miRTarBase - #MIRT094089


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pre-miRNA Information
pre-miRNA hsa-mir-134   
Genomic Coordinates chr14: 101054687 - 101054759
Description Homo sapiens miR-134 stem-loop
Comment miR-134 was first identified by cloning studies in mouse .
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-134-3p
Sequence 46| CCUGUGGGCCACCUAGUCACCAA |68
Evidence Experimental
Experiments Illumina
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 23 14 + 101054754 29233923 MiREDiBase
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs773121278 7 dbSNP
rs760717795 8 dbSNP
rs1415917765 9 dbSNP
rs1278249300 10 dbSNP
rs765201848 11 dbSNP
rs1212462908 14 dbSNP
rs752580711 18 dbSNP
rs752786233 23 dbSNP
Putative Targets

Gene Information
Gene Symbol PAICS   
Synonyms ADE2, ADE2H1, AIRC, PAIS
Description phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase
Transcript NM_001079524   
Other Transcripts NM_001079525 , NM_006452   
Expression
Putative miRNA Targets on PAICS
3'UTR of PAICS
(miRNA target sites are highlighted)		 
>PAICS|NM_001079524|3'UTR
   1 GAAAGAATGCCATTGAATTTTTTAGGGGAAAAACTACAAATTTCTAATTTAGCTGAAGGAAAATCAAGCAAGATGAAAAG
  81 GTAATTTTAAATTAGAGAACACAAATAAAATGTATTAGTGAATAAATGCTTCTCTAGATCCATATTAATAAACATGAGCA
 161 TCTAACCCCTCCTTTCTTAGGCTAGACACCAAGATATTTCAGCCAGCCTTTATCATTCCTCTTACTTTATCCTTTTTCCT
 241 TAAGTATTGGTGGTCACTACTATTGAGTTTCTTCCTTAACACTGATTAAATGATCTTAACTCCCTCAGCTAAAACTGGCA
 321 TTACTGACTCCCAGCTATATTTCTCCAGACTTGCATTTTTTTTTTTTTTTTTGAGACAGGGTCTCACTGTCGCCCAGGCT
 401 GGAGTGCAGTGGCGTGATCTCAGTTCACTGCTGCTTTCCCTCCTGGGCTCAAGCAGTTCTCCCACCTCAGCCTCTCGACT
 481 AACAGGGACTATAATCTTGCAGCACCATGCCGAGCTAATTTTATTTTTTGTAGAGATGAGCTCTCACTATGTCACCCAGG
 561 TTCGTCTCAAACTCCTGAACCCTAGTAATTCTCCTATCTCAGCCTCCCAAAGTGCTAGGGTTACAGACATGAGCCACTGT
 641 GCCTGTCTAGACTTGTACTTTCAACTGTCCATTTCTCCCTGTCTGTCCCATGGGCACTCATGAAAAAACAGAATGCTCCC
 721 AACTTTATTCATCTTCCAAGCCTGTAGCTCTTGGTATACTCACTGTTGCAAGTCAGAAGCTTGATTTCATCATTGATGTT
 801 TTTCTCACGTTTCACATCTCACTCATCACCAAGTCATGTTGGTGTTAATTTCTGATTAACCCTTGAATTTACCGTCTTCT
 881 CATCCTCTGTACAAAAGCCTCAAGTGAGGGTCAAATTCAACATTATCCTGATCTAGACAGCCCCCATTCTCAATCCACCC
 961 TTTTCCAAGTTGATTGCCCAAGGACTTCTAACAATAAACTCTCTTTTGCACCACAGACTTCTTTGAAAATATACATGCTG
1041 TTGACCCTCTCTGTAGAAAACCGCACACATAAAACTTACCAACAGATTTCATTGGTTCTTGGGTTCTCCCGAAGCCTATC
1121 CATGGTTTATAGATTAAGAATTGATGAGGTAGCTGGGCACAGTGGCTCACACCTACGATCACAGCACTTCGGGAGGCTGA
1201 AGCAAGCAGATCACTTGAGGTCAGGAGTTTGAGACCAGCCTGGCCAACATGGTGAAACCCTGTCTCTACTAAAAATACAA
1281 AAAGTAGCCAGCCGTGATGACAGGCACCTGTAATCCCAGCTACTCGGGAGGCTGAGGCATGAGAATTGCTTGAACCCGGG
1361 AGGCGGAGGTTGCAGTGAGCCTAGATCATGCCACTGCACTCCAACCTGGGCAGCAGAGCAAGACTCTGTCTCAAAAGGGG
1441 AAAAAAAAAATTGCTGATGTGACCCATGAAGGGAACTCATTTTCCTCGTAATTTTGGACTGCCACACATTGGTACCTTTA
1521 GTTCTCTGAAGGCCCACGTTTTTATCATTAAGACCTATTTGTTAGCTAGTAGAGCTTTATGTTCGCTGTCCATGAAACCT
1601 TCTGTAACCACAGTGACTACAAGTAGTTCTTTCTCTATTGAATTATTAGGTCCAGAATAGAAGATGTCATTGTACACTTT
1681 ATTTCCCTCACACTGTGTTATGCTCTGATGTGCTATGCTTAGCTATCTGTCAGAGATTAGTAAATTATAAAACTCATGTG
1761 TACTACTTAAGTTTATATCTTATGCTAGTTTATAAGAACAATTAAAAGGACTTAGAAGATTAACTTTGGTAAAAAAAAAA
1841 A
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' aaCCACUGAUC-----CACCGGGUGUcc 5'
            ||| :||:|     |||||:||||  
Target 5' gaGGTAGCTGGGCACAGTGGCTCACAcc 3'
 1146 - 1173 137.00 -22.30
2 
miRNA  3' aaccacuGAUCCACCGGGUGUCc 5'
                 ||:  || ||||::| 
Target 5' tttctccCTGTCTGTCCCATGGg 3'
 672 - 694 120.00 -13.90
3 
miRNA  3' aaccacugauccaccgGGUGUCc 5'
                          |||||| 
Target 5' taaactctcttttgcaCCACAGa 3'
 995 - 1017 120.00 -9.60
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN2034806 39 COSMIC
COSN30149005 45 COSMIC
COSN20100106 373 COSMIC
COSN9792659 544 COSMIC
COSN6835566 1059 COSMIC
COSN29629193 1451 COSMIC
COSN7495924 1697 COSMIC
COSN5061788 1775 COSMIC
COSN1298642 2329 COSMIC
COSN19210018 2707 COSMIC
COSN9792660 3088 COSMIC
COSN22525111 3419 COSMIC
COSN6835567 3530 COSMIC
COSN19560362 3542 COSMIC
COSN6835568 4278 COSMIC
COSN7495926 4331 COSMIC
COSN5573644 4416 COSMIC
COSN2034807 4647 COSMIC
COSN8615666 4732 COSMIC
COSN2034809 4919 COSMIC
COSN29917342 4993 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1210753047 3 dbSNP
rs753412614 5 dbSNP
rs754611620 6 dbSNP
rs778548327 10 dbSNP
rs1248781862 13 dbSNP
rs1448921357 15 dbSNP
rs747869565 16 dbSNP
rs1305869544 18 dbSNP
rs1387247176 21 dbSNP
rs758241618 27 dbSNP
rs773503084 29 dbSNP
rs968955572 29 dbSNP
rs767501873 33 dbSNP
rs1301757475 38 dbSNP
rs370924640 38 dbSNP
rs1383895565 40 dbSNP
rs746939298 45 dbSNP
rs1363913392 47 dbSNP
rs770809983 48 dbSNP
rs1034502151 59 dbSNP
rs1317646645 62 dbSNP
rs1404732124 65 dbSNP
rs181202030 67 dbSNP
rs1039508718 69 dbSNP
rs544014526 78 dbSNP
rs1370890771 80 dbSNP
rs867957397 81 dbSNP
rs1169095354 84 dbSNP
rs992472249 88 dbSNP
rs1000496571 103 dbSNP
rs1263389546 111 dbSNP
rs916875777 111 dbSNP
rs1196765977 113 dbSNP
rs1490126888 114 dbSNP
rs1269284980 119 dbSNP
rs970961160 125 dbSNP
rs1053880215 129 dbSNP
rs1337348037 130 dbSNP
rs892353964 131 dbSNP
rs1009465714 135 dbSNP
rs1309548992 138 dbSNP
rs1024743473 139 dbSNP
rs1223087326 142 dbSNP
rs563398796 146 dbSNP
