGGUACUUUGUGCAAUUCG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 22012620 / SRX103431
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE28544 Breast cancer 0.69 9.5e-5 0.772 5.0e-6 24 Click to see details
GSE28260 Renal cortex and medulla 0.807 4.3e-4 0.782 7.9e-4 13 Click to see details
GSE42095 Differentiated embryonic stem cells 0.601 1.2e-3 0.645 4.5e-4 23 Click to see details
GSE21849 B cell lymphoma 0.349 3.2e-2 0.515 2.1e-3 29 Click to see details
GSE38226 Liver fibrosis 0.27 1.2e-1 -0.047 4.2e-1 21 Click to see details
GSE27834 Pluripotent stem cells -0.289 1.4e-1 -0.100 3.6e-1 16 Click to see details
GSE17306 Multiple myeloma -0.153 1.5e-1 0.294 2.0e-2 49 Click to see details
GSE38974 Chronic obstructive pulmonary disease 0.199 1.7e-1 0.102 3.1e-1 25 Click to see details
GSE14794 Lymphoblastoid cells -0.079 2.3e-1 -0.061 2.8e-1 90 Click to see details
GSE32688 Pancreatic cancer 0.12 2.6e-1 0.190 1.5e-1 32 Click to see details
GSE26953 Aortic valvular endothelial cells 0.075 3.6e-1 0.034 4.4e-1 24 Click to see details
GSE17498 Multiple myeloma 0.041 4.0e-1 0.093 2.8e-1 40 Click to see details
GSE21687 Ependynoma primary tumors -0.021 4.3e-1 -0.026 4.2e-1 64 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis 0.038 4.4e-1 -0.398 4.1e-2 20 Click to see details
GSE15076 Monocyte-derived dendritic cells -0.059 4.6e-1 -0.500 2.0e-1 5 Click to see details
GSE19350 CNS germ cell tumors -0.002 5.0e-1 0.091 3.9e-1 12 Click to see details
GSE19350 CNS germ cell tumors -0.002 5.0e-1 0.091 3.9e-1 12 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
255 hsa-miR-367-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT055315 DUSP5 dual specificity phosphatase 5 2 8
MIRT055791 PLEKHA1 pleckstrin homology domain containing A1 2 12
MIRT057114 DDIT4 DNA damage inducible transcript 4 2 4
MIRT059663 GATAD2B GATA zinc finger domain containing 2B 2 2
MIRT059926 ZDHHC5 zinc finger DHHC-type containing 5 2 2
MIRT061610 BTG2 BTG anti-proliferation factor 2 2 6
MIRT066478 HMGA2 high mobility group AT-hook 2 2 2
MIRT069388 ZFYVE21 zinc finger FYVE-type containing 21 2 2
MIRT069972 GEMIN2 gem nuclear organelle associated protein 2 2 2
MIRT074764 CNEP1R1 CTD nuclear envelope phosphatase 1 regulatory subunit 1 2 2
MIRT076199 GID4 GID complex subunit 4 homolog 2 6
MIRT077512 UBE2Z ubiquitin conjugating enzyme E2 Z 2 4
MIRT077903 TOB1 transducer of ERBB2, 1 2 6
MIRT082250 MED29 mediator complex subunit 29 2 4
MIRT082434 CIC capicua transcriptional repressor 2 6
MIRT082474 PPP1R37 protein phosphatase 1 regulatory subunit 37 2 2
MIRT082778 ZNF264 zinc finger protein 264 2 2
MIRT084533 BCL2L11 BCL2 like 11 2 8
MIRT085309 UBXN4 UBX domain protein 4 2 8
MIRT086365 SSFA2 sperm specific antigen 2 2 8
MIRT087455 NF2 neurofibromin 2 2 2
MIRT088865 FOXN2 forkhead box N2 2 12
MIRT092185 ITPR1 inositol 1,4,5-trisphosphate receptor type 1 2 6
MIRT092326 EDEM1 ER degradation enhancing alpha-mannosidase like protein 1 2 6