rs908073047 156 dbSNP
rs970573205 159 dbSNP
rs1305311659 160 dbSNP
rs1390207906 165 dbSNP
rs1258300392 172 dbSNP
rs868792259 177 dbSNP
rs973539970 178 dbSNP
rs1297159202 180 dbSNP
rs1002904281 190 dbSNP
rs1034401368 212 dbSNP
rs922021958 220 dbSNP
rs1189942908 221 dbSNP
rs974074842 222 dbSNP
rs1429802236 229 dbSNP
rs1421346622 230 dbSNP
rs1477469777 233 dbSNP
rs919950024 237 dbSNP
rs932028302 242 dbSNP
rs951644741 242 dbSNP
rs777907453 245 dbSNP
rs138713000 251 dbSNP
rs1356063857 258 dbSNP
rs1481674754 261 dbSNP
rs542650181 263 dbSNP
rs890454866 266 dbSNP
rs1203324965 273 dbSNP
rs1324501737 286 dbSNP
rs944152805 287 dbSNP
rs945988804 302 dbSNP
rs1335483977 311 dbSNP
rs1301951746 318 dbSNP
rs1308347597 319 dbSNP
rs186366013 322 dbSNP
rs904386391 327 dbSNP
rs1375496752 329 dbSNP
rs1401873900 338 dbSNP
rs1416129401 346 dbSNP
rs920998219 354 dbSNP
rs1340399877 355 dbSNP
rs1444835448 355 dbSNP
rs1214449066 356 dbSNP
rs1441440435 356 dbSNP
rs878904282 356 dbSNP
rs879171433 356 dbSNP
rs1241399519 359 dbSNP
rs1183058636 361 dbSNP
rs1461978826 362 dbSNP
rs1215671700 373 dbSNP
rs1242134992 374 dbSNP
rs1465765991 375 dbSNP
rs1209653961 376 dbSNP
rs1350447262 377 dbSNP
rs936431247 379 dbSNP
rs1381192450 380 dbSNP
rs1312368395 392 dbSNP
rs4132099 393 dbSNP
rs1382816075 398 dbSNP
rs1335812689 399 dbSNP
rs1486795844 402 dbSNP
rs1384031775 403 dbSNP
rs551408848 407 dbSNP
rs1034164171 409 dbSNP
rs1475002369 410 dbSNP
rs774042287 413 dbSNP
rs878943735 414 dbSNP
rs894232020 415 dbSNP
rs1191335125 422 dbSNP
rs1431276325 423 dbSNP
rs1446616755 424 dbSNP
rs1013924708 425 dbSNP
rs1219246891 435 dbSNP
rs1358003820 441 dbSNP
rs1291711560 442 dbSNP
rs1009436153 444 dbSNP
rs1359557845 445 dbSNP
rs1046331207 450 dbSNP
rs1428258208 452 dbSNP
rs1174875760 464 dbSNP
rs906463244 466 dbSNP
rs564804738 473 dbSNP
rs770566775 477 dbSNP
rs1363410530 478 dbSNP
rs1162889194 479 dbSNP
rs1425171012 490 dbSNP
rs1416114990 493 dbSNP
rs1001969999 496 dbSNP
rs1295737911 502 dbSNP
rs1023959613 507 dbSNP
rs189607421 512 dbSNP
rs545858249 513 dbSNP
rs1015576262 516 dbSNP
rs963633755 518 dbSNP
rs1223946072 522 dbSNP
rs973995599 529 dbSNP
rs1291482044 534 dbSNP
rs1212281800 535 dbSNP
rs922053404 538 dbSNP
rs1338110338 554 dbSNP
rs1278444244 559 dbSNP
rs932090673 564 dbSNP
rs987553490 565 dbSNP
rs911920879 576 dbSNP
rs946027288 586 dbSNP
rs1133207 588 dbSNP
rs1351543771 594 dbSNP
rs1041691767 597 dbSNP
rs1327003946 603 dbSNP
rs1409470477 610 dbSNP
rs1420235652 612 dbSNP
rs1218969773 615 dbSNP
rs1173137303 617 dbSNP
rs1304661596 618 dbSNP
rs1479564774 630 dbSNP
rs982790634 636 dbSNP
rs1200590771 637 dbSNP
rs550357995 646 dbSNP
rs1350257108 657 dbSNP
rs904457516 658 dbSNP
rs1238249312 659 dbSNP
rs1258090746 666 dbSNP
rs1200198181 676 dbSNP
rs1320932331 677 dbSNP
rs935894248 678 dbSNP
rs1447710890 679 dbSNP
rs1056043204 693 dbSNP
rs1216378132 698 dbSNP
rs1277710839 699 dbSNP
rs113639407 702 dbSNP
rs1441347801 702 dbSNP
rs17051687 703 dbSNP
rs1405601043 705 dbSNP
rs1177346398 707 dbSNP
rs1406186289 710 dbSNP
rs1416522947 710 dbSNP
rs1177156869 712 dbSNP
rs975576299 715 dbSNP
rs1238299883 718 dbSNP
rs1179967899 728 dbSNP
rs1013997873 731 dbSNP
rs1192722558 737 dbSNP
rs1313772265 745 dbSNP
rs1281825567 747 dbSNP
rs1223184363 748 dbSNP
rs1253408990 752 dbSNP
rs772147772 754 dbSNP
rs1455303573 766 dbSNP
rs1311626432 770 dbSNP
rs1023989164 776 dbSNP
rs989673986 784 dbSNP
rs1303675295 789 dbSNP
rs1467728664 790 dbSNP
rs1343852264 792 dbSNP
rs886803549 792 dbSNP
rs535563210 794 dbSNP
rs1401864605 797 dbSNP
rs1156519782 808 dbSNP
rs1162165009 809 dbSNP
rs114009770 810 dbSNP
rs1016574888 814 dbSNP
rs141632329 816 dbSNP
rs945009066 818 dbSNP
rs1400824667 821 dbSNP
rs1160701029 831 dbSNP
rs1046065997 834 dbSNP
rs963965620 841 dbSNP
rs180678976 843 dbSNP
rs995063554 845 dbSNP
rs1326921600 847 dbSNP
rs1288082658 850 dbSNP
rs1243624700 853 dbSNP
rs558199894 854 dbSNP
rs953509615 862 dbSNP
rs899036244 864 dbSNP
rs1360129415 866 dbSNP
rs987584819 874 dbSNP
rs116289969 875 dbSNP
rs1027451603 895 dbSNP
rs887192469 896 dbSNP
rs1444819132 899 dbSNP
rs1004190114 907 dbSNP
rs1019638103 910 dbSNP
rs965603435 921 dbSNP
rs967466207 937 dbSNP
rs1488511479 940 dbSNP
rs1264997340 943 dbSNP
rs760683331 952 dbSNP
rs1266182755 955 dbSNP
rs1247070941 956 dbSNP
rs373785510 961 dbSNP
rs1305783209 963 dbSNP
rs976094095 972 dbSNP
rs1219438065 978 dbSNP
rs977827588 981 dbSNP
rs1028488839 982 dbSNP
rs925942948 988 dbSNP
rs1392060884 992 dbSNP
rs185492092 993 dbSNP
rs989670593 999 dbSNP
rs913631677 1002 dbSNP
rs945142311 1003 dbSNP
rs1477930747 1004 dbSNP
rs1319793118 1008 dbSNP
rs1055635914 1011 dbSNP
rs1213066232 1016 dbSNP
rs1197010567 1018 dbSNP
rs915767073 1019 dbSNP
rs1253382376 1025 dbSNP
rs1426387091 1047 dbSNP
rs1480102792 1050 dbSNP
rs557581176 1054 dbSNP
rs949873752 1057 dbSNP
rs1045509690 1061 dbSNP
rs1479718376 1063 dbSNP
rs574248239 1064 dbSNP
rs1176364027 1068 dbSNP
rs981730789 1071 dbSNP
rs1320236605 1078 dbSNP
rs763554221 1083 dbSNP
rs1178375642 1086 dbSNP
rs927657447 1092 dbSNP
rs1331971426 1093 dbSNP
rs1304086975 1100 dbSNP
rs1390119256 1103 dbSNP
rs1370599547 1108 dbSNP
rs937942917 1111 dbSNP
rs1038450560 1112 dbSNP
rs111774353 1116 dbSNP
rs930434325 1117 dbSNP
rs1461370680 1120 dbSNP
rs1166357574 1123 dbSNP
rs1397112254 1133 dbSNP
rs1464425850 1135 dbSNP
rs566378493 1143 dbSNP
rs868559714 1148 dbSNP
rs146221824 1161 dbSNP
rs1417218693 1167 dbSNP
rs1237694643 1168 dbSNP
rs572765723 1175 dbSNP
rs544975327 1177 dbSNP
rs564865808 1178 dbSNP
rs137870283 1185 dbSNP
rs1346176581 1188 dbSNP
rs550419427 1189 dbSNP
rs535421184 1191 dbSNP
rs753368686 1192 dbSNP
rs149463549 1196 dbSNP
rs1307970992 1200 dbSNP
rs1446903031 1210 dbSNP
rs967875464 1218 dbSNP
rs1019605609 1226 dbSNP
rs1334321923 1232 dbSNP
rs764903330 1234 dbSNP
rs997100102 1236 dbSNP
rs1028957856 1239 dbSNP
rs1451633119 1240 dbSNP
rs774612367 1246 dbSNP
rs1196477867 1250 dbSNP
rs1159104265 1253 dbSNP
rs1272043973 1255 dbSNP
rs561750408 1260 dbSNP
rs1241298190 1265 dbSNP
rs1187165537 1266 dbSNP
rs1443182595 1268 dbSNP
rs1258781192 1273 dbSNP
rs957376097 1286 dbSNP
rs796847049 1290 dbSNP
rs1350339741 1292 dbSNP
rs1140982 1293 dbSNP
rs1242903694 1294 dbSNP
rs1355260370 1295 dbSNP
rs549222790 1296 dbSNP
rs949945502 1297 dbSNP
rs547524832 1299 dbSNP
rs966415521 1308 dbSNP
rs1133210 1314 dbSNP
rs1474620323 1317 dbSNP
rs11549977 1319 dbSNP
rs182024285 1325 dbSNP
rs908334654 1326 dbSNP
rs1477140160 1327 dbSNP
rs528504116 1342 dbSNP
rs1359613512 1349 dbSNP
rs1167642524 1353 dbSNP
rs1133212 1355 dbSNP
rs781526902 1356 dbSNP
rs185998169 1358 dbSNP
rs572014157 1359 dbSNP
rs898186319 1365 dbSNP
rs537752262 1366 dbSNP
rs1191219161 1369 dbSNP
rs71601626 1371 dbSNP
rs11549968 1375 dbSNP
rs996528956 1378 dbSNP
rs1415434741 1379 dbSNP
rs1133213 1384 dbSNP
rs1488186887 1385 dbSNP
rs1357227942 1395 dbSNP
rs1049401403 1406 dbSNP
rs11549974 1413 dbSNP
rs150071128 1424 dbSNP
rs889374760 1424 dbSNP
rs1216731539 1425 dbSNP
rs778208484 1427 dbSNP
rs537304749 1431 dbSNP
rs1285622000 1437 dbSNP
rs1009120304 1438 dbSNP
rs1224723944 1440 dbSNP
rs1339647757 1441 dbSNP
rs541899967 1441 dbSNP
rs557644403 1442 dbSNP
rs1363622449 1444 dbSNP
rs116694777 1453 dbSNP
rs557146428 1454 dbSNP
rs1392921331 1456 dbSNP
rs999368312 1460 dbSNP
rs11549967 1466 dbSNP
rs1166395136 1468 dbSNP
rs997210050 1472 dbSNP
rs1424842670 1478 dbSNP
rs1210913297 1479 dbSNP
rs1049766153 1485 dbSNP
rs576996798 1488 dbSNP
rs1246638219 1489 dbSNP
rs1011181722 1500 dbSNP
rs1451696508 1509 dbSNP
rs373868004 1513 dbSNP
rs1021076588 1516 dbSNP
rs552827578 1520 dbSNP
rs966886535 1522 dbSNP
rs1316916547 1530 dbSNP
rs1487555591 1532 dbSNP
rs1193177360 1533 dbSNP
rs957656202 1543 dbSNP
rs541199537 1547 dbSNP
rs1343338685 1551 dbSNP
rs572873876 1555 dbSNP
rs1437049648 1558 dbSNP
rs1171224781 1560 dbSNP
rs959171870 1573 dbSNP
rs544717491 1585 dbSNP
rs1401290493 1586 dbSNP
rs1173027304 1588 dbSNP
rs1022879780 1595 dbSNP
rs749494887 1599 dbSNP
rs1424836603 1603 dbSNP
rs1192332178 1604 dbSNP
rs1479271149 1605 dbSNP
rs1248016723 1606 dbSNP
rs971293567 1618 dbSNP
rs1456887604 1627 dbSNP
rs1238411566 1630 dbSNP
rs1427524038 1638 dbSNP
rs983403795 1651 dbSNP
rs907701519 1653 dbSNP
rs768088567 1660 dbSNP
rs981314507 1660 dbSNP
rs1380448665 1666 dbSNP
rs17086785 1668 dbSNP
rs1307251492 1672 dbSNP
rs1446152874 1676 dbSNP
rs939859208 1688 dbSNP
rs974286259 1698 dbSNP
rs1450690739 1700 dbSNP
rs6584 1702 dbSNP
rs1177235313 1703 dbSNP
rs1416707905 1706 dbSNP
rs559785006 1708 dbSNP
rs1406440403 1718 dbSNP
rs1158499463 1732 dbSNP
rs1229284481 1734 dbSNP
rs749344670 1739 dbSNP
rs1301005664 1756 dbSNP
rs1180178775 1759 dbSNP
rs1482054756 1766 dbSNP
rs922654767 1780 dbSNP
rs144815075 1783 dbSNP
rs932781893 1784 dbSNP
rs1050174616 1788 dbSNP
rs1283809172 1798 dbSNP
rs771059075 1800 dbSNP
rs1049431988 1803 dbSNP
rs893847330 1812 dbSNP
rs1248728251 1814 dbSNP
rs1311510922 1826 dbSNP
rs1226883428 1829 dbSNP
rs1378700483 1839 dbSNP
rs1011106105 1849 dbSNP
rs1234575070 1851 dbSNP
rs890788710 1856 dbSNP
rs779138939 1861 dbSNP
rs1420819964 1866 dbSNP
rs1380422793 1868 dbSNP
rs746073523 1875 dbSNP
rs1421750441 1880 dbSNP
rs1205027982 1881 dbSNP
rs1042587006 1894 dbSNP
rs902777287 1899 dbSNP
rs7693436 1910 dbSNP
rs1035162722 1916 dbSNP
rs1288337406 1921 dbSNP
rs1040609881 1922 dbSNP
rs1197134139 1936 dbSNP
rs1313731344 1944 dbSNP
rs1338956993 1946 dbSNP
rs1277936801 1947 dbSNP
rs1401205183 1954 dbSNP
rs1252773486 1959 dbSNP
rs775393243 1960 dbSNP
rs1455943020 1963 dbSNP
rs1348740220 1967 dbSNP
rs529878558 1973 dbSNP
rs148588555 1976 dbSNP
rs951779503 1980 dbSNP
rs1378523392 1981 dbSNP
rs1192664731 1982 dbSNP
rs983124185 1983 dbSNP
rs1033571254 1987 dbSNP
rs1014808548 1993 dbSNP
rs879543103 1993 dbSNP
rs1266076810 2004 dbSNP
rs1159248238 2005 dbSNP
rs76039912 2007 dbSNP
rs1316279181 2013 dbSNP
rs893223164 2014 dbSNP
rs1012918329 2023 dbSNP
rs1022954657 2025 dbSNP
rs975902140 2035 dbSNP
rs1342702822 2037 dbSNP
rs1323567257 2039 dbSNP
rs1386679136 2046 dbSNP
rs144141427 2049 dbSNP
rs1293594915 2050 dbSNP
rs1462753037 2054 dbSNP
rs981354380 2059 dbSNP
rs985596917 2060 dbSNP
rs915321289 2062 dbSNP
rs1050077372 2063 dbSNP
rs1323768222 2064 dbSNP
rs1015526392 2071 dbSNP
rs1305230972 2072 dbSNP
rs1432503550 2074 dbSNP
rs961568790 2087 dbSNP
rs946683128 2089 dbSNP