MIRT093533 GALNT7 polypeptide N-acetylgalactosaminyltransferase 7 2 6
MIRT096935 PAPD7 poly(A) RNA polymerase D7, non-canonical 2 8
MIRT097026 MAP1B microtubule associated protein 1B 2 4
MIRT099137 MYLIP myosin regulatory light chain interacting protein 2 6
MIRT099905 SOX4 SRY-box 4 2 12
MIRT102289 DNAJB9 DnaJ heat shock protein family (Hsp40) member B9 2 10
MIRT102507 KLHDC10 kelch domain containing 10 2 2
MIRT102891 INSIG1 insulin induced gene 1 2 2
MIRT109188 VMA21 VMA21, vacuolar ATPase assembly factor 2 4
MIRT124567 PRRC2B proline rich coiled-coil 2B 2 2
MIRT135568 SPRYD4 SPRY domain containing 4 2 2
MIRT161135 SLC25A36 solute carrier family 25 member 36 2 6
MIRT163995 KIAA1109 KIAA1109 2 4
MIRT164689 RNF4 ring finger protein 4 2 2
MIRT167705 HIVEP1 human immunodeficiency virus type I enhancer binding protein 1 2 8
MIRT178956 USP28 ubiquitin specific peptidase 28 2 2
MIRT185717 ARNTL2 aryl hydrocarbon receptor nuclear translocator like 2 2 2
MIRT186264 TCEB3 elongin A 2 2
MIRT186537 TWF1 twinfilin actin binding protein 1 2 4
MIRT186628 COX20 COX20, cytochrome c oxidase assembly factor 2 8
MIRT189373 TXLNA taxilin alpha 2 4
MIRT197013 EIF1 eukaryotic translation initiation factor 1 2 10
MIRT206437 YIPF4 Yip1 domain family member 4 2 2
MIRT211228 FGF2 fibroblast growth factor 2 2 10
MIRT214529 C5ORF24 chromosome 5 open reading frame 24 2 2
MIRT216034 IL6ST interleukin 6 signal transducer 2 10
MIRT218084 TULP4 tubby like protein 4 2 2
MIRT242418 CCDC113 coiled-coil domain containing 113 2 2
MIRT243162 SOX11 SRY-box 11 2 2
MIRT250943 CDK5R1 cyclin dependent kinase 5 regulatory subunit 1 2 4
MIRT253350 ZNF417 zinc finger protein 417 2 2
MIRT271968 ARF1 ADP ribosylation factor 1 2 2
MIRT273214 ZNF695 zinc finger protein 695 2 4
MIRT296114 SLC12A5 solute carrier family 12 member 5 2 2
MIRT301711 TEF TEF, PAR bZIP transcription factor 2 2
MIRT316477 ARID1B AT-rich interaction domain 1B 2 6
MIRT322174 CLN8 CLN8, transmembrane ER and ERGIC protein 2 4
MIRT341538 CNIH1 cornichon family AMPA receptor auxiliary protein 1 2 6
MIRT356062 SMARCA5 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 2 2
MIRT443579 PPIC peptidylprolyl isomerase C 2 2
MIRT448825 FKBP1A FK506 binding protein 1A 2 4
MIRT451494 FOPNL FGFR1OP N-terminal like 2 2
MIRT452694 MDM2 MDM2 proto-oncogene 2 2
MIRT453167 CNOT4 CCR4-NOT transcription complex subunit 4 2 6
MIRT454588 SLC33A1 solute carrier family 33 member 1 2 4
MIRT455794 TAF8 TATA-box binding protein associated factor 8 2 4
MIRT456010 CYP2C19 cytochrome P450 family 2 subfamily C member 19 2 2
MIRT456044 KIAA1586 KIAA1586 2 2
MIRT456763 TMEM239 transmembrane protein 239 2 4
MIRT458068 NLRP9 NLR family pyrin domain containing 9 2 2
MIRT459230 MRPS21 mitochondrial ribosomal protein S21 2 2
MIRT459534 MFF mitochondrial fission factor 2 6
MIRT459759 SNRPD1 small nuclear ribonucleoprotein D1 polypeptide 2 2
MIRT460236 TNFRSF13C TNF receptor superfamily member 13C 2 2
MIRT461104 OPA3 OPA3, outer mitochondrial membrane lipid metabolism regulator 2 2