rs768591381 2096 dbSNP
rs919720870 2100 dbSNP
rs528579353 2101 dbSNP
rs542203326 2108 dbSNP
rs1353390459 2110 dbSNP
rs1313296252 2111 dbSNP
rs890978219 2112 dbSNP
rs551859766 2119 dbSNP
rs943671356 2126 dbSNP
rs571674165 2129 dbSNP
rs1447023580 2136 dbSNP
rs1398426293 2148 dbSNP
rs1170580283 2155 dbSNP
rs1465541438 2158 dbSNP
rs1027372442 2160 dbSNP
rs1378138274 2165 dbSNP
rs530902136 2166 dbSNP
rs1042417157 2174 dbSNP
rs1437925195 2175 dbSNP
rs1195695137 2180 dbSNP
rs1236537158 2185 dbSNP
rs191711845 2186 dbSNP
rs1459251173 2189 dbSNP
rs1459633663 2204 dbSNP
rs1254601229 2211 dbSNP
rs934867582 2219 dbSNP
rs754669044 2225 dbSNP
rs1258312256 2229 dbSNP
rs1238561754 2234 dbSNP
rs893296857 2236 dbSNP
rs1012992109 2248 dbSNP
rs1385985849 2254 dbSNP
rs1162777856 2277 dbSNP
rs571083987 2281 dbSNP
rs183517898 2282 dbSNP
rs907269964 2283 dbSNP
rs1002897321 2284 dbSNP
rs750137400 2291 dbSNP
rs961327126 2293 dbSNP
rs1402579269 2305 dbSNP
rs536475013 2307 dbSNP
rs1417747811 2316 dbSNP
rs1026859639 2318 dbSNP
rs762592915 2323 dbSNP
rs142858085 2327 dbSNP
rs376695230 2327 dbSNP
rs1471164363 2330 dbSNP
rs915307801 2340 dbSNP
rs188110898 2345 dbSNP
rs1424792619 2391 dbSNP
rs566909162 2396 dbSNP
rs538728858 2397 dbSNP
rs866831333 2401 dbSNP
rs1215147252 2406 dbSNP
rs923965191 2408 dbSNP
rs1284771182 2427 dbSNP
rs796724442 2431 dbSNP
rs1352142527 2434 dbSNP
rs965100970 2436 dbSNP
rs1056749088 2438 dbSNP
rs1340883743 2439 dbSNP
rs895394994 2443 dbSNP
rs561888197 2447 dbSNP
rs948206545 2452 dbSNP
rs1339766700 2453 dbSNP
rs1049712151 2455 dbSNP
rs887496147 2469 dbSNP
rs1004659165 2480 dbSNP
rs558201719 2484 dbSNP
rs1293252903 2488 dbSNP
rs1458584882 2509 dbSNP
rs923567097 2512 dbSNP
rs1420546559 2518 dbSNP
rs901544300 2520 dbSNP
rs1336147060 2521 dbSNP
rs1264547985 2523 dbSNP
rs1215887874 2528 dbSNP
rs1448252661 2531 dbSNP
rs1249985855 2532 dbSNP
rs1208916088 2535 dbSNP
rs147298830 2542 dbSNP
rs1480391018 2544 dbSNP
rs1196668537 2546 dbSNP
rs756607260 2547 dbSNP
rs1335074352 2552 dbSNP
rs1274591286 2555 dbSNP
rs1216586630 2558 dbSNP
rs1252738671 2562 dbSNP
rs1278803304 2573 dbSNP
rs1432774570 2583 dbSNP
rs1329467977 2587 dbSNP
rs140952143 2601 dbSNP
rs1387628791 2603 dbSNP
rs1055112782 2607 dbSNP
rs554468296 2608 dbSNP
rs550318750 2609 dbSNP
rs753873154 2612 dbSNP
rs530843784 2614 dbSNP
rs1011381480 2626 dbSNP
rs540093554 2627 dbSNP
rs1037069527 2628 dbSNP
rs1477311267 2629 dbSNP
rs1244531006 2636 dbSNP
rs897145883 2644 dbSNP
rs1197559553 2645 dbSNP
rs1468496275 2649 dbSNP
rs78191651 2650 dbSNP
rs1026890195 2656 dbSNP
rs1298444749 2657 dbSNP
rs532163853 2668 dbSNP
rs978184882 2671 dbSNP
rs144707727 2673 dbSNP
rs1347171803 2674 dbSNP
rs34502204 2683 dbSNP
rs1216318183 2708 dbSNP
rs960658550 2715 dbSNP
rs191205800 2721 dbSNP
rs916815557 2725 dbSNP
rs948316617 2736 dbSNP
rs1329594775 2738 dbSNP
rs530962699 2752 dbSNP
rs746952997 2757 dbSNP
rs1397978579 2759 dbSNP
rs182199977 2766 dbSNP
rs1401539140 2768 dbSNP
rs1331271267 2772 dbSNP
rs1413061378 2784 dbSNP
rs151277622 2786 dbSNP
rs530430357 2790 dbSNP
rs1454361269 2793 dbSNP
rs965163835 2803 dbSNP
rs746987453 2806 dbSNP
rs1396333412 2808 dbSNP
rs1235686192 2810 dbSNP
rs1293877701 2823 dbSNP
rs74702742 2824 dbSNP
rs1233310084 2833 dbSNP
rs567076392 2846 dbSNP
rs1253251448 2849 dbSNP
rs1277856967 2850 dbSNP
rs997170279 2852 dbSNP
rs1350193280 2855 dbSNP
rs1484826352 2860 dbSNP
rs1307146045 2862 dbSNP
rs1239764678 2865 dbSNP
rs1210180031 2866 dbSNP
rs186802055 2879 dbSNP
rs957921513 2882 dbSNP
rs889026998 2885 dbSNP
rs1335497349 2886 dbSNP
rs1258319334 2895 dbSNP
rs1437102145 2898 dbSNP
rs1376809232 2899 dbSNP
rs1156300700 2903 dbSNP
rs1408283159 2905 dbSNP
rs192435651 2905 dbSNP
rs914845867 2907 dbSNP
rs114937196 2910 dbSNP
rs1417095780 2911 dbSNP
rs1236647278 2914 dbSNP
rs1211568117 2915 dbSNP
rs1486601392 2919 dbSNP
rs1044552853 2932 dbSNP
rs1427741178 2946 dbSNP
rs1284051258 2947 dbSNP
rs928799573 2948 dbSNP
rs998651877 2962 dbSNP
rs1031005650 2966 dbSNP
rs1226794830 2968 dbSNP
rs1378964799 2970 dbSNP
rs73157784 2974 dbSNP
rs1311676915 2975 dbSNP
rs1375597323 2976 dbSNP
rs1339097083 2986 dbSNP
rs1037507019 2988 dbSNP
rs1452456982 2989 dbSNP
rs76150008 2994 dbSNP
rs897184397 2999 dbSNP
rs1345223016 3008 dbSNP
rs554538285 3028 dbSNP
rs574312561 3029 dbSNP
rs758673497 3031 dbSNP
rs1412869815 3038 dbSNP
rs1361660656 3043 dbSNP
rs1006777737 3051 dbSNP
rs1298202803 3062 dbSNP
rs1260973730 3067 dbSNP
rs1192804605 3070 dbSNP
rs1345909904 3072 dbSNP
rs1486260357 3076 dbSNP
rs1233925807 3077 dbSNP
rs184802003 3078 dbSNP
rs1019490978 3088 dbSNP
rs900997023 3089 dbSNP
rs200549438 3090 dbSNP
rs999304927 3093 dbSNP
rs553756991 3098 dbSNP
rs1316393890 3099 dbSNP
rs780018949 3108 dbSNP
rs1240238867 3115 dbSNP
rs1383236664 3118 dbSNP
rs776416501 3128 dbSNP
rs1362098546 3136 dbSNP
rs576985602 3161 dbSNP
rs1433933288 3166 dbSNP
rs553897054 3167 dbSNP
rs565407943 3170 dbSNP
rs1462850241 3171 dbSNP
rs1249669530 3174 dbSNP
rs1023226228 3204 dbSNP
rs575805694 3206 dbSNP
rs933095920 3211 dbSNP
rs980320214 3212 dbSNP
rs1488165844 3218 dbSNP
rs1050078068 3227 dbSNP
rs1436088362 3230 dbSNP
rs6842307 3238 dbSNP
rs938837276 3239 dbSNP