MIRT462924 ZNRF3 zinc and ring finger 3 2 2
MIRT463476 ZC3HAV1L zinc finger CCCH-type containing, antiviral 1 like 2 2
MIRT463516 ZBTB8B zinc finger and BTB domain containing 8B 2 4
MIRT465503 TOR1B torsin family 1 member B 2 2
MIRT469525 RBFOX2 RNA binding protein, fox-1 homolog 2 2 8
MIRT470079 PTGES2 prostaglandin E synthase 2 2 2
MIRT471581 PARD6B par-6 family cell polarity regulator beta 2 2
MIRT473451 MCOLN2 mucolipin 2 2 8
MIRT475882 H3F3C H3 histone family member 3C 2 10
MIRT475915 H3F3B H3 histone family member 3B 2 8
MIRT476195 GOLGA8A golgin A8 family member A 2 10
MIRT476318 GM2A GM2 ganglioside activator 2 2
MIRT476676 FUT11 fucosyltransferase 11 2 10
MIRT478368 DDI2 DNA damage inducible 1 homolog 2 2 2
MIRT479545 CDC5L cell division cycle 5 like 2 2
MIRT481024 BAZ2B bromodomain adjacent to zinc finger domain 2B 2 2
MIRT491009 ATF7IP activating transcription factor 7 interacting protein 2 2
MIRT493168 MKNK2 MAP kinase interacting serine/threonine kinase 2 2 2
MIRT494345 CASKIN1 CASK interacting protein 1 2 2
MIRT499087 ZDHHC21 zinc finger DHHC-type containing 21 2 6
MIRT500029 ABCF2 ATP binding cassette subfamily F member 2 2 8
MIRT501298 RRN3 RRN3 homolog, RNA polymerase I transcription factor 2 4
MIRT503124 BCL11B B-cell CLL/lymphoma 11B 2 8
MIRT503301 GTF2A1 general transcription factor IIA subunit 1 2 6
MIRT504328 ASGR2 asialoglycoprotein receptor 2 2 6
MIRT504471 EID2B EP300 interacting inhibitor of differentiation 2B 2 2
MIRT504655 RPL9 ribosomal protein L9 2 6
MIRT505331 TMF1 TATA element modulatory factor 1 2 8
MIRT505732 SERTAD3 SERTA domain containing 3 2 4
MIRT505827 RSBN1 round spermatid basic protein 1 2 8
MIRT506004 PURG purine rich element binding protein G 2 8
MIRT506308 PCMTD1 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1 2 6
MIRT506806 KLHL15 kelch like family member 15 2 6
MIRT507119 GOLGA8B golgin A8 family member B 2 6
MIRT507353 FAM129A family with sequence similarity 129 member A 2 6
MIRT507591 DDX3X DEAD-box helicase 3, X-linked 2 4
MIRT507674 CPEB4 cytoplasmic polyadenylation element binding protein 4 2 4
MIRT507703 CNOT2 CCR4-NOT transcription complex subunit 2 2 8
MIRT508012 BCAT1 branched chain amino acid transaminase 1 2 4
MIRT510439 ZIC5 Zic family member 5 2 6
MIRT510539 XKR7 XK related 7 2 4
MIRT510600 TPPP tubulin polymerization promoting protein 2 6
MIRT511060 NRAS NRAS proto-oncogene, GTPase 2 4
MIRT511855 GOLGA8J golgin A8 family member J 2 6
MIRT511865 GOLGA8I golgin A8 family member I, pseudogene 1 3
MIRT512570 CTDSPL CTD small phosphatase like 2 2
MIRT512708 ZNF134 zinc finger protein 134 2 6
MIRT513177 MOAP1 modulator of apoptosis 1 2 6
MIRT513783 PAWR pro-apoptotic WT1 regulator 2 6
MIRT515099 IRGQ immunity related GTPase Q 2 2
MIRT515481 INCENP inner centromere protein 2 4
MIRT517416 BMP8A bone morphogenetic protein 8a 2 2
MIRT518754 C1orf35 chromosome 1 open reading frame 35 2 2
MIRT519780 ZNF354B zinc finger protein 354B 2 4
MIRT519865 ZFP62 ZFP62 zinc finger protein 2 6
MIRT520510 TRAM2 translocation associated membrane protein 2 2 6
MIRT521068 SLC25A32 solute carrier family 25 member 32 2 6
MIRT526912 ZNF772 zinc finger protein 772 2 6
MIRT527134 GULP1 GULP, engulfment adaptor PTB domain containing 1 2 2
MIRT527867 SLC39A14 solute carrier family 39 member 14 2 2
MIRT528404 EIF4EBP2 eukaryotic translation initiation factor 4E binding protein 2 2 2
MIRT532956 ZNF24 zinc finger protein 24 2 4
MIRT533021 ZFC3H1 zinc finger C3H1-type containing 2 4
MIRT533191 WASL Wiskott-Aldrich syndrome like 2 6
MIRT534191 SLC7A11 solute carrier family 7 member 11 2 2
MIRT534961 PTAR1 protein prenyltransferase alpha subunit repeat containing 1 2 4
MIRT536396 LCOR ligand dependent nuclear receptor corepressor 2 2
MIRT537046 GRAMD4 GRAM domain containing 4 2 2
MIRT537125 GOLGA3 golgin A3 2 4
MIRT537183 GFPT2 glutamine-fructose-6-phosphate transaminase 2 2 4
MIRT537652 ERGIC2 ERGIC and golgi 2 2 4
MIRT538632 CCSER2 coiled-coil serine rich protein 2 2 4
MIRT539231 ANP32E acidic nuclear phosphoprotein 32 family member E 2 6
MIRT540099 NPY4R neuropeptide Y receptor Y4 2 2
MIRT540998 ZNF460 zinc finger protein 460 2 4
MIRT541468 AURKA aurora kinase A 2 2
MIRT542680 SESN3 sestrin 3 2 2
MIRT542757 PRRG4 proline rich and Gla domain 4 2 2
MIRT542863 NUCKS1 nuclear casein kinase and cyclin dependent kinase substrate 1 2 2
MIRT542925 HOXC8 homeobox C8 2 2
MIRT543747 SZRD1 SUZ RNA binding domain containing 1 2 2
MIRT544404 ZSCAN12 zinc finger and SCAN domain containing 12 2 2
MIRT544583 AP5Z1 adaptor related protein complex 5 zeta 1 subunit 2 4
MIRT544662 MED19 mediator complex subunit 19 2 2
MIRT545251 GTF2E1 general transcription factor IIE subunit 1 2 2
MIRT545261 TRIM36 tripartite motif containing 36 2 4
MIRT545744 UHRF1BP1 UHRF1 binding protein 1 2 2
MIRT545999 WDR81 WD repeat domain 81 2 2
MIRT546038 VPS4B vacuolar protein sorting 4 homolog B 2 2
MIRT547170 PDZD8 PDZ domain containing 8 2 2
MIRT547273 NUFIP2 NUFIP2, FMR1 interacting protein 2 2 2
MIRT547729 KIF5B kinesin family member 5B 2 2
MIRT548127 GATA6 GATA binding protein 6 2 2
MIRT548203 FNIP1 folliculin interacting protein 1 2 2
MIRT548756 CNNM4 cyclin and CBS domain divalent metal cation transport mediator 4 2 2
MIRT549641 ZNF75A zinc finger protein 75a 2 2
MIRT549684 ZNF598 zinc finger protein 598 2 2
MIRT550197 MRO maestro 2 2
MIRT550340 IPP intracisternal A particle-promoted polypeptide 2 2
MIRT550536 MYZAP myocardial zonula adherens protein 2 2
MIRT550975 TOR4A torsin family 4 member A 2 2
MIRT551221 CIDEC cell death inducing DFFA like effector c 2 2
MIRT551355 AGBL5 ATP/GTP binding protein like 5 2 2
MIRT551571 LETM1 leucine zipper and EF-hand containing transmembrane protein 1 2 2
MIRT552277 RAB3D RAB3D, member RAS oncogene family 2 2
MIRT552661 ZADH2 zinc binding alcohol dehydrogenase domain containing 2 2 2
MIRT553081 UCK2 uridine-cytidine kinase 2 2 2
MIRT553753 TBC1D8 TBC1 domain family member 8 2 2
MIRT554030 SPCS3 signal peptidase complex subunit 3 2 2