rs972896419 3240 dbSNP
rs1454765787 3253 dbSNP
rs145342268 3254 dbSNP
rs1369312955 3258 dbSNP
rs918684265 3262 dbSNP
rs374109898 3265 dbSNP
rs112979543 3268 dbSNP
rs530013779 3276 dbSNP
rs547286265 3278 dbSNP
rs1374739513 3279 dbSNP
rs1173806803 3280 dbSNP
rs1048434215 3284 dbSNP
rs1395733913 3288 dbSNP
rs145047067 3291 dbSNP
rs1316204790 3298 dbSNP
rs1238019338 3308 dbSNP
rs1196748074 3316 dbSNP
rs998622439 3317 dbSNP
rs141103642 3319 dbSNP
rs188864357 3320 dbSNP
rs1346593039 3326 dbSNP
rs1303490603 3327 dbSNP
rs1467009322 3330 dbSNP
rs901032845 3335 dbSNP
rs999785806 3337 dbSNP
rs113636369 3350 dbSNP
rs969762006 3351 dbSNP
rs1174904979 3362 dbSNP
rs1406692770 3363 dbSNP
rs1401779490 3373 dbSNP
rs1301054337 3377 dbSNP
rs1434002277 3378 dbSNP
rs1376201790 3380 dbSNP
rs1175591985 3386 dbSNP
rs1437828930 3387 dbSNP
rs893557364 3391 dbSNP
rs1010605595 3392 dbSNP
rs537556433 3394 dbSNP
rs1023297254 3395 dbSNP
rs1461212284 3398 dbSNP
rs1016501778 3400 dbSNP
rs1396895351 3406 dbSNP
rs962304513 3407 dbSNP
rs969007912 3410 dbSNP
rs1283007960 3411 dbSNP
rs1212420018 3412 dbSNP
rs772680785 3419 dbSNP
rs762613387 3420 dbSNP
rs146719419 3423 dbSNP
rs546780806 3444 dbSNP
rs140349416 3446 dbSNP
rs1332627800 3447 dbSNP
rs1212776903 3454 dbSNP
rs960295067 3455 dbSNP
rs557480571 3463 dbSNP
rs576253058 3469 dbSNP
rs947001442 3469 dbSNP
rs1042721140 3470 dbSNP
rs903078335 3471 dbSNP
rs1455532586 3472 dbSNP
rs554072291 3478 dbSNP
rs775833270 3482 dbSNP
rs931419717 3496 dbSNP
rs934607293 3500 dbSNP
rs1202072249 3510 dbSNP
rs1475706625 3511 dbSNP
rs1260259700 3512 dbSNP
rs1231791035 3516 dbSNP
rs1192080432 3520 dbSNP
rs1056875474 3527 dbSNP
rs1260402930 3529 dbSNP
rs1205415941 3531 dbSNP
rs1352387028 3538 dbSNP
rs984199736 3543 dbSNP
rs1183751415 3546 dbSNP
rs17086786 3552 dbSNP
rs1475177877 3553 dbSNP
rs1325993063 3555 dbSNP
rs78933965 3558 dbSNP
rs1041036486 3559 dbSNP
rs1416497854 3560 dbSNP
rs1388864749 3562 dbSNP
rs922515751 3563 dbSNP
rs935230834 3565 dbSNP
rs1006199638 3566 dbSNP
rs1420431521 3569 dbSNP
rs1016303361 3573 dbSNP
rs1052734545 3575 dbSNP
rs1372067293 3577 dbSNP
rs893639876 3583 dbSNP
rs143483462 3585 dbSNP
rs1044780206 3587 dbSNP
rs962273808 3590 dbSNP
rs1212634645 3594 dbSNP
rs754435655 3604 dbSNP
rs972350424 3606 dbSNP
rs1212808021 3607 dbSNP
rs1411696384 3615 dbSNP
rs1003182105 3617 dbSNP
rs1338677818 3619 dbSNP
rs1270637434 3630 dbSNP
rs1229734929 3638 dbSNP
rs1034651444 3639 dbSNP
rs960576925 3641 dbSNP
rs994422451 3644 dbSNP
rs1311166815 3648 dbSNP
rs1441886661 3651 dbSNP
rs1353413861 3652 dbSNP
rs1232671388 3655 dbSNP
rs1329721211 3664 dbSNP
rs1026269458 3665 dbSNP
rs1293664218 3665 dbSNP
rs1358260713 3668 dbSNP
rs1212404001 3675 dbSNP
rs1170095560 3677 dbSNP
rs1030489130 3680 dbSNP
rs1392685477 3688 dbSNP
rs952836601 3692 dbSNP
rs1271799499 3694 dbSNP
rs1454446597 3697 dbSNP
rs1254422443 3699 dbSNP
rs193028943 3701 dbSNP
rs1273669507 3702 dbSNP
rs1197454443 3707 dbSNP
rs1345882913 3709 dbSNP
rs1302746556 3710 dbSNP
rs1235382092 3723 dbSNP
rs1206601411 3732 dbSNP
rs544738787 3738 dbSNP
rs986317439 3739 dbSNP
rs1307273218 3742 dbSNP
rs1441956402 3744 dbSNP
rs910268410 3745 dbSNP
rs372777142 3761 dbSNP
rs1331505088 3766 dbSNP
rs1413256096 3769 dbSNP
rs6848187 3770 dbSNP
rs964086598 3781 dbSNP
rs1434739572 3783 dbSNP
rs1396530853 3785 dbSNP
rs548707035 3786 dbSNP
rs1469475730 3788 dbSNP
rs1233224308 3794 dbSNP
rs1370544582 3795 dbSNP
rs537368545 3797 dbSNP
rs1167731258 3799 dbSNP
rs1211701978 3800 dbSNP
rs1350077228 3802 dbSNP
rs922622673 3804 dbSNP
rs934576036 3805 dbSNP
rs935287249 3806 dbSNP
rs540873098 3807 dbSNP
rs765455551 3814 dbSNP
rs915105969 3816 dbSNP
rs1313973414 3817 dbSNP
rs1414902470 3819 dbSNP
rs1376711567 3823 dbSNP
rs1414068562 3828 dbSNP
rs1044250372 3832 dbSNP
rs1334791347 3846 dbSNP
rs946566666 3849 dbSNP
rs1044854998 3856 dbSNP
rs904952733 3857 dbSNP
rs1342226051 3872 dbSNP
rs117246694 3878 dbSNP
rs113235277 3882 dbSNP
rs1486715628 3884 dbSNP
rs1056566784 3889 dbSNP
rs1269388253 3892 dbSNP
rs371935771 3894 dbSNP
rs897486850 3895 dbSNP
rs560885689 3898 dbSNP
rs1025880679 3908 dbSNP
rs1231873398 3910 dbSNP
rs1334570793 3928 dbSNP
rs532656008 3931 dbSNP
rs758726834 3936 dbSNP
rs9993507 3944 dbSNP
rs1286605094 3946 dbSNP
rs964160604 3947 dbSNP
rs993502695 3948 dbSNP
rs562748362 3957 dbSNP
rs1459707305 3958 dbSNP
rs1030959726 3963 dbSNP
rs976862295 3963 dbSNP
rs1445797931 3970 dbSNP
rs1165625301 3978 dbSNP
rs558550591 3981 dbSNP
rs922619892 4005 dbSNP
rs956719658 4008 dbSNP
rs150085765 4014 dbSNP
rs527789340 4023 dbSNP
rs1486207768 4025 dbSNP
rs1244089603 4030 dbSNP
rs138415628 4033 dbSNP
rs1468360347 4039 dbSNP
rs6843587 4042 dbSNP
rs1235750605 4048 dbSNP
rs1306271204 4049 dbSNP
rs1295415865 4064 dbSNP
rs9993594 4071 dbSNP
rs547075808 4078 dbSNP
rs1174408718 4079 dbSNP
rs1299415790 4080 dbSNP
rs1438230867 4082 dbSNP
rs978519983 4083 dbSNP
rs1404185425 4091 dbSNP
rs189829311 4092 dbSNP
rs1352710690 4093 dbSNP
rs1169607295 4094 dbSNP
rs1317373345 4094 dbSNP
rs939137545 4095 dbSNP
rs570802116 4105 dbSNP
rs1192055382 4109 dbSNP
rs955666353 4110 dbSNP
rs1253786981 4111 dbSNP
rs1215954635 4114 dbSNP