MIRT554099 SMU1 DNA replication regulator and spliceosomal factor 2 2
MIRT554155 SLX4 SLX4 structure-specific endonuclease subunit 2 2
MIRT554815 REL REL proto-oncogene, NF-kB subunit 2 2
MIRT555522 PMEPA1 prostate transmembrane protein, androgen induced 1 2 2
MIRT555597 PIP5K1C phosphatidylinositol-4-phosphate 5-kinase type 1 gamma 2 2
MIRT555632 PHLPP2 PH domain and leucine rich repeat protein phosphatase 2 2 4
MIRT555679 PGAM4 phosphoglycerate mutase family member 4 2 4
MIRT555827 PAX9 paired box 9 2 2
MIRT555868 PAIP1 poly(A) binding protein interacting protein 1 2 2
MIRT555939 NUP43 nucleoporin 43 2 2
MIRT555994 NFYB nuclear transcription factor Y subunit beta 2 2
MIRT556340 MAP2K4 mitogen-activated protein kinase kinase 4 2 2
MIRT556432 LONRF3 LON peptidase N-terminal domain and ring finger 3 2 2
MIRT556585 LHFPL2 LHFPL tetraspan subfamily member 2 2 4
MIRT556801 KIAA1958 KIAA1958 2 2
MIRT558047 EXOC5 exocyst complex component 5 2 2
MIRT558697 CLTA clathrin light chain A 2 2
MIRT559191 BMPR1A bone morphogenetic protein receptor type 1A 2 4
MIRT559639 AKAP10 A-kinase anchoring protein 10 2 2
MIRT559707 AEN apoptosis enhancing nuclease 2 2
MIRT560673 SRFBP1 serum response factor binding protein 1 2 2
MIRT560990 GPBP1L1 GC-rich promoter binding protein 1 like 1 2 2
MIRT562170 HOXA13 homeobox A13 2 2
MIRT562275 GNAQ G protein subunit alpha q 2 2
MIRT563624 ZNF277 zinc finger protein 277 2 2
MIRT563815 FMN1 formin 1 2 2
MIRT564096 TLR3 toll like receptor 3 2 2
MIRT565320 TMEM41A transmembrane protein 41A 2 2
MIRT565986 RNF44 ring finger protein 44 2 2
MIRT566047 REV3L REV3 like, DNA directed polymerase zeta catalytic subunit 2 2
MIRT568236 C11orf24 chromosome 11 open reading frame 24 2 2
MIRT568310 BAK1 BCL2 antagonist/killer 1 2 2
MIRT572376 ATOX1 antioxidant 1 copper chaperone 2 2
MIRT574822 CPEB3 cytoplasmic polyadenylation element binding protein 3 2 2
MIRT609212 PELP1 proline, glutamate and leucine rich protein 1 2 2
MIRT616217 RBM27 RNA binding motif protein 27 2 2
MIRT629087 FASLG Fas ligand 2 2
MIRT632124 FKBP9 FK506 binding protein 9 2 2
MIRT632576 POLQ DNA polymerase theta 2 2
MIRT634799 ENTHD1 ENTH domain containing 1 2 2
MIRT636553 ESRP1 epithelial splicing regulatory protein 1 2 2
MIRT640977 ORAI2 ORAI calcium release-activated calcium modulator 2 2 2
MIRT653875 SH2B3 SH2B adaptor protein 3 2 2
MIRT655598 OTUD7B OTU deubiquitinase 7B 2 2
MIRT659764 CCDC171 coiled-coil domain containing 171 2 2
MIRT660744 ALG14 ALG14, UDP-N-acetylglucosaminyltransferase subunit 2 2
MIRT681037 AAED1 AhpC/TSA antioxidant enzyme domain containing 1 2 2
MIRT682305 RBM28 RNA binding motif protein 28 2 2
MIRT682573 EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 2 2
MIRT686217 ZNF267 zinc finger protein 267 2 2
MIRT687209 PLXNA3 plexin A3 2 2
MIRT690630 LAX1 lymphocyte transmembrane adaptor 1 2 2
MIRT692419 AGMAT agmatinase 2 2
MIRT694437 MCF2L2 MCF.2 cell line derived transforming sequence-like 2 2 2