rs1479832664 4121 dbSNP
rs1251269984 4126 dbSNP
rs908665139 4137 dbSNP
rs992525809 4137 dbSNP
rs181429342 4143 dbSNP
rs928999298 4144 dbSNP
rs917126122 4145 dbSNP
rs1369808084 4154 dbSNP
rs1233280247 4155 dbSNP
rs1303626607 4155 dbSNP
rs1370869018 4155 dbSNP
rs1257258119 4156 dbSNP
rs11359661 4157 dbSNP
rs1248760021 4157 dbSNP
rs1250230735 4157 dbSNP
rs1417745720 4157 dbSNP
rs1462425264 4157 dbSNP
rs1491012705 4157 dbSNP
rs1491546341 4157 dbSNP
rs565748921 4157 dbSNP
rs796532701 4157 dbSNP
rs1349079873 4158 dbSNP
rs1205117261 4160 dbSNP
rs1049180018 4167 dbSNP
rs1481902996 4172 dbSNP
rs1285361824 4173 dbSNP
rs202201773 4175 dbSNP
rs1192183474 4177 dbSNP
rs888710362 4179 dbSNP
rs1044605309 4185 dbSNP
rs556467353 4190 dbSNP
rs909759034 4199 dbSNP
rs1005800636 4207 dbSNP
rs1018495497 4216 dbSNP
rs1391694241 4222 dbSNP
rs1352267934 4224 dbSNP
rs1454877791 4226 dbSNP
rs1310939475 4227 dbSNP
rs899985750 4230 dbSNP
rs6849183 4233 dbSNP
rs1037753332 4236 dbSNP
rs1376108997 4236 dbSNP
rs369720698 4248 dbSNP
rs1363651192 4254 dbSNP
rs1362205049 4255 dbSNP
rs1468527323 4256 dbSNP
rs897912430 4258 dbSNP
rs550190037 4259 dbSNP
rs1256063443 4263 dbSNP
rs1187824209 4265 dbSNP
rs1029759983 4273 dbSNP
rs140881859 4274 dbSNP
rs1157977972 4277 dbSNP
rs956983146 4282 dbSNP
rs1389065389 4288 dbSNP
rs988162598 4289 dbSNP
rs1485087260 4290 dbSNP
rs1458582671 4295 dbSNP
rs373502598 4306 dbSNP
rs1051782931 4313 dbSNP
rs1259726357 4321 dbSNP
rs553242070 4332 dbSNP
rs1302747564 4338 dbSNP
rs879029285 4346 dbSNP
rs1330894481 4350 dbSNP
rs1291404643 4361 dbSNP
rs967971015 4362 dbSNP
rs980652483 4375 dbSNP
rs926481886 4386 dbSNP
rs1333528832 4387 dbSNP
rs890688733 4390 dbSNP
rs1238919548 4393 dbSNP
rs939183741 4398 dbSNP
rs574831101 4399 dbSNP
rs1380532986 4402 dbSNP
rs1384556106 4403 dbSNP
rs1212145144 4413 dbSNP
rs1289627982 4414 dbSNP
rs1018186832 4419 dbSNP
rs1416115589 4423 dbSNP
rs919030266 4425 dbSNP
rs1469070254 4427 dbSNP
rs968891380 4427 dbSNP
rs1475820398 4432 dbSNP
rs199895440 4434 dbSNP
rs140820209 4435 dbSNP
rs75684717 4437 dbSNP
rs1444726959 4457 dbSNP
rs1260643726 4467 dbSNP
rs540660477 4471 dbSNP
rs955804093 4472 dbSNP
rs1412560776 4473 dbSNP
rs1271023671 4476 dbSNP
rs1213065895 4477 dbSNP
rs1335395252 4480 dbSNP
rs929007158 4489 dbSNP
rs748159694 4495 dbSNP
rs1473541147 4497 dbSNP
rs1048795373 4498 dbSNP
rs1325902071 4503 dbSNP
rs376138080 4504 dbSNP
rs1162448138 4506 dbSNP
rs553757408 4513 dbSNP
rs1437532274 4520 dbSNP
rs1416981349 4526 dbSNP
rs992891750 4530 dbSNP
rs1458075357 4531 dbSNP
rs1294966458 4533 dbSNP
rs941620123 4535 dbSNP
rs77293506 4547 dbSNP
rs1393547574 4548 dbSNP
rs1390260820 4550 dbSNP
rs546112660 4555 dbSNP
rs1308121002 4570 dbSNP
rs1371971948 4579 dbSNP
rs1352792342 4591 dbSNP
rs900055073 4593 dbSNP
rs998384118 4602 dbSNP
rs1293051104 4609 dbSNP
rs562810578 4618 dbSNP
rs531823817 4619 dbSNP
rs542038701 4620 dbSNP
rs370609295 4638 dbSNP
rs1451929753 4639 dbSNP
rs1249799833 4645 dbSNP
rs1193982973 4646 dbSNP
rs1010057750 4665 dbSNP
rs561868091 4666 dbSNP
rs909810101 4667 dbSNP
rs541918248 4668 dbSNP
rs968003207 4676 dbSNP
rs1483993177 4677 dbSNP
rs972576813 4682 dbSNP
rs1185775279 4685 dbSNP
rs1256503421 4689 dbSNP
rs1424133682 4693 dbSNP
rs1395227198 4697 dbSNP
rs1166678487 4702 dbSNP
rs1370923084 4705 dbSNP
rs919311092 4717 dbSNP
rs1392901739 4734 dbSNP
rs772736030 4735 dbSNP
rs1192584923 4740 dbSNP
rs555749141 4746 dbSNP
rs929434693 4747 dbSNP
rs1168665475 4752 dbSNP
rs1371929111 4753 dbSNP
rs527386381 4756 dbSNP
rs375431504 4760 dbSNP
rs1248228461 4764 dbSNP
rs1033568376 4767 dbSNP
rs769340939 4768 dbSNP
rs1437172841 4770 dbSNP
rs1252381302 4773 dbSNP
rs1207413434 4779 dbSNP
rs1380573906 4780 dbSNP
rs1345769129 4783 dbSNP
rs1398107895 4784 dbSNP
rs1279928169 4791 dbSNP
rs890500978 4801 dbSNP
rs1347645577 4802 dbSNP
rs1293896823 4803 dbSNP
rs1441850447 4803 dbSNP
rs547430476 4804 dbSNP
rs1310337700 4815 dbSNP
rs960883195 4818 dbSNP
rs1411168264 4823 dbSNP
rs570483274 4830 dbSNP
rs568809260 4833 dbSNP
rs56024551 4838 dbSNP
rs1210295728 4841 dbSNP
rs950537726 4849 dbSNP
rs1156611907 4850 dbSNP
rs1483542837 4857 dbSNP
rs1000293209 4862 dbSNP
rs10700835 4863 dbSNP
rs397794499 4863 dbSNP
rs35122659 4864 dbSNP
rs397756827 4866 dbSNP
rs1256876862 4867 dbSNP
rs200769670 4868 dbSNP
rs1211165149 4876 dbSNP
rs1444347012 4883 dbSNP
rs1282351869 4884 dbSNP
rs1223600518 4895 dbSNP
rs1259477549 4908 dbSNP
rs1031830490 4915 dbSNP
rs550132491 4915 dbSNP
rs1231988252 4921 dbSNP
rs1430111651 4922 dbSNP
rs984523111 4924 dbSNP
rs1353096574 4927 dbSNP
rs1301759960 4931 dbSNP
rs1448055434 4931 dbSNP
rs1360565303 4933 dbSNP
rs1448486317 4939 dbSNP
rs1315744910 4950 dbSNP
rs1188864406 4962 dbSNP
rs908906906 4970 dbSNP
rs765205697 4981 dbSNP
rs1412405553 4985 dbSNP
rs143232864 4989 dbSNP
rs1172505384 4994 dbSNP
rs1038698547 4995 dbSNP
rs1416986272 5016 dbSNP
rs969718693 5021 dbSNP
rs774107319 5023 dbSNP
rs373282635 5028 dbSNP
rs921531212 5030 dbSNP
rs1240609944 5034 dbSNP
rs1468033737 5035 dbSNP
rs1215303968 5036 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM545216. RNA binding protein: AGO2. Condition:miR-124 transfection ...

- Hafner M; Landthaler M; Burger L; Khorshid et al., 2010, Cell.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' aaccacugauccaccgGGUGUcc 5'
                          |||||  
Target 5' uaaacucucuuuugcaCCACA-- 3'
 		12 - 32
Article - Hafner M; Landthaler M; Burger L; Khorshid et al.
- Cell, 2010
RNA transcripts are subject to posttranscriptional gene regulation involving hundreds of RNA-binding proteins (RBPs) and microRNA-containing ribonucleoprotein complexes (miRNPs) expressed in a cell-type dependent fashion. We developed a cell-based crosslinking approach to determine at high resolution and transcriptome-wide the binding sites of cellular RBPs and miRNPs. The crosslinked sites are revealed by thymidine to cytidine transitions in the cDNAs prepared from immunopurified RNPs of 4-thiouridine-treated cells. We determined the binding sites and regulatory consequences for several intensely studied RBPs and miRNPs, including PUM2, QKI, IGF2BP1-3, AGO/EIF2C1-4 and TNRC6A-C. Our study revealed that these factors bind thousands of sites containing defined sequence motifs and have distinct preferences for exonic versus intronic or coding versus untranslated transcript regions. The precise mapping of binding sites across the transcriptome will be critical to the interpretation of the rapidly emerging data on genetic variation between individuals and how these variations contribute to complex genetic diseases.
LinkOut: [PMID: 20371350]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Disease 10606.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM714644. RNA binding protein: AGO2. Condition:completeT1 "PAR-CLIP data was present in GSM714645. RNA binding protein: AGO2. Condition:completeT1 ...

- Kishore S; Jaskiewicz L; Burger L; Hausser et al., 2011, Nature methods.

Article - Kishore S; Jaskiewicz L; Burger L; Hausser et al.
- Nature methods, 2011
Cross-linking and immunoprecipitation (CLIP) is increasingly used to map transcriptome-wide binding sites of RNA-binding proteins. We developed a method for CLIP data analysis, and applied it to compare CLIP with photoactivatable ribonucleoside-enhanced CLIP (PAR-CLIP) and to uncover how differences in cross-linking and ribonuclease digestion affect the identified sites. We found only small differences in accuracies of these methods in identifying binding sites of HuR, which binds low-complexity sequences, and Argonaute 2, which has a complex binding specificity. We found that cross-link-induced mutations led to single-nucleotide resolution for both PAR-CLIP and CLIP. Our results confirm the expectation from original CLIP publications that RNA-binding proteins do not protect their binding sites sufficiently under the denaturing conditions used during the CLIP procedure, and we show that extensive digestion with sequence-specific RNases strongly biases the recovered binding sites. This bias can be substantially reduced by milder nuclease digestion conditions.
LinkOut: [PMID: 21572407]
Experimental Support 3 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HCT116
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in ERX177599. RNA binding protein: AGO2. Condition:p53_D_AGO_CLIP_2_1 PAR-CLIP data was present in ERX177623. RNA binding protein: AGO2. Condition:p53_D_AGO_CLIP_4_1 PAR-CLIP data was present in ERX177611. RNA binding protein: AGO2. Condition:p53_D_AGO_CLIP_3_1 ...

- Krell J; Stebbing J; Carissimi C; Dabrowska et al., 2016, Genome research.

Article - Krell J; Stebbing J; Carissimi C; Dabrowska et al.
- Genome research, 2016
DNA damage activates TP53-regulated surveillance mechanisms that are crucial in suppressing tumorigenesis. TP53 orchestrates these responses directly by transcriptionally modulating genes, including microRNAs (miRNAs), and by regulating miRNA biogenesis through interacting with the DROSHA complex. However, whether the association between miRNAs and AGO2 is regulated following DNA damage is not yet known. Here, we show that, following DNA damage, TP53 interacts with AGO2 to induce or reduce AGO2's association of a subset of miRNAs, including multiple let-7 family members. Furthermore, we show that specific mutations in TP53 decrease rather than increase the association of let-7 family miRNAs, reducing their activity without preventing TP53 from interacting with AGO2. This is consistent with the oncogenic properties of these mutants. Using AGO2 RIP-seq and PAR-CLIP-seq, we show that the DNA damage-induced increase in binding of let-7 family members to the RISC complex is functional. We unambiguously determine the global miRNA-mRNA interaction networks involved in the DNA damage response, validating them through the identification of miRNA-target chimeras formed by endogenous ligation reactions. We find that the target complementary region of the let-7 seed tends to have highly fixed positions and more variable ones. Additionally, we observe that miRNAs, whose cellular abundance or differential association with AGO2 is regulated by TP53, are involved in an intricate network of regulatory feedback and feedforward circuits. TP53-mediated regulation of AGO2-miRNA interaction represents a new mechanism of miRNA regulation in carcinogenesis.
LinkOut: [PMID: 26701625]
Experimental Support 4 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions Prostate Tissue
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in SRX1760638. RNA binding protein: AGO2. Condition:AGO-CLIP-PC3-miR148 ...

- Hamilton MP; Rajapakshe KI; Bader DA; Cerne et al., 2016, Neoplasia (New York, N.Y.).

Article - Hamilton MP; Rajapakshe KI; Bader DA; Cerne et al.
- Neoplasia (New York, N.Y.), 2016
MicroRNA (miRNA) deregulation in prostate cancer (PCa) contributes to PCa initiation and metastatic progression. To comprehensively define the cancer-associated changes in miRNA targeting and function in commonly studied models of PCa, we performed photoactivatable ribonucleoside-enhanced cross-linking immunoprecipitation of the Argonaute protein in a panel of PCa cell lines modeling different stages of PCa progression. Using this comprehensive catalogue of miRNA targets, we analyzed miRNA targeting on known drivers of PCa and examined tissue-specific and stage-specific pathway targeting by miRNAs. We found that androgen receptor is the most frequently targeted PCa oncogene and that miR-148a targets the largest number of known PCa drivers. Globally, tissue-specific and stage-specific changes in miRNA targeting are driven by homeostatic response to active oncogenic pathways. Our findings indicate that, even in advanced PCa, the miRNA pool adapts to regulate continuing alterations in the cancer genome to balance oncogenic molecular changes. These findings are important because they are the first to globally characterize miRNA changes in PCa and demonstrate how the miRNA target spectrum responds to staged tumorigenesis.