MIRT700725 PNO1 partner of NOB1 homolog 2 2
MIRT701549 NARF nuclear prelamin A recognition factor 2 2
MIRT704379 DAND5 DAN domain BMP antagonist family member 5 2 2
MIRT707935 PPP1R3D protein phosphatase 1 regulatory subunit 3D 2 2
MIRT709939 MRPS16 mitochondrial ribosomal protein S16 2 2
MIRT711371 MED7 mediator complex subunit 7 2 2
MIRT712327 PER2 period circadian clock 2 2 2
MIRT714515 SHE Src homology 2 domain containing E 2 2
MIRT715520 G2E3 G2/M-phase specific E3 ubiquitin protein ligase 2 2
MIRT724294 OSMR oncostatin M receptor 2 2
MIRT725358 MUC21 mucin 21, cell surface associated 2 2
MIRT732242 KLF4 Kruppel like factor 4 3 1
MIRT735384 SPAG5 sperm associated antigen 5 3 0
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-367 Medpor NULL NULL Microarray osteoblast-like cells line (MG-63) 18408260 2008 up-regulated
miR-367 Activin A NULL 229455 Quantitative real-time PCR Human embryonic stem (hES) cells 19885849 2010 up-regulated
miR-367 Mistletoe lectin-I NULL NULL Microarray colorectal cancer cells CLY cells 20955366 2011 down-regulated
miR-367 Doxorubicin approved 31703 Quantitative real-time PCR heart 22859947 2012 up-regulated
miR-367 Paclitaxel approved 36314 Microarray Ovarian cancer cell lines 24220856 2014 up-regulated
miR-367 Glucose NULL 5793 Quantitative real-time PCR endothelial cells 24394957 2014 down-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-367 Paclitaxel 36314 NSC125973 approved sensitive cell line (A2780)
hsa-miR-367-3p Doxorubicin 31703 NSC123127 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-367-3p Verapamil 2520 NSC272366 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-367-3p Siop Treatment Protocol sensitive High Nephroblastoma tissue
hsa-miR-367-3p Paclitaxel 36314 NSC125973 approved resistant High Pan-Cancer cell line (NCI-H460, NCI-H522, NCI-H322M, HOP62, A549, EKVX, MALME-3M, NCI-H226, HT-29, HCT-116, SE-620, HCT-15, HCC2998, COLO205, HS-578T, NCI/ADR-RES, OVCAR8, OVCAR4, ACHN, SN-12C, 786-O, CAKI-1, UO-31, TK-10, A498, SK-MEL-28, UACC-257, M14, UACC-62, SK
hsa-miR-367-3p Doxorubicin 31703 NSC123127 approved sensitive High Hepatocellular Carcinoma tissue and cell line (HepG2)
hsa-miR-367-3p Mitoxantrone 4212 NSC279836 approved sensitive High Breast Cancer cell line (MCF-7)
hsa-miR-367-3p Sorafenib 216239 NSC747971 approved sensitive Low Hepatocellular Carcinoma cell line (SKhep1, HA22T)
hsa-miR-367-3p Osimertinib 71496458 NSC779217 approved resistant cell line (HCC827)
hsa-miR-367-3p Vemurafenib 42611257 NSC761431 approved resistant cell line (LM16)
hsa-miR-367-3p Vemurafenib 42611257 NSC761431 approved resistant cell line (LM36)
hsa-miR-367-3p Sunitinib 5329102 NSC750690 approved resistant tissue (CardA)
hsa-miR-367-3p Paclitaxel 36314 NSC125973 approved sensitive cell line (SKOV3)
hsa-miR-367-3p Cisplatin 5460033 NSC119875 approved resistant cell line (IGROV-1)
hsa-miR-367-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)

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