LinkOut: [PMID: 27292025]
CLIP-seq Support 1 for dataset GSM545216
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / miR-124 transfection
Location of target site ENST00000264221.2 | 3UTR | ACUUCUAACAAUAAACUCUCUUUUGCACCACA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 20371350 / GSE21578
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM714644
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / completeT1, repA
Location of target site ENST00000264221.2 | 3UTR | ACUUCUAACAAUAAACUCUCUUUUGCACCACAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 21572407 / GSE28865
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM714645
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / completeT1, repB
Location of target site ENST00000264221.2 | 3UTR | ACUUCUAACAAUAAACUCUCUUUUGCACCACAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 21572407 / GSE28865
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
64 hsa-miR-134-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT082376 HNRNPUL1 heterogeneous nuclear ribonucleoprotein U like 1 2 6
MIRT091883 ACVR2B activin A receptor type 2B 2 4
MIRT094089 PAICS phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase 2 4
MIRT316375 PPP1R14C protein phosphatase 1 regulatory inhibitor subunit 14C 2 2
MIRT368317 E2F2 E2F transcription factor 2 2 2
MIRT446160 RPL12 ribosomal protein L12 2 2
MIRT458223 SHMT2 serine hydroxymethyltransferase 2 2 2
MIRT483575 SYT2 synaptotagmin 2 2 2
MIRT486251 FASTK Fas activated serine/threonine kinase 2 2
MIRT487556 TM6SF2 transmembrane 6 superfamily member 2 2 4
MIRT488952 CYP2W1 cytochrome P450 family 2 subfamily W member 1 2 2
MIRT489232 ASCL2 achaete-scute family bHLH transcription factor 2 2 4
MIRT491923 WNK2 WNK lysine deficient protein kinase 2 2 2
MIRT504191 FAM127B retrotransposon Gag like 8A 2 2
MIRT517340 ZNF529 zinc finger protein 529 2 4
MIRT528964 FAM19A3 family with sequence similarity 19 member A3, C-C motif chemokine like 2 2
MIRT530497 FADS6 fatty acid desaturase 6 2 2
MIRT539575 UPP2 uridine phosphorylase 2 2 2
MIRT549348 ARC activity regulated cytoskeleton associated protein 2 2
MIRT554316 SHMT1 serine hydroxymethyltransferase 1 2 2
MIRT555311 PPP2R5C protein phosphatase 2 regulatory subunit B'gamma 2 2
MIRT558029 EXT1 exostosin glycosyltransferase 1 2 2
MIRT564075 KIAA1191 KIAA1191 2 2
MIRT569986 TMEM184A transmembrane protein 184A 2 2
MIRT570669 INSIG1 insulin induced gene 1 2 2
MIRT571911 LSM14A LSM14A, mRNA processing body assembly factor 2 4
MIRT574042 PEX26 peroxisomal biogenesis factor 26 2 2
MIRT574076 RNF152 ring finger protein 152 2 2
MIRT575774 Tnfrsf10b tumor necrosis factor receptor superfamily, member 10b 2 2
MIRT576510 Slc35e2 solute carrier family 35, member E2 2 2
MIRT609004 PYGO1 pygopus family PHD finger 1 2 2
MIRT619992 NPAP1 nuclear pore associated protein 1 2 2
MIRT630308 PDP2 pyruvate dehyrogenase phosphatase catalytic subunit 2 2 2
MIRT636261 RRAGC Ras related GTP binding C 2 2
MIRT638834 CRTAP cartilage associated protein 2 2
MIRT639813 TMED8 transmembrane p24 trafficking protein family member 8 2 2
MIRT641938 SCOC short coiled-coil protein 2 2
MIRT644770 TXNRD3NB thioredoxin reductase 3 neighbor 2 2
MIRT650082 MTL5 testis expressed metallothionein like protein 2 2
MIRT651539 WNK1 WNK lysine deficient protein kinase 1 2 2
MIRT653695 SLC25A33 solute carrier family 25 member 33 2 2
MIRT654579 PXMP4 peroxisomal membrane protein 4 2 2
MIRT655804 NOVA2 NOVA alternative splicing regulator 2 2 2
MIRT662741 LRRC3C leucine rich repeat containing 3C 2 2
MIRT667588 LONRF2 LON peptidase N-terminal domain and ring finger 2 2 2
MIRT667730 KIAA1456 KIAA1456 2 2
MIRT667909 ING1 inhibitor of growth family member 1 2 2
MIRT675875 ATP1B4 ATPase Na+/K+ transporting family member beta 4 2 2
MIRT684043 FOLR1 folate receptor 1 2 2
MIRT686239 ZMIZ1 zinc finger MIZ-type containing 1 2 2
MIRT710043 POLL DNA polymerase lambda 2 2
MIRT711988 EXTL3 exostosin like glycosyltransferase 3 2 2
MIRT714061 VHLL VHL like 2 2
MIRT715879 ACIN1 apoptotic chromatin condensation inducer 1 2 2
MIRT716779 C1orf229 chromosome 1 open reading frame 229 2 2
MIRT717104 PXDC1 PX domain containing 1 2 2
MIRT723567 ZBTB34 zinc finger and BTB domain containing 34 2 2
MIRT725668 ABI2 abl interactor 2 2 2
MIRT735690 SYT11 synaptotagmin 11 1 0
MIRT736843 CCND1 cyclin D1 2 0
MIRT736981 MLH1 mutL homolog 1 1 0
MIRT737413 FOXM1 forkhead box M1 3 0
MIRT756143 GPR137 G protein-coupled receptor 137 3 1
MIRT756411 SOX9 SRY-box 9 3 1
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-134 Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) NULL 8490 Microarray mouse brain 19270793 2009 down-regulated
miR-134 Reversine NULL 210332 Microarray C2C12 myoblast cells 24513286 2014 up-regulated
miR-134 Gefitinib approved 123631 Quantitative real-time PCR lung adenocarcinoma cells 24258346 2014 up-regulated
miR-134 Ascorbate approved 54670067 Microarray Metastatic melanoma cell lines 25202679 2014 up-regualted
miR-134 5-aza-2'-deoxycytidine (5-Aza-CdR) + 4-phenylbutyric acid (PBA) NULL NULL Microarray T24 human bladder cancer cells 16766263 2006 up-regulated
miR-134 Vorinostat (SAHA) approved 5311 Microarray A549 human non-small cell lung cancer cells 19513533 2009 up-regulated
miR-134 Testosterone approved 6013 Microarray prostate cancer 21592394 2011 up-regulated
miR-134 Testosterone + 1,25-Dihydroxyvitamin D3 approved NULL Microarray prostate cancer 21592394 2011 up-regulated
miR-134 1,2,6-Tri-O-galloyl-beta-D-glucopyranose NULL NULL Microarray HepG2 hepatocarcinoma cells. 22506400 2011 down-regulated
miR-134 1alpha,25-Dihydroxyvitamin D3 approved 5280453 Microarray prostate cancer 21592394 2011 up-regulated
miR-134 Goserelin approved 47725 Microarray prostate 22674191 2012 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-134 Ceritinib 57379345 NSC776422 approved resistant High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-mir-134 Cisplatin 5460033 NSC119875 approved sensitive cell line (BxPC3)
hsa-mir-134 Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)
hsa-miR-134-3p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-134-3p Cisplatin 5460033 NSC119875 approved resistant cell line (A549)
hsa-miR-134-3p Tamoxifen 2733525 NSC180973 approved sensitive cell line (LCC2)
hsa-miR-134-3p Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)

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